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Hemodialysis Catheter Breakage in an Infant. 婴儿血液透析导管破裂。
Pub Date : 2023-11-01 Epub Date: 2022-04-08 DOI: 10.1177/11297298221086854
Francisco A Nieto-Vega, Ángela García-Rojas, Inmaculada Moreno-González, Verónica Martínez-Rivera, José M Rodríguez-Mesa, Vanessa Rosa-Camacho

A 3-month-old male infant was admitted to our unit due to acute decompensation of chronic kidney disease of unknown etiology. Further investigation led to the diagnosis of primary hyperoxaluria type 1. As the patient did not recover, hemodialysis was initiated with a non-tunneled femoral catheter. A tunneled Hickman catheter was placed in the internal jugular vein. The patient experienced moderate intradialytic exit-site bleeding and catheter malfunction, which initially responded to pressure and postural changes. During the third session, the patient suffered cardiopulmonary arrest. After stabilization, a chest hematoma was identified. Fluoroscopy revealed a catheter breakage. Despite initial stabilization, the patient developed septic shock due to Pseudomonas aeruginosa and died several days later. Hemodialysis is sometimes necessary in children under 24 months with chronic kidney disease. Vascular access is a major challenge in these patients due to lack of appropriate catheter sizes and high complication rates. Hemodialysis catheter fracture is an uncommon complication, and diagnosis can be difficult when the breakage involves the subcutaneous segment. Persistent intradialytic bleeding and mechanical malfunction should raise suspicion of this complication and should elicit catheter revision under fluoroscopy. Without prompt diagnosis, catheter breakage may have fatal consequences, as in our case.

一名 3 个月大的男婴因病因不明的慢性肾病急性失代偿而被送入我科。进一步检查后诊断为原发性高草酸尿症 1 型。由于患者未能痊愈,我们开始使用非隧道式股导管进行血液透析。在颈内静脉置入了隧道式希克曼导管。患者出现中度析出部位出血和导管故障,最初对压力和体位变化有反应。在第三次治疗过程中,患者的心肺功能骤停。情况稳定后,发现胸部血肿。透视检查发现导管断裂。尽管病情初步稳定,但患者仍因铜绿假单胞菌引发脓毒性休克,数天后死亡。24 个月以下的慢性肾病患儿有时需要进行血液透析。由于缺乏合适的导管尺寸和并发症发生率高,血管通路对这些患者来说是一大挑战。血液透析导管断裂是一种不常见的并发症,如果断裂涉及皮下部分,则很难诊断。持续的血液透析内出血和机械故障应引起对这一并发症的怀疑,并应在透视下对导管进行修补。如果没有及时诊断,导管断裂可能会造成致命后果,就像我们的病例一样。
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引用次数: 1
Implementation of an Experiential Service-Learning Course in Biomedical Engineering Design for Undergraduate Students. 为本科生开设生物医学工程设计体验式服务学习课程。
Pub Date : 2023-07-01 Epub Date: 2023-01-23 DOI: 10.1007/s43683-022-00103-1
Justyn Jaworski, Michael Cho

The unique characteristics of the training needed for today's biomedical engineers can represent a challenge in curriculum design. Practical experiential learning for biomedical engineering undergraduates is important to prevent under-developed professional skills. In this teaching tips article, we provide an example of how to incorporate experiential learning into the biomedical engineering curriculum to address the need for undergraduates to gain the desired skillsets to serve as the next generation of leaders in engineering, medicine, and business all through the lens of civic engagement. Here we outline our implementation of a recently developed service-learning course for our sophomore students that allows introduction of biomedical engineering discipline-specific design process early on in their undergraduate studies. Student teams work to design, build, and test novel devices to solve the unmet need of community partners, and in doing so, the course prepares students in developing technologies that not only address public health needs but that are also embraced by the community. This course in team-based design can help train students in analyzing real world problems for needs-based biomedical engineering through projects identified by interaction with community partners. Providing specifics of how this course was implemented as well as our reflection on student learning, we offer an analysis of the areas of success, a discussion of how interactions with community partners benefits the student professional skills development, and considerations regarding implementation. Here we highlight the ability of this course to exercise students' social awareness in the design of technologies to improve society by addressing the genuine needs of community partners.

