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Antioxidant potential, anti-inflammatory activity, antidiabetic and cardioprotective effect of Microsechium helleri (Peyr.) Cong. 微紫堇的抗氧化潜力、抗炎活性、抗糖尿病和心脏保护作用丛。
Pub Date : 2021-05-15 DOI: 10.37360/BLACPMA.21.20.5.39
E. Méndez-Bolaina, M. Vázquez-Hernández, C. V. Moreno-Quiros, Octavio Maldonado-Saavedra, David Luna-Orea, E. V. Herrera-Huerta, R. García-Rodríguez
Microsechium helleri (Cucurbitaceae) has been used in ethnopharmacological as a lotion to prevent hair loss, diuretic and cathartic, in the region of central Veracruz, Mexico is used as antidiabetic. The antioxidant properties of the hexanic (EHex), chloroformic (ECHCl3) and ethanolic (EEtOH) extracts, were evaluated by 2,2diphenyl-1-pychrylhydrazyl (DPPH) test, the Ferric Reducing/Antioxidant Power (FRAP) and the total phenolic content test. The anti-inflammatory effect was evaluated in the acute ear edema induced with phorbol 12-myristate 13-acetate (TPA) in mouse and the hypoglycemic and cardioprotective effects of the EEtOH were determined in rats. The EEtOH was the most active in the antioxidant potential DPPH test and the ECHCl3 was the best in the FRAP assay and the total polyphenols content. In the anti-inflammatory assay, the ECHCl3 showed the most activity. The EEtOH had the decreased the glucose levels and reduced myocardial damage. The results support the use of this plant in folk medicine in Mexico as antioxidant, anti-inflammatory, hypoglycemic and cardioprotective.
葫芦科(Microsechium helleri)在民族药理学上被用作防止脱发的洗剂,利尿剂和泻药,在墨西哥韦拉克鲁斯中部地区被用作抗糖尿病药。采用2,2二苯基-1-芘酰肼(DPPH)试验、铁还原/抗氧化能力(FRAP)试验和总酚含量试验对己烷(EHex)、氯甲酸(ECHCl3)和乙醇(EEtOH)提取物的抗氧化性能进行了评价。观察12-肉豆蔻酸13-乙酸佛波酯(TPA)致小鼠急性耳部水肿的抗炎作用和大鼠降血糖、保护心脏的作用。在抗氧化潜能DPPH试验中,etoh活性最高,在FRAP试验和总多酚含量试验中,ECHCl3活性最高。抗炎实验中,ECHCl3活性最强。etoh降低了血糖水平,减少了心肌损伤。结果支持墨西哥民间医药中使用这种植物作为抗氧化、抗炎、降血糖和保护心脏。
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引用次数: 0
Estudio etnobotánico de Cataia (Pimenta pseudocaryophyllus (Gomes) Landrum) en el Parque Nacional de Superagui, Guaraqueçaba/PR/Brasil Superagui国家公园Cataia (Pimenta pseudocaryophyllus (Gomes) Landrum)的民族植物学研究,guaracaba /PR/巴西
Pub Date : 2021-01-05 DOI: 10.37360/BLACPMA.21.20.1.8
Amanda Sr D’Angelis, Raquel Rb Negrelle
Cataia is a Myrtaceae of great aromatic and medicinal potential. On the coast of Parana there is a record of increasing commercial use of its leaves in the aromatization of brandy. In order to better understand the exploitation of cataia from a historical perspective, as well as elucidate the ecological knowledge of the inhabitants about the management, the results of an ethnobotanical investigation carried out in Barra do Ararapira are presented. Data collect has involved individual and group interviews and monitoring of all extractor’s activities. It was elucidated a sustainability potential, denoted at first instance by institutional support to confer legality to the activity and for their implementation, and the community organizational capacity. As regards to the ecological question, the low demand now existent was considerate a positive aspect, but is highlight the importance of a continuous monitoring of possible damage. Regarding the value chain was evidenced the absence of intermediaries and the regular sale to traders of the region, featuring a favorable marketing component.
