Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.41
R. Ahmad, Hawra Adnan Alsadah, M. Riaz, L. H. AlLehaibi, Reem Ahmed Alraya, Ahmed Aljamea, S. Zahoor
This review present Gingko biloba (GB) interactions, based on clinical and pre-clinical presentations. Literature was retrieved using databases; ScienceDirect, PubMed, Google scholar, Web of Science, Scopus etc. 14/45 interactions were found with clinical presentations. More interactions (80%) were reported with drugs followed by herbs (11.1%), and nutraceuticals (6.7%) with major mechanisms of interaction observed as; inhibition of Cytochrome metabolizing enzymes (44.4%) and platelet-activating factor (PAF) i.e. 15.6%. Major clinical features were; increased bleeding (eye, parietal), hematomas (subdural), and seizures as well as increased blood pressure, priapism, loss of infection/antiviral failure, and coma. Drugs with major interactions belonged to anti-platelet/anti-coagulant and NSAIDs. Synergistic effects were observed for GB vs herbs (except cannabis which showed rhabdomyolysis), foods, and nutraceuticals (except pyridoxine where neurotoxicity was seen). GB use should be monitored and the patient may seek proper advice from a healthcare professional.
本文综述了银杏叶(GB)的相互作用，基于临床和临床前的表现。使用数据库检索文献;ScienceDirect、PubMed、Google scholar、Web of Science、Scopus等与临床报告的交互为14/45。据报道，与药物的相互作用最多(80%)，其次是草药(11.1%)和营养保健品(6.7%)，主要相互作用机制为;抑制细胞色素代谢酶(44.4%)和血小板活化因子(PAF)(15.6%)。主要临床特征有;出血增加(眼、顶骨)、血肿(硬膜下)、癫痫发作以及血压升高、阴茎勃起、感染丧失/抗病毒功能失效和昏迷。主要相互作用药物为抗血小板/抗凝血药和非甾体抗炎药。协同效应被观察到GB与草药(除了大麻，它表现出横纹肌溶解)，食物和营养药品(除了吡哆醇，它的神经毒性被观察到)。应监测GB的使用情况，患者可向医疗保健专业人员寻求适当的建议。
{"title":"The dietary supplement of Ginkgo biloba: a comprehensive review of its potential interactions based on pre-clinical and clinical evidences","authors":"R. Ahmad, Hawra Adnan Alsadah, M. Riaz, L. H. AlLehaibi, Reem Ahmed Alraya, Ahmed Aljamea, S. Zahoor","doi":"10.37360/BLACPMA.21.20.6.41","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.41","url":null,"abstract":"This review present Gingko biloba (GB) interactions, based on clinical and pre-clinical presentations. Literature was retrieved using databases; ScienceDirect, PubMed, Google scholar, Web of Science, Scopus etc. 14/45 interactions were found with clinical presentations. More interactions (80%) were reported with drugs followed by herbs (11.1%), and nutraceuticals (6.7%) with major mechanisms of interaction observed as; inhibition of Cytochrome metabolizing enzymes (44.4%) and platelet-activating factor (PAF) i.e. 15.6%. Major clinical features were; increased bleeding (eye, parietal), hematomas (subdural), and seizures as well as increased blood pressure, priapism, loss of infection/antiviral failure, and coma. Drugs with major interactions belonged to anti-platelet/anti-coagulant and NSAIDs. Synergistic effects were observed for GB vs herbs (except cannabis which showed rhabdomyolysis), foods, and nutraceuticals (except pyridoxine where neurotoxicity was seen). GB use should be monitored and the patient may seek proper advice from a healthcare professional.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75403487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.48
T. Fernandes, Túlio Baroso Queiroz, S. Rocha, Francine Souza Alves da Fonseca, Alcinei Mistico Azevedo, Gustavo Leal Teixeira, Ernane Ronie Martins
Varronia curassavica has anti-inflammatory properties because of the terpenes, α-humulene and β-caryophyllene, present in the essential oil. The objective of this study was to evaluate the influence of seasonality on the essential oil of V. curassavica accessions. Leaves from six accessions were collected from the Germplasm Bank of the Federal University of Minas Gerais over 12 months. Correlations between the essential oil content and meteorological factors were determined. Gas chromatography analysis coupled with mass spectrometry was conducted to determine the chemical composition of the essential oil. The content and chemical composition of the oil varied throughout the year. Relative humidity was correlated with accessions ICA-VC2 (-0.64) and ICA-VC4 (0.68). β-bourbonene, β-elemene, spathulenol, germacrene, caryophyllene oxide, α-humulene, and β-caryophyllene occurred in all accessions. Accession ICA-VC3 exhibited lower variation (22.17%), higher average (0.97%) essential oil, and maintained an average abundance of α-humulene greater than 2.6%, which is the amount necessary for phytotherapeutics.
