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Exploring geriatric assessment-driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer 探索以老年病学评估为导向的康复转诊模式及其对晚期癌症老年人功能结果和存活率的影响。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-02 DOI: 10.1111/jgs.19250
Rachelle Brick PhD, MSPH, OTR/L, Marielle Jensen-Battaglia PT, DPT, Brennan P. Streck PhD, RN, MPH, Lindsey Page PhD, MPH, Rachael Tylock MS, Jenna Cacciatore MS, Karen Mustian PhD, MPH, Jamil Khatri MD, Jeff Giguere MD, Elie G. Dib MD, MS, Supriya Mohile MD, MS, Eva Culakova PhD, MS

Background

Older adults with advanced cancer experience functional disability that warrants rehabilitation services; however, evidence indicates inconsistencies in referral. The purpose was to (1) identify predictors of geriatric assessment (GA)-driven referrals to rehabilitation services and (2) explore associations between referral and change in function, health-related quality of life (HRQoL), and overall survival among older adults with advanced cancer.

Methods

This was a secondary analysis (NCT020107443, UG1CA189961) of a nationwide GA clinical trial. Patients were older adults with advanced cancer who had at least one GA-defined physical performance or functional status impairment. Primary outcomes were oncologist-initiated discussion about or referral to rehabilitation services after the GA (Aim 1) and decline in activities of daily living (ADL), Instrumental ADL (IADL), and HRQoL within 3 months, and overall survival at 1 year (Exploratory Aims). Analyses included multivariable logistic regression and Cox proportional hazards models. Demographic and clinical factors were controlled for by using 1:1 propensity score matching.

Results

In total 265 patients were analyzed. After adjustment, impaired cognition (odds ratio [OR] = 2.25, p = 0.01), Karnofsky score indicating disability (OR = 2.86, p < 0.01), and receipt of monoclonal antibodies (OR = 1.95, p = 0.04) were associated with higher odds of referral. In contrast, polypharmacy was associated with lower odds of referral (OR = 0.31, p < 0.01). Referred patients were less likely to decline in ADL (OR 0.30, p = 0.07) and IADL (OR 0.64, p = 0.35), but more likely to decline in HRQoL (OR 1.20, p = 0.67) and have worse survival (HR 1.18, p = 0.62).

Conclusions

Cancer treatment, polypharmacy, cognition, and disability status likely influence oncologists' decision to refer for rehabilitation. Referral was not independently associated with change in functional disability, HRQoL, or survival. Future studies should evaluate patients' utilization of rehabilitation services post-referral and determine whether dose/timing of rehabilitation services influence clinical outcomes.

