In the present study, S alvia sclarea L. was collected during to flowering stage in 2016, Saricakaya (Eskisehir/Turkey) and dried medicinal plant materials were macerated with 70% MeOH. The antimicrobial activity of Salvia sclarea extracts was determined with minimum inhibitory concentration (MIC) assay against Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 29213 and Candida albicans ATCC 90028. The antibiofilm activity of Salvia sclarea extracts was determined against Staphylococcus aureus ATCC 29213 and Staphylococcus epidermidis ATCC 14990. And the preliminary cytotoxicity assessment of extracts was tested with Brine Shrimp Lethality Assay against model organism Artemia salina nauplii. As a result, Salvia sclarea extract showed remarkably antibacterial activity while it showed no effect on Candida albicans ATCC 90028. Moreover, antibiofilm activity could not be determined. The lethality effect also could not be determined due to high dose concentrations.
{"title":"Determination of Antimicrobial and Biological Activities of Salvia sclarea L. (Lamiaceae) Extracts","authors":"Sevim Küçük, P. Soyer, Y. Tunalı","doi":"10.18596/JOTCSA.463681","DOIUrl":"https://doi.org/10.18596/JOTCSA.463681","url":null,"abstract":"In the present study, S alvia sclarea L. was collected during to flowering stage in 2016, Saricakaya (Eskisehir/Turkey) and dried medicinal plant materials were macerated with 70% MeOH. The antimicrobial activity of Salvia sclarea extracts was determined with minimum inhibitory concentration (MIC) assay against Escherichia coli ATCC 35218, Staphylococcus aureus ATCC 29213 and Candida albicans ATCC 90028. The antibiofilm activity of Salvia sclarea extracts was determined against Staphylococcus aureus ATCC 29213 and Staphylococcus epidermidis ATCC 14990. And the preliminary cytotoxicity assessment of extracts was tested with Brine Shrimp Lethality Assay against model organism Artemia salina nauplii. As a result, Salvia sclarea extract showed remarkably antibacterial activity while it showed no effect on Candida albicans ATCC 90028. Moreover, antibiofilm activity could not be determined. The lethality effect also could not be determined due to high dose concentrations.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46748968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Considerable effort in the field of periodontal tissue engineering has been expended in the construction of advanced biomatrix for the treatment of periodontal diseases caused by poor oral hygiene, malnutrition, genetic factors, and systemic disorders. With this in mind, the ultimate goal of this investigation is to fabricate sophisticated scaffolds using jellyfish collagen (JC) and aqueous Salvadora persica (Miswak) extracts. Rhizostoma pulmo species JC was isolated and characterized in depth. Miswak was extracted using two different methods. The extraction yield was calculated to be 14.2 ± 0.9 % and 17.1 ± 0.4 % for the Method I and II, respectively. gas chromatography-mass spectroscopy (GC-MS) results revealed the extract to be composed of 1,8-cineole (49.3 %), benzyl nitrile (36.2 %), benzyl isothiocyanate (5.9 %), limonene (2.4 %), eugenol (0.8 %) and palmitic acid (0.3 %). Total phenolic content and antioxidant capacities of the extracts were also determined by spectrophotometrically. Human periodontal ligament fibroblast cells were isolated and expanded. Cell viability on JC and miswak extract-laden JC scaffolds was determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. Microarchitectures of the JC, 0.05 and 0.1% miswak extract-laden JC scaffolds and also cellular behaviors on these surfaces were evaluated by scanning electron microscopy (SEM) analysis. This study suggests that miswak extract-laden JC scaffolds would present new opportunities for periodontal tissue engineering.
