Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p12
Edenia Asisaratu, Rizaldy T. Pinzon, Esdras Ardi Pramudita
Latar Belakang: Nyeri neuropati diabetika menjadi komplikasi penyakit Diabetes Mellitus yang paling sering terjadi dan dapat menjadi beban sehingga dibutuhkan pengobatan optimal. Pengobatan saat ini yaitu terapi simtomatik dengan kontrol indeks glikemik namun belum dapat mencapai target optimal. Penelitian terdahulu menunjukkan suplementasi vitamin B dan vitamin D dapat memberikan pengurangan nyeri yang signifikan. Cara Kerja: Penelitian ini dilakukan menggunakan metode kohort retrospektif. Pengambilan sampel dilakukan menggunakan metode consecutive sampling dengan total sampel 107 subjek yang mendapatkan terapi simtomatik atau terapi simtomatik ditambah vitamin. Terapi diberikan selama tiga bulan. Pengukuran skala nyeri dilakukan dengan menggunakan Neuropathic Pain Scale. Hasil: Penelitian ini membandingkan subjek dalam tiga kelompok perbandingan. Pada kelompok perbandingan pertama, pengurangan nyeri paling besar pada kelompok terapi simtomatik ditambah vitamin (39,50±14,222) (p=0,000). Pada kelompok perbandingan kedua, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah kombinasi vitamin B dan vitamin D 1000 IU (53,00±6,749) (p=0,000). Pada kelompok perbandingan ketiga, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah vitamin D 1000 IU (44,00±8,944) (p=0,088). Kesimpulan: Terapi tambahan vitamin mengakibatkan pengurangan nyeri yang lebih besar secara bermakna dibandingkan terapi simtomatik saja. Tidak terdapat perbedaan penurunan nyeri yang bermakna antara penambahan vitamin D 400 IU dengan vitamin D 1000 IU. Kata kunci: intensitas nyeri; nyeri neuropati diabetika; vitamin B; vitamin D
{"title":"Manfaat Terapi Tambahan Vitamin pada Pasien Nyeri Neuropati Diabetika","authors":"Edenia Asisaratu, Rizaldy T. Pinzon, Esdras Ardi Pramudita","doi":"10.24843/jfu.2023.v12.i01.p12","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p12","url":null,"abstract":"Latar Belakang: Nyeri neuropati diabetika menjadi komplikasi penyakit Diabetes Mellitus yang paling sering terjadi dan dapat menjadi beban sehingga dibutuhkan pengobatan optimal. Pengobatan saat ini yaitu terapi simtomatik dengan kontrol indeks glikemik namun belum dapat mencapai target optimal. Penelitian terdahulu menunjukkan suplementasi vitamin B dan vitamin D dapat memberikan pengurangan nyeri yang signifikan. Cara Kerja: Penelitian ini dilakukan menggunakan metode kohort retrospektif. Pengambilan sampel dilakukan menggunakan metode consecutive sampling dengan total sampel 107 subjek yang mendapatkan terapi simtomatik atau terapi simtomatik ditambah vitamin. Terapi diberikan selama tiga bulan. Pengukuran skala nyeri dilakukan dengan menggunakan Neuropathic Pain Scale. Hasil: Penelitian ini membandingkan subjek dalam tiga kelompok perbandingan. Pada kelompok perbandingan pertama, pengurangan nyeri paling besar pada kelompok terapi simtomatik ditambah vitamin (39,50±14,222) (p=0,000). Pada kelompok perbandingan kedua, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah kombinasi vitamin B dan vitamin D 1000 IU (53,00±6,749) (p=0,000). Pada kelompok perbandingan ketiga, pengurangan nyeri paling besar terdapat pada kelompok terapi simtomatik ditambah vitamin D 1000 IU (44,00±8,944) (p=0,088). Kesimpulan: Terapi tambahan vitamin mengakibatkan pengurangan nyeri yang lebih besar secara bermakna dibandingkan terapi simtomatik saja. Tidak terdapat perbedaan penurunan nyeri yang bermakna antara penambahan vitamin D 400 IU dengan vitamin D 1000 IU. \u0000Kata kunci: intensitas nyeri; nyeri neuropati diabetika; vitamin B; vitamin D","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79873331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p03
Siti Jubaedah
