Red and green leaves of the pucuk merah (Syzygium myrtifolium Walp.) contain flavonoids, saponins, and tannins which have the potential as antioxidants. The purpose is test out the antioxidant activity of red leaves and green leaves infusions of red shoots (S. myrtifolium). Test material is extracted using infusion method. The testing of antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The free radical concentration of DPPH was analyzed using UV-Vis spectrophotometer after addition of various concentrations of S. myrtifolium leaves infusion extracts. Various concentrations of S. myrtafolium leaves infusion extracts used were 20 ppm; 10 ppm; 5 ppm; 2.5 ppm; 1.25 ppm; 0.625 ppm. Vitamin C solutions as the positive control were prepared on 5; 2.5; 1.25; 0,625; 0.3125 ppm. The result of the experiment showed the thick red and green leaf extract has IC50 value of 11,130 ppm and 10,522 ppm. The antioxidant activity of green leaf extract is higher than the red leaf extract. Research on green leaves extract of S. myrtafolium is suggested for further research as anticancer.
{"title":"Antioxidant Test of Red and Green Colored-Leaves Infusions of Pucuk Merah (Syzygium myrtifolium Walp.) with DPPH method","authors":"Desy Muliana Wenas, Putrisa Anggun Meilani, Herdini Herdini","doi":"10.36656/jpfh.v5i1.969","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.969","url":null,"abstract":"Red and green leaves of the pucuk merah (Syzygium myrtifolium Walp.) contain flavonoids, saponins, and tannins which have the potential as antioxidants. The purpose is test out the antioxidant activity of red leaves and green leaves infusions of red shoots (S. myrtifolium). Test material is extracted using infusion method. The testing of antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The free radical concentration of DPPH was analyzed using UV-Vis spectrophotometer after addition of various concentrations of S. myrtifolium leaves infusion extracts. Various concentrations of S. myrtafolium leaves infusion extracts used were 20 ppm; 10 ppm; 5 ppm; 2.5 ppm; 1.25 ppm; 0.625 ppm. Vitamin C solutions as the positive control were prepared on 5; 2.5; 1.25; 0,625; 0.3125 ppm. The result of the experiment showed the thick red and green leaf extract has IC50 value of 11,130 ppm and 10,522 ppm. The antioxidant activity of green leaf extract is higher than the red leaf extract. Research on green leaves extract of S. myrtafolium is suggested for further research as anticancer.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88678463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Duku leaves (Lansium domesticum Corr.) can be used as an alternative treatment for skin-related diseases such as boils caused by Stapylococcus aureus. Duku leaves contain flavonoids, saponins and triterpenoids that are able to provide antibacterial effects. This study aims to formulate duku leaf extract intopreparations lotion antibacterialagainst Stapylococcus aureus. The study was conducted experimentally, the sample was extracted by maceration method, then the extract was formulated intopreparations lotion with concentrations of 4%, 8% and 12%, of the three concentrations compared with positive control (caladin), negative control (basis lotion), then evaluation was carried out in the form organoleptic test, homogeneity test, dispersion test, pH test, irritation test and hedonic test for each formulation. After the evaluation data was obtained, an antibacterial test was carried out for each formulation. Then proceed with statistical analysis method One Way Anova. The results obtained at a concentration of 4% have the best formula in terms of organoleptic and hedonic (attractive color), thick shape, smells of perfume). In terms of pH it has a pH of 7.0; spreadability (6.27 cm ± 0.4); There is no irritation in this formulation. Based on statistical analysis, the sig Anova value of P < 0.05 (0.000) showed that there was a difference between each formulation in the concentration variation when compared to the positive control. Based on the antibacterial test the formulation concentration of 12% had the best antibacterial properties, namely 16.82 mm ± 4.00 compared to other formulations and the positive control had the best antibacterial properties, namely 17.32 mm ± 1.58. Based on statistical analysis, sig P value < 0.05 (0.000) which means that there are differences in each antibacterial formulation when compared with positive controls. The results showed that in terms of formulation, lotion with a concentration of 4% was the best formulation compared to other formulas. Based on antibacterial lotion concentration of 12% has the best antibacterial properties compared to other formulas.
