Audi Ichsani Aribowo, Bunga Nur Annisa, Nena Vauziah Sary, Lina Nurfadhila, Marsah Rahmawati Utami
Heavy metals are defined as the transition elements that have a high atomic mass, are toxic, and cannot be broken down by living organisms. Metal Lead (Pb) is one of the heavy metals which are widely distributed in the environment. Heavy metal lead is one of the causes of serious health problems because it can cause disturbances to the human body. Therefore, the aim of this literature review is to present an illustration and up-to-date data on the analytical methods used for food and beverages contaminated with lead heavy metal (Pb). The methodology of this research is a literature review study from several databases such as Science Direct, Pubmed, and Google Scholar with a limitation of publication in the last 10 years. The results of a literature review from the analysis of Pb metal contamination in food and beverages, there are several techniques that can be utilized to analyze and various factors that cause the amount of lead (Pb) levels such as the atomic absorption spectrophotometer (AAS) method.
{"title":"ANALISIS CEMARAN LOGAM BERAT TIMBAL (Pb) PADA MAKANAN DAN MINUMAN : STUDI LITERATUR","authors":"Audi Ichsani Aribowo, Bunga Nur Annisa, Nena Vauziah Sary, Lina Nurfadhila, Marsah Rahmawati Utami","doi":"10.36656/jpfh.v5i1.1038","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1038","url":null,"abstract":"Heavy metals are defined as the transition elements that have a high atomic mass, are toxic, and cannot be broken down by living organisms. Metal Lead (Pb) is one of the heavy metals which are widely distributed in the environment. Heavy metal lead is one of the causes of serious health problems because it can cause disturbances to the human body. Therefore, the aim of this literature review is to present an illustration and up-to-date data on the analytical methods used for food and beverages contaminated with lead heavy metal (Pb). The methodology of this research is a literature review study from several databases such as Science Direct, Pubmed, and Google Scholar with a limitation of publication in the last 10 years. The results of a literature review from the analysis of Pb metal contamination in food and beverages, there are several techniques that can be utilized to analyze and various factors that cause the amount of lead (Pb) levels such as the atomic absorption spectrophotometer (AAS) method.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81866121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Inflamation is the body’s defense mechanism in response to tissue injury and interference by external factors. Pearl grass (Hedyotis Corymbosa L.Lamk) is one of Rubiaceae family. Pearl grass have efficacy in the treatment as anti-inflamatory, anti-diabetic, anti-bacteria, and antioxidant. Pearl grass contains flavonoids has pharmacological effects as a anti-inflamatory. The purpose of this study was to determine the anti-inflamatory effect of ethanolic extract of pearl grass (EERM) on white rats incuded by λ- carragenan.This research was conducted by experimental method which included pearl grass extraction, phytochemical screening, and anti-inflamatory activity test of ethanolic of pearl gras with paw edema method using digital plethysmometer. As experimental animals 15 rats were divided into 5 groups, each group were 3 rats. As an inductor λ-carragenan 1 % was administered intraplantar. Sodium carboxy methyl cellulose (Na-CMC) 0,5 % as negative control, 2,25 mg/kg bw diclofenac dose as positif control and ethanolic extract of pearl grass dose 100 mg/kg bw, dose 200 mg/kg bw, and dose of 400 mg/kg bw as a test material given orally. Observations were made for 6 hours. The test data were analyzed statistically using one way ANOVA and continuced with Tukey’s B.The results of phytochemical indicated that ethanolic extract of pearl grass contained alkaloids, flavanoid, saponins, tanin and glycosides. The dosage of ethanolic extract of pearl grass 100 mg/kg bw, dose 200 mg/kg bw, dose 400 mg/kg bw has the effect as anti-inflamatory. The effective dose of ethanol extract of pearl grass as an anti-inflamatory in white rats was 400 mg/kg bw.
