Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01452-w
Alexandra Le Bras
{"title":"Efficacy of mucosal vaccines in nonhuman primates","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01452-w","DOIUrl":"10.1038/s41684-024-01452-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"264-264"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01440-0
Suzan Meijs, Andrew J. Hayward, Thomas Gomes Nørgaard Dos Santos Nielsen, Carsten Reidies Bjarkam, Winnie Jensen
This study describes cortical recordings in a large animal nerve injury model. We investigated differences in primary somatosensory cortex (S1) hyperexcitability when stimulating injured and uninjured nerves and how different cortical layers contribute to S1 hyperexcitability after spared ulnar nerve injury. We used a multielectrode array to record single-neuron activity in the S1 of ten female Danish landrace pigs. Electrical stimulation of the injured and uninjured nerve evoked brain activity up to 3 h after injury. The peak amplitude and latency of early and late peristimulus time histogram responses were extracted for statistical analysis. Histological investigations determined the layer of the cortex in which each electrode contact was placed. Nerve injury increased the early peak amplitude compared with that of the control group. This difference was significant immediately after nerve injury when the uninjured nerve was stimulated, while it was delayed for the injured nerve. The amplitude of the early peak was increased in layers III–VI after nerve injury compared with the control. In layer III, S1 excitability was also increased compared with preinjury for the early peak. Furthermore, the late peak was significantly larger in layer III than in the other layers in the intervention and control group before and after injury. Thus, the most prominent increase in excitability occurred in layer III, which is responsible for the gain modulation of cortical output through layer V. Therefore, layer III neurons seem to have an important role in altered brain excitability after nerve injury. Meijs et al. perform an electrophysiological investigation of cortical responses in a pig nerve injury model, showing the role of layer III–VI neurons in altered primary somatosensory cortex excitability after nerve injury.
{"title":"Spared ulnar nerve injury results in increased layer III–VI excitability in the pig somatosensory cortex","authors":"Suzan Meijs, Andrew J. Hayward, Thomas Gomes Nørgaard Dos Santos Nielsen, Carsten Reidies Bjarkam, Winnie Jensen","doi":"10.1038/s41684-024-01440-0","DOIUrl":"10.1038/s41684-024-01440-0","url":null,"abstract":"This study describes cortical recordings in a large animal nerve injury model. We investigated differences in primary somatosensory cortex (S1) hyperexcitability when stimulating injured and uninjured nerves and how different cortical layers contribute to S1 hyperexcitability after spared ulnar nerve injury. We used a multielectrode array to record single-neuron activity in the S1 of ten female Danish landrace pigs. Electrical stimulation of the injured and uninjured nerve evoked brain activity up to 3 h after injury. The peak amplitude and latency of early and late peristimulus time histogram responses were extracted for statistical analysis. Histological investigations determined the layer of the cortex in which each electrode contact was placed. Nerve injury increased the early peak amplitude compared with that of the control group. This difference was significant immediately after nerve injury when the uninjured nerve was stimulated, while it was delayed for the injured nerve. The amplitude of the early peak was increased in layers III–VI after nerve injury compared with the control. In layer III, S1 excitability was also increased compared with preinjury for the early peak. Furthermore, the late peak was significantly larger in layer III than in the other layers in the intervention and control group before and after injury. Thus, the most prominent increase in excitability occurred in layer III, which is responsible for the gain modulation of cortical output through layer V. Therefore, layer III neurons seem to have an important role in altered brain excitability after nerve injury. Meijs et al. perform an electrophysiological investigation of cortical responses in a pig nerve injury model, showing the role of layer III–VI neurons in altered primary somatosensory cortex excitability after nerve injury.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"287-293"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01440-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01451-x
Alexandra Le Bras
{"title":"A real-world setting for H1N1 transmission in ferrets","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01451-x","DOIUrl":"10.1038/s41684-024-01451-x","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"264-264"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01442-y
Lauren Danridge, Bill Greer, Jillian Hash, Denise Ancharski-Stutler, Joanna Fried, Ines Rodriguez, Louis DiVincenti
IACUC professionals depend on conferences and webinars as a primary source of regulatory information; what happens if they walk away with different interpretations of the regulations? We invited experts from The Children’s Hospital of Philadelphia (Jillian Hash and Denise Ancharski-Stutler) and University of Pennsylvania (Joanna Fried and Ines Rodriguez), along with USDA representative Louis DiVincenti, to respond to a scenario about the regulatory requirements for seminannual inspections.
{"title":"Two x two for USDA semiannual inspections","authors":"Lauren Danridge, Bill Greer, Jillian Hash, Denise Ancharski-Stutler, Joanna Fried, Ines Rodriguez, Louis DiVincenti","doi":"10.1038/s41684-024-01442-y","DOIUrl":"10.1038/s41684-024-01442-y","url":null,"abstract":"IACUC professionals depend on conferences and webinars as a primary source of regulatory information; what happens if they walk away with different interpretations of the regulations? We invited experts from The Children’s Hospital of Philadelphia (Jillian Hash and Denise Ancharski-Stutler) and University of Pennsylvania (Joanna Fried and Ines Rodriguez), along with USDA representative Louis DiVincenti, to respond to a scenario about the regulatory requirements for seminannual inspections.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"255-257"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01445-9
Jorge Ferreira
{"title":"Monkey model of ophthalmic degeneration","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01445-9","DOIUrl":"10.1038/s41684-024-01445-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"263-263"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01450-y
Alexandra Le Bras
{"title":"A nonhuman primate model of metabolic PASC","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01450-y","DOIUrl":"10.1038/s41684-024-01450-y","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"264-264"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142360085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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