Pub Date : 2026-02-03DOI: 10.1038/s41684-026-01685-x
Alexandra Le Bras
{"title":"A new chimeric in vitro model to study microglia","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01685-x","DOIUrl":"10.1038/s41684-026-01685-x","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 2","pages":"35-35"},"PeriodicalIF":3.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1038/s41684-026-01687-9
Alexandra Le Bras
{"title":"A new platform for detecting depressive-like behavior in mice","authors":"Alexandra Le Bras","doi":"10.1038/s41684-026-01687-9","DOIUrl":"10.1038/s41684-026-01687-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 2","pages":"35-35"},"PeriodicalIF":3.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-03DOI: 10.1038/s41684-026-01688-8
Jorge Ferreira
{"title":"Exercise improves cognitive function in mice","authors":"Jorge Ferreira","doi":"10.1038/s41684-026-01688-8","DOIUrl":"10.1038/s41684-026-01688-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 2","pages":"36-36"},"PeriodicalIF":3.9,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146103027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-16DOI: 10.1038/s41684-025-01668-4
Shohei Ochi, Hitoshi Inada, Noriko Osumi
Unbiased, scalable behavioral phenotyping that captures multi-animal interactions in home-cage settings is increasingly needed. Here we present ‘IntelliProfiler’, a research workflow consisting of data processing scripts that extract locomotor activity and pairwise proximity from a commercially available, previously validated, high-resolution radio frequency identification floor plate. IntelliProfiler is not a standalone system; it operates on data acquired with the Phenovance floor plate and is not yet validated with other hardware configurations. The workflow reconstructs individual trajectories and positions of multiple mice, enabling long-term assessment of locomotor activity and social spacing. In proof-of-concept analyses, male mice placed in a novel cage environment maintained greater inter-animal distances than female mice, an effect that strengthened as group size increased. Aging reduced locomotor activity in a group size-dependent manner and altered proximity patterns. In addition, offspring of aged fathers (a paternal-aging autism spectrum disorder model) exhibited hyperactivity and increased social distance relative to controls, consistent with autism spectrum disorder-related phenotypes and motivating further investigations. Together, these findings demonstrate that IntelliProfiler workflow provides a practical and versatile approach for screening group dynamics and quantifying complex social behaviors in neuroscience research. This study introduces IntelliProfiler, a software workflow for radio frequency identification-based analysis of locomotor activity and social spacing in mice, revealing sex, age and autism spectrum disorder model effects, enabling scalable, long-term behavioral phenotyping.
{"title":"IntelliProfiler: a research workflow for analyzing multiple animals with a high-resolution home-cage RFID system","authors":"Shohei Ochi, Hitoshi Inada, Noriko Osumi","doi":"10.1038/s41684-025-01668-4","DOIUrl":"10.1038/s41684-025-01668-4","url":null,"abstract":"Unbiased, scalable behavioral phenotyping that captures multi-animal interactions in home-cage settings is increasingly needed. Here we present ‘IntelliProfiler’, a research workflow consisting of data processing scripts that extract locomotor activity and pairwise proximity from a commercially available, previously validated, high-resolution radio frequency identification floor plate. IntelliProfiler is not a standalone system; it operates on data acquired with the Phenovance floor plate and is not yet validated with other hardware configurations. The workflow reconstructs individual trajectories and positions of multiple mice, enabling long-term assessment of locomotor activity and social spacing. In proof-of-concept analyses, male mice placed in a novel cage environment maintained greater inter-animal distances than female mice, an effect that strengthened as group size increased. Aging reduced locomotor activity in a group size-dependent manner and altered proximity patterns. In addition, offspring of aged fathers (a paternal-aging autism spectrum disorder model) exhibited hyperactivity and increased social distance relative to controls, consistent with autism spectrum disorder-related phenotypes and motivating further investigations. Together, these findings demonstrate that IntelliProfiler workflow provides a practical and versatile approach for screening group dynamics and quantifying complex social behaviors in neuroscience research. This study introduces IntelliProfiler, a software workflow for radio frequency identification-based analysis of locomotor activity and social spacing in mice, revealing sex, age and autism spectrum disorder model effects, enabling scalable, long-term behavioral phenotyping.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 2","pages":"48-63"},"PeriodicalIF":3.9,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-025-01668-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1038/s41684-025-01667-5
