The wound is a physical injury that results in tears and damage to skin tissue. One type of wound is excision wound, excision wound is of the a wound that is caused by cutting tissue by sharp object scratches. The main goal in wound management is to achieve rapid healing with optimal function and good results. That can be achieved by preventing further infection and trauma with the availability of an environment that can optimize the healing of the wound. One plant that has the potential to heal wounds is the paper petal plant. The purpose of thes study is to find out the effectiveness of giving paper petal extract to the healing of excision wounds in male rats. The study conducted in the Laboratory Health Institute of the Deli Husada Deli Tua. The extracts formulated into ointment preparations with concentrations of 10%, 15%, and 20% then conducted evaluation of ointment preparations, namely organoleptic tests, homogeneity tests, ph tests, visicosity tests, hedonic tests and spread power tests. The results of organoleptic tests and irritant tests of paper petal ethanol extract ointment preparations, all concentrations were declared good while in the most preferred hedonic test was a concentration of 10%. From the results of the spread test is a concentration of 15% with a static test value on the 21st day which is 6.3000 where this value is equal to the value of povidone iodine, while in the pH test on the 21st day the concentration that sees the best statistic test value is 10% concentration with a value of 6.4467 which is close to the value of povidone iodine which is 7.3133. The results of the study is each treatment group experienced a decrease in the diameter of the cut wound. Of the 5 treatment groups, the best reduction in the diameter of the cut wound was the positive control group (povidone iodine) and the 20% concentration where the statistic test value on the 15th day was 0.0000 where this value was equal to the value of povidone iodine.
{"title":"UJI EFEKTIVITAS SALEP EKSTRAK ETANOL DAUN BUNGA KERTAS (BOUGAINVILLEA GLABRA) TERHADAP LUKA EKSISI PADA TIKUS JANTAN PEMBANDING POVIDONE IODINE SALEP","authors":"D. Simorangkir","doi":"10.36656/jpfh.v4i2.854","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.854","url":null,"abstract":"The wound is a physical injury that results in tears and damage to skin tissue. One type of wound is excision wound, excision wound is of the a wound that is caused by cutting tissue by sharp object scratches. The main goal in wound management is to achieve rapid healing with optimal function and good results. That can be achieved by preventing further infection and trauma with the availability of an environment that can optimize the healing of the wound. One plant that has the potential to heal wounds is the paper petal plant. The purpose of thes study is to find out the effectiveness of giving paper petal extract to the healing of excision wounds in male rats. The study conducted in the Laboratory Health Institute of the Deli Husada Deli Tua. The extracts formulated into ointment preparations with concentrations of 10%, 15%, and 20% then conducted evaluation of ointment preparations, namely organoleptic tests, homogeneity tests, ph tests, visicosity tests, hedonic tests and spread power tests. The results of organoleptic tests and irritant tests of paper petal ethanol extract ointment preparations, all concentrations were declared good while in the most preferred hedonic test was a concentration of 10%. From the results of the spread test is a concentration of 15% with a static test value on the 21st day which is 6.3000 where this value is equal to the value of povidone iodine, while in the pH test on the 21st day the concentration that sees the best statistic test value is 10% concentration with a value of 6.4467 which is close to the value of povidone iodine which is 7.3133. The results of the study is each treatment group experienced a decrease in the diameter of the cut wound. Of the 5 treatment groups, the best reduction in the diameter of the cut wound was the positive control group (povidone iodine) and the 20% concentration where the statistic test value on the 15th day was 0.0000 where this value was equal to the value of povidone iodine. \u0000 ","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82290640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manila sapodilla leaves contain phytochemical mixtures of alkaloids, flavonoids, saponins, tannins, terpenoids and glycosides which are known to have antibacterial movement of Staphylococcus aureus and Escherichia coli. The reason for this study was whether the planning of sapodilla leaf extricate salve can be utilized as an enemy of bacterial technique. This exploration was led utilizing a trial which plans to decide all side effects or impacts that emerge, because of specific medicines. Sawo Leaf Ethanol Extract was completed by submerging maceration utilizing 96% ethanol. Antibacterial action testing was done on Sawo leaf extricate with different centralizations of 5%, 10% and 20% and Chaladine cream as a positive control was completed utilizing the discdiffusion strategy. The consequences of the restraint zone movement of Staphylococcus aureus antibacterial lotio arrangements Chaladine sapodilla leaf remove 18 mm, Extract focus 5% 14.5 mm, Extract fixation 10% 20.3 mm, Extract focus 20% 15.46 mm, The aftereffects of the inhibitory zone action in the cream readiness antibacterial concentrate of sapodilla lotio leaf Escherichia coli lotio Chaladine 14 mm, Extract focus 5% 14.16 mm, Extract fixation 10% 20.3 mm, Extract fixation 20% 16.06 mm > 0.05, this demonstrates that the information are typically dispersed, homogeneity trial of 2 gatherings of microscopic organisms and shows a meaning of p > 0.05, showing that the information utilized came from homogeneous information. This demonstrates that Lotio ethanol concentrate of sapodilla leaves has antibacterial movement.