{"title":"Variación estacional en el aceite esencial de accesiones de Varronia curassavica Jacq.","authors":"T. Fernandes, Túlio Baroso Queiroz, S. Rocha, Francine Souza Alves da Fonseca, Alcinei Mistico Azevedo, Gustavo Leal Teixeira, Ernane Ronie Martins","doi":"10.37360/BLACPMA.21.20.6.48","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.48","url":null,"abstract":"Varronia curassavica has anti-inflammatory properties because of the terpenes, α-humulene and β-caryophyllene, present in the essential oil. The objective of this study was to evaluate the influence of seasonality on the essential oil of V. curassavica accessions. Leaves from six accessions were collected from the Germplasm Bank of the Federal University of Minas Gerais over 12 months. Correlations between the essential oil content and meteorological factors were determined. Gas chromatography analysis coupled with mass spectrometry was conducted to determine the chemical composition of the essential oil. The content and chemical composition of the oil varied throughout the year. Relative humidity was correlated with accessions ICA-VC2 (-0.64) and ICA-VC4 (0.68). β-bourbonene, β-elemene, spathulenol, germacrene, caryophyllene oxide, α-humulene, and β-caryophyllene occurred in all accessions. Accession ICA-VC3 exhibited lower variation (22.17%), higher average (0.97%) essential oil, and maintained an average abundance of α-humulene greater than 2.6%, which is the amount necessary for phytotherapeutics.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76251829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.47
Syed Ali Raza, Maqsood Ahmad, M. Mumtaz, Sadia Bashir, A. Rashid
Search for safe antioxidants and novel nutraceuticals urged to evaluate the antioxidant, anti-acetylcholine esterase and anti-lipoxygenase activity of various leaf extracts of Conocarpus lancifolius. Extraction was optimized from freeze dried plant extracts quenched with liquid nitrogen using water, ethanol, methanol, hexane, ethyl acetate and chloroform. Maximum extract yield, total phenolic contents and total flavonoid contents were obtained in case of ethanolic extraction. The highest 2,2-diphenyl-1-picrylhydrazylradical scavenging in terms of IC50 value of 55.26 μg/mL was observed for ethanolic leaf extract. The acetylcholine esterase and lipoxygenase inhibitory activities (IC50) were also observed for ethanolic extract. These findings for ethanolic extract were statistically significant when compared with other extracts (ρ<0.05). The haemolytic % values indicated that all extracts were associated with very low or negligible toxicity. The epicatechin, isorhamnetin, rutin, scopoleptin, skimmianine, quercetin-3-O-α-rhamnoside, quercetin-3-O-β-glucoside, cornoside, creatinine, choline, pyruvic acid, α-hydroxybutyric acid, phyllanthin and hypophyllanthin were identified as major functional metabolites in ethanolic leaf extract of C. lancifolius by 1H-NMR. The identified metabolites were probably responsible for the pharmacological properties of C. lancifolius. The findings may be utilized as pharmacological leads for drug development and food fortification.