当今生物医学工程师所需的培训具有独特性,这对课程设计是一个挑战。生物医学工程本科生的实践体验学习对于防止专业技能发展不足非常重要。在这篇教学技巧文章中,我们举例说明了如何将体验式学习融入生物医学工程课程,以满足本科生获得所需技能的需求,从而通过公民参与的视角,成为工程、医学和商业领域的下一代领导者。在此,我们概述了最近为大二学生开发的服务学习课程的实施情况,该课程允许在本科学习的早期阶段介绍生物医学工程学科特定的设计过程。学生团队通过设计、建造和测试新型设备来解决社区合作伙伴尚未满足的需求,通过这样的方式,课程帮助学生做好准备,开发出不仅能满足公共卫生需求,还能受到社区欢迎的技术。这门以团队为基础的设计课程有助于培训学生通过与社区合作伙伴互动确定的项目,分析现实世界中的问题,从而开展以需求为基础的生物医学工程。我们提供了如何实施这门课程的具体细节以及我们对学生学习的反思,分析了成功的领域,讨论了与社区合作伙伴的互动如何有利于学生专业技能的发展,以及实施过程中的注意事项。在此,我们强调本课程能够锻炼学生的社会意识,通过设计技术来满足社区合作伙伴的真正需求,从而改善社会。
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引用次数: 0
Did the public attribute the Flint Water Crisis to racism as it was happening? Text analysis of Twitter data to examine causal attributions to racism during a public health crisis. 弗林特水危机发生时,公众是否将其归因于种族主义?通过对推特数据进行文本分析,研究公共卫生危机期间种族主义的因果关系。
IF 3.2 Pub Date : 2023-04-01 Epub Date: 2022-12-03 DOI: 10.1007/s42001-022-00192-6
Neslihan Bisgin, Halil Bisgin, Daniel Hummel, Jon Zelner, Belinda L Needham

The Flint Water Crisis (FWC) was an avoidable public health disaster that has profoundly affected the city's residents, a majority of whom are Black. Although many scholars and journalists have called attention to the role of racism in the water crisis, little is known about the extent to which the public attributed the FWC to racism as it was unfolding. In this study, we used natural language processing to analyze nearly six million Flint-related tweets posted between April 1, 2014, and June 1, 2016. We found that key developments in the FWC corresponded to increases in the number and percentage of tweets that mentioned terms related to race and racism. Similar patterns were found for other topics hypothesized to be related to the water crisis, including water and politics. Using sentiment analysis, we found that tweets with a negative polarity score were more common in the subset of tweets that mentioned terms related to race and racism when compared to the full set of tweets. Next, we found that word pairs that included terms related to race and racism first appeared after the January 2016 state and federal emergency declarations and a corresponding increase in media coverage of the FWC. We conclude that many Twitter users connected the events of the water crisis to race and racism in real-time. Given growing evidence of negative health effects of second-hand exposure to racism, this may have implications for understanding minority health and health disparities in the US.

弗林特水危机(FWC)是一场本可避免的公共卫生灾难,对该市居民造成了深远影响,其中大部分是黑人。尽管许多学者和记者都呼吁关注种族主义在水危机中的作用,但对于公众在多大程度上将弗林特水危机归因于种族主义却知之甚少。在这项研究中,我们使用自然语言处理技术分析了2014年4月1日至2016年6月1日期间发布的近600万条与弗林特有关的推文。我们发现,弗林特事件的主要进展与提及种族和种族主义相关词汇的推文数量和比例的增加相对应。与水危机相关的其他假设话题,包括水和政治,也发现了类似的模式。通过情感分析,我们发现与全部推文相比,在提及种族和种族主义相关词汇的推文子集中,极性得分为负的推文更为常见。接下来,我们发现包含种族和种族主义相关词汇的词对首次出现是在 2016 年 1 月州和联邦宣布紧急状态以及媒体对《联邦妇女儿童委员会》的报道相应增加之后。我们的结论是,许多推特用户实时地将水危机事件与种族和种族主义联系起来。鉴于越来越多的证据表明,二手接触种族主义会对健康产生负面影响,这可能会对了解美国少数民族的健康状况和健康差异产生影响。
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引用次数: 0
Use of pain scales and observational pain assessment tools in hospital settings. 在医院环境中使用疼痛量表和疼痛观察评估工具。
Pub Date : 2019-08-29 DOI: 10.7748/ns.2019.e11308
Julie Gregory

Pain is a personal, individual and subjective experience. The complex and dynamic nature of pain makes its assessment and management challenging for healthcare professionals. Various pain scales are available that can assist in identifying the patient's experience of pain; however, these tend to reduce this experience to a measure of pain intensity. The use of pain scales also requires patients to communicate and describe their pain; when this is not possible, it is necessary for healthcare professionals to observe patient behaviours that may indicate pain. Various observational pain assessment tools have been developed to assist in recognising and assessing pain. This article discusses the various pain scales and observational pain assessment tools that are available, and the evidence to support their use.

