Suleyman Akocak, Nabih Lolak, Muhammed Tuneğ, M. Boğa
In this work, a series of histamine Schiff bases H(1-20) were synthesized by reacting histamine and substituted aldehydes A(1-20) . The compounds were assayed for antioxidant properties by using different bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of the compounds showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with % inhibition of 97.03 and 93.64, respectively.
{"title":"Antioxidant, acetylcholinesterase and butyrylcholinesterase inhibition profiles of histamine Schiff bases","authors":"Suleyman Akocak, Nabih Lolak, Muhammed Tuneğ, M. Boğa","doi":"10.18596/JOTCSA.521291","DOIUrl":"https://doi.org/10.18596/JOTCSA.521291","url":null,"abstract":"In this work, a series of histamine Schiff bases H(1-20) were synthesized by reacting histamine and substituted aldehydes A(1-20) . The compounds were assayed for antioxidant properties by using different bioanalytical methods such as DPPH free radical scavenging assay, ABTS cation radical decolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods. The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles were also assessed. In general, the synthesized compounds showed weak antioxidant activity against all tested methods, but some of the compounds showed great inhibition potency against AChE and BChE enzymes. Specifically, compound H9 showed effective inhibition potency against both enzymes with % inhibition of 97.03 and 93.64, respectively.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41812099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Four ligands based on chromene derivatives have been docked into integrase of prototype foamy virus, which has a quite similar structural similarity with that of HIV-1 integrase using Autodock Vina (Vina). The docking scores for the derivatives are -7.3 kcal/mol, -7.5 kcal/mol, -6.9 kcal/mol, and -7.2 kcal/mol, respectively, which are comparable with that for Raltegravir (-10.7 kcal/mol). The docking results provide a detailed evidence for the interactions of four chromene derivatives. The results may lead to the design and development of new drug candidates against AIDS
{"title":"Molecular Docking Study of Four Chromene Derivatives as Novel HIV-1 Integrase Inhibitors","authors":"N. Arslan","doi":"10.18596/JOTCSA.478772","DOIUrl":"https://doi.org/10.18596/JOTCSA.478772","url":null,"abstract":"Four ligands based on chromene derivatives have been docked into integrase of prototype foamy virus, which has a quite similar structural similarity with that of HIV-1 integrase using Autodock Vina (Vina). The docking scores for the derivatives are -7.3 kcal/mol, -7.5 kcal/mol, -6.9 kcal/mol, and -7.2 kcal/mol, respectively, which are comparable with that for Raltegravir (-10.7 kcal/mol). The docking results provide a detailed evidence for the interactions of four chromene derivatives. The results may lead to the design and development of new drug candidates against AIDS","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43372030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nanotechnology provides promising possibilities for several biomedical and pharmaceutical applications in the medicine industry. Nanostructures play a major role in the recent strategies of technology suitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures were synthesised using the sonochemical technique at room temperature. The characterization of the clindamycin phosphate- xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated in vitro the mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, the concentration of drug in the solution was analyzed by UV–vis spectroscopy method and several kinetic models and error analysis were calculated to prove a connection with results. The Higuchi model had the best correlation parameters. The percentage of swelling ratio (%) reached up 105% in XaG (pH 1.2) and 190% in XaG/ZnO (pH 1.2) And the swelling ratio (%) reached up 530% within in XaG (pH 7.4) and 655% within in XaG/ZnO (pH 7.4). The results show that the capacity of XaG / ZnO can be preferred as a novel topical anti-inflammatory drug carrier.
