Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.
{"title":"ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO","authors":"Azka Khoirunnisa, A. Jamil, Artabah Muchlisin","doi":"10.36656/jpfh.v6i2.1686","DOIUrl":"https://doi.org/10.36656/jpfh.v6i2.1686","url":null,"abstract":"Cancer remains a global health challenge, prompting extensive research efforts worldwide. Lung cancer, the second most diagnosed cancer, presents a particularly grim survival rate. In Indonesia, cancer incidence ranks significantly, with millions affected and hundreds of thousands succumbing to the disease annually. Traditional medicine persists as a preferred option among many, perceived as safer and more affordable. Abrus precatorius L., an ancient medicinal plant, holds promise in this regard, with a rich history of use and a diverse range of pharmacological activities, including anti-cancer properties. Employing in silico modeling and network pharmacology, this study explores the interaction between Abrus precatorius L. compounds and various proteins associated with cancer. Through bioinformatics tools and databases, 27 bioactive compounds are identified and their physicochemical properties assessed, ensuring adherence to pharmacological guidelines. The study predicts potential protein targets for Abrus precatorius L. compounds, revealing interactions with 453 proteins, including those implicated in cancer pathways. Further analysis using StringDB and DISEASES database establishes protein-protein interaction networks, highlighting key proteins like EGFR and TERT, pivotal in multiple cancer types. The study validates the compounds' adherence to Lipinski's Rule of Five, indicating their potential for pharmacological activity and oral absorption. False Discovery Rate (FDR) analysis confirms significant associations between Abrus precatorius L. compounds and various cancers, further underscoring their therapeutic potential. In conclusion, Abrus precatorius L. compounds, particularly targeting EGFR and TERT proteins, emerge as promising candidates for cancer treatment. Their diverse pharmacological activities and interactions with key cancer-related proteins pave the way for further exploration and development of these compounds as alternative medicinal agents. In vitro and in vivo studies are warranted to validate their efficacy, particularly in addressing the complexities of different cancer types. Ultimately, this research offers valuable insights into leveraging natural compounds for combating cancer, addressing a critical need in global healthcare.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"290 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
One of the vegetation that may be used each as meals and medication is the Moringa plant (Moringa oleifera L.). Empirically, Moringa leaves have many advantages and had been proven to be powerful in treating numerous diseases, consisting of diabetes, hepatitis, heart ailment and excessive cholesterol. The chemical parts contained on this plant are terpenoids, tannins, steroids, polyphenols, and alkaloids. This look at aims to pick out medicinal uncooked substances the use of the meals dehydrator drying method whilst on the equal time making sure the drug raw materials, so that the standardization can be accounted for for its quality. Standardization is done by setting specific and non-specific parameters. This study uses descriptive qualitative and quantitative analysis methods. The sample of this research was taken from Luwung village, Sidoarjo regency. The results of standardization for specific parameters showed the determination of the flavonoid content of 16,08±3,62 mgQE/g, the TLC test showed stains in the form of yellow-green fluorescence under UV light at 366 nm, the water-soluble extract test yielded 7.8%, and the water-soluble extract test yielded 7.8%. ethanol yielded 13.58%. The results for non-specific parameters showed that drying shrinkage was 4.2%, water content was 1.80%, and ash content was 1.4%. The results of the microbial contamination test were 3.9x colonies/ml while the total mold/yeast contamination was 3.1x colonies/ml. Based at the results of studies that has been carried out, Moringa leaf simplicia from Luwung village has met the requirements of specific and non-specific parameters, so that the simplicia may be used as raw material for medication.
