Pub Date : 2022-10-31DOI: 10.31603/pharmacy.v8i3.7296
B. Wijianto, A. Nurhidayah, Sri Luliana
Onchidiid slug or Onchidium typhae is a marine animal commonly found in West Kalimantan waters. This gastropod is commonly used as medicine and cosmetic by the locals. This research aims to assure the content and quality of O. typhae methanol extract by determining its secondary metabolites and heavy metal contamination. Phytochemical screening of alkaloid, steroid/ triterpenoid, flavonoid, tannin, and saponin are done using reagent tests. Chromatography profile was completed using silica gel G60 F254 plate and hexane: ethyl acetate: methanol as mobile phase. Heavy metal contamination analysis was performed using atomic absorption spectrophotometry to determine Hg, As, Cd, and Pb content. The phytochemical screening and chromatography profile of O. typhae methanol extract confirm the presence of alkaloids and steroids. Heavy metal analysis stated Hg, As, Cd, and Pb content in O. typhae are < 0,0008; < 0,001; < 0,001; and 0,05 ppm respectively. Since heavy metal levels are below the maximum contamination limit, it qualifies as a natural product ingredient.
{"title":"STANDARDIZATION OF SECONDARY METABOLITES AND HEAVY METAL CONTAMINATION ASSAY ON ONCHIDIID SLUG (ONCHIDIUM TYPHAE) WEST KALIMANTAN WATERS","authors":"B. Wijianto, A. Nurhidayah, Sri Luliana","doi":"10.31603/pharmacy.v8i3.7296","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i3.7296","url":null,"abstract":"Onchidiid slug or Onchidium typhae is a marine animal commonly found in West Kalimantan waters. This gastropod is commonly used as medicine and cosmetic by the locals. This research aims to assure the content and quality of O. typhae methanol extract by determining its secondary metabolites and heavy metal contamination. Phytochemical screening of alkaloid, steroid/ triterpenoid, flavonoid, tannin, and saponin are done using reagent tests. Chromatography profile was completed using silica gel G60 F254 plate and hexane: ethyl acetate: methanol as mobile phase. Heavy metal contamination analysis was performed using atomic absorption spectrophotometry to determine Hg, As, Cd, and Pb content. The phytochemical screening and chromatography profile of O. typhae methanol extract confirm the presence of alkaloids and steroids. Heavy metal analysis stated Hg, As, Cd, and Pb content in O. typhae are < 0,0008; < 0,001; < 0,001; and 0,05 ppm respectively. Since heavy metal levels are below the maximum contamination limit, it qualifies as a natural product ingredient.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42690236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6660
S. Shiyan, Jessica Nathasia, Galih Pratiwi
The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.
{"title":"EVALUATION OF RESPONSE CORELLATION USING CHEMOMETRICS ANALYSIS FOR PRE-OPTIMIZATION QUERCETIN – SELF EMULSION FORMULATION","authors":"S. Shiyan, Jessica Nathasia, Galih Pratiwi","doi":"10.31603/pharmacy.v8i2.6660","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6660","url":null,"abstract":"The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42674429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6902
L. H. Nurani, I. M. Sikumbang, S. Yuliani, Citra Aryani Edityaningrum
Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known to contain compounds that may be used as wound healers. The purpose of this study was to test the spray activity of betel leaf extract (Piper betle L) in healing acute wounds in male Balb/C mice. Spray formula made with various concentrations of betel leaf extract by 3% (S1), 5% (S2) and 7% (S3). The acute wound healing activity test was 15 mice divided into 5 groups S1, S2, S3, P (positive control), and C (negative control). Interventions and observations were carried out for 14 days. The results of observational analysis by calculating the ratio of wound area then One Way Anova test and Post Hoc Tukey Cramer test. The results showed that spray of betel leaf extract with a concentration of 7% was not significantly different from P (p>0.05). The conclusion in this study is that sprays of betel leaf extract 3%, 5%, and 7% may be used as an acute wound healer, the best healing activity is shown at a concentration of 7%.