— Pediculosis capitis is an infection of the scalp and skin caused by Pediculus humanus var. capitis, which is still common today. Pediculicidal from plants has been widely recommended as an alternative pediculicide because it has a low toxicity effect on humans. This study aims to determine the potential of papaya seed ethanol extract on the death of Pediculus humanus var. capitis. The study used five head lice in each treatment group. The test was carried out with five concentration treatments, namely concentrations of 5%, 10%, 15%, 20%, and 40%. The control used was a positive control, namely 1% permethrin, and negative control, namely aquabides. This research was conducted with three times repetition. The results showed concentrations of 15%, 20%, 40%, and positive control had a high percentage of mortality, namely 100%, 10% concentration was 80% mortality, the lowest lice mortality was 5% concentration of 60%, and negative control was 0%. This research obtained the results of LC50 is 9,685%, while LC90 is 12,038%. The results of the phytochemical test showed that the ethanol extract of papaya seeds contained alkaloids
{"title":"Studi Potensi Ekstrak Etanol Biji Pepaya (Carica papaya L.) sebagai Pedikulisidal Semprot terhadap Kutu Pediculus humanus var. capitis","authors":"Siti Jubaedah","doi":"10.24843/jfu.2023.v12.i01.p03","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p03","url":null,"abstract":"— Pediculosis capitis is an infection of the scalp and skin caused by Pediculus humanus var. capitis, which is still common today. Pediculicidal from plants has been widely recommended as an alternative pediculicide because it has a low toxicity effect on humans. This study aims to determine the potential of papaya seed ethanol extract on the death of Pediculus humanus var. capitis. The study used five head lice in each treatment group. The test was carried out with five concentration treatments, namely concentrations of 5%, 10%, 15%, 20%, and 40%. The control used was a positive control, namely 1% permethrin, and negative control, namely aquabides. This research was conducted with three times repetition. The results showed concentrations of 15%, 20%, 40%, and positive control had a high percentage of mortality, namely 100%, 10% concentration was 80% mortality, the lowest lice mortality was 5% concentration of 60%, and negative control was 0%. This research obtained the results of LC50 is 9,685%, while LC90 is 12,038%. The results of the phytochemical test showed that the ethanol extract of papaya seeds contained alkaloids","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88610963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p06
Abdullah Qosim
Abstract— Lip cream is a semi-solid to liquid textured preparation that functions as a lip dye. Tomato plants can be used as natural dyes because they contain lycopene compounds which can give a yellow to red color. This study aims to determine whether tomato fruit extract can be formulated as a dye, determine the effect of adding tomato extract concentration and determine the halal critical point in the preparation of tomato fruit extract lip cream as a natural dye. The tomato fruit extraction method was carried out using UAE with methanol solvent. The resulting extract was then added to each formula with concentrations of F0 (0%), F1 (5%), F2 (10%) and F3 (15%). The organoleptic test results showed that all formulas had a semi-solid texture, smelled of roses and F0 was white, F1 was light orange, F2 was orange and F3 was brick red. All formulas comply with the homogeneity and pH test standards as indicated by the pH value range of 6.47 - 5.17. All formulas had good smearing power, adhesion of ?60 seconds and spreadability test values ??ranging from 5.90 to 5.63. The results of the ANOVA analysis on the pH and spreadability tests showed that the preparations had significant differences between the formulas. Evaluation of halal critical points on preparations does not have halal critical points in terms of materials and processing.
