Ranjitha Krishnegowda, S. Pradhan, A. Gosavi, N. Deshmukh
Background: Alopecia is one of the most common reasons for consulting dermatologists, and the clinical diagnosis can become confusing. In light of the inclination of patients and doctors toward non-invasive diagnosis, along with the vogue of non-invasive diagnostic modalities, trichoscopy has become a promising tool. Objectives: To study various dermoscopic patterns of alopecia. Methods: After obtaining informed consent, this cross-sectional study was conducted among 100 patients with alopecia attending a tertiary health care center. A detailed history and clinical photographs were taken. Relevant investigations were done whenever indicated. Dermoscopy was done using illuco IDS- 1100 with 10x magnification. Statistical analysis used: Data was analyzed using SPSS 22 version software. The chi-square test, Kolmogorov-Smirnov test, and Shapiro-Wilk test was used for assessment with a significant P-value of < 0.05. Kappa statistics were used to assess agreement between the two modalities. Results: Overall, vellus hair (65%) and yellow dots (65%) were the most common findings among all types of alopecia. The most common findings on trichoscopy in androgenetic alopecia were vellus hair (90.48%); in alopecia areata, vellus hair, and exclamation mark hair (86.67% each); in tinea capitis, corkscrew hair, and black dots; and in trichotillomania, splaying of hair. Discoid Lupus erythematosus had absent follicular opening, scaling, and perifollicular pigmentation. Clinical and dermoscopic diagnoses were significantly associated with a kappa agreement of 0.776 (i.e., substantial agreement). Out of 15 cases of difficult-to-diagnose alopecia, further investigations showed that dermoscopic diagnosis was accurate in 7 cases (46.67%). Conclusions: Trichoscopy is a reliable, non-invasive, and faster method of diagnosis in ambiguous cases of alopecia.
{"title":"Utility of Trichoscopy in Various Types of Alopecia - A Cross-Sectional Study","authors":"Ranjitha Krishnegowda, S. Pradhan, A. Gosavi, N. Deshmukh","doi":"10.5812/jssc-133045","DOIUrl":"https://doi.org/10.5812/jssc-133045","url":null,"abstract":"Background: Alopecia is one of the most common reasons for consulting dermatologists, and the clinical diagnosis can become confusing. In light of the inclination of patients and doctors toward non-invasive diagnosis, along with the vogue of non-invasive diagnostic modalities, trichoscopy has become a promising tool. Objectives: To study various dermoscopic patterns of alopecia. Methods: After obtaining informed consent, this cross-sectional study was conducted among 100 patients with alopecia attending a tertiary health care center. A detailed history and clinical photographs were taken. Relevant investigations were done whenever indicated. Dermoscopy was done using illuco IDS- 1100 with 10x magnification. Statistical analysis used: Data was analyzed using SPSS 22 version software. The chi-square test, Kolmogorov-Smirnov test, and Shapiro-Wilk test was used for assessment with a significant P-value of < 0.05. Kappa statistics were used to assess agreement between the two modalities. Results: Overall, vellus hair (65%) and yellow dots (65%) were the most common findings among all types of alopecia. The most common findings on trichoscopy in androgenetic alopecia were vellus hair (90.48%); in alopecia areata, vellus hair, and exclamation mark hair (86.67% each); in tinea capitis, corkscrew hair, and black dots; and in trichotillomania, splaying of hair. Discoid Lupus erythematosus had absent follicular opening, scaling, and perifollicular pigmentation. Clinical and dermoscopic diagnoses were significantly associated with a kappa agreement of 0.776 (i.e., substantial agreement). Out of 15 cases of difficult-to-diagnose alopecia, further investigations showed that dermoscopic diagnosis was accurate in 7 cases (46.67%). Conclusions: Trichoscopy is a reliable, non-invasive, and faster method of diagnosis in ambiguous cases of alopecia.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"68 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130040207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Fernandes, Ana Kívia Silva Matias, Graziele Áquila de Souza Brandão, L. Fraga, Alvaro Varao, Carlos Dornels Freire de Souza
: The relationship between atopic and allergic contact dermatitis is often discussed, especially in children. The damaged skin barrier in atopic patients can make the skin more permeable to exogenous agents and increase the risk of triggering contact dermatitis. Topical treatment of atopic dermatitis is associated with skin sensitization to several drugs, including antiseptics, emollients, and topical corticosteroids. The early onset of atopic dermatitis, as in the case reported here, the severity of the disease, and IgE-mediated sensitization are identified as the main risk factors associated with sensitization to topical treatments for atopic dermatitis. We report a two-year-old child with a previous diagnosis of atopic dermatitis, whose condition was aggravated by inadequate medical treatment.
