Pub Date : 2023-12-01DOI: 10.21608/jesp.2023.331727
Nagah Al-Maroug, Mamdouh Nassar, Mohamed Elshazly, Eman Abd Elfattah, Dina H. Abd El-Monem
Desert Locust, Schistocerca gregaria (Forskål), is one of the important insect pests worldwide. Chemical insecticides proved effective in controlling these locust, but with bad ecosystem impact. This study evaluated the temperature stress on biorational insecticides against Schistocer ca gregaria . Newly moulted 5 th instar nymphs of the desert locust were feed on clover leaves treated with LC 50 of Azadirachtin, Rotenone, Sabadilla and Limonene. Also, anti-hormonal effects of Precocene II showed decrease in protein; carbohydrate and lipid of haemolymph contents after 24hrs treatment of 5 th nymph instar with these biorational insecticides. The higher LC 50 was 3.4 obtained after treating 5 th nymphal instar with azadirachtin, lower LC 50 was 4.2 caused by lim-onene with LC 90 of 15.2 & 28.2% respectively. These biorational insecticides affected protein, lipid and carbohydrate of 5 th nymphal ones, added by temperature marked stress. Supernumerary (extramoulted) nymph emerged after treating 5 th nymph instar with Precocene II. Precocene II caused nymph malformations at high concentration (33.3%; 1000ppm) and at low concentration (14.2%; 50ppm), and blocked adult emergency with increased concentrations.
{"title":"TEMPERATURE STRESS EFFECT ON THE DESERT LOCUST, SCHISTOCERCA GREGARIA USING BIORATIONAL COMPOUNDS","authors":"Nagah Al-Maroug, Mamdouh Nassar, Mohamed Elshazly, Eman Abd Elfattah, Dina H. Abd El-Monem","doi":"10.21608/jesp.2023.331727","DOIUrl":"https://doi.org/10.21608/jesp.2023.331727","url":null,"abstract":"Desert Locust, Schistocerca gregaria (Forskål), is one of the important insect pests worldwide. Chemical insecticides proved effective in controlling these locust, but with bad ecosystem impact. This study evaluated the temperature stress on biorational insecticides against Schistocer ca gregaria . Newly moulted 5 th instar nymphs of the desert locust were feed on clover leaves treated with LC 50 of Azadirachtin, Rotenone, Sabadilla and Limonene. Also, anti-hormonal effects of Precocene II showed decrease in protein; carbohydrate and lipid of haemolymph contents after 24hrs treatment of 5 th nymph instar with these biorational insecticides. The higher LC 50 was 3.4 obtained after treating 5 th nymphal instar with azadirachtin, lower LC 50 was 4.2 caused by lim-onene with LC 90 of 15.2 & 28.2% respectively. These biorational insecticides affected protein, lipid and carbohydrate of 5 th nymphal ones, added by temperature marked stress. Supernumerary (extramoulted) nymph emerged after treating 5 th nymph instar with Precocene II. Precocene II caused nymph malformations at high concentration (33.3%; 1000ppm) and at low concentration (14.2%; 50ppm), and blocked adult emergency with increased concentrations.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312180
Abir Elfiky, Sherif Elfeel, Shorouk Ahmed, May Kataket, T. Morsy
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{"title":"SAFETY OF BEE VENOM PREPARATION FOR MARKETING STRATEGY","authors":"Abir Elfiky, Sherif Elfeel, Shorouk Ahmed, May Kataket, T. Morsy","doi":"10.21608/jesp.2023.312180","DOIUrl":"https://doi.org/10.21608/jesp.2023.312180","url":null,"abstract":".","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80960458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312188
T. Morsy, A. Abou-elmagd, A. Mousa
Giardiasis is a protozoan flagellated zoonotic parasite, causing diarrheal disease caused by G. duodenalis person or animal has been infected with Giardia , the parasite lives in the intestines and is passed in stool (poop). It causes mild or severe diarrhea, gas, stomach cramps, nausea (a feeling of stomach upset), or dehydration (body water loss causes weakness of dizziness). Some people experience no symptoms at all. Cysts once pass are inf-ective, spreads easily and can spread from person to person or through contaminated water, food, surfaces, or objects. Giardiasis shares some pathogens some or less the clinical manifestations.
