{"title":"Effects of Cornus mas L. on lipid peroxidation and anti-oxidative enzyme activity in high fat diet fed rats","authors":"D. Kargın, Şule Aktaç, A. Yavuz, M. Cam","doi":"10.29228/jrp.325","DOIUrl":"https://doi.org/10.29228/jrp.325","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"127 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69837255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kurt, U. Şeker, M. Yazlık, Engin Er, M. Hürkul, S. Soker
{"title":"Identification of major phenolic compounds of Aloe vera and its protective effect on ovaries under oxidative stress in diabetic rats","authors":"S. Kurt, U. Şeker, M. Yazlık, Engin Er, M. Hürkul, S. Soker","doi":"10.29228/jrp.348","DOIUrl":"https://doi.org/10.29228/jrp.348","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69837730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of the anticancer effects of some plant seed oils with medicinal uses","authors":"Yener Kurman, Görkem Dülger, Ö. Pasin","doi":"10.29228/jrp.444","DOIUrl":"https://doi.org/10.29228/jrp.444","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"51 5 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: The present study describes the principles of systematic Quality by design (QbD) approach for the development of RP-HPLC method for the quantification of Bupivacaine hydrochloride (BUP) in bulk and in-house developed nanostructured lipid carriers (NLCs). Initially analytical target profile (ATP), and critical analytical attributes (CAAs) were identified. Primary assessment studies were checked using Plackett-Burman Design. Further optimization studies were performed by applying Box-Behnken design. The Shimadzu C-18 column (250mm x 4.6mm i.d., 5µm particle size) was utilized for reversed-phase chromatographic separation with a mobile phase comprising a mixture of acetonitrile (ACN) and 0.1% ortho phosphoric acid (OPA) (pH 2.04) in 69.45:30.55 (% v/v). The flow rate was 0.805mL/min at a λ max of 214 nm and an injection volume of 12µL. The new developed method was validated according to the guidelines given by International Conference on Harmonization which revealed linearity between 25 to 80µg/ml and r 2 = 0.999. The result of % RSD was 0.38 and 0.44 respectively for high degree of intraday and interday precision. As per the new method the LOD and LOQ is 0.900µg/ml and 2.72µg/ml, respectively. Further the validated method was also applied for the estimation of BUP in NLCs formulation, which showed no interference of any formulation excipients. The studies demonstrated that the new method is rapid, simple, selective, and reproducible for the estimation of pure drug and in-house developed NLCs.
{"title":"QbD based approach to RP-HPLC method development and validation of Bupivacaine hydrochloride in bulk and in-house developed nanostructured lipid carriers","authors":"Sarfaraz Khan, F. Khan","doi":"10.29228/jrp.475","DOIUrl":"https://doi.org/10.29228/jrp.475","url":null,"abstract":": The present study describes the principles of systematic Quality by design (QbD) approach for the development of RP-HPLC method for the quantification of Bupivacaine hydrochloride (BUP) in bulk and in-house developed nanostructured lipid carriers (NLCs). Initially analytical target profile (ATP), and critical analytical attributes (CAAs) were identified. Primary assessment studies were checked using Plackett-Burman Design. Further optimization studies were performed by applying Box-Behnken design. The Shimadzu C-18 column (250mm x 4.6mm i.d., 5µm particle size) was utilized for reversed-phase chromatographic separation with a mobile phase comprising a mixture of acetonitrile (ACN) and 0.1% ortho phosphoric acid (OPA) (pH 2.04) in 69.45:30.55 (% v/v). The flow rate was 0.805mL/min at a λ max of 214 nm and an injection volume of 12µL. The new developed method was validated according to the guidelines given by International Conference on Harmonization which revealed linearity between 25 to 80µg/ml and r 2 = 0.999. The result of % RSD was 0.38 and 0.44 respectively for high degree of intraday and interday precision. As per the new method the LOD and LOQ is 0.900µg/ml and 2.72µg/ml, respectively. Further the validated method was also applied for the estimation of BUP in NLCs formulation, which showed no interference of any formulation excipients. The studies demonstrated that the new method is rapid, simple, selective, and reproducible for the estimation of pure drug and in-house developed NLCs.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intranasal Oleic acid-based nanoemulsion of Diazepam: design, formulation and in-vitro evaluation","authors":"Yousif K. YOUNIS, S. N. A. Alhammid","doi":"10.29228/jrp.335","DOIUrl":"https://doi.org/10.29228/jrp.335","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"122 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69837197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Formulation of an anti-aging cream containing Alteromonas ferment extract and evaluation of the effect on collagen concentration","authors":"G. Gedik","doi":"10.29228/jrp.370","DOIUrl":"https://doi.org/10.29228/jrp.370","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69838517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NANOBIOMATERIALS FOR DRUG DELIVERY","authors":"Gulsah GEDIK","doi":"10.29228/jrp.503","DOIUrl":"https://doi.org/10.29228/jrp.503","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136208688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gülsüm YILDIZ, Betül DEMİRCİ, Halide Edip TEMEL, Neşe KIRIMER
{"title":"Origanum minutiflorum O. Schwarz et P. H. Davis essential oil: enzyme inhibitory activities and chemical composition.","authors":"Gülsüm YILDIZ, Betül DEMİRCİ, Halide Edip TEMEL, Neşe KIRIMER","doi":"10.29228/jrp.498","DOIUrl":"https://doi.org/10.29228/jrp.498","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135599402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antiepileptic Effect of Musa paradisiaca Stem Juice on Pentylenetetrazole (PTZ)-induced Seizures in Albino Rats","authors":"Sabastine Chinweike UGWUOKE, Valentine Odirachukwumma NWANELO, Martins Obinna OGUGOFOR, Obiora Celestine UGWU, Chioma Assumpta ANOSIKE","doi":"10.29228/jrp.398","DOIUrl":"https://doi.org/10.29228/jrp.398","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135686177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：