S. Geravandi, M. Dastoorpour, G. Goudarzi, F. Karimi, M. Mohammadi
Background and Objectives Optimal physical space and mental environment are the most important factors in achieving the good level of educational quality. A healthy environment and a safety education play an important role to prevent diseases and accidents. The aim of this study was to determine the safety and environmental health condition of Andika city schools and its comparison with national standards. Subjects and Methods This is a descriptive cross-sectional study in which 40 schools from all Andika city schools. In this study, first Raw data processing by the use of Excel software (instruction set correction of temperature and pressure, averaging, coding). In final stage estimated of the safety and environmental health condition of Andika city schools with used data processed. Results Based on result, 77.8% of urban and 80.6% of rural schools had access to safe drinking water. In 55.6% of urban schools and 22.6% of standard rural schools the number of abutments was observed. The minimum required area per student is met in 100% of urban schools and 83.9% of rural areas. According to result this study, in 77.8% of urban schools and 35.5% of standard rural schools the number of toilets was observed. The standard of toilets was observed in 44.4% of urban and 29% of rural schools. In 44.4% of urban schools and 35.5% of rural schools, wastewater disposal methods were used according to health standards. Resul of study showed that 44.4% of urban schools and 74.2% of rural schools had health conditions. Conclusion Findings showed that the safety and environmental health condition of schools has an effective role in efficiency and raising the level of education.
{"title":"A Survey Study on Safety and Environmental Health Condition of Andika City Schools","authors":"S. Geravandi, M. Dastoorpour, G. Goudarzi, F. Karimi, M. Mohammadi","doi":"10.32598/jsmj.20.4.2275","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2275","url":null,"abstract":"Background and Objectives Optimal physical space and mental environment are the most important factors in achieving the good level of educational quality. A healthy environment and a safety education play an important role to prevent diseases and accidents. The aim of this study was to determine the safety and environmental health condition of Andika city schools and its comparison with national standards. Subjects and Methods This is a descriptive cross-sectional study in which 40 schools from all Andika city schools. In this study, first Raw data processing by the use of Excel software (instruction set correction of temperature and pressure, averaging, coding). In final stage estimated of the safety and environmental health condition of Andika city schools with used data processed. Results Based on result, 77.8% of urban and 80.6% of rural schools had access to safe drinking water. In 55.6% of urban schools and 22.6% of standard rural schools the number of abutments was observed. The minimum required area per student is met in 100% of urban schools and 83.9% of rural areas. According to result this study, in 77.8% of urban schools and 35.5% of standard rural schools the number of toilets was observed. The standard of toilets was observed in 44.4% of urban and 29% of rural schools. In 44.4% of urban schools and 35.5% of rural schools, wastewater disposal methods were used according to health standards. Resul of study showed that 44.4% of urban schools and 74.2% of rural schools had health conditions. Conclusion Findings showed that the safety and environmental health condition of schools has an effective role in efficiency and raising the level of education.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"2675 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73879828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ghalavand, H. Saki, F. Nazem, Nasim Khademitab, Hafez Behzadi nezhad, Mohsen Behbodi, F. Zeighami
Background and Objectives Type 1 diabetes is one of the most common chronic diseases in children. The aim of this study was to determine the effect of eight weeks of regular exercise training and Ganoderma supplementation on glycemic control in children with type 1 diabetes. Subjects and Methods In this quasi-experimental study, 40 boys with type 1 diabetes were selected and divided into 4 groups: 1) exercise, 2) supplement, 3) exercise & supplement 4) control. Exercises included 8 weeks, 3 sessions per week and each training session included selected exercises training. Ganoderma lucidum consumption for daily consumption of 20 grams of a brewed drink was consumed. Fasting blood sampling was performed 48 hours before and 72 hours after the intervention. Results A significant decrease was observed in 2Hour Post Prandial Glucose in the exercise & supplement group compared to the control group (P=0.018). Also Significant decrease was observed in HbA1c level in exercise (P=0.031) and exercise & supplement (P=0.043) compared to the control group. Conclusion According to the results, it can be said that combined exercise training can play an important role in the management of blood sugar in type 1 diabetes and the use of Ganoderma can increase the effectiveness of exercise in blood glycemic control along with exercise training.
