Journal of the American Geriatrics Society最新文献

{"title":"Use of Drugs With Actionable Pharmacogenetic Biomarkers and Possible Prescribing Changes Among Older People","authors":"Zinan Zhao,&nbsp;Yuxuan Zhao,&nbsp;Xiaowen Hu,&nbsp;Xue Wang,&nbsp;Gengchen Wang,&nbsp;Xinyi Zhang,&nbsp;Wenliang Dong,&nbsp;Luwen Shi,&nbsp;Xiaodong Guan,&nbsp;Christine Y. Lu,&nbsp;Pengfei Jin,&nbsp;Xiaoyan Nie","doi":"10.1111/jgs.70126","DOIUrl":"10.1111/jgs.70126","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pharmacogenetic testing offers a pathway to safer prescribing and improved outcomes in older adults, who face heightened risks of adverse drug reactions due to polypharmacy and age-related metabolic changes. This study evaluates the prevalence of actionable pharmacogenetic biomarker use and estimates the potential impact of genotype-guided dosing in Chinese older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cross-sectional analysis utilized 2015–2017 claims data from the China Health Insurance Research Association (CHIRA), encompassing 3,309,025 older patients (≥ 65 years) and 74,415,484 prescriptions. Drugs with Clinical Pharmacogenomics Implementation Consortium (CPIC) Level A evidence for actionable pharmacogenetic variants (<i>n</i> = 53) were identified. Key measures included the prescribing prevalence of Level A drugs and projected rates of actionable phenotype-driven dosing changes, calculated using population-specific genotype frequencies from PharmGKB and published sources.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among older adults, 43.4% (433.8 per 1000) were prescribed ≥ 1 CPIC Level A drug. Atorvastatin (131.1 per 1000), omeprazole (124.3 per 1000), and clopidogrel (75.7 per 1000) were the most common. Over one-third (36.5%; 365.3 per 1000) of exposures required genotype-guided dose adjustments, with clopidogrel (CYP2C19) and statins (SLCO1B1) representing the highest-priority gene-drug interactions (259.6 and 221.8 per 1000, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CPIC Level A pharmacogenetic biomarkers are prevalent in Chinese older adults, with over 40% exposed to actionable gene-drug pairs and 36.5% requiring dose adjustments. These findings highlight the clinical imperative to integrate pharmacogenetic testing into geriatric care, prioritize CYP2C19 and SLCO1B1 testing, and develop region-specific guidelines to mitigate polypharmacy risks. Policymakers and clinicians should consider targeted implementation strategies to optimize prescribing safety and efficacy in aging populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3679-3689"},"PeriodicalIF":4.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12748018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worldwide Burden of Pulmonary Arterial Hypertension in Adults Aged 65 Years and Older From 1990 to 2021","authors":"Liping Zhou,&nbsp;Jiayu Luo,&nbsp;Chaofeng Tan,&nbsp;Ying Li,&nbsp;Chang Peng,&nbsp;Kai Sun","doi":"10.1111/jgs.70135","DOIUrl":"10.1111/jgs.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aims to characterize the global epidemiological burden of pulmonary arterial hypertension (PAH) among elderly populations from 1990 to 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Leveraging data from the Global Burden of Disease Study 2021, we conducted a comprehensive analysis of PAH-related prevalence, incidence, mortality, and disability-adjusted life years (DALYs) across 204 countries and territories. The sociodemographic index (SDI) was employed to evaluate the association between socioeconomic development and PAH burden in aging populations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The global incidence and mortality of PAH among the elderly population has shown a significant upward trend. In 2021, there were 11,730 incident cases and 14,295 deaths due to PAH in the elderly worldwide. Age-standardized prevalence and incidence rates remained relatively stable, while mortality and DALY rates demonstrated a declining trend. China reported the highest number of incident cases and deaths in 2021. The peak mortality was observed in the 80–84 age group, with mortality rates generally increasing with age and being higher in females compared to males. Furthermore, age-standardized incidence rates exhibited a notable negative correlation with the SDI, decreasing as SDI increased.