Background and Objectives The prevalence of hearing loss in infants with a risk factor is higher than in infants without a risk factor. The aim of this work is determine the prevalence of hearing loss and identify the most significant risk factors for hearing impairment in neonates hospitalized at neonates unit. Subjects and Methods A total of 450 infants admitted to the neonatal unit of Abuzar hospital in Ahvaz were evaluated for hearing in October 2020 to April 2020. The hearing screening tests performed were Transient Evoked Otoacoustic Emissions (TEOAES) and the automated auditory brain stem response (AABR). Risk factors include birth weight less than 1500g, prematurity, family history of hearing loss, consanguineous marriage, hyperbilirubinemia, mechanical ventilation for more than 5 days, asphyxia, autotoxic drugs, sepsis, hypoglycemia and Apgar less than 5 were in one minute after birth. Results twenty neonates (4.4%) had different type of hearing loss. Mechanical Ventilation more than 5 days, sepsis, asphyxia, hyperbilirubinemia and Apgar<5 were considered risk factors of hearing loss. Conclusion The prevalence of hearing loss in neonate with risk factor is significant that raises the need for hearing screening using TEOAE and AABR simultaneously. It is recommended that children with hearing loss risk factors be evaluated for hearing periodically.
{"title":"Determining the Frequency of Hearing Loss and Its Risk Factors in Neonates Admitted to the Neonatal Unit: A Hospital Study","authors":"M. Delfi, Elena Goodarzi, A. Hardani, G. Badfar","doi":"10.32598/jsmj.20.5.2305","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2305","url":null,"abstract":"Background and Objectives The prevalence of hearing loss in infants with a risk factor is higher than in infants without a risk factor. The aim of this work is determine the prevalence of hearing loss and identify the most significant risk factors for hearing impairment in neonates hospitalized at neonates unit. Subjects and Methods A total of 450 infants admitted to the neonatal unit of Abuzar hospital in Ahvaz were evaluated for hearing in October 2020 to April 2020. The hearing screening tests performed were Transient Evoked Otoacoustic Emissions (TEOAES) and the automated auditory brain stem response (AABR). Risk factors include birth weight less than 1500g, prematurity, family history of hearing loss, consanguineous marriage, hyperbilirubinemia, mechanical ventilation for more than 5 days, asphyxia, autotoxic drugs, sepsis, hypoglycemia and Apgar less than 5 were in one minute after birth. Results twenty neonates (4.4%) had different type of hearing loss. Mechanical Ventilation more than 5 days, sepsis, asphyxia, hyperbilirubinemia and Apgar<5 were considered risk factors of hearing loss. Conclusion The prevalence of hearing loss in neonate with risk factor is significant that raises the need for hearing screening using TEOAE and AABR simultaneously. It is recommended that children with hearing loss risk factors be evaluated for hearing periodically.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86052422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Mohammadkhani, H. Rajabi, N. Khaledi, A. Komaki, I. Salehi
Background and Objectives The fetal period is an important stage in a person’s life. Exercise during pregnancy has been considered as a positive factor in preventing chronic diseases in adulthood. The aim of this study was to investigate the role of maternal high intensity exercise before and during pregnancy on serum levels of lipid profile of adult offspring. Subjects and Methods Twenty-four rats (170-200g) were divided into three maternal groups: Control (C), exercise Before Pregnancy (BP) and exercise before and during pregnancy (BDP). Exercise performed before pregnancy for six weeks and during pregnancy for three weeks; one minute with 80% -95% vo2max switching with two minutes of active recovery (65% vo2max) for five days/week. After end of the training birth process and breastfeeding, the offspring were divided according to theirs’s mother group and they were kept until adult age. The serum levels of LDL, HDL, TG and Cho were measured by enzymic method. Results The one-way ANOVA result showed that maternal exercise before and during pregnancy significantly reduced LDL, Cho and LDL/HDL cholesterol ratio in male (P=0.03, P=0.2, P=0.04) and female (P=0.00, P=0.02, P=0.04) offspring. Conclusion This finding suggests that maternal high-intensity-interval training as an appropriate environmental intervention can help to improve the health of the next generation.