{"title":"The Effect of Ganoderma Supplementation and Selected Exercise Training on Glycemic Control in Boys With Type 1 Diabetes","authors":"A. Ghalavand, H. Saki, F. Nazem, Nasim Khademitab, Hafez Behzadi nezhad, Mohsen Behbodi, F. Zeighami","doi":"10.32598/jsmj.20.4.2426","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2426","url":null,"abstract":"Background and Objectives Type 1 diabetes is one of the most common chronic diseases in children. The aim of this study was to determine the effect of eight weeks of regular exercise training and Ganoderma supplementation on glycemic control in children with type 1 diabetes. Subjects and Methods In this quasi-experimental study, 40 boys with type 1 diabetes were selected and divided into 4 groups: 1) exercise, 2) supplement, 3) exercise & supplement 4) control. Exercises included 8 weeks, 3 sessions per week and each training session included selected exercises training. Ganoderma lucidum consumption for daily consumption of 20 grams of a brewed drink was consumed. Fasting blood sampling was performed 48 hours before and 72 hours after the intervention. Results A significant decrease was observed in 2Hour Post Prandial Glucose in the exercise & supplement group compared to the control group (P=0.018). Also Significant decrease was observed in HbA1c level in exercise (P=0.031) and exercise & supplement (P=0.043) compared to the control group. Conclusion According to the results, it can be said that combined exercise training can play an important role in the management of blood sugar in type 1 diabetes and the use of Ganoderma can increase the effectiveness of exercise in blood glycemic control along with exercise training.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81913574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives The aim of this present study is to review the effects of antibacterial properties of oak fruit, inner husk of oak fruit, and Jaftex mouthwash. Subjects and Methods The present study is a narrative literature review conducted using electronic databases such as ISI, PubMed, Scopus, Google Scholar, SID, Magiran, and IranMedex from 1995 to 2019. The keywords that were searched included “Oak fruit”, “Oak tree”, “Jaftex mouthwash”, “Antibacterial”, “Antimicrobial”, and “Microorganism”. Results Review of previous studies showed that oak fruit, Jaft, and Jaftex mouthwash have antimicrobial properties against different microorganisms. Jaftex mouthwash significantly reduced number of microorganisms in mouth, however it had less antimicrobial effect compared to chlorhexidine. Jaftex had a greater inhibitory effect on bacterial growth than Matrica and Persica. Conclusion Oak fruit and Jaft have antibacterial properties which is related to presence of phenols, tannin, proteins. Various studies confirmed antibacterial property of these types of plants. The antibacterial characteristics of Jaftex mouthwash is mainly related to Jaft extract. Jaftex is recommended as an antibacterial mouthwash.
{"title":"Compression of Antibacterial Effect of Some Herbal Mouthwash Containing Oak Extract: Review Paper","authors":"Fatemeh Babadi, K. Rezaeifar","doi":"10.32598/jsmj.20.4.2190","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2190","url":null,"abstract":"Background and Objectives The aim of this present study is to review the effects of antibacterial properties of oak fruit, inner husk of oak fruit, and Jaftex mouthwash. Subjects and Methods The present study is a narrative literature review conducted using electronic databases such as ISI, PubMed, Scopus, Google Scholar, SID, Magiran, and IranMedex from 1995 to 2019. The keywords that were searched included “Oak fruit”, “Oak tree”, “Jaftex mouthwash”, “Antibacterial”, “Antimicrobial”, and “Microorganism”. Results Review of previous studies showed that oak fruit, Jaft, and Jaftex mouthwash have antimicrobial properties against different microorganisms. Jaftex mouthwash significantly reduced number of microorganisms in mouth, however it had less antimicrobial effect compared to chlorhexidine. Jaftex had a greater inhibitory effect on bacterial growth than Matrica and Persica. Conclusion Oak fruit and Jaft have antibacterial properties which is related to presence of phenols, tannin, proteins. Various studies confirmed antibacterial property of these types of plants. The antibacterial characteristics of Jaftex mouthwash is mainly related to Jaft extract. Jaftex is recommended as an antibacterial mouthwash.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90881456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Moghadam, Reza Rezaee Shirazi, Mohammad Shariatzadeh joneydi, Habib Asgharpour, M. Rahmati
Background and Objectives Diabetic neuropathy is one of the most common complications of diabetes and no suitable drug treatment has been found for this complication. The aim of this study was to determine the effect of six weeks of aerobic exercise on KIF1B protein in the sensory part of the spinal cord in rats with diabetic neuropathy. Subjects and Methods In the present experimental study, 12 male Wistar rats were divided into 4 groups: healthy exercise, control exercise, healthy diabetes and control diabetes. The training program included 6 weeks of running training on the treadmill in 5 sessions per week. The dorsal part of the spinal cord was analyzed as sensory neurons. Results The results showed that aerobic exercise significantly reduced blood glucose in the diabetic group compared to the control diabetes group (P=0.002), but no significant difference was observed in the weight of rats. The results also showed that a significant increase (P=0.044) in KIF1B in healthy exercise group compared to healthy control group and a significant increase (P=0.027) in KIF1B in diabetic exercise group compared to control diabetes. Conclusion The results showed that aerobic exercise increases the amount of KIF1B protein in healthy and diabetic rats, and this increase in KIF1B motor protein can improve axonal transmission and thus improve nerve function.
