Pub Date : 2020-07-20DOI: 10.11150/KANSENSHOGAKUZASSHI.94.553
K. Takada, J. Takatsuka, Chihiro Onagi, Kimi Yoshida, Kazuo Ueda, N. Tokura, Taro Nakano, T. Kinoshita, A. Oki, T. Fujii, A. Ebihara
Our hospital was introduced in the media as the hospital at which the first patient who died of COVID-19 infection in Japan was hospitalized Patients with pneumonia associated with COVID-19 sometimes show rapid deterioration of the respiratory status, with a poor prognosis The cases encountered by us that we report here also needed intensive long-term respiratory management ARDS is an important pathological condition complicating COVID-19 pneumonia From the perspective of the continuing pathology of ARDS, we treated the patients with a steroid and sivelestat However, it became clear that the respiratory pathology in the patients could not be adequately addressed by the uniform treatment protocol for ARDS In conclusion, inpatient treatment in a local community-based small hospital without an ICU can be extremely difficult
{"title":"Report on the Difficulty in Infection Control and Treatment of Patients with Severe COVID-19 Pneumonia Who Required Assisted Ventilation and Ventilator Management at a Local Community-based Hospital in Japan","authors":"K. Takada, J. Takatsuka, Chihiro Onagi, Kimi Yoshida, Kazuo Ueda, N. Tokura, Taro Nakano, T. Kinoshita, A. Oki, T. Fujii, A. Ebihara","doi":"10.11150/KANSENSHOGAKUZASSHI.94.553","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.94.553","url":null,"abstract":"Our hospital was introduced in the media as the hospital at which the first patient who died of COVID-19 infection in Japan was hospitalized Patients with pneumonia associated with COVID-19 sometimes show rapid deterioration of the respiratory status, with a poor prognosis The cases encountered by us that we report here also needed intensive long-term respiratory management ARDS is an important pathological condition complicating COVID-19 pneumonia From the perspective of the continuing pathology of ARDS, we treated the patients with a steroid and sivelestat However, it became clear that the respiratory pathology in the patients could not be adequately addressed by the uniform treatment protocol for ARDS In conclusion, inpatient treatment in a local community-based small hospital without an ICU can be extremely difficult","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"21 1","pages":"553-562"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91084656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.11150/KANSENSHOGAKUZASSHI.94.545
K. Nishida, Y. Ogawa, S. Yoshihara, I. Gohma
The patient was a 56-year-old man who presented with a 14-day history of fever, and had been diagnosed by a physician as having pneumonia on the basis of the findings of chest CT He had not travelled abroad and gave no history of close contact with any patients with suspected or confirmed COVID-19 His chest CT showed bilateral multiple ground-glass opacities, distributed predominantly in the peripheral lung regions We suspected COVID-19 pneumonia based on the chest CT findings A nasopharyngeal swab PCR test (PCR) for SARS-CoV-2 on day 1 returned a negative result The following day, a nasopharyngeal swab and a sputum specimen were submitted for repeat PCR testing, and both yielded positive results, confirming the diagnosis of COVID-19 pneumonia in the patient
{"title":"A Case of COVID-19 Suspected from the Findings of Chest CT, with the Diagnosis Confirmed by a Second PCR Test；Unknown Infection Route","authors":"K. Nishida, Y. Ogawa, S. Yoshihara, I. Gohma","doi":"10.11150/KANSENSHOGAKUZASSHI.94.545","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.94.545","url":null,"abstract":"The patient was a 56-year-old man who presented with a 14-day history of fever, and had been diagnosed by a physician as having pneumonia on the basis of the findings of chest CT He had not travelled abroad and gave no history of close contact with any patients with suspected or confirmed COVID-19 His chest CT showed bilateral multiple ground-glass opacities, distributed predominantly in the peripheral lung regions We suspected COVID-19 pneumonia based on the chest CT findings A nasopharyngeal swab PCR test (PCR) for SARS-CoV-2 on day 1 returned a negative result The following day, a nasopharyngeal swab and a sputum specimen were submitted for repeat PCR testing, and both yielded positive results, confirming the diagnosis of COVID-19 pneumonia in the patient","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"29 1","pages":"545-548"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89855410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.11150/KANSENSHOGAKUZASSHI.94.573
T. Terashima, T. Shimada, Tatsu Matsuzaki, T. Nakajima, Eri Iwami, Aoi Kuroda
