Pub Date : 2023-03-31DOI: 10.31603/pharmacy.v9i1.6924
Seftika Sari, Rickha Octavia, Novelia Sukista
Giving the Sinovac vaccine for Covid 19 can cause several side effects. The existence of side effects that occur, of course, affect their lives, including a decrease in activity, productivity and quality of life. This study aims to determine the HRQoL score in the community after the Sinovac vaccine in Tampan District and Marpoyan District, Pekanbaru City. The research method is analytic observational with a cross-sectional design. The research sample was people who received the first vaccine recorded at the Puskesmas in Tampan District and Marpoyan District, Pekanbaru City, which was selected by purposive sampling technique according to inclusion and exclusion criteria and obtained a sample of 100 respondents. The instrument is a questionnaire EQ5D5L and EQ-VAS. The study results showed that there was little problem with the dimensions of pain (37%) and usual activities (14%), with a score of 0,944 (EQ5D5L) and 0,975 (EQ-VAS). In conclusion, the HRQoL scores on EQ5D5L and EQ-VAS are close to 1, which means close to perfect. This research is expected to be a reference for stakeholders in selecting preventive therapy for Covid 19 and can be used as initial data for cost-utility analysis research.
{"title":"HEALTH-RELATED QUALITY OF LIFE POST-SINOVAC VACCINE IN COMMUNITIES IN TAMPAN DISTRICT AND MARPOYAN DISTRICT, PEKANBARU CITY","authors":"Seftika Sari, Rickha Octavia, Novelia Sukista","doi":"10.31603/pharmacy.v9i1.6924","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.6924","url":null,"abstract":"Giving the Sinovac vaccine for Covid 19 can cause several side effects. The existence of side effects that occur, of course, affect their lives, including a decrease in activity, productivity and quality of life. This study aims to determine the HRQoL score in the community after the Sinovac vaccine in Tampan District and Marpoyan District, Pekanbaru City. The research method is analytic observational with a cross-sectional design. The research sample was people who received the first vaccine recorded at the Puskesmas in Tampan District and Marpoyan District, Pekanbaru City, which was selected by purposive sampling technique according to inclusion and exclusion criteria and obtained a sample of 100 respondents. The instrument is a questionnaire EQ5D5L and EQ-VAS. The study results showed that there was little problem with the dimensions of pain (37%) and usual activities (14%), with a score of 0,944 (EQ5D5L) and 0,975 (EQ-VAS). In conclusion, the HRQoL scores on EQ5D5L and EQ-VAS are close to 1, which means close to perfect. This research is expected to be a reference for stakeholders in selecting preventive therapy for Covid 19 and can be used as initial data for cost-utility analysis research.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47436990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.31603/pharmacy.v9i1.8207
I. S. Lingga, Sarhana Sarhana Rassya Aulyah Said, Dina Ayomi, Rusnaeni Rusnaeni, E. Gunawan, Nur Fadilah Bakri, E. Sianturi
Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted. Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.
{"title":"FACTORS ASSOCIATED WITH RATIONALITY OF ANTIMALARIA PRESCRIPTION IN PAPUA PROVINCE","authors":"I. S. Lingga, Sarhana Sarhana Rassya Aulyah Said, Dina Ayomi, Rusnaeni Rusnaeni, E. Gunawan, Nur Fadilah Bakri, E. Sianturi","doi":"10.31603/pharmacy.v9i1.8207","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.8207","url":null,"abstract":"Malaria remains a leading cause of death in Papua and combination of Dihydroartemisin -Piperaquine (DHP) and Primaquine (PQ) is recommended treatment to replace chloroquine out since chloroquine resistance present. Moreover, awareness of rational prescription and adherence may be the first priority in malaria treatment in preventing death and resistance in Papua. This study aimed to assess the rationality of antimalaria prescription in the public and private sectors of Papua Province. This cross-sectional study was conducted. Overall, 571 prescriptions were included in this study and more than half of prescription was rational (65%). This study was predominantly female (65%). More than half was diagnosed by P. falciparum (54%), using referred using the public hospital for treatment (54%) and self-identified as Papuan (50%). According to type of malaria, incorrect of prescription DHP and PQ were 20% and 18%, respectively. The multiple logistic regression model showed that female was significantly associated to receive irrational of prescriptions than males (OR = 1.549; 95% CI =1.004-2.389). Participants who had P. falciparum increased the likelihood of irrational of prescriptions (OR= 1.641; 95% CI =1.144-2.355). There is a need to have a continuum strategy to improve access and utilization of malaria case management in both public and private health facilities. Inequality gender based on prescribers needs to be investigated. Competence improvement among healthcare providers needs to be a priority to prevent antimalarial resistance.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43288651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-25DOI: 10.31603/pharmacy.v9i1.8257