伤口被称为“无声流行病”，因为如果治疗不当，它们会产生重大影响。众所周知，槟榔叶含有可以用作伤口治疗剂的化合物。本研究的目的是测试槟榔叶提取物（Piper betle L）在雄性Balb/C小鼠急性伤口愈合中的喷雾活性。用不同浓度的槟榔叶提取物按3%（S1）、5%（S2）和7%（S3）制成的喷雾配方。急性伤口愈合活性试验将15只小鼠分为5组：S1、S2、S3、P（阳性对照）和C（阴性对照）。干预和观察进行了14天。通过计算伤口面积比、单向Anova试验和Post Hoc Tukey Cramer试验的观察分析结果。结果表明，7%浓度的槟榔叶提取物喷雾与P无显著性差异（P>0.05）。本研究的结论是，3%、5%和7%的槟榔叶提取液喷雾可作为急性伤口愈合剂，7%浓度时的愈合效果最好。
{"title":"THE EFFECT OF BETEL LEAF EXTRACT SPRAY ON HISTOPATHOLOGY OF WOUND HEALING","authors":"L. H. Nurani, I. M. Sikumbang, S. Yuliani, Citra Aryani Edityaningrum","doi":"10.31603/pharmacy.v8i2.6902","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6902","url":null,"abstract":"Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known to contain compounds that may be used as wound healers. The purpose of this study was to test the spray activity of betel leaf extract (Piper betle L) in healing acute wounds in male Balb/C mice. Spray formula made with various concentrations of betel leaf extract by 3% (S1), 5% (S2) and 7% (S3). The acute wound healing activity test was 15 mice divided into 5 groups S1, S2, S3, P (positive control), and C (negative control). Interventions and observations were carried out for 14 days. The results of observational analysis by calculating the ratio of wound area then One Way Anova test and Post Hoc Tukey Cramer test. The results showed that spray of betel leaf extract with a concentration of 7% was not significantly different from P (p>0.05). The conclusion in this study is that sprays of betel leaf extract 3%, 5%, and 7% may be used as an acute wound healer, the best healing activity is shown at a concentration of 7%.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43951289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6399
Adidiya Permadi, Iis Wahyuningsih, S. Yuliani, Ibdal Satar, Ratna Wijayatri
The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, the binders play a key role on the powder cohesion properties during the formation of tablet granules. In this study, turmeric extract tablets were formulated using 15 g of turmeric extract, 35 g of aerosil, 12.8 g of lactose, 1% magnesium stearate, 200 ml of aquadest and gelatin as a binder. To evaluate the effect of gelatin on the tablet formulation, the gelatin was then prepared in different formulation namely 0.1 g (formulation A), 0.2 g (formulation B) and 0.5 g (formulation C), respectivley. Based on the tablet properties, the turmeric tablet with formulation C met the standard requirements of friability less than 1%, the hardness in the range of 4 -8 kg and disintegration time under 15 minutes.
{"title":"EFFECT OF GELATIN AS A BINDER ON TURMERIC EXTRACT TABLET FORMULATION","authors":"Adidiya Permadi, Iis Wahyuningsih, S. Yuliani, Ibdal Satar, Ratna Wijayatri","doi":"10.31603/pharmacy.v8i2.6399","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6399","url":null,"abstract":"The main components for tablet formulations are the fillers, binders, crushers, thinners and lubricants. Among these components, the binders play a key role on the powder cohesion properties during the formation of tablet granules. In this study, turmeric extract tablets were formulated using 15 g of turmeric extract, 35 g of aerosil, 12.8 g of lactose, 1% magnesium stearate, 200 ml of aquadest and gelatin as a binder. To evaluate the effect of gelatin on the tablet formulation, the gelatin was then prepared in different formulation namely 0.1 g (formulation A), 0.2 g (formulation B) and 0.5 g (formulation C), respectivley. Based on the tablet properties, the turmeric tablet with formulation C met the standard requirements of friability less than 1%, the hardness in the range of 4 -8 kg and disintegration time under 15 minutes.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47194715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6085
Ilma Nur Khafifa, Ayu Shabrina, M. F. Rochman
Nutmeg seed oil is one of essential oil which unstable in storage. The stability of nutmeg seed oil can be improved by being formulated into an emulgel with carbopol 940. This study was to determine the physical stability and SPF value of nutmeg oil emulgel in vitro with carbopol 940 as a gel base. Nutmeg seed oil emulgel was made with 10% nutmeg seed oil concentration and variation of carbopol 940 base, namely 0.60% (FI), 0.80% (FII), and 1.0% (FIII). Nutmeg seed oil emulgel was tested for physical stability including organoleptic, homogeneity, adhesion, dispersibility, viscosity, pH, and SPF value in vitro. Evaluation of physical stability and SPF value of nutmeg oil emulgel was carried out for 30 days of storage at 30±2°C with RH 65±5%. Quantitative data from evaluation of physical stability and SPF value were analyzed by t-test dependent. All the physical parameters showed no significant changes (p > 0.05). Emulgel were white, thick, with nutmeg seed oil odor. pH were in safe range for skin (6.12-6.90). Nutmeg seed oil emulgel had pseudo plastic rheology in day 0 and it changed into pseudoplastic-tixothropic on day 30. The SPF value of nutmeg seed oil emulgel FI, FII, and FIII were above 8 and it did not showed significant change after 30 days of storage (p > 0.05). The SPF value of nutmeg seed oil emulgel were categorized as maximum protection.