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our findings provided a novel global perspective on the temporal trends of PAH burden in the elderly population, augmenting the existing evidence and understanding of PAH epidemiology in this demographic. Additionally, these results identify gaps in various aspects of prevention, management, and intervention strategies for PAH in the elderly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3700-3707"},"PeriodicalIF":4.5,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Ceiling Fans on Core Temperature in Bed-Resting Older Adults Exposed to Indoor Overheating","authors":"Fergus K. O'Connor,&nbsp;Robert D. Meade,&nbsp;Kristina-Marie T. Janetos,&nbsp;Caroline Li-Maloney,&nbsp;Ronald J. Sigal,&nbsp;Pierre Boulay,&nbsp;Glen P. Kenny","doi":"10.1111/jgs.70109","DOIUrl":"10.1111/jgs.70109","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Rising global temperatures have increased indoor overheating risks, posing significant health threats to vulnerable populations, particularly older adults. While electric fans are recommended for cooling at temperatures up to 40°C, the efficacy of ceiling fans in very warm indoor temperatures (~31°C) remains understudied. This randomized study evaluated the efficacy of ceiling fans in reducing core temperature and cardiovascular strain among bed-resting adults exposed to simulated indoor overheating (31°C, 45% relative humidity) for 8 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty participants (12 females, median [IQR] age: 71 [68–73] years) underwent two experimental exposures with a ceiling fan set at either 0 m/s (control) or ~1.5 m/s (fan condition).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The primary outcome, peak core temperature, was significantly lowered by 0.2 [95% CI: 0.1–0.3]°C (0.4 [0.2–0.5]°F, <i>p</i> &lt; 0.001) with fan use (mean [SD]) 37.6 [0.2]°C (99.7 [0.4]°F); +0.9 [0.3]°C (+1.6 [0.5]°F) vs. pre-exposure) compared to control (37.8 [0.2]°C (100.0 [0.4]°F); +1.1 [0.5]°C (+2.0 [0.9]°F) vs. pre-exposure). Secondary outcomes, including core temperature area under the curve, peak and end-exposure heart rate, fluid consumption, and thermal discomfort, were also reduced significantly with fan use. Despite these improvements, fan use did not completely ameliorate heat-induced physiological strain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings indicate that while ceiling fans significantly reduce heat-related physiological strain under the conditions tested, they are not wholly efficacious as standalone cooling solutions. A combined “fan-first” approach, integrating fans with ambient cooling strategies, may enhance heat–health protection in older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> ClinicalTrials.Gov Identifier</h3>\u0000 \u0000 <p>NCT06142890</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"74 1","pages":"200-204"},"PeriodicalIF":4.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appropriateness of Antiplatelets and Anticoagulants Among Older Adults Experiencing Falls","authors":"Lindsay C. Klickstein,&nbsp;Joshua Niznik,&nbsp;Victoria Branham,&nbsp;Hannah George,&nbsp;Michelle L. Meyer,&nbsp;Jan Busby-Whitehead,&nbsp;Kathleen Davenport,&nbsp;Ellen Roberts,&nbsp;Parag Goyal,&nbsp;Elizabeth Goldberg,&nbsp;Martin F. Casey","doi":"10.1111/jgs.70127","DOIUrl":"10.1111/jgs.70127","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Antiplatelet and anticoagulant (collectively called antithrombotics) use remains ubiquitous in older adults due to well-established benefits in treating atherosclerotic and thromboembolic disease. It is unclear whether these benefits outweigh the risk of traumatic hemorrhage in older adults with elevated fall risk. Emergency department (ED) providers are well-positioned to identify opportunities to deprescribe likely inappropriate antithrombotics following an emergency visit for a fall. The objective was to determine the prevalence of likely inappropriate antithrombotic use among older adults on antithrombotics presenting to an ED with a fall.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a secondary analysis of a prospective cohort study of older adults presenting to an ED with a fall enrolled from 2020 to 2021 in a pharmacist-led medication reconciliation program at a southeastern academic ED. We utilized the Medication Appropriateness Index (MAI) to assess antithrombotic appropriateness, categorized: appropriate (MAI = 0), potentially inappropriate (MAI = 1–2), and likely inappropriate (MAI ≥ 3).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>171 out of 514 enrolled patients who presented with a fall to the ED were on an antithrombotic. Their mean age was 81.2 years (std dev 9.2) and 66.1% were female (113/171; 95% CI: 58.6%–72.8%). The median MAI score was 2 (IQR: 2–4). Potentially inappropriate or likely inappropriate use was observed in 82.5% (141/171; 95% CI: 76.0%–87.5%) of participants. Aspirin had the highest prevalence of likely inappropriate use at 60% (59/98; 95% CI: 50%–69%), while P2Y12 inhibitors, warfarin, and direct oral anticoagulants had prevalence of likely inappropriate use at 53% (8/15; 95% CI: 27%–78%), 30% (3/10; 95% CI: 8%–67%), and 29% (21/72; 95% CI: 20%–41%), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was a high prevalence of likely inappropriate antithrombotic use among older adults presenting to the ED with a fall. While aspirin had the highest rate of likely inappropriate use, all antithrombotics had 30% or greater rates of likely inappropriate use. An ED encounter presents a critical opportunity to evaluate the appropriateness of antithrombotic use in patients who have fallen.