龙葵是一种具有芳香和药用价值的桃金娘科植物。在巴拉那海岸,有越来越多的商业使用它的叶子来芳香化白兰地的记录。为了从历史的角度更好地了解卡塔亚的开发,以及阐明居民对管理的生态知识,在巴拉多阿拉皮拉进行的民族植物学调查的结果。数据收集涉及个人和小组访谈以及对所有采掘者活动的监测。它阐明了一种可持续性的潜力,首先表现为为活动及其执行提供合法性的机构支助,以及社区组织能力。关于生态问题,目前存在的低需求是考虑到一个积极的方面,但它强调了持续监测可能的破坏的重要性。在价值链方面,没有中介机构,定期向该地区的贸易商销售,具有有利的营销成分。
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引用次数: 0
Productos naturales radioprotectores como complementos alternativos en la radioterapia oncológica 作为补充替代天然产品radioprotectores放疗肿瘤
Pub Date : 2021-01-04 DOI: 10.37360/BLACPMA.21.20.2.9
Subhajit Dutta, Raju R Wadekar, Tilottama Roy
Humans when exposed to harmful ionising radiations suffer from various pathophysiological disorders including cancer. Radiotherapy is a treatment where these cancerous cells within a tumor are targeted and killed by means of high energy waves. This therapy is very expensive and involves highly sophisticated instruments. In addition to this, most synthetic radioprotectors including Amifostine have been found to possess toxicity. This led researchers to develop a novel, economically viable, and efficient therapeutic alternative to radiation therapy. The last two decades have observed a major shift towards investigating natural products as radioprotectors, as these are immensely effective in terms of their potential bioequivalence relative to many of the established synthetic compounds available. Taking into account the limitations of radiation therapy, an approach ‘Integrative Oncology’ that involves a combination of both traditional and conventional medical treatment are used nowadays to treat patients suffering from cancer and associated mental and psychological disorders.
当暴露于有害的电离辐射时,人类会患上各种病理生理障碍,包括癌症。放射治疗是一种用高能量波瞄准并杀死肿瘤内癌细胞的治疗方法。这种疗法非常昂贵,而且需要使用非常复杂的仪器。除此之外,包括氨磷汀在内的大多数合成辐射防护剂已被发现具有毒性。这促使研究人员开发出一种新的、经济上可行的、有效的替代放射治疗的治疗方法。在过去的二十年中,人们观察到研究天然产物作为辐射防护剂的重大转变,因为它们相对于许多现有的合成化合物具有潜在的生物等效性,因此非常有效。考虑到放射治疗的局限性,目前采用一种"综合肿瘤学"方法,将传统和常规医学治疗相结合,用于治疗患有癌症和相关精神和心理疾病的患者。
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引用次数: 4
Efecto antinociceptivo y antiinflamatorio del aceite esencial de Lippia pedunculosa Hayek y su complejo de inclusión de β-ciclodextrina 长柄利皮精油及其β-环糊精包合物的抗伤害和抗炎作用
Pub Date : 2021-01-04 DOI: 10.37360/BLACPMA.21.20.2.13
Renan Marinho Braga, Humberto Hugo Nunes de Andrade, Humberto de Carvalho Aragão Neto, Ryldene Marques Duarte da Cruz, Davidson Barbosa Assis, Luiz Henrique Agra Cavalcante-Silva, Sandra Rodriguez-Mascarenhas, Liana Clébia de Morais Pordeus, L. J. Quintans-Júnior, Reinaldo Nóbrega de Almeida
Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great suffering and disability and the drugs most often used have undesirable side effects. We also evaluated whether the inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able to improve the antinociceptive activity of the EOLp alone. Data were evaluated by analysis of variance (ANOVA), followed by Tukey’s test. Differences were considered significant if p<0.05. EOLp presented better antinociceptive effect when compared to the EOLp/β-CD inclusion complex. Thus, cyclodextrins appear not to be efficient for essential oils with peroxide substances. However, in peritonitis, EOLp reduced total leucocyte migration and IL-1β levels in the peritoneal fluid, which confirmed its anti-inflammatory effect. The observed effects suggest that EOLp is the best promising option for the treatment of inflammation and pain-related disorders.