{"title":"FORMULASI DAN UJI EKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN SAWAO TERHADAP BAKTERI Stapylococcuc aureus dan Escherchia coli","authors":"Pintata Sembiring","doi":"10.36656/jpfh.v4i2.853","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.853","url":null,"abstract":"Manila sapodilla leaves contain phytochemical mixtures of alkaloids, flavonoids, saponins, tannins, terpenoids and glycosides which are known to have antibacterial movement of Staphylococcus aureus and Escherichia coli. The reason for this study was whether the planning of sapodilla leaf extricate salve can be utilized as an enemy of bacterial technique. This exploration was led utilizing a trial which plans to decide all side effects or impacts that emerge, because of specific medicines. Sawo Leaf Ethanol Extract was completed by submerging maceration utilizing 96% ethanol. Antibacterial action testing was done on Sawo leaf extricate with different centralizations of 5%, 10% and 20% and Chaladine cream as a positive control was completed utilizing the discdiffusion strategy. The consequences of the restraint zone movement of Staphylococcus aureus antibacterial lotio arrangements Chaladine sapodilla leaf remove 18 mm, Extract focus 5% 14.5 mm, Extract fixation 10% 20.3 mm, Extract focus 20% 15.46 mm, The aftereffects of the inhibitory zone action in the cream readiness antibacterial concentrate of sapodilla lotio leaf Escherichia coli lotio Chaladine 14 mm, Extract focus 5% 14.16 mm, Extract fixation 10% 20.3 mm, Extract fixation 20% 16.06 mm > 0.05, this demonstrates that the information are typically dispersed, homogeneity trial of 2 gatherings of microscopic organisms and shows a meaning of p > 0.05, showing that the information utilized came from homogeneous information. This demonstrates that Lotio ethanol concentrate of sapodilla leaves has antibacterial movement.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84013047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes is a disease in which the blood sugar level rises above the normal level. When blood sugar levels are regulated by the hormone insulin produced by the pancreas. The fig fruit (Ficus carica Linn) is a plant that is thought to be used as an herbal remedy in the management of diabetes. Contains flavonoids which are thought to have potential as antidiabetic. Flavonoid mechanism in reducing blood glucose levels is to reduce glucose absorption and increase insulin secretion. Flavonoids are phenol compounds that have several pharmacological activities. Objective knowing antidiabetic activity of fig extract (Ficus carica Linn) against mice induced by alloxan. The process used is a 70% ethanol solvent immersion process. This study method is designed before and after the control group. Fifteen rats were divided into 5 treatment groups. 1 (negative control) received the CMC Na 1% group, 2 (positive control) received glibenclamide 0.09 mg / kgBB, 3, 4 and 5 received 9 mg / kgBB, 18 mg / kgBB, and 36 mg / kg. The fig extract was administered at a dose of kgBB. Previously, rats were given alloxan 125 mg / kg BB intraperitoneally for 3 days and mice with a blood glucose level of ± 200 mg / dL were used in this study. The results of this study showed that glibenclamide 0,09 mg/kgBB and fig extract dose 36 mg/kgBB could reduce the best glucose levels for seven days. Conclusion the best glibenclamid as antidiabetic in male white rats induced by alloxan and fig extract at a dose of 36 mg/kgBB 1,5% concentration is good as antidiabetic mellitus in male white mice induced by alloxan.