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3670-3678"},"PeriodicalIF":4.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Dysphagia Services Among Older Adults Hospitalized With Pneumonia in a Large Sample of US Hospitals","authors":"Jordanna S. Sevitz,&nbsp;Meggie Griffin,&nbsp;Nicole Rogus-Pulia,&nbsp;Michael Pulia","doi":"10.1111/jgs.70119","DOIUrl":"10.1111/jgs.70119","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pneumonia is a major cause of morbidity and mortality among older adults, with increased risk for individuals with neurodegenerative conditions. Although dysphagia is a significant risk factor for pneumonia pathogenesis, there is a paucity of data on dysphagia management in patients hospitalized with pneumonia. Therefore, we examined dysphagia service utilization rates and associated clinical factors for older adults hospitalized with pneumonia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We identified community-acquired and aspiration pneumonia (CAP and Asp-PNA) general care hospitalizations among older adults (age ≥ 60) between April 2022 and December 2023 using the Premier Healthcare Database. Factors that influenced utilization of three primary dysphagia services—clinical evaluations, instrumental evaluations (e.g., videofluoroscopy), and therapy—were examined in three generalized linear mixed models with a random effect for hospital and adjusted for patient demographics and hospital characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our sample included 195,782 older adults (51.7% female; 19.3% ND; 15.7% Asp-PNA) across 943 hospitals, and 23.6% received a clinical evaluation, 6.8% an instrumental evaluation, and 11.2% therapy. Generalized linear mixed models of clinical evaluations, instrumental evaluations, and therapy revealed significant associations of Asp-PNA, neurodegenerative disease (ND), and their interaction. The association between Asp-PNA and dysphagia services was greater in the non-ND group (clinical: OR = 9.57; instrumental: OR = 9.67; therapy: OR = 8.66) and attenuated in the ND group (clinical: OR = 5.49; instrumental: OR = 4.66; therapy: OR = 4.20). Similarly, the association between ND and dysphagia services was greater for those with CAP (clinical: OR = 2.85; instrumental: OR = 2.03; therapy: OR = 3.11) and dampened for Asp-PNA (clinical: OR = 1.64; instrumental: OR = 0.98; therapy: OR = 1.50).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dysphagia services were provided to less than one quarter of older adults with pneumonia in our large U.S. cohort, although rates were higher among patients with Asp-PNA and neurodegenerative disease. Future research should focus on using dysphagia screening tools to promote appropriate referrals to dysphagia services for pneumonia patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 11","pages":"3484-3494"},"PeriodicalIF":4.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12581205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mammography Completion by Age Among Women in the Veterans Health Administration","authors":"Linnaea Schuttner,&nbsp;Anders Westanmo,&nbsp;Patrick Hammett,&nbsp;Adam Kaplan,&nbsp;Leah Marcotte","doi":"10.1111/jgs.70117","DOIUrl":"10.1111/jgs.70117","url":null,"abstract":"","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3915-3918"},"PeriodicalIF":4.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caregiver Emotional Wellbeing Is Related to Nursing Home Admissions Among Veterans","authors":"Megan E. Shepherd-Banigan,&nbsp;Zhen Li,&nbsp;Pujan R. Patel,&nbsp;Imari Z. Smith,&nbsp;Jeanie Lo,&nbsp;Nadya T. Majette,&nbsp;Josephine C. Jacobs,&nbsp;Melissa L. Gersten-Harris,&nbsp;Timothy Jobin,&nbsp;Anushka V. Pai,&nbsp;Courtney H. Van Houtven,&nbsp;Katherine E. Miller","doi":"10.1111/jgs.70087","DOIUrl":"10.1111/jgs.70087","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Approximately 14 million US adults require long-term care; most of this care is provided in the community by family caregivers. High intensity care can decrease caregiver wellbeing; caregiver burden is a determinant of nursing home admission. This study extends past research to evaluate the association