背景:晚期癌症患者中的老年人会出现功能障碍,需要接受康复服务;但有证据表明,转诊情况并不一致。研究目的是:(1) 确定老年评估(GA)驱动的康复服务转介的预测因素;(2) 探讨转介与晚期癌症老年人的功能变化、健康相关生活质量(HRQoL)和总体生存率之间的关系:这是一项全国性 GA 临床试验的二次分析(NCT020107443,UG1CA189961)。患者为晚期癌症老年人,至少有一项 GA 定义的身体表现或功能状态损伤。主要研究结果包括:GA后由肿瘤学家发起的关于康复服务的讨论或转诊(目标1)、3个月内日常生活活动(ADL)、工具性日常生活活动(IADL)和HRQoL的下降以及1年后的总生存率(探索性目标)。分析包括多变量逻辑回归和考克斯比例危险模型。人口统计学和临床因素通过1:1倾向评分匹配进行控制:共对 265 名患者进行了分析。经调整后,认知能力受损(几率比 [OR] = 2.25,P = 0.01)、Karnofsky 评分显示残疾(OR = 2.86,P 结论:这两个因素均与癌症治疗、多药治疗和药物滥用有关:癌症治疗、多药治疗、认知能力和残疾状况可能会影响肿瘤专家转诊康复的决定。转诊与功能性残疾、HRQoL 或生存率的变化并无独立关联。未来的研究应评估患者在转诊后对康复服务的利用情况,并确定康复服务的剂量/时间是否会影响临床结果。
{"title":"Exploring geriatric assessment-driven rehabilitation referral patterns and its influence on functional outcomes and survival in older adults with advanced cancer","authors":"Rachelle Brick PhD, MSPH, OTR/L,&nbsp;Marielle Jensen-Battaglia PT, DPT,&nbsp;Brennan P. Streck PhD, RN, MPH,&nbsp;Lindsey Page PhD, MPH,&nbsp;Rachael Tylock MS,&nbsp;Jenna Cacciatore MS,&nbsp;Karen Mustian PhD, MPH,&nbsp;Jamil Khatri MD,&nbsp;Jeff Giguere MD,&nbsp;Elie G. Dib MD, MS,&nbsp;Supriya Mohile MD, MS,&nbsp;Eva Culakova PhD, MS","doi":"10.1111/jgs.19250","DOIUrl":"10.1111/jgs.19250","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Older adults with advanced cancer experience functional disability that warrants rehabilitation services; however, evidence indicates inconsistencies in referral. The purpose was to (1) identify predictors of geriatric assessment (GA)-driven referrals to rehabilitation services and (2) explore associations between referral and change in function, health-related quality of life (HRQoL), and overall survival among older adults with advanced cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a secondary analysis (NCT020107443, UG1CA189961) of a nationwide GA clinical trial. Patients were older adults with advanced cancer who had at least one GA-defined physical performance or functional status impairment. Primary outcomes were oncologist-initiated discussion about or referral to rehabilitation services after the GA (Aim 1) and decline in activities of daily living (ADL), Instrumental ADL (IADL), and HRQoL within 3 months, and overall survival at 1 year (Exploratory Aims). Analyses included multivariable logistic regression and Cox proportional hazards models. Demographic and clinical factors were controlled for by using 1:1 propensity score matching.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total 265 patients were analyzed. After adjustment, impaired cognition (odds ratio [OR] = 2.25, <i>p</i> = 0.01), Karnofsky score indicating disability (OR = 2.86, <i>p</i> &lt; 0.01), and receipt of monoclonal antibodies (OR = 1.95, <i>p</i> = 0.04) were associated with higher odds of referral. In contrast, polypharmacy was associated with lower odds of referral (OR = 0.31, <i>p</i> &lt; 0.01). Referred patients were less likely to decline in ADL (OR 0.30, <i>p</i> = 0.07) and IADL (OR 0.64, <i>p</i> = 0.35), but more likely to decline in HRQoL (OR 1.20, <i>p</i> = 0.67) and have worse survival (HR 1.18, <i>p</i> = 0.62).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Cancer treatment, polypharmacy, cognition, and disability status likely influence oncologists' decision to refer for rehabilitation. Referral was not independently associated with change in functional disability, HRQoL, or survival. Future studies should evaluate patients' utilization of rehabilitation services post-referral and determine whether dose/timing of rehabilitation services influence clinical outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 1","pages":"136-149"},"PeriodicalIF":4.3,"publicationDate":"2024-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142565408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of body indices with mortality in older population: Japan Specific Health Checkups (J-SHC) Study 老年人身体指数与死亡率的关系:日本特定健康检查(J-SHC)研究。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-11-02 DOI: 10.1111/jgs.19244
Takaaki Kosugi MD, PhD, Masahiro Eriguchi MD, PhD, Hisako Yoshida PhD, Hiroyuki Tamaki MD, Takayuki Uemura MD, PhD, Hikari Tasaki MD, PhD, Riri Furuyama MD, Masatoshi Nishimoto MD, PhD, Masaru Matsui MD, PhD, Ken-ichi Samejima MD, PhD, Kunitoshi Iseki MD, PhD, Shouichi Fujimoto MD, PhD, Tsuneo Konta MD, PhD, Toshiki Moriyama MD, PhD, Kunihiro Yamagata MD, PhD, Ichiei Narita MD, PhD, Masato Kasahara MD, PhD, Yugo Shibagaki MD, PhD, Masahide Kondo MD, PhD, Koichi Asahi MD, PhD, Tsuyoshi Watanabe MD, PhD, Kazuhiko Tsuruya MD, PhD

Background

Obesity indices reflect not only fat mass but also muscle mass and nutritional status in older people. Therefore, they may not accurately reflect prognosis. This study aimed to investigate associations between a body shape index (ABSI), body mass index (BMI), and mortality in the general older population.

Methods

This nationwide observational longitudinal study included individuals aged between 65 and 74 years who underwent annual health checkups between 2008 and 2014. Exposures of interest were ABSI and BMI, and the primary outcome was all-cause mortality. Association between the ABSI and BMI quartile (Q1–4) and mortality was assessed using Cox regression analysis. A restricted cubic spline was also used to investigate nonlinear associations. The missing values were imputed using multiple imputation by chained equations.

Results

Among 315,215 participants, 5074 died during a median follow-up period of 42.5 (interquartile range: 26.2–59.3) months. Compared with ABSI Q1, ABSI Q3 and Q4 were associated with increased risk of mortality, with the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) of 1.13 (1.05–1.22) and 1.23 (1.13–1.35), respectively. Compared with BMI Q3, BMI Q1 and Q2 were associated with an increased risk of mortality, with aHRs and 95% CIs of 1.51 (1.39–1.65) and 1.12 (1.03–1.22), respectively. The impacts of these indices were greater in male than in female. The heatmap of the aHR for mortality by continuous ABSI and BMI showed that higher ABSI was consistently associated with higher mortality risk regardless of BMI, and that the combination of low BMI and high ABSI was strongly associated with increased mortality risk.

Conclusions

High ABSI and low BMI are additively associated with the risk of all-cause mortality in the general older population in Japan. Combination of ABSI and BMI is useful for evaluating mortality risk in older people.

