Background Coronavirus disease 2019 (COVID-19)-infected individuals can be asymptomatic or have mild symptoms. Cutaneous affection with COVID-19 is a unique presentation. Objective To describe the clinical presentations of skin affection in COVID-19-confirmed patients attending a dermatology outpatient clinic. Patients and methods A retrospective analysis was performed on the medical records of a single dermatology outpatient clinic described cutaneous presentations associated with COVID-19 infection in patients attending in the period from October 2020 to December 2020. Results A total of 44 COVID-19-positive patients presented with skin affection. The most common presentation was urticaria (24, 54.5%), followed by herpes simplex (seven, 15.9%), herpes zoster (four, 9.1%), papulosquamous (three, 6.9%), papulovesicular (two, 4.6%), acral lesions (two, 4.6%), leukocytoclastic vasculitis (one, 2.3%), and Kawasaki-like disease (one, 2.3%). Nine (20.5%) patients had asymptomatic COVID-19 infection, 24 (54.5%) patients had mild COVID-19, nine (20.5%) patients had moderate COVID-19, and two (4.5%) patients had severe COVID-19. Among patients with COVID-19 symptoms (35, 79.5%), seven (20%) patients presented with the cutaneous presentation before the onset of COVID-19 symptoms, whereas in the rest of the patients, cutaneous affection was simultaneous with COVID-19 symptoms (28, 80%). Conclusion Cutaneous affection can be the striking presentation for COVID-19 requiring dermatological consultation. Awareness and early recognition of skin affection associated with COVID-19 are required. Dermatologists should follow all of the precautions and use adequate personal protective equipment during their outpatient practices. Skin presentations, notably urticaria, can precede the systemic and respiratory symptoms of COVID-19. Severe mucocutaneous herpes simplex can occur with COVID-19 and require prompt medical treatment.
{"title":"Can skin affection be a clue to COVID-19? results from a dermatology outpatient clinic in Egypt","authors":"Mona El-Kalioby, P. Mostafa, LobnaG. Alieldin","doi":"10.4103/jewd.jewd_63_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_63_21","url":null,"abstract":"Background Coronavirus disease 2019 (COVID-19)-infected individuals can be asymptomatic or have mild symptoms. Cutaneous affection with COVID-19 is a unique presentation. Objective To describe the clinical presentations of skin affection in COVID-19-confirmed patients attending a dermatology outpatient clinic. Patients and methods A retrospective analysis was performed on the medical records of a single dermatology outpatient clinic described cutaneous presentations associated with COVID-19 infection in patients attending in the period from October 2020 to December 2020. Results A total of 44 COVID-19-positive patients presented with skin affection. The most common presentation was urticaria (24, 54.5%), followed by herpes simplex (seven, 15.9%), herpes zoster (four, 9.1%), papulosquamous (three, 6.9%), papulovesicular (two, 4.6%), acral lesions (two, 4.6%), leukocytoclastic vasculitis (one, 2.3%), and Kawasaki-like disease (one, 2.3%). Nine (20.5%) patients had asymptomatic COVID-19 infection, 24 (54.5%) patients had mild COVID-19, nine (20.5%) patients had moderate COVID-19, and two (4.5%) patients had severe COVID-19. Among patients with COVID-19 symptoms (35, 79.5%), seven (20%) patients presented with the cutaneous presentation before the onset of COVID-19 symptoms, whereas in the rest of the patients, cutaneous affection was simultaneous with COVID-19 symptoms (28, 80%). Conclusion Cutaneous affection can be the striking presentation for COVID-19 requiring dermatological consultation. Awareness and early recognition of skin affection associated with COVID-19 are required. Dermatologists should follow all of the precautions and use adequate personal protective equipment during their outpatient practices. Skin presentations, notably urticaria, can precede the systemic and respiratory symptoms of COVID-19. Severe mucocutaneous herpes simplex can occur with COVID-19 and require prompt medical treatment.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"108 - 114"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47421183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. El-Komy, Sara Aboelmagd, Haidy Khalil, R. Abdelrahman, N. Bedair
Background Onychomycosis among patients with nail psoriasis is being increasingly reported in the literature. When the two conditions coexist in the same nail, it is usually difficult to clinically detect the fungal nail affection. Objective To study the value of dermoscopy in detecting distal and lateral subungual onychomycosis among patients with nail psoriasis. Patients and methods Fifty psoriasis patients with nail changes were subjected to full history and clinical examination, including targeted Nail Psoriasis Severity Index calculation, dermoscopic examination and nail scrapping for fungal culture on Sabouraud dextrose agar, and dermatophyte (DM) test medium. Results Twelve (24%) of the 50 patients recruited showed a positive mycological growth on culture. Nondermatophyte molds and DM were isolated from 16 and 8% of patients, respectively. Nail psoriasis severity was not affected by fungal growth on culture and no significant relation could be detected between culture results and nail dermoscopic findings. Conclusion Specific dermoscopic signs of distal and lateral subungual onychomycosis do not appear to be evident in severely dystrophic psoriatic nails even when culture results show growth for DM and/or nondermatophyte molds.