{"title":"A Novel ZnO Nanoparticle as Drug Nanocarrier in Therapeutic applications: Kinetic Models and Error Analysis","authors":"S. Karakuş","doi":"10.18596/JOTCSA.405505","DOIUrl":"https://doi.org/10.18596/JOTCSA.405505","url":null,"abstract":"Nanotechnology provides promising possibilities for several biomedical and pharmaceutical applications in the medicine industry. Nanostructures play a major role in the recent strategies of technology suitable for novel drug applications. In this work, clindamycin phosphate (CliP) (topical anti-inflammatory drug), xanthan gum (XaG) (biopolymer) and ZnO (zinc oxide) (nanoparticle) nanostructures were synthesised using the sonochemical technique at room temperature. The characterization of the clindamycin phosphate- xanthan gum/ZnO (CliP-XaG/ZnO) nanostructure has been carried out by Fourier transform infrared (FTIR) and X-ray diffraction (XRD). The spectroscopic experiments elucidated in vitro the mechanism of drug delivery system at different pH media (1.2 and 7.4). In this study, the concentration of drug in the solution was analyzed by UV–vis spectroscopy method and several kinetic models and error analysis were calculated to prove a connection with results. The Higuchi model had the best correlation parameters. The percentage of swelling ratio (%) reached up 105% in XaG (pH 1.2) and 190% in XaG/ZnO (pH 1.2) And the swelling ratio (%) reached up 530% within in XaG (pH 7.4) and 655% within in XaG/ZnO (pH 7.4). The results show that the capacity of XaG / ZnO can be preferred as a novel topical anti-inflammatory drug carrier.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42523950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the present work, a series of quaternized antibacterial polystyrenes (Anti-PSts) with various molecular weights are synthesized and characterized. Initially, ω-bromo end functional polystyrenes with different molecular weights (PSt-Br-1, PSt-Br-2 and PSt-Br-2) are synthesized by atom transfer radical polymerization (ATRP). Then, the ω–bromo functionalities of obtained PSt-Brs are reacted with trimethylamine (TEA) to achieve corresponding antibacterial properties. PSt-Brs and Anti-PSts produced are structurally characterized by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy ( 1 H-NMR), and gel permeation chromatography (GPC) at various stages. Glass transition temperatures ( T g ) of PSt-Brs and Anti-PSts are determined by differential scanning calorimetry (DSC) analysis. Water contact angle measurement (WCA) is employed for the wettability characterization studies of Anti-PSts. In addition, antibacterial activity of final products against to Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli ) bacteria is elucidated in terms of molecular weight and quaternization reaction time.
{"title":"Study on the Synthesis and Characterization of Antibacterial Polystyrenes","authors":"G. Acik","doi":"10.18596/JOTCSA.547471","DOIUrl":"https://doi.org/10.18596/JOTCSA.547471","url":null,"abstract":"In the present work, a series of quaternized antibacterial polystyrenes (Anti-PSts) with various molecular weights are synthesized and characterized. Initially, ω-bromo end functional polystyrenes with different molecular weights (PSt-Br-1, PSt-Br-2 and PSt-Br-2) are synthesized by atom transfer radical polymerization (ATRP). Then, the ω–bromo functionalities of obtained PSt-Brs are reacted with trimethylamine (TEA) to achieve corresponding antibacterial properties. PSt-Brs and Anti-PSts produced are structurally characterized by Fourier transform infrared spectroscopy (FT-IR), proton nuclear magnetic resonance spectroscopy ( 1 H-NMR), and gel permeation chromatography (GPC) at various stages. Glass transition temperatures ( T g ) of PSt-Brs and Anti-PSts are determined by differential scanning calorimetry (DSC) analysis. Water contact angle measurement (WCA) is employed for the wettability characterization studies of Anti-PSts. In addition, antibacterial activity of final products against to Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli ) bacteria is elucidated in terms of molecular weight and quaternization reaction time.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48604632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The genus Scutellaria L. (Lamiaceae) is represented in Turkey by 16 species, 1 natural hybrid, 38 taxa, 16 being endemic in Turkey (1,2) . Hydrodistilled essential oils of the aerial parts of Scutellaria altissima L. and Scutellaria orientalis L. subsp. pinnatifida Edmondson were analyzed by GC and GC-MS systems, simultaneously. The oil of S. altissima contained β-caryophyllene (34.7 %), caryophyll-5-en-12-al (14.4%), linalool (14.3%) and hexadecanoic acid (7.1%) as main constituents. The oil of S. orientalis L. subsp. pinnatifida was characterized by the occurrence of germacrene D (56.9%), β-caryophyllene (10.5%) and bicyclogermacrene (10.1%) as major components. To the best of our knowledge, this is the first report on the GC and GC/MS determination of the essential oil composition of the S. altissima and S. orientalis subsp. pinnatifida species studied.
