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Life-sustaining treatment decisions and family evaluations of end-of-life care for Veteran decedents in Department of Veterans Affairs nursing homes 退伍军人事务部疗养院中退伍军人死者临终护理的维持生命治疗决定和家属评估。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-06 DOI: 10.1111/jgs.19050
Cari Levy MD, PhD, Aryan Esmaeili MD, PhD, Dawn Smith MS, Robert V. Hogikyan MD, MPH, Vyjeyanthi S. Periyakoil MD, Joan G. Carpenter PhD, CRNP, Anne Sales PhD, RN, Ciaran S. Phibbs PhD, Andrew Murray BS, Mary Ersek PhD, RN, FPCN

Background

Modeled after the Physician Orders for Life Sustaining Treatment program, the Veterans Health Administration (VA) implemented the Life-Sustaining Treatment (LST) Decisions Initiative to improve end-of-life outcomes by standardizing LST preference documentation for seriously ill Veterans. This study examined the associations between LST documentation and family evaluation of care in the final month of life for Veterans in VA nursing homes.

Methods

Retrospective, cross-sectional analysis of data for decedents in VA nursing homes between July 1, 2018 and January 31, 2020 (N = 14,575). Regression modeling generated odds for key end-of-life outcomes and family ratings of care quality.

Results

LST preferences were documented for 12,928 (89%) of VA nursing home decedents. Contrary to our hypothesis, neither receipt of wanted medications and medical treatment (adjusted odds ratio [OR]: 0.85, 95% confidence interval [CI] 0.63, 1.16) nor ratings of overall care in the last month of life (adjusted OR: 0.96, 95% CI 0.76, 1.22) differed significantly between those with and without completed LST templates in adjusted analyses.

Conclusions

Among Community Living Center (CLC) decedents, 89% had documented LST preferences. No significant differences were observed in family ratings of care between Veterans with and without documentation of LST preferences. Interventions aimed at improving family ratings of end-of-life care quality in CLCs should not target LST documentation in isolation of other factors associated with higher family ratings of end-of-life care quality.

背景:退伍军人健康管理局(VA)以 "维持生命治疗医嘱 "计划为蓝本,实施了 "维持生命治疗(LST)决定倡议",旨在通过规范重病退伍军人的LST偏好文件来改善临终结局。本研究调查了退伍军人管理局疗养院中退伍军人生命最后一个月的生命维持治疗文件和家属对护理评估之间的关联:对 2018 年 7 月 1 日至 2020 年 1 月 31 日期间退伍军人疗养院中死者的数据进行回顾性横截面分析(N = 14575)。回归建模生成主要临终结局和家属对护理质量评价的几率:12928名(89%)退伍军人疗养院死者记录了LST偏好。与我们的假设相反,在调整后的分析中,接受想要的药物和医疗治疗(调整后的几率比 [OR]:0.85,95% 置信区间 [CI]:0.63, 1.16)和生命最后一个月对整体护理的评价(调整后的几率比 [OR]:0.96,95% 置信区间 [CI]:0.76, 1.22)在有完成 LST 模板和没有完成 LST 模板的患者之间没有显著差异:结论:在社区生活中心(CLC)的死者中,89%的人记录了LST偏好。有和没有 LST 偏好记录的退伍军人的家属对护理的评价没有明显差异。旨在改善社区生活中心家属对临终关怀质量评价的干预措施不应脱离与家属对临终关怀质量评价较高相关的其他因素而孤立地以LST记录为目标。
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引用次数: 0
Daily care hours among caregivers of older emergency department patients with dementia and undiagnosed cognitive impairment 患有痴呆症和未确诊认知障碍的老年急诊患者的护理人员每天的护理时间。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-05 DOI: 10.1111/jgs.19062
James Galske BS, Tonya Chera BPH, Ula Hwang MD, MPH, Joan K. Monin PhD, Arjun Venkatesh MD, MBA, MHS, Kenneth Lam MD, MAS, Amanda N. Leggett PhD, MS, Cameron Gettel MD, MHS
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引用次数: 0
Don't die with your boots on 不要穿着靴子死去。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-05 DOI: 10.1111/jgs.19059
Dean Gianakos MD, FACP
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引用次数: 0
The geriatric trauma hospitalist service: An analysis of a management strategy for injured older adults 老年创伤住院医师服务:分析受伤老年人的管理策略。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-05 DOI: 10.1111/jgs.19054
Heather R. Kregel MD, MS, Claudia Pedroza PhD, Fatimah Sunez BS, Gina Khraish MD, Ezenwa Onyema MD, David E. Meyer MD, Sasha D. Adams MD, Lillian S. Kao MD, MS, Laura J. Moore MD, Thaddeus J. Puzio MD