peppia peduncullosa Hayek (EOLp)具有三萜和阿米巴霉素的作用。然而,一旦人群中普遍存在的疼痛造成了巨大的痛苦和残疾,并且最常用的药物有不良的副作用,精油就需要在镇痛和炎症的实验模型中进一步研究。我们还评估了包合物EOLp/β-环糊精(β-CD)是否能够提高EOLp单独的抗伤活性。采用方差分析(ANOVA)对数据进行评估,然后进行Tukey检验。p<0.05认为差异有统计学意义。与EOLp/β-CD包合物相比,EOLp具有更好的抗伤害感受作用。因此,环糊精似乎对含有过氧化物物质的精油无效。然而,在腹膜炎中,EOLp降低了腹膜液中白细胞总迁移和IL-1β水平,证实了其抗炎作用。观察到的效果表明,EOLp是治疗炎症和疼痛相关疾病的最佳选择。
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引用次数: 2
Tratamiento etnofarmacológico de la tos en Piran, Malakand, Pakistán 巴基斯坦马拉坎邦皮兰咳嗽的民族药理学治疗
Pub Date : 2021-01-04 DOI: 10.37360/BLACPMA.21.20.2.16
Majid Khan, Muhammad Ali, Rahmar Ullah, Latif Ahmad, Muhammad Riaz
The current study was designed to investigate the traditional recipes used to treat cough in Tehsil Piran, Malakand, Pakistan. These recipes were explored and quantitively analyzed for the first time. A total of 30 species of the plants, 6 animal products and one salt were reported to be used by the community to treat cough. Punica granatum L. and Olea ferruginea Royle dominated with Use value (UV) of 0.84 and Origanum vulgare L. with least use value of 0.1. The frequency citation (FC) of the Papaver somniferum L. is higher (98) while the lowest one is Verbascum thapsus L. (0.13). The large number of traditional recipes used for cough in this area shows that primary health care is still amalgamated in this culture. In future studies, these recipes may be further exploited as a base for modern medicine.
目前的研究旨在调查巴基斯坦马拉坎德Tehsil Piran地区用于治疗咳嗽的传统配方。本文首次对这些配方进行了探索和定量分析。据报道,该社区用于治疗咳嗽的植物共有30种,动物产品6种,盐1种。石榴和油橄榄的利用值(UV)最高,为0.84,最小的利用值为0.1。木瓜(Papaver somniferum L.)的被引频次最高(98),最低的是Verbascum thapsus L.(0.13)。这一地区大量用于治疗咳嗽的传统配方表明,初级卫生保健在这一文化中仍然存在。在未来的研究中,这些配方可能会进一步开发为现代医学的基础。
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引用次数: 0
Actividad antioxidante y antibacteriana del aceite esencial de hoja de Myrcianthes pungens 桃金娘叶精油的抗氧化和抗菌活性
Pub Date : 2021-01-04 DOI: 10.37360/BLACPMA.21.20.2.12
Renan Almeida de Jesus, Hérika Line Marko de Oliveira, Wanessa de Campos Bortolucci, Caio Franco de Araújo Almeida Campo, Maria Graciela Iecher Faria, José Eduardo Gonçalves, Nelson Barros Colauto, Zilda Cristiani Gazim, Giani Andrea Linde
Myrcianthes pungens (Myrtaceae) is a native tree to Brazil known as guabiju. In our study, we described the chemical composition of the essential oil from M. pungens dried leaves, the antioxidant activity by different methods and antibacterial activity against Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa. The chemical identification was done by gas chromatograph coupled to mass spectrometer and antibacterial activity was evaluated by broth microdilution method. The leaf essential oil presented hydrocarbon sesquiterpenes (42.6%) as its main chemical class whose major compounds were β-caryophyllene (11.7%) and 1,8-cineole (10.1%). The best antioxidant protection was from 57.5 to 63.3% of β-carotene. The highest antibacterial activity was against S. aureus (MIC of 78.12 μg/mL). This value was 2.56-fold lower than the positive streptomycin control. M. pungens is a promising source of natural molecules with potential study for the development of pharmacological, cosmetic and food products.