{"title":"Essential Oil Composition Of Two Scutellaria species from Tokat, Turkey","authors":"M. Kürkçüoǧlu, Gülsüm Yıldız, Y. Köse","doi":"10.18596/JOTCSA.466906","DOIUrl":"https://doi.org/10.18596/JOTCSA.466906","url":null,"abstract":"The genus Scutellaria L. (Lamiaceae) is represented in Turkey by 16 species, 1 natural hybrid, 38 taxa, 16 being endemic in Turkey (1,2) . Hydrodistilled essential oils of the aerial parts of Scutellaria altissima L. and Scutellaria orientalis L. subsp. pinnatifida Edmondson were analyzed by GC and GC-MS systems, simultaneously. The oil of S. altissima contained β-caryophyllene (34.7 %), caryophyll-5-en-12-al (14.4%), linalool (14.3%) and hexadecanoic acid (7.1%) as main constituents. The oil of S. orientalis L. subsp. pinnatifida was characterized by the occurrence of germacrene D (56.9%), β-caryophyllene (10.5%) and bicyclogermacrene (10.1%) as major components. To the best of our knowledge, this is the first report on the GC and GC/MS determination of the essential oil composition of the S. altissima and S. orientalis subsp. pinnatifida species studied.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43362373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, it is aimed to define the properties which determine their effects on the quality and health of five different kinds of seed oils produced by the cold pressed extraction method. The cold pressed seed oils known as coffee bean, pomegranate, cherry, apricot, and fig kernels which are produced in the domestic market of Turkey were bought to determine the quality characteristics such as peroxide values, free fatty acidity, and UV-specific absorption values, total phenolic compounds and antioxidant activity of these seed oils. When the peroxide values were examined, the highest peroxide value was found in coffee bean oil and the lowest peroxide value was found in pomegranate seed oil. When the free fatty acidity is considered, the number of free fatty acids is ranked from the highest to the lowest as coffee bean oil, fig kernel oil, sour cherry seed oil, pomegranate seed oil, and apricot kernel oil. The K 232 value was found to be the highest in coffee bean oil while it was the lowest in apricot kernel oil. K 270 values were the highest in pomegranate seed and the lowest in the apricot kernel. As seen in the results of the total phenolic compound analysis performed to recognize the effects on health, this value was highest in coffee bean oil, followed by apricot kernel oil, fig kernel oil, pomegranate seed oil, and sour cherry seed oil. When the results antioxidant activity analysis were examined, the antioxidant activity of apricot kernel oil was found to be the lowest, while this value of fig kernel oil was found to be the highest. According to the analysis of variance, these differences were statistically found to be significant. In addition, these values were compared with the studies in the literature and evaluated according to the legal limits. These products sold on the grounds that they have beneficial effects on health in the market should be implemented with more stringent procedures to be audited by public institutions and legal regulations should be supported by further scientific studies.
{"title":"The Comparison of the Quality Properties of Some Commercial Cold Pressed Seed Oils","authors":"Hazal Özyurt","doi":"10.18596/JOTCSA.496458","DOIUrl":"https://doi.org/10.18596/JOTCSA.496458","url":null,"abstract":"In this study, it is aimed to define the properties which determine their effects on the quality and health of five different kinds of seed oils produced by the cold pressed extraction method. The cold pressed seed oils known as coffee bean, pomegranate, cherry, apricot, and fig kernels which are produced in the domestic market of Turkey were bought to determine the quality characteristics such as peroxide values, free fatty acidity, and UV-specific absorption values, total phenolic compounds and antioxidant activity of these seed oils. When the peroxide values were examined, the highest peroxide value was found in coffee bean oil and the lowest peroxide value was found in pomegranate seed oil. When the free fatty acidity is considered, the number of free fatty acids is ranked from the highest to the lowest as coffee bean oil, fig kernel oil, sour cherry seed oil, pomegranate seed oil, and apricot kernel oil. The K 232 value was found to be the highest in coffee bean oil while it was the lowest in apricot kernel oil. K 270 values were the highest in pomegranate seed and the lowest in the apricot kernel. As seen in the results of the total phenolic compound analysis performed to recognize the effects on health, this value was highest in coffee bean oil, followed by apricot kernel oil, fig kernel oil, pomegranate seed oil, and sour cherry seed oil. When the results antioxidant activity analysis were examined, the antioxidant activity of apricot kernel oil was found to be the lowest, while this value of fig kernel oil was found to be the highest. According to the analysis of variance, these differences were statistically found to be significant. In addition, these values were compared with the studies in the literature and evaluated according to the legal limits. These products sold on the grounds that they have beneficial effects on health in the market should be implemented with more stringent procedures to be audited by public institutions and legal regulations should be supported by further scientific studies.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45668838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The remediation of cadmium and lead ions from their respective aqueous solutions was carried out with the use of metal-organic frameworks (MOFs) developed from copper and zinc with benzene-1,4-dicarboxylic acid (BDC). The experimental adsorption process was done in batches to determine the equilibrium characteristics, thermodynamics and kinetics of the sorption processes. The result was then tested using Langmuir, Freundlich, and Temkin isotherm equations with Langmuir being the best fitted isotherm, while the kinetics isotherm used were pseudo first order and pseudo second order. The result obtained shows that the MOFs are great potential adsorbent for the studied metals.