{"title":"Formulasi dan Evaluasi Lip cream Halal Menggunakan Ekstrak Tomat (Lycopersicon esculentum Mill) Sebagai Pewarna Alami","authors":"Abdullah Qosim","doi":"10.24843/jfu.2023.v12.i01.p06","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p06","url":null,"abstract":"Abstract— Lip cream is a semi-solid to liquid textured preparation that functions as a lip dye. Tomato plants can be used as natural dyes because they contain lycopene compounds which can give a yellow to red color. This study aims to determine whether tomato fruit extract can be formulated as a dye, determine the effect of adding tomato extract concentration and determine the halal critical point in the preparation of tomato fruit extract lip cream as a natural dye. The tomato fruit extraction method was carried out using UAE with methanol solvent. The resulting extract was then added to each formula with concentrations of F0 (0%), F1 (5%), F2 (10%) and F3 (15%). The organoleptic test results showed that all formulas had a semi-solid texture, smelled of roses and F0 was white, F1 was light orange, F2 was orange and F3 was brick red. All formulas comply with the homogeneity and pH test standards as indicated by the pH value range of 6.47 - 5.17. All formulas had good smearing power, adhesion of ?60 seconds and spreadability test values ??ranging from 5.90 to 5.63. The results of the ANOVA analysis on the pH and spreadability tests showed that the preparations had significant differences between the formulas. Evaluation of halal critical points on preparations does not have halal critical points in terms of materials and processing.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85045299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p04
Alma Yunita Sari, Ellin Febrina
Breast cancer is one of the leading causes of death in women worldwide. Breast cancer can be triggered due to physical, chemical, environmental factors and can be passed down from generation to generation through genetics. Therefore, recently, studies have been intensively conducted on the use of medicinal plants for the treatment of breast cancer as an alternative because they have minimal side effects compared to other chemotherapy. This review aims to describe medicinal plants and their active compounds that have the potential as anticancer therapy which has been carried out in silico studies with molecular anchoring methods. The method used in writing this article is a literature review both nationally and internationally over the last five years using the keywords breast cancer, molecular docking, herbal plants, anticancer, in databases such as PubMed, Cochrane, and Google Scholar. Herbal plants in in silico research that have high potential for further research as cancer therapy include 33 herbal plants with different active compounds and protein targets.
{"title":"Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel","authors":"Alma Yunita Sari, Ellin Febrina","doi":"10.24843/jfu.2023.v12.i01.p04","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p04","url":null,"abstract":"Breast cancer is one of the leading causes of death in women worldwide. Breast cancer can be triggered due to physical, chemical, environmental factors and can be passed down from generation to generation through genetics. Therefore, recently, studies have been intensively conducted on the use of medicinal plants for the treatment of breast cancer as an alternative because they have minimal side effects compared to other chemotherapy. This review aims to describe medicinal plants and their active compounds that have the potential as anticancer therapy which has been carried out in silico studies with molecular anchoring methods. The method used in writing this article is a literature review both nationally and internationally over the last five years using the keywords breast cancer, molecular docking, herbal plants, anticancer, in databases such as PubMed, Cochrane, and Google Scholar. Herbal plants in in silico research that have high potential for further research as cancer therapy include 33 herbal plants with different active compounds and protein targets.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79777327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p08
Baha Udin, Renditya Ismiyati, Renditya Ismiyati, Eva Kholifah, Endah Endah, Endah Endah
Indonesia dikenal memiliki beragam jenis tanaman yang dapat digunakan dalam pengobatan, salah satunya adalah ketepeng cina. Ketepeng cina merupakan salah satu tanaman yang memiliki banyak khasiat sehingga dapat digunakan sebagai pengobatan herbal atau obat tradisional. Salah satu khasiat tanaman ketepeng cina yang telah banyak di teliti yaitu sebagai antijamur. Pada setiap bagain tanaman ketepeng cina memiliki metabolit sekunder. Daun ketepeng cina mengandung metabolit sekunder alkaloid, steroid, fenol, glikosida, terpenoid, dan flavanoid. Bunga ketepeng cina mengandung senyawa flavonoid, tanin dan fenolik dan saponin. Tingkai ketepeng cina memiliki kandungan alkaloid, flavonoid, glikosid, fitosterol, kuinon, tanin dan terpenoid. Senyawa yang memiliki peran atau aktivitas antijamur pada tanaman ketepeng cina, yaitu fenolik, tannin, flavonoid, saponin, triterpenoid, steroid, dan alkaloid.
