首页 > 最新文献

Journal of the American Geriatrics Society最新文献

英文 中文
Age Does Not Influence Postoperative Lactate Values in Older Adult Trauma Patients 年龄不影响老年创伤患者术后乳酸值。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-06 DOI: 10.1111/jgs.70152
Kristin Salottolo, Alexander Knippenberg, Michael Fisher, Timbre Backen, Alexandra Moody, Kaysie Banton, David Bar-Or

Background

Lactate monitoring is used to dynamically identify patients with a higher risk of poor outcomes. However, elevated lactate levels are interpreted using the same stratification regardless of patient age. Age could be a modifying factor for circulating lactate levels that has not been adequately examined. We hypothesized that there would be a negative association between age and lactate values in the geriatric population.

Methods

This retrospective observational study included patients ≥ 65 years old undergoing operative intervention between 1/1/2023 and 8/1/2023. Postoperative venous lactate (pVL) values and patients' age were examined continuously and categorically (pVL: < 2, 2–3, ≥ 3 mmol/L; age: 65–74, 75–84, ≥ 85 years). The association between pVL and age was analyzed overall and after stratifying by potential confounders: nonsurvival (morgue/hospice vs. other hospital disposition), ICU admission, injury severity (ISS ≥ 16 vs. < 16), and frailty (modified frailty index-5 ≥ 2 vs. < 2).

Results

There were 284 surgically managed older adults; the median age was 80 (73–88) years and 37% were ≥ 85 years old. Overall, 218 (77%) patients had a pVL, assessed 8 (7–11) hours postoperatively. The median pVL was 1.8 (1.3–2.5) mmol/L and 13% had pVL ≥ 3 mmol/L. Age and pVL values were not associated when examined continuously (r2 = 0.08, p = 0.20) nor categorically (p = 0.44). Age and pVL were not associated when stratified by ICU admittance (ICU: r2 = 0.17, p = 0.44; non-ICU: r2 = 0.07, p = 0.33), by ISS (≥ 16, r2 = −0.03, p = 0.92; < 16: r2 = 0.12, p = 0.09), by survival (survivors: r2 = 0.08, p = 0.23; nonsurvivors: r2 = −0.13, p = 0.64), and by frailty (frail: r2 = 0.14, p = 0.15; not frail: r2 = −0.07, p = 0.48).

Conclusions

These results suggest that age is not an important consideration or concern when interpreting postoperative lactate values of older adult trauma patients.

背景:乳酸监测用于动态识别预后不良风险较高的患者。然而,无论患者年龄如何,升高的乳酸水平都可以用相同的分层来解释。年龄可能是循环乳酸水平的一个修改因素,但尚未得到充分的研究。我们假设在老年人群中,年龄和乳酸值之间存在负相关。方法:本回顾性观察研究纳入2023年1月1日至2023年8月1日期间接受手术干预的≥65岁患者。连续分类检测术后静脉乳酸(pVL)值和患者年龄(pVL:结果:284例手术处理的老年人,中位年龄为80(73-88)岁,37%年龄≥85岁。总体而言,218例(77%)患者术后8(7-11)小时出现pVL。中位pVL为1.8 (1.3-2.5)mmol/L, 13%的患者pVL≥3mmol /L。当连续检查时,年龄和pVL值没有相关性(r2 = 0.08, p = 0.20),也没有分类相关性(p = 0.44)。按ICU入院(ICU: r2 = 0.17, p = 0.44;非ICU: r2 = 0.07, p = 0.33)、ISS(≥16,r2 = -0.03, p = 0.92; 2 = 0.12, p = 0.09)、生存率(幸存者:r2 = 0.08, p = 0.23;非幸存者:r2 = -0.13, p = 0.64)和虚弱程度(虚弱:r2 = 0.14, p = 0.15;不虚弱:r2 = -0.07, p = 0.48)分层,年龄和pVL无相关性。结论:这些结果表明,在解释老年创伤患者术后乳酸值时,年龄不是一个重要的考虑因素或关注点。
{"title":"Age Does Not Influence Postoperative Lactate Values in Older Adult Trauma Patients","authors":"Kristin Salottolo,&nbsp;Alexander Knippenberg,&nbsp;Michael Fisher,&nbsp;Timbre Backen,&nbsp;Alexandra Moody,&nbsp;Kaysie Banton,&nbsp;David Bar-Or","doi":"10.1111/jgs.70152","DOIUrl":"10.1111/jgs.70152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Lactate monitoring is used to dynamically identify patients with a higher risk of poor outcomes. However, elevated lactate levels are interpreted using the same stratification regardless of patient age. Age could be a modifying factor for circulating lactate levels that has not been adequately examined. We hypothesized that there would be a negative association between age and lactate values in the geriatric population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective observational study included patients ≥ 65 years old undergoing operative intervention between 1/1/2023 and 8/1/2023. Postoperative venous lactate (pVL) values and patients' age were examined continuously and categorically (pVL: &lt; 2, 2–3, ≥ 3 mmol/L; age: 65–74, 75–84, ≥ 85 years). The association between pVL and age was analyzed overall and after stratifying by potential confounders: nonsurvival (morgue/hospice vs. other hospital disposition), ICU admission, injury severity (ISS ≥ 16 vs. &lt; 16), and frailty (modified frailty index-5 ≥ 2 vs. &lt; 2).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 284 surgically managed older adults; the median age was 80 (73–88) years and 37% were ≥ 85 years old. Overall, 218 (77%) patients had a pVL, assessed 8 (7–11) hours postoperatively. The median pVL was 1.8 (1.3–2.5) mmol/L and 13% had pVL ≥ 3 mmol/L. Age and pVL values were not associated when examined continuously (<i>r</i><sup>2</sup> = 0.08, <i>p</i> = 0.20) nor categorically (<i>p</i> = 0.44). Age and pVL were not associated when stratified by ICU admittance (ICU: <i>r</i><sup>2</sup> = 0.17, <i>p</i> = 0.44; non-ICU: <i>r</i><sup>2</sup> = 0.07, <i>p</i> = 0.33), by ISS (≥ 16, <i>r</i><sup>2</sup> = −0.03, <i>p</i> = 0.92; &lt; 16: <i>r</i><sup>2</sup> = 0.12, <i>p</i> = 0.09), by survival (survivors: <i>r</i><sup>2</sup> = 0.08, <i>p</i> = 0.23; nonsurvivors: <i>r</i><sup>2</sup> = −0.13, <i>p</i> = 0.64), and by frailty (frail: <i>r</i><sup>2</sup> = 0.14, <i>p</i> = 0.15; not frail: <i>r</i><sup>2</sup> = −0.07, <i>p</i> = 0.48).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results suggest that age is not an important consideration or concern when interpreting postoperative lactate values of older adult trauma patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 2","pages":"488-492"},"PeriodicalIF":4.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Street Where You Live 在你住的街上。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-06 DOI: 10.1111/jgs.70140
Karen Bensinger
{"title":"On the Street Where You Live","authors":"Karen Bensinger","doi":"10.1111/jgs.70140","DOIUrl":"10.1111/jgs.70140","url":null,"abstract":"","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 11","pages":"3586-3587"},"PeriodicalIF":4.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Mindfulness Training on Depression and Cognition in Older People With Mild Cognitive Impairment: A Systematic Review and Meta-Analysis 正念训练对轻度认知障碍老年人抑郁和认知的影响:系统回顾和荟萃分析。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-06 DOI: 10.1111/jgs.70154
Edgar Vásquez-Carrasco, Braulio Henrique Magnani Branco, Jordan Hernandez-Martinez, Cristian Sandoval, Pablo Valdés-Badilla

Background

This systematic review and meta-analysis aimed to evaluate the efficacy of mindfulness-based treatments for older people with mild cognitive impairment (MCI) who also experience depression and cognitive difficulties.