{"title":"UJI AKTIVITAS EKSTRAK BUAH ARA (Ficus carica Linn) TERHADAP TIKUS YANG DI INDUKSI ALOKSAN","authors":"Atika Suri","doi":"10.36656/jpfh.v4i2.865","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.865","url":null,"abstract":"Diabetes is a disease in which the blood sugar level rises above the normal level. When blood sugar levels are regulated by the hormone insulin produced by the pancreas. The fig fruit (Ficus carica Linn) is a plant that is thought to be used as an herbal remedy in the management of diabetes. Contains flavonoids which are thought to have potential as antidiabetic. Flavonoid mechanism in reducing blood glucose levels is to reduce glucose absorption and increase insulin secretion. Flavonoids are phenol compounds that have several pharmacological activities. Objective knowing antidiabetic activity of fig extract (Ficus carica Linn) against mice induced by alloxan. The process used is a 70% ethanol solvent immersion process. This study method is designed before and after the control group. Fifteen rats were divided into 5 treatment groups. 1 (negative control) received the CMC Na 1% group, 2 (positive control) received glibenclamide 0.09 mg / kgBB, 3, 4 and 5 received 9 mg / kgBB, 18 mg / kgBB, and 36 mg / kg. The fig extract was administered at a dose of kgBB. Previously, rats were given alloxan 125 mg / kg BB intraperitoneally for 3 days and mice with a blood glucose level of ± 200 mg / dL were used in this study. The results of this study showed that glibenclamide 0,09 mg/kgBB and fig extract dose 36 mg/kgBB could reduce the best glucose levels for seven days. Conclusion the best glibenclamid as antidiabetic in male white rats induced by alloxan and fig extract at a dose of 36 mg/kgBB 1,5% concentration is good as antidiabetic mellitus in male white mice induced by alloxan.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"71 6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87733427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nilam leaves contain flavonoids. flavonoids that have activity that can accelerate hair growth and prevent hair loss. The purpose of the study was to make a hair tonic preparation containing patchouli leaf extract and to determine the concentration of the best formula to treat hair loss. Hair tonic is made with nilam leaf extract at concentrations of 5%, 10%, 15%. The ingredients for making Hair Tonic include propylene glycol, propyl paraben, methyl paraben, menthol, sodium metabisulfite, 96% ethanol, Ol. Rosae, Aquades. The method of the study an experimental method with extraction by maceration for 5 days and remaceration for 2 days using 96% ethanol as solvent. Evaluation of Hair Tonic preparations includes homogeneity, pH, organoleptic, viscosity, irritation, preference, and hair growth effectiveness test. The effectiveness test on hair growth in rabbits was carried out on 5 rabbits with 5 treatment groups, namely, positive control group Hair Tonic nature, negative control group, 5% concentration group, 10% concentration group, and 15% concentration group. The analysis of the data on growth testing using One Way Anova. Hair growth data on day 12 were positive control 0.95 mm, negative control 0.03 mm, formula 1 (5%) 0.08 mm, formula 2 (10%) 0.13 mm, formula 3 (15%) 0.83mm. The best formula to treat hair loss is hair tonic with a concentration of 15% nilam leaf ethanol extract. It can be concluded that the greater the concentration of nilam leaf extract given to each treatment, the faster the hair growth.