{"title":"Effect of Maternal Training Before and During Pregnancy on the Lipid Profile in Wistar Rat Offspring","authors":"R. Mohammadkhani, H. Rajabi, N. Khaledi, A. Komaki, I. Salehi","doi":"10.32598/jsmj.20.5.2131","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2131","url":null,"abstract":"Background and Objectives The fetal period is an important stage in a person’s life. Exercise during pregnancy has been considered as a positive factor in preventing chronic diseases in adulthood. The aim of this study was to investigate the role of maternal high intensity exercise before and during pregnancy on serum levels of lipid profile of adult offspring. Subjects and Methods Twenty-four rats (170-200g) were divided into three maternal groups: Control (C), exercise Before Pregnancy (BP) and exercise before and during pregnancy (BDP). Exercise performed before pregnancy for six weeks and during pregnancy for three weeks; one minute with 80% -95% vo2max switching with two minutes of active recovery (65% vo2max) for five days/week. After end of the training birth process and breastfeeding, the offspring were divided according to theirs’s mother group and they were kept until adult age. The serum levels of LDL, HDL, TG and Cho were measured by enzymic method. Results The one-way ANOVA result showed that maternal exercise before and during pregnancy significantly reduced LDL, Cho and LDL/HDL cholesterol ratio in male (P=0.03, P=0.2, P=0.04) and female (P=0.00, P=0.02, P=0.04) offspring. Conclusion This finding suggests that maternal high-intensity-interval training as an appropriate environmental intervention can help to improve the health of the next generation.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83911463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Momen, Shideh Asar, Maryam Heydar Azadeh, Ghasem Karimi
Background and Objectives Acute gastroenteritis is a highly prevalent disease in children. Various factors may causes seizure in children with gastroenteritis. This study was designed to determine the frequency, clinical characteristics and causes of seizure in children younger than 5 years with acute gastroenteritis admitted to Ahvaz Golestan hospital. Subjects and Methods In a retrospective descriptive study based on hospital records , 339 children under 5 years old who were admitted to Ahvaz Golestan hospital during 2016 - 2017 were assessed. Patients with underlying neurological disorders were excluded and the recorded information of patients with seizure was reviewed. Results Out of 339 reviewed cases, 59 patients (17.4%) had seizures, most prevalent in13 to 24 months age group (28.8%). In 74.6% of cases, type of diarrhea were dysentery. 64.4% had mild dehydration. Encephalopathy was detected in 1.7%, shigellosis in 6.8%, hyponatremia in 32.2% and hypernatremia in 3.4%. Seizures in 52.5% of cases were considered as febrile Seizure. Diagnostic criteria of benign convulsions associated with mild gastroenteritis (CwG) were present in 5% of patients. 79.7% of cases had generalized seizures. In comparison, a significant relationship was observed between the febrile and non-febrile groups only in the variable of diarrhea type. Conclusion The results show that fever and electrolyte imbalances and among infectious agents, Shigella are important causes of seizures in patients with gastroenteritis. In patients with dysentery, seizures are more likely.