{"title":"METAL-ORGANIC FRAMEWORKS (MOFs) DERIVED FROM CARBOXYLATE LIGAND AS POTENTIAL MATERIALS FOR REMEDIATION OF Cu (II) AND Pb (II) FROM AQUEOUS SOLUTION","authors":"H. Okoro, Oluwaseyi Ayika, A. Tella, J. Ngila","doi":"10.18596/JOTCSA.454010","DOIUrl":"https://doi.org/10.18596/JOTCSA.454010","url":null,"abstract":"The remediation of cadmium and lead ions from their respective aqueous solutions was carried out with the use of metal-organic frameworks (MOFs) developed from copper and zinc with benzene-1,4-dicarboxylic acid (BDC). The experimental adsorption process was done in batches to determine the equilibrium characteristics, thermodynamics and kinetics of the sorption processes. The result was then tested using Langmuir, Freundlich, and Temkin isotherm equations with Langmuir being the best fitted isotherm, while the kinetics isotherm used were pseudo first order and pseudo second order. The result obtained shows that the MOFs are great potential adsorbent for the studied metals.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45493816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Schiff bases have been used in biological processes and as chelating agents for several decades. This work presents the synthesis and characterization of compound, N,N’-Bis(3-tert-Butyl-5-methylsalicylidene)-1,2-diamino phenylene as the Schiff base derivative with the reaction of an aromatic aldehyde derivative and o-phenylenediamine. The spectroscopic properties of the compound were examined by FT-IR, 1 H NMR, 13 C NMR, MS and elemental analyses. The molecular structure of the compound was also confirmed using X-ray single-crystal data. And also theoretical calculations were obtained by using Density Functional Theory (DFT) methods. T he structural parameters were calculated by using DFT/B3LYP/6-31G(d,p) basis set in ground state. Molecular Electrostatic Potential (MEP) map and the frontier molecular orbitals (HOMO-LUMO) of the compound were created by using the optimized structures. The results of theoretical study using the DFT method at the B3LYP/6–31G(d,p) level are in good agreement with the experimental data . Hirshfeld surface analyses and two dimensional fingerprint plots were used to analyse the intermolecular interactions present in the crystal, indicating that the most important contributions for the crystal packing are from H ∙∙∙ H (71.2%), H ∙∙∙ C/C ∙∙∙ H (18.7%), C ∙∙∙ C (4.8%) and H ∙∙∙ N/N ∙∙∙ H (2.7%) interactions.
{"title":"Synthesis, molecular structure, Hirshfeld surface analysis, spectroscopic and computational studies (DFT) of 6,6'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))bis(2-(tert-butyl)-4-methylphenol)","authors":"P. Şen, S. Kansız, N. Dege","doi":"10.18596/JOTCSA.483143","DOIUrl":"https://doi.org/10.18596/JOTCSA.483143","url":null,"abstract":"Schiff bases have been used in biological processes and as chelating agents for several decades. This work presents the synthesis and characterization of compound, N,N’-Bis(3-tert-Butyl-5-methylsalicylidene)-1,2-diamino phenylene as the Schiff base derivative with the reaction of an aromatic aldehyde derivative and o-phenylenediamine. The spectroscopic properties of the compound were examined by FT-IR, 1 H NMR, 13 C NMR, MS and elemental analyses. The molecular structure of the compound was also confirmed using X-ray single-crystal data. And also theoretical calculations were obtained by using Density Functional Theory (DFT) methods. T he structural parameters were calculated by using DFT/B3LYP/6-31G(d,p) basis set in ground state. Molecular Electrostatic Potential (MEP) map and the frontier molecular orbitals (HOMO-LUMO) of the compound were created by using the optimized structures. The results of theoretical study using the DFT method at the B3LYP/6–31G(d,p) level are in good agreement with the experimental data . Hirshfeld surface analyses and two dimensional fingerprint plots were used to analyse the intermolecular interactions present in the crystal, indicating that the most important contributions for the crystal packing are from H ∙∙∙ H (71.2%), H ∙∙∙ C/C ∙∙∙ H (18.7%), C ∙∙∙ C (4.8%) and H ∙∙∙ N/N ∙∙∙ H (2.7%) interactions.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44691700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Özkorucuklu, Besnik Uka, Gizem Yıldırım Baştemur
In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each sample. Validation parameters were studied to show the correctness, sensitivity, and consistency of the method developed for the cephalosporins. It was concluded that disposable pencil graphite electrode could be used effectively in the determination of cephalosporins. The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively. The analysis of these compounds in pharmaceutical formulations and biological samples was carried out at defined optimum conditions. The recovery values were around 100%.
