Introduction: Premature Ovarian Failure (POF) is a disease that occurs before the age of 40 due to dysfunction of the ovaries. In these women، the production and secretion of estrogen hormone is not done properly. Such a situation causes irregular or interrupted periods، disturbances in the ovulation process and occurrence of menopausal symptoms. Premature ovarian failure makes it difficult for women to get pregnant، so more research in this field is necessary.
Conclusion: The results showed that one of the recommended ways to repair and regenerate the failing ovarian tissue was the use of platelet-rich plasma (PRP). The positive effects of PRP were dependent on the high concentration of growth factors in the alpha granules of platelets. The results of this review article showed that the use of platelet-rich plasma in restoring ovarian function could be considered as a treatment method in these patients.
{"title":"Platelet Therapy and Ovarian Rejuvenation in Women with Premature Ovarian Failure","authors":"Marzieh Lotfi, Leila Azod, Malihe Lotfi, Fatemeh Tohidi, Seyed Hossein Shahcheraghi","doi":"10.18502/ssu.v31i7.13691","DOIUrl":"https://doi.org/10.18502/ssu.v31i7.13691","url":null,"abstract":"Introduction: Premature Ovarian Failure (POF) is a disease that occurs before the age of 40 due to dysfunction of the ovaries. In these women، the production and secretion of estrogen hormone is not done properly. Such a situation causes irregular or interrupted periods، disturbances in the ovulation process and occurrence of menopausal symptoms. Premature ovarian failure makes it difficult for women to get pregnant، so more research in this field is necessary.
 Conclusion: The results showed that one of the recommended ways to repair and regenerate the failing ovarian tissue was the use of platelet-rich plasma (PRP). The positive effects of PRP were dependent on the high concentration of growth factors in the alpha granules of platelets. The results of this review article showed that the use of platelet-rich plasma in restoring ovarian function could be considered as a treatment method in these patients.
","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-09-26DOI: 10.18502/ssu.v31i7.13698
Masoumeh Mehrabi, Yaser Kazemzadeh, Ali Gorzi, Seyed Ali Hosseini, Saeid Sedaghati
Introduction: Abuse of anabolic steroids can lead to kidney tissue damage.The aim of this study was to investigate the effect of eight weeks of resistance training on inflammatory markers and antioxidant indices of kidney tissue of male rats following testosterone enanthate abuse.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups: 1) Control, 2) Training and 3) Training + Testosterone. Rats in groups 2 and 3 performed resistance training five sessions a week for eight weeks. Moreover, group 3 received 20 mg/kg of testosterone enanthate intramuscularly three days a week. The activity levels of Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) were measured by spectrophotometric method and the gene expression of Interleukin-6 (IL-6) and Tumor necrosis factor alpha (TNF-α) were measured by Real Time PCR method. The data were analyzed using SPSS version 16 software. To analyze the findings, To analyze the findings, one-way analysis of variance was used (P≥0.05).
Results: Resistance training caused a significant decrease in GPx activity (P=0.001) compared to the control group. IL-6 gene expression in the training + testosterone group was significantly more than the training group (P=0.04) and the control group (P=0.001). Training + testosterone caused a significant increase in TNF-α gene expression compared to the training group (P=0.02) and the control group (P=0.008). Furthermore, the level of GPx activity in the training + testosterone group was significantly lower than the control group (P=0.001), but no significant difference was observed in the training + testosterone groups and the training group (P=0.93).
Conclusion: It seems that testosterone abuse along with intense resistance training is associated with a decrease in the function of the antioxidant system and increase in inflammatory markers in the kidney tissue.
简介:滥用合成代谢类固醇可导致肾脏组织损伤。本研究旨在探讨8周抗阻训练对滥用睾酮酸后雄性大鼠肾脏组织炎症标志物和抗氧化指标的影响。方法:将24只雄性Wistar大鼠随机分为3组:1)对照组，2)训练组，3)训练+睾酮组。第2组和第3组的大鼠每周进行5次阻力训练，持续8周。第3组每周3天肌肉注射增强睾酮20 mg/kg。分光光度法检测小鼠血清超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GPx)活性水平，Real Time PCR法检测白细胞介素-6 (IL-6)和肿瘤坏死因子α (TNF-α)基因表达水平。采用SPSS 16版软件对数据进行分析。分析结果，采用单因素方差分析(P≥0.05)。
结果:与对照组相比，阻力训练导致GPx活性显著降低(P=0.001)。IL-6基因在训练+睾酮组的表达量显著高于训练组(P=0.04)和对照组(P=0.001)。与训练组(P=0.02)和对照组(P=0.008)相比，训练+睾酮组TNF-α基因表达显著升高。此外，训练+睾酮组GPx活性水平显著低于对照组(P=0.001)，但训练+睾酮组与训练组间差异无统计学意义(P=0.93)。
结论:睾酮滥用与高强度抗阻训练似乎与肾组织抗氧化系统功能下降和炎症标志物增加有关。
{"title":"Effect of Eight Weeks of Resistance Training on Inflammatory Markers and Antioxidant Indices of Kidney Tissue Following Testosterone Enanthate Abuse in Male Rats","authors":"Masoumeh Mehrabi, Yaser Kazemzadeh, Ali Gorzi, Seyed Ali Hosseini, Saeid Sedaghati","doi":"10.18502/ssu.v31i7.13698","DOIUrl":"https://doi.org/10.18502/ssu.v31i7.13698","url":null,"abstract":"Introduction: Abuse of anabolic steroids can lead to kidney tissue damage.The aim of this study was to investigate the effect of eight weeks of resistance training on inflammatory markers and antioxidant indices of kidney tissue of male rats following testosterone enanthate abuse.
 Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups: 1) Control, 2) Training and 3) Training + Testosterone. Rats in groups 2 and 3 performed resistance training five sessions a week for eight weeks. Moreover, group 3 received 20 mg/kg of testosterone enanthate intramuscularly three days a week. The activity levels of Superoxide dismutase (SOD) and Glutathione peroxidase (GPx) were measured by spectrophotometric method and the gene expression of Interleukin-6 (IL-6) and Tumor necrosis factor alpha (TNF-α) were measured by Real Time PCR method. The data were analyzed using SPSS version 16 software. To analyze the findings, To analyze the findings, one-way analysis of variance was used (P≥0.05).
 Results: Resistance training caused a significant decrease in GPx activity (P=0.001) compared to the control group. IL-6 gene expression in the training + testosterone group was significantly more than the training group (P=0.04) and the control group (P=0.001). Training + testosterone caused a significant increase in TNF-α gene expression compared to the training group (P=0.02) and the control group (P=0.008). Furthermore, the level of GPx activity in the training + testosterone group was significantly lower than the control group (P=0.001), but no significant difference was observed in the training + testosterone groups and the training group (P=0.93).
 Conclusion: It seems that testosterone abuse along with intense resistance training is associated with a decrease in the function of the antioxidant system and increase in inflammatory markers in the kidney tissue.","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134960129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Non-Suicidal Self-Injury (NSSI) has high prevalence among the patients with psychiatric disorders. Self-Injury plays an important role in the treatment, prognosis and risk of suicide, which highlights the need for an appropriate tool to assess the nature and psychological functions of NSSI. Therefore, the aim of this study was to determine the psychometric properties of the Persian version of the Ottawa Self-Injury inventory (OSI) in hospitalized patients.
Methods: The present study was a psychometric study based on analytical method. The research has been performed on 310 patients with non-suicidal self-injury who have been referred to Nekoei-Hedayati Hospital in Qom City. Sample group completed Persian version of the Ottawa Self-Injury inventory. Data were analyzed using SPSS-16 and Cronbach’s alpha coefficient, Content Validity Index (CVI) and Content Validity Ratio (CVR).
Results: The results showed that content validity index in this study was more than 0.75 and content validity ratio for validity of questions was more than 0.79. The impact score of all items (Except for the tenth question) was higher than 1.5 that confirmed the face validity of inventory. The total Cronbach's alpha coefficient was calculated 0.71. Another result of this study was that 52% of patients reported at least one addictive characteristic.
Conclusion: The finding showed that Persian version of Ottawa Self-Injury inventory has appropriate validity (face /content) and reliability in the inpatient population
{"title":"Psychometric Properties of Persian Version of the Ottawa Self-Injury Inventory in Hospitalized Patients","authors":"Akbari Valiollah, Mostafa Vahedian, Parvin Rahmatinejad","doi":"10.18502/ssu.v31i6.13477","DOIUrl":"https://doi.org/10.18502/ssu.v31i6.13477","url":null,"abstract":"Introduction: Non-Suicidal Self-Injury (NSSI) has high prevalence among the patients with psychiatric disorders. Self-Injury plays an important role in the treatment, prognosis and risk of suicide, which highlights the need for an appropriate tool to assess the nature and psychological functions of NSSI. Therefore, the aim of this study was to determine the psychometric properties of the Persian version of the Ottawa Self-Injury inventory (OSI) in hospitalized patients.
 Methods: The present study was a psychometric study based on analytical method. The research has been performed on 310 patients with non-suicidal self-injury who have been referred to Nekoei-Hedayati Hospital in Qom City. Sample group completed Persian version of the Ottawa Self-Injury inventory. Data were analyzed using SPSS-16 and Cronbach’s alpha coefficient, Content Validity Index (CVI) and Content Validity Ratio (CVR).
 Results: The results showed that content validity index in this study was more than 0.75 and content validity ratio for validity of questions was more than 0.79. The impact score of all items (Except for the tenth question) was higher than 1.5 that confirmed the face validity of inventory. The total Cronbach's alpha coefficient was calculated 0.71. Another result of this study was that 52% of patients reported at least one addictive characteristic.
 Conclusion: The finding showed that Persian version of Ottawa Self-Injury inventory has appropriate validity (face /content) and reliability in the inpatient population","PeriodicalId":17084,"journal":{"name":"Journal of Shahid Sadoughi University of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135138842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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