{"title":"Salvadora persica Extract-laden Jellyfish Collagen Hybrid Constructs for Periodontal Tissue Regeneration","authors":"Y. E. Arslan, Ilkim Kantarcioglu","doi":"10.18596/JOTCSA.484936","DOIUrl":"https://doi.org/10.18596/JOTCSA.484936","url":null,"abstract":"Considerable effort in the field of periodontal tissue engineering has been expended in the construction of advanced biomatrix for the treatment of periodontal diseases caused by poor oral hygiene, malnutrition, genetic factors, and systemic disorders. With this in mind, the ultimate goal of this investigation is to fabricate sophisticated scaffolds using jellyfish collagen (JC) and aqueous Salvadora persica (Miswak) extracts. Rhizostoma pulmo species JC was isolated and characterized in depth. Miswak was extracted using two different methods. The extraction yield was calculated to be 14.2 ± 0.9 % and 17.1 ± 0.4 % for the Method I and II, respectively. gas chromatography-mass spectroscopy (GC-MS) results revealed the extract to be composed of 1,8-cineole (49.3 %), benzyl nitrile (36.2 %), benzyl isothiocyanate (5.9 %), limonene (2.4 %), eugenol (0.8 %) and palmitic acid (0.3 %). Total phenolic content and antioxidant capacities of the extracts were also determined by spectrophotometrically. Human periodontal ligament fibroblast cells were isolated and expanded. Cell viability on JC and miswak extract-laden JC scaffolds was determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide (MTT) assay. Microarchitectures of the JC, 0.05 and 0.1% miswak extract-laden JC scaffolds and also cellular behaviors on these surfaces were evaluated by scanning electron microscopy (SEM) analysis. This study suggests that miswak extract-laden JC scaffolds would present new opportunities for periodontal tissue engineering.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42957076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photo-initiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have been performed under different pH conditions.
{"title":"Study on the preparation and drug release property of Modified PEG-DA based hydrogels","authors":"Ş. Şenol, E. Akyol","doi":"10.18596/JOTCSA.485817","DOIUrl":"https://doi.org/10.18596/JOTCSA.485817","url":null,"abstract":"The aim of the present study is to develop hydroxyapatite modified PEG-DA and PEG-DA/HEMA based hydrogels for release of Donepezil HCl for potential treatment of Alzheimer’s disease. [2,2-Dimethoxy-2-phenyl-acetophenone] (Irgacure 651), 1 Hydroxycyclohexyl phenyl ketone (Irgacure 184) and 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) were used as photo-initiators in the synthesis of hydrogels and hydroxyapatite was used for modifying hydrogels. Fourier transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM) and digital microscope were utilized to investigate the characteristics properties of hydrogels. Photopolymerization technique was selected to synthesize for hydrogels. Swelling and drug release studies have been performed under different pH conditions.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44745727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suleyman Akocak, M. Boğa, Nabih Lolak, Muhammed Tuneğ, R. K. Sanku
1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting diazonium salt of sulfanilamide and substituted aromatic amine derivatives 3(a-k) . The obtained compounds were investigated for antioxidant properties by using different methods such as a DPPH radical scavenging assay, ABTS radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The cholinesterase inhibition activities (acetylcholinesterase and butyrylcholinesterase) of synthesized compounds were also tested. In general, compounds showed weak antioxidant activity, except compounds 4d (IC 50 =114.89 for DPPH activity), 4i (IC 50 =25.31 for ABTS activity), 4a (IC 50 = 86.33 for metal chelating activity), and 4k (absorbance value 1.229 µM for CUPRAC). Some of the compounds showed great % inhibition against both acetylcholinesterase and butyrylcholinesterase with % inhibition values ranging from 11.54 to 93.67 and 62.24 to 98.47, respectively.