{"title":"A Cluster of Three Cases of COVID-19 Pneumonia Contracted from a Healthcare Worker","authors":"T. Terashima, T. Shimada, Tatsu Matsuzaki, T. Nakajima, Eri Iwami, Aoi Kuroda","doi":"10.11150/KANSENSHOGAKUZASSHI.94.573","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.94.573","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"37 1","pages":"573-578"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75421184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.11150/KANSENSHOGAKUZASSHI.94.549
H. Nakaoka, M. Shiraga, Miki Kitamura, Mikiko Chikamori, T. Kitamura, M. Ishida
This is a case report of a male patient in his 50s who developed pneumonia while he was admitted at another hospital The patient received antibacterial drugs, but showed no improvement He was referred to our hospital for further investigation and treatment of pneumonia We made the diagnosis of COVID-19 promptly, based on the clinical history, laboratory results, and chest CT findings This case highlights the importance of carefully observing the patient's clinical course and performing appropriate examinations to make a prompt diagnosis of COVID-19
{"title":"A Case of Pneumonia Caused by Severe Acute Respiratory Syndrome-coronavirus-2 (SARS-CoV-2) that Developed While the Patient was Admitted at Another Hospital","authors":"H. Nakaoka, M. Shiraga, Miki Kitamura, Mikiko Chikamori, T. Kitamura, M. Ishida","doi":"10.11150/KANSENSHOGAKUZASSHI.94.549","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.94.549","url":null,"abstract":"This is a case report of a male patient in his 50s who developed pneumonia while he was admitted at another hospital The patient received antibacterial drugs, but showed no improvement He was referred to our hospital for further investigation and treatment of pneumonia We made the diagnosis of COVID-19 promptly, based on the clinical history, laboratory results, and chest CT findings This case highlights the importance of carefully observing the patient's clinical course and performing appropriate examinations to make a prompt diagnosis of COVID-19","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"25 1","pages":"549-552"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81555871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-07-20DOI: 10.11150/KANSENSHOGAKUZASSHI.94.495
Yotaro Takaku, K. Kurashima, T. Ishiguro, N. Kagiyama, T. Numano, Mayumi Koike, S. Yokota, K. Takano, T. Isono, T. Nishida, E. Kawate, C. Hosoda, Yoichi Kobayashi, T. Yanagisawa
An immunochromatographic assay that has been developed for the detection of antibodies in blood-derived specimens is raising expectations for the diagnosis of COVID-19, the disease caused by the novel corona virus SARS-CoV-2 Herein, we studied the interval from symptom onset to the first positive results of the immunochromatographic assay for IgM and IgG antibodies in 52 patients with a definitive diagnosis of COVID-19 (disease confirmed by the PCR test) Furthermore, we also examined the test results in 35 patients with acute fever and pneumonia who were negative by the PCR test All patients with a definitive diagnosis of COVID-19 were confirmed to be antibody-positive The mean time from symptom onset to the first positive result for IgM antibody was 11 9 days (minimum: 5, median: 11), and that to the first positive result for IgG antibody was 11 2 days (minimum: 5, median: 11) No significant difference was observed between the tests for IgM and IgG antibodies in terms of the percentage of positive patients or the interval from first onset to the first positive test result There were no patients in whom the test for IgM became positive before the test for IgG In 45 patients (87%), both IgM and IgG became positive at the same time, and in the remaining 7 patients (13%), the test for IgG became positive before that for IgM Of 35 patients with acute fever and pneumonia who tested negative by the PCR test for SARS-CoV-2, not COVID-19, 6 (17 1%) and 1 (2 8%) showed positive results for anti-IgG antibody and anti-IgM antibody, respectively Our study results were quite limited, and we do not intend to conduct a performance evaluation of the reagents contained in the detection kits Assessment of antibody detection reagents for the immunochromatographic assay, which can be used as a complementary test to PCR, is expected in the future;however, the findings should be reviewed carefully
{"title":"Antibody Response as Assessed by A Rapid Immunochromatographic Assay in Patients with COVID-19 Pneumonia Caused by the Novel Coronavirus, SARS-CoV-2","authors":"Yotaro Takaku, K. Kurashima, T. Ishiguro, N. Kagiyama, T. Numano, Mayumi Koike, S. Yokota, K. Takano, T. Isono, T. Nishida, E. Kawate, C. Hosoda, Yoichi Kobayashi, T. Yanagisawa","doi":"10.11150/KANSENSHOGAKUZASSHI.94.495","DOIUrl":"https://doi.org/10.11150/KANSENSHOGAKUZASSHI.94.495","url":null,"abstract":"An immunochromatographic assay that has been developed for the detection of antibodies in blood-derived specimens is raising expectations for the diagnosis of COVID-19, the disease caused by the novel corona virus SARS-CoV-2 Herein, we studied the interval from symptom onset to the first positive results