A. T. Annisa, N. M. Yasin, S. A. Kristina
The electronic prescribing system has a good role in health services with the powerful features that this system has, when compared to manual prescribing. This systematic review aims to determine the role of the electronic prescribing system in health services. The literature search was conducted from 21 November 2022 using PubMed, ProQuest, Google Scholar, ScienceDirect, Scopus, and Sage PUB as literature search area databases. A literature search strategy using BOOLEAN Operator to help specify the search terms. Literature search based on inclusion criteria. After eliminating duplication, title, abstract and full text, 8 articles were obtained for analysis. The electronic prescribing system has a good role in health services, including reducing medication errors, improving the quality of communication and information both between staff and staff and patients, shortening service time, having an alert system that is able to detect allergies, drug interactions, and adverse drug reactions. desired, time and cost efficiency, effectiveness in terms of patient safety, providing satisfaction for users because with these qualified features they can help in terms of service when compared to manual prescriptions. Further research should be conduct to review the role of Clinical Decision Support System and the electronic Health Record in healthcare due to its limitation.
{"title":"THE ROLE OF THE E-PRESCRIBING SYSTEM IN HEALTHCARE: A SYSTEMATIC REVIEW","authors":"A. T. Annisa, N. M. Yasin, S. A. Kristina","doi":"10.31603/pharmacy.v9i1.8257","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.8257","url":null,"abstract":"The electronic prescribing system has a good role in health services with the powerful features that this system has, when compared to manual prescribing. This systematic review aims to determine the role of the electronic prescribing system in health services. The literature search was conducted from 21 November 2022 using PubMed, ProQuest, Google Scholar, ScienceDirect, Scopus, and Sage PUB as literature search area databases. A literature search strategy using BOOLEAN Operator to help specify the search terms. Literature search based on inclusion criteria. After eliminating duplication, title, abstract and full text, 8 articles were obtained for analysis. The electronic prescribing system has a good role in health services, including reducing medication errors, improving the quality of communication and information both between staff and staff and patients, shortening service time, having an alert system that is able to detect allergies, drug interactions, and adverse drug reactions. desired, time and cost efficiency, effectiveness in terms of patient safety, providing satisfaction for users because with these qualified features they can help in terms of service when compared to manual prescriptions. Further research should be conduct to review the role of Clinical Decision Support System and the electronic Health Record in healthcare due to its limitation.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44246857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-21DOI: 10.31603/pharmacy.v9i1.6925
Faridah Baroroh, Ridhaul Maghfiroh
The province that ranks fourth with the highest incidence of hypertension in Indonesia is the Special Region of Yogyakarta (DIY). Hypertension therapy is carried out in a not short period, so it becomes an economic burden for people with hypertension and the government. This study aims to determine the relationship between the length of hospitalization and direct medical costs—an analytical observational research method with retrospective data collection and data from class III inpatient hypertensive medical records. The calculation of costs is viewed from a payer's perspective—descriptive and analytical data analysis to determine the relationship between the length of hospitalization and direct medical costs. The study's results of 41 patients met the criteria; 53.65% were women aged 22-59 years (53.65%). The most widely used antihypertensive drug was the combination of amlodipine + candesartan (26.82%). The average direct medical costs for hypertensive patients were IDR 7,039,515. The highest direct medical cost component is the cost of other drugs and medical equipment. The component of direct medical costs is the lowest cost of antihypertensive drugs. The average length of hospitalization for hypertensive patients is 6.14 days. There was a significant relationship (p=0.000) between the length of hospitalization and direct medical costs. The conclusion of this study is a significant relationship (p = 0.000) between the length of hospitalization and direct medical costs