{"title":"STANDARISASI SIMPLISIA DAUN KELOR (Moringa oleifera L.) DARI DESA LUWUNG SIDOARJO DENGAN MENGGUNAKAN PENGERINGAN FOOD DEHYDRATOR","authors":"Mella Azizah, A. Ningsih, Butet Sinaga","doi":"10.36656/jpfh.v5i1.1034","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1034","url":null,"abstract":"One of the vegetation that may be used each as meals and medication is the Moringa plant (Moringa oleifera L.). Empirically, Moringa leaves have many advantages and had been proven to be powerful in treating numerous diseases, consisting of diabetes, hepatitis, heart ailment and excessive cholesterol. The chemical parts contained on this plant are terpenoids, tannins, steroids, polyphenols, and alkaloids. This look at aims to pick out medicinal uncooked substances the use of the meals dehydrator drying method whilst on the equal time making sure the drug raw materials, so that the standardization can be accounted for for its quality. Standardization is done by setting specific and non-specific parameters. This study uses descriptive qualitative and quantitative analysis methods. The sample of this research was taken from Luwung village, Sidoarjo regency. The results of standardization for specific parameters showed the determination of the flavonoid content of 16,08±3,62 mgQE/g, the TLC test showed stains in the form of yellow-green fluorescence under UV light at 366 nm, the water-soluble extract test yielded 7.8%, and the water-soluble extract test yielded 7.8%. ethanol yielded 13.58%. The results for non-specific parameters showed that drying shrinkage was 4.2%, water content was 1.80%, and ash content was 1.4%. The results of the microbial contamination test were 3.9x colonies/ml while the total mold/yeast contamination was 3.1x colonies/ml. Based at the results of studies that has been carried out, Moringa leaf simplicia from Luwung village has met the requirements of specific and non-specific parameters, so that the simplicia may be used as raw material for medication.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75787723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis, involving sebaceous glands, follicular hyperkeratosis, bacterial overgrowth, immune and inflammatory responses. Objective: This formulate the ethanol extract of banana peel and pineapple peel into cream preparations and to test the effective antibacterial activity of the combination of banana peel and pineapple peel ethanol extract cream against Propionibacterium acnes. Methods: This research was conducted experimentally with maceration extraction using 70% ethanol as solvent. Acne cream is made with a concentration ratio between (Banana peel: Pineapple peel) namely F1 (Cream Base), F2 (5%:15%), F3 (7.5%:12.5%), F4 (10%:10% ), F5 (12.5%:7.5%), F6 (15%;5%), F7 (20%:0%) and F8 (0%;20%). Then, the physical stability test was carried out in the form of organoleptic test, viscosity test, pH test, homogeneity test, spreadability test and cream type test. Followed by testing the bacteria Propionibacterium acnes in Na media. Results: The antibacterial activity test on F3 showed that the diameter of 20.18 mm was relatively larger than F1 of 0mm, F2 of 18.63 mm, F4 of 18.38 mm, F5 of 16.48 mm, F6 of 18.28 mm, F7 of 13.91 mm and The F8 is 16.11 mm. Conclusion: Cream preparations from formula 1 to formula 8 the cream stability organoleptic test, viscosity test, pH test, homogeneity test, test spreadability and cream type test. The cream preparation in formula 3 has the widest diameter for antibacterial activity compared to other formulas.
