Pub Date : 2022-01-25DOI: 10.31603/pharmacy.v7i3.6521
M. Malaka, H. Hartina, A. Fristiohady, B. Sadarun, I. Sahidin
Sponges are marine organism that contain various chemical compound with potential pharmacological activities. This study aims to isolate and identify secondary metabolites from ethyl acetate extract of Petrosia sp. and its antioxidant properties. Extraction was performed by maceration using ethyl acetate. Isolation methods were carried out using Thin Layer Chromatography (TLC), Vacuum Liquid Chromatography (VLC), and Radial Chromatography (RC) technique. Isolated compound was identified by 1D-NMR (1H and 13C NMR) and 2D-NMR (HMQC and HMBC). Antioxidant assay was determined by its activity against ABTS radical. Isolated compound identified as an alkaloid namely 6-hydroxy-1,3,7-trimethyl-3,5-dihydro-1-Himidazo [4,5-c] piridine -2,4-dione. Antioxidant activity test showed Petrosia sp. extract was active as antioxidant with IC50 values 27.20 μg/mL against DPPH and 27.53 μg/mL against ABTS, whereas isolated compound was inactive against DPPH and ABTS with IC50 values 242.64 μg/mL. Meanwhile, Vitamin C was very active against DPPH and ABTS with IC50 21.51 μg/mL and 22.21 μg/mL, respectively.
{"title":"ISOLATION AND IDENTIFICATION OF SECONDARY METABOLITE FROM ETHYL ACETATE EXTRACT OF PETROSIA SP. AND ITS ANTIOXIDANT ACTIVITY","authors":"M. Malaka, H. Hartina, A. Fristiohady, B. Sadarun, I. Sahidin","doi":"10.31603/pharmacy.v7i3.6521","DOIUrl":"https://doi.org/10.31603/pharmacy.v7i3.6521","url":null,"abstract":"Sponges are marine organism that contain various chemical compound with potential pharmacological activities. This study aims to isolate and identify secondary metabolites from ethyl acetate extract of Petrosia sp. and its antioxidant properties. Extraction was performed by maceration using ethyl acetate. Isolation methods were carried out using Thin Layer Chromatography (TLC), Vacuum Liquid Chromatography (VLC), and Radial Chromatography (RC) technique. Isolated compound was identified by 1D-NMR (1H and 13C NMR) and 2D-NMR (HMQC and HMBC). Antioxidant assay was determined by its activity against ABTS radical. Isolated compound identified as an alkaloid namely 6-hydroxy-1,3,7-trimethyl-3,5-dihydro-1-Himidazo [4,5-c] piridine -2,4-dione. Antioxidant activity test showed Petrosia sp. extract was active as antioxidant with IC50 values 27.20 μg/mL against DPPH and 27.53 μg/mL against ABTS, whereas isolated compound was inactive against DPPH and ABTS with IC50 values 242.64 μg/mL. Meanwhile, Vitamin C was very active against DPPH and ABTS with IC50 21.51 μg/mL and 22.21 μg/mL, respectively.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43498364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-18DOI: 10.31603/pharmacy.v1i1.6104
N. Nasrudin, A. Rahman, Nurlansi, Rahmanpiu, Damhuri, B. S. Santoso, Kismawati, Jusna, Lulu Rahmatia
Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on the IC50 steeping value, then converted in the form of weight (grams) of DKJ and DS powder so that 36 combinations are obtained. The result of phytochemical analysis of DKJ and DS steeping showed the presence of flavonoids, saponins and polyphenols, except tannins only exist in the steeping of DS. The radical scavenger activity of DKJ and DS steeping showed IC50 values of 408.95 ± 0.075 µg/mL and 259.05 ± 0.092 µg/mL. The combination that showed the highest DPPH radical scavenger activity of 88.050.03% occurred in the combination of E1 with a ratio of 2IC50 DK: 1/8IC50DS (1,089: 0.128) grams. DPPH radical scavenger activity approaching 50% occurs in the combination of A2 and B1 with a ratio of 1/8IC50 DKJ: ¼IC50DS (0.068:0.256) grams and ¼IC50 DKJ: 1/8IC50DS (0.136:0.128) grams with values of (49.11 0.04) % and (52.87 0.05) % respectively.