{"title":"ZOONOTIC GIARDIASIS AND ITS COMPLICATIONS: A REVIEW ARTICLE","authors":"T. Morsy, A. Abou-elmagd, A. Mousa","doi":"10.21608/jesp.2023.312188","DOIUrl":"https://doi.org/10.21608/jesp.2023.312188","url":null,"abstract":"Giardiasis is a protozoan flagellated zoonotic parasite, causing diarrheal disease caused by G. duodenalis person or animal has been infected with Giardia , the parasite lives in the intestines and is passed in stool (poop). It causes mild or severe diarrhea, gas, stomach cramps, nausea (a feeling of stomach upset), or dehydration (body water loss causes weakness of dizziness). Some people experience no symptoms at all. Cysts once pass are inf-ective, spreads easily and can spread from person to person or through contaminated water, food, surfaces, or objects. Giardiasis shares some pathogens some or less the clinical manifestations.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86118773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312121
Suzan EL- SHAHAT, Abeer Abdallah
Polio or poliomyelitis was around since the ancient Egyptian times as a disabling and life-threatening disease caused by the poliovirus, which is very contagious and spreads from person-to-person contact. About 25% with poliovirus infection will have flu-like symptoms including sore throat, fever, tiredness, nausea, headache, and stomach pain, usually last 2 to 5 days that went away on their own. The non-polio enteroviruses that cause meningitis are transmitted fecal-orally, which live in human gastro-intestinal tract, and are shed in the feces as very stable in the environment and can live outside human body for days. There is no cure for polio. Paral-ysis is the most severe symptom associated with poliovirus because it can lead to permanent disability and death. Polio vaccine is the best way to protect against polio.
{"title":"NURSING CARE AND POLIOVIRUS VACCINATION PROTOCOL","authors":"Suzan EL- SHAHAT, Abeer Abdallah","doi":"10.21608/jesp.2023.312121","DOIUrl":"https://doi.org/10.21608/jesp.2023.312121","url":null,"abstract":"Polio or poliomyelitis was around since the ancient Egyptian times as a disabling and life-threatening disease caused by the poliovirus, which is very contagious and spreads from person-to-person contact. About 25% with poliovirus infection will have flu-like symptoms including sore throat, fever, tiredness, nausea, headache, and stomach pain, usually last 2 to 5 days that went away on their own. The non-polio enteroviruses that cause meningitis are transmitted fecal-orally, which live in human gastro-intestinal tract, and are shed in the feces as very stable in the environment and can live outside human body for days. There is no cure for polio. Paral-ysis is the most severe symptom associated with poliovirus because it can lead to permanent disability and death. Polio vaccine is the best way to protect against polio.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86431174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312248
{"title":"Index","authors":"","doi":"10.21608/jesp.2023.312248","DOIUrl":"https://doi.org/10.21608/jesp.2023.312248","url":null,"abstract":"","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80837958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312183
S. Oshiba, G. Sadek, Dina Allam, Tahany AL-ATTAR
One of the most significant opportunistic parasites causing serious infections in humans is Toxoplasma gondii ( T. gondii ). Lack of maximally effective therapeutic drugs for chronic tox-oplasmosis necessitates the search for a reliable and safe toxoplasmosis therapy. This study evaluated, compared, and contrasts the curative and preventative effects of probiotics on mice infected with the ME49 strain of T. gondii , as well as to contrast these effects with those of spiramycin. Probiotic effects were assessed using research in parasitology, histopathology, immunology, and immunohistochemistry. The results showed that probiotics were more helpful when administered as a preventative measure than when provided as a treatment for toxo-plasmosis. Toxoplasma gondii cyst counts in the brain were successfully decreased by probiotics. The inflammation in the heart, eyes, and brain also lessened as a result. Besides, it led to a rise in interleukin-10 (IL-10) and a fall in Interferon-gamma (IFN-brain, heart, and eyes, it also reduced the expression of cluster of differentiation 3 (CD3) and Caspase3. It was less effective than spiramycin, nevertheless, as a therapy.