Background

Management of geriatric trauma patients requires balancing chronic comorbidities with acute injuries. We developed a care model in which patients are managed by hospitalists with trauma-centered education and hypothesized that clinical outcomes would be similar to outcomes in patients primarily managed by trauma surgeons.

Methods

This was a retrospective study of trauma patients aged ≥65 from January 2020 to December 2021. Groups were defined by admitting service: trauma surgery service (TSS) or geriatric trauma hospitalist service (GTHS). The primary outcome was in-hospital mortality. Regression analyses and inverse probability treatment weighted (IPTW) propensity score (PS) analyses were performed to determine the association between admitting service and outcomes.

Results

A total of 1004 patients were eligible for inclusion—580 GTHS and 424 TSS admissions. GTHS patients were older (82 vs. 74, p < 0.001), more likely to have suffered blunt trauma (99.5% vs. 95%, p < 0.001), more likely to have comorbidities (91.2% vs. 87%, p < 0.001), had higher Charlson Comorbidity Indexes (CCIs), and had lower median injury severity scores (9 vs. 13, p < 0.001). Rates of mortality, delirium, 30-day readmission, and overall complications were low and similar between groups. While TSS patients were likely to be discharged home, GTHS had more discharges to skilled nursing facilities and longer length of stay (LOS). On multivariable analysis adjusted for age, ISS, CCI, and sex, patients admitted to GTHS had lower odds of death with an odds ratio of 0.15 (95% confidence interval [CI] 0.02–0.75, p = 0.03) when compared to TSS. On IPTW PS analysis, patients admitted to GTHS had similar odds of death with an odds ratio of 0.3 (95% CI 0.06–1.6, p = 0.16).

Conclusions

Protocolized admission criteria to a GTHS resulted in similar low mortality rates but longer LOS when compared to patients admitted to a TSS. This care model may inform other trauma centers in developing their strategies for managing the increasing volume of vulnerable injured older adults.

背景:老年创伤患者的管理需要兼顾慢性合并症和急性损伤。我们开发了一种护理模式,由接受过以创伤为中心的教育的住院医师管理患者,并假设临床结果将与主要由创伤外科医生管理的患者结果相似:这是一项回顾性研究,研究对象是 2020 年 1 月至 2021 年 12 月年龄≥65 岁的创伤患者。根据入院服务确定分组:创伤外科服务(TSS)或老年创伤住院医师服务(GTHS)。主要结果是院内死亡率。通过回归分析和反概率治疗加权(IPTW)倾向评分(PS)分析来确定入院服务与结果之间的关联:共有 1004 名患者符合纳入条件,其中 580 名为 GTHS 患者,424 名为 TSS 患者。GTHS患者的年龄更大(82岁对74岁,P 结论:GTHS患者的年龄更大:与 TSS 相比,GTHS 的规范化入院标准导致了相似的低死亡率,但较长的 LOS。这种护理模式可为其他创伤中心提供借鉴,帮助他们制定策略,管理日益增多的易受伤老年人。
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引用次数: 0
Cover 封面
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-04 DOI: 10.1111/jgs.17863
Inessa Cohen MPH, Rohit B. Sangal MD, MBA, Richard Andrew Taylor MD, MHS, Anna Crawford MS, James M. Lai MD, MHS, Pamela Martin APRN, Sarah Palleschi PA, Craig Rothenberg MPH, Debra Tomasino MA, Ula Hwang MD, MPH