{"title":"Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur","authors":"Baha Udin, Renditya Ismiyati, Renditya Ismiyati, Eva Kholifah, Endah Endah, Endah Endah","doi":"10.24843/jfu.2023.v12.i01.p08","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p08","url":null,"abstract":"Indonesia dikenal memiliki beragam jenis tanaman yang dapat digunakan dalam pengobatan, salah satunya adalah ketepeng cina. Ketepeng cina merupakan salah satu tanaman yang memiliki banyak khasiat sehingga dapat digunakan sebagai pengobatan herbal atau obat tradisional. Salah satu khasiat tanaman ketepeng cina yang telah banyak di teliti yaitu sebagai antijamur. Pada setiap bagain tanaman ketepeng cina memiliki metabolit sekunder. Daun ketepeng cina mengandung metabolit sekunder alkaloid, steroid, fenol, glikosida, terpenoid, dan flavanoid. Bunga ketepeng cina mengandung senyawa flavonoid, tanin dan fenolik dan saponin. Tingkai ketepeng cina memiliki kandungan alkaloid, flavonoid, glikosid, fitosterol, kuinon, tanin dan terpenoid. Senyawa yang memiliki peran atau aktivitas antijamur pada tanaman ketepeng cina, yaitu fenolik, tannin, flavonoid, saponin, triterpenoid, steroid, dan alkaloid.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135088372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p05
Ilhammudin Sirait, Husnarika Febriani, Syukriah
Suatu kondisi metabolik yang disebut diabetes melitus (DM) diakibatkan oleh ketidakmampuan untuk mengeluarkan insulin. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol daun karanda (Carissa carandas L.) terhadap morfologi dan histologi ginjal tikus diabetes. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan enam kelompok variasi yaitu kelompok glibenklamid, kontrol normal, kontrol negatif. P1: dosis ekstrak daun karanda 500 mg/kg BB, P2: dosis ekstrak daun karanda 750 mg/kg BB, dan P3: Dosis ekstrak daun karanda 1000 mg/kg BB. Pewarnaan hematoksilin-eosin (HE) dan metode parafin untuk preparasi histopatologi ginjal tikus. Tes tindak lanjut Anova dan Duncan digunakan dalam analisis data dalam satu metode. Temuan menunjukkan perbedaan substansial antara kelompok kontrol dan perlakuan dalam morfologi dan histologi ginjal tikus diabetes. Histologi ginjal tikus diabetes menunjukkan edema glomerulus, destruksi sel berupa degenerasi hidropik dan nekrosis tubulus proksimal, serta modifikasi lebar glomerulus. Pemberian ekstrak etanol daun karanda dapat membantu mengatasi edema glomerulus, bentuk, dan penyembuhan sel tubulus proksimal. Mungkin relevan bahwa morfologi ginjal, histologi, dan diameter glomerulus tikus (Rattus norvegicus) dengan diabetes mellitus ditingkatkan oleh ekstrak etanol daun karanda, dengan dosis ekstrak yang paling efektif adalah 1000 mg/kgbb. Kata Kunci : Diabetes Melitus, Daun Karanda (Carissa carandas L.) dan Ginjal
{"title":"PENGARUH EKSTRAK ETANOL DAUN KARANDA (Carissa carandas L.) TERHADAP HISTOPATOLOGI GINJAL TIKUS PUTIH (rattus norvegicus) YANG DIINDUKSI ALOKSAN","authors":"Ilhammudin Sirait, Husnarika Febriani, Syukriah","doi":"10.24843/jfu.2023.v12.i01.p05","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p05","url":null,"abstract":"Suatu kondisi metabolik yang disebut diabetes melitus (DM) diakibatkan oleh ketidakmampuan untuk mengeluarkan insulin. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol daun karanda (Carissa carandas L.) terhadap morfologi dan histologi ginjal tikus diabetes. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan enam kelompok variasi yaitu kelompok glibenklamid, kontrol normal, kontrol negatif. P1: dosis ekstrak daun karanda 500 mg/kg BB, P2: dosis ekstrak daun karanda 750 mg/kg BB, dan P3: Dosis ekstrak daun karanda 1000 mg/kg BB. Pewarnaan hematoksilin-eosin (HE) dan metode parafin untuk preparasi histopatologi ginjal tikus. Tes tindak lanjut Anova dan Duncan digunakan dalam analisis data dalam satu metode. Temuan menunjukkan perbedaan substansial antara kelompok kontrol dan perlakuan dalam morfologi dan histologi ginjal tikus diabetes. Histologi ginjal tikus diabetes menunjukkan edema glomerulus, destruksi sel berupa degenerasi hidropik dan nekrosis tubulus proksimal, serta modifikasi lebar glomerulus. Pemberian ekstrak etanol daun karanda dapat membantu mengatasi edema glomerulus, bentuk, dan penyembuhan sel tubulus proksimal. Mungkin relevan bahwa morfologi ginjal, histologi, dan diameter glomerulus tikus (Rattus norvegicus) dengan diabetes mellitus ditingkatkan oleh ekstrak etanol daun karanda, dengan dosis ekstrak yang paling efektif adalah 1000 mg/kgbb. \u0000Kata Kunci : Diabetes Melitus, Daun Karanda (Carissa carandas L.) dan Ginjal","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74307945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p10
N. K. Warditiani, Pande Made, Nova Armita Sari, Ni Made, Widi Astuti
Emblica officinalis (Amla) is a plant that is not widely utilized in Bali, but it has tremendous potential. This study aims to investigate the antioxidant and anti-dyslipidemia potential of Amla. Literature search was conducted on Pubmed, Scopus, and Science Direct, followed by screening and review to match the inclusion and exclusion criteria. The search resulted in 346 articles, and after reviewing and screening the titles, keywords, and abstracts, 12 articles that met the criteria were obtained. The review findings indicate that Emblica officinalis (Amla) has a strong potential in preventing or addressing cardiovascular disorders such as atherosclerosis due to its abilities as a potential anti-dyslipidemia and antioxidant agent.