{"title":"Limitations of dermoscopy in detecting distal and lateral subungual onychomycosis among patients with severely dystrophic nail psoriasis","authors":"M. El-Komy, Sara Aboelmagd, Haidy Khalil, R. Abdelrahman, N. Bedair","doi":"10.4103/jewd.jewd_43_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_43_21","url":null,"abstract":"Background Onychomycosis among patients with nail psoriasis is being increasingly reported in the literature. When the two conditions coexist in the same nail, it is usually difficult to clinically detect the fungal nail affection. Objective To study the value of dermoscopy in detecting distal and lateral subungual onychomycosis among patients with nail psoriasis. Patients and methods Fifty psoriasis patients with nail changes were subjected to full history and clinical examination, including targeted Nail Psoriasis Severity Index calculation, dermoscopic examination and nail scrapping for fungal culture on Sabouraud dextrose agar, and dermatophyte (DM) test medium. Results Twelve (24%) of the 50 patients recruited showed a positive mycological growth on culture. Nondermatophyte molds and DM were isolated from 16 and 8% of patients, respectively. Nail psoriasis severity was not affected by fungal growth on culture and no significant relation could be detected between culture results and nail dermoscopic findings. Conclusion Specific dermoscopic signs of distal and lateral subungual onychomycosis do not appear to be evident in severely dystrophic psoriatic nails even when culture results show growth for DM and/or nondermatophyte molds.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"31 - 38"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48781612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dwi Murtiastutik, C. Prakoeswa, I. Tantular, M. Listiawan, A. Hidayati, Evy Ervianti, Lunardi Bintanjoyo
Background Oral candidiasis (OC) is an oral mucosal disorder due to Candida genus. Its predisposing factor among patients with HIV/AIDS is mainly decreasing CD4 count. OC is commonly caused by Candida albicans. As CD4 decreases, the shift to C. non-albicans has been observed. Objective To evaluate the association of Candida species with CD4 count and clinical features in HIV/AIDS patients with OC. Patients and methods This is a cross-sectional study. A total of 114 oral rinse solution samples from HIV/AIDS patients with OC were collected. Candida species identification was done by culture in Chromagar followed by VITEK 2. The association of Candida species with CD4 count and clinical features was analyzed using Pearson’s χ2 and Kruskal–Wallis tests. Results There was growth of 149 isolates in culture from 114 patients. C. albicans was found in 104 (69.7%) isolates. Candida non-albicans were found in 45 (30.3%) isolates, namely Candida krusei in 22 (14.85%), Candida glabrata in 12 (8.1%), Candida tropicalis in six (4.05%), Candida dubliniensis in two (1.3%), Candida parapsilosis in two (1.3%), and Candida lipolytica in one (0.7%) isolate. Candida species was significantly associated with clinical types, episode types, pain on swallowing, CD4 count, and antiretroviral (ARV) use among all patients. Conclusion Among HIV/AIDS patients with OC, growth of C. albicans only was more common in higher CD4 count, while mixed growth of C. albicans and C. non-albicans was more common in lower CD4 count. Clinical features associated with growth of C. albicans only were pseudomembranous type, recurrent OC, absence of pain on swallowing, and patients on ARV, whereas those associated with mixed growth of C. albicans and C. non-albicans were cheilitis type, first-episode OC, presence of pain on swallowing, and ARV-naive patients.
