Background: Interferons are generally prescribed in multiple sclerosis (MS) treatment. This study was done to investigate the severity and type of skin side effects of interferon beta (IFNβ) in patients with MS. Methods: This was a cross-sectional descriptive study on the patients with MS taking IFNβ medication referred to Baqiyatullah Hospital in 2021 - 22. The sample size was 322, and the sampling method was census. Data were documented in a checklist, and analyses were performed by SPSS software version 24 at a significance level of 0.05. Result: About 46% of patients had no skin complications. The erythema at the injection site was the commonest skin complication (45.2%). The hair loss severity after treatment had a statistically significant increase than before (P < 0.001). If the severity of the patient's current disease was moderate, the estimated odds of developing the erythema compared to no complication was 2.60 times higher than the patient with mild current severity of the disease (P = 0.003), and if the severity of the current disease was moderate, the estimated odds of developing erythema + eczema than no complications was 7.70 times higher than the patient with the current severity of the mild disease (P = 0.001). Conclusions: The most important skin complications MS patients experience following the use of IFNβ are injection site skin reactions and erythema. Hair loss increased in MS patients after IFNβ treatment. Prospective studies on the procedure of hair loss after treatment with IFNβ in MS patients are recommended.
{"title":"Skin Complications Associated with Interferon-β Treatment in Patients with Multiple Sclerosis, Tehran in 2021 - 2","authors":"Fakhri Allahyari, Esmat Davoudi-Monfared, Hamideh Molaei, Fateme Shahabi, Davoud Tanbakuchi, Mohsen Shahrivar","doi":"10.5812/jssc-137862","DOIUrl":"https://doi.org/10.5812/jssc-137862","url":null,"abstract":"Background: Interferons are generally prescribed in multiple sclerosis (MS) treatment. This study was done to investigate the severity and type of skin side effects of interferon beta (IFNβ) in patients with MS. Methods: This was a cross-sectional descriptive study on the patients with MS taking IFNβ medication referred to Baqiyatullah Hospital in 2021 - 22. The sample size was 322, and the sampling method was census. Data were documented in a checklist, and analyses were performed by SPSS software version 24 at a significance level of 0.05. Result: About 46% of patients had no skin complications. The erythema at the injection site was the commonest skin complication (45.2%). The hair loss severity after treatment had a statistically significant increase than before (P < 0.001). If the severity of the patient's current disease was moderate, the estimated odds of developing the erythema compared to no complication was 2.60 times higher than the patient with mild current severity of the disease (P = 0.003), and if the severity of the current disease was moderate, the estimated odds of developing erythema + eczema than no complications was 7.70 times higher than the patient with the current severity of the mild disease (P = 0.001). Conclusions: The most important skin complications MS patients experience following the use of IFNβ are injection site skin reactions and erythema. Hair loss increased in MS patients after IFNβ treatment. Prospective studies on the procedure of hair loss after treatment with IFNβ in MS patients are recommended.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127375847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Today, individuals tend to use natural products instead of synthetic additives in many areas. The hazelnut tree produces many by-products and fruit. Nuts and their by-products are rich in bioactive compounds. Objectives: This study investigated the biological activities of water and ethanol extracts obtained from hazelnut and its waste products to determine their potential usage in the cosmetic industry. Methods: In this experimental study, disc diffusion test, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), or minimum fungicidal concentration (MFC) were applied to evaluate the antimicrobial potential of the extracts. The sun protection factor (SPF) of the extracts and commercial cream + extract mixtures was determined in vitro. In addition, antimicrobial cream formulations containing hazelnut extracts and Limosilactobacillus fermentum MA-7 probiotic candidate lactic acid bacteria from human milk were developed for the pharmaceutical industry to prevent infections. The good diffusion test was applied against test microorganisms to evaluate antimicrobial activity. Results: The hazelnut husk methanol extract had the highest inhibition zone diameter (19.41 mm) against Yersinia ruckeri. The MIC, MBC, or MFC of the extracts ranged from 1.25 to > 40 µg/µL. The SPF values of the extracts (range: 6.85-27.64) and commercial cream + extract (range: 11.92-26.28) mixtures were determined in vitro to obtain their potential use in sunscreens. The cream groups containing hazelnut extracts and probiotics showed a high antimicrobial effect on the tested microorganisms. The results of statistical analysis indicated that the cream + extract + probiotic pellet + probiotic supernatant group was statistically significant (P < 0.05) compared to other test groups. Conclusions: The results showed that hazelnuts and their by-products have the potential to be used as a natural source of antimicrobials. Hazelnut and its by-products can be an alternative to synthetic antimicrobials and sunscreens in the cosmetic industry as a natural bioactive substance. In addition, it might contribute to the country’s economy by evaluating hazelnuts and their waste and by-products resulting from their processing in the cosmetic industry.