{"title":"Survey of Frequency, Clinical Characteristics and Causes of Seizure in Children Younger Than Five Years With Acute Gastroenteritis Admitted to Ahvaz Golestan Hospital Over a Two Year Period","authors":"A. Momen, Shideh Asar, Maryam Heydar Azadeh, Ghasem Karimi","doi":"10.32598/jsmj.20.5.2197","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2197","url":null,"abstract":"Background and Objectives Acute gastroenteritis is a highly prevalent disease in children. Various factors may causes seizure in children with gastroenteritis. This study was designed to determine the frequency, clinical characteristics and causes of seizure in children younger than 5 years with acute gastroenteritis admitted to Ahvaz Golestan hospital. Subjects and Methods In a retrospective descriptive study based on hospital records , 339 children under 5 years old who were admitted to Ahvaz Golestan hospital during 2016 - 2017 were assessed. Patients with underlying neurological disorders were excluded and the recorded information of patients with seizure was reviewed. Results Out of 339 reviewed cases, 59 patients (17.4%) had seizures, most prevalent in13 to 24 months age group (28.8%). In 74.6% of cases, type of diarrhea were dysentery. 64.4% had mild dehydration. Encephalopathy was detected in 1.7%, shigellosis in 6.8%, hyponatremia in 32.2% and hypernatremia in 3.4%. Seizures in 52.5% of cases were considered as febrile Seizure. Diagnostic criteria of benign convulsions associated with mild gastroenteritis (CwG) were present in 5% of patients. 79.7% of cases had generalized seizures. In comparison, a significant relationship was observed between the febrile and non-febrile groups only in the variable of diarrhea type. Conclusion The results show that fever and electrolyte imbalances and among infectious agents, Shigella are important causes of seizures in patients with gastroenteritis. In patients with dysentery, seizures are more likely.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81837726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mirzavand, M. Beiromvand, A. Rafiei, A. Bahreini, Bahman. Cheraghiyan, A. Motamedfar, Alireza Abdolhadi Jahanshahi
Background and Objectives Hydatid cyst is a worldwide zoonotic disease caused by the larval stages of Echinococcus granulosus. The aim of this study was to investigate the demographic, clinical and radiological characteristics of hydatidosis patients undergoing surgery in hospitals in Ahvaz during Subjects and Methods This study is a retrospective descriptive cross-sectional study based on the information recorded in the patients' files. Data were analyzed using SPSS software, descriptive statistics and Chi-square test. Results Of the 107 patients with a mean age of 36.78 years, 42.1% were male and 57.9% were female. The highest frequency was related to the age group of 31-40 and the lowest was related to the patients under 10 years old. 52.3% lived in the rural areas and 47.7% lived in the urban areas. In 70.1% of the patients, liver was involved and recurrence was reported in 14%. In 59.8% of the patients, only one cyst was reported and in 40.2% more than one cyst was reported. The cysts size was 10 to 180 mm and about 50% of the patients had CE2 cysts. The diagnostic method of all patients was imaging techniques and drainage method was the most common method used. Conclusion This study showed that hydatid cyst in Khuzestan Province is still one of the important health problems that raise the need for educational programs based on the prevention and control of parasitic infections, especially parasites transmitted by dogs. Observation of 14% recurrence also raises the importance of choosing the appropriate surgical method by surgeons.
{"title":"Demographic, Clinical, and Radiological Characteristics of Patients With Hydatid Cyst Refereed to Ahvaz Hospitals During 2017-2019","authors":"S. Mirzavand, M. Beiromvand, A. Rafiei, A. Bahreini, Bahman. Cheraghiyan, A. Motamedfar, Alireza Abdolhadi Jahanshahi","doi":"10.32598/jsmj.20.5.2516","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2516","url":null,"abstract":"Background and Objectives Hydatid cyst is a worldwide zoonotic disease caused by the larval stages of Echinococcus granulosus. The aim of this study was to investigate the demographic, clinical and radiological characteristics of hydatidosis patients undergoing surgery in hospitals in Ahvaz during Subjects and Methods This study is a retrospective descriptive cross-sectional study based on the information recorded in the patients' files. Data were analyzed using SPSS software, descriptive statistics and Chi-square test. Results Of the 107 patients with a mean age of 36.78 years, 42.1% were male and 57.9% were female. The highest frequency was related to the age group of 31-40 and the lowest was related to the patients under 10 years old. 52.3% lived in the rural areas and 47.7% lived in the urban areas. In 70.1% of the patients, liver was involved and recurrence was reported in 14%. In 59.8% of the patients, only one cyst was reported and in 40.2% more than one cyst was reported. The cysts size was 10 to 180 mm and about 50% of the patients had CE2 cysts. The diagnostic method of all patients was imaging techniques and drainage method was the most common method used. Conclusion This study showed that hydatid cyst in Khuzestan Province is still one of the important health problems that raise the need for educational programs based on the prevention and control of parasitic infections, especially parasites transmitted by dogs. Observation of 14% recurrence also raises the importance of choosing the appropriate surgical method by surgeons.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88033298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saeed Rahimi Ahmad Baladi, V. Tadibi, Sedigheh Hosseeinpoor Delavar, E. Amiri, M. Jalilvand