Methods

Seven databases were searched: PubMed, EBSCOhost, CINAHL Complete, Cochrane Library, ProQuest, Scopus, and Web of Science, up to July 2025. PRISMA guidelines, the Oxford Centre for Evidence-Based Medicine scale, the RoB 2 tool, and GRADEpro were employed to evaluate the methodological quality and evidence reliability. The review plan was pre-registered in the PROSPERO database (CRD420251080874).

Results

Initially, 1738 records were identified in the databases. Thirteen studies that met the inclusion criteria were included in the analysis. The PICOS framework was employed for the subsequent analysis. The meta-analysis indicated that participants receiving mindfulness therapies experienced a significant reduction in depression symptoms, as assessed by the Geriatric Depression Scale (GDS, p = 0.045). In contrast, the Montreal Cognitive Assessment (p = 0.061) and the Mini-Mental State Examination (p = 0.713) did not demonstrate statistically significant changes in cognitive ability.

Conclusions

The findings suggest that mindfulness-based training may reduce depressive symptoms in older individuals with MCI; however, the impact on cognitive abilities remains inconclusive.

背景:本系统综述和荟萃分析旨在评估以正念为基础的治疗对患有轻度认知障碍(MCI)且患有抑郁症和认知困难的老年人的疗效。方法:检索截至2025年7月的PubMed、EBSCOhost、CINAHL Complete、Cochrane Library、ProQuest、Scopus、Web of Science等7个数据库。采用PRISMA指南、牛津循证医学中心量表、RoB 2工具和GRADEpro来评估方法学质量和证据可靠性。评审计划在PROSPERO数据库中预注册(CRD420251080874)。结果:最初,在数据库中确定了1738条记录。13项符合纳入标准的研究被纳入分析。随后的分析采用PICOS框架。荟萃分析表明,接受正念疗法的参与者抑郁症状显著减轻,通过老年抑郁量表(GDS, p = 0.045)进行评估。相比之下,蒙特利尔认知评估(p = 0.061)和迷你精神状态检查(p = 0.713)没有显示认知能力有统计学意义的变化。结论:研究结果表明,正念训练可以减轻老年轻度认知障碍患者的抑郁症状;然而,对认知能力的影响仍然没有定论。
{"title":"Effects of Mindfulness Training on Depression and Cognition in Older People With Mild Cognitive Impairment: A Systematic Review and Meta-Analysis","authors":"Edgar Vásquez-Carrasco,&nbsp;Braulio Henrique Magnani Branco,&nbsp;Jordan Hernandez-Martinez,&nbsp;Cristian Sandoval,&nbsp;Pablo Valdés-Badilla","doi":"10.1111/jgs.70154","DOIUrl":"10.1111/jgs.70154","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This systematic review and meta-analysis aimed to evaluate the efficacy of mindfulness-based treatments for older people with mild cognitive impairment (MCI) who also experience depression and cognitive difficulties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven databases were searched: PubMed, EBSCOhost, CINAHL Complete, Cochrane Library, ProQuest, Scopus, and Web of Science, up to July 2025. PRISMA guidelines, the Oxford Centre for Evidence-Based Medicine scale, the RoB 2 tool, and GRADEpro were employed to evaluate the methodological quality and evidence reliability. The review plan was pre-registered in the PROSPERO database (CRD420251080874).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Initially, 1738 records were identified in the databases. Thirteen studies that met the inclusion criteria were included in the analysis. The PICOS framework was employed for the subsequent analysis. The meta-analysis indicated that participants receiving mindfulness therapies experienced a significant reduction in depression symptoms, as assessed by the Geriatric Depression Scale (GDS, <i>p</i> = 0.045). In contrast, the Montreal Cognitive Assessment (<i>p</i> = 0.061) and the Mini-Mental State Examination (<i>p</i> = 0.713) did not demonstrate statistically significant changes in cognitive ability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings suggest that mindfulness-based training may reduce depressive symptoms in older individuals with MCI; however, the impact on cognitive abilities remains inconclusive.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 2","pages":"566-574"},"PeriodicalIF":4.5,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145240656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Glycemic Risk Assessment in Long-Term Care: Suggestions for Future Research 加强长期护理中血糖风险评估:对未来研究的建议。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70124
Zhen Xu, Fan Zhang, Huachun Zhang
<p>We read with great interest the study by Wondimkun et al., which leveraged the Registry of Senior Australians to quantify 12-month hospitalizations for acute glycemic events after entry to long-term care facilities (LTCFs) [<span>1</span>]. While the authors should be commended for analyzing a national cohort of ≥ 55,000 residents, we believe three methodological issues merit attention to maximize the translational value of their findings.</p><p>First, the true incidence may be higher than reported. When the analysis relied only on principal public-hospital diagnosis codes, 12-month rates were 1.0% for hypoglycemia and 0.5% for hyperglycemia; adding secondary codes tripled these figures, and private-hospital data were not available. Moreover, many acute glycemic events may be misclassified at presentation—as falls, near syncope, stroke, myocardial infarction, or altered mental status—which can further obscure detection and understate the true burden. Linking emergency-department and private-hospital records or using glucose logs kept by nursing staff in LTCFs could capture events that never reach a public-hospital discharge sheet.</p><p>Second, key markers of glycemic control are missing. HbA1c, glucose variability, and insulin dose—all powerful predictors of both hypo- and hyperglycemia in frail older adults—are not captured in ROSA [<span>2</span>], even though the 2024 ADA Standards of Care for Older Adults explicitly recommend tailoring therapeutic targets on the basis of HbA1c and day-to-day glucose swings [<span>3</span>]. Linking ROSA to central laboratory feeds or point-of-care testing systems inside LTCFs would make it possible to run HbA1c-stratified analyses and produce more accurate medication-safety estimates.</p><p>Third, generalizability and equity deserve attention. Aboriginal and Torres Strait Islander residents were excluded, and residents whose preferred language was not English faced a higher hyperglycemia risk in the study; language barriers are known to impair diabetes control and cardiovascular risk-factor management [<span>4</span>]. Including Indigenous Australians and adding culture-specific variables would broaden applicability and help tailor prevention programmers for communities carrying a disproportionate diabetes burden.</p><p>In conclusion, Wondimkun et al. provide a valuable snapshot of glycemic emergencies in Australian LTCFs. Addressing event capture, adding laboratory data, and broadening the sample would make the work even more useful for policymakers and bedside teams alike.</p><p>Z.X. conceived the idea for the commentary, performed the literature review, and drafted the manuscript. H.Z. and F.Z. revised the manuscript critically for important intellectual content, approved the final version, and are accountable for all aspects of the work.</p><p>The authors have nothing to report.</p><p>The authors declare no conflicts of interest.</p><p>This publication is linked to a related article by Wondimkun et al
我们非常感兴趣地阅读了Wondimkun等人的研究,该研究利用澳大利亚老年人登记处量化了进入长期护理机构(ltcf) bbb后12个月的急性血糖事件住院情况。虽然作者分析了≥55,000名居民的国家队列应该受到赞扬,但我们认为有三个方法学问题值得注意,以最大限度地提高其研究结果的转化价值。首先,真实的发病率可能比报道的要高。当分析仅依赖于主要公立医院的诊断代码时,12个月低血糖率为1.0%,高血糖率为0.5%;加上二级代码,这些数字增加了两倍,而且私立医院的数据无法获得。此外,许多急性血糖事件可能在表现时被错误分类,如跌倒、近晕厥、中风、心肌梗死或精神状态改变,这可能进一步模糊检测和低估真正的负担。将急诊科和私立医院的记录联系起来,或者使用ltcf中护理人员保存的血糖记录,可以捕捉到公立医院出院表中从未出现过的事件。其次,血糖控制的关键指标缺失。HbA1c、葡萄糖可变性和胰岛素剂量——这些都是体弱老年人低血糖和高血糖的有力预测指标——在ROSA[2]中没有被纳入,尽管2024年ADA老年人护理标准明确建议根据HbA1c和日常血糖波动[3]定制治疗靶点。将ROSA与ltcf内的中心实验室饲料或护理点检测系统连接起来,将使hba1c分层分析成为可能,并产生更准确的药物安全性估计。第三,概括性和公平性值得关注。原住民和托雷斯海峡岛民被排除在外,首选语言不是英语的居民在研究中面临更高的高血糖风险;众所周知,语言障碍会损害糖尿病控制和心血管危险因素管理[10]。包括澳大利亚土著居民和增加文化特定变量将扩大适用性,并有助于为承担不成比例的糖尿病负担的社区量身定制预防方案。综上所述,Wondimkun等人提供了澳大利亚ltcf中血糖紧急情况的有价值的快照。解决事件捕获、增加实验室数据和扩大样本将使这项工作对政策制定者和像z.x这样的床边团队更有用。构思评论的想法,进行文献综述,并起草手稿。华正和华正对重要的知识内容进行了严格的修改,批准了最终版本,并对工作的各个方面负责。作者没有什么可报告的。作者声明无利益冲突。本出版物链接到Wondimkun等人的相关文章。要查看本文,请访问https://doi.org/10.1111/jgs.70131。
{"title":"Enhancing Glycemic Risk Assessment in Long-Term Care: Suggestions for Future Research","authors":"Zhen Xu,&nbsp;Fan Zhang,&nbsp;Huachun Zhang","doi":"10.1111/jgs.70124","DOIUrl":"10.1111/jgs.70124","url":null,"abstract":"&lt;p&gt;We read with great interest the study by Wondimkun et al., which leveraged the Registry of Senior Australians to quantify 12-month hospitalizations for acute glycemic events after entry to long-term care facilities (LTCFs) [&lt;span&gt;1&lt;/span&gt;]. While the authors should be commended for analyzing a national cohort of ≥ 55,000 residents, we believe three methodological issues merit attention to maximize the translational value of their findings.&lt;/p&gt;&lt;p&gt;First, the true incidence may be higher than reported. When the analysis relied only on principal public-hospital diagnosis codes, 12-month rates were 1.0% for hypoglycemia and 0.5% for hyperglycemia; adding secondary codes tripled these figures, and private-hospital data were not available. Moreover, many acute glycemic events may be misclassified at presentation—as falls, near syncope, stroke, myocardial infarction, or altered mental status—which can further obscure detection and understate the true burden. Linking emergency-department and private-hospital records or using glucose logs kept by nursing staff in LTCFs could capture events that never reach a public-hospital discharge sheet.&lt;/p&gt;&lt;p&gt;Second, key markers of glycemic control are missing. HbA1c, glucose variability, and insulin dose—all powerful predictors of both hypo- and hyperglycemia in frail older adults—are not captured in ROSA [&lt;span&gt;2&lt;/span&gt;], even though the 2024 ADA Standards of Care for Older Adults explicitly recommend tailoring therapeutic targets on the basis of HbA1c and day-to-day glucose swings [&lt;span&gt;3&lt;/span&gt;]. Linking ROSA to central laboratory feeds or point-of-care testing systems inside LTCFs would make it possible to run HbA1c-stratified analyses and produce more accurate medication-safety estimates.&lt;/p&gt;&lt;p&gt;Third, generalizability and equity deserve attention. Aboriginal and Torres Strait Islander residents were excluded, and residents whose preferred language was not English faced a higher hyperglycemia risk in the study; language barriers are known to impair diabetes control and cardiovascular risk-factor management [&lt;span&gt;4&lt;/span&gt;]. Including Indigenous Australians and adding culture-specific variables would broaden applicability and help tailor prevention programmers for communities carrying a disproportionate diabetes burden.&lt;/p&gt;&lt;p&gt;In conclusion, Wondimkun et al. provide a valuable snapshot of glycemic emergencies in Australian LTCFs. Addressing event capture, adding laboratory data, and broadening the sample would make the work even more useful for policymakers and bedside teams alike.&lt;/p&gt;&lt;p&gt;Z.X. conceived the idea for the commentary, performed the literature review, and drafted the manuscript. H.Z. and F.Z. revised the manuscript critically for important intellectual content, approved the final version, and are accountable for all aspects of the work.&lt;/p&gt;&lt;p&gt;The authors have nothing to report.&lt;/p&gt;&lt;p&gt;The authors declare no conflicts of interest.&lt;/p&gt;&lt;p&gt;This publication is linked to a related article by Wondimkun et al","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 1","pages":"282-283"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Barriers and Facilitators to the Fidelity of Delirium Screening in the Emergency Department: An Ethnographic Approach 障碍和促进谵妄筛查的保真度在急诊科:民族志方法。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70142
Kayla P. Carpenter, Fernanda Bellolio, Manuela Bartolacci, Molly M. Jeffery, Susan M. Bower, Lauren T. Southerland, Aidan F. Mullan, Jennifer L. Ridgeway

Background

The Geriatric Emergency Department (ED) guidelines recommend screening older adults for delirium using evidence-based screening tools, but these tools are often underutilized. We aimed to identify barriers and facilitators to implementing an electronic health record (EHR)-based delirium screening tool as intended.

Methods

This mixed methods and focused ethnographic study combined a review of structured delirium screening data with observations of real-time delirium screenings and semi-structured in-person interviews at an academic ED that previously implemented the Delirium Triage Screen (DTS) and Brief Confusion Assessment Method (bCAM) tool. Content analysis of field notes from observations and interview transcripts was guided by the Exploration, Preparation, Implementation, and Sustainment implementation framework.

Results

From a total of 40,818 ED visits, 6196 (15.2%) had incomplete screens (i.e., without fidelity). We observed 62 encounters, of which 25 (40.3%) screenings were implemented without fidelity due to (1) not asking the required screening questions, (2) assuming patient responses, or (3) not completing the screen due to uncertainty regarding a patient's baseline mentation. We conducted 32 interviews. Identified barriers included staff prioritization of other tasks (e.g., stroke code, cleaning patients), limited knowledge of the screen's importance and utility, and language discordance. Facilitators included care partners providing baseline mental status information and nurses prefacing the screening to increase patient engagement.