背景:肥胖指数不仅能反映老年人的脂肪量,还能反映肌肉量和营养状况。因此,它们可能无法准确反映预后。本研究旨在调查体形指数(ABSI)、体重指数(BMI)与普通老年人口死亡率之间的关系:这项全国性的观察性纵向研究纳入了年龄在 65 岁至 74 岁之间、在 2008 年至 2014 年期间接受过年度健康检查的人群。研究关注的暴露因素是ABSI和体重指数,主要结果是全因死亡率。采用 Cox 回归分析评估了 ABSI 和 BMI 四分位数(Q1-4)与死亡率之间的关系。限制性三次样条曲线也用于研究非线性关联。缺失值通过链式方程进行多重估算:在 315215 名参与者中,有 5074 人在中位 42.5 个月(四分位间范围:26.2-59.3)的随访期间死亡。与 ABSI Q1 相比,ABSI Q3 和 Q4 与死亡风险增加有关,调整后的危险比 (aHR) 和 95% 置信区间 (CI) 分别为 1.13 (1.05-1.22) 和 1.23 (1.13-1.35)。与 BMI Q3 相比,BMI Q1 和 Q2 与死亡风险增加有关,aHRs 和 95% 置信区间分别为 1.51 (1.39-1.65) 和 1.12 (1.03-1.22)。这些指数对男性的影响大于女性。根据连续 ABSI 和体重指数绘制的死亡率 aHR 热图显示,无论体重指数如何,较高的 ABSI 始终与较高的死亡风险相关,而低体重指数和高 ABSI 的组合与死亡风险的增加密切相关:结论:在日本的普通老年人群中,高 ABSI 和低 BMI 与全因死亡风险呈叠加关系。结合 ABSI 和 BMI 可以评估老年人的死亡风险。
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引用次数: 0
Correction to “Attitudes on Participation in Clinical Drug Trials: A Nationally Representative Survey of Older Adults With Multimorbidity” 对 "参与临床药物试验的态度:对患有多种疾病的老年人的全国代表性调查"。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-30 DOI: 10.1111/jgs.19233

Schwartz JB, Liu R, Boscardin J, et al. Attitudes on participation in clinical drug trials: A nationally representative survey of older adults with multimorbidity. J Am Geriatr Soc. 2024;72(6):1717–1727. doi: 10.1111/jgs.18857

The authors have discovered an error in Table 2. In the highlighted row below, total n (%) is incorrect and should be: 632 (47.9%).

Afraid of side effects  632 (47.9)  346 (52.8)  286 (43.1)

We apologize for this error.