{"title":"STABILITY AND SUNSCREEN ACTIVITY OF NUTMEG SEED OIL EMULGEL WITH CARBOPOL 940 VARIATION AS GEL BASE","authors":"Ilma Nur Khafifa, Ayu Shabrina, M. F. Rochman","doi":"10.31603/pharmacy.v8i2.6085","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6085","url":null,"abstract":"Nutmeg seed oil is one of essential oil which unstable in storage. The stability of nutmeg seed oil can be improved by being formulated into an emulgel with carbopol 940. This study was to determine the physical stability and SPF value of nutmeg oil emulgel in vitro with carbopol 940 as a gel base. Nutmeg seed oil emulgel was made with 10% nutmeg seed oil concentration and variation of carbopol 940 base, namely 0.60% (FI), 0.80% (FII), and 1.0% (FIII). Nutmeg seed oil emulgel was tested for physical stability including organoleptic, homogeneity, adhesion, dispersibility, viscosity, pH, and SPF value in vitro. Evaluation of physical stability and SPF value of nutmeg oil emulgel was carried out for 30 days of storage at 30±2°C with RH 65±5%. Quantitative data from evaluation of physical stability and SPF value were analyzed by t-test dependent. All the physical parameters showed no significant changes (p > 0.05). Emulgel were white, thick, with nutmeg seed oil odor. pH were in safe range for skin (6.12-6.90). Nutmeg seed oil emulgel had pseudo plastic rheology in day 0 and it changed into pseudoplastic-tixothropic on day 30. The SPF value of nutmeg seed oil emulgel FI, FII, and FIII were above 8 and it did not showed significant change after 30 days of storage (p > 0.05). The SPF value of nutmeg seed oil emulgel were categorized as maximum protection.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45107135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6864
Perdana Priya Haresmita, Missya Putri Kurnia Pradani
Jamu is still the choice of Indonesian people as an alternative to modern medicine until now. As a cultural heritage of the Indonesian, jamu is still very popular from the west to the east of Indonesia. The enthusiasm of the Indonesian in consuming jamu has encouraged many traditional medicine industries to produce jamu with many kinds of claim. Jamu "X" is claimed to help maintain body health. This research was conducted to determine the total flavonoid content in jamu "X" calculated as rutin by UV-spectrophotometric method with aluminum chloride (AlCl3) reagent. Jamu "X" is a product with new formula that is expected to be marketed soon. The determination of the maximum absorbance wavelength of rutin was carried out at a wavelength of 400-800 nm and the resulting maximum absorbance wavelength of rutin was 416.5 nm. The determination of total flavonoid calculated as rutin determined using a linear regression equation from the rutin standard. The linear regression equation was determined from a rutin standard curve series with 10; 12.5; 15; 17.5 and 20 g/ml, respectively and the linear regression equation obtained y = 0.0275x + 0.093. The results of the determination of rutin in the jamu "X" were 1.474%; 1.474% and 1.469% with an average value of 1.472%.