Conclusion

The fidelity of ED delirium screening is influenced by an interplay of environmental, patient, provider, and caregiver factors. Fidelity may be improved by focusing education on the importance of screening, training screeners on how to determine whether a patient's mentation is acutely changed, providing clear action steps when a patient screens positive, and addressing how to administer the delirium screen to patients who do not speak English fluently.

背景:老年急诊科(ED)指南推荐使用循证筛查工具筛查老年人谵妄,但这些工具往往未得到充分利用。我们的目的是确定障碍和促进实施电子健康记录(EHR)为基础的谵妄筛查工具的预期。方法:这项混合方法和重点人种学研究结合了对结构化谵妄筛查数据的回顾,以及对实时谵妄筛查和半结构化面对面访谈的观察,该学术ED先前实施了谵妄分诊筛查(DTS)和简短混乱评估方法(bCAM)工具。根据探索、准备、实施和维持实施框架,对来自观察和访谈笔录的实地记录进行内容分析。结果:在40,818例ED就诊中,6196例(15.2%)筛查不完整(即无保真度)。我们观察到62次接触,其中25次(40.3%)筛查的实施没有保真度,原因是(1)没有询问所需的筛查问题,(2)假设患者的反应,或(3)由于不确定患者的基线心理状态而没有完成筛查。我们进行了32次访谈。确定的障碍包括工作人员对其他任务的优先级(例如,中风代码,清洁患者),对屏幕重要性和效用的了解有限,以及语言不一致。辅助人员包括提供基线精神状态信息的护理伙伴和负责筛查的护士,以提高患者的参与度。结论:ED谵妄筛查的保真度受环境、患者、提供者和照顾者因素的相互作用影响。通过关注筛查重要性的教育,培训筛查人员如何确定患者的精神状态是否发生了剧烈变化,当患者筛查呈阳性时提供明确的行动步骤,以及解决如何对英语不流利的患者进行谵妄筛查,可以提高准确性。
{"title":"Barriers and Facilitators to the Fidelity of Delirium Screening in the Emergency Department: An Ethnographic Approach","authors":"Kayla P. Carpenter,&nbsp;Fernanda Bellolio,&nbsp;Manuela Bartolacci,&nbsp;Molly M. Jeffery,&nbsp;Susan M. Bower,&nbsp;Lauren T. Southerland,&nbsp;Aidan F. Mullan,&nbsp;Jennifer L. Ridgeway","doi":"10.1111/jgs.70142","DOIUrl":"10.1111/jgs.70142","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Geriatric Emergency Department (ED) guidelines recommend screening older adults for delirium using evidence-based screening tools, but these tools are often underutilized. We aimed to identify barriers and facilitators to implementing an electronic health record (EHR)-based delirium screening tool as intended.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This mixed methods and focused ethnographic study combined a review of structured delirium screening data with observations of real-time delirium screenings and semi-structured in-person interviews at an academic ED that previously implemented the Delirium Triage Screen (DTS) and Brief Confusion Assessment Method (bCAM) tool. Content analysis of field notes from observations and interview transcripts was guided by the Exploration, Preparation, Implementation, and Sustainment implementation framework.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From a total of 40,818 ED visits, 6196 (15.2%) had incomplete screens (i.e., without fidelity). We observed 62 encounters, of which 25 (40.3%) screenings were implemented without fidelity due to (1) not asking the required screening questions, (2) assuming patient responses, or (3) not completing the screen due to uncertainty regarding a patient's baseline mentation. We conducted 32 interviews. Identified barriers included staff prioritization of other tasks (e.g., stroke code, cleaning patients), limited knowledge of the screen's importance and utility, and language discordance. Facilitators included care partners providing baseline mental status information and nurses prefacing the screening to increase patient engagement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The fidelity of ED delirium screening is influenced by an interplay of environmental, patient, provider, and caregiver factors. Fidelity may be improved by focusing education on the importance of screening, training screeners on how to determine whether a patient's mentation is acutely changed, providing clear action steps when a patient screens positive, and addressing how to administer the delirium screen to patients who do not speak English fluently.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 1","pages":"43-54"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of a Telephonic Aging Brain Care Model for Medicaid Home and Community Services for Dementia Patients and Their Caregivers 老年痴呆症患者及其照顾者的医疗补助家庭和社区服务电话脑护理模式的有效性。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70146
Malaz A. Boustani, Steven R. Counsell, Anthony Perkins, Abdelfattah Alhader, Kathryn I. Frank, Diana P. Summanwar, Karen L. Fortuna

Objectives

The primary purpose of the present study was the implementation and evaluation of the ABC Community program, a community-based and telephonically administered version of the Aging Brain Care model delivered by Area Agencies on Aging (AAAs) staff.

Design

This study employed a prospective pre-post implementation design with pre-specified effectiveness and fidelity goals, with the main outcome measure being the total score of the Health Aging Brain Care (HABC) Monitor at 3- and 6-month follow-up. The HABC Monitor has demonstrated excellent reliability and validity in monitoring and measuring the burden of dementia symptoms and the quality of life and stress of the informal caregivers.

Results

The program served 422 Medicaid Home and Community-Based Services participants living with dementia and their caregivers. Participants' mean age was 78 years, with 67% identifying as female and 30% as belonging to minority groups, including 6% Hispanic or Latino and 28% Black or African American. In comparison to baseline, the total score of the HABC Monitor decreased from 24.6 to 15.4 at 6 months, representing a 37% reduction with an effect size of 0.64 standard deviation (p value < 0.001). Approximately 46% of informal caregivers who had at least mild burden at baseline had no such burden at 6 months, and 92% of those who had no stress at baseline remained burden-free at 6 months.

Conclusion

The ABC community program might be a scalable collaborative dementia care model targeting socially vulnerable people living with dementia.