疼痛是一种个人的、个别的和主观的体验。疼痛的复杂性和动态性使医护人员在评估和管理疼痛时面临挑战。现有的各种疼痛量表可以帮助确定病人的疼痛体验;然而,这些量表往往将这种体验简化为疼痛强度的衡量标准。使用疼痛量表还需要患者对自己的疼痛进行交流和描述;如果无法做到这一点,医护人员就有必要观察患者可能表示疼痛的行为。为了帮助识别和评估疼痛,人们开发了各种疼痛观察评估工具。本文将讨论现有的各种疼痛量表和疼痛观察评估工具,以及支持使用这些工具的证据。
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引用次数: 0
SEM Observation of Wet Lily Pollen Grains Pretreated with Ionic Liquid 离子液体预处理湿百合花粉颗粒的SEM观察
Pub Date : 2014-09-23 DOI: 10.2503/JJSHS1.MI-008
F. Komai, Kanako Okada, Y. Inoue, M. Yada, Osamu Tanaka, S. Kuwabata
Mature pollen grains of Lilium cultivar, with their germ pores folded in upon themselves, were observed under a scanning electron microscope (SEM). The conventional pretreatment process requires aldehyde fixation, dehydration, drying and metal sputtering for SEM observation. These complicated and laborious procedures can considerably alter the morphology of pollen grains. In order to omit this conventional pretreatment process, we established a novel technique utilizing an ionic liquid (IL) that is composed solely of ions, namely, a liquid salt that can remain in a molten state even at room temperature. IL-treated pollen grains could be observed under vacuum conditions without artifacts, and furthermore, a satisfactory SEM image could visualize pollen grains in a wet state. The possible direction of future studies on ionic liquids in the SEM field is also discussed.
在扫描电子显微镜下观察了百合成熟花粉粒的胚芽向内折叠的情况。传统的预处理工艺需要醛固、脱水、干燥和金属溅射进行SEM观察。这些复杂而费力的过程可以大大改变花粉粒的形态。为了省去这种传统的预处理过程,我们建立了一种利用离子液体(IL)的新技术,这种离子液体仅由离子组成,即液体盐,即使在室温下也能保持熔融状态。il处理后的花粉可以在真空条件下观察到无伪影的花粉粒,并且可以在潮湿状态下看到令人满意的SEM图像。最后对离子液体在扫描电镜领域的研究方向进行了展望。
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引用次数: 6
Cutting Leaves and Plant Growth Regulator Application Enhance Somaclonal Variation Induced by Transposition of VGs1 of Saintpaulia 刈割叶片和植物生长调节剂的应用增强了圣保罗州VGs1转位诱导的体细胞无性系变异
Pub Date : 2014-09-20 DOI: 10.2503/JJSHS1.MI-009
Sayumi Matsuda, Mitsuru Sato, S. Ohno, S. Yang, M. Doi, M. Hosokawa
For determination of the endogenous and exogenous causes of somaclonal variation in in vitro culture, a bioassay system was developed using the variegated Saintpaulia (African violet) ‘Thamires’ (Saintpaulia sp.), having pink petals with blue splotches caused by transposon VGs1 (Variation Generator of Saintpaulia 1) deletion in the promoter region of flavonoid 3',5'-hydroxylase. Not only true-to-type but also many solid blue and chimeric plants regenerate in vitro-cultured explants of this cultivar. Using multiplex PCR that enables the determination of these variations, we attempted to evaluate the effects of four candidate triggers of mutation: pre-existing mutated cells, shooting conditions in vitro or ex vitro, cutting treatment of explants, and addition of plant growth regulators (PGRs) to the medium. The percentages of somaclonal variations among total shoots regenerated from leaf segments and stamens were 46.6 and 56.5, which were higher than the percentages expected from pre-existing mutated cells (3.6 and 1.4, respectively). These results indicate that pre-existing mutated cells are not a main cause of somaclonal variations. The percentage of somaclonal variation was independent of culture conditions for mother plants; the mutation percentages of adventitious shoots regenerated from ex vitroand in vitro-grown leaves were 9.2% and 8.5%, respectively. In addition, the percentage of somaclonal variations of adventitious shoots regenerated under in vitro conditions from the in vitro grown mother plants was also low, at 4.9%. This indicates that the in vitro condition itself is not a main cause of somaclonal variation. However, when adventitious shoots were regenerated from 10 × 5-mm cut-leaf laminas on a PGR-free medium, the percentage of somaclonal variation was 26.4%. In addition, the percentage of somaclonal variations dramatically increased when PGRs were added to the medium for both leaves and leaf segments (39.9 and 46.6, respectively). The bioassay system using Saintpaulia ‘Thamires’ will enable the screening of many environmental factors because of its rapidity and ease of use and will facilitate the development of a new tissue culture technology for avoiding mutation.
