Pub Date : 2022-01-05DOI: 10.31603/pharmacy.v1i1.6093
Nirwati Rusli, Muhammad Azdar Setiawan, Nuraini Hikmawati
Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic,antipireic, and antiplatelet. Aacetosal undegoes cross-first metabolisism (first passeffect) causing low drug bioavailability. The smal lsolubility of acetosal will affectthe rate of absorption which later affect the intensity of treatment, so transdermaldelivery in emulgel dosage forms can be one of. In this study an experimentalmethod was used by formulating an acetosal transdermal emulgel preparation, asa gel base HPMC was used at a concentration of 4%, 4.5%, 5% also variation oftween 80 concentration 6%, 5%, 4% and variation of Span 80 concentration 4%,5%, 6% as an emulgator. Then a physical evaluation of the preparation wascarried out which included organoleptic tests, pH tests, homogeneity tests,emulsion type tests, viscosity tests, spreadability tests and irritation tests. Theresults of the study showed that the formula 1 emulgel was bone white whileformulas 2 and 3 were white, the pH of the preparation ranged from 4.83-5.57,the preparation was homogeneous with an O/A emulsion type, the viscosity valueof the preparation ranged from 126.67-290 cPa. s, the dispersion value rangedfrom 5.20-6.30 and the preparation was not irritating.
{"title":"THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS","authors":"Nirwati Rusli, Muhammad Azdar Setiawan, Nuraini Hikmawati","doi":"10.31603/pharmacy.v1i1.6093","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6093","url":null,"abstract":"Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic,antipireic, and antiplatelet. Aacetosal undegoes cross-first metabolisism (first passeffect) causing low drug bioavailability. The smal lsolubility of acetosal will affectthe rate of absorption which later affect the intensity of treatment, so transdermaldelivery in emulgel dosage forms can be one of. In this study an experimentalmethod was used by formulating an acetosal transdermal emulgel preparation, asa gel base HPMC was used at a concentration of 4%, 4.5%, 5% also variation oftween 80 concentration 6%, 5%, 4% and variation of Span 80 concentration 4%,5%, 6% as an emulgator. Then a physical evaluation of the preparation wascarried out which included organoleptic tests, pH tests, homogeneity tests,emulsion type tests, viscosity tests, spreadability tests and irritation tests. Theresults of the study showed that the formula 1 emulgel was bone white whileformulas 2 and 3 were white, the pH of the preparation ranged from 4.83-5.57,the preparation was homogeneous with an O/A emulsion type, the viscosity valueof the preparation ranged from 126.67-290 cPa. s, the dispersion value rangedfrom 5.20-6.30 and the preparation was not irritating.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41346635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.31603/pharmacy.v1i1.6091
Lukky Jayadi, Sandry Kesuma
One of the ways to prevent the spread of disease is to clean your hands using a hand sanitizer. Hand sanitizers are currently sterile hand sanitizers, usually as an alternative to washing the skin surface with a cleanser and air. Washing hands and skin with hand sanitizer is an action to maintain hand and skin hygiene to avoid infection that causes microbes, for example Escherichia coli microorganisms. The purpose behind this examination is make liquid hand sanitizer preparations with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts that can kill Escherichia coli bacteria. In this study, the pH of the preparation was measured, the pH was 5 and for determining the specific gravity, the specific gravity was 0.9736 g/ml. The test is carried out using the percentage kill method at two contact times, namely 30 and 60 seconds. The percentage kill results for liquid hand sanitizer with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts at the two contact times, with a percentage kill value of 99.9%. There is an impact using hand sanitizer with alcohol as an active ingredient with active alcohol ingredients with the addition of lime extract (Citrus aurantifolia) and aloe vera (Aloe vera) on pH, specific gravity and germicidal power.
