N. Saltan, Y. Köse, D. Kırcı, Fatih Göger, B. Demirci
{"title":"Chemical Profiling and Antimicrobial Activity of Essential Oils from Hypericum adenotrichum Spach. An Endemic Species","authors":"N. Saltan, Y. Köse, D. Kırcı, Fatih Göger, B. Demirci","doi":"10.29228/jrp.449","DOIUrl":"https://doi.org/10.29228/jrp.449","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Sweaty feet and foot odour are common nowadays. The existence of one or more of Staphylococcus epidermis, Bacillus subtilis and Propionibacterium Acnes on foot surface may trigger the generation of isovaleric and propionic acids, which in turn can cause a distinctive odor of feet. The present study tested susceptibility of Bacillus subtilis and Staphylococcus epidermidis to various oils and oil combinations. The outcome showed that a combination of lemon oil, neem oil and tulsi oil possessed synergistic antibacterial activity. A foot deodorizing gel containing a combination of lemon oil, neem oil, and tulsi oil; a gel base was prepared and tested for stability, organoleptic performance, antibacterial activity, irritation test, and deodorizing performance. The mixture of oils was found to reduce at least 6 logs of the primary populace of B. subtilis and S. epidermidis in 10 min. The lethal effect was found for at least 60 minutes. The gel formulation decreased at least 90% of the initial population of bacteria after 1 hour of contact when checked for days 0, 15, 30 and 60. The gel formulation also showed desired properties such as clarity, pourability, consistency, spreadability, quick absorption post application, non-stickiness and non-dryness, and absence of residue. The foot deodorizing gel formulation demonstrated antibacterial efficiency against the bacteria responsible for producing a strong foot odour.
{"title":"Foot Deodorizing Gel Formulation Having Antimicrobial Activity","authors":"Prashant R. PATANKAR, V. Chopade, P. Chaudhari","doi":"10.29228/jrp.415","DOIUrl":"https://doi.org/10.29228/jrp.415","url":null,"abstract":": Sweaty feet and foot odour are common nowadays. The existence of one or more of Staphylococcus epidermis, Bacillus subtilis and Propionibacterium Acnes on foot surface may trigger the generation of isovaleric and propionic acids, which in turn can cause a distinctive odor of feet. The present study tested susceptibility of Bacillus subtilis and Staphylococcus epidermidis to various oils and oil combinations. The outcome showed that a combination of lemon oil, neem oil and tulsi oil possessed synergistic antibacterial activity. A foot deodorizing gel containing a combination of lemon oil, neem oil, and tulsi oil; a gel base was prepared and tested for stability, organoleptic performance, antibacterial activity, irritation test, and deodorizing performance. The mixture of oils was found to reduce at least 6 logs of the primary populace of B. subtilis and S. epidermidis in 10 min. The lethal effect was found for at least 60 minutes. The gel formulation decreased at least 90% of the initial population of bacteria after 1 hour of contact when checked for days 0, 15, 30 and 60. The gel formulation also showed desired properties such as clarity, pourability, consistency, spreadability, quick absorption post application, non-stickiness and non-dryness, and absence of residue. The foot deodorizing gel formulation demonstrated antibacterial efficiency against the bacteria responsible for producing a strong foot odour.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Sourabh Kosey, Mohd Masih Uzzaman Khan
: Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions
{"title":"Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products","authors":"Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Sourabh Kosey, Mohd Masih Uzzaman Khan","doi":"10.29228/jrp.457","DOIUrl":"https://doi.org/10.29228/jrp.457","url":null,"abstract":": Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"IN-SILICO PHARMACOKINETICS PREDICTION OF MAJOR COUMARINS PRESENT IN AEGLE MARMELOS L.","authors":"Sagarika Dhamne, Pradum Shinde, S. Agrawal","doi":"10.29228/jrp.452","DOIUrl":"https://doi.org/10.29228/jrp.452","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Patole, Harshad S Kapare, J. Mahore, Rachana Bhimanwar, Devyani Awari, Pranali Jadhav