{"title":"FORMULASI SEDIAAN CREAM DAN UJI AKTIVITAS ANTIBAKTERI PADA EKSTRAK ETANOL KOMBINASI KULIT PISANG (Musa paradisiaca) DAN KULIT NANAS (Ananas comosus) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium acnes","authors":"Pintata Sembiring","doi":"10.36656/jpfh.v5i1.1065","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1065","url":null,"abstract":"Background: Acne vulgaris is a chronic inflammatory skin disease with a complex pathogenesis, involving sebaceous glands, follicular hyperkeratosis, bacterial overgrowth, immune and inflammatory responses. Objective: This formulate the ethanol extract of banana peel and pineapple peel into cream preparations and to test the effective antibacterial activity of the combination of banana peel and pineapple peel ethanol extract cream against Propionibacterium acnes. Methods: This research was conducted experimentally with maceration extraction using 70% ethanol as solvent. Acne cream is made with a concentration ratio between (Banana peel: Pineapple peel) namely F1 (Cream Base), F2 (5%:15%), F3 (7.5%:12.5%), F4 (10%:10% ), F5 (12.5%:7.5%), F6 (15%;5%), F7 (20%:0%) and F8 (0%;20%). Then, the physical stability test was carried out in the form of organoleptic test, viscosity test, pH test, homogeneity test, spreadability test and cream type test. Followed by testing the bacteria Propionibacterium acnes in Na media. Results: The antibacterial activity test on F3 showed that the diameter of 20.18 mm was relatively larger than F1 of 0mm, F2 of 18.63 mm, F4 of 18.38 mm, F5 of 16.48 mm, F6 of 18.28 mm, F7 of 13.91 mm and The F8 is 16.11 mm. Conclusion: Cream preparations from formula 1 to formula 8 the cream stability organoleptic test, viscosity test, pH test, homogeneity test, test spreadability and cream type test. The cream preparation in formula 3 has the widest diameter for antibacterial activity compared to other formulas.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"61 22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87782568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Papaya stems (Carica papaya L.) are experimentally utilized by the community as new vegetables. Dried papaya stems contain auxiliary metabolites of flavonoids, tannins, glycosides, polyphenols, steroids and triterpenoids. This compound acts as an antioxidant. The flavonoid compounds found in papaya stems act as analgesics. The point of this ponder was to look at the pain relieving impact of papaya stems on male rats initiated by warm plate. Making wounds on creatures by implies of warming plates made with a estimate of 1cm x 1cm. The hair on the mice's backs was shaved, a warming cushion was connected to the mice's backs for around 2 seconds until they come to the dermis and fundamental tissue, causing the skin to rankle and peel in a few places. Pain relieving perceptions in test creatures were given after acceptance by regulating CMC-Na, paracetamol, papaya stem ethanol extricate at measurements of 100 mg/kgBW, 300 mg/kgBW and 600 mg/kgBW. Papaya stem extricate contains auxiliary metabolites of flavonoids, tannins and saponins that act as analgesics. At a measurements of 600 mg/kg body weight, the extricate had an pain relieving impact comparable to that of paracetamol.
{"title":"E EFEKTIVITAS ANALGETIK EKSTRAK BATANG PEPAYA (Carica papaya L.)PADA MENCIT JANTAN YANG DIINDUKSI LEMPENG PANAS","authors":"S. Rahmi","doi":"10.36656/jpfh.v5i1.984","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.984","url":null,"abstract":"Papaya stems (Carica papaya L.) are experimentally utilized by the community as new vegetables. Dried papaya stems contain auxiliary metabolites of flavonoids, tannins, glycosides, polyphenols, steroids and triterpenoids. This compound acts as an antioxidant. The flavonoid compounds found in papaya stems act as analgesics. The point of this ponder was to look at the pain relieving impact of papaya stems on male rats initiated by warm plate. Making wounds on creatures by implies of warming plates made with a estimate of 1cm x 1cm. The hair on the mice's backs was shaved, a warming cushion was connected to the mice's backs for around 2 seconds until they come to the dermis and fundamental tissue, causing the skin to rankle and peel in a few places. Pain relieving perceptions in test creatures were given after acceptance by regulating CMC-Na, paracetamol, papaya stem ethanol extricate at measurements of 100 mg/kgBW, 300 mg/kgBW and 600 mg/kgBW. Papaya stem extricate contains auxiliary metabolites of flavonoids, tannins and saponins that act as analgesics. At a measurements of 600 mg/kg body weight, the extricate had an pain relieving impact comparable to that of paracetamol.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77883555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Swamedikasi merupakan upaya diri untuk menggunakan atau memperoleh obat tanpa diagnosis, resep, pengawasan ataupun konsultasi dengan dokter untuk mengobati suatu penyakit ringan tertentu. Penelitian ini bertujuan Untuk mendeskripsikan pengetahuan dan upaya mahasiswa Fakultas Kesehatan Masyarakat UIN Sumatera Utara Medan. Penelitian ini merupakan penelitian kuantitatif deskriptif menggunakan menggunakan metode survey. Pengumpulan data dilakukan dengan kuesioner via google form yang selanjutnya dianalisis untuk dapat mendeskripsikan hasil penelitian. Hasil penelitian menunjukkan bahwa tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik dimana 52,7% mahasiswa belum familiar dengan istilah swamedikasi dan hanya 25,9% yang mengetahui bahwa antibiotik harus dibeli dengan resep dokter. Upaya swamedikasi mahasiswa termasuk kategori baik karena 62,5% mahasiswa melakukan upaya swamedikasi jika mengalami sakit ringan, 43,8% mengetahui aturan pakai obat dari apoteker/asisten apoteker dan 52,7% mengetahuinya dari kemasan obat. Penelitian ini juga menunjukkan bahwa mahasiswa telah melakukan persiapan swamedikasi dengan cara menyimpan obat yang akan digunakan saat mereka sakit. Kesimpulan dari penelitian ini adalah tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik (36,6%) dan upaya swamedikasi termasuk kategori baik (80,36%). Obat yang paling banyak disimpan sebagai persiapan swamedikasi adalah obat penurun demam (82,1%).