桃金娘(桃金娘科)是巴西的一种原生树木,被称为瓜比菊。本文研究了蓬根干叶挥发油的化学成分、不同处理方法的抗氧化活性以及对金黄色葡萄球菌、蜡样芽孢杆菌和铜绿假单胞菌的抑菌活性。采用气相色谱联用质谱仪进行化学鉴定,用微量肉汤稀释法进行抑菌活性评价。其主要化学成分为烃类倍半萜(42.6%),主要化合物为β-石竹烯(11.7%)和1,8-桉树脑(10.1%)。抗氧化保护效果最好的是β-胡萝卜素含量为57.5 ~ 63.3%。对金黄色葡萄球菌的抑菌活性最高(MIC为78.12 μg/mL)。这一数值比链霉素阳性对照低2.56倍。pungens是一种很有前途的天然分子来源,在药理、化妆品和食品等方面具有潜在的研究潜力。
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引用次数: 3
Antiproliferative activity from Aldama arenaria(Baker) E. E. Schill. & Panero alama arenaria(Baker) E. E. Schill的抗增殖活性。& Panero
Pub Date : 2021-01-01 DOI: 10.37360/blacpma.21.20.1.4
A. D. S. S. de Oliveira, P. M. Imamura, A. Ruiz, B. Appezzato‐da‐Glória, T. D. de Oliveira, V. L. Garcia
Chloroform extract (CE) and fractions obtained from Aldama arenariaroots were evaluated for their in vitroantiproliferative activity against 10 human tumor cell lines [leukemia (K-562), breast (MCF-7), ovary expressing a multidrug-resistant phenotype (NCI/ADR-RES), melanoma (UACC-62), lung (NCI-H460), prostate (PC-3), colon (HT29), ovary (OVCAR-3), glioma (U251), and kidney (786-0)]. CE presented weak to moderate antiproliferative activity (mean log GI501.07), whereas fractions 3 and 4, enriched with pimarane-type diterpenes [ent-pimara-8(14),15-dien-19-oic acid and ent-8(14),15-pimaradien-3β-ol], presented moderate to potent activity for most cell lines, with mean log GI50of 0.62 and 0.59, respectively. The results showed promising in vitroantiproliferative action of the samples obtained from A. arenaria, with the best results for NCI/ADR-RES, HT29, and OVCAR-3, and TGI values ranging from 5.95 to 28.71 μg.mL-1, demonstrating that compounds of this class may be potential prototypes for the discovery of new therapeutic agents.