{"title":"DETERMINATION OF TOTAL FLAVONOID IN JAMU “X” WITH UV-VISIBLE SPECTROPHOTOMETRIC METHODS","authors":"Perdana Priya Haresmita, Missya Putri Kurnia Pradani","doi":"10.31603/pharmacy.v8i2.6864","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6864","url":null,"abstract":"Jamu is still the choice of Indonesian people as an alternative to modern medicine until now. As a cultural heritage of the Indonesian, jamu is still very popular from the west to the east of Indonesia. The enthusiasm of the Indonesian in consuming jamu has encouraged many traditional medicine industries to produce jamu with many kinds of claim. Jamu \"X\" is claimed to help maintain body health. This research was conducted to determine the total flavonoid content in jamu \"X\" calculated as rutin by UV-spectrophotometric method with aluminum chloride (AlCl3) reagent. Jamu \"X\" is a product with new formula that is expected to be marketed soon. The determination of the maximum absorbance wavelength of rutin was carried out at a wavelength of 400-800 nm and the resulting maximum absorbance wavelength of rutin was 416.5 nm. The determination of total flavonoid calculated as rutin determined using a linear regression equation from the rutin standard. The linear regression equation was determined from a rutin standard curve series with 10; 12.5; 15; 17.5 and 20 g/ml, respectively and the linear regression equation obtained y = 0.0275x + 0.093. The results of the determination of rutin in the jamu \"X\" were 1.474%; 1.474% and 1.469% with an average value of 1.472%.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42092123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.6441
Arief Kusuma Wardani
Important for an emergency is to find the most potential Hesperidin, Kaempferol-3,4'-di-O-methyl ether (Ermanin); Myricetin-3-glucoside, Peonidine 3-(4’-arabinosylglucoside); Quercetin 3-(2G-rhamnosylrutinoside); and Rhamnetin 3-mannosyl-(1–2)-alloside as a lead compound from guava to develop new drugs from flavonoid analogue. Docking method through iGEMDOCK software was used to design a new lead compound candidate from several flavonoid and study its interaction with of 3CLpro (PDB ID: 7DPU). The docking method were carried out using the iGEMDOCK software version v2.1, also in the chimera-1.13.1 program is used to know the interaction profile. Druglike properties were calculated using Lipinski’s rule of five as calculated using SWISSADME prediction. Toxicity prediction herein used ADMETSAR webserver (http://lmmd.ecust.edu.cn:8000/predict/). Less toxic and showing greater affinity with a docking score stronger was found in Quercetin, is apart from good pharmacokinetic profile
{"title":"SOME NATURAL FLAVONOIDS FROM GUAVA (PSIDIUM GUAJAVA L.) AGAINST SARS COV-2, INSILICO PREDICTION AND DRUGS EVALUATION","authors":"Arief Kusuma Wardani","doi":"10.31603/pharmacy.v8i2.6441","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.6441","url":null,"abstract":"Important for an emergency is to find the most potential Hesperidin, Kaempferol-3,4'-di-O-methyl ether (Ermanin); Myricetin-3-glucoside, Peonidine 3-(4’-arabinosylglucoside); Quercetin 3-(2G-rhamnosylrutinoside); and Rhamnetin 3-mannosyl-(1–2)-alloside as a lead compound from guava to develop new drugs from flavonoid analogue. Docking method through iGEMDOCK software was used to design a new lead compound candidate from several flavonoid and study its interaction with of 3CLpro (PDB ID: 7DPU). The docking method were carried out using the iGEMDOCK software version v2.1, also in the chimera-1.13.1 program is used to know the interaction profile. Druglike properties were calculated using Lipinski’s rule of five as calculated using SWISSADME prediction. Toxicity prediction herein used ADMETSAR webserver (http://lmmd.ecust.edu.cn:8000/predict/). Less toxic and showing greater affinity with a docking score stronger was found in Quercetin, is apart from good pharmacokinetic profile","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43865362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-30DOI: 10.31603/pharmacy.v8i2.4668
Anggita Nur Fauzana, I. Hapsari, Irsalina Nurul Putri, Githa Fungie Galistiani
Background: Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Pathogenesis of Acne vulgaris is estimated to be related to several triggering factors such as food by 23.2%, stress by 26.4%, hormones by 32.7% and use of cosmetics by 47.3%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. In the content of powder that causes acne vulgaris because there are comedogenic ingredients such as lanolin. Methods: This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. Results: The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). Conclusion: the level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.