{"title":"Iatrogenic Contact Dermatitis in a Patient with Atopic Dermatitis","authors":"T. Fernandes, Ana Kívia Silva Matias, Graziele Áquila de Souza Brandão, L. Fraga, Alvaro Varao, Carlos Dornels Freire de Souza","doi":"10.5812/jssc-126399","DOIUrl":"https://doi.org/10.5812/jssc-126399","url":null,"abstract":": The relationship between atopic and allergic contact dermatitis is often discussed, especially in children. The damaged skin barrier in atopic patients can make the skin more permeable to exogenous agents and increase the risk of triggering contact dermatitis. Topical treatment of atopic dermatitis is associated with skin sensitization to several drugs, including antiseptics, emollients, and topical corticosteroids. The early onset of atopic dermatitis, as in the case reported here, the severity of the disease, and IgE-mediated sensitization are identified as the main risk factors associated with sensitization to topical treatments for atopic dermatitis. We report a two-year-old child with a previous diagnosis of atopic dermatitis, whose condition was aggravated by inadequate medical treatment.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132492719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discrepancies in the Guidelines for Management of STIs","authors":"M. Sankaranantham","doi":"10.5812/jssc-134932","DOIUrl":"https://doi.org/10.5812/jssc-134932","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132552320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Garcia Garay, L. D. Gutierrez-Castañeda, Jose David Tovar Parra
Background: The solute carrier family 45-member 2 (SLC45A2) gene, located on chromosome 5p13.2, is involved in melanin biosynthesis. Single-nucleotide variants (SNVs) in this gene are associated with skin, eye, and hair color variations in the population. SNVs p.L374F (C/T) and p.E272K (C/G) are additionally associated with protection against melanoma. Objectives: This study aimed to evaluate the association of SNVs p.L374F and p.E272K with the development of melanoma in a sample of individuals from Bogotá, Colombia. Methods: In this case-control study, DNA samples were obtained from individuals after signing an informed consent form. Genotyping was performed by real-time polymerase chain reaction high-resolution melting (PCR-HRM). Results: Phototype II was found in 19% of the subjects, phototype III in 70%, and phototype IV in 11%. Eighty percent of the subjects had brown eyes and dark brown hair color. Both SNVs were in Hardy-Weinberg equilibrium. The p.Glu272Lys variant was found to be a protective factor for melanoma, while the p.Phe374Leu variant was found to be a risk factor. The study also found that a CG haplotype was a risk factor for melanoma [odds ratio (OR), 2.75; 95% CI, 1.22 - 6.22; P = 0.021]. The study also found a strong correlation between variants and phototypes, as well as the sex of the patients. The study also analyzed the impact of these variants on the protein structure and found that the p.Phe374Leu variant has a probable pathogenic effect on the function of the protein. Conclusions: The frequencies found for the SLC45A2 gene variants are consistent with other studies conducted in the Latin American population, where the predominant phototypes are II and III. The CG haplotype is associated with a higher risk of melanoma.