{"title":"UJI AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RUMPUT MUTIARA (Hedyotis corymbosa L. Lamk) TERHADAP TIKUS PUTIH","authors":"Rani Ardiani","doi":"10.36656/jpfh.v5i1.858","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.858","url":null,"abstract":"Inflamation is the body’s defense mechanism in response to tissue injury and interference by external factors. Pearl grass (Hedyotis Corymbosa L.Lamk) is one of Rubiaceae family. Pearl grass have efficacy in the treatment as anti-inflamatory, anti-diabetic, anti-bacteria, and antioxidant. Pearl grass contains flavonoids has pharmacological effects as a anti-inflamatory. The purpose of this study was to determine the anti-inflamatory effect of ethanolic extract of pearl grass (EERM) on white rats incuded by λ- carragenan.This research was conducted by experimental method which included pearl grass extraction, phytochemical screening, and anti-inflamatory activity test of ethanolic of pearl gras with paw edema method using digital plethysmometer. As experimental animals 15 rats were divided into 5 groups, each group were 3 rats. As an inductor λ-carragenan 1 % was administered intraplantar. Sodium carboxy methyl cellulose (Na-CMC) 0,5 % as negative control, 2,25 mg/kg bw diclofenac dose as positif control and ethanolic extract of pearl grass dose 100 mg/kg bw, dose 200 mg/kg bw, and dose of 400 mg/kg bw as a test material given orally. Observations were made for 6 hours. The test data were analyzed statistically using one way ANOVA and continuced with Tukey’s B.The results of phytochemical indicated that ethanolic extract of pearl grass contained alkaloids, flavanoid, saponins, tanin and glycosides. The dosage of ethanolic extract of pearl grass 100 mg/kg bw, dose 200 mg/kg bw, dose 400 mg/kg bw has the effect as anti-inflamatory. The effective dose of ethanol extract of pearl grass as an anti-inflamatory in white rats was 400 mg/kg bw.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89912413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There is a trend of "back to nature" which has become the lifestyle of today's society, so that people return to using various natural ingredients in medicine. A drug side effect is any adverse and unwanted response to a drug that occurs at doses normally used in humans for the treatment of disease, diagnosis, prevention, or modification of physiological function. Pharmacovigilance is carried out with the aim of monitoring drug safety by detecting an increase in the incidence of Advers Drugs Reaction (ADR). This review was conducted to see an overview of the initial data/reports on the relationship between the use of herbal medicines and the incidence of ADR. As a result, it is known that the percentage of ADR events in various places is 19%, 12%, 13.36% and 10-15% with possible and probable categories. The types of herbal medicines used are white turmeric, fitsea, garcia, ginger water, turmeric, herbalife, niran, calcusol, vegeta, tensigard, diapet, herbal vegeta, diabetes herbs, hypertension herbs, cholesterol herbs, kidney stone herbs, anti-inflammatory analgesic herbs, herbal medicine for asthma and herbal medicine for diarrhea.
{"title":"STUDI FARMAKOVIGILANS PADA OBAT HERBAL","authors":"Cantika Nurul Sa’adah","doi":"10.36656/jpfh.v5i1.1067","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1067","url":null,"abstract":"There is a trend of \"back to nature\" which has become the lifestyle of today's society, so that people return to using various natural ingredients in medicine. A drug side effect is any adverse and unwanted response to a drug that occurs at doses normally used in humans for the treatment of disease, diagnosis, prevention, or modification of physiological function. Pharmacovigilance is carried out with the aim of monitoring drug safety by detecting an increase in the incidence of Advers Drugs Reaction (ADR). This review was conducted to see an overview of the initial data/reports on the relationship between the use of herbal medicines and the incidence of ADR. As a result, it is known that the percentage of ADR events in various places is 19%, 12%, 13.36% and 10-15% with possible and probable categories. The types of herbal medicines used are white turmeric, fitsea, garcia, ginger water, turmeric, herbalife, niran, calcusol, vegeta, tensigard, diapet, herbal vegeta, diabetes herbs, hypertension herbs, cholesterol herbs, kidney stone herbs, anti-inflammatory analgesic herbs, herbal medicine for asthma and herbal medicine for diarrhea.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"270 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77149187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug abuse is defined as the use of one or more types of drugs without medical regulations or not according to indications so that it has various side effects, including physical, psychological, and social dysfunction. One of the drugs that are often used by the public is amphetamine because amphetamine causes euphoria and a sense of calm (psychotropic group). Hence, the purpose of this literature review is to provide an overview and the most recent information regarding the effects of amphetamine use. The method for this literature analysis is by evaluating references from Science Direct, PubMed, and Google Scholar, with a publication restriction of the previous 10 years. Based on the relevant literature, amphetamine misuse has diverse impacts on its users. Drug abuse has psychological and physical effects on adolescents (students) to adults and affects a person's social interactions.