{"title":"FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN LOTION EKSTRAK ETANOL DAUN DUKU (Lansium domesticum Corr.) TERHADAP BAKTERI Staphylococcus Aureus PADA PENYEMBUHAN PENYAKIT KULIT BERNANAH TAHUN 2022","authors":"S. Sulasmi","doi":"10.36656/jpfh.v4i2.870","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.870","url":null,"abstract":"Duku leaves (Lansium domesticum Corr.) can be used as an alternative treatment for skin-related diseases such as boils caused by Stapylococcus aureus. Duku leaves contain flavonoids, saponins and triterpenoids that are able to provide antibacterial effects. This study aims to formulate duku leaf extract intopreparations lotion antibacterialagainst Stapylococcus aureus. The study was conducted experimentally, the sample was extracted by maceration method, then the extract was formulated intopreparations lotion with concentrations of 4%, 8% and 12%, of the three concentrations compared with positive control (caladin), negative control (basis lotion), then evaluation was carried out in the form organoleptic test, homogeneity test, dispersion test, pH test, irritation test and hedonic test for each formulation. After the evaluation data was obtained, an antibacterial test was carried out for each formulation. Then proceed with statistical analysis method One Way Anova. The results obtained at a concentration of 4% have the best formula in terms of organoleptic and hedonic (attractive color), thick shape, smells of perfume). In terms of pH it has a pH of 7.0; spreadability (6.27 cm ± 0.4); There is no irritation in this formulation. Based on statistical analysis, the sig Anova value of P < 0.05 (0.000) showed that there was a difference between each formulation in the concentration variation when compared to the positive control. Based on the antibacterial test the formulation concentration of 12% had the best antibacterial properties, namely 16.82 mm ± 4.00 compared to other formulations and the positive control had the best antibacterial properties, namely 17.32 mm ± 1.58. Based on statistical analysis, sig P value < 0.05 (0.000) which means that there are differences in each antibacterial formulation when compared with positive controls. The results showed that in terms of formulation, lotion with a concentration of 4% was the best formulation compared to other formulas. Based on antibacterial lotion concentration of 12% has the best antibacterial properties compared to other formulas.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"-1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85404429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5% NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . The results are hydrolyzed with α-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102. The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102.
商用纤维素微晶称为Avicel PH 102，这是一种片剂填充材料，Avicel PH 102价格昂贵且用量很大，有必要寻找其他替代来源生产微晶纤维素。香蕉茎废弃物的含水量为80-90%，纤维素含量为63-64%，半纤维素含量为20%，木质素含量为5%，其他成分含量为11-12%，可作为制备MCC的基础原料。本研究旨在从香蕉茎中分离α-纤维素，并用Avicel PH 102对微晶纤维素进行表征。这项研究的方法是实验性的。用4%的NaOH溶解木质素，将香蕉茎粉加热，2.5% NaOCl漂白，17.5% NaOH加热溶解β-纤维素和γ-纤维素，HCL 2 N加热，得到微晶香蕉茎纤维素。结果经α-纤维素水解，再经2.5N HCl水解得到微晶纤维素，并与Avicel PH102进行了表征和比较。对香蕉茎微晶纤维素和Avicel PH 102分别进行了感官测试，结果为粗粉，白色，无任何气味;pH 6.6和6.5;物质在水中的溶解度0.023和0.023%;总灰分分别为0.17和0.12%;干燥降低5.47%和5.28%;实密度0.337、0.404 g / cm3;真型重量1.43和1.43 g / cm3;不可压缩密度0.478和0.480 g / cm3;压缩指数分别为41.77和18.85%;Hausner指数分别为1.41和1.18;孔隙度;76.43和93.640%。研究结果表明，以香蕉茎为原料制备的微晶纤维素具有与Avicel PH 102相同的特性。
{"title":"PEMBUATAN MIKROKRISTALIN SELULOSA (MCC) dari BATANG PISANG MAS (Musa acuminata colla) dengan AVICEL PH 102 SEBAGAI PEMBANDING TAHUN 2019","authors":"Erdiwan Erdiwan","doi":"10.36656/jpfh.v4i2.866","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.866","url":null,"abstract":"Commercial cellulose microcrystalline known as Avicel PH 102, which is a tablet filling material Avicel PH 102 which is expensive and uses a lot of it, it is necessary to look for other alternative sources of producing microcrystalline cellulose. The Waste of banana stem contains water content of 80-90%, cellulose 63-64%, hemicellulose 20%, and lignin 5% and contains 11-12% other constituens so that it can be the basic material for making MCC. This study aimed to isolate α-cellulose from banana mas stems and characterize microcrystalline cellulose with Avicel PH 102. The method of this study was an experimental. Microcrystalline banana stem cellulose is obtained by heating banana stem powder with 4% NaOH which serves to dissolve lignin, then bleached with 