{"title":"PHYTOCHEMICALS AND RADICAL SCAVENGER ACTIVITY OF KAYU JAWA (LANNEA COROMANDELICA) AND SALAM (SYZYGIUM POLYANTHUM) LEAF STEEPING AND THE COMBINATED RATIONAL","authors":"N. Nasrudin, A. Rahman, Nurlansi, Rahmanpiu, Damhuri, B. S. Santoso, Kismawati, Jusna, Lulu Rahmatia","doi":"10.31603/pharmacy.v1i1.6104","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6104","url":null,"abstract":"Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on the IC50 steeping value, then converted in the form of weight (grams) of DKJ and DS powder so that 36 combinations are obtained. The result of phytochemical analysis of DKJ and DS steeping showed the presence of flavonoids, saponins and polyphenols, except tannins only exist in the steeping of DS. The radical scavenger activity of DKJ and DS steeping showed IC50 values of 408.95 ± 0.075 µg/mL and 259.05 ± 0.092 µg/mL. The combination that showed the highest DPPH radical scavenger activity of 88.050.03% occurred in the combination of E1 with a ratio of 2IC50 DK: 1/8IC50DS (1,089: 0.128) grams. DPPH radical scavenger activity approaching 50% occurs in the combination of A2 and B1 with a ratio of 1/8IC50 DKJ: ¼IC50DS (0.068:0.256) grams and ¼IC50 DKJ: 1/8IC50DS (0.136:0.128) grams with values of (49.11 0.04) % and (52.87 0.05) % respectively.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45294716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-18DOI: 10.31603/pharmacy.v1i1.6095
Nurafifah Daud, Ade Ainun Insani, Eny Nurhikma
Red spinach (Amaranthus tricolor L.) contains various secondary metabolites that act as antioxidants. These activities can be used to maintain the health of facial skin due to the negative impact of free radicals in the form of cosmetic preparations of peel-off gel mask. This study aims to make a peel-off gel mask preparation from red spinach extract that meets the requirements for physical evaluation of the preparation. The extraction process was carried out by maceration method using 96% ethanol as solvent. The thick extract was then made into a peel-off gel mask preparation with variations in extract concentration of 0.5% (F1), 1% (F2), and 2% (F3). Furthermore, physical evaluation of the preparation at room temperature for 4 weeks of storage, drying time test, irritation test, preference test, and cycling test was carried out. The red spinach used has been determined as Amaranthus tricolor L. The results of phytochemical screening of the thick extract showed that the extract contained positive alkaloids, saponins and flavonoids. The results of the evaluation showed that all preparations met the physical evaluation requirements and were not irritating. The higher the concentration of the extract, the darker the color of the preparation and the higher the pH and viscosity values. The preparation was stable during storage at room temperature but decreased in pH value and dispersion after passing 6 cycles of cycling test. The results of the preference test showed 60% of respondents liked F3, which is a formula with a dark green color, a distinctive aroma of red spinach, homogeneous, pH 7.54, dispersion of 6.2 cm, the viscosity of 7200 cps and drying time of 20.23 minutes.