{"title":"Solute Carrier Family 45 Member 2 Germline Variants in the Colombian Population with Melanoma","authors":"Diana Garcia Garay, L. D. Gutierrez-Castañeda, Jose David Tovar Parra","doi":"10.5812/jssc-135009","DOIUrl":"https://doi.org/10.5812/jssc-135009","url":null,"abstract":"Background: The solute carrier family 45-member 2 (SLC45A2) gene, located on chromosome 5p13.2, is involved in melanin biosynthesis. Single-nucleotide variants (SNVs) in this gene are associated with skin, eye, and hair color variations in the population. SNVs p.L374F (C/T) and p.E272K (C/G) are additionally associated with protection against melanoma. Objectives: This study aimed to evaluate the association of SNVs p.L374F and p.E272K with the development of melanoma in a sample of individuals from Bogotá, Colombia. Methods: In this case-control study, DNA samples were obtained from individuals after signing an informed consent form. Genotyping was performed by real-time polymerase chain reaction high-resolution melting (PCR-HRM). Results: Phototype II was found in 19% of the subjects, phototype III in 70%, and phototype IV in 11%. Eighty percent of the subjects had brown eyes and dark brown hair color. Both SNVs were in Hardy-Weinberg equilibrium. The p.Glu272Lys variant was found to be a protective factor for melanoma, while the p.Phe374Leu variant was found to be a risk factor. The study also found that a CG haplotype was a risk factor for melanoma [odds ratio (OR), 2.75; 95% CI, 1.22 - 6.22; P = 0.021]. The study also found a strong correlation between variants and phototypes, as well as the sex of the patients. The study also analyzed the impact of these variants on the protein structure and found that the p.Phe374Leu variant has a probable pathogenic effect on the function of the protein. Conclusions: The frequencies found for the SLC45A2 gene variants are consistent with other studies conducted in the Latin American population, where the predominant phototypes are II and III. The CG haplotype is associated with a higher risk of melanoma.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132299316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Psoriasis is a chronic auto-inflammatory condition. Treatment modalities include methotrexate (MTX) and apremilast (APL). Although the efficacy of MTX and APL is well studied, evidence of their superiority of one over the other is lacking. Dermoscopy is helpful in diagnosis and treatment evaluation. Therefore, dermoscopy is utilized to assess the treatment response. Objectives: This study aimed to evaluate dermoscopic assessment in psoriatic lesions treated by MTX and APL and compare their efficacy by calculating the respective Psoriasis Area and Severity Index (PASI) scores and study the effect of MTX and APL on different dermoscopic patterns in psoriasis at different levels of treatment. Methods: This randomized interventional comparative study was conducted in a tertiary care hospital. A total of 98 patients were randomly divided into two groups of 50 and 48 patients, given oral/intramuscular MTX 7.5 mg once weekly and APL 30 mg twice daily for 3 months, respectively. The patients were assessed clinically and dermoscopically using a videodermoscope, and comparisons were performed between the two groups. The PASI score was calculated and evaluated. Results: The PASI score was reduced by 83% and 65% from the baseline in MTX and APL groups, respectively. The patients with patchy (61.5%) and minimal (23%) patterns of vessels and red dots (92.3%) showed faster achievement of PASI-100. However, the patients with a regular distribution of vessels and globular vessels failed to obtain PASI-100, suggesting a poor response to treatment. Conclusions: Vascular structures play a significant role in the diagnosis and prediction of the treatment response. Particular patterns and type vessels under dermoscopy can give a hint about choosing appropriate drugs for psoriasis.
背景:银屑病是一种慢性自身炎症性疾病。治疗方式包括甲氨蝶呤(MTX)和阿普米司特(APL)。虽然MTX和APL的疗效已经得到了很好的研究，但缺乏证据表明它们之间的优势。皮肤镜检查有助于诊断和治疗评价。因此，皮肤镜被用来评估治疗反应。目的:本研究旨在通过计算各自的银屑病面积和严重程度指数(Psoriasis Area and Severity Index, PASI)评分，评价MTX和APL治疗银屑病病变的皮镜评价，比较其疗效，研究MTX和APL对不同治疗水平银屑病不同皮镜模式的影响。方法:在某三级医院进行随机介入比较研究。98例患者随机分为50例和48例两组，分别给予口服/肌注MTX 7.5 mg，每周1次，APL 30 mg，每天2次，疗程3个月。使用视频皮肤镜对患者进行临床和皮肤镜检查，并对两组患者进行比较。计算并评估PASI评分。结果:MTX组和APL组的PASI评分分别比基线降低了83%和65%。斑块型(61.5%)和极小型(23%)血管和红点型(92.3%)患者达到PASI-100的速度更快。然而，血管和球状血管分布规律的患者未能达到PASI-100，提示治疗反应较差。结论:血管结构对诊断和预测治疗效果有重要作用。皮肤镜下特定的血管形态和类型可以提示选择合适的治疗银屑病的药物。