{"title":"THE INFLUENCES OF KNOWLEDGE LEVEL BEHAVIOUR AND ATTITUDE IN SELECTING TYPE OF POWDER ON THE INCIDENCE OF ACNE VULGARIS IN BANYUMAS REGENCY","authors":"Anggita Nur Fauzana, I. Hapsari, Irsalina Nurul Putri, Githa Fungie Galistiani","doi":"10.31603/pharmacy.v8i2.4668","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i2.4668","url":null,"abstract":"Background: Acne vulgaris is a chronic obstructive and inflammatory skin disease. It occurs in almost all adolescents with a prevalence of 90%. Pathogenesis of Acne vulgaris is estimated to be related to several triggering factors such as food by 23.2%, stress by 26.4%, hormones by 32.7% and use of cosmetics by 47.3%. Powder is the most widely used cosmetic in the long term and one of the causes of Acne vulgaris which causes occlusion of pores on the skin surface. In the content of powder that causes acne vulgaris because there are comedogenic ingredients such as lanolin. Methods: This study was an observational study with data collection techniques using cluster sampling and sampling technique by accidental sampling. Results: The level of knowledge of women in the Banyumas Regency was dominated by the high category as many as 64 respondents (64.0%). The incidence of acne vulgaris out of 100 respondents, 67 (67.0%) of respondents had mild acne vulgaris, 22 respondents (22.0%) had moderate acne vulgaris and 1 respondent (1.0%) had severe acne vulgaris and the rest had no acne vulgaris. Chi-square analysis showed that there was a relationship between knowledge with behavior and attitude in choosing the type of powder to the incidence of acne vulgaris as evidenced by the p value of each variable, namely 0.044 and 0.028 (p <0.05). Conclusion: the level of knowledge with behavior and attitude in choosing the powder type had a significant relationship to the incidence of acne vulgaris in women in Banyumas Regency.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42025300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.31603/pharmacy.v8i1.4662
N. E. Endriastuti, M. W. Suryoputri, D. L. Ilma
Anti-epileptic drug (AED) has a narrow therapeutic index of drugs that a slight increase in dosage showed toxic effects. The therapeutic response is difficult to predict in malnutrition status because the patient with nutritional deficiency have more complicated problems likes hypoalbuminemia, macronutrient and micronutrients deficiency that affected the levels of AEDs. The nutritional deficiency could be a direct and indirect cause of ineffective AEDs therapy and also recurrent epilepsy. This study aims to describe the use of antiepileptic drugs in Indonesian children with poor nutritional status. The research design was observational studies with cross sectional random sampling to evaluate the AED doses of malnutrition status in children. All information was collected by spreading electronic forms and interviewing the parents by phone. The data were analyzed descriptively. Total of 8 malnourished children mostly included in the range of ages from >2 to 12 years (n=5; 62.50%) with means 3,9±2,7 years. The study showed valproic acid was bigger used in monotherapy (n=5; 62,50%) than polytherapy with carbamazepine or sodium phenytoin and phenobarbital. The means estimation of valproic acid monotherapy concentration in females’ group (n=2; 33,33%) showed sub-therapeutics level were Cssmin 26,09±0,57 mg/L and Cssmax 64,17±1,39 mg/L, also the means in males’ group (n=2; 33,33%) of valproic acid monotherapy were Cssmin 22.07±2,71 mg/L and Cssmax 54.27±6.66 mg/L. All of them included in good clinical outcome of free seizure > 6 months.