{"title":"FORMULATION AND EVALUATION OF PEEL-OFF GEL MASK FROM EXTRACT OF RED SPINACH (Amaranthus tricolor L.)","authors":"Nurafifah Daud, Ade Ainun Insani, Eny Nurhikma","doi":"10.31603/pharmacy.v1i1.6095","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6095","url":null,"abstract":"Red spinach (Amaranthus tricolor L.) contains various secondary metabolites that act as antioxidants. These activities can be used to maintain the health of facial skin due to the negative impact of free radicals in the form of cosmetic preparations of peel-off gel mask. This study aims to make a peel-off gel mask preparation from red spinach extract that meets the requirements for physical evaluation of the preparation. The extraction process was carried out by maceration method using 96% ethanol as solvent. The thick extract was then made into a peel-off gel mask preparation with variations in extract concentration of 0.5% (F1), 1% (F2), and 2% (F3). Furthermore, physical evaluation of the preparation at room temperature for 4 weeks of storage, drying time test, irritation test, preference test, and cycling test was carried out. The red spinach used has been determined as Amaranthus tricolor L. The results of phytochemical screening of the thick extract showed that the extract contained positive alkaloids, saponins and flavonoids. The results of the evaluation showed that all preparations met the physical evaluation requirements and were not irritating. The higher the concentration of the extract, the darker the color of the preparation and the higher the pH and viscosity values. The preparation was stable during storage at room temperature but decreased in pH value and dispersion after passing 6 cycles of cycling test. The results of the preference test showed 60% of respondents liked F3, which is a formula with a dark green color, a distinctive aroma of red spinach, homogeneous, pH 7.54, dispersion of 6.2 cm, the viscosity of 7200 cps and drying time of 20.23 minutes.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43976754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-12DOI: 10.31603/pharmacy.v1i1.6120
W. _, Ajeng Diantini, M. Ghozali, S. I
Etlingera is one of the plant genera from the Zingiberaceae family and is widely distributed in Asia to the Pacific Islands, with various species ranging from 150 to 200 species. The Etlingera are commonly used as spices, vegetables, and traditional medicines. Many pharmacological activities have been reported from this genus, including antioxidants, antibacterials, cholesterol-lowering, anticancer, and others. The phytochemical content of Etlingera reported are phenolics, diarylheptanoids, flavonoids, steroids, alkaloids, and terpenoids. Eight species from Etlingera, namely Etlingera elatior, E. pavieana, E. brevilabrum, E. pyramidosphaera, E. megalocheilos, E. coccinea, E. fimbriobracteata, and E. corneri are reported provided anticancer activity. This review article aims to review the phytochemical screening from Etlingera genus, and its anticancer activity.
{"title":"ETLINGERA GENUS: PHYTOCHEMICAL SCREENING AND ANTICANCER ACTIVITY","authors":"W. _, Ajeng Diantini, M. Ghozali, S. I","doi":"10.31603/pharmacy.v1i1.6120","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6120","url":null,"abstract":"Etlingera is one of the plant genera from the Zingiberaceae family and is widely distributed in Asia to the Pacific Islands, with various species ranging from 150 to 200 species. The Etlingera are commonly used as spices, vegetables, and traditional medicines. Many pharmacological activities have been reported from this genus, including antioxidants, antibacterials, cholesterol-lowering, anticancer, and others. The phytochemical content of Etlingera reported are phenolics, diarylheptanoids, flavonoids, steroids, alkaloids, and terpenoids. Eight species from Etlingera, namely Etlingera elatior, E. pavieana, E. brevilabrum, E. pyramidosphaera, E. megalocheilos, E. coccinea, E. fimbriobracteata, and E. corneri are reported provided anticancer activity. This review article aims to review the phytochemical screening from Etlingera genus, and its anticancer activity.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47331387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-06DOI: 10.31603/pharmacy.v1i1.6146
Swaidatul Masluhiya AF, Irma _
Dengue Hemorrhagic Fever (DHF) is a disease caused by a virus which is still a public health problem whose number of sufferers is getting higher and its area of distribution is expanding which can cause death. DHF is also still endemic and continues to spread throughout the city of Malang. This research is descriptive qualitative research that aims to see the tendency of DHF cases in Malang City based on the variables of person, place and time of occurrence. The population and samples used were all data on DHF patients in Malang City which were obtained from the Malang City Health Office for the period 2015 - 2020 as many as 1.717 cases. The results of the data analysis of this study indicate that cases of DHF in Malang City always experience an increase from January to June with the highest peak in May every year, mostly 34.8% of DHF cases occur in Lowokwaru District and the majority (54.62%) are women and most (51.81%) are in the age group 15-44 years. There is a need for maximum prevention and control of dengue fever, especially before the increase in cases at the beginning of the year, especially in the Lowokwaru District which is the work area of the Dinoyo Public Health Center, Kendalsari and Mojolangu.
