Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01448-6
Jorge Ferreira
{"title":"Health impact of different fats in rats","authors":"Jorge Ferreira","doi":"10.1038/s41684-024-01448-6","DOIUrl":"10.1038/s41684-024-01448-6","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"265-265"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01448-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-30DOI: 10.1038/s41684-024-01441-z
Monique Brouillette
Researchers have been exploring the transplantation of pig organs as a solution to a worldwide shortage of donated organs.
研究人员一直在探索用猪器官移植来解决全世界捐赠器官短缺的问题。
{"title":"Can designer pigs solve the organ shortage?","authors":"Monique Brouillette","doi":"10.1038/s41684-024-01441-z","DOIUrl":"10.1038/s41684-024-01441-z","url":null,"abstract":"Researchers have been exploring the transplantation of pig organs as a solution to a worldwide shortage of donated organs.","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 10","pages":"259-262"},"PeriodicalIF":5.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01441-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142349362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-17DOI: 10.1038/s41684-024-01439-7
Kaylynn Monarch, Junchul Yoon, Kyungjun Uh, Emily Reese, Diana Canaveral Restrepo, Darling Melany de Carvalho Madrid, Laurie Touchard, Lee D. Spate, Melissa S. Samuel, John P. Driver, Ji-Hey Lim, Sarah Schlink, Kristin M. Whitworth, Kevin D. Wells, Randall S. Prather, Paula R. Chen, Kiho Lee
Genetic modification of genes such as recombination activating gene 2 (RAG2) or interleukin-2 receptor-γ (IL2RG) results in pigs exhibiting severe combined immunodeficiency (SCID). Pigs presenting a SCID phenotype are important animal models that can be used to establish xenografts and to study immune system development and various immune-related pathologies. However, due to their immunocompromised nature, SCID pigs have shortened lifespans and are notoriously difficult to maintain. The failure-to-thrive phenotype makes the establishment of a breeding population of RAG2/IL2RG double-knockout pigs virtually impossible. Here, to overcome this limitation, we investigated whether reconstituting the immune system of SCID piglets with a fetal bone allograft would extend their lifespan. Following intramuscular transplantation, allografts gave rise to lymphocytes expressing T cell (CD3, CD4 and CD8), B cell (CD79α) and natural killer cell (CD335) lineage markers, which were detected in circulation as well in the spleen, liver, bone marrow and thymic tissues. The presence of lymphocytes indicates broad engraftment of donor cells in the recipient SCID pigs. Unlike unreconstituted SCID pigs, the engrafted animals thrived and reached puberty under standard housing conditions. This study demonstrates a novel method to extend the survival of SCID pigs, which may improve the availability and use of SCID pigs as a biomedical animal model. Severe combined immunodeficiency (SCID) pigs do not live long enough to reproduce naturally. Monarch et al. show that reconstituting the immune system of SCID piglets with fetal bone allografts extends their lifespan, allowing them to reach puberty.
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Pub Date : 2024-08-30DOI: 10.1038/s41684-024-01437-9
Alexandra Le Bras
{"title":"Role of oligodendrocytes in Aβ plaque burden","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01437-9","DOIUrl":"10.1038/s41684-024-01437-9","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 9","pages":"222-222"},"PeriodicalIF":5.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41684-024-01437-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-30DOI: 10.1038/s41684-024-01428-w
Alexandra Le Bras
{"title":"A new zebrafish model of SHH medulloblastoma","authors":"Alexandra Le Bras","doi":"10.1038/s41684-024-01428-w","DOIUrl":"10.1038/s41684-024-01428-w","url":null,"abstract":"","PeriodicalId":17936,"journal":{"name":"Lab Animal","volume":"53 9","pages":"218-218"},"PeriodicalIF":5.9,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142100824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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