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引用次数: 0
Introduction for the 2024 Chinese Congress on Gerontology and Health Industry (CCGI) Abstracts 2024 年中国老年学与健康产业大会摘要 2024 年 11 月 1 日至 3 日,中华人民共和国海南省海口市。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-30 DOI: 10.1111/jgs.19221
Sean X. Leng MD, PhD, Xiao-Ying Li MD
<p>It is once again with great pleasure that we introduce the research work to be presented at the 2024 Chinese Congress on Gerontology and Health Industry (CCGI), which is published in abstract form in this issue of the Journal of the American Geriatrics Society (JAGS). The 2024 CCGI conference is the continuation of the annual national geriatrics and gerontology conference co-organized and co-sponsored by a number of major Chinese professional healthcare organizations including the Chinese Medical Association (CMA) Geriatrics Branch and China Health Promotion Foundation. This year's CCGI conference will be held on November 1–3. 2024 in the city of Haikou, China's island province Hainan. We have 115 quality abstracts to be included in this issue.</p><p>While COVID-19 pandemic is largely behind us, its impact on world economy and scientific conferences continues to be palpable. The current economic downturn and overseas regional conflicts create additional challenges. Despite these difficulties, the 2024 CCGI conference will be held in person and the research work to be presented at the conference is as robust as that presented at previous years' CCGI conferences. Similar to the previous 11 years, the work to be presented at this year's CCGI conference encompasses many important areas of geriatrics and gerontology, from basic aging research to geriatric syndromes; from clinical observation and large epidemiological studies to clinical trials; and from biological investigations to social and behavioral research. Unique to this year, it emphasizes palliative care, cardiovascular aging and diseases, systems approach for senior health, as well as socioeconomic determinants of aging care. It also includes a broad range of studies of basic and translational aging research, such as investigation into chronic cytomegalovirus (CMV) infection as a potential contributing factor to immunosenescence and age-related chronic inflammation, longitudinal cohort studies, mechanistic studies in animal models, and other types of studies including clinical trials for the prevention and treatment of common geriatric syndromes and age-related diseases. Moreover, almost 20% of the abstracts are submitted by researchers from other countries and regions including the United States, European countries (Germany, UK), South Korea, Macao, etc., demonstrating a robust international representation. The work described here will be presented in the form of oral presentation or poster at the conference. The conference will have similar number of symposia with individual symposium on translational aging research, common geriatric syndromes, prevention, rehabilitation, nutrition, geriatric nursing, traditional Chinese medicine, community geriatrics care, and long-term care, and so on. Publication of such exemplary work in geriatrics and gerontology in this supplement issue of JAGS will further enhance scientific and scholarly exchanges between colleagues in China and geriatrics and g
本期《美国老年医学会杂志》(JAGS)以摘要形式刊登了将在2024年中国老年学与健康产业大会(CCGI)上发表的研究成果。2024 年中国老年医学与健康产业大会(CCGI)是由中华医学会老年医学分会、中国健康促进基金会等多家中国主要专业医疗机构共同主办和协办的全国性老年医学与老年产业年会的延续。今年的 CCGI 会议将于 11 月 1 日至 3 日举行。今年的 CCGI 大会将于 2024 年 11 月 1 日至 3 日在中国海南省海口市举行。虽然COVID-19大流行病已基本过去,但其对世界经济和科学会议的影响依然明显。当前的经济衰退和海外地区冲突带来了更多的挑战。尽管存在这些困难,2024年CCGI会议仍将亲自举行,会上展示的研究工作与往年CCGI会议上展示的研究工作一样强劲。与前11年类似,今年CCGI会议上将要展示的工作涵盖了老年医学和老年学的许多重要领域,从基础老龄化研究到老年综合症;从临床观察和大型流行病学研究到临床试验;从生物调查到社会和行为研究。今年的独特之处在于,它强调姑息治疗、心血管衰老和疾病、老年健康的系统方法以及老年护理的社会经济决定因素。此外,还包括广泛的基础和转化性老龄化研究,如慢性巨细胞病毒(CMV)感染作为免疫衰老和老年慢性炎症潜在诱因的调查、纵向队列研究、动物模型的机理研究,以及其他类型的研究,包括预防和治疗常见老年综合症和老年相关疾病的临床试验。此外,近 20% 的摘要是由其他国家和地区的研究人员提交的,包括美国、欧洲国家(德国、英国)、韩国、澳门等,显示了强大的国际代表性。这里介绍的工作将以口头报告或海报的形式在大会上展示。会议还将举办数量相近的专题讨论会,分别就老龄化转化研究、常见老年综合症、预防、康复、营养、老年护理、中医、社区老年护理和长期护理等内容展开讨论。在《老年医学杂志》增刊上发表这些老年病学和老年医学领域的典范之作,将进一步加强中国同行与美国及世界各地老年病学和老年医学界的科学和学术交流。为此,我们要再次感谢JAGS的领导层,特别是现任主编Joseph Ouslander博士、美国老年医学会首席执行官Nancy Lundebjerg女士以及Wiley公司的Kurt Polesky先生,感谢他们为本刊的成功发行所给予的支持和付出的努力。正如前几期 JAGS CCGI 会议增刊所指出的,1-8 中国是世界上老龄人口最多的国家,发展高质量的老年医学护理和老龄化研究是中国的国家优先事项。虽然国家医疗政策已经规定所有综合医院都必须提供老年医学护理服务,但对老年医学人才培养的迫切需求仍然是前所未有的。为了解决这一难以克服的需求,在2015年和2016年完成国家高级培训班的中国医师协会老年医学分会成员通过继续医学教育(CME)和其他机制,继续在中国各地开展老年医学培训工作。自2011年起每年举办的北京协和医院-约翰霍普金斯老年医学研讨会,也已经并将继续作为一个重要的老年医学培训平台。然而,中国老年医学发展的道路曲折而漫长,任重而道远。目前,我们正致力于发展高质量的老年医学临床和教育项目,以及推进老年医学临床和转化研究。国际学术交流与合作作为中国老年医学发展的催化剂至关重要,但也充满挑战,尤其是在当前的政治环境下。 美国医学慈善机构,如伊尔玛和保罗-米尔斯坦老年健康项目下的米尔斯坦亚美医学合作基金会(MMAAP),已经并将继续提供私人资金支持中国的临床和研究项目。同样,《老年医学杂志》多年来通过发表同类特别文章9-11,向美国和世界各地的同行介绍中国的人口老龄化情况和老年医学的最新发展,起到了带头作用。考虑到除医疗保健外,老年人对其他支持服务和产品的需求,CCGI大会还组织了国内外医疗保健行业的合格养老服务项目、设备、辅助器具和其他相关产品的大型展览。因此,今年的 CCGI 会议仍将是一个重要的平台和有益的网络,不仅可以进行科学和学术交流,还可以在老年保健和医疗保健行业发展潜在的伙伴关系和合作。今年早些时候,中国刚刚宣布了允许其他国家的实体在中国开发、管理和拥有医疗保健业务的政策,这一点显得尤为重要和及时。为了鼓励和欢迎美国老年医学学会和美国老年学学会的会员以及除美国以外的其他国家的研究人员参加会议,会议设立了一个国际研讨会。CCGI 组委会将继续执行免收会议注册费的政策,并承担与会议相关的中国差旅费用(即会议期间的酒店住宿和餐饮)。正如我们在前几期 JAGS CCGI 会议增刊中所做的那样,我们承认继续开展此类国际性工作所面临的挑战。我们再次对中国医师协会老年医学分会和CCGI组委会的领导表示敬意,感谢他们为这个在中国相对较新但正在崛起的学科争取到了资金、征集到了高质量的论文摘要,并进行了严格的科学同行评审。尽管我们从以往的 CCGI 会议中积累了经验,并尽了最大努力进行审阅和编辑,但有些摘要在翻译成英文时仍不可避免地存在语言错误。因此,我们希望读者能够理解我们的疏忽。我们也希望读者能提出反馈意见,以便我们今后进一步改进。为此,我们要感谢中美两国参与这项重要工作的所有人。我们再次预祝2024年CCGI会议取得圆满成功!
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引用次数: 0
Abstracts for JGS Chinese Supplement 2024 年中国老年学与健康产业大会摘要 2024 年 11 月 1 日至 3 日,中华人民共和国海南省海口市。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-30 DOI: 10.1111/jgs.19222
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引用次数: 0
Vaccinations in older adults: Optimization, strategies, and latest guidelines 老年人的疫苗接种:优化、策略和最新指南。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-29 DOI: 10.1111/jgs.19243
Aileen R. Pangilinan MD, Sharon A. Brangman MD, Stefan Gravenstein MD MPH, Kenneth Schmader MD, George A. Kuchel MD