寻找安全的抗氧化剂和新型的营养保健品，评价不同叶提取物的抗氧化、抗乙酰胆碱酯酶和抗脂氧化酶活性。以水、乙醇、甲醇、己烷、乙酸乙酯和氯仿为溶剂，用液氮淬火冷冻干燥植物提取物，优化提取工艺。以乙醇为萃取剂，提取率、总酚含量和总黄酮含量最高。乙醇叶提取物对2,2-二苯基-1-苦味肼基自由基的清除能力最高，IC50值为55.26 μg/mL。同时观察了乙醇提取物对乙酰胆碱酯酶和脂氧合酶的抑制活性(IC50)。与其他提取物相比，乙醇提取物的这些结果具有统计学意义(ρ<0.05)。溶血%值表明，所有提取物的毒性都很低或可以忽略不计。经1H-NMR鉴定，表儿茶素、异鼠李素、芦丁、东莨菪碱、脂氨酸、槲皮素-3- o -α-鼠李糖苷、槲皮素-3- o -β-葡萄糖苷、车茱萸苷、肌酐、胆碱、丙酮酸、α-羟基丁酸、叶黄素和次叶黄素是山茱萸乙醇叶提取物的主要功能代谢物。鉴定的代谢物可能是导致金针叶药理特性的原因。这些发现可以作为药物开发和食品强化的药理学线索。
{"title":"Atributos farmacológicos in vitro y huellas dactilares de metabolitos de Conocarpus lancifolius","authors":"Syed Ali Raza, Maqsood Ahmad, M. Mumtaz, Sadia Bashir, A. Rashid","doi":"10.37360/BLACPMA.21.20.6.47","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.47","url":null,"abstract":"Search for safe antioxidants and novel nutraceuticals urged to evaluate the antioxidant, anti-acetylcholine esterase and anti-lipoxygenase activity of various leaf extracts of Conocarpus lancifolius. Extraction was optimized from freeze dried plant extracts quenched with liquid nitrogen using water, ethanol, methanol, hexane, ethyl acetate and chloroform. Maximum extract yield, total phenolic contents and total flavonoid contents were obtained in case of ethanolic extraction. The highest 2,2-diphenyl-1-picrylhydrazylradical scavenging in terms of IC50 value of 55.26 μg/mL was observed for ethanolic leaf extract. The acetylcholine esterase and lipoxygenase inhibitory activities (IC50) were also observed for ethanolic extract. These findings for ethanolic extract were statistically significant when compared with other extracts (ρ<0.05). The haemolytic % values indicated that all extracts were associated with very low or negligible toxicity. The epicatechin, isorhamnetin, rutin, scopoleptin, skimmianine, quercetin-3-O-α-rhamnoside, quercetin-3-O-β-glucoside, cornoside, creatinine, choline, pyruvic acid, α-hydroxybutyric acid, phyllanthin and hypophyllanthin were identified as major functional metabolites in ethanolic leaf extract of C. lancifolius by 1H-NMR. The identified metabolites were probably responsible for the pharmacological properties of C. lancifolius. The findings may be utilized as pharmacological leads for drug development and food fortification.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75947171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.42
A. Oseni, O. Olusola-Makinde, M. Oladunmoye
This study investigated the antibacterial potential of Euphorbia hirta whole plant extracts, honey and conventional antibiotics and their synergistic effects against selected multidrug resistant and typed bacterial strains associated with otitis media. E. hirta whole plant extract was purified using column chromatography technique. The antibacterial assays of extracts were done using standard microbiological procedures. Protein, sodium and potassium ion leakage of the synergistic mixtures was determined using flame-photometry. At 100 mg/ml, acetone extracts presented highest inhibition against S. aureus (NCTC 6571) with 32 ± 0.83 mm zone of inhibition. The fractional inhibitory concentration indices displayed higher synergism in combination of plant extract, honey and ciprofloxacin against P. mirabilis at 0.02 compared to drug combination synergy standard (≤ 0.5). This work revealed augmentation of ciprofloxacin potency when combined with purified E. hirta acetone extract and honey and implies their high potential in the treatment of multidrug resistant infection of otitis media.