{"title":"Increased Levels of Spinal Cord KIF1B Protein In Healthy and Diabetic Neuropathic Wistar Rats With in Adaptation to Aerobic Training (KIF1B Changes in Sensory Neurons After Exercise)","authors":"Z. Moghadam, Reza Rezaee Shirazi, Mohammad Shariatzadeh joneydi, Habib Asgharpour, M. Rahmati","doi":"10.32598/jsmj.20.4.2424","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2424","url":null,"abstract":"Background and Objectives Diabetic neuropathy is one of the most common complications of diabetes and no suitable drug treatment has been found for this complication. The aim of this study was to determine the effect of six weeks of aerobic exercise on KIF1B protein in the sensory part of the spinal cord in rats with diabetic neuropathy. Subjects and Methods In the present experimental study, 12 male Wistar rats were divided into 4 groups: healthy exercise, control exercise, healthy diabetes and control diabetes. The training program included 6 weeks of running training on the treadmill in 5 sessions per week. The dorsal part of the spinal cord was analyzed as sensory neurons. Results The results showed that aerobic exercise significantly reduced blood glucose in the diabetic group compared to the control diabetes group (P=0.002), but no significant difference was observed in the weight of rats. The results also showed that a significant increase (P=0.044) in KIF1B in healthy exercise group compared to healthy control group and a significant increase (P=0.027) in KIF1B in diabetic exercise group compared to control diabetes. Conclusion The results showed that aerobic exercise increases the amount of KIF1B protein in healthy and diabetic rats, and this increase in KIF1B motor protein can improve axonal transmission and thus improve nerve function.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82222932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Internal Root Resorption (IRR) occurs in pulpchamber and canals of the tooth and results in desolation of around dentin. Regarding to important role of early diagnosis of IRR in prognose and treatment plan of the teeth and also limitations of intraoral technics in early detecting of these lesions, in this study we evaluated the accuracy of PSP in diagnosis of these lesions. Subjects and Methods We split 70 single root premolar teeth mesiodistalyand made artificial IRR in 35 teeth. The rest of them used as control group PSP and Conventional radiography captured from all teeth. IRR existence or not was considered in PSP and Conventionalradiographies of each tooth. Results PSP has complete agreement in all cases with reality but Conventional radiography in some cases particularly in 1/3 apical lesions of the root has moderate accuracy with reality and its results diden’t have considerable differences with reality. Conclusion Regarding to this study, has higher accuracy for PSP than Conventional radiography in detecting Internal root resorption lesions particularly in apical sites.