Cover caption: A cartoon image generated with assistance of AI showing a contrast between a busy versus organized geriatric emergency department with (right) and without (left) the GEMS intervention. OpenAI. (2024). ChatGPT [Large language model]. For full details, see “Impact of the geriatric emergency medicine specialist intervention on final emergency department disposition” on page 2017.

封面标题:在人工智能协助下生成的卡通图片,显示了有 GEMS 干预措施(右)和无 GEMS 干预措施(左)的老年急诊科之间繁忙与井然有序的对比。OpenAI.(2024).ChatGPT [大型语言模型]。详见第 2017 页 "老年急诊医学专家干预对急诊科最终处置的影响"。
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引用次数: 0
Time to surgical treatment for hip fracture care 髋部骨折护理的手术治疗时间。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-04 DOI: 10.1111/jgs.19063
Haoyan Zhong MPA, Jashvant Poeran MD, PhD, Alex Illescas MPH, Lisa Reisinger MD, Crispiana Cozowicz MD, Stavros G. Memtsoudis MD, PhD, MBA, Jiabin Liu MD, PhD, FASA

Background

Studies have demonstrated beneficial outcomes associated with timely surgical treatment of hip fracture. Subsequently, practice recommendations changed with 24–48 h as the recommended time for surgery from admission; however, recent data on timing of hip fracture surgery and how this impacts outcomes are lacking.

Methods

This retrospective cohort study included patients who had a primary diagnosis of hip fracture and underwent a subsequent surgical repair within 3 days of admission (Premier Healthcare claims 2006–2021 data). The primary exposure of interest was time from hip fracture diagnosis to surgery (categorized as 0–1 day, 2 days, and 3 days). Outcomes included any major complication, mortality, and intensive care unit (ICU) admission. Mixed-effects models measured the association between timing of surgery and outcomes. We report odds ratios (OR) and 95% confidence intervals.

Results

Among 501,267 surgical hip fracture patients, 26.0%, 56.0%, and 18.1% of patients received surgery on days 0–1, 2, and 3, respectively. The median ages were 83, 84, and 84 years old, and there were 73.3%, 72.2%, and 68.8% female in each group respectively. Compared with repair on day 0–1, hip fracture surgical treatment on day 2 or day 3 was associated with increased odds of major complications (OR 1.06, 95% CI 1.03–1.08 and OR 1.17, 95% CI 1.13–1.2), mortality (OR 1.08, 95% CI 1.02–1.14 and OR 1.2, 95% CI 1.12–1.28), and ICU admission (OR 1.06, 95% CI 1.04–1.09 and OR 1.36, 95% CI 1.32–1.4) after adjusting major comorbidities; all p < 0.001.

Conclusion

Despite the publication of society guidelines in 2015, most fracture patients still received surgery on day 2 or day 3 of admission and were associated with worse outcomes. Balancing optimization of clinical factors with timing of surgery can be challenging, and further research is needed. Nonetheless, our findings reiterate the importance of timely surgical intervention.