我们评估了从沙参根中提取的氯仿提取物(CE)和组分对10种人类肿瘤细胞系[白血病(K-562)、乳腺癌(MCF-7)、表达多重耐药表型的卵巢(NCI/ADR-RES)、黑色素瘤(UACC-62)、肺(NCI- h460)、前列腺(PC-3)、结肠(HT29)、卵巢(OVCAR-3)、胶质瘤(U251)和肾脏(786-0)]的体外抗增殖活性。CE具有弱至中等的抗增殖活性(平均对数GI50为1.07),而富含海马烷型二萜[-海马烷-8(14),15-二烯-19-酸和-8(14),15-海马烷-3β-醇]的组分3和组分4对大多数细胞系具有中至强的抗增殖活性,平均对数GI50分别为0.62和0.59。结果表明,沙棘样品具有良好的体外抗增殖作用,其中NCI/ADR-RES、HT29和OVCAR-3的抗增殖效果最好,TGI值在5.95 ~ 28.71 μg之间。mL-1,表明该类化合物可能是发现新治疗剂的潜在原型。
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引用次数: 2
Insecticidal activity ofGallesia integrifolia (Phytolaccaceae) essential oil 植物科合欢精油的杀虫活性研究
Pub Date : 2021-01-01 DOI: 10.37360/blacpma.21.20.1.3
Keila Fernanda Raimundo, W. Bortolucci, I. L. Rahal, Hérika Line Marko de Oliveira, R. P. Junior, Caio Franco de Araújo Almeida Campo, J. Gonçalves, G. Linde, N. Colauto, Z. C. Gazim
This study evaluated the insecticidal activity of Gallesia integrifoliaessential oil from fruits, leaves, and flowers against Aedes aegyptilarvae and pupae. The essential oil was obtained by hydrodistillation and characterized by gas chromatography-mass spectrometry. Sulfur compounds represented 95 to 99% of the essential oil from fruits, leaves, and flowers. Essential oil major compounds were 2,8-dithianonane (52.6%) in fruits, 3,5-dithiahexanol-5,5-dioxide (38.9%) in leaves, and methionine ethyl ester (45.3%) in flowers. The essential oils showed high activity against larvae, and low for pupae withLC99.9of 5.87 and 1476.67μg/mL from fruits; 0.0096 and 348.33 μg/mL from leaves and 0.021and 342.84 μg/mL from flowers, respectively. The main compound with insecticide activity is probably n-ethyl-1,3-dithioisoindole, from isoindole organothiophosphate class, found in greater amount in flower and leaf essential oil. The great insecticide activity of G. integrifoliaessential oil suggests that this product is a natural insecticide.
本研究评价了果、叶、花三种不同成分的全叶甘露精油对埃及伊蚊幼虫和蛹的杀虫活性。采用水蒸气蒸馏法得到精油,并用气相色谱-质谱法对其进行了表征。含硫化合物占水果、树叶和花朵精油的95%到99%。精油主要成分为果实中的2,8-二硫烷(52.6%)、叶片中的3,5-二硫己醇-5,5-二氧化(38.9%)和花中的蛋氨酸乙酯(45.3%)。精油对幼虫的活性较高,对蛹的活性较低,lc99.9分别为5.87和1476.67μg/mL;叶片中含量分别为0.0096和348.33 μg/mL,花中含量分别为0.021和342.84 μg/mL。具有杀虫活性的主要化合物可能是n-乙基-1,3-二硫代异吲哚,属于异吲哚有机硫代磷酸酯类,在花叶精油中含量较多。藿香精油具有很强的杀虫活性,表明该产品是一种天然的杀虫剂。
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引用次数: 3
Multivariate statistical analysis of the essential oils of five Beilschmiediaspecies from Peninsular Malaysia 马来西亚半岛五种贝氏属植物精油的多元统计分析
Pub Date : 2021-01-01 DOI: 10.37360/blacpma.21.20.1.5
Wan Mohd Nuzul Hakimi Wan Salleh, S. M. Shaharudin
Identification of the chemical compositionof essential oils is very important for ensuring the quality of finished herbal products. The objective of the study was to analyze the chemical components present in the essential oils of five Beilschmiediaspecies (i.e. B. kunstleri, B. maingayi, B. penangiana, B. madang, and B. glabra) by multivariate data analysis using principal component analysis (PCA) and hierarchical clustering analysis (HCA) methods. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 108 chemical components were successfully identified from the essential oils of five Beilschmiediaspecies. The essential oils were characterized by high proportions of β-caryophyllene (B.kunstleri), δ-cadinene (B. penangianaand B. madang), and β-eudesmol (B. maingayiand B. glabra). Principal component analysis (PCA) and hierarchical cluster analysis (HCA) revealed that chemical similarity was highest for all samples, except for B. madang. The multivariate data analysis may be used for the identification and characterization of essential oils from different Beilschmiediaspecies that are to be used as raw materials of traditional herbal products.