{"title":"AN EXPERIMENTAL STUDY OF PROTECTIVE AND THERAPEUTIC EFFECTS OF PROBIOTICS ON INFECTION BY TOXOPLASMA GONDII","authors":"S. Oshiba, G. Sadek, Dina Allam, Tahany AL-ATTAR","doi":"10.21608/jesp.2023.312183","DOIUrl":"https://doi.org/10.21608/jesp.2023.312183","url":null,"abstract":"One of the most significant opportunistic parasites causing serious infections in humans is Toxoplasma gondii ( T. gondii ). Lack of maximally effective therapeutic drugs for chronic tox-oplasmosis necessitates the search for a reliable and safe toxoplasmosis therapy. This study evaluated, compared, and contrasts the curative and preventative effects of probiotics on mice infected with the ME49 strain of T. gondii , as well as to contrast these effects with those of spiramycin. Probiotic effects were assessed using research in parasitology, histopathology, immunology, and immunohistochemistry. The results showed that probiotics were more helpful when administered as a preventative measure than when provided as a treatment for toxo-plasmosis. Toxoplasma gondii cyst counts in the brain were successfully decreased by probiotics. The inflammation in the heart, eyes, and brain also lessened as a result. Besides, it led to a rise in interleukin-10 (IL-10) and a fall in Interferon-gamma (IFN-brain, heart, and eyes, it also reduced the expression of cluster of differentiation 3 (CD3) and Caspase3. It was less effective than spiramycin, nevertheless, as a therapy.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82489423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312164
Tahany AL-ATTAR, A. Matar, Mona A. Kora, M. Faheem
Cryptosporidiosis is a major zoonotic health problem especially in immunocompromised hosts. The current study investigated the effect of Daflon (DFL) as an alternative therapy or combined with Nitazoxanide (NTZ) against cryptosporidiosis in immuno-competent and immuno-suppres-sed mice. Fifty mice were divided into two major groups: GI included immuno-competent mice and GII included drug-induced immuno-suppressed mice. Each group of five mice was subdivided equally into five subgroups. Mice subgroups were either in GI or GII as follows: A: Control negative neither infected nor treated, B: Control positive C. parvum infected but not treated, C: C. parvum infected NTZ treated, D: C. parvum infected and DFL treated & E: C. parvum infected combined treated (NTZ+ DFL). Drug efficacy was done by parasitological, biochemical, histopathological, and immunohistochemical analysis. All drugs significantly reduced oocysts' number compared to their counterparts infected mice. There was an increase in SOD and a decrease in MDA serum levels in mice received combined treatment. Histopathologically, all tissues in mice received combined treatment more or less retained their normal architecture. Also, iNOS expression in treated groups turned into weak cytoplasmic expression in all tissues with the best effect in mice received combined treatment.
{"title":"DAFLON AS A NEW DRUG IN TREATING MURINE EXPERIMENTAL CRYPTOSPORIDIOSIS","authors":"Tahany AL-ATTAR, A. Matar, Mona A. Kora, M. Faheem","doi":"10.21608/jesp.2023.312164","DOIUrl":"https://doi.org/10.21608/jesp.2023.312164","url":null,"abstract":"Cryptosporidiosis is a major zoonotic health problem especially in immunocompromised hosts. The current study investigated the effect of Daflon (DFL) as an alternative therapy or combined with Nitazoxanide (NTZ) against cryptosporidiosis in immuno-competent and immuno-suppres-sed mice. Fifty mice were divided into two major groups: GI included immuno-competent mice and GII included drug-induced immuno-suppressed mice. Each group of five mice was subdivided equally into five subgroups. Mice subgroups were either in GI or GII as follows: A: Control negative neither infected nor treated, B: Control positive C. parvum infected but not treated, C: C. parvum infected NTZ treated, D: C. parvum infected and DFL treated & E: C. parvum infected combined treated (NTZ+ DFL). Drug efficacy was done by parasitological, biochemical, histopathological, and immunohistochemical analysis. All drugs significantly reduced oocysts' number compared to their counterparts infected mice. There was an increase in SOD and a decrease in MDA serum levels in mice received combined treatment. Histopathologically, all tissues in mice received combined treatment more or less retained their normal architecture. Also, iNOS expression in treated groups turned into weak cytoplasmic expression in all tissues with the best effect in mice received combined treatment.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91399793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312133
Heba Aboelela, S. Rashed, M. Nasr, O. Hammam, E. Elsayed, A. Ali
Trichinella spiralis is one of the most widespread zoonotic parasitic nematodes in the world. There is an increasing interest in developing new safe and effective anthelminthic herbal drug against T. spiralis . This study assessed the effect of curcumin (bioactive compound of C. longa ) in treatment of T. spiralis infected mice compared with albendazole. Seventy-five albino mice were classified into four groups. GI: Non-infected control, GII: Infected non-treated control, GIII: Treated early 3 rd dpi by albendazole alone, curcumin alone, and combination of albendazole & curcumin, and GIV: Treated on 31 st dpi by the same drugs. Mice were sacrificed on the 7 th dpi for intestinal phase assessment and on the 49 th dpi for muscle assessment. Treatment efficiency was assessed by parasitological and histopathological examinations. The results showed a significant decrease in intestinal adults ' count in all treated groups compared to non-treated cont rolones. Reduction rates of the intestinal phase were 92.87% in albendazole & curcumin treated group followed by 87.58% in albendazole treated group and 62.93% in curcumin treated group. There was also significant decrease in muscle larvae count compared to positive control ones by reduction rates of 84.03%, 70.38% & 44.96% for albendazole &curcumin, albendazole alone and curcumin alone respectively. The histopathological results showed improvement in intestinal and muscular architecture in all treated groups compared to positive control one, particularly in combined albendazole & curcumin treated group.