{"title":"THE EVALUATION OF ANTI-EPILEPTIC DRUGS DOSAGE IN MALNOURISHED CHILDREN: CASES IN INDONESIAN COMMUNITY OF EPILEPSY","authors":"N. E. Endriastuti, M. W. Suryoputri, D. L. Ilma","doi":"10.31603/pharmacy.v8i1.4662","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i1.4662","url":null,"abstract":"Anti-epileptic drug (AED) has a narrow therapeutic index of drugs that a slight increase in dosage showed toxic effects. The therapeutic response is difficult to predict in malnutrition status because the patient with nutritional deficiency have more complicated problems likes hypoalbuminemia, macronutrient and micronutrients deficiency that affected the levels of AEDs. The nutritional deficiency could be a direct and indirect cause of ineffective AEDs therapy and also recurrent epilepsy. This study aims to describe the use of antiepileptic drugs in Indonesian children with poor nutritional status. The research design was observational studies with cross sectional random sampling to evaluate the AED doses of malnutrition status in children. All information was collected by spreading electronic forms and interviewing the parents by phone. The data were analyzed descriptively. Total of 8 malnourished children mostly included in the range of ages from >2 to 12 years (n=5; 62.50%) with means 3,9±2,7 years. The study showed valproic acid was bigger used in monotherapy (n=5; 62,50%) than polytherapy with carbamazepine or sodium phenytoin and phenobarbital. The means estimation of valproic acid monotherapy concentration in females’ group (n=2; 33,33%) showed sub-therapeutics level were Cssmin 26,09±0,57 mg/L and Cssmax 64,17±1,39 mg/L, also the means in males’ group (n=2; 33,33%) of valproic acid monotherapy were Cssmin 22.07±2,71 mg/L and Cssmax 54.27±6.66 mg/L. All of them included in good clinical outcome of free seizure > 6 months.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41778678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-30DOI: 10.31603/pharmacy.v8i1.4357
M. W. Suryoputri, H. Ekowati, Ika Mustikaningtias, Nialiana Endah
The prevalence of infectious diseases in Indonesia is high, so it can increase the use of antibiotics. The use of antibiotics which is around 40-60%. Inaddition to relatively long antibiotic therapy regimen, the lack of public knowledge in the rational use of antibiotics can cause patients to be less the risk of occurrence of antibiotic resistance, this study aims to determine the level of knowledge of PKK Cadres and to determine the level of community knowledge after providing PKK Cadres education with pharmacist assitance on antibiotic management. PKK cadres are the driving force behind village communities to carry out local health programs. The research method is a comparative descriptive with a cross sectional approach using an instrument in the form of a questionnaire and it is carried out before and after the implementation of pharmacist education. Collecting data by purposive sampling. Knowledge data of pretest and posttest were analyzed bivariately. The results of the evaluation of the education process indicated that there was an increase in the knowledge of PKK Caders. The results of pre-test dan post-test average showed increased of knowledge among PKK cadres from 69.28 to 85. The results of Wilcoxon test showed a significant difference in the PKK cadres level knowledge from the pre-test and post-test data of antibiotic management after receiving education from the pharmacist (p<0.005). Providing education on antibiotic management to PKK cadres by pharmacists has increased PKK cadres’ knowledge of antibiotic management. It is hoped that PKK cadres can disseminate this knowledge to the wider community to preventing antibiotic resistance.
{"title":"IMPROVING PKK CADRES LEVEL OF KNOWLEDGE OF ANTIBIOTIC MANAGEMENT THROUGH PHARMACISTS-DELIVERED EDUCATION INTERVENTION IN BOJONGSARI, BANYUMAS","authors":"M. W. Suryoputri, H. Ekowati, Ika Mustikaningtias, Nialiana Endah","doi":"10.31603/pharmacy.v8i1.4357","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i1.4357","url":null,"abstract":"The prevalence of infectious diseases in Indonesia is high, so it can increase the use of antibiotics. The use of antibiotics which is around 40-60%. Inaddition to relatively long antibiotic therapy regimen, the lack of public knowledge in the rational use of antibiotics can cause patients to be less the risk of occurrence of antibiotic resistance, this study aims to determine the level of knowledge of PKK Cadres and to determine the level of community knowledge after providing PKK Cadres education with pharmacist assitance on antibiotic management. PKK cadres are the driving force behind village communities to carry out local health programs. The research method is a comparative descriptive with a cross sectional approach using an instrument in the form of a questionnaire and it is carried out before and after the implementation of pharmacist education. Collecting data by purposive sampling. Knowledge data of pretest and posttest were analyzed bivariately. The results of the evaluation of the education process indicated that there was an increase in the knowledge of PKK Caders. The results of pre-test dan post-test average showed increased of knowledge among PKK cadres from 69.28 to 85. The results of Wilcoxon test showed a significant difference in the PKK cadres level knowledge from the pre-test and post-test data of antibiotic management after receiving education from the pharmacist (p<0.005). Providing education on antibiotic management to PKK cadres by pharmacists has increased PKK cadres’ knowledge of antibiotic management. It is hoped that PKK cadres can disseminate this knowledge to the wider community to preventing antibiotic resistance.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49255532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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