精油的化学成分鉴定对保证中药成品的质量非常重要。本研究采用主成分分析(PCA)和层次聚类分析(HCA)方法,对5种白麻属植物(B. kunstleri、B. maingayi、B. penangiana、B. madang和B. glabra)挥发油的化学成分进行分析。采用水蒸气蒸馏法提取精油,并采用气相色谱法(GC)和气相色谱-质谱法(GC- ms)对其进行了表征。从5种贝氏属植物精油中成功鉴定出108种化学成分。其中β-石竹烯(B.kunstleri)、δ-cadinene (B. penangianab . madang)和β- udesmol (B. maingayib . glabra)含量较高。主成分分析(PCA)和层次聚类分析(HCA)表明,除马丹外,所有样品的化学相似性最高。多变量数据分析可用于不同种属植物精油的鉴别和表征,可作为传统草药产品的原料。
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引用次数: 1
Ethnomedicinal use value of the flora of the Hill “La Botica” used by the Andean Community of Cachicadán - Perú 安第斯群落Cachicadán - Perú使用的“La Botica”山植物群的民族医药利用价值
Pub Date : 2020-11-30 DOI: 10.37360/blacpma.20.19.6.43
Anavely L Alipio-Rodriguez, José Mostacero-León, Eloy Lopéz-Medina, Anthony J. de la Cruz-Castillo, A. Gil-Rivero
The present investigation was aimed at determining the value of ethnomedicinal use that is given to the flora of the Hill "La Botica", by the Andean Community of Cachicadán, Santiago de Chuco, Perú. 96 semi-structured interviews were applied, following the “snowball” technique. Collections were made by botanical explorations.For each of the species, family data, scientific and common name, part used, disease or disease treated, location in UTM and use value index (IVU) were detailed. 48 species of flora are used ethnobotanically by the Andean Community of Cachicadán, distributed in 46 genera and 26 families, of which they stand out for their number of species: Asteraceae (10), Rosaceae (5) and Lamiaceae (3). Of these, 72% (35 species) are very important for the cure or treatment of their diseases, according to their use value (IVU). In addition the inhabitants of the Andean Community of Cachicadán, report suffering from 38 diseases or ailments; grouped into 10 categories, where they prevail, those of the systems: respiratory (FCI = 0.88), digestive and gastrointestinal (FCI = 0.85), reproductive (FCI = 0.84), urinary (FCI = 0.84), nervous (FCI = 0.83), Musculoskeletal (FCI = 0.82), cardiovascular (FCI = 0.82) and rituals (FCI = 0.81).
本调查的目的是确定Cachicadán, Santiago de chuo, Perú的安第斯社区赋予“La Botica”山植物群的民族医学价值。采用“滚雪球”技术,采用了96个半结构化访谈。收藏品是通过植物探险得来的。详细描述了每种植物的科数、学名和常用名称、使用部位、治疗疾病或疾病、在UTM中的位置和使用价值指数(IVU)。Cachicadán的安第斯群落在民族植物学上利用了48种植物,分布于26科46属,其中以种数最为突出:Asteraceae (10), Rosaceae(5)和Lamiaceae(3)。其中72%(35种)的植物根据其使用价值(IVU)对其疾病的治疗非常重要。此外,Cachicadán安第斯共同体的居民报告患有38种疾病或病症;将这些系统分为10类:呼吸系统(FCI = 0.88)、消化和胃肠系统(FCI = 0.85)、生殖系统(FCI = 0.84)、泌尿系统(FCI = 0.84)、神经系统(FCI = 0.83)、肌肉骨骼系统(FCI = 0.82)、心血管系统(FCI = 0.82)和仪式系统(FCI = 0.81)。
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引用次数: 0
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Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants
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