{"title":"PENYALAHGUNAAN AMFETAMIN DAN DAMPAK PENGGUNA TERHADAP KESEHATAN DAN SOSIAL : LITERATURE REVIEW","authors":"Bunga Nur Annisa, Indah Laily Hilmi, S. Salman","doi":"10.36656/jpfh.v5i1.1060","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1060","url":null,"abstract":"Drug abuse is defined as the use of one or more types of drugs without medical regulations or not according to indications so that it has various side effects, including physical, psychological, and social dysfunction. One of the drugs that are often used by the public is amphetamine because amphetamine causes euphoria and a sense of calm (psychotropic group). Hence, the purpose of this literature review is to provide an overview and the most recent information regarding the effects of amphetamine use. The method for this literature analysis is by evaluating references from Science Direct, PubMed, and Google Scholar, with a publication restriction of the previous 10 years. Based on the relevant literature, amphetamine misuse has diverse impacts on its users. Drug abuse has psychological and physical effects on adolescents (students) to adults and affects a person's social interactions.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"336 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76468200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study was to determine that the ethanolic extract of rambutan leaves (Nephelium lappaceum L) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. As an antibacterial comparator used Amoxicillin. Each leaf of sample was extracted with maceration methode using 70% of ethanol solvent. Where it 2 to 3 days with several stirring times then it filtered, then the filtrate result was thickened with vacuum rotary evaporator. The antibacterial activity test used the paper disc diffusion method and was observed based on the diameter of the inhibition zone or the clear zone formed around the paper discs and slots which used with three times treatments. Result test of antibacterial activity of rambutan leaf ethanol extract (Nephelium lappaceum L) with these method showed that the extract actively inhibited the growth of Staphylococcus aureus bacteria with Minimum Inhibitory Concentration (MIC)3.125% with a 7.96 mm, but not showed for the growth of Escherichia coli bacteria.
{"title":"Uji Aktivitas Antibakteri Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L) Pada Pertumbuhan Bakteri Staphylococcus aureus dan Escherichia coli","authors":"Nina Irmayanti Harahap","doi":"10.36656/jpfh.v5i1.936","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.936","url":null,"abstract":"The purpose of this study was to determine that the ethanolic extract of rambutan leaves (Nephelium lappaceum L) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. As an antibacterial comparator used Amoxicillin. Each leaf of sample was extracted with maceration methode using 70% of ethanol solvent. Where it 2 to 3 days with several stirring times then it filtered, then the filtrate result was thickened with vacuum rotary evaporator. The antibacterial activity test used the paper disc diffusion method and was observed based on the diameter of the inhibition zone or the clear zone formed around the paper discs and slots which used with three times treatments. Result test of antibacterial activity of rambutan leaf ethanol extract (Nephelium lappaceum L) with these method showed that the extract actively inhibited the growth of Staphylococcus aureus bacteria with Minimum Inhibitory Concentration (MIC)3.125% with a 7.96 mm, but not showed for the growth of Escherichia coli bacteria.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"288 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79412940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Red spinach has function as skin antiseptic. It has antibacterial activity because it contains compounds such as tannins, flavonoids, saponins, and steroids. The purpose of formulation and test of antibacterial activity of hand sanitizer gel preparation red spinach extract and evaluation of physical quality of hand sanitizer. Antibacterial activity test was measured by diffusion method using paper disk to measuring the diameter of the bacterial growth inhibition zone of Escherichia coli and Staphylococcus aureus. Concentration extract ethanol of leaf red spinach (and formula of hand sanitizer gel used (F1) blanco; (F2) 5%; (F3) 10%; (F4) 20% and (F5) control positive/detol. Evaluation of physical properties of hand sanitizer gel include of: homogeneity test, stability test and pH test. The results has found showed that antibacterial activity test of gel extract leaves red spinach (on Escherichia coli inhibited at without extract/blanco was 0 mm, concentration of 5% with diameter of inhibit was 14,99 mm, concentration of 10% with diameter of inhibit was 17,26 mm, concentration of 20% with diameter of inhibit was 18,26 mm and using control positive was 19.33. And then for bacteri Staphylococcus aures at concentration of without extract/blanco was 0 mm, 5% with diameter of inhibit was 15,5 mm, concentration of 10% with diameter of inhibit was 15,96 mm and concentration of 20% with diameter of inhibit was 17,43 mm and using control positive was 18.33 mm. So we can conclude that hand sanitizer gel of leaf red spinach have less inhibited growth against Escherichia coli and Staphylococcus aureus.