{"title":"Design, synthesis and biological evaluation of 1,3-diaryltriazene-substituted sulfonamides as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors","authors":"Suleyman Akocak, M. Boğa, Nabih Lolak, Muhammed Tuneğ, R. K. Sanku","doi":"10.18596/JOTCSA.516444","DOIUrl":"https://doi.org/10.18596/JOTCSA.516444","url":null,"abstract":"1,3-diaryltriazenes are one of the most useful and important linkers for many pharmaceutical applications. Therefore, in the current work, a series of 1,3-diaryltriazene sulfonamides 4(a-k) were synthesized by reacting diazonium salt of sulfanilamide and substituted aromatic amine derivatives 3(a-k) . The obtained compounds were investigated for antioxidant properties by using different methods such as a DPPH radical scavenging assay, ABTS radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The cholinesterase inhibition activities (acetylcholinesterase and butyrylcholinesterase) of synthesized compounds were also tested. In general, compounds showed weak antioxidant activity, except compounds 4d (IC 50 =114.89 for DPPH activity), 4i (IC 50 =25.31 for ABTS activity), 4a (IC 50 = 86.33 for metal chelating activity), and 4k (absorbance value 1.229 µM for CUPRAC). Some of the compounds showed great % inhibition against both acetylcholinesterase and butyrylcholinesterase with % inhibition values ranging from 11.54 to 93.67 and 62.24 to 98.47, respectively.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44545419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
F. Emen, R. E. Demirdöğen, G. Avsar, A. I. Karaçolak
Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutants in water resources. Therefore, it is of great concern to develop advanced sorbent materials for effective and efficient removal of metals and oil from water. In this study, synthesis of new LDH composites which would be used for sorption of heavy metals and oils from polluted water. For this purpose, MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite was prepared and characterized were made via FT-IR and XRD. The XRD powder pattern of the composite showed that it contained g -Fe 2 O 3 (PDF card no:00-002-1047), MgAl(OH)14.XH 2 O (PDF card no:00-043-0072) and MoS 2 (PDF card no:00-037-4492). Thermal stability of the composite was investigated via DTA/TG technique. MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite was shows highly efficient sorption for vegetable oil up to 418% times its own weight. The ablity of MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite for removing Pb 2+ ions from aqueous solution. Pb 2+ analysis was made by ICP-OES. The effect of Pb 2+ amounts, PH, sorbent amounts and solvent flow rate on t he adsorption capacity of MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite were also ivestigated.
{"title":"LDH- ɣ-Fe2O3-MoS2 composite for Vegetable Oil and Pb2+ Removal From Water","authors":"F. Emen, R. E. Demirdöğen, G. Avsar, A. I. Karaçolak","doi":"10.18596/JOTCSA.466768","DOIUrl":"https://doi.org/10.18596/JOTCSA.466768","url":null,"abstract":"Water pollution is a global concern. Inorganic and organic pollutants constitute primary pollutants in water resources. Therefore, it is of great concern to develop advanced sorbent materials for effective and efficient removal of metals and oil from water. In this study, synthesis of new LDH composites which would be used for sorption of heavy metals and oils from polluted water. For this purpose, MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite was prepared and characterized were made via FT-IR and XRD. The XRD powder pattern of the composite showed that it contained g -Fe 2 O 3 (PDF card no:00-002-1047), MgAl(OH)14.XH 2 O (PDF card no:00-043-0072) and MoS 2 (PDF card no:00-037-4492). Thermal stability of the composite was investigated via DTA/TG technique. MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite was shows highly efficient sorption for vegetable oil up to 418% times its own weight. The ablity of MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite for removing Pb 2+ ions from aqueous solution. Pb 2+ analysis was made by ICP-OES. The effect of Pb 2+ amounts, PH, sorbent amounts and solvent flow rate on t he adsorption capacity of MgAlOH- ɣ -Fe 2 O 3 -MoS 2 composite were also ivestigated.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42477984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO 2 ) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO 2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m 2 /g 2-chloro-benzoythiourea modified MCM-4, respectively . The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.