{"title":"GAMBARAN PENGETAHUAN DAN UPAYA SWAMEDIKASI MAHASISWA FAKULTAS KESEHATAN MASYARAKAT UIN SUMATERA UTARA MEDAN","authors":"W. Wahyudi","doi":"10.36656/jpfh.v5i1.1057","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1057","url":null,"abstract":"Swamedikasi merupakan upaya diri untuk menggunakan atau memperoleh obat tanpa diagnosis, resep, pengawasan ataupun konsultasi dengan dokter untuk mengobati suatu penyakit ringan tertentu. Penelitian ini bertujuan Untuk mendeskripsikan pengetahuan dan upaya mahasiswa Fakultas Kesehatan Masyarakat UIN Sumatera Utara Medan. Penelitian ini merupakan penelitian kuantitatif deskriptif menggunakan menggunakan metode survey. Pengumpulan data dilakukan dengan kuesioner via google form yang selanjutnya dianalisis untuk dapat mendeskripsikan hasil penelitian. Hasil penelitian menunjukkan bahwa tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik dimana 52,7% mahasiswa belum familiar dengan istilah swamedikasi dan hanya 25,9% yang mengetahui bahwa antibiotik harus dibeli dengan resep dokter. Upaya swamedikasi mahasiswa termasuk kategori baik karena 62,5% mahasiswa melakukan upaya swamedikasi jika mengalami sakit ringan, 43,8% mengetahui aturan pakai obat dari apoteker/asisten apoteker dan 52,7% mengetahuinya dari kemasan obat. Penelitian ini juga menunjukkan bahwa mahasiswa telah melakukan persiapan swamedikasi dengan cara menyimpan obat yang akan digunakan saat mereka sakit. Kesimpulan dari penelitian ini adalah tingkat pengetahuan swamedikasi mahasiswa FKM UIN Sumatera Utara termasuk kategori kurang baik (36,6%) dan upaya swamedikasi termasuk kategori baik (80,36%). Obat yang paling banyak disimpan sebagai persiapan swamedikasi adalah obat penurun demam (82,1%).","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88064743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypercholesterolemia is a condition that cholesterol in the blood increases beyond the normal which is one of the risk factors for cardiovascular disease. Arabica coffee leaves are part of the arabica coffee plant which contains flavonoid, saponin, mangiferin, chlorogenic acid which are thought to reduce cholesterol levels in the blood. This study aims to determine the antihypercholesterolemia effectiveness of arabica coffee leaves ethanol extract (ACLEE) in male rats induced by a high-fat diet. The test of antihypercholesterolemia effectiveness used male rats induced by a high-fat diet as test animals. The study used 25 rats and divided into 5 groups : negative control (CMC-Na 0.5%), positive control (simvastatin 0.9 mg/kgBW), ACLEE 200 mg/kgBW, ACLEE 300 mg/kgBW and ACLEE 400 mg/kgBW. Total cholesterol were measured by the CHOD-PAP method. The data obtained were analyzed statistically used one way Anova. The results of statistical analysis showed that there was a significant difference between negative control with positive control, ACLEE 200, 300 and 400 mg/kgBW (p-value<0.05). The decrease in total cholesterol levels increased in line with the increase in the dose of arabica coffee leaves ethanol extract. The most effective of ACLEE as antihypercholesterolemia was ACLEE 400 mg/kgBW. There was no significant difference between positive control and ACLEE 400 mg/kgBW (p.>0.05). Based on the results of statistical analysis, it can be concluded that the arabica coffee leaves ethanol extract has antihypercholesterolemic effect in rats.