2.5% NaOCl, 17.5% NaOH heated to dissolve β-cellulose and γ-cellulose, and heated with HCL 2 N . The results are hydrolyzed with α-cellulose and then hydrolyzed with 2.5N HCl to give microcrystalline cellulose, which is characterized and compared to Avicel PH102. The result of characterization of banana mas stem microcrystalline cellulose and Avicel PH 102 which were obtained respectively is organoleptic tests of coarse powder, white, doesn’t have any smells; pH 6.6 and 6.5; solubility of substances in water 0.023 and 0.023%; total ash content are 0.17 and 0.12%; decrease of drying 5.47 and 5.28%; real density 0.337 and 0.404 g / cm3; true type weight 1.43 and 1.43 g / cm3; incompressible density 0.478 and 0.480 g / cm3; compressibility index 41.77 and 18.85%; Hausner index 1.41 and 1.18; porosity; 76.43 and 93.640%. Based on the results of the study concluded that microcrystalline cellulose can be made from banana mas stems and has the same characteristics as Avicel PH 102.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86544458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Guava plants contain psiditanin “eugenol” essential oil, tannis, flavonoids, saponins, alkaloids. Compounds that have very good strength come from the class of flavanoids, vitamin C which can be usedas a facial cleanser. This study aims to determine the preparation of peel gel mask of guava leaf extract is effective as a facial cleanser and to find out the peel off gel mask of guava leaf extract can irritate the skin of volunteers. The made with 4 formulation with concentrations of 0%, 10%, 15%, 20%. The testing of the peel off gel mask formulation ethanol extract on cleanliness was carried out with the analysis of the ms. Excel bar diagram. The results showed that (psidium guajava L) contain flavonoid, alkaloids, tannins and saponins. The results of the characteristics of the simplicia powder were 5,42% water content 9,56% total ash content 0,34% acid insoluble ash, ethanol soluble extract 64,295. The results of the peel off gel mask formulation test with a cleanliness test on the panelists facial skin concentration of 15% included in the category can clean the panelist’s facial skin.Guava leaf ethanol extract has a facial cleansing activitywith a score of 3
{"title":"FORMULASI SEDIAAN MASKER Gel Peel Off EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium Guajava L.) SEBAGAI PEMBERSIH WAJAH","authors":"P. Tarigan","doi":"10.36656/jpfh.v4i2.862","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.862","url":null,"abstract":"Guava plants contain psiditanin “eugenol” essential oil, tannis, flavonoids, saponins, alkaloids. Compounds that have very good strength come from the class of flavanoids, vitamin C which can be usedas a facial cleanser. This study aims to determine the preparation of peel gel mask of guava leaf extract is effective as a facial cleanser and to find out the peel off gel mask of guava leaf extract can irritate the skin of volunteers. The made with 4 formulation with concentrations of 0%, 10%, 15%, 20%. The testing of the peel off gel mask formulation ethanol extract on cleanliness was carried out with the analysis of the ms. Excel bar diagram. The results showed that (psidium guajava L) contain flavonoid, alkaloids, tannins and saponins. The results of the characteristics of the simplicia powder were 5,42% water content 9,56% total ash content 0,34% acid insoluble ash, ethanol soluble extract 64,295. The results of the peel off gel mask formulation test with a cleanliness test on the panelists facial skin concentration of 15% included in the category can clean the panelist’s facial skin.Guava leaf ethanol extract has a facial cleansing activitywith a score of 3 \u0000 ","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89937227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Hypertension is one of a disease high prevalence in the world today, often called the silent killer because it generally does not cause symptoms in sufferers. This disease is characterized by increased contraction of blood vessels which increases blood pressure against the walls of blood vessels. Mengkudu (Morinda citrifolia) is one of the most widely grown plants in Indonesia which has effective antihypertensive properties. Previous studies have shown that mengkudu can lower blood pressure significantly compared to negative controls. The purpose of writing this article is to make a literature review that comprehensively discusses the effectiveness of mengkudu as an antihypertensive