: Monoammonium glycyrrhizinate (MAG), a salt of glycyrrhizin, is reported for effective treatment of gastric disorders. The work was aimed to design and develop a gastro-retentive drug delivery system for MAG to delay its release in stomach by developing a stable raft with sufficient strength and acid-neutralizing potential. Preliminary, in-silico molecular docking study of MAG with the native ligand (Vonoprazan, a potential proton pump inhibitor) present in the gastric proton pump was performed. Docking studies predicted that MAG could bind to Vonoprazan binding site, indicating its ability to inhibit the gastric proton pump. The most desirable optimal formulation of raft forming tablets of MAG was anticipated with the desirability (0.819). The optimized formulation showed raft strength (8.61 ± 0.06 g), acid neutralizing capacity (11.19 ± 0.03 mEq) and in vitro release of MAG (69.11 ± 0.61% over 8h) indicating its suitability as a potential Gastro-retentive raft forming delivery system. The optimized formulation decreased gastric acid production and elevated gastric pH (p< 0.001.) in pylorus ligation induced gastric ulcers in animal model and demonstrated significant decrease in ulcer index (p< 0.001.) The developed raft-forming tablet of MAG could be a promising alternative to the existing synthetic agents to treat gastric ulcers.
{"title":"Development and evaluation of gastro retentive drug delivery system of monoammonium glycyrrhizinate for the management of gastric ulcer","authors":"V. Patole, Harshad S Kapare, J. Mahore, Rachana Bhimanwar, Devyani Awari, Pranali Jadhav","doi":"10.29228/jrp.472","DOIUrl":"https://doi.org/10.29228/jrp.472","url":null,"abstract":": Monoammonium glycyrrhizinate (MAG), a salt of glycyrrhizin, is reported for effective treatment of gastric disorders. The work was aimed to design and develop a gastro-retentive drug delivery system for MAG to delay its release in stomach by developing a stable raft with sufficient strength and acid-neutralizing potential. Preliminary, in-silico molecular docking study of MAG with the native ligand (Vonoprazan, a potential proton pump inhibitor) present in the gastric proton pump was performed. Docking studies predicted that MAG could bind to Vonoprazan binding site, indicating its ability to inhibit the gastric proton pump. The most desirable optimal formulation of raft forming tablets of MAG was anticipated with the desirability (0.819). The optimized formulation showed raft strength (8.61 ± 0.06 g), acid neutralizing capacity (11.19 ± 0.03 mEq) and in vitro release of MAG (69.11 ± 0.61% over 8h) indicating its suitability as a potential Gastro-retentive raft forming delivery system. The optimized formulation decreased gastric acid production and elevated gastric pH (p< 0.001.) in pylorus ligation induced gastric ulcers in animal model and demonstrated significant decrease in ulcer index (p< 0.001.) The developed raft-forming tablet of MAG could be a promising alternative to the existing synthetic agents to treat gastric ulcers.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"141 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
La Ode SUMARLIN, Achmad Tjachja Nugraha, A. Muawanah, Nur Ernita, Nurul Amilia
: Indonesian honey contains active compounds that have the potential as antioxidant and anticancer, especially as anticancer of the larynx through inhibition of HEp-2 cells. This study aims to determine the active compounds in longan honey and proposes the mechanism of action in inhibiting HEp-2 cells. The sample was used in the form of longan obtained from honey bee breeders in Central Java. Honey samples were extracted using methanol, and then liquid-liquid partitioning was carried out successively using n-hexane and ethyl acetate. Isolation and characterization of longan honey samples using FTIR and LC-MS/MS showed the presence of the following compounds: Xanthoxol glycosides, Santonin, Octadecanamide, Indole-3 carboxylaldehyde, 3,4-dimethoxycinnamic acid, Dimethyl esculetin, Tryptophan, O-acetyl-L-serine, D-glucose-6-phosphate, Feruloiltyramine, Lauryl diethanolamide, Taurine, 6-mercaptopurine, 3-(2,4-dichlorophenyl)-4-phenylcoumarin, 3',4'-dimethoxy-3-hydroxy-6- methylflavone and D-1-((3-carboxypropyl)amino)-1-deoxyfructose. The compounds in longan honey against HEp-2 cells is quercetin, 3,6-dimethoxycinnamic acid, phenyl coumarin, dimethyl esculetin, santonin, 6-mercaptopurine, and feruloyltyramine. The proposed mechanism of active compound in honey to inhibit HEp-2 cells in s everal ways including via caspase pathway and purine synthesis and other relevant mechanisms . However, this assumption needs to be tested further to obtain more precise information regarding the mechanism of inhibition of HEp-2 cells.