{"title":"A Natural Additive Alternative to the Cosmetics Industry: Hazelnut and Its Waste Products","authors":"A. Sağlam, Meltem Aşan-Özüsağlam","doi":"10.5812/jssc-137580","DOIUrl":"https://doi.org/10.5812/jssc-137580","url":null,"abstract":"Background: Today, individuals tend to use natural products instead of synthetic additives in many areas. The hazelnut tree produces many by-products and fruit. Nuts and their by-products are rich in bioactive compounds. Objectives: This study investigated the biological activities of water and ethanol extracts obtained from hazelnut and its waste products to determine their potential usage in the cosmetic industry. Methods: In this experimental study, disc diffusion test, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), or minimum fungicidal concentration (MFC) were applied to evaluate the antimicrobial potential of the extracts. The sun protection factor (SPF) of the extracts and commercial cream + extract mixtures was determined in vitro. In addition, antimicrobial cream formulations containing hazelnut extracts and Limosilactobacillus fermentum MA-7 probiotic candidate lactic acid bacteria from human milk were developed for the pharmaceutical industry to prevent infections. The good diffusion test was applied against test microorganisms to evaluate antimicrobial activity. Results: The hazelnut husk methanol extract had the highest inhibition zone diameter (19.41 mm) against Yersinia ruckeri. The MIC, MBC, or MFC of the extracts ranged from 1.25 to > 40 µg/µL. The SPF values of the extracts (range: 6.85-27.64) and commercial cream + extract (range: 11.92-26.28) mixtures were determined in vitro to obtain their potential use in sunscreens. The cream groups containing hazelnut extracts and probiotics showed a high antimicrobial effect on the tested microorganisms. The results of statistical analysis indicated that the cream + extract + probiotic pellet + probiotic supernatant group was statistically significant (P < 0.05) compared to other test groups. Conclusions: The results showed that hazelnuts and their by-products have the potential to be used as a natural source of antimicrobials. Hazelnut and its by-products can be an alternative to synthetic antimicrobials and sunscreens in the cosmetic industry as a natural bioactive substance. In addition, it might contribute to the country’s economy by evaluating hazelnuts and their waste and by-products resulting from their processing in the cosmetic industry.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130811663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Exercise Suitable for Patients with Atopic Dermatitis?","authors":"Yen-Hsiang Wang","doi":"10.5812/jssc-137763","DOIUrl":"https://doi.org/10.5812/jssc-137763","url":null,"abstract":"<jats:p />","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131986604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Psychodermatology is a newly emerging field that associates cosmetic dermatology with psychopathology. It analyzes the psychosocial aspects of beauty and physical attraction. Attractive people, in almost all cultures, are taken positively, and the less attractive ones are ostracized. The social pressure of staying physically attractive may lead to several negative outcomes, which can be placed under a single heading of “charismaphobia” (i.e., the “fear of unattractiveness”). Objectives: The current study aimed to assess the diagnostic aspects of charismaphobia by developing and validating a new scale. Methods: This quantitative study was conducted on 2904 participants in 4 phases. The Charismaphobia Scale was developed and validated through exploratory and confirmatory factor analyses (EFA/CFA). The convergent validity of the scale was determined through generalized anxiety disorder, obsessive-compulsive disorder, and narcissistic personality disorder. Results: The finalized version of the Charismaphobia Scale comprised 19 items in English and reported 4 factors of charismaphobia (i.e., self-exhibition, narcissistic trends, media consumption, and charismaphobic anxiety). Marvelous sampling adequacy (Kaiser-Meyer-Olkin (KMO) = 0.946 and 0.871), highly significant adequacy of correlations between items (P = 0.000), excellent reliability (α = 0.939 and 0.843), strong factor loadings with no cross-loadings, adequate extractions of the items (all between 0.426 and 0.841), highly significant item-scale and item-total correlations (P < 0.001) were observed during the EFA and CFA. The convergent validity of the Charismaphobia Scale was found highly significant with generalized anxiety disorder (r = 0.327; P < 0.001), obsessive-compulsive disorder (r = 0.344; P < 0.001), and narcissistic personality disorder (r = 0.250; P < 0.001). Conclusions: The Charismaphobia Scale was developed and validated for the ease of clinical psychologists and dermatologists to assess the mental conditions underlying common dermatological problems.