{"title":"Association between etiologic species with CD4 count and clinical features of oral candidiasis among HIV/AIDS patients","authors":"Dwi Murtiastutik, C. Prakoeswa, I. Tantular, M. Listiawan, A. Hidayati, Evy Ervianti, Lunardi Bintanjoyo","doi":"10.4103/jewd.jewd_44_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_44_21","url":null,"abstract":"Background Oral candidiasis (OC) is an oral mucosal disorder due to Candida genus. Its predisposing factor among patients with HIV/AIDS is mainly decreasing CD4 count. OC is commonly caused by Candida albicans. As CD4 decreases, the shift to C. non-albicans has been observed. Objective To evaluate the association of Candida species with CD4 count and clinical features in HIV/AIDS patients with OC. Patients and methods This is a cross-sectional study. A total of 114 oral rinse solution samples from HIV/AIDS patients with OC were collected. Candida species identification was done by culture in Chromagar followed by VITEK 2. The association of Candida species with CD4 count and clinical features was analyzed using Pearson’s χ2 and Kruskal–Wallis tests. Results There was growth of 149 isolates in culture from 114 patients. C. albicans was found in 104 (69.7%) isolates. Candida non-albicans were found in 45 (30.3%) isolates, namely Candida krusei in 22 (14.85%), Candida glabrata in 12 (8.1%), Candida tropicalis in six (4.05%), Candida dubliniensis in two (1.3%), Candida parapsilosis in two (1.3%), and Candida lipolytica in one (0.7%) isolate. Candida species was significantly associated with clinical types, episode types, pain on swallowing, CD4 count, and antiretroviral (ARV) use among all patients. Conclusion Among HIV/AIDS patients with OC, growth of C. albicans only was more common in higher CD4 count, while mixed growth of C. albicans and C. non-albicans was more common in lower CD4 count. Clinical features associated with growth of C. albicans only were pseudomembranous type, recurrent OC, absence of pain on swallowing, and patients on ARV, whereas those associated with mixed growth of C. albicans and C. non-albicans were cheilitis type, first-episode OC, presence of pain on swallowing, and ARV-naive patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"51 - 57"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49463458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Tawfik, Refaat Mohammed, Ali Sobhy, A. Shaltout
Background Dermatomycosis affects millions of people worldwide; the availability of data on the prevalence of superficial fungal infections and some associated epidemiological factors in our region is little. Objective To compare conventional and molecular methods to characterize some fungal species causing human mycotic infection. Patients and methods The present cross-sectional study of fungal skin diseases was done on 100 patients. Skin scrapings and nail cuttings were subjected to direct microscopic examination using potassium hydroxide and lactophenol cotton blue, followed by culturing on Sabouraud’ dextrose agar. HiCrome agar was used for characterization of Candida species. Molecular diagnosis of some fungal isolates was performed by sequencing the ribosomal DNA internal transcribed spacer region. Results Tinea capitis was the commonest clinical presentation in 48% of cases, followed by tinea corporis 20% and tinea faciei 13%. Fungi were demonstrated in 88% of cases by direct microscopy and/or culture. Direct microscopy was positive in 51% of cases. A higher percentage of positivity 77% was obtained from samples cultured on Sabouraud’ dextrose agar. Dermatophytes were isolated from patients who complained of tinea capitis and tinea corporis (75 and 70%, respectively). Comparing molecular with conventional results, it was found that molecular identification was confirmatory to conventional results, except in two isolates: Chrysosporium lobatum was previously diagnosed as Chrysosporium tropicum and Trichophyton interdigitale was previously diagnosed as Trichophyton mentagrophytes by conventional methods. Conclusion Trichophyton violaceum and Microsporum canis were the main etiologic agents of tinea capitis (45.8 and 27%, respectively). Epidermophyton floccosum was only isolated from four cases of tinea corporis and one of the tinea cruris. Candida species were the main causal agents of onychomycosis. Acremonium spinosum and C. lobatum appeared in this study as new etiologic agents of nail infections. Molecular identification is confirmatory to conventional results, but it is expensive and faces some difficulties, in our country, its use is encouraged to identify dermatophytes in atypical isolates.