{"title":"Structural elucidation, mechanism of action, antibacterial proficiency and synergistic forte of purified Euphorbia hirta whole plant extract against multi-drug resistant otitis media infection","authors":"A. Oseni, O. Olusola-Makinde, M. Oladunmoye","doi":"10.37360/BLACPMA.21.20.6.42","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.42","url":null,"abstract":"This study investigated the antibacterial potential of Euphorbia hirta whole plant extracts, honey and conventional antibiotics and their synergistic effects against selected multidrug resistant and typed bacterial strains associated with otitis media. E. hirta whole plant extract was purified using column chromatography technique. The antibacterial assays of extracts were done using standard microbiological procedures. Protein, sodium and potassium ion leakage of the synergistic mixtures was determined using flame-photometry. At 100 mg/ml, acetone extracts presented highest inhibition against S. aureus (NCTC 6571) with 32 ± 0.83 mm zone of inhibition. The fractional inhibitory concentration indices displayed higher synergism in combination of plant extract, honey and ciprofloxacin against P. mirabilis at 0.02 compared to drug combination synergy standard (≤ 0.5). This work revealed augmentation of ciprofloxacin potency when combined with purified E. hirta acetone extract and honey and implies their high potential in the treatment of multidrug resistant infection of otitis media.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85503956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.46
R. C. Oliveira, Jarbas dos Reis Silva, J. M. Luz, A. Blank, T. Sampaio, S. Silva
The objective was to evaluate the production and composition of lavender essential oil, simultaneously at open field and greenhouse, in spring-summer season, under different types of fertilization. Each cultivation system was considered an experiment (field and greenhouse), and in both, the experimental design used was randomized blocks, with five treatments, being fertilization with nutrient source - 100% mineral (100% M), 100% organic (100% O), 100% organomineral (100% OM), 50% organomineral (50% OM), and without fertilization (control), and three repetitions. Better performance and productivity of Lavandula dentata is related to respectively 100% OM and 50% OM fertilization in the field and greenhouse. The essential oil content does not differ between cultivation systems and kind of fertilizers, and the majorities compounds were 1.8-cineol, fenchone and camphor.
{"title":"Production and composition of Lavender oil: nutritional management and cultivation systems","authors":"R. C. Oliveira, Jarbas dos Reis Silva, J. M. Luz, A. Blank, T. Sampaio, S. Silva","doi":"10.37360/BLACPMA.21.20.6.46","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.46","url":null,"abstract":"The objective was to evaluate the production and composition of lavender essential oil, simultaneously at open field and greenhouse, in spring-summer season, under different types of fertilization. Each cultivation system was considered an experiment (field and greenhouse), and in both, the experimental design used was randomized blocks, with five treatments, being fertilization with nutrient source - 100% mineral (100% M), 100% organic (100% O), 100% organomineral (100% OM), 50% organomineral (50% OM), and without fertilization (control), and three repetitions. Better performance and productivity of Lavandula dentata is related to respectively 100% OM and 50% OM fertilization in the field and greenhouse. The essential oil content does not differ between cultivation systems and kind of fertilizers, and the majorities compounds were 1.8-cineol, fenchone and camphor.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84748297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-07-13DOI: 10.37360/BLACPMA.21.20.6.45
G. Zuluaga, Juan Pimentel, Iván Sarmiento, Neil Andersson
The prevalence, morbidity and costs of asthma care have increased worldwide. This study describes the effect and safety of an outpatient medical treatment with traditional medicine for asthma, through a retrospective case series with patients admitted to outpatient consultation from 1995 to 2015 in Cota, Colombia. Analyzing 26 cases with a clinical diagnosis of asthma, during the treatment 34.6% (9/26) did not present episodes of uncontrolled asthma and 61.5% (16/26) were classified as controlled asthma in their last consultation of control. 88.4% (23/26) of the patients reported no adverse reactions and the three reported were mild. The results allow to generate hypotheses about the effectiveness and safety of an outpatient treatment based on the incorporation of resources from traditional medicine. These observations could be explored with experimental studies to determine their long-term effectiveness, safety and low cost.