{"title":"2-Chlorobenzoylthiourea-modified MCM-41 for Drug Delivery","authors":"F. Emen, R. E. Demirdöğen, G. Avsar, D. Kiliç","doi":"10.18596/JOTCSA.467177","DOIUrl":"https://doi.org/10.18596/JOTCSA.467177","url":null,"abstract":"Mesoporous 2-Chlorobenzoylthiourea-modified MCM-41 was prepared and loaded with ibuprofen in a supercritical carbon dioxide (sC-CO 2 ) environment. 2-chloro-benzoythiourea modified MCM-41 was prepared and also characterized via XRD, FT-IR, SEM and BET techniques. The (100) and (110) reflections observed at low angle XRD show the mesoporous SiO 2 structure. The paticule size of non-uniform spheres were observed at a range of 250-305 nm. BET surface areas were calculated as 1506 m2 / g for MCM-41 and 306 m 2 /g 2-chloro-benzoythiourea modified MCM-4, respectively . The absorption and releasing studies of ibuprofen were caried out in simulated body fluid. The result revealed that high adsorption capacity for drug with 2-chloro-benzoythiourea modified MCM-41 and slower drug release rate was achieved.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47329344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper, we demonstrated the results of ethanol, methanol and higher alcohols contents of the legally and illegally produced alcoholic beverage samples after analyzing headspace gas chromatographic methods conducted in Council of Forensic Medicine (ATK), Department of Chemistry, Istanbul, TURKEY between years 2015-2017. Fast and reliable analysis of the alcoholic beverages, especially in terms of methanol concentration, has vital importance primarily due to the cases of death arose from metabolic acidosis after consumption of illicit alcoholic beverages with high concentration of methanol produced in clandestine laboratories. 96 Turkish Raki samples, 8 beer samples, 1 wine sample, 101 other strong drink samples, totaling to 206 samples, and 2 industrial ethanol samples were thoroughly investigated. An HS-GC-MS system was utilized for qualitative analysis of the higher alcohols and for scanning any volatile compound, whereas the determination of ethanol and methanol concentrations HS-GC-FID system was performed. So, after all results were investigated in detail, mentioning the key points for evaluations, it was clearly described whether the drinks comply with criteria set by Turkish Food Codex Communique on Distilled Alcoholic Beverages. 89 of 96 Raki samples and 90 of 101 strong alcoholic beverages were not definitely compliant with the Communique since they contained either high concentration levels of methanol or tert-butanol, which is a denaturant.
{"title":"DETERMINATION AND EVALUATION OF METHANOL, ETHANOL AND HIGHER ALCOHOLS IN LEGALLY AND ILLEGALLY PRODUCED ALCOHOLIC BEVERAGES","authors":"O. Destanoğlu, I. Ateş","doi":"10.18596/JOTCSA.481384","DOIUrl":"https://doi.org/10.18596/JOTCSA.481384","url":null,"abstract":"In this paper, we demonstrated the results of ethanol, methanol and higher alcohols contents of the legally and illegally produced alcoholic beverage samples after analyzing headspace gas chromatographic methods conducted in Council of Forensic Medicine (ATK), Department of Chemistry, Istanbul, TURKEY between years 2015-2017. Fast and reliable analysis of the alcoholic beverages, especially in terms of methanol concentration, has vital importance primarily due to the cases of death arose from metabolic acidosis after consumption of illicit alcoholic beverages with high concentration of methanol produced in clandestine laboratories. 96 Turkish Raki samples, 8 beer samples, 1 wine sample, 101 other strong drink samples, totaling to 206 samples, and 2 industrial ethanol samples were thoroughly investigated. An HS-GC-MS system was utilized for qualitative analysis of the higher alcohols and for scanning any volatile compound, whereas the determination of ethanol and methanol concentrations HS-GC-FID system was performed. So, after all results were investigated in detail, mentioning the key points for evaluations, it was clearly described whether the drinks comply with criteria set by Turkish Food Codex Communique on Distilled Alcoholic Beverages. 89 of 96 Raki samples and 90 of 101 strong alcoholic beverages were not definitely compliant with the Communique since they contained either high concentration levels of methanol or tert-butanol, which is a denaturant.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48401252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"PREPARATION OF POLY(PYROMELLITIC DIANHYDRIDE-CO-THIONIN) MODIFIED VOLTAMMETRIC SENSOR FOR THE DETERMINATION OF EPICATECHIN","authors":"Serap Titretir Duran","doi":"10.18596/jotcsa.446953","DOIUrl":"https://doi.org/10.18596/jotcsa.446953","url":null,"abstract":"","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67537386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, four new dithiophosphonic acid complexes, namely, trans- bis-[ O– 3-phenyl-1-prop yl- (4-methoxyphenyl) dithiophosphonato ] nickel (II), {Bis-pyridine-bis-(O–3–phenylpropyl (4-methoxyphenyl) dithiophosphonato ]} nickel (II), bis-{bis-( O– 3-phenyl-1-prop yl- (4-methoxyphenyl) dithiophosphonato ] cadmium (II)} and bis - { bis - ( O– 3 - phenyl – 1 - prop yl- ( 4-methoxyphenyl ) dithiophosphonato ] mercury (II)} were syntheszed. The complexes were of the general structure [Ni(L) 2 ] and [M(µ-L) 2 (L) 2 ], M= Cd 2+ and Hg 2+ . The nickel(II) complex was capable of coordinating two moles of pyridine per mole as many four-coordinated nickel(II) complex do leading to the six-coordinated complex, [Ni(L) 2 (Py) 2 ]. All the compounds were characterized by elemental analysis; MS; FTIR and Raman spectroscopies. The [ Ni( L ) 2 ], [Cd(µ-L) 2 (L) 2 ] and [Hg(µ-L) 2 (L) 2 ] were also investigated by 1 H-, 13 C- and 31 P-NMR. The magnetic susceptibility of the pyridine nickel complex was measured to confirm the hybridization patterns and the geometry.