{"title":"CURCUMIN IN TREATMENT OF EXPERIMENTAL TRICHINOSIS","authors":"Heba Aboelela, S. Rashed, M. Nasr, O. Hammam, E. Elsayed, A. Ali","doi":"10.21608/jesp.2023.312133","DOIUrl":"https://doi.org/10.21608/jesp.2023.312133","url":null,"abstract":"Trichinella spiralis is one of the most widespread zoonotic parasitic nematodes in the world. There is an increasing interest in developing new safe and effective anthelminthic herbal drug against T. spiralis . This study assessed the effect of curcumin (bioactive compound of C. longa ) in treatment of T. spiralis infected mice compared with albendazole. Seventy-five albino mice were classified into four groups. GI: Non-infected control, GII: Infected non-treated control, GIII: Treated early 3 rd dpi by albendazole alone, curcumin alone, and combination of albendazole & curcumin, and GIV: Treated on 31 st dpi by the same drugs. Mice were sacrificed on the 7 th dpi for intestinal phase assessment and on the 49 th dpi for muscle assessment. Treatment efficiency was assessed by parasitological and histopathological examinations. The results showed a significant decrease in intestinal adults ' count in all treated groups compared to non-treated cont rolones. Reduction rates of the intestinal phase were 92.87% in albendazole & curcumin treated group followed by 87.58% in albendazole treated group and 62.93% in curcumin treated group. There was also significant decrease in muscle larvae count compared to positive control ones by reduction rates of 84.03%, 70.38% & 44.96% for albendazole &curcumin, albendazole alone and curcumin alone respectively. The histopathological results showed improvement in intestinal and muscular architecture in all treated groups compared to positive control one, particularly in combined albendazole & curcumin treated group.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75696170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312097
A. Hafez, A. Mohamed, M. Shakra
Schistosomiasis is blood-dwelling parasites of the genus Schistosoma , mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel ® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen ® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice.
{"title":"TAMOXIFEN VERSUS PRAZIQUANTEL IN TREATING SCHISTOSOMIASIS MANSONI IN EXPERIMENTAL INFECTED ALBINO MICE","authors":"A. Hafez, A. Mohamed, M. Shakra","doi":"10.21608/jesp.2023.312097","DOIUrl":"https://doi.org/10.21608/jesp.2023.312097","url":null,"abstract":"Schistosomiasis is blood-dwelling parasites of the genus Schistosoma , mainly S. mansoni, S. japonicum and S. haematobium. Praziquantel ® (PZQ) is the drug of choice for treatment but, its efficacy decreased as drug resistant strains emerged due to widespread usages. This study assessed the in-vivo anti-schistosomal effects of Tamoxifen ® (TAM) compared to praziquantel on experimental S. mansoni-infected mice regarding worm burden, liver enzymes status, cytokines change, histopathological study and the activities of some antioxidants. Mice were infected by ~80±10 cercariae followed by a single oral dose with either praziquantel or tamoxifen 42 days post-infection. The treated mice showed a reduction in worm burden, a decrease in egg load in liver and intestine, a decrease in levels of AST, ALT, interferon-gamma, interleukin 4, and interleukin 10 but, with a significant activities increase of superoxide dismutase (SOD), glutathione-s-transferase (GST), glutathione peroxidase (GPx) and Catalase (CAT) and decrease in granuloma size than infected non-treated mice.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83710733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-01DOI: 10.21608/jesp.2023.312096
M. Behairy, Mahmoud Zaki, A. Sharawy, Tamer El Said, R. Samir