{"title":"Efecto y seguridad de un tratamiento ambulatorio de medicina tradicional para el asma en 26 pacientes de cota, colombia: Una serie de casos","authors":"G. Zuluaga, Juan Pimentel, Iván Sarmiento, Neil Andersson","doi":"10.37360/BLACPMA.21.20.6.45","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.6.45","url":null,"abstract":"The prevalence, morbidity and costs of asthma care have increased worldwide. This study describes the effect and safety of an outpatient medical treatment with traditional medicine for asthma, through a retrospective case series with patients admitted to outpatient consultation from 1995 to 2015 in Cota, Colombia. Analyzing 26 cases with a clinical diagnosis of asthma, during the treatment 34.6% (9/26) did not present episodes of uncontrolled asthma and 61.5% (16/26) were classified as controlled asthma in their last consultation of control. 88.4% (23/26) of the patients reported no adverse reactions and the three reported were mild. The results allow to generate hypotheses about the effectiveness and safety of an outpatient treatment based on the incorporation of resources from traditional medicine. These observations could be explored with experimental studies to determine their long-term effectiveness, safety and low cost.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73069237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To investigate effectsof Yangyinyiqi Mixture on pulmonary fibrosis caused by bleomycin. SD ratswere divided randomly into: model group(distilled water,1 mL·0.1 kg-1), dexamethasone acetate group(dexamethasone acetate, the dosage was reduced gradually), low-dose group(Yangyinyiqi Mixture, 11 g·kg-1), moderate-dose group(Yangyinyiqi Mixture, 22 g·kg-1), high-dose group (Yangyinyiqi Mixture, 44 g·kg-1) and control group(distilled water, 1 mL·0.1 kg-1). Yangyinyiqi Mixture and dexamethasone acetate were intragastrically administrated. Lung tissue was collected for histopathological examination. Compared with control group, collagen markedly increased andHYP content significantly increased on 7th day in model group (p<0.01). On 28th day, collagen was diffusely deposited, alveolar was destroyed, and HYP content significantly increased (p<0.01). Compared with model group, bleomycin-induced suffering injury caused MMP-9 expression levels to rapidly increase (7and 14 days, p<0.01). TIMP-1 markedly increased (7and 14 days, p<0.01) and stayed at a high levelto28th day. Yangyinyiqi Mixture exerted an effect against pulmonary fibrosis, which could involved prevention of collagen deposition through inhibitingMMP-9 and TIMP-1 expression.
{"title":"The study of Yangyinyiqi mixture anti bleomycin-induced pulmonary fibrosis on rats by intervening matrix metalloproteinase-9 and tissue inhibitors of matrix metalloproteinases-1","authors":"Hong Wang, Chen-Yu Chen, Yong Zhu, Jicheng Zhou, Wen-zhen Yin, Zhiyuan Li, Xuefeng Yang, Xinkai Qiu","doi":"10.37360/BLACPMA.21.20.3.23","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.3.23","url":null,"abstract":"To investigate effectsof Yangyinyiqi Mixture on pulmonary fibrosis caused by bleomycin. SD ratswere divided randomly into: model group(distilled water,1 mL·0.1 kg-1), dexamethasone acetate group(dexamethasone acetate, the dosage was reduced gradually), low-dose group(Yangyinyiqi Mixture, 11 g·kg-1), moderate-dose group(Yangyinyiqi Mixture, 22 g·kg-1), high-dose group (Yangyinyiqi Mixture, 44 g·kg-1) and control group(distilled water, 1 mL·0.1 kg-1). Yangyinyiqi Mixture and dexamethasone acetate were intragastrically administrated. Lung tissue was collected for histopathological examination. Compared with control group, collagen markedly increased andHYP content significantly increased on 7th day in model group (p<0.01). On 28th day, collagen was diffusely deposited, alveolar was destroyed, and HYP content significantly increased (p<0.01). Compared with model group, bleomycin-induced suffering injury caused MMP-9 expression levels to rapidly increase (7and 14 days, p<0.01). TIMP-1 markedly increased (7and 14 days, p<0.01) and stayed at a high levelto28th day. Yangyinyiqi Mixture exerted an effect against pulmonary fibrosis, which could involved prevention of collagen deposition through inhibitingMMP-9 and TIMP-1 expression.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73482598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-30DOI: 10.37360/BLACPMA.21.20.3.24