{"title":"Characterization of the compound of longan honey from indonesia using LC-MS/MS and FTIR and the mechanism of inhibition of HEp-2 cells","authors":"La Ode SUMARLIN, Achmad Tjachja Nugraha, A. Muawanah, Nur Ernita, Nurul Amilia","doi":"10.29228/jrp.483","DOIUrl":"https://doi.org/10.29228/jrp.483","url":null,"abstract":": Indonesian honey contains active compounds that have the potential as antioxidant and anticancer, especially as anticancer of the larynx through inhibition of HEp-2 cells. This study aims to determine the active compounds in longan honey and proposes the mechanism of action in inhibiting HEp-2 cells. The sample was used in the form of longan obtained from honey bee breeders in Central Java. Honey samples were extracted using methanol, and then liquid-liquid partitioning was carried out successively using n-hexane and ethyl acetate. Isolation and characterization of longan honey samples using FTIR and LC-MS/MS showed the presence of the following compounds: Xanthoxol glycosides, Santonin, Octadecanamide, Indole-3 carboxylaldehyde, 3,4-dimethoxycinnamic acid, Dimethyl esculetin, Tryptophan, O-acetyl-L-serine, D-glucose-6-phosphate, Feruloiltyramine, Lauryl diethanolamide, Taurine, 6-mercaptopurine, 3-(2,4-dichlorophenyl)-4-phenylcoumarin, 3',4'-dimethoxy-3-hydroxy-6- methylflavone and D-1-((3-carboxypropyl)amino)-1-deoxyfructose. The compounds in longan honey against HEp-2 cells is quercetin, 3,6-dimethoxycinnamic acid, phenyl coumarin, dimethyl esculetin, santonin, 6-mercaptopurine, and feruloyltyramine. The proposed mechanism of active compound in honey to inhibit HEp-2 cells in s everal ways including via caspase pathway and purine synthesis and other relevant mechanisms . However, this assumption needs to be tested further to obtain more precise information regarding the mechanism of inhibition of HEp-2 cells.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Noura Gheraissa, A. Chemsa, Nezar Cherrada, Erol Ebru, Eman Ramadan Elsharkawy
: Phytochemicals, which are necessary for plants to adapt to their environment, offer an exciting source of medicinal products. This study focuses on the desert plant Anabasis oropediorum ( Chenopodiaceae ), which is native to calcareous sandy regions in North African countries and Palestine. This investigation is the first to shed light on the therapeutic nature of the methanolic extract of the aerial parts of A. oropediorum . A phytochemical screening analysis was conducted, including a quantitative estimate of the total phenols, flavonoids, flavonols, anthocyanins, hydrolyzable tannins, and condensed tannins. Antioxidant activity was evaluated in vitro using three methods: DPPH • scavenging, β -carotene bleaching, and anti-hemolytic assay. The antidiabetic activity was tested using two assays: non-enzymatic hemoglobin glycosylation and glucose uptake by yeast cells assay. Antibacterial activity was evaluated by the disc diffusion method, and anti-inflammatory activity was evaluated by the protein anti-denaturation method. Phytochemical screening revealed the presence of alkaloids, coumarins, cardiac glycosides, leuco-anthocyanins, mucilage, phenols, saponins, sterols, and terpenes. The quantitative analysis showed that the methanolic extract provided a high level of flavonoids (17.0±0.50 µ g QE/mg) and the total contents of tannins (5.3±0.04 µ g GAE/mg, 7.3±0.14 µ g CE/mg). Chlorogenic acid, p -coumaric acid, quercetin, and rutin were the phenolic compounds detected by RP-HPLC analysis. FTIR spectroscopy confirmed the presence of alkanes, aromatic compounds, and aliphatic amines in the methanolic extract. Biologically, this medicinal plant exhibited medium antioxidant activity, good in vitro antidiabetic activity, antibacterial activity against only Staphylococcus aureus , Listeria innocua , and Escherichia coli , and very good albumin protection activity from heat denaturation