{"title":"Comparison of Diagnostic Accuracy of Conventional and Photo Stimulable- Phosphor Periapical Radiography in Internal Root Resorption Lesions","authors":"Sanaz Sharifi Shoshtari, Fatemeh Esfandiari","doi":"10.32598/jsmj.20.4.2277","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2277","url":null,"abstract":"Background and Objectives Internal Root Resorption (IRR) occurs in pulpchamber and canals of the tooth and results in desolation of around dentin. Regarding to important role of early diagnosis of IRR in prognose and treatment plan of the teeth and also limitations of intraoral technics in early detecting of these lesions, in this study we evaluated the accuracy of PSP in diagnosis of these lesions. Subjects and Methods We split 70 single root premolar teeth mesiodistalyand made artificial IRR in 35 teeth. The rest of them used as control group PSP and Conventional radiography captured from all teeth. IRR existence or not was considered in PSP and Conventionalradiographies of each tooth. Results PSP has complete agreement in all cases with reality but Conventional radiography in some cases particularly in 1/3 apical lesions of the root has moderate accuracy with reality and its results diden’t have considerable differences with reality. Conclusion Regarding to this study, has higher accuracy for PSP than Conventional radiography in detecting Internal root resorption lesions particularly in apical sites.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79286247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Cancer is the second leading cause of death in the world after cardiovascular disease, so the aim of the present study was to investigate phthalimide and naphthalimide derivatives in order to develop anticancer compounds. Subjects and Methods In this study, the cytotoxic activity of six phthalimed and naphthalamide derivatives was evaluated using MTT method on three cancerous cell lines, including breast cancer (MCF-7), ovarian cancer (SKOV3) and lung cancer (A549) cell line. Molecular Docking studies were also performed to determine the binding energy and the compounds interaction with DNA as a possible target of these compounds. Results Based on MTT results, compound C1, a naphthalimide derivative, showed the highest cytotoxic activity. IC50 values of this compound against MCF-7, SKOV3 and A549 cancer cell lines were 1.7, 6.2 and 9.5 μM, respectively. Also, comparison of phthalimide and naphthalimide derivatives showed that compounds C1, C3, C5 with carboxyl group had better effects than other compounds, C2, C6, C4, which bearing 5-amidoisophthalic acid moiety. Conclusion In general, naphthalimide derivatives showed better cytotoxicity than phthalimide derivatives. Compound C1 has the highest cytotoxic activity on all three cancer cell lines and can be further studied in the development of new anti-cancer compounds.
{"title":"Evaluation of Cytotoxicity and Molecular Docking Studies of Phthalimide and Naphthalimide Derivatives as Potential Anticancer Agents","authors":"Negin Ahanj, M. Taghavi, A. Mojaddami","doi":"10.32598/jsmj.20.4.2456","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2456","url":null,"abstract":"Background and Objectives Cancer is the second leading cause of death in the world after cardiovascular disease, so the aim of the present study was to investigate phthalimide and naphthalimide derivatives in order to develop anticancer compounds. Subjects and Methods In this study, the cytotoxic activity of six phthalimed and naphthalamide derivatives was evaluated using MTT method on three cancerous cell lines, including breast cancer (MCF-7), ovarian cancer (SKOV3) and lung cancer (A549) cell line. Molecular Docking studies were also performed to determine the binding energy and the compounds interaction with DNA as a possible target of these compounds. Results Based on MTT results, compound C1, a naphthalimide derivative, showed the highest cytotoxic activity. IC50 values of this compound against MCF-7, SKOV3 and A549 cancer cell lines were 1.7, 6.2 and 9.5 μM, respectively. Also, comparison of phthalimide and naphthalimide derivatives showed that compounds C1, C3, C5 with carboxyl group had better effects than other compounds, C2, C6, C4, which bearing 5-amidoisophthalic acid moiety. Conclusion In general, naphthalimide derivatives showed better cytotoxicity than phthalimide derivatives. Compound C1 has the highest cytotoxic activity on all three cancer cell lines and can be further studied in the development of new anti-cancer compounds.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78795125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives One of the ways to deal with Covid-19 disease is 19 preventive behaviors that seem to be affected by different factors. Therefore, the aim of the present study was to predict the preventive behaviors of Covid- 19 disease based on health literacy with the mediating role of media information belief and social responsibility. Subjects and Methods This descriptive and correlational study was performed on 247 adults in Ahvaz in the summer of 2020. The research sample was selected using available sampling and they answered online the questionnaires whose validity and reliability were confirmed.. Data were analyzed using Spss, Amose software, descriptive and analytical statistics. Results The results showed that the indirect coefficients between believing in media information (P=0.000, β=0.04) and social responsibility (P=0.000, β=0.11) with preventive behaviors of corona disease were significant. The proposed research model also had a good fit (RMSEA= 0.05, P=0.20, X2/df: 1.63, X2: 1.63). Conclusion The results showed that health literacy is both directly and indirectly related to corona disease prevention behaviors through belief in media information and social responsibility. Therefore, to increase the preventive behaviors of corona disease in individuals, we can use the influence of the media and strengthen social responsibility in individuals.