Background and Aim: Military personnel are exposed to some work stress due to their working conditions, which causes negative effects on their quality of life. The aim of this study was to investigate the effect of sixteen weeks of functional training on quality of life and mental health of military personnel. Research method: In the present Quasi-experimental research, 150 military personnel from Andimeshk and Dezfoul sities were selected by random sampling method and divided in two training and control groups. Exercise was performed for sixteen weeks of functional training, three sessions per week, and each training session lasted about 60-90 minutes. T-test was used for statistical analysis. Results: After the training period, there was a significant improvement in the quality of life sub-comparisons of physical function, physical role, emotional role, energy and vitality, social function, physical pain, and general health in the functional training group compared to the control group, but the difference No significance was observed in cognitive health between the two groups. In the subscales of mental health, a significant improvement in physical symptoms, anxiety symptoms and sleep and social dysfunction was observed in the functional exercise group compared to the control group, but a significant difference in changes in depressive symptoms was observed in the functional exercise group compared to the control group. Failed. Discussion and Conclusion: According to the findings of the present study, it can be said that functional exercises have improved the quality of life of military personnel by improving their mental health.
{"title":"The effect of sixteen weeks of functional training on quality of life and mental health in military personnel","authors":"Saeed Rahimi Ahmad Baladi, V. Tadibi, Sedigheh Hosseeinpoor Delavar, E. Amiri, M. Jalilvand","doi":"10.32598/jsmj.20.5.2234","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2234","url":null,"abstract":"Background and Aim: Military personnel are exposed to some work stress due to their working conditions, which causes negative effects on their quality of life. The aim of this study was to investigate the effect of sixteen weeks of functional training on quality of life and mental health of military personnel. Research method: In the present Quasi-experimental research, 150 military personnel from Andimeshk and Dezfoul sities were selected by random sampling method and divided in two training and control groups. Exercise was performed for sixteen weeks of functional training, three sessions per week, and each training session lasted about 60-90 minutes. T-test was used for statistical analysis. Results: After the training period, there was a significant improvement in the quality of life sub-comparisons of physical function, physical role, emotional role, energy and vitality, social function, physical pain, and general health in the functional training group compared to the control group, but the difference No significance was observed in cognitive health between the two groups. In the subscales of mental health, a significant improvement in physical symptoms, anxiety symptoms and sleep and social dysfunction was observed in the functional exercise group compared to the control group, but a significant difference in changes in depressive symptoms was observed in the functional exercise group compared to the control group. Failed. Discussion and Conclusion: According to the findings of the present study, it can be said that functional exercises have improved the quality of life of military personnel by improving their mental health.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79730030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Infection of the blood and cerebrospinal fluid can have irreparable consequences and even death. In the present study, the prevalence of bacteria causing blood and cerebrospinal fluid infection and their antibiotic resistance in hospitalized patients was investigated. Materials and Methods: In this present descriptive-cross-sectional study, the results of all blood and cerebrospinal fluid samples were sent for culture from the hospitalized patients of Golestan Hospital in Ahvaz in the first six months of 2019 were examined. Relevant information was extracted from patients' medical records. Results: In this study, 12.17% of blood culture were positive and 7.6% of cerebrospinal fluid culture were positive. The most common bacteria causing blood infections were Staphylococcus Coagulase Negative (32.5%), Klebsiella (24.1%) and Pseudomonas (21.7%), and the most common bacteria causing cerebrospinal fluid infection were Klebsiella (30.9%), Streptococcus. group D (Enterococcus) (20.6%) and pseudomonas (15.5%). The highest bacterial resistance was observed for Ampicillin, Ceftriaxone, Cefazolin, Cefixime and Cefotaxime antibiotics, and the highest sensitivity was observed for Meropenem, Colistin, and Levofloxacin antibiotics. Conclusion: Since the bacterial resistance pattern is always changing, it is suggested that before starting any empirical treatment in infectious diseases, sensitive antibiotics for common bacterial agents are recommended for a more efficient treatment.