{"title":"EPIDEMIOLOGICAL ANALYSIS OF TRENDS IN DHF CASES IN MALANG CITY","authors":"Swaidatul Masluhiya AF, Irma _","doi":"10.31603/pharmacy.v1i1.6146","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6146","url":null,"abstract":"Dengue Hemorrhagic Fever (DHF) is a disease caused by a virus which is still a public health problem whose number of sufferers is getting higher and its area of distribution is expanding which can cause death. DHF is also still endemic and continues to spread throughout the city of Malang. This research is descriptive qualitative research that aims to see the tendency of DHF cases in Malang City based on the variables of person, place and time of occurrence. The population and samples used were all data on DHF patients in Malang City which were obtained from the Malang City Health Office for the period 2015 - 2020 as many as 1.717 cases. The results of the data analysis of this study indicate that cases of DHF in Malang City always experience an increase from January to June with the highest peak in May every year, mostly 34.8% of DHF cases occur in Lowokwaru District and the majority (54.62%) are women and most (51.81%) are in the age group 15-44 years. There is a need for maximum prevention and control of dengue fever, especially before the increase in cases at the beginning of the year, especially in the Lowokwaru District which is the work area of the Dinoyo Public Health Center, Kendalsari and Mojolangu.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48107563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-06DOI: 10.31603/pharmacy.v1i1.6143
Irma, Y. Sabilu
Malaria is one of the most common mosquito-borne infectious diseases in the world. Globally, deaths due to malaria infection reported in 2019 amounted to 405,000 deaths with a total number of sufferers of around 228 million cases. Although malaria cases have continued to decline in the last five years, including in Southeast Sulawesi Province, there are still regencies/cities in Southeast Sulawesi that have not been free from malaria. Therefore, this disease continues to be a burden of pain. This study aims to describe malaria cases in Southeast Sulawesi during the period from 2016 to 2020 based on epidemiological variables, namely people, place and time. The results showed that in general malaria cases from 2016 to 2020 showed a significant decline, based on place it can be seen that the Muna district was the area with the highest prevalence of malaria throughout the year of observation and North Konawe District as the area with the lowest malaria prevalence. From the people variable, the majority (67%) of malaria cases were men and only 33% were women. Meanwhile, based on the time in five years of observation, the highest malaria prevalence occurred in 2016 and the lowest was in 2020. Malaria prevention and control programs need to be carried out strictly to support the achievement of malaria elimination in all districts and cities in Southeast Sulawesi.
{"title":"CASE STUDY OF POSITIVE CONFIRMED MALARIA IN SOUTHEAST SULAWESI BASED ON EPIDEMIOLOGICAL VARIABLES","authors":"Irma, Y. Sabilu","doi":"10.31603/pharmacy.v1i1.6143","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6143","url":null,"abstract":"Malaria is one of the most common mosquito-borne infectious diseases in the world. Globally, deaths due to malaria infection reported in 2019 amounted to 405,000 deaths with a total number of sufferers of around 228 million cases. Although malaria cases have continued to decline in the last five years, including in Southeast Sulawesi Province, there are still regencies/cities in Southeast Sulawesi that have not been free from malaria. Therefore, this disease continues to be a burden of pain. This study aims to describe malaria cases in Southeast Sulawesi during the period from 2016 to 2020 based on epidemiological variables, namely people, place and time. The results showed that in general malaria cases from 2016 to 2020 showed a significant decline, based on place it can be seen that the Muna district was the area with the highest prevalence of malaria throughout the year of observation and North Konawe District as the area with the lowest malaria prevalence. From the people variable, the majority (67%) of malaria cases were men and only 33% were women. Meanwhile, based on the time in five years of observation, the highest malaria prevalence occurred in 2016 and the lowest was in 2020. Malaria prevention and control programs need to be carried out strictly to support the achievement of malaria elimination in all districts and cities in Southeast Sulawesi.