from previous studies that have been carried out. Methods: The writing of this article uses the literature review method on research articles found in the Google Scholar and Science Direct database using the keywords mengkudu, Morinda Citrifolia, hypertension and blood pressure. The criteria for the selected articles are articles published between 2000-2022 in both national and international journals. Literature review was conducted by comparing research methods, processing methods and the results obtained from each article. Results: The results of previous studies showed that mengkudu had a significant effect on reducing blood pressure. The decrease in blood pressure is related to the content of prexeronin (endothelial vasoactive), scopoletin (causing vasodilation) and xeronine (diuretic effect) contained in mengkudu which can lower blood pressure by different mechanisms. Conlusion: The content of mengkudu has the potential as an antihypertensive because it can significantly lower blood pressure.
{"title":"BUAH MENGKUDU (Morinda citrifolia), KANDUNGAN DAN EFEKTIVITASNYA SEBAGAI ANTIHIPERTENSI: LITERATURE REVIEW","authors":"W. Wahyudi","doi":"10.36656/jpfh.v4i2.871","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.871","url":null,"abstract":"Background: Hypertension is one of a disease high prevalence in the world today, often called the silent killer because it generally does not cause symptoms in sufferers. This disease is characterized by increased contraction of blood vessels which increases blood pressure against the walls of blood vessels. Mengkudu (Morinda citrifolia) is one of the most widely grown plants in Indonesia which has effective antihypertensive properties. Previous studies have shown that mengkudu can lower blood pressure significantly compared to negative controls. The purpose of writing this article is to make a literature review that comprehensively discusses the effectiveness of mengkudu as an antihypertensive from previous studies that have been carried out. \u0000Methods: The writing of this article uses the literature review method on research articles found in the Google Scholar and Science Direct database using the keywords mengkudu, Morinda Citrifolia, hypertension and blood pressure. The criteria for the selected articles are articles published between 2000-2022 in both national and international journals. Literature review was conducted by comparing research methods, processing methods and the results obtained from each article. \u0000Results: The results of previous studies showed that mengkudu had a significant effect on reducing blood pressure. The decrease in blood pressure is related to the content of prexeronin (endothelial vasoactive), scopoletin (causing vasodilation) and xeronine (diuretic effect) contained in mengkudu which can lower blood pressure by different mechanisms. \u0000Conlusion: The content of mengkudu has the potential as an antihypertensive because it can significantly lower blood pressure.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91157400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of natural hair dyes is a solution to the problem of synthetic hair dyes. one of the plants such as beetroot contains a lot of secondary metabolites, one of which is flavonoids which can provide specific dyes. The natural color found in beetroot can be used as a natural dye in cosmetics. To find out at what concentration the beetroot produces the most optimal quality physical color of the hair dye preparation. This research method was carried out including making beetroot (Beta vulgaris L.) ethanol extract by maceration for 5 days with 95% ethanol solvent and continued remeseration with the same solvent. The extract formula used was 10%, 15%, and 20% physical evaluation carried out included organoleptic test, irritation test, pH test, homogeneity test, stability test for washing, stability test for sunlight. As a result of inspection of the three hair dye cream formulations, the formulations met the requirements of the test formulations. The results of the hair tack test showed that it gave a good color at a density of 20% time. In the color stability test of the wash after 15 shampoo washes, all three formulations have a fixed color up to 9 washes. Also, in terms of color stability to sunlight, after exposure to direct sunlight, the color appears to change slightly, making the hair darker than before. The result of the concentration of beetroot ethanol extract that gives the best color is a concentration of 20%.