背景:研究表明,及时进行髋部骨折手术治疗有助于提高疗效。随后,实践建议将入院后 24-48 小时作为手术的推荐时间;然而,关于髋部骨折手术时机以及这对治疗效果有何影响的最新数据尚缺:这项回顾性队列研究纳入了初诊为髋部骨折并在入院后 3 天内接受后续手术修复的患者(Premier Healthcare 索赔 2006-2021 年数据)。主要关注点是从髋部骨折诊断到手术的时间(分为 0-1 天、2 天和 3 天)。结果包括任何主要并发症、死亡率和入住重症监护室 (ICU)。混合效应模型测量了手术时间与结果之间的关系。我们报告了几率比(OR)和 95% 的置信区间:在 501,267 例髋部骨折手术患者中,分别有 26.0%、56.0% 和 18.1% 的患者在第 0-1 天、第 2 天和第 3 天接受手术。年龄中位数分别为 83 岁、84 岁和 84 岁,女性比例分别为 73.3%、72.2% 和 68.8%。与在第 0-1 天进行修复相比,在第 2 天或第 3 天进行髋部骨折手术治疗与主要并发症(OR 1.06,95% CI 1.03-1.08 和 OR 1.17,95% CI 1.13-1.2)、死亡率(OR 1.08,95% CI 1.02-1.14 和 OR 1.2,95% CI 1.12-1.28)以及在调整主要合并症后入住 ICU(OR 1.06,95% CI 1.04-1.09 和 OR 1.36,95% CI 1.32-1.4);所有 p 结论:尽管社会指南已于2015年发布,但大多数骨折患者仍在入院第2天或第3天接受手术,且预后较差。在优化临床因素与手术时机之间取得平衡具有挑战性,需要进一步研究。尽管如此,我们的研究结果重申了及时手术干预的重要性。
{"title":"Time to surgical treatment for hip fracture care","authors":"Haoyan Zhong MPA,&nbsp;Jashvant Poeran MD, PhD,&nbsp;Alex Illescas MPH,&nbsp;Lisa Reisinger MD,&nbsp;Crispiana Cozowicz MD,&nbsp;Stavros G. Memtsoudis MD, PhD, MBA,&nbsp;Jiabin Liu MD, PhD, FASA","doi":"10.1111/jgs.19063","DOIUrl":"10.1111/jgs.19063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Studies have demonstrated beneficial outcomes associated with timely surgical treatment of hip fracture. Subsequently, practice recommendations changed with 24–48 h as the recommended time for surgery from admission; however, recent data on timing of hip fracture surgery and how this impacts outcomes are lacking.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included patients who had a primary diagnosis of hip fracture and underwent a subsequent surgical repair within 3 days of admission (Premier Healthcare claims 2006–2021 data). The primary exposure of interest was time from hip fracture diagnosis to surgery (categorized as 0–1 day, 2 days, and 3 days). Outcomes included any major complication, mortality, and intensive care unit (ICU) admission. Mixed-effects models measured the association between timing of surgery and outcomes. We report odds ratios (OR) and 95% confidence intervals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 501,267 surgical hip fracture patients, 26.0%, 56.0%, and 18.1% of patients received surgery on days 0–1, 2, and 3, respectively. The median ages were 83, 84, and 84 years old, and there were 73.3%, 72.2%, and 68.8% female in each group respectively. Compared with repair on day 0–1, hip fracture surgical treatment on day 2 or day 3 was associated with increased odds of major complications (OR 1.06, 95% CI 1.03–1.08 and OR 1.17, 95% CI 1.13–1.2), mortality (OR 1.08, 95% CI 1.02–1.14 and OR 1.2, 95% CI 1.12–1.28), and ICU admission (OR 1.06, 95% CI 1.04–1.09 and OR 1.36, 95% CI 1.32–1.4) after adjusting major comorbidities; all <i>p</i> &lt; 0.001.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Despite the publication of society guidelines in 2015, most fracture patients still received surgery on day 2 or day 3 of admission and were associated with worse outcomes. Balancing optimization of clinical factors with timing of surgery can be challenging, and further research is needed. Nonetheless, our findings reiterate the importance of timely surgical intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"72 11","pages":"3492-3500"},"PeriodicalIF":4.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141499967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Social media discourse on ageism, sexism, and racism: Analysis of 150 million tweets over 15 years 社交媒体上关于年龄歧视、性别歧视和种族主义的讨论:对 15 年间 1.5 亿条推文的分析。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-03 DOI: 10.1111/jgs.19047
Reuben Ng PhD, Nicole Indran BSocSci (Hons), Luyao Liu MSc