{"title":"A ntihypercholesterolemia UJI EFEKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK DAUN KOPI ARABIKA (Coffea arabica L.) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) YANG DIINDUKSI DIET TINGGI LEMAK","authors":"Linta Meliala","doi":"10.36656/jpfh.v5i1.1063","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1063","url":null,"abstract":"Hypercholesterolemia is a condition that cholesterol in the blood increases beyond the normal which is one of the risk factors for cardiovascular disease. Arabica coffee leaves are part of the arabica coffee plant which contains flavonoid, saponin, mangiferin, chlorogenic acid which are thought to reduce cholesterol levels in the blood. This study aims to determine the antihypercholesterolemia effectiveness of arabica coffee leaves ethanol extract (ACLEE) in male rats induced by a high-fat diet. The test of antihypercholesterolemia effectiveness used male rats induced by a high-fat diet as test animals. The study used 25 rats and divided into 5 groups : negative control (CMC-Na 0.5%), positive control (simvastatin 0.9 mg/kgBW), ACLEE 200 mg/kgBW, ACLEE 300 mg/kgBW and ACLEE 400 mg/kgBW. Total cholesterol were measured by the CHOD-PAP method. The data obtained were analyzed statistically used one way Anova. The results of statistical analysis showed that there was a significant difference between negative control with positive control, ACLEE 200, 300 and 400 mg/kgBW (p-value<0.05). The decrease in total cholesterol levels increased in line with the increase in the dose of arabica coffee leaves ethanol extract. The most effective of ACLEE as antihypercholesterolemia was ACLEE 400 mg/kgBW. There was no significant difference between positive control and ACLEE 400 mg/kgBW (p.>0.05). Based on the results of statistical analysis, it can be concluded that the arabica coffee leaves ethanol extract has antihypercholesterolemic effect in rats. \u0000 ","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77618372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anggun Syafitri, B. Lubis, Jhan Saberlan Purba, Sri Sudewi Pratiwi Sitio, Efrata Sembiring, Yunita Syaputri Damanik
Quality health services are health services that can satisfy every user of health services in accordance with the level of satisfaction. Satisfaction will occur if the expectations of the patient can be met by the services provided by the hospital so that it needs to be considered continuously the satisfaction and expectations of the patient. The purpose of this study was to determine the level of satisfaction of outpatients of BPJS Kesehatan participants with pharmaceutical services at the outpatient Pharmacy Installation at RSU Sembiring. The design of this study used descriptive survey research. The population in this study was 1400 patients, and the sample was 93 patients using the Slovin formula. Data collected through primary and secondary data and using univariant and bivariant analysis with the help of the SPSS computer program. The results of the chi square test obtained variables related to the satisfaction of outpatients at the general hospital, namely: Physical evidence (p value = 0.002), Reliability (p value = 0.000, Responsiveness (p value = 0.002), Guarantee (p value = 0.004), and Empathy (p value = 0.000). It is recommended to the Outpatient Pharmacy of Sembiring General Hospital to maintain a good quality of service and continue to improve the quality of service to patients.