红菠菜具有皮肤防腐剂的作用。它具有抗菌活性，因为它含有单宁、类黄酮、皂苷和类固醇等化合物。目的:制备红菠菜提取物洗手液凝胶，测定其抗菌活性，评价洗手液的物理质量。采用纸片扩散法测定抑菌活性，测定大肠杆菌和金黄色葡萄球菌的抑菌带直径。叶红菠菜浓缩提取物乙醇(及使用的洗手液凝胶配方(F1);(F2) 5%;(F3) 10%;(F4) 20%和(F5)控制阳性/苯胺。对洗手液凝胶物理性能的评价包括:均匀性试验、稳定性试验和pH值试验。结果发现，菠菜叶红凝胶提取物对无提取物/白衣酶抑制的大肠杆菌的抑菌活性为0 mm, 5%浓度抑制直径为14、99 mm, 10%浓度抑制直径为17、26 mm, 20%浓度抑制直径为18、26 mm，对照阳性为19.33。对金黄色葡萄球菌，无提取物/白粉浓度为0 mm, 5%抑制直径为15.5 mm, 10%抑制直径为15.96 mm, 20%抑制直径为17.43 mm，对照阳性为18.33 mm。由此可见，叶红菠菜洗手液对大肠杆菌和金黄色葡萄球菌的抑制作用较弱。
{"title":"FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI SEDIAAN GEL HAND SANITIZER EKSTRAK ETANOL DAUN BAYAM MERAH (Amaranthus Tricolor L.) TERHADAP BAKTERI Staphylococcus aureus & Eschericia coli","authors":"Zola Efa Harnis","doi":"10.36656/jpfh.v5i1.939","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.939","url":null,"abstract":"Red spinach has function as skin antiseptic. It has antibacterial activity because it contains compounds such as tannins, flavonoids, saponins, and steroids. The purpose of formulation and test of antibacterial activity of hand sanitizer gel preparation red spinach extract and evaluation of physical quality of hand sanitizer. Antibacterial activity test was measured by diffusion method using paper disk to measuring the diameter of the bacterial growth inhibition zone of Escherichia coli and Staphylococcus aureus. Concentration extract ethanol of leaf red spinach (and formula of hand sanitizer gel used (F1) blanco; (F2) 5%; (F3) 10%; (F4) 20% and (F5) control positive/detol. Evaluation of physical properties of hand sanitizer gel include of: homogeneity test, stability test and pH test. The results has found showed that antibacterial activity test of gel extract leaves red spinach (on Escherichia coli inhibited at without extract/blanco was 0 mm, concentration of 5% with diameter of inhibit was 14,99 mm, concentration of 10% with diameter of inhibit was 17,26 mm, concentration of 20% with diameter of inhibit was 18,26 mm and using control positive was 19.33. And then for bacteri Staphylococcus aures at concentration of without extract/blanco was 0 mm, 5% with diameter of inhibit was 15,5 mm, concentration of 10% with diameter of inhibit was 15,96 mm and concentration of 20% with diameter of inhibit was 17,43 mm and using control positive was 18.33 mm. So we can conclude that hand sanitizer gel of leaf red spinach have less inhibited growth against Escherichia coli and Staphylococcus aureus.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90944839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gambir (Uncaria gambir. Roxb) contains flavonoids, tannins, saponins and alkaloids that can help heal wounds. One of the main ingredients that gambir contains is catechins . Catechins are flavonoid compounds with anti-inflammatory, antioxidant and antibacterial properties derived from Gambir. This study aimed to compare wound healing time between ethanolic extracts of 70% gambir resin gel (Uncaria gambir. Roxb) with betadin preparations in male Sprague dawley rats (Rattus norvegicus). A total of 9 white rats (Rattus norvegicus) strain Sprague dawley were divided into 3 groups, a negative control group for gel base treatment and a positive control group for gambir sap gel preparations (Uncaria gambir. Roxb) betadine comparison group. This study was conducted by experimental method with a post-trial controlled group design. Each group is colored with group preparations, the treatment is carried out 3 × 1 every day. Wound healing time was analyzed by a one-way Anova test on spss. Healing ingroup I was 10.6 days, in group II, 10.3 days in group III and 9.3 days.