{"title":"DIRECT MEDICAL COST AND LENGTH OF STAY OF HYPERTENSION PATIENTS AT PRIVATE HOSPITAL IN YOGYAKARTA","authors":"Faridah Baroroh, Ridhaul Maghfiroh","doi":"10.31603/pharmacy.v9i1.6925","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.6925","url":null,"abstract":"The province that ranks fourth with the highest incidence of hypertension in Indonesia is the Special Region of Yogyakarta (DIY). Hypertension therapy is carried out in a not short period, so it becomes an economic burden for people with hypertension and the government. This study aims to determine the relationship between the length of hospitalization and direct medical costs—an analytical observational research method with retrospective data collection and data from class III inpatient hypertensive medical records. The calculation of costs is viewed from a payer's perspective—descriptive and analytical data analysis to determine the relationship between the length of hospitalization and direct medical costs. The study's results of 41 patients met the criteria; 53.65% were women aged 22-59 years (53.65%). The most widely used antihypertensive drug was the combination of amlodipine + candesartan (26.82%). The average direct medical costs for hypertensive patients were IDR 7,039,515. The highest direct medical cost component is the cost of other drugs and medical equipment. The component of direct medical costs is the lowest cost of antihypertensive drugs. The average length of hospitalization for hypertensive patients is 6.14 days. There was a significant relationship (p=0.000) between the length of hospitalization and direct medical costs. The conclusion of this study is a significant relationship (p = 0.000) between the length of hospitalization and direct medical costs","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43363679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.31603/pharmacy.v9i1.7915
Aan Kunaedi, I. Indawati, N. Karlina, Zakie Fadhillah, Citra Dhea Cantika, Ade Ayu Khulfiah
Ethanol extract from the leaves of Morus alba, an herb, has been widely used for medicine, including commercial formulations. This study aims to compare the characteristics of NADES extract using the MAE method and the maceration method. Mulberry leaf simplicia (Morus alba. L) ethanol extract was made with various ethanol concentrations of 50%, 60%, 70%, 80%, and 90%, and NADES (Natural Deep Eutectic Solvents) extract with a solvent ratio of 1:20 and 1: 30 on the MAE (Microwave Assisted Extraction) method with a time of 5 and 10 minutes. Measurement of total flavonoid content and total phenolic content was carried out by UV-vis spectrophotometry with quercetin and gallic acid as reference standards. The results showed that the ethanol extract with ethanol concentrations of 50%, 60%, 70%, 80%, and 90% had an average total flavonoid content; and total phenolic: 0.73%, 0.9%, 1.32%, 1.18%, 0.77%; total phenolic 96.789 mg/g, 71.262 mg/g, 126.465 mg/g, 116.643 mg/g, 93.366 mg/g. NADES extract with a solvent ratio of 1:20 at MAE 5" and 10" minutes obtained flavonoid levels of 0.36%, 0.4%, and total phenolic levels of 36.099 mg/g; 75.621 mg/g. While a ratio of 1:30 with an MAE time of 5" and 10" minutes, the flavonoid content was 0.44%; 0.48%, and the total phenolic content of 61.884 mg/g; 121.237 mg/g. Results of water-soluble essence of ethanol extract; NADES is 26%–31%; 21–24%. Result of ethanol soluble extract content of ethanol extract; NADES is in the range of 36%–42%; 85%–86%. Result of the specific gravity of ethanol extract; NADES is in the range of 0.82 g/mL–0.95 g/mL; 1.08 g/mL–1.18 g/mL. The ethanol extract pH test results were; NADES in the range 6.90–7.01; 7.59–7.89.
{"title":"STUDY ON THE OPTIMIZATION OF MULBERRY LEAF EXTRACT BY MACERATING ETHANOL AND MICROWAVE ASSISTED EXTRACTION METHOD (MAE) WITH NATURAL DEEP EUTECTIC SOLVENTS (NADES)","authors":"Aan Kunaedi, I. Indawati, N. Karlina, Zakie Fadhillah, Citra Dhea Cantika, Ade Ayu Khulfiah","doi":"10.31603/pharmacy.v9i1.7915","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.7915","url":null,"abstract":"Ethanol extract from the leaves of Morus alba, an herb, has been widely used for medicine, including commercial formulations. This study aims to compare the characteristics of NADES extract using the MAE method and the maceration method. Mulberry leaf simplicia (Morus alba. L) ethanol extract was made with various ethanol concentrations of 50%, 60%, 70%, 80%, and 90%, and NADES (Natural Deep Eutectic Solvents) extract with a solvent ratio of 1:20 and 1: 30 on the MAE (Microwave Assisted Extraction) method with a time of 5 and 10 minutes. Measurement of total flavonoid content and total phenolic content was carried out by UV-vis spectrophotometry with