{"title":"ACTIVITY TEST OF A LIQUID HAND SANITIZER WITH LIME EXTRACT (CITRUS AURANTIFOLIA) AND ALOE VERA (ALOE VERA) AGAINST ESCHERICHIA COLI BACTERIA","authors":"Lukky Jayadi, Sandry Kesuma","doi":"10.31603/pharmacy.v1i1.6091","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6091","url":null,"abstract":"One of the ways to prevent the spread of disease is to clean your hands using a hand sanitizer. Hand sanitizers are currently sterile hand sanitizers, usually as an alternative to washing the skin surface with a cleanser and air. Washing hands and skin with hand sanitizer is an action to maintain hand and skin hygiene to avoid infection that causes microbes, for example Escherichia coli microorganisms. The purpose behind this examination is make liquid hand sanitizer preparations with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts that can kill Escherichia coli bacteria. In this study, the pH of the preparation was measured, the pH was 5 and for determining the specific gravity, the specific gravity was 0.9736 g/ml. The test is carried out using the percentage kill method at two contact times, namely 30 and 60 seconds. The percentage kill results for liquid hand sanitizer with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts at the two contact times, with a percentage kill value of 99.9%. There is an impact using hand sanitizer with alcohol as an active ingredient with active alcohol ingredients with the addition of lime extract (Citrus aurantifolia) and aloe vera (Aloe vera) on pH, specific gravity and germicidal power.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47884085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-04DOI: 10.31603/pharmacy.v1i1.6081
Lilis Tuslinah, Firman Gustaman, Desi Silviani, Mira Rohimah
Anthocyanins are unstable compounds mainly due to the influence of pH and temperature, including those sourced from the Honje Laka fruit (Etlingera elatior (Jack) R.M.Sm), to increase its stability, copigmentation method is used. In this study, the stability of anthocyanins was compared after being copigmented with tatric acid and gallic acid through the value of % color retention of anthocyanins using the UV-VIS Spectrophotometry method. Based on the test results, copigmentation with tartaric acid ratio 1: 75 mmol and gallic acid 1: 100 nmol is the optimal ratio to stabilize anthocyanins at pH 2 at 300C. Optimal conditions of copigmentation with tartaric acid and gallic acid did not give a significant difference at pH 2 temperature 300C
{"title":"COMPARISON OF ANTHOCYANIN STABILITY OF ETHANOL EXTRACT Etlingera elatior (Jack) R.M. Sm. WITH COOPIGMENTATION OF TARTRIC ACID AND GALIC ACID","authors":"Lilis Tuslinah, Firman Gustaman, Desi Silviani, Mira Rohimah","doi":"10.31603/pharmacy.v1i1.6081","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6081","url":null,"abstract":"Anthocyanins are unstable compounds mainly due to the influence of pH and temperature, including those sourced from the Honje Laka fruit (Etlingera elatior (Jack) R.M.Sm), to increase its stability, copigmentation method is used. In this study, the stability of anthocyanins was compared after being copigmented with tatric acid and gallic acid through the value of % color retention of anthocyanins using the UV-VIS Spectrophotometry method. Based on the test results, copigmentation with tartaric acid ratio 1: 75 mmol and gallic acid 1: 100 nmol is the optimal ratio to stabilize anthocyanins at pH 2 at 300C. Optimal conditions of copigmentation with tartaric acid and gallic acid did not give a significant difference at pH 2 temperature 300C","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47484818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-04DOI: 10.31603/pharmacy.v1i1.6096
A. W. Yodha, Muamar Abdillah, Astrid Indalifiany, Elfahmi, Sahidin
Sappan wood extract (Caesalpinia sappan) provides better antioxidant properties than ascorbic acid. Empirically, Sappan wood is often used as traditional medicine. To support the utilization of Sappan wood, the isolation and identification of active antioxidant compounds from the methanol extract of Sappan wood had been conducted from this study. Extraction was performed with maceration and evaporation methods. The spots of active antioxidant compounds in TLC-DPPH observations were isolated using liquid vacuum chromatography to obtain two pure compounds. The results of the LC-MS/MS identification of the two compounds, respectively, exhibited peak fragmentation of molecular ions at m/z 271.09, 257.15, 167.03, 151.06, 123.12, and 104.06 at the retention time of 6.35 minutes which were translated as Alpinetine and peak fragmentation of molecular ion at m/z 287.09, 177.06, 164.05, 123.04 and 110.04 at a retention time of 5.75. minutes which were translated as 3-Deoxysappanone B. The antioxidant activity quantitatively showed that Alpinetine and 3-Deoxysappanone B were capable of scavenging DPPH radicals with IC50 values of 20.11 M and 15.28 M, respectively.