{"title":"Conventional and molecular diagnostics for detection of causative fungi in clinical samples of human dermatomycosis","authors":"K. Tawfik, Refaat Mohammed, Ali Sobhy, A. Shaltout","doi":"10.4103/jewd.jewd_38_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_38_21","url":null,"abstract":"Background Dermatomycosis affects millions of people worldwide; the availability of data on the prevalence of superficial fungal infections and some associated epidemiological factors in our region is little. Objective To compare conventional and molecular methods to characterize some fungal species causing human mycotic infection. Patients and methods The present cross-sectional study of fungal skin diseases was done on 100 patients. Skin scrapings and nail cuttings were subjected to direct microscopic examination using potassium hydroxide and lactophenol cotton blue, followed by culturing on Sabouraud’ dextrose agar. HiCrome agar was used for characterization of Candida species. Molecular diagnosis of some fungal isolates was performed by sequencing the ribosomal DNA internal transcribed spacer region. Results Tinea capitis was the commonest clinical presentation in 48% of cases, followed by tinea corporis 20% and tinea faciei 13%. Fungi were demonstrated in 88% of cases by direct microscopy and/or culture. Direct microscopy was positive in 51% of cases. A higher percentage of positivity 77% was obtained from samples cultured on Sabouraud’ dextrose agar. Dermatophytes were isolated from patients who complained of tinea capitis and tinea corporis (75 and 70%, respectively). Comparing molecular with conventional results, it was found that molecular identification was confirmatory to conventional results, except in two isolates: Chrysosporium lobatum was previously diagnosed as Chrysosporium tropicum and Trichophyton interdigitale was previously diagnosed as Trichophyton mentagrophytes by conventional methods. Conclusion Trichophyton violaceum and Microsporum canis were the main etiologic agents of tinea capitis (45.8 and 27%, respectively). Epidermophyton floccosum was only isolated from four cases of tinea corporis and one of the tinea cruris. Candida species were the main causal agents of onychomycosis. Acremonium spinosum and C. lobatum appeared in this study as new etiologic agents of nail infections. Molecular identification is confirmatory to conventional results, but it is expensive and faces some difficulties, in our country, its use is encouraged to identify dermatophytes in atypical isolates.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"21 - 30"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46840395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Khatri, Pankaj Adhicari, M. Parry, Manjuri Sharma
Background Cutaneous manifestations in chronic kidney disease (CKD) can affect quality of life and can vary across regions, races, and nutritional status of patients. Objective To study the prevalence of mucocutaneous manifestations in patients with CKD and compare between dialysis and nondialysis patients. Patients and methods This was a cross-sectional study from North-East India. A total of 210 patients with CKD were included, with 61 patients in dialysis group and 149 in the nondialysis group. A comprehensive history, detailed examination, and all the relevant investigations were done. Results There was a male predominance in this study, and the mean age was 49.85±12.5 years. Diabetes mellitus (42.9%) was the most common cause of CKD. Cutaneous involvement was seen in 142 (67.61%) patients, with predominance in dialysis patients (60/61) (98.36%) as compared with nondialysis patients (80/149) (55.03%). Xerosis (58.09%) was the most common skin change seen in 122 patients, being more in the dialysis group as compared with the nondialysis group (73.8 vs. 51.7%; P=0.0034). This was followed by pallor (36.19%) of the skin and mucosa. Pruritus (35.23%) was seen in 74 patients, being more in dialysis patients. Cutaneous infections were seen in 57 patients. Absent lunula (14.26%) and half-and-half nail (12.85%) were the most common nail changes. Mucosal changes were seen in 28 (13.33%) patients. Hair changes were seen in 16.67% of patients, with predominant affection in dialysis patients. Conclusion Xerosis, pruritus, skin pallor, absent lunula, xerostomia, macroglossia, and infections were the most common mucocutaneous manifestations in this study. Xerosis, pruritus, absent lunula, and hair changes were more common in dialysis patients.