{"title":"Uji UJI EFEKTIVITAS GEL EKSTRAK ETANOL 70% GETAH GAMBIR (Uncaria gambir. Roxb) dan BETADINE TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR","authors":"S. Sulasmi","doi":"10.36656/jpfh.v5i1.1078","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1078","url":null,"abstract":"Gambir (Uncaria gambir. Roxb) contains flavonoids, tannins, saponins and alkaloids that can help heal wounds. One of the main ingredients that gambir contains is catechins . Catechins are flavonoid compounds with anti-inflammatory, antioxidant and antibacterial properties derived from Gambir. This study aimed to compare wound healing time between ethanolic extracts of 70% gambir resin gel (Uncaria gambir. Roxb) with betadin preparations in male Sprague dawley rats (Rattus norvegicus). A total of 9 white rats (Rattus norvegicus) strain Sprague dawley were divided into 3 groups, a negative control group for gel base treatment and a positive control group for gambir sap gel preparations (Uncaria gambir. Roxb) betadine comparison group. This study was conducted by experimental method with a post-trial controlled group design. Each group is colored with group preparations, the treatment is carried out 3 × 1 every day. Wound healing time was analyzed by a one-way Anova test on spss. Healing ingroup I was 10.6 days, in group II, 10.3 days in group III and 9.3 days.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90361810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evi Depiana Gultom, Herti Ayu N Zebua, Robiatun Rambe
The antipyretic effect of flavonoid in senduduk leaf (Melastoma malabathricum L.) is one of the traditional medicines that people used. The goal of this study is to determine the antipyretic effect of the extract of Senduduk leaf (Melastoma malabathricum L.) in male white mice and compare it to paracetamol. The design of this experimental study was a post-test only controlled group design. Twenty-five Wistar furrow mice, aged two months and weighing 200 grams, were utilized as animal models. The mice were divided into five groups, one of which was the negative control group (2 ml water), First dosage of Senduduk leaf extract (100 mg/200 g body weight mice), second dose of the extract (200 mg/200 g body weight mice), and third dose of the extract (300 mg/200 g body weight mice). Temperature measurements were taken before and after the DPT vaccination was administered to mice, and every 30 minutes post treatment until 150 minutes. The result after observing treatment at 30 minutes for dose I (37.930C), dose II (37.760C), and dose III (37.450C). The results at 150 minutes for dose I (37,470C), for dose II (37,150C), and for dose III (36.880C). The result of the research was to analyzed using the one way ANOVA test. The results of statistical observations using the one way ANOVA method showed the significant value was p < 0.05 (0.000). This indicates there are differences from each treatment in antipyretic testing. If continued with the Tukey test, a significant value of p> 0.05 (0.9480), the research concluded that there is no difference in terms of antipyretic testing at a dose of 300mg/KgBW compared to paracetamol. The research concluded is the EEDS at a dose of 300mg/KgBW has the best antipyretic properties compared to paracetamol.
{"title":"UJI EFEK ANTIPIRETIK DAUN SENDUDUK (Melastoma malabathricum L.) PADA TIKUS PUTIH JANTAN (Rattus Norvegicus)","authors":"Evi Depiana Gultom, Herti Ayu N Zebua, Robiatun Rambe","doi":"10.36656/jpfh.v5i1.972","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.972","url":null,"abstract":"The antipyretic effect of flavonoid in senduduk leaf (Melastoma malabathricum L.) is one of the traditional medicines that people used. The goal of this study is to determine the antipyretic effect of the extract of Senduduk leaf (Melastoma malabathricum L.) in male white mice and compare it to paracetamol. The design of this experimental study was a post-test only controlled group design. Twenty-five Wistar furrow mice, aged two months and weighing 200 grams, were utilized as animal models. The mice were divided into five groups, one of which was the negative control group (2 ml water), First dosage of Senduduk leaf extract (100 mg/200 g body weight mice), second dose of the extract (200 mg/200 g body weight mice), and third dose of the extract (300 mg/200 g body weight mice). Temperature measurements were taken before and after the DPT vaccination was administered to mice, and every 30 minutes post