N. Lima, T. O. Falcoski, R. S. Silveira, Haustin S Vieira, Vanessa N C Santos, R. R. Ramos, J. C. D. Silva, T. Andrade, A. Carli, P. Costa, F. L. La Porta, M. V. Almeida
In this present study, we investigated the influence of various extraction methods including maceration, sonication, infusion, decoction, and microwave extraction, on the chemical and biological potential of phytochemicals extracted from three medicinal plants (Ageratum conyzoides, Plantago major and Arctium lappa L). The results were subsequently analyzed by variance analysis. Our results suggested that sonication is the most effective extraction method among the five methods tested herein, for the extraction of phytochemicals that have a high antioxidant potential and high phenolic content. The three plants employed for this study had a high concentration of flavonoids and phenolics which was compatible with the chemosystematics of the species. All the samples possessed a Sun Protection Factor (SPF) of less than 6. Interestingly, a maximum reaction time of approximately 20 min was noted for the complexation of AlCl3with the flavonoids present in the phytochemical extract during analyses of the kinetic parameters. We finally identified that the Ageratum conyzoides extract, prepared by sonication, possessed a significant pharmacological potential against hepatocarcinoma tumour cells, whose result can guide further studies for its therapeutic efficacy.
{"title":"Effectiveness of different methods for the extraction of principle actives and phytochemicals content in medicinal herbals","authors":"N. Lima, T. O. Falcoski, R. S. Silveira, Haustin S Vieira, Vanessa N C Santos, R. R. Ramos, J. C. D. Silva, T. Andrade, A. Carli, P. Costa, F. L. La Porta, M. V. Almeida","doi":"10.37360/BLACPMA.21.20.3.24","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.3.24","url":null,"abstract":"In this present study, we investigated the influence of various extraction methods including maceration, sonication, infusion, decoction, and microwave extraction, on the chemical and biological potential of phytochemicals extracted from three medicinal plants (Ageratum conyzoides, Plantago major and Arctium lappa L). The results were subsequently analyzed by variance analysis. Our results suggested that sonication is the most effective extraction method among the five methods tested herein, for the extraction of phytochemicals that have a high antioxidant potential and high phenolic content. The three plants employed for this study had a high concentration of flavonoids and phenolics which was compatible with the chemosystematics of the species. All the samples possessed a Sun Protection Factor (SPF) of less than 6. Interestingly, a maximum reaction time of approximately 20 min was noted for the complexation of AlCl3with the flavonoids present in the phytochemical extract during analyses of the kinetic parameters. We finally identified that the Ageratum conyzoides extract, prepared by sonication, possessed a significant pharmacological potential against hepatocarcinoma tumour cells, whose result can guide further studies for its therapeutic efficacy.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88693107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-30DOI: 10.37360/BLACPMA.21.20.3.17
Martha Quiteria Silva Henriques, D. H. X. Barbosa, D. N. Alves, Ana Karoline Vieira Melo, Ricardo Dias de Castro
This review describes the geographical distribution, botanical data, popular use, chemical composition, pharmacological activities and genetic aspects related to Eugenia luschnathiana, a native Brazilian plant popularly known as “bay pitomba”. E. luschnathianaleaves are characterized morphologically by the presence of a petiole, an attenuated base, acuminated apex, elliptical shape, and parallel venation. The major chemical compounds found in E. luschnathiana are sesquiterpenes. Literature reports showed that E. luschnathianaextracts have antioxidant properties and antimicrobial activity against Gram-negative and Gram-positive bacteria. The extractsfrom the leaf, fruit and stem, and a concentrated residual solution of its essential oil, displayed negligible toxicity. Lastly, a cytogenetic analysis indicated that some markers can be used for the study of genetic diversity, population structure, and genetic improvements. The information available on E. luschnathianasupports the hypothesis that this plant may be a source of compounds with promising pharmacological activity.