目的:本研究的主要目的是ABC社区项目的实施和评估,这是一个由地区老龄化机构(AAAs)工作人员提供的基于社区和电话管理的老年脑保健模式。设计:本研究采用前瞻性实施前-实施后设计,具有预先指定的有效性和保真度目标,主要结果测量为健康老龄化脑保健(HABC)监测在3个月和6个月随访时的总分。HABC监测仪在监测和衡量非正式照顾者的痴呆症状负担、生活质量和压力方面显示出极高的可靠性和有效性。结果:该项目为422名患有痴呆症的家庭和社区医疗补助服务参与者及其护理人员提供了服务。参与者的平均年龄为78岁,67%为女性,30%属于少数群体,其中6%为西班牙裔或拉丁裔,28%为黑人或非裔美国人。与基线相比,HABC监测的总得分在6个月时从24.6下降到15.4,减少了37%,效应值为0.64标准差(p值)。结论:ABC社区项目可能是一种可扩展的针对社会弱势痴呆症患者的协同痴呆症护理模式。
{"title":"Effectiveness of a Telephonic Aging Brain Care Model for Medicaid Home and Community Services for Dementia Patients and Their Caregivers","authors":"Malaz A. Boustani,&nbsp;Steven R. Counsell,&nbsp;Anthony Perkins,&nbsp;Abdelfattah Alhader,&nbsp;Kathryn I. Frank,&nbsp;Diana P. Summanwar,&nbsp;Karen L. Fortuna","doi":"10.1111/jgs.70146","DOIUrl":"10.1111/jgs.70146","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The primary purpose of the present study was the implementation and evaluation of the ABC Community program, a community-based and telephonically administered version of the Aging Brain Care model delivered by Area Agencies on Aging (AAAs) staff.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>This study employed a prospective pre-post implementation design with pre-specified effectiveness and fidelity goals, with the main outcome measure being the total score of the Health Aging Brain Care (HABC) Monitor at 3- and 6-month follow-up. The HABC Monitor has demonstrated excellent reliability and validity in monitoring and measuring the burden of dementia symptoms and the quality of life and stress of the informal caregivers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The program served 422 Medicaid Home and Community-Based Services participants living with dementia and their caregivers. Participants' mean age was 78 years, with 67% identifying as female and 30% as belonging to minority groups, including 6% Hispanic or Latino and 28% Black or African American. In comparison to baseline, the total score of the HABC Monitor decreased from 24.6 to 15.4 at 6 months, representing a 37% reduction with an effect size of 0.64 standard deviation (<i>p</i> value &lt; 0.001). Approximately 46% of informal caregivers who had at least mild burden at baseline had no such burden at 6 months, and 92% of those who had no stress at baseline remained burden-free at 6 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The ABC community program might be a scalable collaborative dementia care model targeting socially vulnerable people living with dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 2","pages":"547-554"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12911546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Qualitative Study of Health Priorities of People With Dementia and Care Partners in Emergency Department and Hospital Care in a Public Safety-Net Setting 公共安全网环境下急诊科和医院护理中痴呆患者及其护理伙伴健康优先级的定性研究
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70136
Anita Chary, Sumin Yoon, Victor Lara, Annika Bhananker, Michelle Suh, Kei Ouchi, Maura Kennedy, Aanand D. Naik

Background

Over half of the people with dementia visit the emergency department (ED) each year. Little is known about how people with dementia and their care partners conceptualize or communicate about health outcome goals or care preferences during acute care episodes.

Participants and Setting

We conducted interviews with 14 Hispanic people with dementia and 19 care partners recruited from a public safety net hospital system in the southeastern United States. Participants were community-dwelling and had recently visited the ED.

Methods

We used a qualitative study design informed by phenomenology and guided by the patient priorities care (PPC) framework. Interviews elicited patients' health priorities, including their care preferences and health outcome goals, as well as their experiences communicating with ED and hospital care teams. We used a deductive content analysis to identify health priorities and inductive thematic analysis regarding communication experiences.

Results

We identified three key themes. First, participants' health priorities were grounded in values of maintaining social connection and independence. Second, hospitalizations were distressing, disorienting, and physically burdensome for both patients and care partners, leading to preferences to avoid admission whenever possible. Third, communication with ED and hospital teams felt unidirectional, with care plans delivered rather than discussed. Participants felt that care preferences were rarely elicited or incorporated into clinical decision-making.

Conclusions

Hospital admission is a critical decision point during acute care episodes for people with dementia. Incorporating brief conversations about health priorities at this juncture may improve alignment between emergency care and what matters most to patients and care partners. Adapting existing frameworks like PPC for time-pressured acute care settings may help promote shared decision-making about hospital admission.