Background

Ageism is a major but oft-overlooked social determinant of health. In fact, it is widely accepted among scholars that ageism is one of the least acknowledged forms of inequality, although few empirical attempts have been made to substantiate this claim. This is the first study that quantifies the amount of discourse dedicated to ageism, sexism, and racism on Twitter. Specifically, we rely on the usage of hashtags as a proxy for the frequency of discussions surrounding each form of inequality over a 15-year period from 2007 to 2022. We also identify key events that triggered spikes in Twitter activity for each form of inequality.

Methods

Hashtags related to racism and sexism were extracted from past scholarship. We also employed a snowball sampling method whereby we queried the hashtags using Twitter's search function to identify other hashtags. As limited research has been conducted on ageism-related hashtags, we queried hashtags utilized by advocacy groups and adopted a snowball sampling method to compile other relevant hashtags. Tweets collected (N = 154,353,047) spanned 15 years, from August 23, 2007 to December 31, 2022.

Results

From 2007 to 2022, racism-related hashtags were used the most, followed by sexism-related hashtags and ageism-related hashtags. Racism-related hashtags (N = 99,250,348) were mentioned about 60 times more than ageism-related hashtags (N = 1,648,926). Sexism-related hashtags (N = 38,933,113) were mentioned 24 times more than ageism-related hashtags. The increasing linear trend of tweets associated with ageism (p < 0.001), sexism (p < 0.05), and racism (p < 0.05) reached significance. Incidents of racism and sexism often generated widespread public outrage. Conversely, instances of ageism rarely caused spikes in social media activity. Rather, these spikes were mainly observed during events such as the release of a report on ageism, a conference related to aging, or observances such as International Day of Older Persons.

Conclusion

There is a need to hasten moves to raise awareness of ageism. To ensure that discussions on ageism are not confined to academic and policy circles, advocacy campaigns could be held to educate the public on the issue and its negative concomitants.

背景:老龄歧视是影响健康的一个主要社会决定因素,但却常常被忽视。事实上,学者们普遍认为,年龄歧视是最不被承认的不平等形式之一,但很少有人尝试通过实证研究来证实这一说法。这是第一项对推特上有关年龄歧视、性别歧视和种族主义的言论数量进行量化的研究。具体来说,我们以标签的使用量来代表 2007 年至 2022 年这 15 年间围绕每种不平等形式的讨论频率。方法:我们从过去的学术研究中提取了与种族主义和性别歧视相关的标签。我们还采用了 "滚雪球 "取样法,即使用 Twitter 的搜索功能查询标签,以确定其他标签。由于对年龄歧视相关标签的研究有限,我们查询了倡导团体使用的标签,并采用滚雪球式抽样方法收集了其他相关标签。收集到的推文(N = 154,353,047 条)时间跨度为 15 年,从 2007 年 8 月 23 日至 2022 年 12 月 31 日:从 2007 年到 2022 年,与种族主义相关的标签使用最多,其次是与性别歧视相关的标签和与年龄歧视相关的标签。与种族主义相关的标签(N = 99,250,348 个)比与年龄歧视相关的标签(N = 1,648,926 个)多出约 60 倍。与性别歧视相关的标签(N=38,933,113)比与年龄歧视相关的标签多 24 倍。与年龄歧视相关的推文呈线性增长趋势(p 结论):有必要加快提高对老龄歧视的认识。为确保有关老龄歧视的讨论不局限于学术界和政策界,可开展宣传活动,让公众了解这一问题及其负面影响。
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引用次数: 0
Commercial entities own the online narrative on home care: Impacts on quality, content, and readability 商业实体拥有关于家庭护理的在线叙述:对质量、内容和可读性的影响。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-03 DOI: 10.1111/jgs.19041
Elizabeth Goldberg MD, ScM, Megan Bounds MPH, Peter Serina MD, MPH, Jonathan Gomez Picazo, Daphne Lo BS, Samantha Roberts MS, Hari Dandapani BA, Sarah Keene MD, PhD, Kali Thomas PhD, MA, Andrew Leroux PhD
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引用次数: 0
The Florida Geriatric Head Trauma CT Clinical Decision Rule 佛罗里达州老年头部创伤 CT 临床决策规则。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-03 DOI: 10.1111/jgs.19057
Richard D. Shih MD, Scott M. Alter MD, Mike Wells MBBCh, PhD, Joshua J. Solano MD, Gabriella Engstrom PhD, RN, Lisa M. Clayton DO, Patrick G. Hughes DO, Lara Goldstein MBBCh, PhD, Lawrence Lottenberg MD, Joseph G. Ouslander MD