of the immunochromatographic assay for IgM and IgG antibodies in 52 patients with a definitive diagnosis of COVID-19 (disease confirmed by the PCR test) Furthermore, we also examined the test results in 35 patients with acute fever and pneumonia who were negative by the PCR test All patients with a definitive diagnosis of COVID-19 were confirmed to be antibody-positive The mean time from symptom onset to the first positive result for IgM antibody was 11 9 days (minimum: 5, median: 11), and that to the first positive result for IgG antibody was 11 2 days (minimum: 5, median: 11) No significant difference was observed between the tests for IgM and IgG antibodies in terms of the percentage of positive patients or the interval from first onset to the first positive test result There were no patients in whom the test for IgM became positive before the test for IgG In 45 patients (87%), both IgM and IgG became positive at the same time, and in the remaining 7 patients (13%), the test for IgG became positive before that for IgM Of 35 patients with acute fever and pneumonia who tested negative by the PCR test for SARS-CoV-2, not COVID-19, 6 (17 1%) and 1 (2 8%) showed positive results for anti-IgG antibody and anti-IgM antibody, respectively Our study results were quite limited, and we do not intend to conduct a performance evaluation of the reagents contained in the detection kits Assessment of antibody detection reagents for the immunochromatographic assay, which can be used as a complementary test to PCR, is expected in the future;however, the findings should be reviewed carefully","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"5 1","pages":"495-499"},"PeriodicalIF":0.0,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85389262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.11150/kansenshogakuzasshi.94.321
Haruto Yamada, Takashi Saito, M. Makita, T. Shibayama
{"title":"Catheter-related Blood Stream Infection from a Hickman Catheter Injection Cap by Rhizobium radiobacter","authors":"Haruto Yamada, Takashi Saito, M. Makita, T. Shibayama","doi":"10.11150/kansenshogakuzasshi.94.321","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.94.321","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"120 1","pages":"321-324"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86093775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.11150/kansenshogakuzasshi.94.332
Yoji Uejima, J. Kurihara, Mihoko Furuichi, Satoshi Sato, H. Niimi, Y. Kawano, T. Oh‐ishi, Eisuke Suganuma
{"title":"A Case of a Brain Abscess with Streptococcus intermedius Rapidly Diagnosed with the Melting Temperature Mapping Method","authors":"Yoji Uejima, J. Kurihara, Mihoko Furuichi, Satoshi Sato, H. Niimi, Y. Kawano, T. Oh‐ishi, Eisuke Suganuma","doi":"10.11150/kansenshogakuzasshi.94.332","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.94.332","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"21 1","pages":"332-337"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83576694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.11150/kansenshogakuzasshi.94.325
Keigo Kimura, H. Hagiya, Tomomi Mitsui, I. Nishi, K. Tomono
{"title":"A Case of Cutaneously Disseminated Mycobacterium haemophilum Infection Accompanying Blood Stream Infection","authors":"Keigo Kimura, H. Hagiya, Tomomi Mitsui, I. Nishi, K. Tomono","doi":"10.11150/kansenshogakuzasshi.94.325","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.94.325","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"25 1","pages":"325-331"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82185551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.11150/kansenshogakuzasshi.94.310
S. Teranaka, Katsuaki A Abe, K. Shizuno, M. Terai
{"title":"Annual Change in the Antimicrobial Susceptibility of Enterobacteriaceae Strains Isolated from Urine Specimens of Children Admitted to Chiba Kaihin Municipal Hospital for Febrile Urinary Tract Infection between 2009 and 2018","authors":"S. Teranaka, Katsuaki A Abe, K. Shizuno, M. Terai","doi":"10.11150/kansenshogakuzasshi.94.310","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.94.310","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"43 1","pages":"310-316"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84728021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-20DOI: 10.11150/kansenshogakuzasshi.94.304
T. Kurosaki
{"title":"Change of Outpatient Antibiotic Prescriptions in the Clinic in Cooperation with Community Pharmacies","authors":"T. Kurosaki","doi":"10.11150/kansenshogakuzasshi.94.304","DOIUrl":"https://doi.org/10.11150/kansenshogakuzasshi.94.304","url":null,"abstract":"","PeriodicalId":17724,"journal":{"name":"Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases","volume":"12 1","pages":"304-309"},"PeriodicalIF":0.0,"publicationDate":"2020-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90603784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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