{"title":"Voltammetric Analysis of Cephalexin and Cefazoline in Pharmaceutical Formulation and Biological Samples","authors":"S. Özkorucuklu, Besnik Uka, Gizem Yıldırım Baştemur","doi":"10.18596/JOTCSA.469028","DOIUrl":"https://doi.org/10.18596/JOTCSA.469028","url":null,"abstract":"In this study, the electrochemical behaviors of cephalexin and cefazoline on disposable pencil graphite electrode were investigated in phosphate buffer at pH of 4.5 to 6.0 by differential pulse voltammetry. Sample analysis was performed in phosphate buffer at the optimum medium determined for each sample. Validation parameters were studied to show the correctness, sensitivity, and consistency of the method developed for the cephalosporins. It was concluded that disposable pencil graphite electrode could be used effectively in the determination of cephalosporins. The limits of detection (S/N=3) were found to be 0.115 mM and 0.303 mM, for cephalexin and cefazoline, respectively. The analysis of these compounds in pharmaceutical formulations and biological samples was carried out at defined optimum conditions. The recovery values were around 100%.","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42610048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present work consists the elaboration and the rheological behaviors of nanocomposite (NGTHTPTBAE/MDA/TSP) in the presence of the epoxy resin nanoglycidyl trihydrazine 4.4.4-tripropoxy tribisphenol A of ethylene (NGTHTPTBAE), methylene dianiline (MDA) and trisodium phosphate (TSP) used as filler. Furthermore, we have studied the performance of nanocomposites (NGTHTPTBAE/MDA/TSP) crosslinked by methylene dianiline and formulated by trisodium phosphate at different percentages. Then, the storage modulus G' and the loss modulus G'' (or tanδ = G''/G') are established as a function of the temperature. From these dependencies, we determined the glass transition temperature or tanδ maximum. Moreover, tan δ > 1 for liquid-like materials and it becomes lower than unity for solid-like materials. Finally, the dispersion of the trisodium phosphate incorporated into various prepared nanocomposite (NGTHTPTBAE/MDA/TSP) was determined using the scanning electron microscope (SEM).
{"title":"Morphological and rheological study of the epoxy polymer and their nanocomposite (NGTHTPTBAE/MDA/TSP) crosslinked by methylene dianiline and formulated by trisodium phosphate","authors":"R. Hsissou, M. Berradi, M. E. Bouchti, A. Harfi","doi":"10.18596/JOTCSA.477191","DOIUrl":"https://doi.org/10.18596/JOTCSA.477191","url":null,"abstract":"The present work consists the elaboration and the rheological behaviors of nanocomposite (NGTHTPTBAE/MDA/TSP) in the presence of the epoxy resin nanoglycidyl trihydrazine 4.4.4-tripropoxy tribisphenol A of ethylene (NGTHTPTBAE), methylene dianiline (MDA) and trisodium phosphate (TSP) used as filler. Furthermore, we have studied the performance of nanocomposites (NGTHTPTBAE/MDA/TSP) crosslinked by methylene dianiline and formulated by trisodium phosphate at different percentages. Then, the storage modulus G' and the loss modulus G'' (or tanδ = G''/G') are established as a function of the temperature. From these dependencies, we determined the glass transition temperature or tanδ maximum. Moreover, tan δ > 1 for liquid-like materials and it becomes lower than unity for solid-like materials. Finally, the dispersion of the trisodium phosphate incorporated into various prepared nanocomposite (NGTHTPTBAE/MDA/TSP) was determined using the scanning electron microscope (SEM).","PeriodicalId":17402,"journal":{"name":"Journal of the Turkish Chemical Society, Section A: Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43722744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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