Background

Several clinical decision rules have been devised to guide head computed tomography (CT) use in patients with minor head injuries, but none have been validated in patients 65 years or older. We aimed to derive and validate a head injury clinical decision rule for older adults.

Methods

We conducted a secondary analysis of an existing dataset of consecutive emergency department (ED) patients >65 years old with blunt head trauma. The main predictive outcomes were significant intracranial injury and Need for Neurosurgical Intervention on CT. The secondary outcomes also considered in the model development and validation were All Injuries and All Intracranial Injuries. Predictor variables were identified using multiple variable logistic regression, and clinical decision rule models were developed in a split-sample derivation cohort and then tested in an independent validation cohort.

Results

Of 5776 patients, 233 (4.0%) had significant intracranial injury and an additional 104 (1.8%) met CT criteria for Need for Neurosurgical Intervention. The best performing model, the Florida Geriatric Head Trauma CT Clinical Decision Rule, assigns points based on several clinical variables. If the points totaled 25 or more, a CT scan is indicated. The included predictors were arrival via Emergency Medical Services (+30 points), Glasgow Coma Scale (GCS) <15 (+20 points), GCS <14 (+50 points), antiplatelet medications (+17 points), loss of consciousness (+16 points), signs of basilar skull fracture (+50 points), and headache (+20 points). Utilizing this clinical decision rule in the validation cohort, a point total ≥25 had a sensitivity and specificity of 100.0% (95% CI: 96.0–100) and 12.3% (95% CI: 10.9–13.8), respectively, for significant intracranial injury and Need for Neurosurgical Intervention.

Conclusions

The Florida Geriatric Head Trauma CT Clinical Decision Rule has the potential to reduce unnecessary CT scans in older adults, without compromising safe emergency medicine practice.

背景:目前已设计出几种临床决策规则来指导头部轻微损伤患者使用头部计算机断层扫描(CT),但没有一种规则在 65 岁或以上的患者中得到验证。我们的目标是为老年人制定并验证头部损伤临床决策规则:我们对现有的急诊科(ED)连续数据集进行了二次分析,该数据集包含年龄大于 65 岁的钝性头部外伤患者。主要的预测结果是明显的颅内损伤和 CT 神经外科干预需求。在模型开发和验证过程中还考虑了次要结果,即所有损伤和所有颅内损伤。使用多变量逻辑回归确定了预测变量,并在分离样本衍生队列中开发了临床决策规则模型,然后在独立验证队列中进行了测试:在 5776 名患者中,有 233 人(4.0%)有明显的颅内损伤,另有 104 人(1.8%)符合需要神经外科干预的 CT 标准。表现最好的模型是佛罗里达老年头部创伤 CT 临床决策规则,它根据几个临床变量分配分数。如果总分达到或超过 25 分,则需要进行 CT 扫描。其中的预测因素包括通过紧急医疗服务到达(+30 分)、格拉斯哥昏迷量表(GCS)结论:佛罗里达州老年头部创伤 CT 临床决策规则有可能减少老年人不必要的 CT 扫描,同时又不影响安全的急诊医学实践。
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引用次数: 0
Cross-sectional and longitudinal associations among healthcare costs and deficit accumulation 医疗费用与赤字积累之间的横向和纵向关联。
IF 4.3 2区 医学 Q1 GERIATRICS & GERONTOLOGY Pub Date : 2024-07-01 DOI: 10.1111/jgs.19053
Mark A. Espeland PhD, Ann S. M. Harada PhD, Johnathan Ross BS, Michael P. Bancks PhD, Nicholas M. Pajewski PhD, Felicia R. Simpson PhD, Michael Walkup MS, Ian Davis MA, Peter J. Huckfeldt PhD, for the Action for Health in Diabetes Aging Study Group

