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Journal of Research in Pharmacy最新文献

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Formation of N-Oxide metabolites from isoniazid hydrazones of substituted benzaldehydes by hepatic washed pig microsomal preparations 猪肝洗微粒体制剂中取代苯甲醛异烟肼腙形成n -氧化物代谢物的研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.307
Göknil Pelin COŞKUN, Elif Göksu Algin, Jülide Cansu Karakoç, Başak Türk Erbul, M. Ülgen
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引用次数: 0
The extraction and determination of ellagic acid and resveratrol in blueberry species by HPLC-DAD and LC-MS/MS HPLC-DAD和LC-MS/MS法提取和测定蓝莓中鞣花酸和白藜芦醇的含量
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.313
S. Seyhan, G. Yalcin, S. Seyhan
{"title":"The extraction and determination of ellagic acid and resveratrol in blueberry species by HPLC-DAD and LC-MS/MS","authors":"S. Seyhan, G. Yalcin, S. Seyhan","doi":"10.29228/jrp.313","DOIUrl":"https://doi.org/10.29228/jrp.313","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69836699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibacterial and antibiofilm activity of Melaleuca alternifolia (tea tree) essential oil against colistin resistant Salmonella enterica serotypes isolated from poultry environmental specimens 互花千层树(茶树)精油对家禽环境标本中耐粘菌素肠炎沙门氏菌血清型的抑菌和抗菌活性研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.333
Merve Eylul Kiymaci, Merve Savluk, M. Gumustas, Mehmet Uvey, N. Unal
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引用次数: 0
Long-term administration of high doses of Hydroxychloroquine poses a risk of seizures 长期服用大剂量羟氯喹有癫痫发作的危险
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.323
Y. Panahi, Tannaz Haghgouie
The coronavirus spreading has led to the development of many drugs to prevent and treat it. One of these drugs is hydroxychloroquine, so this study was designed to investigate the potential side effects of the drug when used long-term and at high doses in male rats. Physiologically, 30 male Wistar rats were randomly divided into two groups: control and hydroxychloroquine (10, 50, 100, and 200 mg/kg) (n=6 per group). Hydroxychloroquine was administered orally for seven consecutive days. On the seventh day, 30 minutes after receiving hydroxychloroquine, the animals were anesthetized with a combination of ketamine (70 mg/kg) and xylazine (7 mg/kg), the animal's head was fixed using a stereotaxic device, and an incision 1.5-2 cm long was made in the scalp. Drill the desired point with a perforated dental drill using the Paxinos coordinates (AP =-0.27, ML =-0.14, DV =-0.3). Pentylenetetrazol (80 mg/kg i.p.) was used to induce epileptiform activities. Finally, diazepam (10 mg/kg, i.p.) was given to reduce epileptiform activity. The number of seizure activities was reduced significantly (p<0.001) at dose of 10 mg/kg and significantly (p<0.001) increased at doses of 100 and 200 mg/kg. In contrast, the dose of 50 mg/kg had no discernible effect. Giving male rats high doses of oral hydroxychloroquine for one week has biphasic effects on the number of pentylenetetrazol-induced seizure activities. As a result, it has protective effects in low and stimulant effects in high doses. © 2023 Marmara University Press ISSN: 2630-6344.
冠状病毒的传播导致了许多预防和治疗药物的开发。其中一种药物是羟氯喹,因此本研究旨在调查该药物在雄性大鼠中长期高剂量使用时的潜在副作用。生理上,30只雄性Wistar大鼠随机分为对照组和羟氯喹组(10、50、100、200 mg/kg),每组6只。羟氯喹连续7天口服。第7天,羟氯喹给药30分钟后,用氯胺酮(70 mg/kg)和噻嗪(7 mg/kg)联合麻醉动物,用立体定向装置固定动物头部,并在头皮上做1.5-2 cm长的切口。使用Paxinos坐标(AP =-0.27, ML =-0.14, DV =-0.3)用穿孔牙钻钻所需的点。戊四唑(80 mg/kg .p)诱导癫痫样活性。最后给予地西泮(10mg /kg, ig)以降低癫痫样活性。10 mg/kg剂量组癫痫发作次数显著减少(p<0.001), 100和200 mg/kg剂量组癫痫发作次数显著增加(p<0.001)。相反,50 mg/kg的剂量没有明显的影响。给雄性大鼠高剂量口服羟氯喹一周,对戊四唑诱发的癫痫发作次数有双相效应。因此,低剂量时具有保护作用,高剂量时具有刺激作用。©2023马尔马拉大学出版社ISSN: 2630-6344。
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引用次数: 0
Is it possible to improve antioxidant activity of curcumin with the structure of lipid- based nanocarriers? 脂基纳米载体结构能否提高姜黄素的抗氧化活性?
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.338
Gulin Amasya, Omer Yedikaya, Ulya Badilli, N. Ozdemir
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引用次数: 0
The Role of Endothelin Axis in Cancer Treatment and Its Position in Therapeutic Strategies 内皮素轴在肿瘤治疗中的作用及其在治疗策略中的地位
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.330
Nadir Gül
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引用次数: 0
Additives screening for the formulation of solid lipid nanoparticles of alpha-mangostin α -山竹苷固体脂质纳米颗粒配方添加剂筛选
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.361
Nagendra Babu VUTTI, S. K. R. Gudhanti, R. R. Alavala, P. K. Desu, Roja Rani Budha, Kishore Babu Govada, Durga Prasad Arja, Nagendra Ch
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引用次数: 1
pH-dependent pulsatile delivery of Ambrisentan for the treatment of hypertension 安布里森坦治疗高血压的ph依赖性搏动给药
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.365
A. Kanugo, Ronit Dhage
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引用次数: 0
O/W microemulsion and hydrogel formulation of methotrexate and comparison of releasing studies 甲氨蝶呤O/W微乳与水凝胶配方及释药比较研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.367
Abdullah Levent ALPARSLAN, E. Karasulu, G. Y. Türkyilmaz, D. Uvey
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引用次数: 0
BACTERIOTHERAPY 细菌疗法
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.384
Zahraa Amer HASHIM
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引用次数: 0
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Journal of Research in Pharmacy
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