{"title":"Review potensi Emblica officinalis (Amla) dalam mengatasi gangguan metabolisme dislipidemia dan antioksidan","authors":"N. K. Warditiani, Pande Made, Nova Armita Sari, Ni Made, Widi Astuti","doi":"10.24843/jfu.2023.v12.i01.p10","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p10","url":null,"abstract":"Emblica officinalis (Amla) is a plant that is not widely utilized in Bali, but it has tremendous potential. This study aims to investigate the antioxidant and anti-dyslipidemia potential of Amla. Literature search was conducted on Pubmed, Scopus, and Science Direct, followed by screening and review to match the inclusion and exclusion criteria. The search resulted in 346 articles, and after reviewing and screening the titles, keywords, and abstracts, 12 articles that met the criteria were obtained. The review findings indicate that Emblica officinalis (Amla) has a strong potential in preventing or addressing cardiovascular disorders such as atherosclerosis due to its abilities as a potential anti-dyslipidemia and antioxidant agent.","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87673962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p09
Ni Luh, Putu Indah Suryani, Putu Yogi, Astara Putra, I. Nonye, T. Ujam, dan Ni, Putu Ariantari
The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites
{"title":"Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung","authors":"Ni Luh, Putu Indah Suryani, Putu Yogi, Astara Putra, I. Nonye, T. Ujam, dan Ni, Putu Ariantari","doi":"10.24843/jfu.2023.v12.i01.p09","DOIUrl":"https://doi.org/10.24843/jfu.2023.v12.i01.p09","url":null,"abstract":"The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future. \u0000Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites","PeriodicalId":17752,"journal":{"name":"Jurnal Farmasi Udayana","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81773519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-28DOI: 10.24843/jfu.2023.v12.i01.p07
Fiqri Zulpadly, S. Rahayu
Dalam pelaksanaan tugas pengelolaan sediaan farmasi dan bahan medis habis pakai (BMHP), Puskesmas perlu melakukan manajemen Puskesmas secara efektif dan efisien. Salah satu kegiatannya adalah manajemen inventaris farmasi. Pada penelitian ini dilakukan analisis ABC dalam perencanaan pengadaan sediaan farmasi dan BMHP di Puskesmas Gamping I Yogyakarta Periode Januari-Desember 2021. Tujuannya adalah untuk mengetahui pengelompokkan item secara ABC berdasarkan nilai investasi serta proporsi persentase setiap kelompok sediaan farmasi dan BMHP di Puskesmas. Jenis penelitian ini adalah penelitian non eksperimental dengan analisis secara deskriptif menggunakan data kuantitatif yang dilakukan secara retrospektif. Data primer diperoleh melalui wawancara dengan apoteker unit farmasi Puskesmas, sedangkan data sekunder bersumber dari riwayat pengadaan sediaan farmasi dan BMHP berdasarkan LPLPO Puskesmas tersebut selama periode Januari-Desember 2021. Hasil menunjukkan bahwa untuk kategori sediaan farmasi, sebesar 0,73% item dari jumlah keseluruhan termasuk dalam kelompok A. Kelompok B terdiri dari 9 item dan kelompok C 127 item. Untuk BMHP, persentase kelompok A adalah sebesar 16,67% dari total persediaan yang berjumlah 54 item. Kelompok B dengan persentase 22,22% dan kelompok C 61,11%. Kata kunci: Analisis ABC, perencanaan pengadaan
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