{"title":"Mucocutaneous manifestations in patients with chronic kidney disease: a cross-sectional hospital-based study from North-East India","authors":"H. Khatri, Pankaj Adhicari, M. Parry, Manjuri Sharma","doi":"10.4103/jewd.jewd_55_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_55_21","url":null,"abstract":"Background Cutaneous manifestations in chronic kidney disease (CKD) can affect quality of life and can vary across regions, races, and nutritional status of patients. Objective To study the prevalence of mucocutaneous manifestations in patients with CKD and compare between dialysis and nondialysis patients. Patients and methods This was a cross-sectional study from North-East India. A total of 210 patients with CKD were included, with 61 patients in dialysis group and 149 in the nondialysis group. A comprehensive history, detailed examination, and all the relevant investigations were done. Results There was a male predominance in this study, and the mean age was 49.85±12.5 years. Diabetes mellitus (42.9%) was the most common cause of CKD. Cutaneous involvement was seen in 142 (67.61%) patients, with predominance in dialysis patients (60/61) (98.36%) as compared with nondialysis patients (80/149) (55.03%). Xerosis (58.09%) was the most common skin change seen in 122 patients, being more in the dialysis group as compared with the nondialysis group (73.8 vs. 51.7%; P=0.0034). This was followed by pallor (36.19%) of the skin and mucosa. Pruritus (35.23%) was seen in 74 patients, being more in dialysis patients. Cutaneous infections were seen in 57 patients. Absent lunula (14.26%) and half-and-half nail (12.85%) were the most common nail changes. Mucosal changes were seen in 28 (13.33%) patients. Hair changes were seen in 16.67% of patients, with predominant affection in dialysis patients. Conclusion Xerosis, pruritus, skin pallor, absent lunula, xerostomia, macroglossia, and infections were the most common mucocutaneous manifestations in this study. Xerosis, pruritus, absent lunula, and hair changes were more common in dialysis patients.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"58 - 65"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48664329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acne occurs in all races and ethnicities. In patients with pigmented skin, acne is very common. As far as the morphology of acne lesions is concerned, no significant differences exist between Caucasian and non-Caucasian skin; however, nodular acne is likely less frequent in patients with pigmented skin. The anatomic distribution of the lesions is similar in all races and ethnicities. Pomade acne is caused by the chronic application of oily products that are used to smooth the hair. It is characterized by more or less numerous closed comedones, with some papules and rare pustules, located on the forehead and temples. A very common and important complication of acne in patients with pigmented skin is postinflammatory hyperpigmentation. It is characterized by brown-to-black macules, of different morphology and size, located mainly on the face. Additional complications of acne in patients with pigmented skin are scars and keloids. The treatment of acne is superimposable in all phototypes. In order to improve tolerability and compliance of topical anti-acne therapy in patients with pigmented skin, it is helpful to begin the treatment with the lowest concentration of the drug, to use a cream or an aqueous gel as vehicle, to apply the drug every other day, with gradual increase to daily use, and to apply frequently a moisturizer. Furthermore, photoprotection is very important.
{"title":"Acne on pigmented skin","authors":"S. Veraldi, A. Faraci, G. Nazzaro, M. Barbareschi","doi":"10.4103/jewd.jewd_39_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_39_21","url":null,"abstract":"Acne occurs in all races and ethnicities. In patients with pigmented skin, acne is very common. As far as the morphology of acne lesions is concerned, no significant differences exist between Caucasian and non-Caucasian skin; however, nodular acne is likely less frequent in patients with pigmented skin. The anatomic distribution of the lesions is similar in all races and ethnicities. Pomade acne is caused by the chronic application of oily products that are used to smooth the hair. It is characterized by more or less numerous closed comedones, with some papules and rare pustules, located on the forehead and temples. A very common and important complication of acne in patients with pigmented skin is postinflammatory hyperpigmentation. It is characterized by brown-to-black macules, of different morphology and size, located mainly on the face. Additional complications of acne in patients with pigmented skin are scars and keloids. The treatment of acne is superimposable in all phototypes. In order to improve tolerability and compliance of topical anti-acne therapy in patients with pigmented skin, it is helpful to begin the treatment with the lowest concentration of the drug, to use a cream or an aqueous gel as vehicle, to apply the drug every other day, with gradual increase to daily use, and to apply frequently a moisturizer. Furthermore, photoprotection is very important.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"1 - 6"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43546663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Nagui, Marwa Saleh, Sherien M. El-Daly, Nohha Khater, D. E. El Sharkawy
Background Exposure to the sun is the main cause of basal cell carcinoma (BCC) development and also the main source of vitamin D in the body. Vitamin D has anticancer activities; however, its role in BCC is debatable. Objective To measure the level of plasma vitamin D, vitamin D-binding protein (VDBP), and vitamin D receptor (VDR) relative expression in BCC patients and healthy controls, in an attempt to evaluate their association with BCC development. Patients and methods Plasma vitamin D and VDBP as well as VDR relative expression levels were measured in 30 BCC patients and 30 healthy controls. VDR relative expression was also measured in nonlesional skin of patients and compared with that of lesional skin. Results Vitamin D, VDBP, and VDR expression levels were statistically significantly lower in BCC patients (16.8±9.65 ng/ml, 275.8±206.7 ng/ml, 0.49±0.35, respectively) than in controls (22.7±11.3 ng/ml, 429.7±248.1 ng/ml, 1.02±0.07, respectively) (P=0.027, 0.12, and 0.001, respectively). In addition, VDR relative expression was statistically significantly lower in BCC tissue than in nonlesional skin of patients (0.644±0.234) (P=0.001). Conclusion Decreased vitamin D, VDBP, and VDR expression levels may be associated with BCC, suggesting a possible role in the pathogenesis of the disease. Correction of vitamin D deficiency via supplementation or topical application of vitamin D analogs may have a role in the prevention or therapy of BCCs that should be evaluated.