{"title":"ANALISIS TINGKAT KEPUASAN PASIEN ANALISIS TINGKAT KEPUASAN PASIEN RAWAT JALAN PESERTA BPJS KESEHATAN TERHADAP PELAYANAN FARMASI DI INSTALASI RSU SEMBIRING","authors":"Anggun Syafitri, B. Lubis, Jhan Saberlan Purba, Sri Sudewi Pratiwi Sitio, Efrata Sembiring, Yunita Syaputri Damanik","doi":"10.36656/jpfh.v5i1.1020","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1020","url":null,"abstract":"Quality health services are health services that can satisfy every user of health services in accordance with the level of satisfaction. Satisfaction will occur if the expectations of the patient can be met by the services provided by the hospital so that it needs to be considered continuously the satisfaction and expectations of the patient. The purpose of this study was to determine the level of satisfaction of outpatients of BPJS Kesehatan participants with pharmaceutical services at the outpatient Pharmacy Installation at RSU Sembiring. \u0000The design of this study used descriptive survey research. The population in this study was 1400 patients, and the sample was 93 patients using the Slovin formula. Data collected through primary and secondary data and using univariant and bivariant analysis with the help of the SPSS computer program. \u0000The results of the chi square test obtained variables related to the satisfaction of outpatients at the general hospital, namely: Physical evidence (p value = 0.002), Reliability (p value = 0.000, Responsiveness (p value = 0.002), Guarantee (p value = 0.004), and Empathy (p value = 0.000). It is recommended to the Outpatient Pharmacy of Sembiring General Hospital to maintain a good quality of service and continue to improve the quality of service to patients.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87156475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Some diseases caused by microorganisms on the hands are diarrhea, diphteria, boils, typhus and others. The bacteria that most often contaminate the skin of the hands are Staphylococcus aureus and Escheria coli, whose spreas most often transmitted from hand to hand. Bunga lawing are one of the medicinal plants that have been used in medicine. The purpose of this study was determine the antibacterial activity of gel hand essential oil sanitizer gel preparation (Illiacium verum Hook.f) to the growth of Staphylococcus aureus and Escheria coli bacteria compared to sanitizer Dettol gel hand. This was carried out with the experimental method. Essential oil of bunga lawing is extracted using a heat method, namely soxhletation. The antibacterial activity test in this study used the agar diffusion method (disc diffusion). The measurement of the diameter of the inhibited area formed were analyzed using a one-way ANOVA statistical test. The results of antibacterial activity of bunga lawang sanitizer hand have lower antibacterial activity gel hand sanitizer Dettol. In the diameter of Staphylococcus aureus bacteria the highest rate 0f hand flower sanitizer gel was 15,1 mm while the sanitizer gel hand wash 21,4 mm. In Escheria coli bacteria, the inhibitory diameter the sanitizer hand gel dettol was obtained at 20.1 mm, while the lawang handsanitizer gel obtained the highest inhibition diameter of 13.1 mm. The results of data analysis using a one-way ANOVA statistical test showed a sig value p<0,05 so that there were significant differences between the gel hand to the inhibitory power of the growth of Staphylococcus aureus and Escheria coli bacteria. Keywords: Bunga lawang, hand sanitizer gel, Staphylococcus aureus, Escherichia coli
手部微生物引起的疾病有腹泻、白喉、疖疮、斑疹伤寒等。最常污染手部皮肤的细菌是金黄色葡萄球菌和大肠杆菌，它们最常通过手对手传播。邦加草是一种药用植物，已被用于医学。本研究的目的是测定凝胶手精油洗手液凝胶制剂(Illiacium verum Hook.f)对金黄色葡萄球菌和大肠杆菌生长的抑菌活性，并与洁手露洗手液凝胶进行比较。这是用实验方法进行的。龙齿苋精油的提取采用热法，即索氏法。本实验采用琼脂扩散法(圆盘扩散法)进行抑菌活性试验。形成的抑制区直径的测量采用单因素方差分析统计检验。结果表明，本加旺洗手液的抗菌活性低于凝胶洗手液滴露的抗菌活性。在金黄色葡萄球菌细菌直径中，手花洗手液凝胶的检出率最高为15.1 mm，洗手液凝胶的检出率最高为21.4 mm。在大肠杆菌中，洗手液凝胶滴液的抑制直径为20.1 mm，而劳旺洗手液凝胶的抑制直径最高，为13.1 mm。数据分析结果采用单因素方差分析统计检验，p< 0.05，说明凝胶手对金黄色葡萄球菌和大肠杆菌生长的抑制能力有显著差异。关键词:邦加旺，洗手液凝胶，金黄色葡萄球菌，大肠杆菌