为了确定离体培养中体细胞无性系变异的内源和外源原因,利用杂交的Saintpaulia(非洲紫罗兰)' Thamires ' (Saintpaulia sp.)开发了一种生物测定系统,该系统具有粉红色花瓣和蓝色斑点,这是由类黄酮3',5'-hydroxylase启动子区域的转座子VGs1(变异产生者Saintpaulia 1)缺失引起的。该品种在离体培养的外植体中不仅可以获得真型植株,还可以获得许多纯蓝色植株和嵌合植株。利用多重PCR技术确定这些变异,我们试图评估四种候选突变触发因素的影响:预先存在的突变细胞、体外或离体射击条件、外植体切割处理以及在培养基中添加植物生长调节剂(pgr)。叶片和雄蕊再生总芽的体细胞无性系变异率分别为46.6%和56.5,高于原有突变细胞的体细胞无性系变异率(分别为3.6和1.4)。这些结果表明,预先存在的突变细胞不是体细胞无性系变异的主要原因。体细胞无性系变异百分率与母株培养条件无关;离体叶片和离体叶片再生不定芽的突变率分别为9.2%和8.5%。此外,在离体条件下由离体母株再生的不定芽的体细胞无性系变异率也很低,为4.9%。这表明体外条件本身并不是体细胞无性系变异的主要原因。而在无pgr培养基上从10 × 5-mm的切叶薄片再生不定芽时,体细胞无性系变异率为26.4%。叶片和叶段的体细胞无性系变异比例均显著增加(分别为39.9%和46.6%)。使用Saintpaulia ' Thamires '的生物测定系统由于其快速和易于使用,将能够筛选许多环境因素,并将促进新的组织培养技术的发展,以避免突变。
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引用次数: 14
Effect of Root-zone Heating on Root Growth and Activity, Nutrient Uptake, and Fruit Yield of Tomato at Low Air Temperatures 低温下根区加热对番茄根系生长活性、养分吸收及产量的影响
Pub Date : 2014-09-03 DOI: 10.2503/JJSHS1.MI-001
Y. Kawasaki, S. Matsuo, Y. Kanayama, K. Kanahama
. Smeets, L. and F. Garretsen. 1986. Growth analyses of tomato genotypes grown under low night temperatures and low light intensity. Euphytica 35: 701–715. Tindall, J. A., H. A. Mills and D. E. Radcliffe. 1990. The effect of root zone temperature on nutrient uptake of tomato. J. Plant
. Smeets, L.和F. Garretsen. 1986。低温弱光条件下番茄基因型的生长分析。植物学报35:701-715。J. A.廷德尔、H. A.米尔斯和D. E.拉德克利夫,1990。根区温度对番茄养分吸收的影响。j .植物
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引用次数: 29
Low Temperature Increases Ethylene Sensitivity in Actinidia chinensis ‘Rainbow Red’ Kiwifruit 低温增加猕猴桃‘彩虹红’的乙烯敏感性
Pub Date : 2014-09-02 DOI: 10.2503/JJSHS1.CH-104
S. Murakami, Y. Ikoma, M. Yano
Premature softening during low-temperature storage is a major issue in the red kiwifruit (Actinidia chinensis Planch.) cultivar ‘Rainbow Red’. The objective of this study was to investigate the effect of low temperature on ethylene sensitivity in this cultivar. We demonstrate how ethylene preconditioning at 4°C and 25°C interacted with more rapidly ripening at the lower temperature in ‘Rainbow Red’ kiwifruit. The expression of ripeningrelated genes ACS1, ACO3, EIL4, ERF14, and PGB was at the basal level during ethylene preconditioning at 4°C and 25°C, and rapidly increased with ethylene treatment following ripening. These results suggest that low-temperature storage enhances ethylene sensitivity in ‘Rainbow Red’.