{"title":"The FORMULATION AND EVALUATION O FORMULATION AND EVALUATION OF THE PREPARATION OF HAIR TONIC Ethanol Extract of Patchouli Leaves (Pogostemon cablin Benth.) TO OVERCOME HAIR LOSS","authors":"B. Barus, Linta Meliala","doi":"10.36656/jpfh.v4i2.860","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.860","url":null,"abstract":"Nilam leaves contain flavonoids. flavonoids that have activity that can accelerate hair growth and prevent hair loss. The purpose of the study was to make a hair tonic preparation containing patchouli leaf extract and to determine the concentration of the best formula to treat hair loss. Hair tonic is made with nilam leaf extract at concentrations of 5%, 10%, 15%. The ingredients for making Hair Tonic include propylene glycol, propyl paraben, methyl paraben, menthol, sodium metabisulfite, 96% ethanol, Ol. Rosae, Aquades. The method of the study an experimental method with extraction by maceration for 5 days and remaceration for 2 days using 96% ethanol as solvent. Evaluation of Hair Tonic preparations includes homogeneity, pH, organoleptic, viscosity, irritation, preference, and hair growth effectiveness test. The effectiveness test on hair growth in rabbits was carried out on 5 rabbits with 5 treatment groups, namely, positive control group Hair Tonic nature, negative control group, 5% concentration group, 10% concentration group, and 15% concentration group. The analysis of the data on growth testing using One Way Anova. Hair growth data on day 12 were positive control 0.95 mm, negative control 0.03 mm, formula 1 (5%) 0.08 mm, formula 2 (10%) 0.13 mm, formula 3 (15%) 0.83mm. The best formula to treat hair loss is hair tonic with a concentration of 15% nilam leaf ethanol extract. It can be concluded that the greater the concentration of nilam leaf extract given to each treatment, the faster the hair growth.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"84 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79115709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes mellitus is a chronic metabolic disease characterized by an increase in blood glucose levels which can be treated with traditional treatments derived from plants. One of the example is a plant that can reduce blood glucose levels are bitter melon and rosella which contain flavonoids to reduce blood glucose by increasing cell sensitivity to insulin and stimulating insulin release in pancreatic β cells. The objective of the research is to determine the effect of the combination of bitter melon extract and rosella petal extract in reducing blood glucose levels compared to glibenclamide. The method of the research is an experimental study used 21 rats induced by alloxan and divided into 7 groups. Extraction using maceration method with 80% ethanol. From the results of the study, each treatment group experienced a decrease in blood glucose levels. From the 7 treatment groups, the best reduction in blood glucose levels were the third combination group. Among the three combination groups, the combination dose of 225 mg/kgBB of bitter melon and 195 mg/kgBB of rosella flower petals was the best compared to glibenclamide in reducing blood glucose levels. The conclusion of the research is combination of bitter melon extract and rosella flower petals have an effect that are more effective in reducing blood glucose levels compared to glibenclamide and their single extract.
{"title":"Uji Efektivitas Antidiabetes Kombinasi Ekstrak Buah Pare (Momordica charantia L.) Dan Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Pada Tikus Jantan Putih Sebagai Hewan Percobaan","authors":"Anggun Syafitri","doi":"10.36656/jpfh.v4i2.847","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.847","url":null,"abstract":"Diabetes mellitus is a chronic metabolic disease characterized by an increase in blood glucose levels which can be treated with traditional treatments derived from plants. One of the example is a plant that can reduce blood glucose levels are bitter melon and rosella which contain flavonoids to reduce blood glucose by increasing cell sensitivity to insulin and stimulating insulin release in pancreatic β cells. The objective of the research is to determine the effect of the combination of bitter melon extract and rosella petal extract in reducing blood glucose levels compared to glibenclamide. The method of the research is an experimental study used 21 rats induced by alloxan and divided into 7 groups. Extraction using maceration method with 80% ethanol. From the results of the study, each treatment group experienced a decrease in blood glucose levels. From the 7 treatment groups, the best reduction in blood glucose levels were the third combination group. Among the three combination groups, the combination dose of 225 mg/kgBB of bitter melon and 195 mg/kgBB of rosella flower petals was the best compared to glibenclamide in reducing blood glucose levels. The conclusion of the research is combination of bitter melon extract and rosella flower petals have an effect that are more effective in reducing blood glucose levels compared to glibenclamide and their single extract.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77870739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tobacco leaves (Nicotiana tabacum L.) have secondary metabolites namely alkaloids as antibacterial, flavonoids and steroids / terpenoids as antimicrobials and adstringers which play a role in wound shrinkage, efficacious saponins stimulate collagen formation. This study aims to determine the effectiveness of tobacco leaf gel ethanol extract in the healing of burns. Tobacco leaf extract was prepared using a 96% ethanol immersion process. This study of tobacco leaf extract is prescribed in the form of gels at 5%, 10%, and 15% concentrations. There were five groups in this study. The first group (positive control), the second group (negative control), and the third group are tobacco leaf ethanol extract gels 5%, 10%, and 15%. In this study, 15 rats with burns on the backs of mice coated with the test preparation will be measured and photographed once daily. This is done until the wound is 0 cm in diameter or covered with new tissue. The data results of the mean wound healing rate data were statistically tested using the SPSS program. We analyzed the data using Oneway, ANOVA, TukeysB, and LSD to see the actual differences between the processes. The data results of the analysis on day 16 showed that the 15% tobacco leaf ethanol extract had a wound healing effect that was not significantly different from the positive control (Bioplasenton) (p> 0.05). cure burns that are comparable to comparable drugs (Bioplasenton). The conclusion of this study is that the most effective gel concentration is 15% with the day of recovery on the 16th day.