Background

Type 2 diabetes mellitus and overweight/obesity increase healthcare costs. Both are also associated with accelerated aging. However, the contributions of this accelerated aging to increased healthcare costs are unknown.

Methods

We use data from a 8-year longitudinal cohort followed at 16 U.S. clinical research sites. Participants were adults aged 45–76 years with established type 2 diabetes and overweight or obesity who had enrolled in the Action for Health in Diabetes clinical trial. They were randomly (1:1) assigned to either an intensive lifestyle intervention focused on weight loss versus a comparator of diabetes support and education. A validated deficit accumulation frailty index (FI) was used to characterize biological aging. Discounted annual healthcare costs were estimated using national databases in 2012 dollars. Descriptive characteristics were collected by trained and certified staff.

Results

Compared with participants in the lowest tertile (least frail) of baseline FI, those in the highest tertile (most frail) at Year 1 averaged $714 (42%) higher medication costs, $244 (22%) higher outpatient costs, and $800 (134%) higher hospitalization costs (p < 0.001). At Years 4 and 8, relatively greater increases in FI (third vs. first tertile) were associated with an approximate doubling of total healthcare costs (p < 0.001). Mean (95% confidence interval) relative annual savings in healthcare costs associated with randomization to the intensive lifestyle intervention were $437 ($195, $579) per year during Years 1–4 and $461 ($232, $690) per year during Years 1–8. These were attenuated and the 95% confidence interval no longer excluded $0 after adjustment for the annual FI differences from baseline.

Conclusions

Deficit accumulation frailty tracks well with healthcare costs among adults with type 2 diabetes and overweight or obesity. It may serve as a useful marker to project healthcare needs and as an intermediate outcome in clinical trials.

背景:2 型糖尿病和超重/肥胖症会增加医疗成本。这两种疾病还与加速衰老有关。然而,这种加速衰老对医疗成本增加的贡献尚不清楚:我们使用了 16 个美国临床研究机构的 8 年纵向队列数据。参与者为年龄在 45-76 岁之间、患有 2 型糖尿病和超重或肥胖症的成年人,他们都参加了 "糖尿病患者健康行动 "临床试验。他们被随机(1:1)分配到以减肥为重点的强化生活方式干预与糖尿病支持和教育的比较方案中。采用经过验证的赤字累积虚弱指数(FI)来描述生物衰老的特征。使用国家数据库估算了以 2012 年美元计算的年度医疗成本。由经过培训和认证的工作人员收集描述性特征:结果:与基线 FI 最低三等分组(最虚弱)的参与者相比,第一年时最高三等分组(最虚弱)的参与者平均用药费用高出 714 美元(42%),门诊费用高出 244 美元(22%),住院费用高出 800 美元(134%)(P 结论:虚弱程度与基线 FI 的变化密切相关:在患有 2 型糖尿病和超重或肥胖症的成年人中,虚弱累积与医疗费用密切相关。它可作为预测医疗保健需求的有用标记,也可作为临床试验的中间结果。
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Journal of the American Geriatrics Society
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