{"title":"ISOLATION AND IDENTIFICATION OF ANTIOXIDANT COMPOUNDS FROM METHANOL EXTRACT OF SAPPAN WOOD (Caesalpinia sappan)","authors":"A. W. Yodha, Muamar Abdillah, Astrid Indalifiany, Elfahmi, Sahidin","doi":"10.31603/pharmacy.v1i1.6096","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6096","url":null,"abstract":"Sappan wood extract (Caesalpinia sappan) provides better antioxidant properties than ascorbic acid. Empirically, Sappan wood is often used as traditional medicine. To support the utilization of Sappan wood, the isolation and identification of active antioxidant compounds from the methanol extract of Sappan wood had been conducted from this study. Extraction was performed with maceration and evaporation methods. The spots of active antioxidant compounds in TLC-DPPH observations were isolated using liquid vacuum chromatography to obtain two pure compounds. The results of the LC-MS/MS identification of the two compounds, respectively, exhibited peak fragmentation of molecular ions at m/z 271.09, 257.15, 167.03, 151.06, 123.12, and 104.06 at the retention time of 6.35 minutes which were translated as Alpinetine and peak fragmentation of molecular ion at m/z 287.09, 177.06, 164.05, 123.04 and 110.04 at a retention time of 5.75. minutes which were translated as 3-Deoxysappanone B. The antioxidant activity quantitatively showed that Alpinetine and 3-Deoxysappanone B were capable of scavenging DPPH radicals with IC50 values of 20.11 M and 15.28 M, respectively.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45219232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-31DOI: 10.31603/pharmacy.v7i3.6137
U. Kalsum, N. Farid, N. Inayah, M. Arman
Acne problem is the most common problem that many people fight for. Even though is not a dangerous thing, but that problem will make the sufferer feel unconfident. Acne vulgaris is an inflammatory disorder with blockage and accumulation of the Keratin materials that caused by Propionibacterium acnes bacteria. Now on, Herbal plant is the most selected one as an acne treatment because of the lack effect for the sufferer than a medical treatment. The plants are Basil (Ocimum sanctum L.) and green Lemongrass (Piper Betle L.). Both of them have a Saponin and Flavonoid as an antimicroba. Therefore, in this research will combine that two of the plants which is then formulated in to the cream form. The cream formulation made with 3 different concentration variances were 15%, 30% dan 45%. The type of the research is an in vitro of experimental research method. Where the cream formula making process done by manually and to measure that inhibition to Propionibacterium acnes bacteria. That in the concentration of 15% has an inhibition 20.02 mm, the concentration of 30% was 21.24 mm and the concentration of 45% was 25.05 mm. Inhibition zone > 20 mm categorized as very strong inhibition. So that, could be conclude the cream Basil Leaf Extract (Ocimum sanctum L.) in combination with Green Betle Leaf Extract (Piper Betle L.) had a potential and most effective concentration as an anti-acne was the third formulation (45% concentration) with an inhibition was 25.5 mm and categorized as a very strong inhibition to Propionibacterium acnes.