{"title":"Formulasi Dan Evaluasi Sediaan Krim Pewarna Rambut Dari Ekstrak Etanol Umbi Bit (Beta vulgaris L.)","authors":"Sarah Damayanti","doi":"10.36656/jpfh.v4i2.869","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.869","url":null,"abstract":"The use of natural hair dyes is a solution to the problem of synthetic hair dyes. one of the plants such as beetroot contains a lot of secondary metabolites, one of which is flavonoids which can provide specific dyes. The natural color found in beetroot can be used as a natural dye in cosmetics. To find out at what concentration the beetroot produces the most optimal quality physical color of the hair dye preparation. This research method was carried out including making beetroot (Beta vulgaris L.) ethanol extract by maceration for 5 days with 95% ethanol solvent and continued remeseration with the same solvent. The extract formula used was 10%, 15%, and 20% physical evaluation carried out included organoleptic test, irritation test, pH test, homogeneity test, stability test for washing, stability test for sunlight. As a result of inspection of the three hair dye cream formulations, the formulations met the requirements of the test formulations. The results of the hair tack test showed that it gave a good color at a density of 20% time. In the color stability test of the wash after 15 shampoo washes, all three formulations have a fixed color up to 9 washes. Also, in terms of color stability to sunlight, after exposure to direct sunlight, the color appears to change slightly, making the hair darker than before. The result of the concentration of beetroot ethanol extract that gives the best color is a concentration of 20%.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72877574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The existence of competition between chemical and traditional drugs has resulted in increasingly being displaced from the market. In addition, another problem that traditional medicine has not been widely used for both self-medication and formal health services is that most of the efficacy of traditional medicine has not been scientifically tested. Therefore, it is very important to do an analysis through research. The purpose of this study was to determine the efficacy of traditional medicine PT. Amanah Berkah Kencana in improving health and body immunity. The research method used in this study is a descriptive method with a cross- sectional approach. The main informants in this study were consumers of traditional medicine PT. Amanah Berkah Kencana. This research was conducted in North Sumatra from December 2021 to February 2022. The results of the study explain that 82.5% strongly agree. The results of this percentage show a very good picture for consumers who use Haseda traditional medicine in maintaining health and increasing human immunity. The remaining 17.5% do not agree because of lack of public education and knowledge about the use and benefits of traditional medicine for health. For health observers, there should be socialization to the public about the use of traditional medicines.
{"title":"ANALISIS SALAH SATU OBAT HERBAL DI SUMATERA UTARA TAHUN 2021","authors":"Christivo Tambusai, Nerdy Nerdy, Firdaus Fahdi","doi":"10.36656/jpfh.v4i2.852","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.852","url":null,"abstract":"The existence of competition between chemical and traditional drugs has resulted in increasingly being displaced from the market. In addition, another problem that traditional medicine has not been widely used for both self-medication and formal health services is that most of the efficacy of traditional medicine has not been scientifically tested. Therefore, it is very important to do an analysis through research. The purpose of this study was to determine the efficacy of traditional medicine PT. Amanah Berkah Kencana in improving health and body immunity. The research method used in this study is a descriptive method with a cross- sectional approach. The main informants in this study were consumers of traditional medicine PT. Amanah Berkah Kencana. This research was conducted in North Sumatra from December 2021 to February 2022. \u0000The results of the study explain that 82.5% strongly agree. The results of this percentage show a very good picture for consumers who use Haseda traditional medicine in maintaining health and increasing human immunity. The remaining \u000017.5% do not agree because of lack of public education and knowledge about the use and benefits of traditional medicine for health. \u0000For health observers, there should be socialization to the public about the use of traditional medicines.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85422048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cosmetics have been known to humans since centuries ago. Since the last 40 years, cosmetics has grown rapidly. Quantias and the quality of biological materials for use on the skin are increasing. Blush on is created from attractive colors and of course using coloring agents. Purple cabbage extract is used as a dye in blush on with a concentration of 30% and Isopropyl myristate as a binder with various concentrations of 0.5%, 1.0% and 2.0%. Purple cabbage extract was obtained by 96% ethanol maceration, then filtered and rotary using a rotary evaporator, then evaporated in a water bath with a temperature of 700 C. Blush on is made by pressing. The extract yield obtained was 18.68%. The observations show that preparations with a concentration of Isopropyl myristate 1.0% are better and more preferable because the preparation is not brittle and not too hard. In the pH test, all dosages meet the requirements. In the irritation test, all preparations did not cause irritation reactions to all panelists. Purple cabbage extract can be used as a natural dye in the process of making blush on and the best concentration of Isopropyl myristate is 1.0%.