{"title":"UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER SANITIZER BUNGA LAWANG (Illiacium verum Hook. f) pada BAKTERI Staphylococcus aureus & Escherichia coli","authors":"N. Marbun","doi":"10.36656/jpfh.v5i1.855","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.855","url":null,"abstract":"Abstract \u0000Some diseases caused by microorganisms on the hands are diarrhea, diphteria, boils, typhus and others. The bacteria that most often contaminate the skin of the hands are Staphylococcus aureus and Escheria coli, whose spreas most often transmitted from hand to hand. Bunga lawing are one of the medicinal plants that have been used in medicine. The purpose of this study was determine the antibacterial activity of gel hand essential oil sanitizer gel preparation (Illiacium verum Hook.f) to the growth of Staphylococcus aureus and Escheria coli bacteria compared to sanitizer Dettol gel hand. This was carried out with the experimental method. Essential oil of bunga lawing is extracted using a heat method, namely soxhletation. The antibacterial activity test in this study used the agar diffusion method (disc diffusion). The measurement of the diameter of the inhibited area formed were analyzed using a one-way ANOVA statistical test. The results of antibacterial activity of bunga lawang sanitizer hand have lower antibacterial activity gel hand sanitizer Dettol. In the diameter of Staphylococcus aureus bacteria the highest rate 0f hand flower sanitizer gel was 15,1 mm while the sanitizer gel hand wash 21,4 mm. In Escheria coli bacteria, the inhibitory diameter the sanitizer hand gel dettol was obtained at 20.1 mm, while the lawang handsanitizer gel obtained the highest inhibition diameter of 13.1 mm. The results of data analysis using a one-way ANOVA statistical test showed a sig value p<0,05 so that there were significant differences between the gel hand to the inhibitory power of the growth of Staphylococcus aureus and Escheria coli bacteria. \u0000 \u0000Keywords: Bunga lawang, hand sanitizer gel, Staphylococcus aureus, Escherichia coli","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80775663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The need to maintain endurance during the Covid-19 pandemic has increased the intensity of people consuming herbal medicine. The Qusthul Hindi herbal medicine comes from the qust plant. This plant has the potential to treat various human ailments, including respiratory, digestive, and metabolic disorders. Making herbal medicine that is still very simple allows herbal medicine to be contaminated by microbes. This study aims to identify the presence of Coliform microbial contamination and E. coli bacteria in Qusthul Hindi herbal preparations circulating in the market. The five samples of Qusthul Hindi herbal medicine used in this study were obtained from several shops in Indonesian e-commerce. The Coliform microbial contamination test was conducted using the Most Probable Number (MPN) method. The MPN test consists of 2 stages: a presumptive test using Lactose Broth media and a confirmed test using Escherichia coli Broth media. MPN calculation is based on the number of positive test tubes. Positive test tube observations can be seen by observing the emergence of turbidity or the formation of gas contained in the Durham tube. The MPN value is calculated from the combination of positive tubes in the MPN table. The identification of Escherichia coli was tested using Eosin Methylene Blue Agar (EMBA) selective media, and then gram staining was performed. From the results of the estimator test, confirmatory test, selective medium test to gram staining, it showed that five Qusthul Hindi herbs tested were positively contaminated by Coliform microbes and all samples showed positive results for Escherichia coli contamination.