{"title":"PENGUJIAN EFEKTIVITAS PENYEMBUHAN LUKA BAKAR GEL EKSTRAK ETANOL DAUN TEMBAKAU (Nicotiana tabacum L.) PADA TIKUS","authors":"Mona Hutagalung","doi":"10.36656/jpfh.v4i2.868","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.868","url":null,"abstract":"Tobacco leaves (Nicotiana tabacum L.) have secondary metabolites namely alkaloids as antibacterial, flavonoids and steroids / terpenoids as antimicrobials and adstringers which play a role in wound shrinkage, efficacious saponins stimulate collagen formation. This study aims to determine the effectiveness of tobacco leaf gel ethanol extract in the healing of burns. Tobacco leaf extract was prepared using a 96% ethanol immersion process. This study of tobacco leaf extract is prescribed in the form of gels at 5%, 10%, and 15% concentrations. There were five groups in this study. The first group (positive control), the second group (negative control), and the third group are tobacco leaf ethanol extract gels 5%, 10%, and 15%. In this study, 15 rats with burns on the backs of mice coated with the test preparation will be measured and photographed once daily. This is done until the wound is 0 cm in diameter or covered with new tissue. The data results of the mean wound healing rate data were statistically tested using the SPSS program. We analyzed the data using Oneway, ANOVA, TukeysB, and LSD to see the actual differences between the processes. The data results of the analysis on day 16 showed that the 15% tobacco leaf ethanol extract had a wound healing effect that was not significantly different from the positive control (Bioplasenton) (p> 0.05). cure burns that are comparable to comparable drugs (Bioplasenton). The conclusion of this study is that the most effective gel concentration is 15% with the day of recovery on the 16th day.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83456053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The titanus plant (Leea aequata L.) is a plant that used as traditional medicine. The stems and roots are used as astringent, anthelmintic, indigestion, jaundice, chronic fever and malaria. The leaves and twigs are used as an antiseptic and to treat wounds. Steroids are secondary metabolites that have a compound structure that quite diverse. Steroids have a pharmacological effect on lowering cholesterol and anticarcinogenic. The objective of the research to determine the steroid levels in titanus leaf extract (Leea aequata L.). The analytical method used is qualitative with reagents Lieberman-Bouchard and quantitative uv-vis spectrophotometry with wavelength of 423 nm. The results of the qualitative analysis of the positive samples contained steroid compounds. The Results quantitative content of ethanol extract of titanus leaf 30.8889 mg/g, and quantitative results ethyl acetate extract content of titanus leaves 72.2649 mg/g. Validity test results obtained linearity test r=0.9994, RSD of ethanol extract 0,2852% and ethyl acetate extract 8,1120%, recovery of 101% ethanol extract and 103.667% ethyl acetate extract, LOD 2.2078 and LOQ 7,3593. SPSS analysis results p=0.000 (p<0.05). Based on the results of the research that has been done, it can be concluded that uv-vis spectrophotometry can be used to determine total steroid content of titanus leaf extract (Leea aequata L.).