{"title":"Evaluation of Blood and CSF Isolated Bacteria and Their Antimicrobial Resistance in Hospitalized Patients in Ahvaz Golestan Hospital in 1398","authors":"Ladan Fatahi, saeed Eyn Ali Varnosefadrani","doi":"10.32598/jsmj.20.5.2116","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2116","url":null,"abstract":"Introduction: Infection of the blood and cerebrospinal fluid can have irreparable consequences and even death. In the present study, the prevalence of bacteria causing blood and cerebrospinal fluid infection and their antibiotic resistance in hospitalized patients was investigated. Materials and Methods: In this present descriptive-cross-sectional study, the results of all blood and cerebrospinal fluid samples were sent for culture from the hospitalized patients of Golestan Hospital in Ahvaz in the first six months of 2019 were examined. Relevant information was extracted from patients' medical records. Results: In this study, 12.17% of blood culture were positive and 7.6% of cerebrospinal fluid culture were positive. The most common bacteria causing blood infections were Staphylococcus Coagulase Negative (32.5%), Klebsiella (24.1%) and Pseudomonas (21.7%), and the most common bacteria causing cerebrospinal fluid infection were Klebsiella (30.9%), Streptococcus. group D (Enterococcus) (20.6%) and pseudomonas (15.5%). The highest bacterial resistance was observed for Ampicillin, Ceftriaxone, Cefazolin, Cefixime and Cefotaxime antibiotics, and the highest sensitivity was observed for Meropenem, Colistin, and Levofloxacin antibiotics. Conclusion: Since the bacterial resistance pattern is always changing, it is suggested that before starting any empirical treatment in infectious diseases, sensitive antibiotics for common bacterial agents are recommended for a more efficient treatment.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"16 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91446651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Golpasand Hagh, Azarnoosh Ariankia, H. Shahbazian
Background and Objectives Most renal patients have various oral manifestations such as halitosis, xerostomia and pale mucosa. The purpose of this study was to evaluate the relationship between periodontal status and chronic renal disease. Subjects and Methods In this case-control study, the case group was divided into three subgroups, which included renal patients before dialysis, patients undergoing hemodialysis, and patients after renal transplantation, each of which included 23 patients. The control group also included 38 healthy individuals in terms of renal function. After obtaining the consent form and completing the questionnaire, the amount of plaque index, gingival index, papillary bleeding index, probing depth, loss of clinical attachment, gingival recession and gingival enlargement were measured T-student,chi-square. and Anova was used to analyze the data. Results The plaque index, gingival index, papillary bleeding index, probing depth, loss of clinical attachment in groups with chronic renal disease were higher than the control groups (P< 0.001) but there was no significant difference in gingival recession and gingival enlargement between control group and case groups (P> 0.05 ) . These parameters were not significantly different between the groups with chronic renal disease (P> 0.05). Conclusion Periodontal disease is more common in patients with chronic renal disease, therefore, special periodontal treatment considerations and regular dental examinations should be added to the treatment plan of these patients.