{"title":"Charismaphobia: Diagnosis and Measurement of the Psychodermatological Symptoms","authors":"Waqar Husain","doi":"10.5812/jssc-137387","DOIUrl":"https://doi.org/10.5812/jssc-137387","url":null,"abstract":"Background: Psychodermatology is a newly emerging field that associates cosmetic dermatology with psychopathology. It analyzes the psychosocial aspects of beauty and physical attraction. Attractive people, in almost all cultures, are taken positively, and the less attractive ones are ostracized. The social pressure of staying physically attractive may lead to several negative outcomes, which can be placed under a single heading of “charismaphobia” (i.e., the “fear of unattractiveness”). Objectives: The current study aimed to assess the diagnostic aspects of charismaphobia by developing and validating a new scale. Methods: This quantitative study was conducted on 2904 participants in 4 phases. The Charismaphobia Scale was developed and validated through exploratory and confirmatory factor analyses (EFA/CFA). The convergent validity of the scale was determined through generalized anxiety disorder, obsessive-compulsive disorder, and narcissistic personality disorder. Results: The finalized version of the Charismaphobia Scale comprised 19 items in English and reported 4 factors of charismaphobia (i.e., self-exhibition, narcissistic trends, media consumption, and charismaphobic anxiety). Marvelous sampling adequacy (Kaiser-Meyer-Olkin (KMO) = 0.946 and 0.871), highly significant adequacy of correlations between items (P = 0.000), excellent reliability (α = 0.939 and 0.843), strong factor loadings with no cross-loadings, adequate extractions of the items (all between 0.426 and 0.841), highly significant item-scale and item-total correlations (P < 0.001) were observed during the EFA and CFA. The convergent validity of the Charismaphobia Scale was found highly significant with generalized anxiety disorder (r = 0.327; P < 0.001), obsessive-compulsive disorder (r = 0.344; P < 0.001), and narcissistic personality disorder (r = 0.250; P < 0.001). Conclusions: The Charismaphobia Scale was developed and validated for the ease of clinical psychologists and dermatologists to assess the mental conditions underlying common dermatological problems.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134485846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Almheirat, Khadija Kaddar, Lamis Elyamani, S. Dikhaye, N. Zizi
Introduction: Genital ulcers are among the main manifestations of Behçet’s disease (BD); however, large severe acute genital ulcers are not common. Case Presentation: A 29-year-old unmarried woman with a history of recurrent oral aphthae presented with a genital ulcer developed 2 weeks before admission. On clinical examination, there were two large painful ulcerations on the right labia majora, painful oral ulcerations, non-follicular pustules on the face and limbs, and painful edema on the left leg with positive Homan’s sign. The D-dimer level was elevated, and a Doppler ultrasound showed deep venous thrombosis of the right common femoral, femoral, and popliteal veins. The BD was diagnosed according to the International Criteria for Behçet’s Disease. The patient was treated with prednisone 40 mg/day and colchicine 1 mg/day, and the lesions developed well and healed within 2 weeks, leaving scarring lesions in the genital area. Conclusions: Behçet's disease is an important nonvenereal cause of genital ulceration. A high index of suspicion in a patient with mucocutaneous lesions might result in the early diagnosis, management, and prevention of complications.