Michael P. Harris, Kay B. Barnes, Thomas R. Laws, Emily May, Michelle Nelson, Sarah V. Harding, Thomas C. Maishman
The development of humane endpoints is critical for refining scientific studies involving animals. Body weight and clinical signs of disease data collected in four recent studies assessing medical countermeasures for utility against the disease melioidosis in mice were further analyzed. Here we used this information to ascertain whether a suitable alternative humane endpoint could be identified. A total of 66 possible alternative humane endpoints were explored, which varied the threshold values of the ‘percentage body weight loss post-challenge’ and ‘the clinical signs over time’ following cessation of treatment. The findings indicated a suitable alternative endpoint of a percentage weight loss threshold of 25%, and/or using an average total clinical signs score ≥5 over a 48-h period. This endpoint resulted in a sizeable reduction in median ‘sign-days’ (total clinical score multiplied by the number of days remaining in study) per mouse of 21 days (ranging from 8 to 56 between studies), while maintaining 100% sensitivity and 93% specificity (ranging from 79% to 97% between studies). In addition, the risk of altering the scientific outcome of each study remained low when utilizing this new endpoint. In conclusion, current humane endpoints in this setting can be refined without negatively impacting the key study findings. The authors analyzed four melioidosis studies in mice to identify refined humane endpoints (25% weight loss and/or clinical score ≥5) that improve animal welfare while maintaining study integrity.
{"title":"Exploration of refined humane endpoints for melioidosis in BALB/c mice","authors":"Michael P. Harris, Kay B. Barnes, Thomas R. Laws, Emily May, Michelle Nelson, Sarah V. Harding, Thomas C. Maishman","doi":"10.1038/s41684-025-01667-5","DOIUrl":"10.1038/s41684-025-01667-5","url":null,"abstract":"The development of humane endpoints is critical for refining scientific studies involving animals. Body weight and clinical signs of disease data collected in four recent studies assessing medical countermeasures for utility against the disease melioidosis in mice were further analyzed. Here we used this information to ascertain whether a suitable alternative humane endpoint could be identified. A total of 66 possible alternative humane endpoints were explored, which varied the threshold values of the ‘percentage body weight loss post-challenge’ and ‘the clinical signs over time’ following cessation of treatment. The findings indicated a suitable alternative endpoint of a percentage weight loss threshold of 25%, and/or using an average total clinical signs score ≥5 over a 48-h period. This endpoint resulted in a sizeable reduction in median ‘sign-days’ (total clinical score multiplied by the number of days remaining in study) per mouse of 21 days (ranging from 8 to 56 between studies), while maintaining 100% sensitivity and 93% specificity (ranging from 79% to 97% between studies). In addition, the risk of altering the scientific outcome of each study remained low when utilizing this new endpoint. In conclusion, current humane endpoints in this setting can be refined without negatively impacting the key study findings. The authors analyzed four melioidosis studies in mice to identify refined humane endpoints (25% weight loss and/or clinical score ≥5) that improve animal welfare while maintaining study integrity.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 2","pages":"40-47"},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-025-01667-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1038/s41684-025-01673-7
Alexandra Le Bras
{"title":"Macaque models to study Lassa virus pathogenesis","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01673-7","DOIUrl":"10.1038/s41684-025-01673-7","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 1","pages":"8-8"},"PeriodicalIF":3.9,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1038/s41684-025-01672-8
Jorge Ferreira
{"title":"Effects of dietary folic acid in flies after hypoxia","authors":"Jorge Ferreira","doi":"10.1038/s41684-025-01672-8","DOIUrl":"10.1038/s41684-025-01672-8","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 1","pages":"7-7"},"PeriodicalIF":3.9,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145814595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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