treatment until 150 minutes. The result after observing treatment at 30 minutes for dose I (37.930C), dose II (37.760C), and dose III (37.450C). The results at 150 minutes for dose I (37,470C), for dose II (37,150C), and for dose III (36.880C). The result of the research was to analyzed using the one way ANOVA test. The results of statistical observations using the one way ANOVA method showed the significant value was p < 0.05 (0.000). This indicates there are differences from each treatment in antipyretic testing. If continued with the Tukey test, a significant value of p> 0.05 (0.9480), the research concluded that there is no difference in terms of antipyretic testing at a dose of 300mg/KgBW compared to paracetamol. The research concluded is the EEDS at a dose of 300mg/KgBW has the best antipyretic properties compared to paracetamol.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76278677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The garbage problem is a very important problem because it has the potential to damage the balance of the environmental ecosystem. Many studies have been carried out on the content of active compounds in grapefruit peel, but there are differences in sampling locations, types of solvents for extraction, differences in treatment and testing. In the discovery of Eco-enzyme fermentation solution product, Dr. Rosukon Poompanvong to help local farmers to obtain better yields while being friendly to the environment. Eco-Enzyme is a popular fermented fruit peel organic waste which has been developed because it is very practical, economical, and environmentally friendly. Utilization of fruit peels into Eco-Enzyme is an evolution of science in the health sector. This study aims to determine the Eco-Enzyme fermentation process from pomelo peel and Eco-Enzyme acetic acid levels and their potential as antioxidants with experimental research using Eco-Enzyme sample solution with FeCl3 solution as a qualitative test indicator for Eco-Enzyme samples. Quantitative test using 1-2 drops of Eco-Enzyme sample solution 0,1 M NaOH standard solution and phenolphthalein indicator solution in alkalimetric titration and DPPH method with DPPH solution using UV-Vis spectrophotometer. From the results of qualitative research, the results of Eco-Enzyme fermentation are in the form of a light brown solution, have a brick red precipitate, and there is a brick red precipitate. The results of quantitative research on alkalimetric titration of Eco-Enzyme fermentation, there is an acetic acid level of 7.5% per one gram of pomelo peel, and the DPPH method on the fermented Eco-Enyme solution with an IC50 value of 9.418075752 ppm, which means it has very strong antioxidant potential. Eco-enzyme sample solution has acetic acid level of 7,5% per one gram of pomelo peel and has very strong antioxidant potential
垃圾问题是一个非常重要的问题，因为它有可能破坏环境生态系统的平衡。对柚子皮中活性成分的含量进行了大量的研究，但在取样地点、提取溶剂类型、处理方法和检测方法等方面存在差异。在发现生态酵素发酵液产品时，Rosukon Poompanvong博士帮助当地农民在对环境友好的同时获得更好的产量。生态酶是一种很受欢迎的发酵果皮有机废物，因为它具有实用性、经济性和环保性。利用果皮制成生态酶是卫生领域科学的发展。本研究旨在通过实验研究，以Eco-Enzyme样品溶液为研究对象，以FeCl3溶液为Eco-Enzyme样品的定性测试指标，确定Eco-Enzyme发酵过程中柚皮和Eco-Enzyme的乙酸水平及其作为抗氧化剂的潜力。采用1-2滴Eco-Enzyme样品溶液0,1 M NaOH标准溶液和酚酞指示剂溶液进行碱度滴定和DPPH法定量检测，DPPH溶液采用紫外可见分光光度计。从定性研究结果来看，Eco-Enzyme发酵的结果呈浅棕色溶液形式，有砖红色沉淀，有砖红色沉淀。对eco -酵素发酵进行碱度滴定定量研究的结果表明，每克柚皮的乙酸含量为7.5%，DPPH法对发酵后的eco -酵素溶液的IC50值为9.418075752 ppm，具有很强的抗氧化潜力。生态酶样品溶液每克柚皮醋酸含量为7.5%，具有很强的抗氧化潜力
{"title":"ANALISIS KADAR ASAM ASETAT HASIL FERMENTASI ECO-ENZYME DARI KULIT JERUK BALI (Citrus maxima Merr.) DAN POTENSINYA SEBAGAI ANTIOKSIDAN DENGAN METODE ALKALIMETRI DAN DPPH","authors":"B. Sembiring","doi":"10.36656/jpfh.v5i1.1069","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.1069","url":null,"abstract":"The garbage problem is a very important problem because it has the potential to damage the balance of the environmental ecosystem. Many studies have been carried out on the content of active compounds in grapefruit peel, but there are differences in sampling locations, types of solvents for extraction, differences in treatment and testing. In the discovery of Eco-enzyme fermentation solution product, Dr. Rosukon Poompanvong to help local farmers to obtain better yields while being friendly to the environment. Eco-Enzyme is a popular fermented fruit peel organic waste which has been developed because it is very practical, economical, and environmentally friendly. Utilization of fruit peels into Eco-Enzyme is an evolution of science in the health sector. \u0000This study