背景:每年有超过一半的痴呆症患者到急诊科就诊。对于痴呆症患者及其护理伙伴在急性护理发作期间如何概念化或沟通健康结果目标或护理偏好,我们知之甚少。参与者和环境:我们采访了14名西班牙裔痴呆症患者和19名从美国东南部公共安全网医院系统招募的护理伙伴。参与者是社区居民,最近访问ed .方法:我们采用了一种定性研究设计,以现象学为依据,并以患者优先护理(PPC)框架为指导。访谈引出了患者的健康优先事项,包括他们的护理偏好和健康结果目标,以及他们与急诊科和医院护理团队沟通的经验。我们使用演绎内容分析来确定健康优先事项,并对交流经验进行归纳主题分析。结果:我们确定了三个关键主题。首先,参与者的健康优先事项以保持社会联系和独立的价值观为基础。其次,住院对患者和护理伙伴来说都是痛苦的、迷失方向的和身体上的负担,导致他们倾向于尽可能避免住院。第三,与急诊科和医院团队的沟通感觉是单向的,只提供护理计划,而不讨论。参与者感到护理偏好很少被引出或纳入临床决策。结论:住院是痴呆患者急性期护理的关键决策点。在这个关键时刻纳入关于卫生优先事项的简短对话,可能会改善急诊护理与对患者和护理伙伴最重要的事项之间的一致性。调整现有框架,如PPC,以适应时间紧迫的急症护理环境,可能有助于促进关于住院的共同决策。
{"title":"A Qualitative Study of Health Priorities of People With Dementia and Care Partners in Emergency Department and Hospital Care in a Public Safety-Net Setting","authors":"Anita Chary,&nbsp;Sumin Yoon,&nbsp;Victor Lara,&nbsp;Annika Bhananker,&nbsp;Michelle Suh,&nbsp;Kei Ouchi,&nbsp;Maura Kennedy,&nbsp;Aanand D. Naik","doi":"10.1111/jgs.70136","DOIUrl":"10.1111/jgs.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Over half of the people with dementia visit the emergency department (ED) each year. Little is known about how people with dementia and their care partners conceptualize or communicate about health outcome goals or care preferences during acute care episodes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Participants and Setting</h3>\u0000 \u0000 <p>We conducted interviews with 14 Hispanic people with dementia and 19 care partners recruited from a public safety net hospital system in the southeastern United States. Participants were community-dwelling and had recently visited the ED.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We used a qualitative study design informed by phenomenology and guided by the patient priorities care (PPC) framework. Interviews elicited patients' health priorities, including their care preferences and health outcome goals, as well as their experiences communicating with ED and hospital care teams. We used a deductive content analysis to identify health priorities and inductive thematic analysis regarding communication experiences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified three key themes. First, participants' health priorities were grounded in values of maintaining social connection and independence. Second, hospitalizations were distressing, disorienting, and physically burdensome for both patients and care partners, leading to preferences to avoid admission whenever possible. Third, communication with ED and hospital teams felt unidirectional, with care plans delivered rather than discussed. Participants felt that care preferences were rarely elicited or incorporated into clinical decision-making.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Hospital admission is a critical decision point during acute care episodes for people with dementia. Incorporating brief conversations about health priorities at this juncture may improve alignment between emergency care and what matters most to patients and care partners. Adapting existing frameworks like PPC for time-pressured acute care settings may help promote shared decision-making about hospital admission.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3719-3728"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men 评论:CT肌肉面积和密度与老年男性各解剖区域功能预后和死亡率的关系。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70133
Li Feng Tan, Xizhen Low, Frederick H. Koh
<p>We read with great interest the article by Hetherington-Rauth et al., which highlights the prognostic utility of automated CT-derived muscle area and density across anatomical regions in older men [<span>1</span>]. The findings underscore the value of automated opportunistic imaging for assessing sarcopenia and mortality risk in aging populations [<span>2</span>].</p><p>We commend the study's analysis and emphasis on functional outcomes, including grip strength, leg power, and walking speed. Nonetheless, the interpretation of results may benefit from a more thorough consideration of age as a potential residual confounder. Older participants naturally face a higher 10-year mortality risk. While age was included as a covariate, muscle size and density are strongly inversely correlated with age. Without accounting for age through matching or stratification, especially with the benefit of having a large cohort, the observed association between muscle metrics and mortality may be confounded by age.</p><p>Propensity score matching or age-stratified subgroup analyses could have further strengthened causal inference and minimized residual confounding. This is especially pertinent since the survival analyses showed consistent associations across regions—but without deeper exploration of whether these held across narrower age bands. It remains unclear whether poorer muscle metrics are independently predictive of mortality or simply reflect age-related risk of mortality.</p><p>From the health economic angle, where the cost of healthcare consumption is a pertinent marker of health in a given population, the authors could also consider analyzing, by decade bands of age, the association of muscle size and density with 1-year mortality, hospital attendance, or mean sick days, which would allow readers to better appreciate the impact of muscle size and quality on shorter term health-related outcomes. These parameters, with the strength of sample size, would allow more emphasis on muscle health in health promotion policies.</p><p>It was good of the authors to highlight differences with previous studies. The contrary findings regarding the association between muscle density and leg power in Korean older adults [<span>3</span>] compared with the MrOS study participants highlight important ethnic and regional differences in the assessment, cut-offs, and variations in muscle strength, density, and intermuscular adipose tissue (IMAT) in different populations. Validation in diverse populations, especially older women and multi-ethnic Asian cohorts, is crucial for generalizability.</p><p>It would have been interesting for the authors to consider and highlight the associations between muscle mass, muscle function, muscle quality, and health-related outcomes [<span>4</span>]. With increasing emphasis on muscle quality as a measurement metric for muscle health [<span>5, 6</span>], future studies pertaining to muscle health should be encouraged to assess and present thes