This article is a summary of the first AGS Symposium entitled “Update on Vaccination Strategies for Older Adults: Matching the Approach to the Individual and the Care Setting.” Given declines in host defenses and immune function with aging, vaccinations play a pivotal role in fortifying older adults against preventable infections, resulting diseases, disability, and death. Current guidelines generally list recommendations applicable for an average older adult of a given chronological age. However, growing evidence indicates that heterogeneity in terms of factors as varied as biological sex, frailty, functional status, and multimorbidity may impact vaccine responses and clinical outcomes. As a result, clinicians will increasingly need to take these additional factors into consideration as they seek to improve outcomes through improved targeting of such aging-related heterogeneity. Moreover, efforts at protecting older citizens through vaccination must also include strategies to overcome barriers to the adoption of vaccine recommendations in varied settings including long-term care. This 2023 AGS Plenary Symposium sought to commence a broader dialogue across AGS and beyond on optimizing vaccinations for older adults, ensuring not only extended lifespans but also healthier and more active lives. This report is not a systematic review, and thus should not be considered comprehensive.

本文是题为 "老年人疫苗接种策略的最新进展 "的第一届 AGS 研讨会的摘要:因人而异,因护理环境而异 "的第一次 AGS 研讨会摘要。随着年龄的增长,宿主的防御能力和免疫功能都会下降,因此接种疫苗在加强老年人预防可预防的感染、疾病、残疾和死亡方面发挥着关键作用。目前的指南一般列出了适用于特定年龄段的普通老年人的建议。然而,越来越多的证据表明,生理性别、虚弱程度、功能状态和多病等不同因素的异质性可能会影响疫苗反应和临床结果。因此,临床医生越来越需要考虑到这些额外的因素,通过改善与老龄化相关的异质性来提高疗效。此外,通过接种疫苗来保护老年公民的工作还必须包括制定战略,以克服在包括长期护理在内的各种环境中采用疫苗建议的障碍。本次 2023 AGS 全体研讨会旨在就优化老年人疫苗接种问题在 AGS 及其他机构展开更广泛的对话,以确保老年人不仅能延长寿命,而且能过上更健康、更积极的生活。本报告并非系统性综述,因此不应被视为全面性报告。
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引用次数: 0
Differences in setting of initial dementia diagnosis among fee-for-service Medicare beneficiaries 付费医疗保险受益人初次诊断痴呆症的背景差异。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-22 DOI: 10.1111/jgs.19236
Elizabeth M. White APRN, PhD, Thomas Bayer MD, Cyrus M. Kosar PhD, Christopher M. Santostefano RN, MPH, Ulrike Muench RN, PhD, Hyesung Oh MPH, MBA, Emily A. Gadbois PhD, Pedro L. Gozalo PhD, Momotazur Rahman PhD

Background

Accurate and timely diagnosis of dementia is necessary to allow affected individuals to make informed decisions and access appropriate resources. When dementia goes undetected until a hospitalization or nursing home stay, this could reflect delayed diagnosis or misdiagnosis, and may reflect underlying disparities in healthcare access.

Methods

In this retrospective cohort study, we used 2012–2020 Medicare claims and other administrative data to examine variation in setting of dementia diagnosis among fee-for-service Medicare beneficiaries with an initial claims-based dementia diagnosis in 2016. We used multinomial logistic regression to evaluate the association of person and geographic factors with diagnosis location, and Cox proportional hazards regression to examine 4-year survival relative to diagnosis location.

Results

Among 754,204 Medicare beneficiaries newly diagnosed with dementia in 2016, 60.3% were diagnosed in the community, 17.2% in hospitals, and 22.5% in nursing homes. Adjusted 4-year survival rates were significantly lower among those diagnosed in hospitals [−16.1 percentage points (95% CI: −17.0, −15.1)] and nursing homes [−16.8 percentage points (95% CI: −17.7, −15.9)], compared to those diagnosed in the community. Community-diagnosed beneficiaries were more often female, younger, Asian or Pacific Islander, Native American or Alaskan Native, Hispanic, had fewer baseline hospitalizations and higher homecare use, and resided in wealthier ZIP codes. Rural beneficiaries were more likely to be diagnosed in hospitals.