{"title":"Severe Acute Genital Ulcer: An Unusual Presentation of Behçet’s Disease: A Case Report","authors":"Y. Almheirat, Khadija Kaddar, Lamis Elyamani, S. Dikhaye, N. Zizi","doi":"10.5812/jssc-137491","DOIUrl":"https://doi.org/10.5812/jssc-137491","url":null,"abstract":"Introduction: Genital ulcers are among the main manifestations of Behçet’s disease (BD); however, large severe acute genital ulcers are not common. Case Presentation: A 29-year-old unmarried woman with a history of recurrent oral aphthae presented with a genital ulcer developed 2 weeks before admission. On clinical examination, there were two large painful ulcerations on the right labia majora, painful oral ulcerations, non-follicular pustules on the face and limbs, and painful edema on the left leg with positive Homan’s sign. The D-dimer level was elevated, and a Doppler ultrasound showed deep venous thrombosis of the right common femoral, femoral, and popliteal veins. The BD was diagnosed according to the International Criteria for Behçet’s Disease. The patient was treated with prednisone 40 mg/day and colchicine 1 mg/day, and the lesions developed well and healed within 2 weeks, leaving scarring lesions in the genital area. Conclusions: Behçet's disease is an important nonvenereal cause of genital ulceration. A high index of suspicion in a patient with mucocutaneous lesions might result in the early diagnosis, management, and prevention of complications.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121049512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Context: Functions of melanocytes are supported by many growth factors and cytokines derived from epidermal and dermal cells, especially keratinocytes and fibroblasts. In addition to these skin cells, elastin fibers are thought to be important for regulating melanocyte functions in normal and abnormal skin. However, the role of elastin has not been fully investigated. Recently, the research on the role of elastin in melanocyte functions has greatly increased even in human skin, whereas no full review article on this subject has been presented so far. Thus, the author tried to present a complete review article on this subject in animals and humans. Methods: The author searched the literature on elastin and melanocytes in research databases. Results: Elastin fibers can affect the normal functions of melanoblasts/melanocytes in animals and humans. Moreover, elastin fibers influence melanocyte functions in abnormal skin. In vitiliginous skin, where melanin and melanoblasts/melanocytes are completely lost, elastin fibers are dramatically reduced. However, elastin fibers are completely restored or even increased in the dermis of repigmented skin after phototherapy and/or skin transplantation. Moreover, elastin fibers penetrate the basement membrane of repigmented skin, suggesting a direct contact between dermal elastin fibers and epidermal melanoblasts/melanocytes. Conclusions: Elastin/elastin fibers may control the functions of mammalian melanocytes in normal and abnormal skin.