quercetin and gallic acid as reference standards. The results showed that the ethanol extract with ethanol concentrations of 50%, 60%, 70%, 80%, and 90% had an average total flavonoid content; and total phenolic: 0.73%, 0.9%, 1.32%, 1.18%, 0.77%; total phenolic 96.789 mg/g, 71.262 mg/g, 126.465 mg/g, 116.643 mg/g, 93.366 mg/g. NADES extract with a solvent ratio of 1:20 at MAE 5\" and 10\" minutes obtained flavonoid levels of 0.36%, 0.4%, and total phenolic levels of 36.099 mg/g; 75.621 mg/g. While a ratio of 1:30 with an MAE time of 5\" and 10\" minutes, the flavonoid content was 0.44%; 0.48%, and the total phenolic content of 61.884 mg/g; 121.237 mg/g. Results of water-soluble essence of ethanol extract; NADES is 26%–31%; 21–24%. Result of ethanol soluble extract content of ethanol extract; NADES is in the range of 36%–42%; 85%–86%. Result of the specific gravity of ethanol extract; NADES is in the range of 0.82 g/mL–0.95 g/mL; 1.08 g/mL–1.18 g/mL. The ethanol extract pH test results were; NADES in the range 6.90–7.01; 7.59–7.89.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48456857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-31DOI: 10.31603/pharmacy.v9i1.7916
R. Susilo, T. -, Nur Rahmi Hidayati, Deani Asmarandani, Daffa Fadhilah
Late antiviral treatment can potentially cause the Covid-19 virus to replicate very quickly, so it is necessary to understand antiviral drugs and optimize treatment for Covid-19 patients. The study aimed to determine the correlation between the severity, speed of administration of antivirals, and the recovery time of Covid-19 patients. This type of research is an observational study with retrospective data collection on 94 Covid-19 medical records at “X” Hospital Cirebon from 316 populations in June-July 2021 according to inclusion criteria. The data analysis used was univariate and bivariate using Spearman's Rho. The 55–59-year age group (28.7%) was the most infected with Covid-19. There are more males than females (52.1% vs 47.9%). Favipiravir therapy (43.6%) was given the most. Moderate severity (74.5%) had the highest proportion. The speed of administration of antivirals was most initiated at 5-8 days (42.6%) after the onset of symptoms. The maximum recovery time for Covid-19 patients is 13-18 days (58.5%). A strong positive correlation between the speed of giving antivirals to the recovery time of Covid-19 patients (sig. 0.000) and the correlation coefficient of 0.659. Does not show a correlation between the severity of recovery time (sig. 0.113) and speed of antiviral administration to the severity of Covid-19 patients (sig. 0.297). There is a correlation between the early antiviral treatment and the recovery time of Covid-19 patients; the earlier antiviral therapy is given, the faster it will heal.
{"title":"STUDY OF THE SEVERITY AND EARLY ANTIVIRAL TREATMENT FOR THE DURATION OF THE RECOVERY COVID-19 PATIENTS","authors":"R. Susilo, T. -, Nur Rahmi Hidayati, Deani Asmarandani, Daffa Fadhilah","doi":"10.31603/pharmacy.v9i1.7916","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.7916","url":null,"abstract":"Late antiviral treatment can potentially cause the Covid-19 virus to replicate very quickly, so it is necessary to understand antiviral drugs and optimize treatment for Covid-19 patients. The study aimed to determine the correlation between the severity, speed of administration of antivirals, and the recovery time of Covid-19 patients. This type of research is an observational study with retrospective data collection on 94 Covid-19 medical records at “X” Hospital Cirebon from 316 populations in June-July 2021 according to inclusion criteria. The data analysis used was univariate and bivariate using Spearman's Rho. The 55–59-year age group (28.7%) was the most infected with Covid-19. There are more males than females (52.1% vs 47.9%). Favipiravir therapy (43.6%) was given the most. Moderate severity (74.5%) had the highest proportion. The speed of administration of antivirals was most initiated at 5-8 days (42.6%) after the onset of symptoms. The maximum recovery time for Covid-19 patients is 13-18 days (58.5%). A strong positive correlation between the speed of giving antivirals to the recovery time of Covid-19 patients (sig. 0.000) and the correlation coefficient of 0.659. Does not show a correlation between the severity of recovery time (sig. 0.113) and speed of antiviral administration to the severity of Covid-19 patients (sig. 0.297). There is a correlation between the early antiviral treatment and the recovery time of Covid-19 patients; the earlier antiviral therapy is given, the faster it will heal.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49571028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-29DOI: 10.31603/pharmacy.v9i1.7912
N. Karlina, Aan Kunaedi, Didin Ahidin, Uzlifatul Jannah, Yasmin Zahiyah
African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.
