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NANOBIOMATERIALS FOR DRUG DELIVERY 用于药物递送的纳米生物材料
Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.503
Gulsah GEDIK
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引用次数: 0
Formulation and evaluation of acetazolamide loaded in–situ gel for the treatment of glaucoma 乙酰唑胺原位凝胶治疗青光眼的制备与评价
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.291
Fulchan Ali, Sk Habibullah, Yashwant Giri, A. Behera, B. Mohanty
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引用次数: 1
Docking-based workflow and ADME prediction of some compounds in Curcuma longa and Andrographis paniculata as polymerase PA-PB1 inhibitors of influenza A/H5N1 virus 姜黄和穿心莲中某些化合物作为甲型流感/H5N1病毒聚合酶PA-PB1抑制剂的对接工作流程和ADME预测
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.305
Sitti Nur Aidah Lya CITRA, A. Arfan, Armid Alroem, Laode Santiaji Bande, I. Irnawati, M. Arba
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引用次数: 2
Euphorbia neriifolia L. phytochemical lead compounds discovered using pharmacoinformatic methods as possible SARS CoV-2 main protease inhibitors 利用药物信息学方法发现的植物化学先导化合物可能是SARS CoV-2主要蛋白酶抑制剂
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.300
V. Malviya, M. Tawar, Prashant J. Burange, Ritu A. Bairagi, Vaibhav Bhadange, Chaitanya Vikhar
The corona virus (CoV) family's emerging SARS-CoV-2 strain potentially causes one of the most catastrophic COVID-19 pandemics in mankind. Other than vaccines for preventing SARS-CoV-2 infection, no selective drugs are available to treat the disease caused by the SARS-CoV-2. The main protease (Mpro) of SARS-CoV-2 plays a critical role in viral replication, and inhibiting the protease can hamper the virus's replication and infection process. Thus, we aimed to identify SARS-CoV-2 main protease (Mpro) inhibitors from Euphorbia neriifolia. Primarily, a total of 31 compounds were selected through wide literature study and the Indian Medicinal Plants, Phytochemistry and Therapeutics (IMPPAT) server. Current advances in computer-aided drug discovery includes molecular docking, pharmacokinetics, drug properties, toxicity analysis and molecular dynamic (MD) simulation were applied in characterization and identification of possible lead compounds in E. neriifolia. The compound's screening through molecular docking resulted in four phytochemicals, viz., CID: 5316673, CID: 102316539, CID: 101257, and CID: 9547213 exhibiting higher binding affinity of-8.461,-7.355,-6.404, and-6.382 kcal/mol, respectively, to the active site of the target Mpro. Subsequently, these four phytochemicals exhibited good pharmacokinetics and drug properties without toxicity. A MD simulation confirmed the binding stability of four phytochemicals to the Mpro. Our study identified four phytochemicals (CID: 5316673, CID: 102316539, CID: 101257, and CID: 9547213) can be developed as treatment option for SARS-CoV-2 disease related complications. Further in vitro and in vivo screening of the anti-SARS-CoV-2 effectiveness of E. neriifolia, as well as future clinical studies, are encouraged. © 2023 Marmara University Press.
冠状病毒(CoV)家族新出现的SARS-CoV-2毒株可能导致人类最具灾难性的COVID-19大流行之一。除了预防SARS-CoV-2感染的疫苗外,没有选择性药物可用于治疗SARS-CoV-2引起的疾病。SARS-CoV-2的主要蛋白酶(Mpro)在病毒复制过程中起着关键作用,抑制该蛋白酶可阻碍病毒的复制和感染过程。因此,我们的目的是鉴定来自大胡兰的SARS-CoV-2主要蛋白酶(Mpro)抑制剂。首先,通过广泛的文献研究和印度药用植物、植物化学和治疗学(IMPPAT)服务器筛选出31个化合物。利用分子对接、药代动力学、药物性质、毒性分析和分子动力学(MD)模拟等计算机辅助药物发现的最新进展,表征和鉴定了鸢尾草中可能的先导化合物。通过分子对接筛选得到4种植物化学物质,分别为CID: 5316673、CID: 102316539、CID: 101257和CID: 9547213,对目标Mpro活性位点的结合亲和力分别为8.461、-7.355、-6.404和6.382 kcal/mol。结果表明,这四种植物化学物质均表现出良好的药代动力学和无毒的药物特性。MD模拟证实了四种植物化学物质与Mpro的结合稳定性。我们的研究确定了四种植物化学物质(CID: 5316673, CID: 102316539, CID: 101257和CID: 9547213)可以作为SARS-CoV-2疾病相关并发症的治疗选择。鼓励进一步在体外和体内筛选鸢尾草抗sars - cov -2的有效性,以及未来的临床研究。©2023马尔马拉大学出版社
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引用次数: 0
Knowledge and consumption frequency of probiotics and fermented foods in elite volleyball players-A pilot study 优秀排球运动员益生菌及发酵食品知识及食用频率的初步研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.334