between caregiver subjective burden, depression, and loneliness and subsequent Veteran nursing home admission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study is a time-to-event analysis of Veteran/caregiver pairs. The sample population (<i>n</i> = 1539) includes Veterans aged 26–102 and their caregivers enrolled in the VA's Program of General Caregiver Supports and Services (PGCSS). PGCSS caregivers participated in a telephone survey to assess self-reported caregiver wellbeing (exposure variables: burden, depression, loneliness). The outcome, time to nursing home visits at 3 and 5 years post-survey, was constructed using Veteran medical records. We examined this relationship using the cumulative incidence function stratifying by levels of caregiver burden and depression as well as covariate-adjusted Cox proportional hazard models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We observed a significantly higher incidence of nursing home admission at the 3-year follow-up for Veterans whose caregivers reported higher burden and depression at baseline. Adjusted Cox models also revealed significantly higher risks of Veteran nursing home entry at the 3-year follow-up when caregivers reported greater depression, burden, and loneliness at baseline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study demonstrates that Veterans were more likely to transition from home-based care to facility-based care within 3 years if their caregivers reported higher rates of burden, depression, and loneliness at baseline. These findings illuminate the importance of support services that improve caregiver emotional wellbeing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 11","pages":"3396-3405"},"PeriodicalIF":4.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From One-Size-Fits All to Person-Centered Care: Rethinking Osteoporosis Screening in Nonagenarians","authors":"Brooke Lubinski,&nbsp;Sarah D. Berry","doi":"10.1111/jgs.70132","DOIUrl":"10.1111/jgs.70132","url":null,"abstract":"<p>Factors to balance when considering osteoporosis screening in nonagenarians.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":"3643-3645"},"PeriodicalIF":4.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Note on Feasibility and Acceptability of a Clinician-Caregiver Co-Designed Dementia Care Intervention for Home-Based Primary Care","authors":"Michael L. Malone","doi":"10.1111/jgs.70106","DOIUrl":"https://doi.org/10.1111/jgs.70106","url":null,"abstract":"","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 12","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Supplemental Nutrition Assistance Program (SNAP) Participation and Cognitive Decline Among Older Americans: A 10-Year Longitudinal Study","authors":"Linlin Da,&nbsp;Zhezheng Jin,&nbsp;Qianhui Xu,&nbsp;Lisa M. Renzi-Hammond,&nbsp;Zhuo Chen,&nbsp;M. Mahmud Khan,&nbsp;Janani Rajbhandari-Thapa,&nbsp;Xi Chen,&nbsp;Bei Wu,&nbsp;Suhang Song","doi":"10.1111/jgs.70122","DOIUrl":"10.1111/jgs.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study examines whether SNAP participation slows age-related cognitive decline among cognitively intact older adults over 10 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study using data from SNAP-eligible participants in the Health and Retirement Study, a nationally representative panel survey of U.S. adults aged 50 years and older. Data was collected biennially from 2010 to 2020, and linear mixed regression models were used to estimate associations between SNAP participation and cognitive decline across different population groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SNAP participation was associated with a slower cognitive decline in global cognition (<i>β</i> = 0.10, 95% CI: 0.05, 0.14, <i>p</i> &lt; 0.001), memory (<i>β</i> = 0.07, 95% CI: 0.03, 0.11, <i>p</i> &lt; 0.001), and executive function (<i>β</i> = 0.03, 95% CI: 0.01, 0.04, <i>p</i> = 0.004). A significant three-way interaction among SNAP participation, race/ethnicity, and time indicated a slightly faster decline in global cognition among Non-Hispanic Black and Hispanic SNAP users.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>SNAP participation may help slow age-related cognitive decline. However, the benefits of SNAP vary across different population groups. Further research is warranted to explore the underlying mechanisms and to design interventions that can maximize the benefits of SNAP in improving cognitive decline.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 11","pages":"3464-3474"},"PeriodicalIF":4.5,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://agsjournals.onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145139804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}