Conclusions

Many older adults are diagnosed with dementia in a hospital or nursing home. These individuals have significantly lower survival than those diagnosed in the community, which may indicate diagnosis during an acute illness or care transition, or at a later disease stage, all of which are suboptimal. These results highlight the need for improved dementia screening in the general population, particularly for individuals in rural areas and communities with higher social deprivation.

背景:准确及时地诊断痴呆症对患者做出明智决策和获得适当资源十分必要。如果痴呆症直到住院或入住疗养院时才被发现,这可能反映出诊断延迟或误诊,也可能反映出医疗保健服务的潜在差异:在这项回顾性队列研究中,我们使用了 2012-2020 年的医疗保险报销单和其他管理数据,研究了 2016 年初次报销单诊断为痴呆症的付费医疗保险受益人中痴呆症诊断环境的变化。我们使用多叉逻辑回归评估了个人和地理因素与诊断地点的关联,并使用 Cox 比例危险回归检验了与诊断地点相关的 4 年生存率:在2016年新确诊为痴呆症的754204名医疗保险受益人中,60.3%在社区确诊,17.2%在医院确诊,22.5%在疗养院确诊。与在社区确诊的患者相比,在医院确诊的患者[-16.1个百分点(95% CI:-17.0,-15.1)]和疗养院确诊的患者[-16.8个百分点(95% CI:-17.7,-15.9)]调整后的4年生存率明显较低。社区确诊的受益人多为女性、年轻、亚裔或太平洋岛民、美国原住民或阿拉斯加原住民、西班牙裔、基线住院次数较少、家庭护理使用率较高、居住在较富裕的邮政编码内。农村受益人更有可能在医院确诊:结论:许多老年人是在医院或养老院被诊断出患有痴呆症的。这些人的存活率明显低于在社区确诊的患者,这可能表明他们是在急性疾病或护理过渡期间或疾病晚期确诊的,所有这些情况都不理想。这些结果凸显了在普通人群中改进痴呆症筛查的必要性,尤其是对农村地区和社会贫困程度较高的社区的痴呆症患者而言。
{"title":"Differences in setting of initial dementia diagnosis among fee-for-service Medicare beneficiaries","authors":"Elizabeth M. White APRN, PhD,&nbsp;Thomas Bayer MD,&nbsp;Cyrus M. Kosar PhD,&nbsp;Christopher M. Santostefano RN, MPH,&nbsp;Ulrike Muench RN, PhD,&nbsp;Hyesung Oh MPH, MBA,&nbsp;Emily A. Gadbois PhD,&nbsp;Pedro L. Gozalo PhD,&nbsp;Momotazur Rahman PhD","doi":"10.1111/jgs.19236","DOIUrl":"10.1111/jgs.19236","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Accurate and timely diagnosis of dementia is necessary to allow affected individuals to make informed decisions and access appropriate resources. When dementia goes undetected until a hospitalization or nursing home stay, this could reflect delayed diagnosis or misdiagnosis, and may reflect underlying disparities in healthcare access.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective cohort study, we used 2012–2020 Medicare claims and other administrative data to examine variation in setting of dementia diagnosis among fee-for-service Medicare beneficiaries with an initial claims-based dementia diagnosis in 2016. We used multinomial logistic regression to evaluate the association of person and geographic factors with diagnosis location, and Cox proportional hazards regression to examine 4-year survival relative to diagnosis location.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 754,204 Medicare beneficiaries newly diagnosed with dementia in 2016, 60.3% were diagnosed in the community, 17.2% in hospitals, and 22.5% in nursing homes. Adjusted 4-year survival rates were significantly lower among those diagnosed in hospitals [−16.1 percentage points (95% CI: −17.0, −15.1)] and nursing homes [−16.8 percentage points (95% CI: −17.7, −15.9)], compared to those diagnosed in the community. Community-diagnosed beneficiaries were more often female, younger, Asian or Pacific Islander, Native American or Alaskan Native, Hispanic, had fewer baseline hospitalizations and higher homecare use, and resided in wealthier ZIP codes. Rural beneficiaries were more likely to be diagnosed in hospitals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Many older adults are diagnosed with dementia in a hospital or nursing home. These individuals have significantly lower survival than those diagnosed in the community, which may indicate diagnosis during an acute illness or care transition, or at a later disease stage, all of which are suboptimal. These results highlight the need for improved dementia screening in the general population, particularly for individuals in rural areas and communities with higher social deprivation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 1","pages":"39-49"},"PeriodicalIF":4.3,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Capacity assessment for euthanasia in dementia: A qualitative study of 60 Dutch cases 痴呆症患者安乐死的能力评估:对 60 个荷兰案例的定性研究。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-21 DOI: 10.1111/jgs.19218
Arne van den Bosch BSc, Radboud M. Marijnissen MD, PhD, Denise J. C. Hanssen PhD, Richard C. Oude Voshaar MD, PhD

Background

The number of patients with dementia who are granted euthanasia or assisted suicide (EAS) increases yearly in the Netherlands. By law, patients need to be decisionally competent or have an advance directive. Assessment of decisional capacity is challenging as dementia progressively affects cognitive performance. We aimed to assess qualitatively which factors, and how, influence the judgment of decisional capacity in EAS cases with dementia.