{"title":"POTENTIAL TEST OF GREEN BETEL (PIPER BETLE L.) LEAF EXTRACT CREAM IN COMBINATION WITH BASIL LEAF EXTRACT (OCIMUMSANCTUM L.) AS ANTI-ACNE","authors":"U. Kalsum, N. Farid, N. Inayah, M. Arman","doi":"10.31603/pharmacy.v7i3.6137","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i3.6137","url":null,"abstract":"Acne problem is the most common problem that many people fight for. Even though is not a dangerous thing, but that problem will make the sufferer feel unconfident. Acne vulgaris is an inflammatory disorder with blockage and accumulation of the Keratin materials that caused by Propionibacterium acnes bacteria. Now on, Herbal plant is the most selected one as an acne treatment because of the lack effect for the sufferer than a medical treatment. The plants are Basil (Ocimum sanctum L.) and green Lemongrass (Piper Betle L.). Both of them have a Saponin and Flavonoid as an antimicroba. Therefore, in this research will combine that two of the plants which is then formulated in to the cream form. The cream formulation made with 3 different concentration variances were 15%, 30% dan 45%. The type of the research is an in vitro of experimental research method. Where the cream formula making process done by manually and to measure that inhibition to Propionibacterium acnes bacteria. That in the concentration of 15% has an inhibition 20.02 mm, the concentration of 30% was 21.24 mm and the concentration of 45% was 25.05 mm. Inhibition zone > 20 mm categorized as very strong inhibition. So that, could be conclude the cream Basil Leaf Extract (Ocimum sanctum L.) in combination with Green Betle Leaf Extract (Piper Betle L.) had a potential and most effective concentration as an anti-acne was the third formulation (45% concentration) with an inhibition was 25.5 mm and categorized as a very strong inhibition to Propionibacterium acnes.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41981262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-04DOI: 10.31603/pharmacy.v7i2.5259
Desmariani -, Fintolin Jaya Putri, Seftika Sari, R. Dewi, Adriani Susanty, Enda Mora
Drug storage is something that must be considered because it can affect the quality of the drug. Storage conditions must adapt to the stability of each drug. This study aims to determine the level of knowledge about the storage of syrup drug preparations in patients in all public health centers in Pekanbaru. The research method is analytic observational with cross sectional design. The research sample was the people who visited all health centers in Pekanbaru city which were selected by purposive sampling technique according to the inclusion and exclusion criteria and obtained a sample of 160 respondents. The instrument is a knowledge questionnaire that has been tested for validation and reliability. The knowledge questionnaire contained 14 valid questions (r=0.818). Presentation of data with bar charts and narrative text. The results of the study revealed that there were 66 respondents (41.25%) in the good knowledge category and 94 respondents (58.75%) in the sufficient knowledge category and none of the respondents had less knowledge in the category. From these results, it can be concluded that most people do not know well how to store syrup drugs, so it is necessary for the role of pharmacists to provide education to the public, especially regarding how to store drugs correctly
{"title":"KNOWLEDGE ABOUT STORAGE OF SYRUP DRUG ON PATIENT IN PUSKESMAS PEKANBARU CITY","authors":"Desmariani -, Fintolin Jaya Putri, Seftika Sari, R. Dewi, Adriani Susanty, Enda Mora","doi":"10.31603/pharmacy.v7i2.5259","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i2.5259","url":null,"abstract":"Drug storage is something that must be considered because it can affect the quality of the drug. Storage conditions must adapt to the stability of each drug. This study aims to determine the level of knowledge about the storage of syrup drug preparations in patients in all public health centers in Pekanbaru. The research method is analytic observational with cross sectional design. The research sample was the people who visited all health centers in Pekanbaru city which were selected by purposive sampling technique according to the inclusion and exclusion criteria and obtained a sample of 160 respondents. The instrument is a knowledge questionnaire that has been tested for validation and reliability. The knowledge questionnaire contained 14 valid questions (r=0.818). Presentation of data with bar charts and narrative text. The results of the study revealed that there were 66 respondents (41.25%) in the good knowledge category and 94 respondents (58.75%) in the sufficient knowledge category and none of the respondents had less knowledge in the category. From these results, it can be concluded that most people do not know well how to store syrup drugs, so it is necessary for the role of pharmacists to provide education to the public, especially regarding how to store drugs correctly","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49489397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-12-01DOI: 10.31603/pharmacy.v7i2.5283
Novia Misnawati Aisyiyah, K. Siregar, P. M. Kustiawan
Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the community is red betel leaf (Piper crocatum). However, scientific information related to the potential of red betel as an anti-inflammatory in Rheumatoid Arthritis is still not widely known by the public. This study was conducted to explore the potential of P. crocatum leaves to treat Rheumatoid Arthritis which can be used as references regarding Rheumatoid Arthritis therapy. This study uses a narrative review method from previous studies that were collected related to the topic which was then discussed systematically. By using keywords in the search for Piper crocatum, anti-inflammatory activity, red betel bioactivity, secondary compounds in red betel leaf, and Rheumatoid Arthritis. P. crocatum leaves contain various bioactive compounds. Flavonoids have activity as primary and secondary antioxidants. Flavonoid compounds such as brazilien, brazilin, taxifolin, procyanidin found in red betel have anti-inflammatory activity in rheumatoid arthritis. Brazilin is one of the flavonoid compounds from P. crocatum leaves that has the potential as an anti-inflammatory in rheumatoid arthritis by regulating the transcription factor nuclear factor kappa B (NF-kB) for TNF- expression against inflammation.