我们怀着极大的兴趣阅读了hetherington - rath等人的文章,该文章强调了自动ct获得的老年男性肌肉面积和跨解剖区域密度的预后效用。研究结果强调了自动机会成像在评估老年人群肌肉减少症和死亡风险方面的价值[10]。我们赞扬该研究的分析和对功能结果的强调,包括握力、腿部力量和步行速度。尽管如此,对结果的解释可能受益于更彻底地考虑年龄作为潜在的残留混杂因素。年龄较大的参与者自然面临更高的10年死亡风险。虽然年龄是一个协变量,但肌肉大小和密度与年龄呈强烈的负相关。如果没有通过匹配或分层来考虑年龄,特别是考虑到有一个大队列的好处,观察到的肌肉指标和死亡率之间的关联可能会因年龄而混淆。倾向评分匹配或年龄分层亚组分析可以进一步加强因果推理和最小化残留混淆。这是特别相关的,因为生存分析显示了跨地区的一致关联,但没有深入探索这些是否适用于更窄的年龄范围。目前尚不清楚较差的肌肉指标是独立预测死亡率还是仅仅反映与年龄相关的死亡率风险。从健康经济学的角度来看,医疗保健消费成本是特定人群健康状况的相关标志,作者还可以考虑按年龄的十年来分析肌肉大小和密度与1年死亡率、住院率或平均病假的关系,这将使读者更好地了解肌肉大小和质量对短期健康相关结果的影响。随着样本量的增加,这些参数将使健康促进政策更加重视肌肉健康。作者很好地强调了与以往研究的差异。与mri研究参与者相比,韩国老年人肌肉密度和腿部力量之间的关系的相反发现突出了不同人群在肌肉力量、密度和肌间脂肪组织(IMAT)的评估、截止值和变化方面的重要种族和地区差异。在不同人群中进行验证,特别是老年妇女和多种族亚洲人群,对于普遍性至关重要。对于作者来说,考虑和强调肌肉质量、肌肉功能、肌肉质量和健康相关结果之间的联系是很有趣的。随着越来越多的人强调肌肉质量是肌肉健康的测量指标[5,6],应该鼓励与肌肉健康有关的未来研究评估和呈现肌肉健康的这些组成部分,让读者全面了解这种日益被认可的健康状态的复杂性,这意味着无数的疾病。虽然对肌肉质量的评估方式仍然存在争议,但在文献中有更多的报道将允许进行回顾性评估,以帮助该领域的研究人员确定哪种方法的准确性最高。尽管如此,这项研究通过证明利用CT扫描进行的机会性自动评估可以产生与临床相关的肌肉健康见解,做出了有价值的贡献。将自动分割整合到放射学工作流程中,有望更早地识别肌肉减少症,但需要进一步的工作来确保这些关联在性别、种族和年龄层之间是稳健的。李峰谭和Frederick H. Koh构思并撰写了最初的手稿。所有作者都对原稿进行了修改和编辑。这份手稿没有赞助者。作者声明无利益冲突。本出版物与Megan hetherington - rath等人的相关信件相关联。要查看本文,请访问https://doi.org/10.1111/jgs.70129。
{"title":"Comment on: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men","authors":"Li Feng Tan,&nbsp;Xizhen Low,&nbsp;Frederick H. Koh","doi":"10.1111/jgs.70133","DOIUrl":"10.1111/jgs.70133","url":null,"abstract":"&lt;p&gt;We read with great interest the article by Hetherington-Rauth et al., which highlights the prognostic utility of automated CT-derived muscle area and density across anatomical regions in older men [&lt;span&gt;1&lt;/span&gt;]. The findings underscore the value of automated opportunistic imaging for assessing sarcopenia and mortality risk in aging populations [&lt;span&gt;2&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;We commend the study's analysis and emphasis on functional outcomes, including grip strength, leg power, and walking speed. Nonetheless, the interpretation of results may benefit from a more thorough consideration of age as a potential residual confounder. Older participants naturally face a higher 10-year mortality risk. While age was included as a covariate, muscle size and density are strongly inversely correlated with age. Without accounting for age through matching or stratification, especially with the benefit of having a large cohort, the observed association between muscle metrics and mortality may be confounded by age.&lt;/p&gt;&lt;p&gt;Propensity score matching or age-stratified subgroup analyses could have further strengthened causal inference and minimized residual confounding. This is especially pertinent since the survival analyses showed consistent associations across regions—but without deeper exploration of whether these held across narrower age bands. It remains unclear whether poorer muscle metrics are independently predictive of mortality or simply reflect age-related risk of mortality.&lt;/p&gt;&lt;p&gt;From the health economic angle, where the cost of healthcare consumption is a pertinent marker of health in a given population, the authors could also consider analyzing, by decade bands of age, the association of muscle size and density with 1-year mortality, hospital attendance, or mean sick days, which would allow readers to better appreciate the impact of muscle size and quality on shorter term health-related outcomes. These parameters, with the strength of sample size, would allow more emphasis on muscle health in health promotion policies.&lt;/p&gt;&lt;p&gt;It was good of the authors to highlight differences with previous studies. The contrary findings regarding the association between muscle density and leg power in Korean older adults [&lt;span&gt;3&lt;/span&gt;] compared with the MrOS study participants highlight important ethnic and regional differences in the assessment, cut-offs, and variations in muscle strength, density, and intermuscular adipose tissue (IMAT) in different populations. Validation in diverse populations, especially older women and multi-ethnic Asian cohorts, is crucial for generalizability.&lt;/p&gt;&lt;p&gt;It would have been interesting for the authors to consider and highlight the associations between muscle mass, muscle function, muscle quality, and health-related outcomes [&lt;span&gt;4&lt;/span&gt;]. With increasing emphasis on muscle quality as a measurement metric for muscle health [&lt;span&gt;5, 6&lt;/span&gt;], future studies pertaining to muscle health should be encouraged to assess and present thes","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 1","pages":"286-287"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Comment on: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men 回复评论:CT肌肉面积和密度与老年男性各解剖区域功能结局和死亡率的关系。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-04 DOI: 10.1111/jgs.70129
Megan Hetherington-Rauth, Ashley A. Weaver, Peggy M. Cawthon
<p>We appreciate Tan et al.'s interest and comment on our recent manuscript, “Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men” [<span>1</span>]. They raise an important question about the role of age in the relationship of muscle area and density with risk of mortality. Although all models were adjusted for age, we acknowledge that standard covariate adjustment may not fully address or disentangle the confounding influence of age.</p><p>In response to the comments, we performed additional analyses to assess age as a potential effect modifier. We examined interactions between age and both muscle area and muscle density at two trunk levels (Trunk-L1 and Trunk-L3) and in the right (Thigh-RT) and left (Thigh-LT) thigh, using Cox proportional hazards models with age modeled both continuously and in tertiles. We also conducted age-stratified subgroup analyses based on age tertiles of our sample.</p><p>Figure 1 presents hazard ratios (HRs) (95% CI) per standard deviation increase in muscle density and area for 10-year all-cause mortality, stratified by age tertile and anatomical region. No significant age interactions were observed when age was modeled as a continuous variable (<i>p</i>-interaction > 0.05), and similar HRs were found across all the age tertiles, as indicated by overlapping 95% CIs. However, some region-specific patterns emerged. Trunk muscle density at both Trunk-L1 and Trunk-L3 was most strongly associated with lower mortality risk in the youngest age tertile, with weaker associations in older tertiles, although no statistically significant interaction was detected (<i>p</i>-interaction > 0.05). In contrast, thigh muscle density was most strongly associated with mortality in the middle tertile, with a significantly greater effect than in the youngest tertile for the Thigh-RT (<i>p</i>-interaction = 0.006) and a borderline difference for the Thigh-LT (<i>p</i>-interaction = 0.06). Unlike muscle density, muscle area was not significantly associated with mortality in the overall sample or within most age tertiles, except for the Thigh-RT, where a significant association was observed only in the youngest tertile and the full cohort.