{"title":"Predicting Preventive Covid-19 Disease Behaviors Based on Health Literacy With the Mediating Role of Media and Social Responsibility in Adults Living in Ahvaz","authors":"Keyhan Fathi, Sara Shirmardi, K. Shiralinia","doi":"10.32598/jsmj.20.4.2619","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2619","url":null,"abstract":"Background and Objectives One of the ways to deal with Covid-19 disease is 19 preventive behaviors that seem to be affected by different factors. Therefore, the aim of the present study was to predict the preventive behaviors of Covid- 19 disease based on health literacy with the mediating role of media information belief and social responsibility. Subjects and Methods This descriptive and correlational study was performed on 247 adults in Ahvaz in the summer of 2020. The research sample was selected using available sampling and they answered online the questionnaires whose validity and reliability were confirmed.. Data were analyzed using Spss, Amose software, descriptive and analytical statistics. Results The results showed that the indirect coefficients between believing in media information (P=0.000, β=0.04) and social responsibility (P=0.000, β=0.11) with preventive behaviors of corona disease were significant. The proposed research model also had a good fit (RMSEA= 0.05, P=0.20, X2/df: 1.63, X2: 1.63). Conclusion The results showed that health literacy is both directly and indirectly related to corona disease prevention behaviors through belief in media information and social responsibility. Therefore, to increase the preventive behaviors of corona disease in individuals, we can use the influence of the media and strengthen social responsibility in individuals.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"214 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89175584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Dipeptidyl peptidase-4 inhibitors (DPP4-I) including sitagliptin is a new therapeutic class of oral anti-hyperglycemic drugs for T2DM. The aim of this study was to evaluate the frequency of glycemic control after adding sitagliptin on treatment regimen of patient with type 2 diabetic. Subjects and Methods This cross-sectional study conducted on 120 patients with type 2 diabetes mellitus referring to diabetes clinic of Imam Hospital, Ahvaz in 2019-2020. Sitagliptin (100 mg/day) was added to the preexisting therapy for type 2 diabetes (metformin / metformin + gliclazide / metformin + insulin). Therapeutic effects and glycemic control (Changes in the glycated hemoglobin (HbA1c) level) after 3 months of treatment were compared with the baseline. Results The result of this study showed that after 3 months of treatment the level of FBS, BS-2h and HbA1C in 3 groups were significantly reduced compared with before treatment (P<0.0001), but the patients weight in the three groups were not significantly changed (P=0.568). There was no significant difference in the frequency of glycemic control between the patients treated with different concomitant drugs (P=0.501). The results revealed that patients younger age (P=0.041), shorter disease duration (P=0.021) and with higher HbA1c levels at baseline (P<0.0001) were likely to show more decreased in HbA1c levels. Conclusion Our study shows that sitagliptin (in combination with different type of treatment regimens) has the potential to improve glycemic control and prevent hypoglycemia and weight gain, and can be considered a useful drug in patients with type 2 diabetes mellitus.
{"title":"The Frequency of Optimal Glycemic Control After Adding Sitagliptin on Treatment Regimen of Patient With Type 2 Diabetic","authors":"H. Rashidi, Fatemeh Boustani, A. Sedaghat","doi":"10.32598/jsmj.20.4.2324","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2324","url":null,"abstract":"Background and Objectives Dipeptidyl peptidase-4 inhibitors (DPP4-I) including sitagliptin is a new therapeutic class of oral anti-hyperglycemic drugs for T2DM. The aim of this study was to evaluate the frequency of glycemic control after adding sitagliptin on treatment regimen of patient with type 2 diabetic. Subjects and Methods This cross-sectional study conducted on 120 patients with type 2 diabetes mellitus referring to diabetes clinic of Imam Hospital, Ahvaz in 2019-2020. Sitagliptin (100 mg/day) was added to the preexisting therapy for type 2 diabetes (metformin / metformin + gliclazide / metformin + insulin). Therapeutic effects and glycemic control (Changes in the glycated hemoglobin (HbA1c) level) after 3 months of treatment were compared with the baseline. Results The result of this study showed that after 3 months of treatment the level of FBS, BS-2h and HbA1C in 3 groups were significantly reduced compared with before treatment (P<0.0001), but the patients weight in the three groups were not significantly changed (P=0.568). There was no significant difference in the frequency of glycemic control between the patients treated with different concomitant drugs (P=0.501). The results revealed that patients younger age (P=0.041), shorter disease duration (P=0.021) and with higher HbA1c levels at baseline (P<0.0001) were likely to show more decreased in HbA1c levels. Conclusion Our study shows that sitagliptin (in combination with different type of treatment regimens) has the potential to improve glycemic control and prevent hypoglycemia and weight gain, and can be considered a useful drug in patients with type 2 diabetes mellitus.