{"title":"Syntheses and Spectroscopic Characterization on New [O–3-phenyl-1-propyl-(4-methoxyphenyl)dithiophosphonato] Ni(II), Cd(II) and Hg(II) Complexes","authors":"Ertuğrul Gazi SAĞLAM SAĞLAM, Ahmet Ebinç","doi":"10.18596/JOTCSA.468027","DOIUrl":"https://doi.org/10.18596/JOTCSA.468027","url":null,"abstract":"In this study, four new dithiophosphonic acid complexes, namely, trans- bis-[ O– 3-phenyl-1-prop yl- (4-methoxyphenyl) dithiophosphonato ] nickel (II), {Bis-pyridine-bis-(O–3–phenylpropyl (4-methoxyphenyl) dithiophosphonato ]} nickel (II), bis-{bis-( O– 3-phenyl-1-prop yl- (4-methoxyphenyl) dithiophosphonato ] cadmium (II)} and bis - { bis - ( O– 3 - phenyl – 1 - prop yl- ( 4-methoxyphenyl ) dithiophosphonato ] mercury (II)} were syntheszed. The complexes were of the general structure [Ni(L) 2 ] and [M(µ-L) 2 (L) 2 ], M= Cd 2+ and Hg 2+ . The nickel(II) complex was capable of coordinating two moles of pyridine per mole as many four-coordinated nickel(II) complex do leading to the six-coordinated complex, [Ni(L) 2 (Py) 2 ]. All the compounds were characterized by elemental analysis; MS; FTIR and Raman spectroscopies. The [ Ni( L ) 2 ], [Cd(µ-L) 2 (L) 2 ] and [Hg(µ-L) 2 (L) 2 ] were also investigated by 1 H-, 13 C- and 31 P-NMR. The magnetic susceptibility of the pyridine nickel complex was measured to confirm the hybridization patterns and the geometry.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42007700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.
{"title":"Mineralization of Hydrochlorothiazide using Hydrogen Peroxide in Subcritical Water","authors":"Erdal Yabalak, Özkan Görmez, Yahya Nural","doi":"10.18596/jotcsa.449979","DOIUrl":"https://doi.org/10.18596/jotcsa.449979","url":null,"abstract":"In this paper, we investigated the mineralization of hydrochlorothiazide, a diuretic drug which is used for the treatment of hypertension, using H 2 O 2 as the oxidizing agent in subcritical water as a medium. Response surface methodology was applied to optimize experimental parameters such as temperature, treatment time, and concentration of the oxidizing agent. 85.22% of TOC removal was obtained at 403 K, 80 mM of hydrogen peroxide and 147.3 min. The reliability of the performed method was evaluated by ANOVA and the theoretical equation of TOC removal of hydrochlorothiazide was proposed. F and p values of the model were determined as 62.88 and lower than 0.0001, respectively.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45391678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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