{"title":"REVIEW: POTENTIAL OF RED BETEL LEAVES (Piper crocatum) AS ANTI-INFLAMMATORY IN Rheumatoid Arthritis","authors":"Novia Misnawati Aisyiyah, K. Siregar, P. M. Kustiawan","doi":"10.31603/pharmacy.v7i2.5283","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i2.5283","url":null,"abstract":"Indonesia is a country with fertile soil and rich in plant species. Currently in society the use of medicinal plants as herbal treatment has increased. Elderly people often experience Rheumatoid Arthritis, which is inflammation of the synovial lining of the joints. One of the plants used by the community is red betel leaf (Piper crocatum). However, scientific information related to the potential of red betel as an anti-inflammatory in Rheumatoid Arthritis is still not widely known by the public. This study was conducted to explore the potential of P. crocatum leaves to treat Rheumatoid Arthritis which can be used as references regarding Rheumatoid Arthritis therapy. This study uses a narrative review method from previous studies that were collected related to the topic which was then discussed systematically. By using keywords in the search for Piper crocatum, anti-inflammatory activity, red betel bioactivity, secondary compounds in red betel leaf, and Rheumatoid Arthritis. P. crocatum leaves contain various bioactive compounds. Flavonoids have activity as primary and secondary antioxidants. Flavonoid compounds such as brazilien, brazilin, taxifolin, procyanidin found in red betel have anti-inflammatory activity in rheumatoid arthritis. Brazilin is one of the flavonoid compounds from P. crocatum leaves that has the potential as an anti-inflammatory in rheumatoid arthritis by regulating the transcription factor nuclear factor kappa B (NF-kB) for TNF- expression against inflammation.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45901548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-30DOI: 10.31603/pharmacy.v7i2.5084
Ilil Maidatuz Zulfa, Widya Handayani
Inappropriate use of oral antibiotics will contribute to an increase in antibiotic resistance and treatment failure. Compliance with the use of oral antibiotics is one of the things that contributes to the inappropriate use of antibiotics. This study aims to analyze the effect of information booklet reminder media on adherence to short-term antibiotic use conducted in four puskesmas in the Surabaya area. Patients aged 19-50 years who were prescribed short-term antibiotics (<7 days) were included in this study. Patients were then grouped into two groups, namely the intervention group who was given an information booklet, and the control group. Compliance with the use of antibiotics was measured based on the calculation of the remaining antibiotics on the day the antibiotics ran out. A total of 192 people were recruited in this study, 96 people were in the intervention group and 96 people were in the control group. The results of measurement of adherence and analysis showed that 80.21% of patients in the intervention group were obedient in using their antibiotics, while patients in the control group were compliant with 60.42% (p-value 0.003). Based on these results, information booklets can significantly affect patient compliance in the use of short-term oral antibiotics so that information booklets can be used as one of the educational media in increasing adherence to antibiotic use.