{"title":"Evaluation of Periodontal Status in Patients With Chronic Renal Disease","authors":"L. Golpasand Hagh, Azarnoosh Ariankia, H. Shahbazian","doi":"10.32598/jsmj.20.5.2679","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2679","url":null,"abstract":"Background and Objectives Most renal patients have various oral manifestations such as halitosis, xerostomia and pale mucosa. The purpose of this study was to evaluate the relationship between periodontal status and chronic renal disease. Subjects and Methods In this case-control study, the case group was divided into three subgroups, which included renal patients before dialysis, patients undergoing hemodialysis, and patients after renal transplantation, each of which included 23 patients. The control group also included 38 healthy individuals in terms of renal function. After obtaining the consent form and completing the questionnaire, the amount of plaque index, gingival index, papillary bleeding index, probing depth, loss of clinical attachment, gingival recession and gingival enlargement were measured T-student,chi-square. and Anova was used to analyze the data. Results The plaque index, gingival index, papillary bleeding index, probing depth, loss of clinical attachment in groups with chronic renal disease were higher than the control groups (P< 0.001) but there was no significant difference in gingival recession and gingival enlargement between control group and case groups (P> 0.05 ) . These parameters were not significantly different between the groups with chronic renal disease (P> 0.05). Conclusion Periodontal disease is more common in patients with chronic renal disease, therefore, special periodontal treatment considerations and regular dental examinations should be added to the treatment plan of these patients.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88164614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
faranak daneshi, F. Ghorbani, golnaz asadi tehrani, azadeh mirza ahmadi
Background and Aim:Leukemia usually begins in the bone marrow and leads to the production of a large number of abnormal white blood cells.The goal of this study was to investigate changes on UCA1 lncRNA and AKT target, gene expression alternations, regulating PI3K/ AKT signaling pathway in Jurkat E6.1 Acute Lympholastic Leukemia cell line under treatment with thiosemicarbazone complexes(nickel). Materials and Methods: First, thiosemicarbazones complex Ni and 6MP was provided in different concentrations(0.5,1,2,5macromolecular)and(1,5,10,25macromolecular) and the jurkat E.6.1 Cancer cells were treated with mentioned doses at (24-48-72hours)after cell passage. Next RNA extraction and cDNA synthesis were performed and the expression of UCA1 and AKT gene were appraised by Real Time PCR. Finally, the results were analyzed by Rest Software. Results:UCA1 showed a significant decrease during 24hours of treatment with 6mp at concentrations(1,5,10and25macromolecular)(P<0.001).In nickel,a significant decrease at 72hours was observed at concentrations(2and 5macromolecular).in the AKT in treatment with 6mp at 24hours At concentrations(5,10and 25macromolecular)And all concentrations(1,5,10and25macromolecular)at 72hours showed a significant decrease(P<0.001).In nickel at concentrations(0.5,1,2and5macromolecular)at 24hours Decreased expression was observed,This decrease is not statistically significant at a concentration of 0.5μM.at concentrations(2and 5macromolecular)Significant reductions at 48and72hours were observed(P<0.001). Conclusion:UCA1 and AKT expression changes after treatment with 6mp and nickel depend on drug timing and concentration.UCA1 in 6MP treatment at 25μM and 24hours,in treatment with nickel at 5μM and 72hours , AKT in 6mp treatment at 25μM and 72hours , In treatment with nickel at 5μM and 24hours,It had the highest effect on the cell due to gene expression.