彩虹红猕猴桃(Actinidia chinensis Planch.)品种“彩虹红”在低温贮藏过程中过早软化是一个主要问题。本研究旨在探讨低温对该品种乙烯敏感性的影响。我们展示了乙烯预处理在4°C和25°C下如何与“彩虹红”猕猴桃在较低温度下更快成熟相互作用。成熟相关基因ACS1、ACO3、EIL4、ERF14和PGB的表达在4°C和25°C乙烯预处理时处于基础水平,成熟后随着乙烯处理迅速增加。这些结果表明,低温储存增强了“彩虹红”的乙烯敏感性。
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引用次数: 11
Quality Change of Asparagus Spears Stored with Snow Cooling 雪冷贮藏芦笋笋的品质变化
Pub Date : 2014-09-02 DOI: 10.2503/JJSHS1.CH-113
K. Nikaido, T. Jishi, T. Maeda, Takashi Suzuki, H. Araki
. Kobiyama, M. 2003. Oil equivalence and CO2 reduction effect of snow. Mem. Muroran Inst. Tech. 53: 3–5 (In Japanese with
. 小山,M. 2003。雪的油当量和CO2减排效果。Mem。Muroran institute Tech. 53: 3-5(日语)
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引用次数: 8
Development of Molecular Markers Associated with Sexuality in Diospyros lotus L. and Their Application in D. kaki Thunb. 莲藕性相关分子标记的开发及其在枇杷中的应用。
Pub Date : 2014-07-31 DOI: 10.2503/JJSHS1.CH-109
T. Akagi, Kei Kajita, T. Kibe, H. Morimura, T. Tsujimoto, S. Nishiyama, T. Kawai, H. Yamane, R. Tao
Sexuality of crops affects both cultivation and breeding systems. Cultivated persimmon (Diospyros kaki Thunb) has a morphologically well-characterized polygamous or gyonodioecious sexual system. However, the genetic basis of sexuality in D. kaki has yet to be characterized. Here, we used dioecious D. lotus L., a diploid wild relative species to hexaploid or nonaploid D. kaki, as a model to clarify the genetic basis of sexuality in Diospyros and to develop molecular markers associated with the sexuality of individuals. Using 62 F1 offspring segregated into distinct male/female phenotypes, we found two amplified fragment-length polymorphism markers, DlSx-AF4 and DlSx-AF7, which cosegregated with maleness. This could suggest that the sexuality of D. lotus is controlled by a single gene/haploblock, and the male is dominant over the female. Thus, D. lotus’s sexuality can be described as the heterogametic male type, the XY-type, as reported for most other dioecious plant species. For unknown reasons, segregation of the phenotype of a sequence-characterized amplified region marker developed from DlSx-AF4 (DlSx-AF4S) and/or the male/female phenotype in two different crosses in D. lotus showed an apparent bias towards femaleness and better fitted 1:2 than 1:1, which is the theoretical segregation for a single genetic locus or haploblock in diploid D. lotus. DlSx-AF4S could distinguish D. kaki cultivars with female and male flowers from cultivars with only female flowers, strongly indicating that the same genetic system controls D. kaki’s sexuality and that DlSx-AF4S could be used as a genetic marker for sexuality in D. kaki breeding programs.
作物的性向对栽培和育种系统都有影响。栽培柿子(Diospyros kaki Thunb)具有形态学特征良好的一夫多妻制或雌雄异株性系统。然而,雌雄同体的遗传基础尚未被确定。本研究以六倍体或非单倍体kaki的二倍体野生亲缘种雌雄异株D. lotusl .为模型,阐明了Diospyros性别的遗传基础,并开发了与个体性别相关的分子标记。利用62个不同雌雄表型的F1后代,我们发现两个片段长度多态性扩增标记DlSx-AF4和DlSx-AF7与雄性共分离。这可能表明荷花的性别是由一个单基因/单倍体块控制的,雄性比雌性占优势。因此,与大多数其他雌雄异株植物一样,荷花的性取向可以被描述为异交雄型,即xy型。由DlSx-AF4 (DlSx-AF4S)构建的序列特征扩增区标记的表型分离和/或两个不同杂交的雄性/雌性表型分离明显倾向于雌性,且1:2比1:1更适合,这是二倍体荷花中单个遗传位点或单倍体块的理论分离。DlSx-AF4S可以区分出雌雄花的山核桃品种和只有雌花的山核桃品种,这有力地说明了相同的遗传系统控制着山核桃的性向,并且可以作为山核桃育种中的性向遗传标记。
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引用次数: 26
期刊
Journal of The Japanese Society for Horticultural Science
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