{"title":"THE EFFECT OF INFORMATION BOOKLET ON THE PATIENTS COMPLIANCE WITH ORAL ANTIBIOTIC COURSE IN SEVERAL COMMUNITY HEALTH SERVICE","authors":"Ilil Maidatuz Zulfa, Widya Handayani","doi":"10.31603/pharmacy.v7i2.5084","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i2.5084","url":null,"abstract":"Inappropriate use of oral antibiotics will contribute to an increase in antibiotic resistance and treatment failure. Compliance with the use of oral antibiotics is one of the things that contributes to the inappropriate use of antibiotics. This study aims to analyze the effect of information booklet reminder media on adherence to short-term antibiotic use conducted in four puskesmas in the Surabaya area. Patients aged 19-50 years who were prescribed short-term antibiotics (<7 days) were included in this study. Patients were then grouped into two groups, namely the intervention group who was given an information booklet, and the control group. Compliance with the use of antibiotics was measured based on the calculation of the remaining antibiotics on the day the antibiotics ran out. A total of 192 people were recruited in this study, 96 people were in the intervention group and 96 people were in the control group. The results of measurement of adherence and analysis showed that 80.21% of patients in the intervention group were obedient in using their antibiotics, while patients in the control group were compliant with 60.42% (p-value 0.003). Based on these results, information booklets can significantly affect patient compliance in the use of short-term oral antibiotics so that information booklets can be used as one of the educational media in increasing adherence to antibiotic use.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44953536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.31603/pharmacy.v7i2.4827
Anita Puspa Widiyana
The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted by computer programs and online servers. Substituents are added at positions 2 and 3 to the quinazoline-4(3H)-on ring, such as -H, -NO2, -OCH3, -N(CH3)2, -SO2NH2, -OH, and –OCH3. QSAR as COX-2 inhibitor analysis was performed by SPSS Ver. 21 software. Lipinski’s rule of five for determining bioavailability is performed by an online server at http://ilab.acdlabs.com. The best QSAR equation used to predict the COX-2 inhibitors from these compounds is RS-pred = 0.372 Log P + 0.014 MR + 0.979 Etot – 4.859, with n= 12, R = 0.998; SE = 0.356, F = 805.252 and sig = 0.001. Six compounds were predicted to have good oral bioavailability, such as 3-(benzylideneamino)-2-(2,4-dichlorophenyl)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-methoxybenzilidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-methoxybenzylidene)amino)quinazolin-4(3H)-one, and 2-(((2-(2,4-dichlorophenyl)-4-oxoquinazolin-3(4H)-yl)imino)methyl)- benzenesulfonamide. This research can be used as an in vitro and in vivo study for BDCQ derivatives as anticancer drugs.
{"title":"COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR","authors":"Anita Puspa Widiyana","doi":"10.31603/pharmacy.v7i2.4827","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i2.4827","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted by computer programs and online servers. Substituents are added at positions 2 and 3 to the quinazoline-4(3H)-on ring, such as -H, -NO2, -OCH3, -N(CH3)2, -SO2NH2, -OH, and –OCH3. QSAR as COX-2 inhibitor analysis was performed by SPSS Ver. 21 software. Lipinski’s rule of five for determining bioavailability is performed by an online server at http://ilab.acdlabs.com. The best QSAR equation used to predict the COX-2 inhibitors from these compounds is RS-pred = 0.372 Log P + 0.014 MR + 0.979 Etot – 4.859, with n= 12, R = 0.998; SE = 0.356, F = 805.252 and sig = 0.001. Six compounds were predicted to have good oral bioavailability, such as 3-(benzylideneamino)-2-(2,4-dichlorophenyl)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-nitrobenzylidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((2-methoxybenzilidene)amino)quinazoline-4(3H)-one, 2-(2,4-dichlorophenyl)-3-((3-methoxybenzylidene)amino)quinazolin-4(3H)-one, and 2-(((2-(2,4-dichlorophenyl)-4-oxoquinazolin-3(4H)-yl)imino)methyl)- benzenesulfonamide. This research can be used as an in vitro and in vivo study for BDCQ derivatives as anticancer drugs. \u0000 \u0000 \u0000 \u0000 \u0000 \u0000 \u0000","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44648769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-11-01DOI: 10.31603/pharmacy.v7i2.4960
Endaryanti Wulandari, Aris Widayati