{"title":"Evaluation of vitamin D and vitamin D-binding protein levels and vitamin D receptor expression in basal cell carcinoma: a case–control study","authors":"N. Nagui, Marwa Saleh, Sherien M. El-Daly, Nohha Khater, D. E. El Sharkawy","doi":"10.4103/jewd.jewd_33_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_33_21","url":null,"abstract":"Background Exposure to the sun is the main cause of basal cell carcinoma (BCC) development and also the main source of vitamin D in the body. Vitamin D has anticancer activities; however, its role in BCC is debatable. Objective To measure the level of plasma vitamin D, vitamin D-binding protein (VDBP), and vitamin D receptor (VDR) relative expression in BCC patients and healthy controls, in an attempt to evaluate their association with BCC development. Patients and methods Plasma vitamin D and VDBP as well as VDR relative expression levels were measured in 30 BCC patients and 30 healthy controls. VDR relative expression was also measured in nonlesional skin of patients and compared with that of lesional skin. Results Vitamin D, VDBP, and VDR expression levels were statistically significantly lower in BCC patients (16.8±9.65 ng/ml, 275.8±206.7 ng/ml, 0.49±0.35, respectively) than in controls (22.7±11.3 ng/ml, 429.7±248.1 ng/ml, 1.02±0.07, respectively) (P=0.027, 0.12, and 0.001, respectively). In addition, VDR relative expression was statistically significantly lower in BCC tissue than in nonlesional skin of patients (0.644±0.234) (P=0.001). Conclusion Decreased vitamin D, VDBP, and VDR expression levels may be associated with BCC, suggesting a possible role in the pathogenesis of the disease. Correction of vitamin D deficiency via supplementation or topical application of vitamin D analogs may have a role in the prevention or therapy of BCCs that should be evaluated.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"14 - 20"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47328604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Anbar, M. Atwa, Rasha T A Abdel-Aziz, R. Hegazy, Sarah Ibrahim, Rabab El Genedy, A. Afify, Mohammed Anbar, C. Farid
Background Visual recognition of alteration in the skin color depends upon the contrast between altered areas and their surrounding background color. The maximum contrast in vitiligo exists in dark-complexioned patients between depigmented white patches and unaffected background dark skin. On the other hand, hypopigmented and even depigmented lesions may not be easily recognizable in fair skin due to less contrast. Wood’s light examination becomes essential in such cases for better recognition and definition of the lesions. Despite its established role, the exact added value of using Wood’s light in recognition of vitiligo lesions has not been previously studied. Objective To verify the differential perception of vitiligo lesions between the patient and the dermatologist compared with the gold-standard detection by Wood’s lamp. Patients and methods This multicenter cross-sectional study included 200 vitiligo patients. The distribution and surface area of their facial lesions were delineated and measured as perceived by the patient, and by the dermatologist in standardized regular light and using Wood’s lamp. Results Lesional surface area as perceived by the patient and the dermatologist in regular light did not differ significantly (P=0.137), while lesions delineated under Wood’s lamp were significantly larger than both (P<0.001 in both instances), due to the detection of new clinically invisible lesions and/or invisible extensions to clinically visible lesions. The presence of these subclinical lesions was not related to Fitzpatrick’s skin phototype, vitiligo clinical type, duration, or activity score. Conclusion Subclinical lesions represent a new addition to the current spectrum of vitiligo presentations. Their detection in the current study depended solely on Wood’s light examination; hence, its use should be integral to vitiligo patient assessment. Pointing out these lesions to the patient is essential for proper application of local medications.