{"title":"Analysis of thiosemi carbazon complexes effects on UCA1 lncRNA and AKT target, gene expression alternations, regulating PI3K/ AKT signaling pathway in Jurkat E6.1 Acute Lympholastic Leukemia cell line","authors":"faranak daneshi, F. Ghorbani, golnaz asadi tehrani, azadeh mirza ahmadi","doi":"10.32598/jsmj.20.5.2194","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2194","url":null,"abstract":"Background and Aim:Leukemia usually begins in the bone marrow and leads to the production of a large number of abnormal white blood cells.The goal of this study was to investigate changes on UCA1 lncRNA and AKT target, gene expression alternations, regulating PI3K/ AKT signaling pathway in Jurkat E6.1 Acute Lympholastic Leukemia cell line under treatment with thiosemicarbazone complexes(nickel). Materials and Methods: First, thiosemicarbazones complex Ni and 6MP was provided in different concentrations(0.5,1,2,5macromolecular)and(1,5,10,25macromolecular) and the jurkat E.6.1 Cancer cells were treated with mentioned doses at (24-48-72hours)after cell passage. Next RNA extraction and cDNA synthesis were performed and the expression of UCA1 and AKT gene were appraised by Real Time PCR. Finally, the results were analyzed by Rest Software. Results:UCA1 showed a significant decrease during 24hours of treatment with 6mp at concentrations(1,5,10and25macromolecular)(P<0.001).In nickel,a significant decrease at 72hours was observed at concentrations(2and 5macromolecular).in the AKT in treatment with 6mp at 24hours At concentrations(5,10and 25macromolecular)And all concentrations(1,5,10and25macromolecular)at 72hours showed a significant decrease(P<0.001).In nickel at concentrations(0.5,1,2and5macromolecular)at 24hours Decreased expression was observed,This decrease is not statistically significant at a concentration of 0.5μM.at concentrations(2and 5macromolecular)Significant reductions at 48and72hours were observed(P<0.001). Conclusion:UCA1 and AKT expression changes after treatment with 6mp and nickel depend on drug timing and concentration.UCA1 in 6MP treatment at 25μM and 24hours,in treatment with nickel at 5μM and 72hours , AKT in 6mp treatment at 25μM and 72hours , In treatment with nickel at 5μM and 24hours,It had the highest effect on the cell due to gene expression.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88872824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives The use of antioxidant supplements improves and reduces oxidative stress factors following intense intense exercise. Exhaustion was performed in female athletes. Subjects and Methods 14 female athletes with an age range of 20 to 28 years and a maximum oxygen consumption of 42-52 m/kg/min in a quasi-experimental design randomly divided into two groups receiving coenzyme Q10 supplementation and placebo (5 mg/kg body weight). Were. After 14 days of coenzyme Q10 supplementation, the subjects performed an intense, debilitating activity. Urine samples were collected in three stages (baseline, before and 24 hours after exhaustive activity) to determine the concentration of 8-OHdG and MDA. Results There was a significant difference of 62% in the increasing response of urinaryOHdG-8 to an exhausting aerobic exercise session (P = 0.003). However, the 2% difference in the increasing urinary MDA response of the supplement and placebo groups was not significant after the last quasi-competitive aerobic training session (P = 0.7). Conclusion According to the results of the study, two weeks of high-pressure aerobic training causes DNA damage and lipid peroxidation in female athletes, and supplementation with Q10 helps prevent the 8-OHdG response of female athletes after a strenuous high-pressure aerobic training session and reduces DNA damage. Become athlete
{"title":"The Effect of Q10 Supplementation on Lipid and DNA Degradation Indices Following an Acute Physical Activity","authors":"Babak Bazeh, Afshar Jafari, A. Malekirad","doi":"10.32598/jsmj.20.5.2508","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2508","url":null,"abstract":"Background and Objectives The use of antioxidant supplements improves and reduces oxidative stress factors following intense intense exercise. Exhaustion was performed in female athletes. Subjects and Methods 14 female athletes with an age range of 20 to 28 years and a maximum oxygen consumption of 42-52 m/kg/min in a quasi-experimental design randomly divided into two groups receiving coenzyme Q10 supplementation and placebo (5 mg/kg body weight). Were. After 14 days of coenzyme Q10 supplementation, the subjects performed an intense, debilitating activity. Urine samples were collected in three stages (baseline, before