The scope of drug management in Primary Health Center (PHC) includes planning/selection, procurement, storage, distribution, control of use, and documentation and reporting. During the COVID-19 pandemic, there were many changes in regulation and management in Primary Health Center. Such a situation certainly has an impact on the drug management of Primary Health Center. The purpose of this study is to evaluate drug management in Salaman 1 Primary Health Center in Magelang District, Central Java Province, during the COVID-19 pandemic in 2020. This research is an evaluative study using a descriptive design with a qualitative approach. The data was obtained by three methods, i.e., direct observation, interview, and secondary data. Direct observation was applied to observe the medicines' storage space. Interviews were conducted with five informants selected purposively according to the research's purpose. The assessments of secondary data were performed from the available and relevant data documentations. Data were analyzed by triangulation approach of the three types of data produced, namely observation data, interview data, and secondary data assessment. The results show several problems regarding drug management in Salaman 1 PHC during the COVID-19 pandemic. The drug selection is not precisely suitable for the needs, while drug procurement cannot always be arranged according to the planning. Furthermore, drug distribution is relatively impeded. Control of use found the number of expired and almost expired drugs increases. Drug storage and documentation are the two steps in the drug management cycle conducted appropriately in Salaman 1 PHC during the COVID-19 pandemic. This evaluative study concludes that the COVID-19 pandemic affected the drug management cycle in Salaman 1 PHC in Magelang District in 2020. Therefore, coordination among stakeholders must be improved to anticipate unforeseen circumstances, especially during the pandemic situation. The impacts of new policy implementations must be anticipated by testing, monitoring, and evaluating.
{"title":"EVALUATION OF DRUG MANAGEMENT IN SALAMAN 1 PRIMARY HEALTH CENTER MAGELANG DURING THE COVID 19 PANDEMIC","authors":"Endaryanti Wulandari, Aris Widayati","doi":"10.31603/pharmacy.v7i2.4960","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i2.4960","url":null,"abstract":"The scope of drug management in Primary Health Center (PHC) includes planning/selection, procurement, storage, distribution, control of use, and documentation and reporting. During the COVID-19 pandemic, there were many changes in regulation and management in Primary Health Center. Such a situation certainly has an impact on the drug management of Primary Health Center. The purpose of this study is to evaluate drug management in Salaman 1 Primary Health Center in Magelang District, Central Java Province, during the COVID-19 pandemic in 2020. This research is an evaluative study using a descriptive design with a qualitative approach. The data was obtained by three methods, i.e., direct observation, interview, and secondary data. Direct observation was applied to observe the medicines' storage space. Interviews were conducted with five informants selected purposively according to the research's purpose. The assessments of secondary data were performed from the available and relevant data documentations. Data were analyzed by triangulation approach of the three types of data produced, namely observation data, interview data, and secondary data assessment. The results show several problems regarding drug management in Salaman 1 PHC during the COVID-19 pandemic. The drug selection is not precisely suitable for the needs, while drug procurement cannot always be arranged according to the planning. Furthermore, drug distribution is relatively impeded. Control of use found the number of expired and almost expired drugs increases. Drug storage and documentation are the two steps in the drug management cycle conducted appropriately in Salaman 1 PHC during the COVID-19 pandemic. This evaluative study concludes that the COVID-19 pandemic affected the drug management cycle in Salaman 1 PHC in Magelang District in 2020. Therefore, coordination among stakeholders must be improved to anticipate unforeseen circumstances, especially during the pandemic situation. The impacts of new policy implementations must be anticipated by testing, monitoring, and evaluating.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41956811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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