{"title":"ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD","authors":"N. Karlina, Aan Kunaedi, Didin Ahidin, Uzlifatul Jannah, Yasmin Zahiyah","doi":"10.31603/pharmacy.v9i1.7912","DOIUrl":"https://doi.org/10.31603/pharmacy.v9i1.7912","url":null,"abstract":"African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49631845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.31603/pharmacy.v8i3.7909
D. Firmansyah, Didin Ahidin, Sulistiorini Indriaty, S. Nurhasanah, Nahdia Fajri Mahmudah, T. Sumarni
Brotowali (Tinospora cordifolia) plants are usually used for various kinds of treatment it is often used as a febrifuge, brotowali stems are proven to contain flavonoid compounds that have benefits in the treatment of various diseases, one of which is analgesic. This purpose is to determine the effectiveness of analgesics on male Swiss mice induced by acetic acid from the ethanol extract of brotowali stem (EETC) doses of 100 mg/Kg BW, 200 mg/Kg BW, and 400 mg/Kg BW. Brotowali stem extraction using maceration method with 70% ethanol solvent. EETC was tested by phytochemical screening and TLC to determine the content of active compounds. The test animals used Swiss male mice, the treatment group was divided into 5, negative control group, positive control, and the dose groups were 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Testing is done by the writhing test method. Induction of pain stimuli using acetic acid, the number of mice writhing every 10 minutes for 1 hour, and the percentage of analgesic power. Research shows the yield of EETC is 16.35%. The percentage of analgetic power of dose I was 39%, dose II was 47% and dose III was 56% less than the percentage of analgesic power of methampyrone dose of 65 mg/KgBB which was 64%. Conclusion EETC doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW have analgesic activity equivalent to methampyrone at a dose of 65 mg/kg BW, with the largest percentage of analgesic protection at a dose of 400 mg/Kg BW of 56%.
{"title":"ANALGETIC POWER OF ETHANOL EXTRACT BROTOWALI (TINOSPORA CORDIFOLIA) IN SWISS MICE","authors":"D. Firmansyah, Didin Ahidin, Sulistiorini Indriaty, S. Nurhasanah, Nahdia Fajri Mahmudah, T. Sumarni","doi":"10.31603/pharmacy.v8i3.7909","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i3.7909","url":null,"abstract":"Brotowali (Tinospora cordifolia) plants are usually used for various kinds of treatment it is often used as a febrifuge, brotowali stems are proven to contain flavonoid compounds that have benefits in the treatment of various diseases, one of which is analgesic. This purpose is to determine the effectiveness of analgesics on male Swiss mice induced by acetic acid from the ethanol extract of brotowali stem (EETC) doses of 100 mg/Kg BW, 200 mg/Kg BW, and 400 mg/Kg BW. Brotowali stem extraction using maceration method with 70% ethanol solvent. EETC was tested by phytochemical screening and TLC to determine the content of active compounds. The test animals used Swiss male mice, the treatment group was divided into 5, negative control group, positive control, and the dose groups were 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Testing is done by the writhing test method. Induction of pain stimuli using acetic acid, the number of mice writhing every 10 minutes for 1 hour, and the percentage of analgesic power. Research shows the yield of EETC is 16.35%. The percentage of analgetic power of dose I was 39%, dose II was 47% and dose III was 56% less than the percentage of analgesic power of methampyrone dose of 65 mg/KgBB which was 64%. Conclusion EETC doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW have analgesic activity equivalent to methampyrone at a dose of 65 mg/kg BW, with the largest percentage of analgesic protection at a dose of 400 mg/Kg BW of 56%.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49149330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-30DOI: 10.31603/pharmacy.v8i3.3702
D. Anggraini, Listiya Pramesti Mirantana
Liver is a part of body that is used as a toxin neutralizer as well as a target for increasing free radicals. In counteracting free radicals, body needs antioxidants in one of the plant secondary metabolites, namely anthocyanins. Anthocyanins are organic compounds from the water-soluble flavonoid family that give red, blue, and violet colors. Fermentation can increase anthocyanin levels in kidney beans. This study aimed to determine the presence of anthocyanins in kidney bean (Phaseolus vulgaris L.) tempeh which can be used as a hepatoprotective agent and to determine the anthocyanin levels in kidney bean (Phaseolus vulgaris L.) tempeh. Qualitative analysis using HCl and NaOH with positive results showed the color change to solid red then to bluish green and then faded. Determination of total anthocyanin levels was carried out using UV-Vis spectrophotometric method with the pH differential principal in anthocyanin showed in mg/100gram sample at a maximum wavelength of 525.5 nm. The result was that the average anthocyanin content was 40.37mg/100gram with a variant coefficient is 0.325%.