Methods

We performed a qualitative study of 60 dementia EAS case summaries published by the Dutch regional euthanasia review committees between 2012 and 2021. Included reports were evaluated using the grounded theory approach. All quotes related to decisional capacity were coded independently by two researchers and compared in an iterative process to formulate an overarching framework on the assessment of decisional capacity. We selected 20 patients who had an advance directive and were judged to be decisionally compromised, as well as a selection of 40 EAS cases judged to be decisionally competent, half of which also had an advance directive (purposive sampling).

Results

Decisional capacity was present in every case report. Predefined, external criteria were rarely described explicitly, but physicians indirectly referred to the (cognitive) criteria set by Appelbaum and Grisso. Whether the thresholds for these dimensional criteria were met was influenced by six supporting factors (level of communication, psychiatric comorbidity, personality, presence of an advance directive, consistency of the request, and, finally, the patient–physician relationship) that also directly contributed to the judgment of capacity. The involved physicians and executed investigations were the two contextual factors providing a background.

Conclusions

Decisional capacity regarding euthanasia is a multidimensional construct, often implicitly assessed and influenced by supporting and contextual factors. The subjectivity of the final judgment poses ethical and legal issues and argues for continuous quality improvement processes.

背景:在荷兰,获准安乐死或协助自杀(EAS)的痴呆症患者人数逐年增加。根据法律规定,患者需要具备决策能力或预先指示。由于痴呆症会逐渐影响患者的认知能力,因此评估患者的决策能力具有挑战性。我们旨在定性评估哪些因素以及如何影响对痴呆症 EAS 病例决策能力的判断:我们对荷兰地区安乐死审查委员会在 2012 年至 2021 年间发布的 60 份痴呆症安乐死案例摘要进行了定性研究。我们采用基础理论方法对纳入的报告进行了评估。所有与决定能力相关的引文均由两名研究人员独立编码,并通过反复比较,最终制定出一个评估决定能力的总体框架。我们选取了 20 名有预先指示且被判定为决策能力受损的患者,并选取了 40 个被判定为有决策能力的 EAS 病例,其中一半也有预先指示(目的性抽样):结果:每份病例报告中都存在决策能力问题。预设的外部标准很少被明确描述,但医生间接提到了阿贝尔鲍姆(Appelbaum)和格里斯索(Grisso)制定的(认知)标准。是否符合这些维度标准的阈值受到六个辅助因素的影响(沟通水平、精神疾病合并症、性格、是否有预先指示、请求的一致性,以及最后的医患关系),这些因素也直接影响了对行为能力的判断。参与调查的医生和已执行的调查是两个背景因素:关于安乐死的决定能力是一个多维度的概念,通常是隐性评估,并受到支持因素和背景因素的影响。最终判断的主观性带来了伦理和法律问题,因此需要不断改进质量。
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引用次数: 0
Predictors of advance care planning in 11 high-income nations 11 个高收入国家预先护理规划的预测因素。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-17 DOI: 10.1111/jgs.19226
Preshit N. Ambade DrPH, Zachary T. Hoffman MS, Kaamya Mehra BS/MD(c), Neil J. MacKinnon PhD

Background

Elderly population is increasing in high-income countries. For instance, by 2050, 21.4% of the United States population is expected to be 65+, thus making advance care planning (ACP) increasingly important. We aim to identify predictors of ACP completion in 11 high-income countries and explore relationships between ACP and utilization factors.

Method

Using the 2021 International Health Policy (IHP) survey data, we assessed the relationship between sociodemographic factors, healthcare utilization, and ACP. The primary outcome variable was a composite of three ACP activities. A generalized linear mixed model (GLMM) was used to identify predictors of ACP completion.

Results

Analyses included 18,677 older adults who answered at least one ACP question. Only 5126 (27.4%) reported completion of three ACP activities. Germany (64.7%) showed the highest completion rates, while Sweden (5.0%) and France (5.0%) showed the lowest completion rates. Predictors of ACP completion identified in the GLMM were: increasing age (incidence rate ratio [IRR] range between 1.2 and 1.5), completion of high school education or more (IRR: 1.1, 95% CI: 1.1–1.1), higher income (IRR: 1.1, 95% CI: 1.1–1.2), presence of two or more health conditions (IRR: 1.1, 95% CI: 1.0–1.1), hospital stay in the past 2 years (IRR: 1.1, 95% CI: 1.1–1.1), and access to quality primary care (IRR: 1.0, 95% CI: 1.0–1.1). Male gender (IRR: 0.9, 95% CI: 0.8–0.9) had a negative association with ACP activity completion.

Conclusion

Several patient-specific and health system utilization factors were identified as predictors of ACP activity completion, which clinicians and policymakers could use to enhance ACP completion.