{"title":"Anabasis oropediorum Maire. as a health-promoting source: Phytochemical content, in vitro antioxidant, antidiabetic, antibacterial, and anti-inflammatory potential","authors":"Noura Gheraissa, A. Chemsa, Nezar Cherrada, Erol Ebru, Eman Ramadan Elsharkawy","doi":"10.29228/jrp.474","DOIUrl":"https://doi.org/10.29228/jrp.474","url":null,"abstract":": Phytochemicals, which are necessary for plants to adapt to their environment, offer an exciting source of medicinal products. This study focuses on the desert plant Anabasis oropediorum ( Chenopodiaceae ), which is native to calcareous sandy regions in North African countries and Palestine. This investigation is the first to shed light on the therapeutic nature of the methanolic extract of the aerial parts of A. oropediorum . A phytochemical screening analysis was conducted, including a quantitative estimate of the total phenols, flavonoids, flavonols, anthocyanins, hydrolyzable tannins, and condensed tannins. Antioxidant activity was evaluated in vitro using three methods: DPPH • scavenging, β -carotene bleaching, and anti-hemolytic assay. The antidiabetic activity was tested using two assays: non-enzymatic hemoglobin glycosylation and glucose uptake by yeast cells assay. Antibacterial activity was evaluated by the disc diffusion method, and anti-inflammatory activity was evaluated by the protein anti-denaturation method. Phytochemical screening revealed the presence of alkaloids, coumarins, cardiac glycosides, leuco-anthocyanins, mucilage, phenols, saponins, sterols, and terpenes. The quantitative analysis showed that the methanolic extract provided a high level of flavonoids (17.0±0.50 µ g QE/mg) and the total contents of tannins (5.3±0.04 µ g GAE/mg, 7.3±0.14 µ g CE/mg). Chlorogenic acid, p -coumaric acid, quercetin, and rutin were the phenolic compounds detected by RP-HPLC analysis. FTIR spectroscopy confirmed the presence of alkanes, aromatic compounds, and aliphatic amines in the methanolic extract. Biologically, this medicinal plant exhibited medium antioxidant activity, good in vitro antidiabetic activity, antibacterial activity against only Staphylococcus aureus , Listeria innocua , and Escherichia coli , and very good albumin protection activity from heat denaturation","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajani Thoutreddy, Koteswara Rao Gsn, N. Malothu, C. Guntupalli, Pavani Sriram, R. R. Alavala
: Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs. Transdermal delivery of cubosomes is currently gaining more importance over conventional topical delivery of drugs. The proposed study aimed to produce Lidocaine hydrochloride loaded cubosomes. This study was designed to prepare various formulations of Lidocaine nano cubsomal dispersions at different concentrations of lipid and stabilizer using optimization technique. For the purpose of prolonging the duration of the local anaesthetic action, Lidocaine-loaded cubosomes were developed by bottom up method utilizing Glyceryl mono oleate and Poloxamer 407 in various ratios using the "Quality by Design" approach, 3 2 factorial design employing statistical software. Within the confidence intervals, the 3 2 statistical design was effective at forecasting the optimized formulation's composition. Surface morphology, particle size, drug content, poly dispersibility index, zeta potential, entrapment efficiency, and in vitro drug release studies were conducted on the prepared formulations. Several mathematical models were used to conduct and assess an in vitro drug release investigation. The maximal entrapment efficiency for the LH8 formulation, which was validated to have optimum cubosomes dispersion, was reported to be 78 % with vesicle size as 150 nm, Zeta potential 21.5 mV and Poly Dispersibility Index as 0.08 along with an in vitro drug release 80.03 % by the end of 24 hours. A stable dispersion with appreciable results of evaluation parameters of cubosomal dispersion was conferred with formulation LH8. Hence from amongst the nine formulations developed, it is concluded that LH8 is selected as the optimized dispersion to be incorporated into a gel formulation.