{"title":"Dermoscopic Prediction of Therapeutic Response in Psoriatic Lesions Treated with Methotrexate and Apremilast: An Observational Study on Skin Color","authors":"Sankappanavara V Smitha, B. Ankad","doi":"10.5812/jssc-134276","DOIUrl":"https://doi.org/10.5812/jssc-134276","url":null,"abstract":"Background: Psoriasis is a chronic auto-inflammatory condition. Treatment modalities include methotrexate (MTX) and apremilast (APL). Although the efficacy of MTX and APL is well studied, evidence of their superiority of one over the other is lacking. Dermoscopy is helpful in diagnosis and treatment evaluation. Therefore, dermoscopy is utilized to assess the treatment response. Objectives: This study aimed to evaluate dermoscopic assessment in psoriatic lesions treated by MTX and APL and compare their efficacy by calculating the respective Psoriasis Area and Severity Index (PASI) scores and study the effect of MTX and APL on different dermoscopic patterns in psoriasis at different levels of treatment. Methods: This randomized interventional comparative study was conducted in a tertiary care hospital. A total of 98 patients were randomly divided into two groups of 50 and 48 patients, given oral/intramuscular MTX 7.5 mg once weekly and APL 30 mg twice daily for 3 months, respectively. The patients were assessed clinically and dermoscopically using a videodermoscope, and comparisons were performed between the two groups. The PASI score was calculated and evaluated. Results: The PASI score was reduced by 83% and 65% from the baseline in MTX and APL groups, respectively. The patients with patchy (61.5%) and minimal (23%) patterns of vessels and red dots (92.3%) showed faster achievement of PASI-100. However, the patients with a regular distribution of vessels and globular vessels failed to obtain PASI-100, suggesting a poor response to treatment. Conclusions: Vascular structures play a significant role in the diagnosis and prediction of the treatment response. Particular patterns and type vessels under dermoscopy can give a hint about choosing appropriate drugs for psoriasis.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"53 36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123910879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sohrab Moradi, M. Nilforoushzadeh, J. Zargan, S. Nazarian, P. Brouki Milan
Background: Nano-scaffolds loaded with bioactive compounds such as ZnO nanoparticles (ZnO-NPs), as tissue-engineered artificial skin grafts, can be a suitable substitute for extracellular matrix and greatly contribute to accelerating chronic wound treatment by decreasing the chance of bacterial infection. Methods: Silk fibroin nanofiber was fabricated by using electrospinning and three-dimensional porous hybrids (3DPH) nano-scaffold with composite of sodium alginate/ZnO-NPs solution and silk fibroin electrospun nanofibers by adopting freeze-drying method. Successful configuration of nanofibers and porous nano-scaffolds were confirmed using field emission scanning electron microscopy (FE-SEM). Antimicrobial activity, cell attachment, and cytotoxicity evaluation of scaffolds were performed by employing disk diffusion method, L929 cell culture, and MTT assay, respectively. Results: Antibacterial analysis of 3DPH nano-scaffolds revealed their appropriate antibacterial activity against the Staphylococcus aureus and the Escherichia coli bacteria. Furthermore, the results from cytotoxicity and cell adhesion analyses indicated the appropriate cell attachment, viability, and proliferation on the silk fibroin nanofibers and 3DPH nano-scaffold, which are fundamental for wound healing and skin dermo-epidermal grafts. Conclusions: In sum, silk fibroin nanofiber as an epidermal graft and 3DPH nano-scaffold loaded with ZnO-NPs as a dermal graft were fabricated. Moreover, 1.5% (w/v) concentrations of ZnO-NPs were selected and incorporated into the 3DPH nano-scaffold. Considering the promising results of biological analyses, the nanofibrous and 3DPH nano-scaffolds composite may have been suitable for skin dermo-epidermal grafts and skin regeneration.