{"title":"Elastin is Related to Functions of Melanocytes in Normal and Abnormal Skin","authors":"T. Hirobe","doi":"10.5812/jssc-135902","DOIUrl":"https://doi.org/10.5812/jssc-135902","url":null,"abstract":"Context: Functions of melanocytes are supported by many growth factors and cytokines derived from epidermal and dermal cells, especially keratinocytes and fibroblasts. In addition to these skin cells, elastin fibers are thought to be important for regulating melanocyte functions in normal and abnormal skin. However, the role of elastin has not been fully investigated. Recently, the research on the role of elastin in melanocyte functions has greatly increased even in human skin, whereas no full review article on this subject has been presented so far. Thus, the author tried to present a complete review article on this subject in animals and humans. Methods: The author searched the literature on elastin and melanocytes in research databases. Results: Elastin fibers can affect the normal functions of melanoblasts/melanocytes in animals and humans. Moreover, elastin fibers influence melanocyte functions in abnormal skin. In vitiliginous skin, where melanin and melanoblasts/melanocytes are completely lost, elastin fibers are dramatically reduced. However, elastin fibers are completely restored or even increased in the dermis of repigmented skin after phototherapy and/or skin transplantation. Moreover, elastin fibers penetrate the basement membrane of repigmented skin, suggesting a direct contact between dermal elastin fibers and epidermal melanoblasts/melanocytes. Conclusions: Elastin/elastin fibers may control the functions of mammalian melanocytes in normal and abnormal skin.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127177599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. Haddad, Mariana Righetto de Reacute Lai, M. Barbosa, Andreacute Luiacutes Moura Balbino
Introduction: Sjogren-Larsson syndrome is a rare autosomal neurocutaneous disease, dermatologically manifested by congenital ichthyosis, associated with para/tetraplegia and developmental delay. Case Presentation: We present the case of two triplet patients, a girl, and a boy, 3 months old, admitted to the intensive care unit (ICU) due to respiratory distress, swallowing, and spasticity. The dermatological evaluation was requested due to the presence of generalized cutaneous xerosis, predominantly facial, in the girl and mild xerosis on the soles and face in the boy. The set of clinical signs and symptoms, together with the histopathological examination that revealed findings of ichthyosis, corroborated the diagnosis of this syndrome. Conclusions: The importance of describing this case is mainly due to the rarity of the presentation, especially in the case of triplets in which two of the brothers have the syndrome and one does not, as well as an alert to physicians for the correct diagnosis and multidisciplinary and dermatological follow-up.
{"title":"Sjogren Larsson Syndrome in Twins: Case Report","authors":"G. Haddad, Mariana Righetto de Reacute Lai, M. Barbosa, Andreacute Luiacutes Moura Balbino","doi":"10.5812/jssc-135792","DOIUrl":"https://doi.org/10.5812/jssc-135792","url":null,"abstract":"Introduction: Sjogren-Larsson syndrome is a rare autosomal neurocutaneous disease, dermatologically manifested by congenital ichthyosis, associated with para/tetraplegia and developmental delay. Case Presentation: We present the case of two triplet patients, a girl, and a boy, 3 months old, admitted to the intensive care unit (ICU) due to respiratory distress, swallowing, and spasticity. The dermatological evaluation was requested due to the presence of generalized cutaneous xerosis, predominantly facial, in the girl and mild xerosis on the soles and face in the boy. The set of clinical signs and symptoms, together with the histopathological examination that revealed findings of ichthyosis, corroborated the diagnosis of this syndrome. Conclusions: The importance of describing this case is mainly due to the rarity of the presentation, especially in the case of triplets in which two of the brothers have the syndrome and one does not, as well as an alert to physicians for the correct diagnosis and multidisciplinary and dermatological follow-up.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129592570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In this cross-sectional study, we investigated three diabetic foot ulcer (DFU) patients. DFU is a serious diabetes complication affecting general health and social life. Autologous regenerative therapies, such as autologous activated platelet-rich plasma (aaPRP), have been proposed for DFU management. However, precise instruments are required to measure the wound size to evaluate wound closure after treatment. Objectives: This study aimed to evaluate the DFU healing process treated by aaPRP through digital image analysis using ImageJ software (National Institute of Health, USA). Methods: The DFU patients were administered aaPRP and followed up on days 7 and 14. The healing process was analyzed through ImageJ software. Paired t-test was used to assess the wound healing process. Results: The results showed that ImageJ was useful for wound area measurement. Granulation and sloughy tissue development can be evaluated and calculated as a part of wound healing progress. Conclusions: We conclude that ImageJ facilitates DFU analysis not only about the size but also on the healing time process through visualization of granulation and sloughy tissue formation, which can represent the healing progress.