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48427984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The impact of Corona Virus Disease-19 or COVID-19 pandemic was seen almost all aspects, especially in health facilities. Puskesmas as known as Public Health Center is a primary health service facility that usually became the first choice for seeking treatment so that Puskesmas can be said to be the backbone in facing and fighting the COVID-19 outbreak. This study aimed to determine the impact of the Covid-19 pandemic on drug management and the level of drug availability at Puuwatu Public Health Center, Kendari City. This study was descriptive-evaluative research with quantitative and qualitative methods and retrospective data collection in 2019 (before the pandemic) and 2020 (during the pandemic). Based on the results of the study, the percentage of the suitability of items with National Formulary increased by 1.3% during the pandemic, the percentage of the empty stock increased by 9.8%, the percentage value of damaged and expired items increased by 1.73%, the percentage of less stock decreased by 6, 43%, the percentage of safe stock and excess stock items decreased by 2.36% and 1.06%, respectively. The percentage value of suitability of the physical number of items did not change both in 2019 and in 2020 at the Puuwatu Health Center, Kendari City
{"title":"COVID-19 PANDEMIC'S IMPACT ON THE DRUG MANAGEMENT AND DRUG AVAILABILITY AT PUUWATU HEALTH CENTER, KENDARI CITY","authors":"Sabarudin Sabarudin, Sunandar Ihsan, Henny Kasmawati, Rifa’atul Mahmudah, Eka Pebriana","doi":"10.31603/pharmacy.v1i1.6129","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6129","url":null,"abstract":"The impact of Corona Virus Disease-19 or COVID-19 pandemic was seen almost all aspects, especially in health facilities. Puskesmas as known as Public Health Center is a primary health service facility that usually became the first choice for seeking treatment so that Puskesmas can be said to be the backbone in facing and fighting the COVID-19 outbreak. This study aimed to determine the impact of the Covid-19 pandemic on drug management and the level of drug availability at Puuwatu Public Health Center, Kendari City. This study was descriptive-evaluative research with quantitative and qualitative methods and retrospective data collection in 2019 (before the pandemic) and 2020 (during the pandemic). Based on the results of the study, the percentage of the suitability of items with National Formulary increased by 1.3% during the pandemic, the percentage of the empty stock increased by 9.8%, the percentage value of damaged and expired items increased by 1.73%, the percentage of less stock decreased by 6, 43%, the percentage of safe stock and excess stock items decreased by 2.36% and 1.06%, respectively. The percentage value of suitability of the physical number of items did not change both in 2019 and in 2020 at the Puuwatu Health Center, Kendari City","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47791507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.31603/pharmacy.v1i1.6084
D. Permatasari, Tatiana Siska Wardani, Ikrima Rahmasari, Kezia Putri Maha Dewi
Skin aging is a problem for women caused by external factors, namely exposure to free radicals such as sunlight, antiaging cosmetic products containing antioxidants have been widely circulated to maintain skin health from the effects of free radicals. The content of antioxidant chemical compounds in the purslane plant (Portulaca oleracea L.) is believed to be able to prevent free radicals. Purslane plant extract serum preparations were made by formulating preparations with ingredients such as HPMC, chitosan, tween 80. Furthermore, antioxidant testing of extracts and preparations of serum spray formulas was carried out using the DPPH method, after which evaluation of the preparations included homogeneity, pH, adhesion, viscosity, and hedonic. The preparation of purslane plant extract serum in the spray gel preparation produces a brownish green color, has a slightly sour smell and has a soft texture. The resulting viscosity in the serum ranged from 1330 - 1362 cPs with a pH value in the range of 5.67 - 5.72. From the hedonic test carried out, the results obtained were that the color and aroma were less favored by the panelists while for the convenience of using spray gel the panelists liked the texture of all purslane (Portulaca oleracea L.) plant extract formulas. Based on this research, the IC50 value of purslane (Portulaca oleracea L.) plant extract was 132.87 ppm, while the formula had an IC50 value of 83.91 ppm. Therefore, antiaging serum in spray gel formulation has stronger antioxidant activity than purslane (Portulaca oleracea L.) plant extract.