{"title":"PENETAPAN KADAR STEROID PADA EKSTRAK DAUN TITANUS (Leea aequata L.) SECARA SPEKTROFOTOMETRI UV-VIS","authors":"Dian Ika Perbina, Jhan Saberlan Purba","doi":"10.36656/jpfh.v4i1.768","DOIUrl":"https://doi.org/10.36656/jpfh.v4i1.768","url":null,"abstract":"The titanus plant (Leea aequata L.) is a plant that used as traditional medicine. The stems and roots are used as astringent, anthelmintic, indigestion, jaundice, chronic fever and malaria. The leaves and twigs are used as an antiseptic and to treat wounds. Steroids are secondary metabolites that have a compound structure that quite diverse. Steroids have a pharmacological effect on lowering cholesterol and anticarcinogenic. The objective of the research to determine the steroid levels in titanus leaf extract (Leea aequata L.). The analytical method used is qualitative with reagents Lieberman-Bouchard and quantitative uv-vis spectrophotometry with wavelength of 423 nm. The results of the qualitative analysis of the positive samples contained steroid compounds. The Results quantitative content of ethanol extract of titanus leaf 30.8889 mg/g, and quantitative results ethyl acetate extract content of titanus leaves 72.2649 mg/g. Validity test results obtained linearity test r=0.9994, RSD of ethanol extract 0,2852% and ethyl acetate extract 8,1120%, recovery of 101% ethanol extract and 103.667% ethyl acetate extract, LOD 2.2078 and LOQ 7,3593. SPSS analysis results p=0.000 (p<0.05). Based on the results of the research that has been done, it can be concluded that uv-vis spectrophotometry can be used to determine total steroid content of titanus leaf extract (Leea aequata L.).","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88897455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The gardenia jasminoides ellis contain flavonoids which have antioxidant and the antibacterial effects. Traditional use requires a long preparation, so it is necessary to formulate preparations that are more practical and durable in storage. The gel preparation was chosen in the formulation because it dries easily, forms a film that is easy to wash off and provides a cooling feeling on the skin. The gel component affects of the stability of the gel. The stability tests need to be carried out to ensure the quality, safety and efficacy of the gel meets the expected specifications and is stable during storage. The aims of the study to determine the difference in of the physical stability of the gel preparation of Gardenia jaminoides ellis and acnes spot gel on the market and determine the concentration of gardenia jasminoides ellis extract which has the best physical stability. Methods: The research of the method is experimental laboratory. Simplicia was extracted using 96% ethanol as solvent. The extract was formulated in gel dosage form with a concentration of 0.5% (FI), 1% (FII) and 1.5% (FIII). The results of study: The physical stability of the preparation tested by organoleptic, homogeneity, pH test, adhesion test, viscosity test, hedonic test and gel stability test which were compared with gels on the market. The results of the physical stability of the preparation observed at room temperature, the pH of the market gel was more acidic than the gardenia jasminoides ellis extract. The viscosity of formula 3 is higher in viscosity. In the stability test, it was seen that from the three formulas and gels on the market there was no change in shape, color and odor.
{"title":"FORMULASI DAN PERBANDINGAN UJI STABILITAS FISIK SEDIAAN GEL EKSTRAK DAUN KACAPIRING (GARDENIA JASMINOIDES ELLIS) DAN ACNES SPOT GEL DIPASARAN","authors":"Sofia Eliasari","doi":"10.36656/jpfh.v4i1.754","DOIUrl":"https://doi.org/10.36656/jpfh.v4i1.754","url":null,"abstract":"Background: The gardenia jasminoides ellis contain flavonoids which have antioxidant and the antibacterial effects. Traditional use requires a long preparation, so it is necessary to formulate preparations that are more practical and durable in storage. The gel preparation was chosen in the formulation because it dries easily, forms a film that is easy to wash off and provides a cooling feeling on the skin. The gel component affects of the stability of the gel. The stability tests need to be carried out to ensure the quality, safety and efficacy of the gel meets the expected specifications and is stable during storage. The aims of the study to determine the difference in of the physical stability of the gel preparation of Gardenia jaminoides ellis and acnes spot gel on the market and determine the concentration of gardenia jasminoides ellis extract which has the best physical stability. \u0000Methods: The research of the method is experimental laboratory. Simplicia was extracted using 96% ethanol as solvent. The extract was formulated in gel dosage form with a concentration of 0.5% (FI), 1% (FII) and 1.5% (FIII). \u0000The results of study: The physical stability of the preparation tested by organoleptic, homogeneity, pH test, adhesion test, viscosity test, hedonic test and gel stability test which were compared with gels on the market. The results of the physical stability of the preparation observed at room temperature, the pH of the market gel was more acidic than the gardenia jasminoides ellis extract. The viscosity of formula 3 is higher in viscosity. In the stability test, it was seen that from the three formulas and gels on the market there was no change in shape, color and odor.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"42 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91469673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gelugur leaf (Garcinia atroviridis Griff ex T. Anderson) is a kind of nadir is believed to origanate from the wild forest of Peninsular Malaysia. Gelugur leaves have antidiarrheal compounds in the shapes of tannins and flavonoids to reduce diarrhea. The purpose of this study was to find out the antidiarrheal activity of the ethanolic extract of gelugur leaf in white male rats. The antidiarrheal effect was tested on 15 white male rats with 5 treatment groups, namely, a negative control group of 1% CMC Na, a positive control group of loperamidee hcl, and a treatment group of ethanol extract of gelugur leaves at a dose of 150 miligrams/kgBW, a dose of 300 miligrams/kgBW, and 600 miligrams/kg body weight. Each group was given oral treatment and observations were made on the onset of diarrhea, frequency of diarrhea, and stool consistency. Tests were carried out using an experimental method. The ethanol extract of gelugur leaves was made by maceration method using 96% ethanol. The results of the study on the onset of diarrhea were EEDG 600 miligrams/kgBB (60 minutes), a good decrease in diarrhea frequency was indicated by EEDG 600 miligrams/kgBB (4 times), a good decrease in stool weight was shown by EEDG 600 miligrams/ kgBB (0,7757 grams), good consistency was also shown in the EEDG 600 miligrams/kgBB (soft stools. The data were statistically analyzed using One Way Anova. The results of data analysis from the three EEDG groups affected the decrease in diarrhea because the sig value <0.05 Based on One Way Anova analysis, the five most effective treatments were loperamidee, 600 miligrams/kgBB, EEDG at 300 miligrams/kgBB, EEDG at 150 miligrams/kgBB, and CMC Na 1%. The conclusion in this study is that EEDG 600 miligrams/kgBB has antidiarrheal activity induced by oleum recini when compared with EEDG concentrations of 150 miligrams/kgBB and 300 miligrams/kgBB.