{"title":"Digital Image Analysis of Diabetic Foot Ulcer Areas Using ImageJ Software (National Institute of Health, USA) in Patients Treated with Autologous Activated Platelet-rich Plasma Injection","authors":"Dewi Fibrini, I. E. Lister, I. Rosadi","doi":"10.5812/jssc-135962","DOIUrl":"https://doi.org/10.5812/jssc-135962","url":null,"abstract":"Background: In this cross-sectional study, we investigated three diabetic foot ulcer (DFU) patients. DFU is a serious diabetes complication affecting general health and social life. Autologous regenerative therapies, such as autologous activated platelet-rich plasma (aaPRP), have been proposed for DFU management. However, precise instruments are required to measure the wound size to evaluate wound closure after treatment. Objectives: This study aimed to evaluate the DFU healing process treated by aaPRP through digital image analysis using ImageJ software (National Institute of Health, USA). Methods: The DFU patients were administered aaPRP and followed up on days 7 and 14. The healing process was analyzed through ImageJ software. Paired t-test was used to assess the wound healing process. Results: The results showed that ImageJ was useful for wound area measurement. Granulation and sloughy tissue development can be evaluated and calculated as a part of wound healing progress. Conclusions: We conclude that ImageJ facilitates DFU analysis not only about the size but also on the healing time process through visualization of granulation and sloughy tissue formation, which can represent the healing progress.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126534259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Seborrheic melanosis is one of the causes of facial hyperpigmentation presenting in the sebaceous areas of the face. It is most commonly seen in Fitzpatrick skin types 4 - 6. Seborrheic melanosis can cause cosmetic concerns for the patients, leading them to seek bleaching methods that could also be hazardous for them. Case Presentation: A 19-year-old male patient presented with dark brown spots on both sides of his nasolabial folds. According to the skin examination, there were nummular oval macules with hyperpigmentation and mild desquamation at the junction of the nasolabial fold and the supralabial area bilaterally. The patient applied an over-the-counter cream that contained hydroquinone to the hyperpigmented areas for bleaching for one month before he consulted our dermatology department. The pigmentation was homogeneous, brown-black, and showed no contrast under Wood’s light examination. Additionally, there were hyperpigmented macules on a seborrheic basement at the alar-supralabial junction bilaterally. The anamnesis and clinical findings supported the diagnosis of seborrheic melanosis. Tacrolimus ointment 0.1% once per night and isoconazole nitrate cream once per day were prescribed as treatments for one month. A water-based moisturizer and sunscreen were also added to the treatment. Further, he used a facial peeling combination of alpha-hydroxy acid 10% and beta-hydroxy acid 2% two times per week. Hyperpigmentation was barely discernible on his face five months after the beginning of the therapy. Conclusions: Seborrheic melanosis must be distinguished from other types of facial melanoses in order to start appropriate treatment. To ensure the most effective treatment, a comprehensive evaluation of the patient’s medical history and a thorough physical examination are essential for an accurate diagnosis of seborrheic melanosis.
{"title":"Bilateral Symmetrical Oval Hyperpigmentation on the Face: A Case of Seborrheic Melanosis","authors":"Serap Maden","doi":"10.5812/jssc-135821","DOIUrl":"https://doi.org/10.5812/jssc-135821","url":null,"abstract":"Introduction: Seborrheic melanosis is one of the causes of facial hyperpigmentation presenting in the sebaceous areas of the face. It is most commonly seen in Fitzpatrick skin types 4 - 6. Seborrheic melanosis can cause cosmetic concerns for the patients, leading them to seek bleaching methods that could also be hazardous for them. Case Presentation: A 19-year-old male patient presented with dark brown spots on both sides of his nasolabial folds. According to the skin examination, there were nummular oval macules with hyperpigmentation and mild desquamation at the junction of the nasolabial fold and the supralabial area bilaterally. The patient applied an over-the-counter cream that contained hydroquinone to the hyperpigmented areas for bleaching for one month before he consulted our dermatology department. The pigmentation was homogeneous, brown-black, and showed no contrast under Wood’s light examination. Additionally, there were hyperpigmented macules on a seborrheic basement at the alar-supralabial