{"title":"FORMULASI SEDIAAN BLUSH ON DARI EKSTRAK KUBIS UNGU (Brassica Oleracea L. var. capitates f. rubra) SEBAGAI PEWARNA DALAM BENTUK COMPACT POWDER","authors":"Nadia Nadia","doi":"10.36656/jpfh.v4i2.861","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.861","url":null,"abstract":"Cosmetics have been known to humans since centuries ago. Since the last 40 years, cosmetics has grown rapidly. Quantias and the quality of biological materials for use on the skin are increasing. Blush on is created from attractive colors and of course using coloring agents. Purple cabbage extract is used as a dye in blush on with a concentration of 30% and Isopropyl myristate as a binder with various concentrations of 0.5%, 1.0% and 2.0%. Purple cabbage extract was obtained by 96% ethanol maceration, then filtered and rotary using a rotary evaporator, then evaporated in a water bath with a temperature of 700 C. Blush on is made by pressing. The extract yield obtained was 18.68%. The observations show that preparations with a concentration of Isopropyl myristate 1.0% are better and more preferable because the preparation is not brittle and not too hard. In the pH test, all dosages meet the requirements. In the irritation test, all preparations did not cause irritation reactions to all panelists. Purple cabbage extract can be used as a natural dye in the process of making blush on and the best concentration of Isopropyl myristate is 1.0%.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84680009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chinese betel leaf (Peperomiapellucida) is one among the wild herbaceous plants belonging to the Piperaceae family which is employed as a natural medicine. The study's goal was to determine the antibacterial activity of an ethanol extract of Chinese betel leaf ointment against Staphylococcus aureus, as well as the optimal concentration. The test of the study was administered by the diffusion method using disc paper. The results of the characterization examination of Chinese betel leaf simplicia powder obtained water soluble extract content of 64.58%, ethanol soluble extract content of 24.95%, total ash content of three 3.2%, 5.9 % water of content and 0.28% acid insoluble ash content of and Simplisia contains alkaloids, flavonoids, tannins, and saponins. Staphylococcus aureus obtained a degree of 8% with a diameter of 16.81, the diameter of the inhibition zone of the Chinese betel leaf ethanol extract against. The ethanol extract of Chinese betel leaf exhibits antibacterial action against Staphylococcus aureus, according to the findings of the study. Keywords: Antibacterial activity, Chinese betel leaf Staphylococcus aureus
{"title":"FORMULASI DAN UJI AKTIVITAS ANTI BAKTERI SEDIAAN SALEP EKSTRAK ETANOL DAUN SIRIH CINA (peperomia pellucida) TERHADAP BAKTERI Staphylococcus Aureus","authors":"R. Sari","doi":"10.36656/jpfh.v4i2.856","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.856","url":null,"abstract":"Chinese betel leaf (Peperomiapellucida) is one among the wild herbaceous plants belonging to the Piperaceae family which is employed as a natural medicine. The study's goal was to determine the antibacterial activity of an ethanol extract of Chinese betel leaf ointment against Staphylococcus aureus, as well as the optimal concentration. The test of the study was administered by the diffusion method using disc paper. The results of the characterization examination of Chinese betel leaf simplicia powder obtained water soluble extract content of 64.58%, ethanol soluble extract content of 24.95%, total ash content of three 3.2%, 5.9 % water of content and 0.28% acid insoluble ash content of and Simplisia contains alkaloids, flavonoids, tannins, and saponins. Staphylococcus aureus obtained a degree of 8% with a diameter of 16.81, the diameter of the inhibition zone of the Chinese betel leaf ethanol extract against. The ethanol extract of Chinese betel leaf exhibits antibacterial action against Staphylococcus aureus, according to the findings of the study. \u0000Keywords: Antibacterial activity, Chinese betel leaf Staphylococcus aureus","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82400919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piroxicam