This study evaluated the hypothesis of a possible association between hyperparathyroidism and the presence of hepatic steatosis and fibrosis among prevalent hemodialysis (HD) patients and evaluated the possible risk factors of non-alcoholic fatty liver disease (NAFLD) among those patients. This is a case-control study that included HD patients divided into GI: (30) HD patients with NAFLD, GII: (25) HD patients without NAFLD as well as GIII: (30) healthy volunteers as a control. Viral hepatitis, Diabetes mellitus, recent hepatobiliary surgery, ascites, active infection, malignancy, alcohol, or drugs induce hepatic steatosis were excluded. Complete blood count, Iron profile, lipid profile, liver function tests, C-reactive protein (CRP) titer, intact parathyroid hormone (iPTH), and other routine chemistry tests were done. Transient elastography Fibroscan ® to assess controlled attenuation parameter (CAP) to detect liver steatosis grades and liver stiffness measurement was done. Results: Mean ±SD values of CAP of liver steatosis (263.7±52.7, 181.3±23, 210.8±33.7) (dB/m) in GI, GII & control group respectively (P <0.001). Post-Hoc analysis revealed a significant statistical difference between G I and II as regards ALT, AST, Bilirubin level and serum albumin, CRP titer, and lipid profile. In HD patients' studied groups, the CAP value of liver steatosis was significantly correlated to BMI, ALT, AST, Cholesterol, LDL, TG, & CRP Titer, but not correlated to PTH or other parameters. In GIII, there was a significant correlation between the measured CAP value of liver steatosis and BMI, iPTH, CRP titer, ALT, AST, cholesterol, LDL, and a negative correlation between HDL and CAP value. Liver stiffness/fibrosis was in 18 (60.0%), HD patients versus 8 (32%) patients in GII. Analysis showed a significant difference between GI & GII and between GI and GIII regarding the presence of liver fibrosis.
{"title":"RELATIONSHIP BETWEEN PARATHYROID HORMONE LEVEL AND HEPATIC STEATOSIS DEGREE BY FIBROSCAN AMONG PREVALENT HEMODIALYSIS PATIENTS","authors":"M. Behairy, Mahmoud Zaki, A. Sharawy, Tamer El Said, R. Samir","doi":"10.21608/jesp.2023.312096","DOIUrl":"https://doi.org/10.21608/jesp.2023.312096","url":null,"abstract":"This study evaluated the hypothesis of a possible association between hyperparathyroidism and the presence of hepatic steatosis and fibrosis among prevalent hemodialysis (HD) patients and evaluated the possible risk factors of non-alcoholic fatty liver disease (NAFLD) among those patients. This is a case-control study that included HD patients divided into GI: (30) HD patients with NAFLD, GII: (25) HD patients without NAFLD as well as GIII: (30) healthy volunteers as a control. Viral hepatitis, Diabetes mellitus, recent hepatobiliary surgery, ascites, active infection, malignancy, alcohol, or drugs induce hepatic steatosis were excluded. Complete blood count, Iron profile, lipid profile, liver function tests, C-reactive protein (CRP) titer, intact parathyroid hormone (iPTH), and other routine chemistry tests were done. Transient elastography Fibroscan ® to assess controlled attenuation parameter (CAP) to detect liver steatosis grades and liver stiffness measurement was done. Results: Mean ±SD values of CAP of liver steatosis (263.7±52.7, 181.3±23, 210.8±33.7) (dB/m) in GI, GII & control group respectively (P <0.001). Post-Hoc analysis revealed a significant statistical difference between G I and II as regards ALT, AST, Bilirubin level and serum albumin, CRP titer, and lipid profile. In HD patients' studied groups, the CAP value of liver steatosis was significantly correlated to BMI, ALT, AST, Cholesterol, LDL, TG, & CRP Titer, but not correlated to PTH or other parameters. In GIII, there was a significant correlation between the measured CAP value of liver steatosis and BMI, iPTH, CRP titer, ALT, AST, cholesterol, LDL, and a negative correlation between HDL and CAP value. Liver stiffness/fibrosis was in 18 (60.0%), HD patients versus 8 (32%) patients in GII. Analysis showed a significant difference between GI & GII and between GI and GIII regarding the presence of liver fibrosis.","PeriodicalId":17289,"journal":{"name":"Journal of the Egyptian Society of Parasitology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87316103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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