aims to determine the Eco-Enzyme fermentation process from pomelo peel and Eco-Enzyme acetic acid levels and their potential as antioxidants with experimental research using Eco-Enzyme sample solution with FeCl3 solution as a qualitative test indicator for Eco-Enzyme samples. Quantitative test using 1-2 drops of Eco-Enzyme sample solution 0,1 M NaOH standard solution and phenolphthalein indicator solution in alkalimetric titration and DPPH method with DPPH solution using UV-Vis spectrophotometer. \u0000From the results of qualitative research, the results of Eco-Enzyme fermentation are in the form of a light brown solution, have a brick red precipitate, and there is a brick red precipitate. The results of quantitative research on alkalimetric titration of Eco-Enzyme fermentation, there is an acetic acid level of 7.5% per one gram of pomelo peel, and the DPPH method on the fermented Eco-Enyme solution with an IC50 value of 9.418075752 ppm, which means it has very strong antioxidant potential. \u0000Eco-enzyme sample solution has acetic acid level of 7,5% per one gram of pomelo peel and has very strong antioxidant potential","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90892676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Garlic contains flavonoids, tannins, and saponins which act as antifungals. The purpose of this study was to formulate an ethanol extract of garlic (Allium sativum) ointment with various concentrations of 5%, 10%, 15% and to evaluate the ointment preparation with physical evaluation requirements. Testing the activity of the ointment preparation against the fungus Trichophyton mentagrophytes was carried out by the diffusion method. The results showed that garlic (Allium sativum) could be formulated as an antifungal ointment preparation and met the requirements of the ointment preparation evaluation test with the results of the organoleptic test of the white ointment base, the 5% formulation being pale yellow, the 10% formulation and 15% brownish yellow. The homogeneity test showed no lumps in the ointment preparation, the pH test was in accordance with the requirements, namely 4.5-6.5. The dispersion test was in accordance with the requirements, namely 5-7 cm, and the adhesive data test was in accordance with the requirements, which was more than 4 seconds. The results showed that garlic (Allium sativum) ethanol extract ointment could inhibit the fungus Trichophyton mentagrophytes where a concentration of 15% produced an inhibition zone of 10.4500 mm, and as a comparison, miconazole ointment produced an inhibition zone of 14.3833 mm.
{"title":"FORMULASI SEDIAAN SALEP ANTI FUNGI EKSTRAK ETANOL BAWANG PUTIH (Allium sativum) TERHADAP PERTUMBUHAN JAMUR (Tricophyton mentagrophytes) SECARA IN VITRO","authors":"Firdaus Fahdi, Herviani Sari","doi":"10.36656/jpfh.v5i1.990","DOIUrl":"https://doi.org/10.36656/jpfh.v5i1.990","url":null,"abstract":"Garlic contains flavonoids, tannins, and saponins which act as antifungals. The purpose of this study was to formulate an ethanol extract of garlic (Allium sativum) ointment with various concentrations of 5%, 10%, 15% and to evaluate the ointment preparation with physical evaluation requirements. Testing the activity of the ointment preparation against the fungus Trichophyton mentagrophytes was carried out by the diffusion method. The results showed that garlic (Allium sativum) could be formulated as an antifungal ointment preparation and met the requirements of the ointment preparation evaluation test with the results of the organoleptic test of the white ointment base, the 5% formulation being pale yellow, the 10% formulation and 15% brownish yellow. The homogeneity test showed no lumps in the ointment preparation, the pH test was in accordance with the requirements, namely 4.5-6.5. The dispersion test was in accordance with the requirements, namely 5-7 cm, and the adhesive data test was in accordance with the requirements, which was more than 4 seconds. The results showed that garlic (Allium sativum) ethanol extract ointment could inhibit the fungus Trichophyton mentagrophytes where a concentration of 15% produced an inhibition zone of 10.4500 mm, and as a comparison, miconazole ointment produced an inhibition zone of 14.3833 mm.","PeriodicalId":17717,"journal":{"name":"Jurnal Penelitian Farmasi & Herbal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83757760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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