Pub Date : 2025-12-11DOI: 10.1038/s41684-025-01666-6
Ana Isabel Santos, Nuno Henrique Franco
On March 18-19, 2025, the European Training Platform for Laboratory Animal Science (ETPLAS) held its first international conference, at the Leiden University Medical Centre in The Netherlands. The meeting gathered course organisers, accreditors, regulators, educators, researchers and animal welfare specialists from across Europe and beyond, who discussed ETPLAS contributions for advancing education and training in laboratory animal science, as well as its goals for the future.
{"title":"ETPLAS Conference: Shaping the future of LAS education and training","authors":"Ana Isabel Santos, Nuno Henrique Franco","doi":"10.1038/s41684-025-01666-6","DOIUrl":"10.1038/s41684-025-01666-6","url":null,"abstract":"On March 18-19, 2025, the European Training Platform for Laboratory Animal Science (ETPLAS) held its first international conference, at the Leiden University Medical Centre in The Netherlands. The meeting gathered course organisers, accreditors, regulators, educators, researchers and animal welfare specialists from across Europe and beyond, who discussed ETPLAS contributions for advancing education and training in laboratory animal science, as well as its goals for the future.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 1","pages":"1-3"},"PeriodicalIF":3.9,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145728439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1038/s41684-025-01651-z
Nuno Henrique Franco, Otto Kalliokoski, Vootele Voikar
The 16th FELASA Congress took place June 2025 in the cradle of science, Athens. Upon arrival, more than 2,000 professionals from 52 countries were welcomed by “Aristotle the Octopus”, a mascot alluding to Greek scientific heritage, Aristotle’s pioneering zoological observations and the values of intelligence, adaptability and ethics, which are central to laboratory animal science (LAS). The vibrant and friendly atmosphere was fertile ground for discussing advancements in LAS, regulation, education and ethics, but also for catching up with friends and colleagues, exchange ideas and start new collaborations. Having been involved in many aspects of the meeting – chairing sessions, delivering talks and workshops – we will share some insights and personal reflections on the meeting.
{"title":"The 2025 FELASA Congress in Athens: From Aristotle to AI","authors":"Nuno Henrique Franco, Otto Kalliokoski, Vootele Voikar","doi":"10.1038/s41684-025-01651-z","DOIUrl":"10.1038/s41684-025-01651-z","url":null,"abstract":"The 16th FELASA Congress took place June 2025 in the cradle of science, Athens. Upon arrival, more than 2,000 professionals from 52 countries were welcomed by “Aristotle the Octopus”, a mascot alluding to Greek scientific heritage, Aristotle’s pioneering zoological observations and the values of intelligence, adaptability and ethics, which are central to laboratory animal science (LAS). The vibrant and friendly atmosphere was fertile ground for discussing advancements in LAS, regulation, education and ethics, but also for catching up with friends and colleagues, exchange ideas and start new collaborations. Having been involved in many aspects of the meeting – chairing sessions, delivering talks and workshops – we will share some insights and personal reflections on the meeting.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"55 1","pages":"4-6"},"PeriodicalIF":3.9,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-025-01651-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145611563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41684-025-01655-9
Alexandra Le Bras
{"title":"A zebrafish model of chronic heart failure","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01655-9","DOIUrl":"10.1038/s41684-025-01655-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 12","pages":"338-338"},"PeriodicalIF":3.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41684-025-01662-w
Alexandra Le Bras
{"title":"Central metabolic activity is preserved in aged mice","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01662-w","DOIUrl":"10.1038/s41684-025-01662-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 12","pages":"341-341"},"PeriodicalIF":3.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-025-01662-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41684-025-01647-9
Nataliia Shapovalova, Thorsten Buch, Heinrich Bollwein, Johannes vom Berg, Eleni Malama