{"title":"Development and Evaluation of Lidocaine Hydrochloride Cubosomes directed by QbD","authors":"Rajani Thoutreddy, Koteswara Rao Gsn, N. Malothu, C. Guntupalli, Pavani Sriram, R. R. Alavala","doi":"10.29228/jrp.485","DOIUrl":"https://doi.org/10.29228/jrp.485","url":null,"abstract":": Cubosomes, which are modified cubic phase systems, are looking very promising as a method of delivering both hydrophilic and lipophilic drugs. Transdermal delivery of cubosomes is currently gaining more importance over conventional topical delivery of drugs. The proposed study aimed to produce Lidocaine hydrochloride loaded cubosomes. This study was designed to prepare various formulations of Lidocaine nano cubsomal dispersions at different concentrations of lipid and stabilizer using optimization technique. For the purpose of prolonging the duration of the local anaesthetic action, Lidocaine-loaded cubosomes were developed by bottom up method utilizing Glyceryl mono oleate and Poloxamer 407 in various ratios using the \"Quality by Design\" approach, 3 2 factorial design employing statistical software. Within the confidence intervals, the 3 2 statistical design was effective at forecasting the optimized formulation's composition. Surface morphology, particle size, drug content, poly dispersibility index, zeta potential, entrapment efficiency, and in vitro drug release studies were conducted on the prepared formulations. Several mathematical models were used to conduct and assess an in vitro drug release investigation. The maximal entrapment efficiency for the LH8 formulation, which was validated to have optimum cubosomes dispersion, was reported to be 78 % with vesicle size as 150 nm, Zeta potential 21.5 mV and Poly Dispersibility Index as 0.08 along with an in vitro drug release 80.03 % by the end of 24 hours. A stable dispersion with appreciable results of evaluation parameters of cubosomal dispersion was conferred with formulation LH8. Hence from amongst the nine formulations developed, it is concluded that LH8 is selected as the optimized dispersion to be incorporated into a gel formulation.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69840490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumin's poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation (SD). This study's objective was to understand drying temperature's effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105°C, 115°C, and 125°C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency (DE) was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SD's yield increases as inlet temperature increases, from 33.60% at 105°C to 35.75% at 115°C to 39.30% at 125°C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125°C fits the zero-order model.
{"title":"The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts","authors":"Siska Ayu PURNAMASARI, Dewi Setyaningsih","doi":"10.29228/jrp.420","DOIUrl":"https://doi.org/10.29228/jrp.420","url":null,"abstract":": After oral administration, low water solubility and rapid pre-systemic metabolism contribute to curcumin's poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be coupled with curcumin in a solid dispersion-based microparticle formulation (SD). This study's objective was to understand drying temperature's effect on the yield and dissolution behaviour of curcumin and piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105°C, 115°C, and 125°C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine were their defining characteristics, and the dissolution efficiency (DE) was used to compare the dissolution profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The results demonstrate that the SD's yield increases as inlet temperature increases, from 33.60% at 105°C to 35.75% at 115°C to 39.30% at 125°C. The dissolution of curcumin and piperine from the SD increases along with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine at almost used drying temperatures; however, the release of piperine from the SD prepared at 125°C fits the zero-order model.","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69839071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neusilin US2 based Liquisolid Compact technique for the enhancement of solubility and dissolution rate of Olmesartan: Box-Behnken design approach","authors":"A. Kanugo, Anushka Thanvi","doi":"10.29228/jrp.289","DOIUrl":"https://doi.org/10.29228/jrp.289","url":null,"abstract":"","PeriodicalId":17096,"journal":{"name":"Journal of Research in Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69836416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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