{"title":"Subjective versus objective recognition of facial vitiligo lesions: detection of subclinical lesions by Wood’s light","authors":"T. Anbar, M. Atwa, Rasha T A Abdel-Aziz, R. Hegazy, Sarah Ibrahim, Rabab El Genedy, A. Afify, Mohammed Anbar, C. Farid","doi":"10.4103/jewd.jewd_42_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_42_21","url":null,"abstract":"Background Visual recognition of alteration in the skin color depends upon the contrast between altered areas and their surrounding background color. The maximum contrast in vitiligo exists in dark-complexioned patients between depigmented white patches and unaffected background dark skin. On the other hand, hypopigmented and even depigmented lesions may not be easily recognizable in fair skin due to less contrast. Wood’s light examination becomes essential in such cases for better recognition and definition of the lesions. Despite its established role, the exact added value of using Wood’s light in recognition of vitiligo lesions has not been previously studied. Objective To verify the differential perception of vitiligo lesions between the patient and the dermatologist compared with the gold-standard detection by Wood’s lamp. Patients and methods This multicenter cross-sectional study included 200 vitiligo patients. The distribution and surface area of their facial lesions were delineated and measured as perceived by the patient, and by the dermatologist in standardized regular light and using Wood’s lamp. Results Lesional surface area as perceived by the patient and the dermatologist in regular light did not differ significantly (P=0.137), while lesions delineated under Wood’s lamp were significantly larger than both (P<0.001 in both instances), due to the detection of new clinically invisible lesions and/or invisible extensions to clinically visible lesions. The presence of these subclinical lesions was not related to Fitzpatrick’s skin phototype, vitiligo clinical type, duration, or activity score. Conclusion Subclinical lesions represent a new addition to the current spectrum of vitiligo presentations. Their detection in the current study depended solely on Wood’s light examination; hence, its use should be integral to vitiligo patient assessment. Pointing out these lesions to the patient is essential for proper application of local medications.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"7 - 13"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47130613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed A Mohammed, O. Shaker, T. El-Raheem, Alaa Abdulkhaleq, B. Khatery
Background Systemic sclerosis is characterized by extracellular matrix overproduction by activated fibroblasts. It was reported that microRNAs (miRNAs) participate in the regulation of processes that drive fibrosis, which include transforming growth factor-beta (TGF-β) signaling, fibroblast proliferation, differentiation, and deposition of extracellular matrix proteins. Objective To detect whether miRNA-21, miRNA-29b, miRNA-92, and miRNA-129, and TGF-β are considered as biomarkers for systemic sclerosis. Patients and methods The current study was a case–control study carried out on 80 Egyptian adults. Of the participants, 30 were apparently healthy controls, while the other 50 patients were classified into 58% with limited skin type, 26% with diffused skin type while 16% of the patients were with unclassified systemic sclerosis. miRNAs were quantitated by real-time PCR while TGF-β was measured by the ELISA technique. Results The results showed that the fold change level of miRNA-21 and miRNA-92 were upregulated compared with the control group with a P value of 0.001 each. Meanwhile, the fold change levels of miRNA-29b and miRNA-129 were downregulated compared with the control group (P=0.001, 0.048), respectively. The present study showed that the mean value of the serum level of TGF-β was 145.0±42.84 pg/ml compared with the control group 23.42±5.79 pg/ml with a P value of 0.001. There was a statistically significant negative correlation between miRNA-29 and TGF-β (r=−0.31, P=0.05) among cases. The cutoff points of miRNA-21, miRNA-29b, miRNA −92, and miRNA −129 were 2.45, 0.49, 5.38, and 0.55 fold changes. While for TGF-β, the cutoff point was 120 pg/ml. For miRNA-21, miRNA-29b, miRNA-92, and miRNA-129 sensitivities were 70.5, 41.1, 54.5, and 73.5%, respectively, and 70.5% for TGF-β. Specificity was 100% for all except 98% for miRNA-29b and 99% for miRNA-129. There was no significant relation of all these markers regarding the extent of skin involvement or duration of disease. Conclusion It was concluded that miRNA-21, miRNA-29b, miRNA-92, and miRNA-129 as well as TGF-β can be considered as biomarkers for the diagnosis of systemic sclerosis.