背景:在高收入国家,老年人口正在不断增加。例如,到 2050 年,美国 21.4% 的人口预计将达到 65 岁以上,这使得预先护理计划(ACP)变得越来越重要。我们旨在确定 11 个高收入国家完成 ACP 的预测因素,并探讨 ACP 与利用因素之间的关系:利用 2021 年国际卫生政策(IHP)调查数据,我们评估了社会人口因素、医疗保健利用率和 ACP 之间的关系。主要结果变量是 ACP 三项活动的综合结果。我们使用广义线性混合模型(GLMM)来确定完成 ACP 的预测因素:分析包括 18677 名至少回答了一个 ACP 问题的老年人。只有 5126 人(27.4%)报告完成了三项 ACP 活动。德国(64.7%)的完成率最高,而瑞典(5.0%)和法国(5.0%)的完成率最低。在 GLMM 中确定的完成 ACP 的预测因素有:年龄增加(发病率比 [IRR] 范围在 1.2 和 1.5 之间)、完成高中或以上教育(IRR:1.1,95% CI:1.1-1.1)、收入增加(IRR:1.1,95% CI:1.1-1.2)、有两种或两种以上健康状况(IRR:1.1,95% CI:1.0-1.1)、过去 2 年住院(IRR:1.1,95% CI:1.1-1.1)以及获得优质初级医疗服务(IRR:1.0,95% CI:1.0-1.1)。男性性别(IRR:0.9,95% CI:0.8-0.9)与完成 ACP 活动呈负相关:结论:几项患者特异性因素和医疗系统使用因素被认为是 ACP 活动完成度的预测因素,临床医生和政策制定者可以利用这些因素来提高 ACP 活动的完成度。
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引用次数: 0
A public health/hospital partnership to improve Emergency Department transitions of care for vulnerable older adults 公共卫生与医院合作,改善急诊科对弱势老年人的过渡护理。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-10-17 DOI: 10.1111/jgs.19227
Lauren T. Southerland MD, MPH, Carolyn Dixon MSSA, mSAC, LSW, Shameka Turner, Kalih M. West BSW, Tameka Hairston RN, Tony Rosen MD, MPH, Caroline Rankin MPH

Background

Community-dwelling older adults are at high risk for unmet social service needs. We describe a novel partnership embedding county services case managers in the Emergency Department (ED) to connect older adults to community services alongside their medical care.

Methods

Setting: A medium-sized urban ED with 55,000 patient visits a year. Intervention: Case managers from the Franklin County, Ohio Office on Aging (OA) were embedded within the ED. The OA team worked with the ED social work team to identify community-dwelling older patients, perform an in-person intake assessment, and initiate needed community services (including home-delivered meals, emergency response systems, house repairs, and transportation). Program logic model and development are reported in detail.

Results

From June to December 2023, there were 7284 ED visits for adults ≥60 years old. Referrals to the OA case manager ranged from 1 to 13 per day. The OA case managers performed 252 full intake assessments on unique patients. The population was 51% men. Only 11% (n = 28) were currently connected to OA services, and of those already connected 29% (n = 8) needed increased services. Of the remaining unconnected patients (n = 224), 8% (n = 20) were not county residents and the OA team connected them with other county OAs. Half 53% (n = 120) were accepting of services and had services from the OA or other community health programs initiated during the ED visit. The OA team made three new Adult Protective Services referrals and one referral to the long-term care ombudsman. The program did not increase ED length of stay or hospital admission rates.

Conclusions

Embedding county service enrollment within a community ED is a cost neutral intervention that reached a population without previous services. Future plans include expansion of the program and evaluation of the program's ability to detect elder mistreatment and self-neglect.

背景:居住在社区的老年人是社会服务需求得不到满足的高危人群。我们介绍了一种新颖的合作方式,即在急诊科(ED)中设置县级服务机构的个案经理,在为老年人提供医疗服务的同时,将他们与社区服务联系起来:环境:干预措施:干预措施:俄亥俄州富兰克林县老龄化办公室(OA)的个案经理被派驻到急诊科。OA 团队与急诊室社工团队合作,识别居住在社区的老年患者,进行上门入院评估,并启动所需的社区服务(包括送餐上门、应急响应系统、房屋维修和交通)。详细报告了计划逻辑模型和发展情况:从 2023 年 6 月到 12 月,≥60 岁的成年人共接受了 7284 次急诊室就诊。转介给 OA 个案经理的人数从每天 1 人到 13 人不等。OA 个案经理共对 252 名患者进行了全面的入院评估。其中 51% 为男性。目前只有 11%(n = 28)的患者获得了 OA 服务,而在已经获得 OA 服务的患者中,29%(n = 8)的患者需要更多服务。在其余未连接的患者(n = 224)中,8%(n = 20)不是本县居民,OA 小组将他们连接到了本县其他 OA。半数 53%(n = 120)的患者接受了服务,并在急诊室就诊期间接受了 OA 或其他社区健康计划提供的服务。OA 小组新转介了 3 名成人保护服务人员和 1 名长期护理监察员。该计划并未增加急诊室的住院时间或入院率:在社区急诊室内嵌入县级服务登记是一项成本中立的干预措施,可惠及以前未接受过服务的人群。未来的计划包括扩展该计划并评估该计划检测虐待老人和自我忽视的能力。
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Journal of the American Geriatrics Society
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