Gelugur leaf (Garcinia atroviridis Griff ex T. Anderson)是一种被认为起源于马来西亚半岛野生森林的植物。Gelugur叶子有止泻化合物的形状的单宁和类黄酮，以减少腹泻。本研究的目的是研究胶瓜叶乙醇提取物对白雄性大鼠的止泻作用。以15只雄性白种大鼠为实验对象，设1% CMC Na阴性对照组、盐酸洛哌丁胺阳性对照组、胶瓜叶乙醇提取物150 mg /kgBW、300 mg /kgBW、600 mg /kg体重处理组5个处理组，对其止泻作用进行了研究。各组均给予口服治疗，观察腹泻发病情况、腹泻次数、大便粘稠度。用实验方法进行了试验。采用96%乙醇浸渍法制备胶瓜叶乙醇提取物。研究结果显示，腹泻起病剂量为EEDG 600毫克/千克bb(60分钟)，腹泻频率下降较好，EEDG 600毫克/千克bb(4次)，大便重量下降较好(0.7757克)，一致性较好(软便)。数据采用单因素方差分析(One Way Anova)进行统计分析。经单因素方差分析(One - Way Anova analysis)，结果显示洛哌丁胺、600 mg /kgBB、300 mg /kgBB、150 mg /kgBB、CMC Na 1%是5种最有效的治疗方案。本研究的结论是600 mg /kgBB的EEDG与150 mg /kgBB和300 mg /kgBB的EEDG相比，具有异胃素诱导的止泻活性。
{"title":"UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GELUGUR (Garcinia atroviridis Griff ex. T Anderson)TERHADAP TIKUS JANTAN PUTIH (Rattus norvegicus) DENGAN LOPERAMIDE SEBAGAI PEMBANDING","authors":"Pintata Sembiring","doi":"10.36656/jpfh.v4i1.761","DOIUrl":"https://doi.org/10.36656/jpfh.v4i1.761","url":null,"abstract":"Gelugur leaf (Garcinia atroviridis Griff ex T. Anderson) is a kind of nadir is believed to origanate from the wild forest of Peninsular Malaysia. Gelugur leaves have antidiarrheal compounds in the shapes of tannins and flavonoids to reduce diarrhea. The purpose of this study was to find out the antidiarrheal activity of the ethanolic extract of gelugur leaf in white male rats. The antidiarrheal effect was tested on 15 white male rats with 5 treatment groups, namely, a negative control group of 1% CMC Na, a positive control group of loperamidee hcl, and a treatment group of ethanol extract of gelugur leaves at a dose of 150 miligrams/kgBW, a dose of 300 miligrams/kgBW, and 600 miligrams/kg body weight. Each group was given oral treatment and observations were made on the onset of diarrhea, frequency of diarrhea, and stool consistency. Tests were carried out using an experimental method. The ethanol extract of gelugur leaves was made by maceration method using 96% ethanol. The results of the study on the onset of diarrhea were EEDG 600 miligrams/kgBB (60 minutes), a good decrease in diarrhea frequency was indicated by EEDG 600 miligrams/kgBB (4 times), a good decrease in stool weight was shown by EEDG 600 miligrams/ kgBB (0,7757 grams), good consistency was also shown in the EEDG 600 miligrams/kgBB (soft stools. The data were statistically analyzed using One Way Anova. The results of data analysis from the three EEDG groups affected the decrease in diarrhea because the sig value <0.05 Based on One Way Anova analysis, the five most effective treatments were loperamidee, 600 miligrams/kgBB, EEDG at 300 miligrams/kgBB, EEDG at 150 miligrams/kgBB, and CMC Na 1%. The conclusion in this study is that EEDG 600 miligrams/kgBB has antidiarrheal activity induced by oleum recini when compared with EEDG concentrations of 150 miligrams/kgBB and 300 miligrams/kgBB.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"358 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78103992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This modern society does not know much about the benefits of medicinal plants for health, because people are more familiar with drugs from chemicals. Many plants have imunostimulant activities, one of them is bagun-bangun (Coleus amboinicus L.) which is widely used as a stimulant, carminative, antispasmodic, diuretic, antioxidant and anti-rheumatic.The purpos of