</p><p>These findings suggest that the impact of muscle density on mortality risk varies by both anatomical region and stage of aging. The stronger association observed in the youngest-old age tertile for trunk muscles, but in the middle-old age tertile for thigh muscles, may reflect differences in the onset and progression of age-related muscle quality decline across regions. Lumbar paraspinal muscles are particularly vulnerable to early degenerative changes, such as fat infiltration, even in relatively healthy adults, likely due to their sensitivity to disuse and neuromuscular dysfunction [<span>2, 3</span>]. As a result, lower muscle density in the trunk, primarily driven by decreased muscle density of the paraspinal muscles, may s
我们感谢Tan等人对我们最近的手稿的兴趣和评论,“CT肌肉面积和密度与老年男性各解剖区域的功能结果和死亡率的关系”bbb。他们提出了一个重要的问题,即年龄在肌肉面积和密度与死亡风险之间的关系中所起的作用。尽管所有模型都根据年龄进行了调整,但我们承认,标准协变量调整可能无法完全解决或理清年龄的混杂影响。为了回应这些评论,我们进行了额外的分析,以评估年龄作为潜在的影响调节因素。我们在两个躯干水平(躯干l1和躯干l3)以及右侧(大腿rt)和左侧(大腿lt)使用Cox比例风险模型研究了年龄与肌肉面积和肌肉密度之间的相互作用,该模型采用年龄连续建模和分位数建模。我们还根据样本的年龄三分位数进行了年龄分层亚组分析。图1显示了肌肉密度和面积每标准差增加的10年全因死亡率的风险比(hr) (95% CI),按年龄、分位和解剖区域分层。当年龄作为连续变量建模时,没有观察到显著的年龄相互作用(p-interaction > 0.05),并且在所有年龄分位数中发现相似的hr,如重叠的95% ci所示。然而,出现了一些特定区域的模式。尽管没有发现显著的交互作用(p-interaction > 0.05),但在年龄最小的三分虫中,树干l1和树干l3的躯干肌肉密度与较低的死亡风险相关性最强,而在年龄较大的三分虫中相关性较弱。相比之下,大腿肌肉密度与中间三分之一的死亡率关系最为密切,大腿- rt组的影响显著大于最年轻三分之一组(p-互作= 0.006),大腿- lt组的差异处于临界状态(p-互作= 0.06)。与肌肉密度不同,肌肉面积与整个样本或大多数年龄分位数的死亡率没有显着相关性,除了大腿- rt,其中仅在最年轻的分位数和整个队列中观察到显着相关性。这些发现表明,肌肉密度对死亡风险的影响因解剖区域和衰老阶段而异。在躯干肌肉的年轻-老年阶段观察到的更强的关联,但在中年阶段观察到的大腿肌肉的关联,可能反映了不同地区与年龄相关的肌肉质量下降的发生和进展的差异。腰椎棘旁肌特别容易发生早期退行性改变,如脂肪浸润,即使在相对健康的成年人中也是如此,这可能是由于它们对废用和神经肌肉功能障碍的敏感性[2,3]。因此,躯干较低的肌肉密度,主要是由脊柱旁肌肉密度下降引起的,可能是全身性衰退的早期标志,这可以解释其与年轻老年男性(即65-69岁)死亡率的更强关联。随着年龄的增长,脂肪浸润在躯干肌肉中变得更加普遍和广泛,变异性缩小,降低了肌肉密度测量的鉴别价值。与棘旁肌肉不同,大腿肌肉质量在衰老过程的后期趋于下降,通常与年龄相关的体力活动减少和新出现的功能障碍一致。因此,在中老年男性(70-75岁)中观察到更大的人与人之间的差异和与死亡率的更强关联,而在年轻老年男性中,大腿肌肉密度相对保持不变。在老年组(即76岁以上)中,肌肉退化更为普遍,这可能会降低肌肉质量的可变性,并限制其分层死亡风险的能力。这些结果强调了肌肉指标的预后意义,特别是那些反映肌肉质量的指标,在所有老年人的肌肉群中对生存率的影响并不统一。因此,在评估肌肉相关死亡风险时,研究和临床实践都应考虑区域特异性衰老模式。根据这一点,Tan等人强调,进一步检查肌肉大小和密度与短期健康结果(例如住院和病假)的关系,特别是在不同人群中,可以帮助改进针对年龄的评估和干预方法。M.H.-R。:形式分析,写作。A.A.W:写作。监督,写作。资助者在研究设计、方法、受试者招募、数据收集、分析和解释或论文准备中没有发挥任何作用。作者声明无利益冲突。本出版物链接到Tan等人的相关信函。要查看本文,请访问https://doi.org/10.1111/jgs.70133。
{"title":"Reply to Comment on: Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men","authors":"Megan Hetherington-Rauth,&nbsp;Ashley A. Weaver,&nbsp;Peggy M. Cawthon","doi":"10.1111/jgs.70129","DOIUrl":"10.1111/jgs.70129","url":null,"abstract":"&lt;p&gt;We appreciate Tan et al.'s interest and comment on our recent manuscript, “Associations of CT Muscle Area and Density With Functional Outcomes and Mortality Across Anatomical Regions in Older Men” [&lt;span&gt;1&lt;/span&gt;]. They raise an important question about the role of age in the relationship of muscle area and density with risk of mortality. Although all models were adjusted for age, we acknowledge that standard covariate adjustment may not fully address or disentangle the confounding influence of age.&lt;/p&gt;&lt;p&gt;In response to the comments, we performed additional analyses to assess age as a potential effect modifier. We examined interactions between age and both muscle area and muscle density at two trunk levels (Trunk-L1 and Trunk-L3) and in the right (Thigh-RT) and left (Thigh-LT) thigh, using Cox proportional hazards models with age modeled both continuously and in tertiles. We also conducted age-stratified subgroup analyses based on age tertiles of our sample.&lt;/p&gt;&lt;p&gt;Figure 1 presents hazard ratios (HRs) (95% CI) per standard deviation increase in muscle density and area for 10-year all-cause mortality, stratified by age tertile and anatomical region. No significant age interactions were observed when age was modeled as a continuous variable (&lt;i&gt;p&lt;/i&gt;-interaction &gt; 0.05), and similar HRs were found across all the age tertiles, as indicated by overlapping 95% CIs. However, some region-specific patterns emerged. Trunk muscle density at both Trunk-L1 and Trunk-L3 was most strongly associated with lower mortality risk in the youngest age tertile, with weaker associations in older tertiles, although no statistically significant interaction was detected (&lt;i&gt;p&lt;/i&gt;-interaction &gt; 0.05). In contrast, thigh muscle density was most strongly associated with mortality in the middle tertile, with a significantly greater effect than in the youngest tertile for the Thigh-RT (&lt;i&gt;p&lt;/i&gt;-interaction = 0.006) and a borderline difference for the Thigh-LT (&lt;i&gt;p&lt;/i&gt;-interaction = 0.06). Unlike muscle density, muscle area was not significantly associated with mortality in the overall sample or within most age tertiles, except for the Thigh-RT, where a significant association was observed only in the youngest tertile and the full cohort.&lt;/p&gt;&lt;p&gt;These findings suggest that the impact of muscle density on mortality risk varies by both anatomical region and stage of aging. The stronger association observed in the youngest-old age tertile for trunk muscles, but in the middle-old age tertile for thigh muscles, may reflect differences in the onset and progression of age-related muscle quality decline across regions. Lumbar paraspinal muscles are particularly vulnerable to early degenerative changes, such as fat infiltration, even in relatively healthy adults, likely due to their sensitivity to disuse and neuromuscular dysfunction [&lt;span&gt;2, 3&lt;/span&gt;]. As a result, lower muscle density in the trunk, primarily driven by decreased muscle density of the paraspinal muscles, may s","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 1","pages":"288-289"},"PeriodicalIF":4.5,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145226564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Geriatricians Leading Innovation: Collaborating to Enhance Care as We Age 老年病学家引领创新:合作加强老年护理。
IF 4.5 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2025-10-03 DOI: 10.1111/jgs.70102
Nancy E. Lundebjerg, Megan Young, Helen M. Fernandez, Eric Widera, Peter M. Abadir