{"title":"A Novel Composite Nano-scaffold with Potential Usage as Skin Dermo-epidermal Grafts for Chronic Wound Treatment","authors":"Sohrab Moradi, M. Nilforoushzadeh, J. Zargan, S. Nazarian, P. Brouki Milan","doi":"10.5812/jssc-133976","DOIUrl":"https://doi.org/10.5812/jssc-133976","url":null,"abstract":"Background: Nano-scaffolds loaded with bioactive compounds such as ZnO nanoparticles (ZnO-NPs), as tissue-engineered artificial skin grafts, can be a suitable substitute for extracellular matrix and greatly contribute to accelerating chronic wound treatment by decreasing the chance of bacterial infection. Methods: Silk fibroin nanofiber was fabricated by using electrospinning and three-dimensional porous hybrids (3DPH) nano-scaffold with composite of sodium alginate/ZnO-NPs solution and silk fibroin electrospun nanofibers by adopting freeze-drying method. Successful configuration of nanofibers and porous nano-scaffolds were confirmed using field emission scanning electron microscopy (FE-SEM). Antimicrobial activity, cell attachment, and cytotoxicity evaluation of scaffolds were performed by employing disk diffusion method, L929 cell culture, and MTT assay, respectively. Results: Antibacterial analysis of 3DPH nano-scaffolds revealed their appropriate antibacterial activity against the Staphylococcus aureus and the Escherichia coli bacteria. Furthermore, the results from cytotoxicity and cell adhesion analyses indicated the appropriate cell attachment, viability, and proliferation on the silk fibroin nanofibers and 3DPH nano-scaffold, which are fundamental for wound healing and skin dermo-epidermal grafts. Conclusions: In sum, silk fibroin nanofiber as an epidermal graft and 3DPH nano-scaffold loaded with ZnO-NPs as a dermal graft were fabricated. Moreover, 1.5% (w/v) concentrations of ZnO-NPs were selected and incorporated into the 3DPH nano-scaffold. Considering the promising results of biological analyses, the nanofibrous and 3DPH nano-scaffolds composite may have been suitable for skin dermo-epidermal grafts and skin regeneration.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122527018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Pearl: A Fast and Simple Method of Cauterizing Viral Warts with Trichloroacetic Acid","authors":"M. Mukhtar, N. Mukhtar","doi":"10.5812/jssc-130001","DOIUrl":"https://doi.org/10.5812/jssc-130001","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132959916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Fatemi, Farahnaz Safaei, Pardis Ketabi Moghadam, P. Taheri
: Pyoderma gangrenosum (PG) is a relatively uncommon disorder associated with autoimmune and inflammatory conditions, including inflammatory bowel disease (IBD). PG’s prevalence ranges from 0.4 - 2.6% in patients with IBD. We describe a 34-year-old man with ulcerative colitis (UC) who was referred to our center with some small follicular and pustular lesions rapidly progressing into a painful necrotic ulcer in the right axilla. The ulcer was not responsive to broad spectrum antibiotics and topical cytotoxic agents like tacrolimus. Finally, a dramatic response was observed after initiating anti-tumor necrosis factor (anti-TNF) treatment with infliximab (10 mg/kg) within a week. A significant reduction in size and necrotic tissue was achieved one month after the index date of the prescription of infliximab. A 2-month follow-up of the patient revealed complete healing of the lesion.
{"title":"Dramatic Response of Rapid Progressive Atypical Pyoderma Gangrenosum to Infliximab in a Patient with Ulcerative Colitis","authors":"R. Fatemi, Farahnaz Safaei, Pardis Ketabi Moghadam, P. Taheri","doi":"10.5812/jssc-131970","DOIUrl":"https://doi.org/10.5812/jssc-131970","url":null,"abstract":": Pyoderma gangrenosum (PG) is a relatively uncommon disorder associated with autoimmune and inflammatory conditions, including inflammatory bowel disease (IBD). PG’s prevalence ranges from 0.4 - 2.6% in patients with IBD. We describe a 34-year-old man with ulcerative colitis (UC) who was referred to our center with some small follicular and pustular lesions rapidly progressing into a painful necrotic ulcer in the right axilla. The ulcer was not responsive to broad spectrum antibiotics and topical cytotoxic agents like tacrolimus. Finally, a dramatic response was observed after initiating anti-tumor necrosis factor (anti-TNF) treatment with infliximab (10 mg/kg) within a week. A significant reduction in size and necrotic tissue was achieved one month after the index date of the prescription of infliximab. A 2-month follow-up of the patient revealed complete healing of the lesion.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116160971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modified Hypodermic Needle for Injection into the Concha and Fossa of the Pinna","authors":"M. Mukhtar, Poonam Tapsale","doi":"10.5812/jssc-130360","DOIUrl":"https://doi.org/10.5812/jssc-130360","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115544680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shashank Bansod, A. Kerure, Nikita S. Deshmukh, Aseem Sharma
: Hair transplantation is a physically and mentally demanding field for surgeons. In order to cope with demands, physical and mental fitness is required. Indian ergonomics or yoga asanas serve this purpose fully without taking a heavy toll on the body.
{"title":"Yoga: An Indian Ergonomic Tool to Enhance Productivity of Hair Transplant Surgeons","authors":"Shashank Bansod, A. Kerure, Nikita S. Deshmukh, Aseem Sharma","doi":"10.5812/jssc-122771","DOIUrl":"https://doi.org/10.5812/jssc-122771","url":null,"abstract":": Hair transplantation is a physically and mentally demanding field for surgeons. In order to cope with demands, physical and mental fitness is required. Indian ergonomics or yoga asanas serve this purpose fully without taking a heavy toll on the body.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132086042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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