thiss research wass to determin the effective of etanol extract of bagun-bangun seeds (EEDB) on imunostimuensitivity lan hypereduction in male white rats compared with stimuno. Methods: The method used experimental. The sample of in this research was bangun-bangun seeds which were take purposivelyy without comparring samples from the other regiions, thenit is extracted by maceration using 80% ethanol and made in the form of thick extract. The results of the study: Imunostimulan efectivity effects were tested on 25 male rats with 5 treatment groups namely, negative group (CMC Na 1%), positive group (stimuno), EEDB group 100mg/kgBW, EEDB group 200mg/kgBW, and EEDB group 300mg/kgBB. Data analysis use the one way ANOVA method.The resultss of the studyy show thatt the most effectiv treatmentt was simvastatin and among the efective dosage ofEECS was a dose of 300mg/KgBW. The resultss of data analysis from the tthree EEDB groups had an effect on cholesterol reducttion due to the sig value <0.05. Based on anovva one way analysis of the five most effective treatmentss was stimuno then EEDB 300mg/kgBW, EEDB 200mg/kgBW, EEDB 100mg/kgBW and CMC Na 1%.EEDB has an effect on imunostimulan reduction but does not give better results than stimuno.
{"title":"EFEKTIVITAS IMUNOSTIMULAN DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus amboinicus L.) PADA TIKUS JANTAN DENGAN STIMUNO SEBAGAI PEMBANDING TAHUN 2021","authors":"Anggun Syafitri, Linta Meliala","doi":"10.36656/jpfh.v4i1.757","DOIUrl":"https://doi.org/10.36656/jpfh.v4i1.757","url":null,"abstract":"Background: This modern society does not know much about the benefits of medicinal plants for health, because people are more familiar with drugs from chemicals. Many plants have imunostimulant activities, one of them is bagun-bangun (Coleus amboinicus L.) which is widely used as a stimulant, carminative, antispasmodic, diuretic, antioxidant and anti-rheumatic.The purpos of thiss research wass to determin the effective of etanol extract of bagun-bangun seeds (EEDB) on imunostimuensitivity lan hypereduction in male white rats compared with stimuno. \u0000Methods: The method used experimental. The sample of in this research was bangun-bangun seeds which were take purposivelyy without comparring samples from the other regiions, thenit is extracted by maceration using 80% ethanol and made in the form of thick extract. \u0000The results of the study: Imunostimulan efectivity effects were tested on 25 male rats with 5 treatment groups namely, negative group (CMC Na 1%), positive group (stimuno), EEDB group 100mg/kgBW, EEDB group 200mg/kgBW, and EEDB group 300mg/kgBB. Data analysis use the one way ANOVA method.The resultss of the studyy show thatt the most effectiv treatmentt was simvastatin and among the efective dosage ofEECS was a dose of 300mg/KgBW. The resultss of data analysis from the tthree EEDB groups had an effect on cholesterol reducttion due to the sig value <0.05. Based on anovva one way analysis of the five most effective treatmentss was stimuno then EEDB 300mg/kgBW, EEDB 200mg/kgBW, EEDB 100mg/kgBW and CMC Na 1%.EEDB has an effect on imunostimulan reduction but does not give better results than stimuno.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79022791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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