{"title":"ANTIOXIDANT ACTIVITY OF PURSLANE PLANT (Portulaca oleracea L.) EXTRACT AS AN ANTIAGING SERUM IN SPRAY GEL USING DPPH METHOD","authors":"D. Permatasari, Tatiana Siska Wardani, Ikrima Rahmasari, Kezia Putri Maha Dewi","doi":"10.31603/pharmacy.v1i1.6084","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6084","url":null,"abstract":"Skin aging is a problem for women caused by external factors, namely exposure to free radicals such as sunlight, antiaging cosmetic products containing antioxidants have been widely circulated to maintain skin health from the effects of free radicals. The content of antioxidant chemical compounds in the purslane plant (Portulaca oleracea L.) is believed to be able to prevent free radicals. Purslane plant extract serum preparations were made by formulating preparations with ingredients such as HPMC, chitosan, tween 80. Furthermore, antioxidant testing of extracts and preparations of serum spray formulas was carried out using the DPPH method, after which evaluation of the preparations included homogeneity, pH, adhesion, viscosity, and hedonic. The preparation of purslane plant extract serum in the spray gel preparation produces a brownish green color, has a slightly sour smell and has a soft texture. The resulting viscosity in the serum ranged from 1330 - 1362 cPs with a pH value in the range of 5.67 - 5.72. From the hedonic test carried out, the results obtained were that the color and aroma were less favored by the panelists while for the convenience of using spray gel the panelists liked the texture of all purslane (Portulaca oleracea L.) plant extract formulas. Based on this research, the IC50 value of purslane (Portulaca oleracea L.) plant extract was 132.87 ppm, while the formula had an IC50 value of 83.91 ppm. Therefore, antiaging serum in spray gel formulation has stronger antioxidant activity than purslane (Portulaca oleracea L.) plant extract.","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45722571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.31603/pharmacy.v1i1.6107
M. Y, Muhammad Syaiful Saehu, E. _, Irma _, N. _
Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05).
加灵植物(Cayratia trifolia L. Domin)是一种在印度尼西亚，特别是在低地广泛分布和容易发现的野生植物，其含有类黄酮、多酚、生物碱、萜类、三萜类等次生代谢产物，具有抗糖尿病、免疫调节、抗菌、抗真菌、止泻、痛风等多种药理活性。本研究旨在利用体外红细胞膜稳定模型来确定棒状多糖的几种组分的抗炎作用。本研究以正己烷、乙酸乙酯和水为溶剂，采用液液分离乙醇提取物。然后，检测各组分的抗炎作用，并以不同浓度双氯芬酸钠为阳性对照。抗炎活性的测定是根据红细胞膜的%稳定性来计算的。结果表明，以红细胞膜稳定性为指标，三叶草茎乙醇提取物的乙酸乙酯、正己烷和水组分均具有抗炎作用，其中乙酸乙酯浓度为1000 ppm的部位抗炎效果最好，红细胞膜稳定性为91.81%，与阳性对照差异显著(p<0.05)。
{"title":"ANTIINFLAMMATORY EFFECTS OF FRACTION FROM GALING STEM ETHANOL EXTRACT (Cayratia trifolia L. Domin) IN VITRO","authors":"M. Y, Muhammad Syaiful Saehu, E. _, Irma _, N. _","doi":"10.31603/pharmacy.v1i1.6107","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6107","url":null,"abstract":"Galing plant (Cayratia trifolia L. Domin) is a wild plant that spreads and is easily found in Indonesia, especially in the lowlands, which contains a class of secondary metabolites such as flavonoids, polyphenols, alkaloids, terpenoids, and triterpenoids with various pharmacological activities such as antidiabetic, immunomodulatory, antibacterial, anti-fungal, anti-diarrhea, gout. This study aims to determine the antiinflammatory effect of several fractions of rod galing using the in vitro model of red blood cell membrane stabilization. This study used an ethanol extract fractionated in a liquid-liquid manner with n-hexane, ethyl acetate, and water as a solvent. Then, the anti-inflammatory effect of each fraction was tested, with a positive control comparison of diclofenac sodium with varying concentrations. Measurement of anti-inflammatory activity was calculated based on the % stability of the red blood cell membrane. The results showed that the ethyl acetate, n-hexane and water fractions from the ethanol extract of galing (Cayratia trifolia L. Domin.) stem had an anti-inflammatory effect based on the % stability of red blood cell membranes, where the ethyl acetate fraction with a concentration of 1000 ppm had the best anti-inflammatory effect with % stability of red blood cell membranes was 91.81%, which was significantly different from the positive control (p<0.05).","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41688667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-05DOI: 10.31603/pharmacy.v1i1.6083