junction bilaterally. The anamnesis and clinical findings supported the diagnosis of seborrheic melanosis. Tacrolimus ointment 0.1% once per night and isoconazole nitrate cream once per day were prescribed as treatments for one month. A water-based moisturizer and sunscreen were also added to the treatment. Further, he used a facial peeling combination of alpha-hydroxy acid 10% and beta-hydroxy acid 2% two times per week. Hyperpigmentation was barely discernible on his face five months after the beginning of the therapy. Conclusions: Seborrheic melanosis must be distinguished from other types of facial melanoses in order to start appropriate treatment. To ensure the most effective treatment, a comprehensive evaluation of the patient’s medical history and a thorough physical examination are essential for an accurate diagnosis of seborrheic melanosis.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128505877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Rosadi, Muhammadiyah Muhammadiyah, Thania Fathimah Az Zahra, N. Hariani
Context: Using stem cells in the medical field as a regenerative therapy to repair damaged tissue is popular nowadays. Honey contains antioxidant activity, minerals, sugars, and other ingredients supporting wound healing and mature tissue regeneration. However, using honey to induce stem cell proliferation still lacks studies. In this review, we would like to do a systematic review to confirm the effectiveness of honey bees towards stem cell proliferation in both in vitro and in vivo treatment. Objectives: This study used all previous studies that included honey bees and stem cells in both in vitro and in vivo treatments. The search was performed on July 30th – 31st, 2021, and obtained 21 articles, of which 16 were excluded and the rest were screened. One screened literature was out of the limit; thus, five articles matched the terms. Relevant studies were retrieved from PubMed and the Cochrane Library. Data Methods: According to in vitro studies, honey of Trigona spp. increases the proliferation rate of dental pulp stem cells (DPSCs). Honey is effective for wound healing and stem cell regeneration. Meanwhile, in vivo studies showed honey increases the regeneration of malnutrition ovary failure. Results: According to in vitro studies, honey of Trigona spp. increases the proliferation rate of DPSCs. Honey is effective for wound healing and stem cell regeneration. Meanwhile, in vivo studies showed honey increases the regeneration of malnutrition ovary failure Conclusions: In conclusion, honey positively affects stem cell proliferation and can be used to supplement stem cells.
{"title":"The Effectivity of Honey Bee Towards Mesenchymal Stem Cells Proliferation: A Systematic Review","authors":"I. Rosadi, Muhammadiyah Muhammadiyah, Thania Fathimah Az Zahra, N. Hariani","doi":"10.5812/jssc-118960","DOIUrl":"https://doi.org/10.5812/jssc-118960","url":null,"abstract":"Context: Using stem cells in the medical field as a regenerative therapy to repair damaged tissue is popular nowadays. Honey contains antioxidant activity, minerals, sugars, and other ingredients supporting wound healing and mature tissue regeneration. However, using honey to induce stem cell proliferation still lacks studies. In this review, we would like to do a systematic review to confirm the effectiveness of honey bees towards stem cell proliferation in both in vitro and in vivo treatment. Objectives: This study used all previous studies that included honey bees and stem cells in both in vitro and in vivo treatments. The search was performed on July 30th – 31st, 2021, and obtained 21 articles, of which 16 were excluded and the rest were screened. One screened literature was out of the limit; thus, five articles matched the terms. Relevant studies were retrieved from PubMed and the Cochrane Library. Data Methods: According to in vitro studies, honey of Trigona spp. increases the proliferation rate of dental pulp stem cells (DPSCs). Honey is effective for wound healing and stem cell regeneration. Meanwhile, in vivo studies showed honey increases the regeneration of malnutrition ovary failure. Results: According to in vitro studies, honey of Trigona spp. increases the proliferation rate of DPSCs. Honey is effective for wound healing and stem cell regeneration. Meanwhile, in vivo studies showed honey increases the regeneration of malnutrition ovary failure Conclusions: In conclusion, honey positively affects stem cell proliferation and can be used to supplement stem cells.","PeriodicalId":174870,"journal":{"name":"Journal of Skin and Stem Cell","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115111393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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