is an anti-inflammatory drug belonging to the NSAID group and is also used as an analgesic and anti-rheumatic drug. Its use is often combined with stomach medicines, as the side effects of piroxicam can irritate the stomach. One of them is omeprazole. Since piroxicam and omeprazole act on the same enzyme, CYP450, they can affect the pharmacokinetic profile, especially at the metabolic stage and excretion of piroxicam. The purpose of this study was to determine the effect of omeprazole on the pharmacokinetic profile of piroxicam especially in the metabolic phase and excretion. The method used in this study was an experimental method using three male rabbits. These rabbits are divided into three groups. The first treatment group was giving pyroxicam solution 0.653 mg / kg body weight, the second treatment group gave piroxicam 0.653 mg / kg body weight that one hour before was given omeprazole 1.2 mg / kg body weight and the third group treated with piroxicam 0.7 mg / kg body weight at the same time with omeprazole 1,4 mg / kg body weight. Plasma levels of the drug piroxicam are measured using a high performance liquid chromatography (HPLC) tool. The verification method is executed. This is the determination of LOD and LOQ values, accuracy and accuracy testing. The result of data analysis using t-table. The results showed that there was an increase or difference in pharmacokinetic parameter values during the absorption phase, but no significant effect was shown for each group. Pharmacokinetic parameter values for metabolic stages and excretion were reduced and no significant difference was shown between the groups. Simultaneous administration of omeprazole and piroxicam and administration of piroxicam 1 hour before omeprazole may inhibit piroxicam-metabolizing enzymes and thus affect pharmacokinetic parameters and excretion during absorption, but are not significant.
{"title":"Pengaruh Pemberian Omeprazole Terhadap Profil Farmakokinetika Piroxicam Dengan Metode Kromatografi Cair Kinerja Tinggi (KCKT)","authors":"Dasma Arihan Nauli Sipayung","doi":"10.36656/jpfh.v4i2.867","DOIUrl":"https://doi.org/10.36656/jpfh.v4i2.867","url":null,"abstract":"Piroxicam is an anti-inflammatory drug belonging to the NSAID group and is also used as an analgesic and anti-rheumatic drug. Its use is often combined with stomach medicines, as the side effects of piroxicam can irritate the stomach. One of them is omeprazole. Since piroxicam and omeprazole act on the same enzyme, CYP450, they can affect the pharmacokinetic profile, especially at the metabolic stage and excretion of piroxicam. The purpose of this study was to determine the effect of omeprazole on the pharmacokinetic profile of piroxicam especially in the metabolic phase and excretion. The method used in this study was an experimental method using three male rabbits. These rabbits are divided into three groups. The first treatment group was giving pyroxicam solution 0.653 mg / kg body weight, the second treatment group gave piroxicam 0.653 mg / kg body weight that one hour before was given omeprazole 1.2 mg / kg body weight and the third group treated with piroxicam 0.7 mg / kg body weight at the same time with omeprazole 1,4 mg / kg body weight. Plasma levels of the drug piroxicam are measured using a high performance liquid chromatography (HPLC) tool. The verification method is executed. This is the determination of LOD and LOQ values, accuracy and accuracy testing. The result of data analysis using t-table. The results showed that there was an increase or difference in pharmacokinetic parameter values during the absorption phase, but no significant effect was shown for each group. Pharmacokinetic parameter values for metabolic stages and excretion were reduced and no significant difference was shown between the groups. Simultaneous administration of omeprazole and piroxicam and administration of piroxicam 1 hour before omeprazole may inhibit piroxicam-metabolizing enzymes and thus affect pharmacokinetic parameters and excretion during absorption, but are not significant. \u0000 ","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90280867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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