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84106252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Objectives Chronic Kidney Disease (CKD) is characterized by progressive and irreversible loss of renal function. One of the complications of this disease is muscle wasting and atrophy. The aim of this study was to determine the effect of exercise training on CKD-induced muscle apoptosis in rats. Subjects and Methods In the present developmental study, 30 rats were selected and divided into 3 groups: disease training, disease control and healthy controls. Induction of CKD was through primary and final 1.3 resection of one kidney and complete resection of the other kidney. The training program consisted of eight weeks of continuous running training with an intensity of 45-55% VO2max. After removal of EDL muscle, protein level and Bcl-2 and Bax gene expression were measured by immunohistochemistry and real-time PCR, respectively. Results Induction of CKD caused a significant increase in protein level and gene expression of Bax and Bax/Bcl-2 and a significant decrease in Bcl-2 compared to the healthy control group (P<0.001). Also significant decrease was funded in the expression of genes and proteins Bax and Bax/Bcl-2 (P<0.001) and a significant increase was funded in protein Bcl-2 (P<0.001), without significant changes in the gene expression of Bcl-2 (P=0.935) in disease training compared to the disease control. Conclusion The results of the present study support the anti-apoptotic effect of exercise on muscle tissue of CKD patients; therefore, it is recommended that clinical research be conducted in this regard for exercise recommendations for these patients.
{"title":"The Effect of Chronic Kidney Disease Induction Upon Affective Factors on Muscle Apoptosis in Rats and the Role of Aerobic Training in Its Modulation","authors":"M. Jafari, P. Motamedi, N. Khaledi","doi":"10.32598/jsmj.20.4.2475","DOIUrl":"https://doi.org/10.32598/jsmj.20.4.2475","url":null,"abstract":"Background and Objectives Chronic Kidney Disease (CKD) is characterized by progressive and irreversible loss of renal function. One of the complications of this disease is muscle wasting and atrophy. The aim of this study was to determine the effect of exercise training on CKD-induced muscle apoptosis in rats. Subjects and Methods In the present developmental study, 30 rats were selected and divided into 3 groups: disease training, disease control and healthy controls. Induction of CKD was through primary and final 1.3 resection of one kidney and complete resection of the other kidney. The training program consisted of eight weeks of continuous running training with an intensity of 45-55% VO2max. After removal of EDL muscle, protein level and Bcl-2 and Bax gene expression were measured by immunohistochemistry and real-time PCR, respectively. Results Induction of CKD caused a significant increase in protein level and gene expression of Bax and Bax/Bcl-2 and a significant decrease in Bcl-2 compared to the healthy control group (P<0.001). Also significant decrease was funded in the expression of genes and proteins Bax and Bax/Bcl-2 (P<0.001) and a significant increase was funded in protein Bcl-2 (P<0.001), without significant changes in the gene expression of Bcl-2 (P=0.935) in disease training compared to the disease control. Conclusion The results of the present study support the anti-apoptotic effect of exercise on muscle tissue of CKD patients; therefore, it is recommended that clinical research be conducted in this regard for exercise recommendations for these patients.","PeriodicalId":17808,"journal":{"name":"Jundishapur Journal of Medical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84981912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leila Golpasandhagh, Mahsa Bahadori, Seyied Mohammad Ghaffari
Background and Objectives Periodontitis is an inflammatory disease that involves supporting tooth structure, can be affected by risk factors like smoking, and increase the prevalence and severity of periodontal damages. Antioxidant stress to target molecule and prevent from degeneration of normal cells. This study aimed to compare the salivary total antioxidant level in smokers and non-smokers with chronic periodontitis. Subjects and Methods A case-control study was performed in 60 chronic periodontitis patients (30 smokers and 30 non – smokers) in referral patients to Ahvaz Jundishapoor university of Medical Sciences, School of Dentistry. Saliva samples were collected from all subjects and the total salivary antioxidant level in these subjects measured with the spectrophotometry method in 600 nm wavelength. data analyzed with t-test statistical analysis. Results A significant difference between total salivary antioxidant level in smokers and non-Smokers patients with chronic periodontitis observed (P<0.001). Conclusion This study showed decreasing in total salivary antioxidant level in the smoker- patients with chronic periodontitis compared to non-smoker patients with chronic periodontitis.
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