A. Jabbar, W. _, Mesi Leorita, M. Yusuf, S. _
Plants Etlingera elatior (Wualae) is a family Zingiberaceae of the genus Etlingera which has a large population in the world. The E. elatior plant is widely used empirically in the community to increase endurance and seasoning in fruit. In this study, ethanol extract was used to determine its potential and effectiveness as an antihyperuricemia (in vivo) was tested pharmacologically on Rattus novergicus L. In this study, twenty-four rats were grouped into six groups, namely the ethanol extract of wualae fruit at a dose (100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW), and the negative control group Sodium CMC 0 .5%, and the positive control group used Allopurinol 10 mg/kgBW. Furthermore, To increase the value of uric acid levels, the rats were first induced with 250 mg/kgBW Potassium Oxonate via intraperitoneal (i.p). Furthermore, the preparation according to the treatment was given orally one hour later after the administration of potassium oxonate. At the hour (1, 2, 3), the blood was taken intravenously (i.v) through the rat's tail, and then the uric acid level was analyzed with a photometer. All doses used in this study, namely 100, 200, 300, and 400 mg/kgBW, showed that they could reduce uric acid overall. The effective dose used is the dose (300 mg/kgBW, 400 mg/kgBW). This research can be concluded that the ethanol extract of the fruit of Etlingera elatior (Jack) R.M. Smith (Wualae) has potential as an antihyperuricemia (uric acid) and can be developed as a traditional medicine
{"title":"ANTIHYPERURICEMIA ACTIVITY OF WUALAE FRUIT (Etlingera elatior Jack R. M. Smith) ETHANOL EXTRACT IN VIVO","authors":"A. Jabbar, W. _, Mesi Leorita, M. Yusuf, S. _","doi":"10.31603/pharmacy.v1i1.6083","DOIUrl":"https://doi.org/10.31603/pharmacy.v1i1.6083","url":null,"abstract":"Plants Etlingera elatior (Wualae) is a family Zingiberaceae of the genus Etlingera which has a large population in the world. The E. elatior plant is widely used empirically in the community to increase endurance and seasoning in fruit. \u0000In this study, ethanol extract was used to determine its potential and effectiveness as an antihyperuricemia (in vivo) was tested pharmacologically on Rattus novergicus L. In this study, twenty-four rats were grouped into six groups, namely the ethanol extract of wualae fruit at a dose (100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW), and the negative control group Sodium CMC 0 .5%, and the positive control group used Allopurinol 10 mg/kgBW. Furthermore, To increase the value of uric acid levels, the rats were first induced with 250 mg/kgBW Potassium Oxonate via intraperitoneal (i.p). Furthermore, the preparation according to the treatment was given orally one hour later after the administration of potassium oxonate. At the hour (1, 2, 3), the blood was taken intravenously (i.v) through the rat's tail, and then the uric acid level was analyzed with a photometer. All doses used in this study, namely 100, 200, 300, and 400 mg/kgBW, showed that they could reduce uric acid overall. The effective dose used is the dose (300 mg/kgBW, 400 mg/kgBW). This research can be concluded that the ethanol extract of the fruit of Etlingera elatior (Jack) R.M. Smith (Wualae) has potential as an antihyperuricemia (uric acid) and can be developed as a traditional medicine","PeriodicalId":17722,"journal":{"name":"Jurnal Farmasi Sains dan Praktis","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45531337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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