{"title":"Transforming growth factor-beta and microRNA-21, microRNA-29b, microRNA-92, and microRNA-129 in systemic sclerosis patients: a case–control study","authors":"Mohammed A Mohammed, O. Shaker, T. El-Raheem, Alaa Abdulkhaleq, B. Khatery","doi":"10.4103/jewd.jewd_50_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_50_21","url":null,"abstract":"Background Systemic sclerosis is characterized by extracellular matrix overproduction by activated fibroblasts. It was reported that microRNAs (miRNAs) participate in the regulation of processes that drive fibrosis, which include transforming growth factor-beta (TGF-β) signaling, fibroblast proliferation, differentiation, and deposition of extracellular matrix proteins. Objective To detect whether miRNA-21, miRNA-29b, miRNA-92, and miRNA-129, and TGF-β are considered as biomarkers for systemic sclerosis. Patients and methods The current study was a case–control study carried out on 80 Egyptian adults. Of the participants, 30 were apparently healthy controls, while the other 50 patients were classified into 58% with limited skin type, 26% with diffused skin type while 16% of the patients were with unclassified systemic sclerosis. miRNAs were quantitated by real-time PCR while TGF-β was measured by the ELISA technique. Results The results showed that the fold change level of miRNA-21 and miRNA-92 were upregulated compared with the control group with a P value of 0.001 each. Meanwhile, the fold change levels of miRNA-29b and miRNA-129 were downregulated compared with the control group (P=0.001, 0.048), respectively. The present study showed that the mean value of the serum level of TGF-β was 145.0±42.84 pg/ml compared with the control group 23.42±5.79 pg/ml with a P value of 0.001. There was a statistically significant negative correlation between miRNA-29 and TGF-β (r=−0.31, P=0.05) among cases. The cutoff points of miRNA-21, miRNA-29b, miRNA −92, and miRNA −129 were 2.45, 0.49, 5.38, and 0.55 fold changes. While for TGF-β, the cutoff point was 120 pg/ml. For miRNA-21, miRNA-29b, miRNA-92, and miRNA-129 sensitivities were 70.5, 41.1, 54.5, and 73.5%, respectively, and 70.5% for TGF-β. Specificity was 100% for all except 98% for miRNA-29b and 99% for miRNA-129. There was no significant relation of all these markers regarding the extent of skin involvement or duration of disease. Conclusion It was concluded that miRNA-21, miRNA-29b, miRNA-92, and miRNA-129 as well as TGF-β can be considered as biomarkers for the diagnosis of systemic sclerosis.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"44 - 50"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46849384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. El Enany, N. Nagui, H. Nada, M. Fawzy, Iman Sany, S. Shalaby, Omar El Ghanam
Wilson–Jones angiosarcoma is one of cutaneous angiosarcomas, which is a rare aggressive tumor of blood vessels of the skin. In this case report, we present a 72-year-old female who developed multiple episodes of facial edema of 2-year duration along with partial hair loss of the scalp. Investigations, including a skin biopsy, were diagnostic of scalp angiosarcoma.
{"title":"Wilson–Jones angiosarcoma of the scalp associated with alopecia and chest edema: a case report","authors":"G. El Enany, N. Nagui, H. Nada, M. Fawzy, Iman Sany, S. Shalaby, Omar El Ghanam","doi":"10.4103/jewd.jewd_46_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_46_21","url":null,"abstract":"Wilson–Jones angiosarcoma is one of cutaneous angiosarcomas, which is a rare aggressive tumor of blood vessels of the skin. In this case report, we present a 72-year-old female who developed multiple episodes of facial edema of 2-year duration along with partial hair loss of the scalp. Investigations, including a skin biopsy, were diagnostic of scalp angiosarcoma.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"66 - 69"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42837684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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