{"title":"UJI CEMARAN MIKROBA Coliform DAN IDENTIFIKASI Escherichia coli PADA SEDIAAN JAMU QUSTHUL HINDI YANG BEREDAR DI PASARAN","authors":"Amelia Rahmawati Nengsih","doi":"10.36656/jpfh.v5i1.995","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.995","url":null,"abstract":"The need to maintain endurance during the Covid-19 pandemic has increased the intensity of people consuming herbal medicine. The Qusthul Hindi herbal medicine comes from the qust plant. This plant has the potential to treat various human ailments, including respiratory, digestive, and metabolic disorders. Making herbal medicine that is still very simple allows herbal medicine to be contaminated by microbes. This study aims to identify the presence of Coliform microbial contamination and E. coli bacteria in Qusthul Hindi herbal preparations circulating in the market. The five samples of Qusthul Hindi herbal medicine used in this study were obtained from several shops in Indonesian e-commerce. The Coliform microbial contamination test was conducted using the Most Probable Number (MPN) method. The MPN test consists of 2 stages: a presumptive test using Lactose Broth media and a confirmed test using Escherichia coli Broth media. MPN calculation is based on the number of positive test tubes. Positive test tube observations can be seen by observing the emergence of turbidity or the formation of gas contained in the Durham tube. The MPN value is calculated from the combination of positive tubes in the MPN table. The identification of Escherichia coli was tested using Eosin Methylene Blue Agar (EMBA) selective media, and then gram staining was performed. From the results of the estimator test, confirmatory test, selective medium test to gram staining, it showed that five Qusthul Hindi herbs tested were positively contaminated by Coliform microbes and all samples showed positive results for Escherichia coli contamination.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76672673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alternative larvicides against Aedes aegypti larvae and safe for the environment, one of which is cinnamon oil which has been shown to have a larvicidal effect on larvae. Cinnamon contains flavonoid compounds which are strongly suspected to have a larvicidal effect. It can be said that this research is to determine the effectiveness of extracts from cinnamon as a larvicide against the death of Aedes aegypti mosquito larvae. And for the extraction method used in this study using the maceration method. For a concentration of 2% it can kill a total of 32 (53%) larvae, and for a concentration of 4% it can kill 43 (72%) total lava, and a concentration of 6% can kill 53 (88%) larvae, and for a positive control, namely abate (temephos). ) has the best larvicidal effect with an average % larval mortality of 100% within 1 hour. Cinnamon extract test treatments with a concentration of 2% (2ml/100ml) experienced larval death 32 (43%), and for a concentration of 4% (4ml/100ml) experienced larvae mortality 43 (53%). and for a concentration of 6%, 53 (88%) larvae died. And for temephos, it was able to kill a total of all larvae, while for negative control it did not die. The most effective concentration of cinnamon extract in killing larvae was 6%, the higher the concentration, the higher the larval mortality value.
{"title":"EVALUASI UJI EFEKTIVITAS EKSTRAK KAYU MANIS (Cinnamomum burmanni) SEBAGAI LARVASIDA TERHADAP KEMATIAN JENTIK NYAMUK (Aedes aegypti)","authors":"I. R.","doi":"10.36656/jpfh.v5i1.1001","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1001","url":null,"abstract":"Alternative larvicides against Aedes aegypti larvae and safe for the environment, one of which is cinnamon oil which has been shown to have a larvicidal effect on larvae. Cinnamon contains flavonoid compounds which are strongly suspected to have a larvicidal effect. It can be said that this research is to determine the effectiveness of extracts from cinnamon as a larvicide against the death of Aedes aegypti mosquito larvae. And for the extraction method used in this study using the maceration method. For a concentration of 2% it can kill a total of 32 (53%) larvae, and for a concentration of 4% it can kill 43 (72%) total lava, and a concentration of 6% can kill 53 (88%) larvae, and for a positive control, namely abate (temephos). ) has the best larvicidal effect with an average % larval mortality of 100% within 1 hour. Cinnamon extract test treatments with a concentration of 2% (2ml/100ml) experienced larval death 32 (43%), and for a concentration of 4% (4ml/100ml) experienced larvae mortality 43 (53%). and for a concentration of 6%, 53 (88%) larvae died. And for temephos, it was able to kill a total of all larvae, while for negative control it did not die. The most effective concentration of cinnamon extract in killing larvae was 6%, the higher the concentration, the higher the larval mortality value.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84801679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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