Yonca Sevim, Hande Nur Onur Öztürk, M. Ergün
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引用次数: 1
Elucidation of Antidiabetic Mechanism of Centella asiatica and Zingiber officinale- An In-vitro and In-vivo approach 积雪草和生姜抗糖尿病作用机制的体外和体内研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.324
Syed Sagheer AHMED, R. M
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引用次数: 2
In vitro and ex vivo assessments of surfactant-free topical curcumin emulgel 不含表面活性剂的局部姜黄素凝胶的体外和离体评价
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.336
Ahmet Doğan ERGİN, Özge Inal, Abdülkerim Barakat
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引用次数: 0
The combination of Luvunga sarmentosa (BI.) and Eurycoma longifolia Jackhydro-alcoholic extract as a source of antioxidant and analgesic agent 木犀草与长叶芡实水醇提取物联合作为抗氧化镇痛剂的研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.347
Achmad Fuad Hafid, Hilkatul Ilmi, Utami Islamiati, Hanifah Khairun Nisa, L. Tumewu, Myrna Adianti, T. Wahyuni, S. Suciati, A. Widyawaruyanti
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引用次数: 0
Development of biosynthesized silver nanoparticles from Cinnamomum tamala for anti-oxidant, anti-microbial and anti-cancer activity 肉桂生物合成纳米银抗氧化、抗微生物和抗癌活性的研究
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.359
Laxman S Vijapur, Y. Srinivas, Anita R. Desai, A. Gudigennavar, Somalingesh L Shidramshettar, Pooja Yaragattimath
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引用次数: 1
Evaluation of the Knowledge, Practices, Attitudes and Barriers of Community Pharmacists toward Oral Health and Dental Care in North Cyprus 北塞浦路斯社区药剂师对口腔健康和牙科保健的知识、做法、态度和障碍的评估
IF 0.8 Q4 PHARMACOLOGY & PHARMACY Pub Date : 2023-01-01 DOI: 10.29228/jrp.375
Meryem Deniz AYDIN, N. Birand, İffet Yazici
: Background: Community pharmacists have an effective role in improving and promoting oral health and dental care. Patients could receive counselling from community pharmacists about oral health and dental care after dentists’ examinations. Therefore, pharmacists need to develop competency in promoting oral health as part of their health promotion role. Methodology: This study was a cross-sectional questionnaire-based study carried out between December 2020 to January 2021 among community pharmacists to evaluate the knowledge, practices, attitudes, and barriers of community pharmacists for oral health and dental care in North Cyprus. Result: There were 128 of community pharmacies in Nicosia, North Cyprus. Only 104 (81.25%) of the community pharmacists accepted to participate in this study. Seventy-three of the participants agreed that they would like to play a more active role in promoting and improving oral health. Almost all; 102 (98.1%) agreed that oral health and dental care education should be included in the curriculum of pharmacy, while 78 (75%) and 61 (58.7%) of them feel unconfident when they were giving advice for oral cancer and oral ulcer, respectively. There was no association between demographic factors and the attitude of the community pharmacists toward oral health care. Conclusion: This study has shown that community pharmacists do not feel confident when they are giving oral health information about oral ulcers, oral cancer, and discoloured teeth. Most of the community pharmacists agreed that oral health and dental care education should be included in the curriculum of pharmacy.
背景:社区药师在改善和促进口腔健康和牙科保健方面发挥着有效作用。病人在接受牙医检查后,可向社区药剂师咨询口腔健康及牙齿护理。因此,药剂师需要发展促进口腔健康的能力,作为其健康促进作用的一部分。方法:本研究是一项基于横截面问卷的研究,于2020年12月至2021年1月在北塞浦路斯社区药剂师中开展,以评估社区药剂师在口腔健康和牙科保健方面的知识、做法、态度和障碍。结果:北塞浦路斯尼科西亚市共有社区药店128家。仅104名(81.25%)社区药师接受参与本研究。七十三名受访者表示希望在促进和改善口腔健康方面扮演更积极的角色。几乎所有;102人(98.1%)同意将口腔健康和牙齿保健教育纳入药学课程,78人(75%)和61人(58.7%)在提供口腔癌和口腔溃疡建议时感到不自信。人口统计学因素与社区药师对口腔卫生保健的态度无相关性。结论:本研究表明,社区药师在提供口腔溃疡、口腔癌、牙齿变色等口腔健康信息时缺乏自信。大多数社区药师认为应将口腔健康和牙齿保健教育纳入药学专业课程。
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引用次数: 2
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Journal of Research in Pharmacy
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