{"title":"DETERMINATION OF ANTHOCYANIN LEVEL IN KIDNEY BEAN (Phaseolus vulgaris L.) TEMPEH AS A HEPATOPROTECTIVE AGENT","authors":"D. Anggraini, Listiya Pramesti Mirantana","doi":"10.31603/pharmacy.v8i3.3702","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i3.3702","url":null,"abstract":"Liver is a part of body that is used as a toxin neutralizer as well as a target for increasing free radicals. In counteracting free radicals, body needs antioxidants in one of the plant secondary metabolites, namely anthocyanins. Anthocyanins are organic compounds from the water-soluble flavonoid family that give red, blue, and violet colors. Fermentation can increase anthocyanin levels in kidney beans. This study aimed to determine the presence of anthocyanins in kidney bean (Phaseolus vulgaris L.) tempeh which can be used as a hepatoprotective agent and to determine the anthocyanin levels in kidney bean (Phaseolus vulgaris L.) tempeh. Qualitative analysis using HCl and NaOH with positive results showed the color change to solid red then to bluish green and then faded. Determination of total anthocyanin levels was carried out using UV-Vis spectrophotometric method with the pH differential principal in anthocyanin showed in mg/100gram sample at a maximum wavelength of 525.5 nm. The result was that the average anthocyanin content was 40.37mg/100gram with a variant coefficient is 0.325%.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42522719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-01DOI: 10.31603/pharmacy.v8i3.6268
N. Sulistyani, Zikri Almahdi, Z. –, Alfian Syarifuddin
Aloe vera leaf (Aloe vera L.) and cherry leaf (Muntingia calabura L.) contain bioactive compounds that serve as the potential antibacterial agent. The combination treatment of multiple extracts can produce a stronger effect than a single compound. This study aims to determine the synergistic combination of aloe vera leaf extract (EDLB) and cherry leaf extract (EDK) as an antibacterial agent against Staphylococcus aureus ATCC 25923. The extract was obtained by maceration using 96% ethanol. Chemical content in the extract was analyzed by tube test and thin layer chromatography (TLC). Antibacterial activity against S. aureus ATCC 25923 was measured by the checkerboard microdilution method on a 96 well microplate. The effect of the combination of extracts on antibacterial activity was based on the fractional inhibitory concentration index (FICI) value. EDLB and EDK contain flavonoids, tannins, alkaloids, and saponins. The second combination showed a synergistic effect with a FICI value of 0.5 in inhibiting the growth of S. aureus with minimal inhibitory levels in a mixture of 0.625 mg/mL EDLB and 2.5 mg/mL EDK.
{"title":"SINERGISTIC COMBINATION OF ALOE VERA AND KERSEN LEAF EXTRACTS FOR INHIBITION OF THE GROWTH OF Staphylococcus aureus 25923","authors":"N. Sulistyani, Zikri Almahdi, Z. –, Alfian Syarifuddin","doi":"10.31603/pharmacy.v8i3.6268","DOIUrl":"https://doi.org/10.31603/pharmacy.v8i3.6268","url":null,"abstract":"Aloe vera leaf (Aloe vera L.) and cherry leaf (Muntingia calabura L.) contain bioactive compounds that serve as the potential antibacterial agent. The combination treatment of multiple extracts can produce a stronger effect than a single compound. This study aims to determine the synergistic combination of aloe vera leaf extract (EDLB) and cherry leaf extract (EDK) as an antibacterial agent against Staphylococcus aureus ATCC 25923. The extract was obtained by maceration using 96% ethanol. Chemical content in the extract was analyzed by tube test and thin layer chromatography (TLC). Antibacterial activity against S. aureus ATCC 25923 was measured by the checkerboard microdilution method on a 96 well microplate. The effect of the combination of extracts on antibacterial activity was based on the fractional inhibitory concentration index (FICI) value. EDLB and EDK contain flavonoids, tannins, alkaloids, and saponins. The second combination showed a synergistic effect with a FICI value of 0.5 in inhibiting the growth of S. aureus with minimal inhibitory levels in a mixture of 0.625 mg/mL EDLB and 2.5 mg/mL EDK.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45073029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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