and 24 hours after exhaustive activity) to determine the concentration of 8-OHdG and MDA. Results There was a significant difference of 62% in the increasing response of urinaryOHdG-8 to an exhausting aerobic exercise session (P = 0.003). However, the 2% difference in the increasing urinary MDA response of the supplement and placebo groups was not significant after the last quasi-competitive aerobic training session (P = 0.7). Conclusion According to the results of the study, two weeks of high-pressure aerobic training causes DNA damage and lipid peroxidation in female athletes, and supplementation with Q10 helps prevent the 8-OHdG response of female athletes after a strenuous high-pressure aerobic training session and reduces DNA damage. Become athlete","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89014352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamadhassan Olamazadeh, G. Sharifi, M. Gharipour, Masoumeh Sadeghi, Elham Khosravi, Shiva Olamazadeh, Ladan Sadeghian, A. Ahmadi
Background: Acute myocardial infarction refers to a reduction or amputation of coronary artery circulation leading to myocardial necrosis. BDNF is expressed in atherosclerotic arteries, vascular smooth muscle, and endothelial cells and is involved in angiogenesis, the inflammatory response, and apoptosis of myocardial regeneration after infarction. The aim of this study was to evaluate the effect of a cardiac rehabilitation period on changes in BDNF levels and functional capacity in patients with acute myocardial infarction. Methods: The present study was performed on 30 men with acute coronary syndrome with a pretest-posttest design and the samples were randomly divided into experimental and control groups. The experimental group performed a cardiac rehabilitation program for 6 weeks. The control group did not perform any training during this period. Before and after the rehabilitation program, BDNF levels were measured by the American Diaplus Kit in terms of picograms per milliliter and participants' functional capacity by a modified Bruce test. Analysis of covariance was used to compare BDNF levels and functional capacity of cardiac rehabilitation and control groups. Discussion & Conclusion: Data were analyzed by covariance and the results showed that cardiac rehabilitation training had a significant effect on increasing BDNF levels and functional capacity (P≤0.05). In general, it can be said that cardiac rehabilitation exercise program can play an important role in improving the physical and physiological condition of patients with acute myocardial infarction.
{"title":"The impact of a cardiac rehabilitation course on BDNF level changes and functional capacity in acute myocardial infarction patients","authors":"Mohamadhassan Olamazadeh, G. Sharifi, M. Gharipour, Masoumeh Sadeghi, Elham Khosravi, Shiva Olamazadeh, Ladan Sadeghian, A. Ahmadi","doi":"10.32598/jsmj.20.5.2244","DOIUrl":"https://doi.org/10.32598/jsmj.20.5.2244","url":null,"abstract":"Background: Acute myocardial infarction refers to a reduction or amputation of coronary artery circulation leading to myocardial necrosis. BDNF is expressed in atherosclerotic arteries, vascular smooth muscle, and endothelial cells and is involved in angiogenesis, the inflammatory response, and apoptosis of myocardial regeneration after infarction. The aim of this study was to evaluate the effect of a cardiac rehabilitation period on changes in BDNF levels and functional capacity in patients with acute myocardial infarction. Methods: The present study was performed on 30 men with acute coronary syndrome with a pretest-posttest design and the samples were randomly divided into experimental and control groups. The experimental group performed a cardiac rehabilitation program for 6 weeks. The control group did not perform any training during this period. Before and after the rehabilitation program, BDNF levels were measured by the American Diaplus Kit in terms of picograms per milliliter and participants' functional capacity by a modified Bruce test. Analysis of covariance was used to compare BDNF levels and functional capacity of cardiac rehabilitation and control groups. Discussion & Conclusion: Data were analyzed by covariance and the results showed that cardiac rehabilitation training had a significant effect on increasing BDNF levels and functional capacity (P≤0.05). In general, it can be said that cardiac rehabilitation exercise program can play an important role in improving the physical and physiological condition of patients with acute myocardial infarction.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78531287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：