Cryopreservation of spermatozoa can be used as a cost-effective way of preserving the ever-increasing number of genetically modified mouse lines. Nevertheless, discontinuing the breeding of a line or strain is only warranted after the quality control of cryopreserved sperm; the ability of sperm to survive the freezing–thawing process and produce well-developed embryos needs to be confirmed. In animal research husbandries, the fertility of frozen-thawed sperm is routinely tested using in vitro fertilization. However, this procedure requires euthanizing a considerable number of females to acquire a sufficient number of oocytes, contradicting the ‘reduction’ principle of the 3Rs (replacement, reduction and refinement). Therefore, the research community has an interest in replacing in vitro fertilization tests with proxies that can collectively characterize the fertilizing potential of mouse sperm. Methods such as computer-assisted sperm analysis and flow cytometry enable a precise and multiparametric approach to evaluate sperm quality, encompassing ‘traditional’ traits and the functional status of subcellular structures of sperm. Moreover, single-cell data can be processed with machine learning algorithms, offering a deeper insight into sperm physiology and functional heterogeneity. Despite the advancements made, many of these assays are still far from being used in mouse sperm quality control owing to their limited time- and cost-efficiency, the insufficiency of fertility validation studies, and the complex data analysis needed to identify fertility markers. The genetic and phenotypic diversity of different mouse strains and lines makes the establishment of a robust methodology for fertility prognostics even more challenging. Thus, this Review summarizes the available methods for assessing sperm functional characteristics in laboratory mice and discusses their contribution to fertility prognosis. Cryopreservation of spermatozoa preserves genetically modified mouse lines, but quality control is critical. Given that in vitro fertilization testing presents limitations, this Review explores other available methods to evaluate sperm quality.
{"title":"Beyond swimming: emerging parameters for predicting the fertility of mouse spermatozoa","authors":"Nataliia Shapovalova, Thorsten Buch, Heinrich Bollwein, Johannes vom Berg, Eleni Malama","doi":"10.1038/s41684-025-01647-9","DOIUrl":"10.1038/s41684-025-01647-9","url":null,"abstract":"Cryopreservation of spermatozoa can be used as a cost-effective way of preserving the ever-increasing number of genetically modified mouse lines. Nevertheless, discontinuing the breeding of a line or strain is only warranted after the quality control of cryopreserved sperm; the ability of sperm to survive the freezing–thawing process and produce well-developed embryos needs to be confirmed. In animal research husbandries, the fertility of frozen-thawed sperm is routinely tested using in vitro fertilization. However, this procedure requires euthanizing a considerable number of females to acquire a sufficient number of oocytes, contradicting the ‘reduction’ principle of the 3Rs (replacement, reduction and refinement). Therefore, the research community has an interest in replacing in vitro fertilization tests with proxies that can collectively characterize the fertilizing potential of mouse sperm. Methods such as computer-assisted sperm analysis and flow cytometry enable a precise and multiparametric approach to evaluate sperm quality, encompassing ‘traditional’ traits and the functional status of subcellular structures of sperm. Moreover, single-cell data can be processed with machine learning algorithms, offering a deeper insight into sperm physiology and functional heterogeneity. Despite the advancements made, many of these assays are still far from being used in mouse sperm quality control owing to their limited time- and cost-efficiency, the insufficiency of fertility validation studies, and the complex data analysis needed to identify fertility markers. The genetic and phenotypic diversity of different mouse strains and lines makes the establishment of a robust methodology for fertility prognostics even more challenging. Thus, this Review summarizes the available methods for assessing sperm functional characteristics in laboratory mice and discusses their contribution to fertility prognosis. Cryopreservation of spermatozoa preserves genetically modified mouse lines, but quality control is critical. Given that in vitro fertilization testing presents limitations, this Review explores other available methods to evaluate sperm quality.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 12","pages":"343-354"},"PeriodicalIF":3.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41684-025-01647-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-26DOI: 10.1038/s41684-025-01654-w
Alexandra Le Bras
{"title":"Role of hypercapnia in COPD pathology","authors":"Alexandra Le Bras","doi":"10.1038/s41684-025-01654-w","DOIUrl":"10.1038/s41684-025-01654-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"54 12","pages":"338-338"},"PeriodicalIF":3.9,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145601239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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