In the early 20th century, Geriatric Medicine emerged as a specialty with a focus on improving the health and quality of life of older adults. Almost since inception, geriatricians have worked in collaboration with other medical specialties and health professionals to achieve this goal. This focus on collaboration has led to innovations that are improving care for older adults across settings of care, some of which are being led by other specialties (e.g., the Geriatric Surgery Verification Program). In 2015, Geriatric Medicine began to recruit fellows through the National Resident Matching Program (NRMP), and data from the past 10 years (2015–2024) reflect stable recruitment into the field with approximately 300 fellows entering geriatrics fellowship annually. The field has been innovative in its efforts to create training pathways that support physicians to complete geriatrics fellowship, including national pilots that combine geriatrics and palliative care training and offer clinical geriatrics experiences during internal and family medicine residency training underway at the Accreditation Council for Graduate Medical Education. In research, the field has contributed to extending our collective healthspan, championed inclusion of older adults in all research, and led efforts to develop investigators who are focused on the geriatrics aspects of their research. Opportunities for geriatricians to build on the foundations they have laid include leading Age-Friendly Health Systems and artificial intelligence into healthcare implementation with a continued focus on partnering with others to achieve meaningful change in the health and well-being of others.

在20世纪初,老年医学作为一门专业出现,其重点是改善老年人的健康和生活质量。几乎自成立以来,老年病医生一直与其他医学专业和卫生专业人员合作,以实现这一目标。这种对合作的重视带来了创新,改善了对老年人的护理,其中一些由其他专业(例如,老年外科验证项目)领导。2015年,老年病医学开始通过国家住院医师匹配计划(NRMP)招募研究员,过去10年(2015-2024)的数据反映了该领域的稳定招聘,每年约有300名研究员进入老年病医学奖学金。该领域一直在创新,努力创建培训途径,支持医生完成老年医学奖学金,包括结合老年医学和姑息治疗培训的国家试点,并在研究生医学教育认证委员会正在进行的内科和家庭医学住院医师培训期间提供临床老年医学经验。在研究方面,该领域为延长我们的集体健康寿命做出了贡献,倡导将老年人纳入所有研究,并领导努力培养专注于老年病学方面的研究人员。老年病医生有机会在他们已经奠定的基础上再接再厉,包括将老年人友好型卫生系统和人工智能引入医疗保健实施,并继续注重与他人合作,为他人的健康和福祉实现有意义的改变。
{"title":"Geriatricians Leading Innovation: Collaborating to Enhance Care as We Age","authors":"Nancy E. Lundebjerg,&nbsp;Megan Young,&nbsp;Helen M. Fernandez,&nbsp;Eric Widera,&nbsp;Peter M. Abadir","doi":"10.1111/jgs.70102","DOIUrl":"10.1111/jgs.70102","url":null,"abstract":"<div>\u0000 \u0000 <p>In the early 20th century, Geriatric Medicine emerged as a specialty with a focus on improving the health and quality of life of older adults. Almost since inception, geriatricians have worked in collaboration with other medical specialties and health professionals to achieve this goal. This focus on collaboration has led to innovations that are improving care for older adults across settings of care, some of which are being led by other specialties (e.g., the Geriatric Surgery Verification Program). In 2015, Geriatric Medicine began to recruit fellows through the National Resident Matching Program (NRMP), and data from the past 10 years (2015–2024) reflect stable recruitment into the field with approximately 300 fellows entering geriatrics fellowship annually. The field has been innovative in its efforts to create training pathways that support physicians to complete geriatrics fellowship, including national pilots that combine geriatrics and palliative care training and offer clinical geriatrics experiences during internal and family medicine residency training underway at the Accreditation Council for Graduate Medical Education. In research, the field has contributed to extending our collective healthspan, championed inclusion of older adults in all research, and led efforts to develop investigators who are focused on the geriatrics aspects of their research. Opportunities for geriatricians to build on the foundations they have laid include leading Age-Friendly Health Systems and artificial intelligence into healthcare implementation with a continued focus on partnering with others to achieve meaningful change in the health and well-being of others.</p>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 2","pages":"316-325"},"PeriodicalIF":4.5,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of the American Geriatrics Society
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1