{"title":"Chemical composition, antioxidant, antimicrobial activity, toxicity, genetic analysis and popular use of Eugenia luschnathiana(O. Berg) Klotzsch ex B.D.Jacks: a literature review","authors":"Martha Quiteria Silva Henriques, D. H. X. Barbosa, D. N. Alves, Ana Karoline Vieira Melo, Ricardo Dias de Castro","doi":"10.37360/BLACPMA.21.20.3.17","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.3.17","url":null,"abstract":"This review describes the geographical distribution, botanical data, popular use, chemical composition, pharmacological activities and genetic aspects related to Eugenia luschnathiana, a native Brazilian plant popularly known as “bay pitomba”. E. luschnathianaleaves are characterized morphologically by the presence of a petiole, an attenuated base, acuminated apex, elliptical shape, and parallel venation. The major chemical compounds found in E. luschnathiana are sesquiterpenes. Literature reports showed that E. luschnathianaextracts have antioxidant properties and antimicrobial activity against Gram-negative and Gram-positive bacteria. The extractsfrom the leaf, fruit and stem, and a concentrated residual solution of its essential oil, displayed negligible toxicity. Lastly, a cytogenetic analysis indicated that some markers can be used for the study of genetic diversity, population structure, and genetic improvements. The information available on E. luschnathianasupports the hypothesis that this plant may be a source of compounds with promising pharmacological activity.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81127994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-30DOI: 10.37360/BLACPMA.21.20.3.19
C. D. da Câmara, C. A. D. de Araújo, M. D. de Moraes, J. D. de Melo, M. F. A. Lucena
Essential oils from the leaves and stems of Croton adenocalyx, C. grewioides, C. heliotropiifoliusand C. blanchetianusobtained through hydrodistillation were analyzed by GC-MS. We then investigated the lethal and sublethal effects of the Croton oils and 15 major constituents against Tetranychus urticae. β-Caryophyllene was the major component in the leaf and stem oils from C. heliotropiifoliusand C. adenocalyx. Spathulenol and (E)-anethole were the major constituents identified in the leaf and stem oils of C. blanchetianusand C. grewioides, respectively. The oil with the greatest lethal and sublethal effects was those from C. adenocalyx. Among the constituents β-caryophyllene and spatulenol were the most toxic to the mite, whereas eugenol and methyl eugenol were the most repellent. The toxicity and repellency of the Croton oils, particularly the oils from C. adenocalyx, demonstrate that these oils constitute a promising alternative to synthetic acaricides for use in the control of T. urticae.
采用气相色谱-质谱联用技术对巴豆(Croton adenocalyx, C. grewioides, C. heliotropiifoliusand C. blanchetianus4种植物)的叶、茎挥发油进行了分析。研究了巴豆油和15种主要成分对荨麻疹叶螨的致死和亚致死作用。β-石竹烯是石竹叶油和石竹茎油的主要成分。在白桦叶油和藤茎油中分别鉴定出Spathulenol和(E)-anethole。致死和亚致死作用最大的油为腺萼菊油。其中，β-石竹烯和铲烯醇对螨的毒性最大，而丁香酚和甲基丁香酚对螨的驱避作用最大。巴豆油的毒性和驱避性，特别是对巴豆油的毒性和驱避性，表明巴豆油是一种很有前途的替代合成杀螨剂用于防治荨麻疹的方法。
{"title":"New sources of botanical acaricides from species of Croton with potential use in the integrated management of Tetranychus urticae","authors":"C. D. da Câmara, C. A. D. de Araújo, M. D. de Moraes, J. D. de Melo, M. F. A. Lucena","doi":"10.37360/BLACPMA.21.20.3.19","DOIUrl":"https://doi.org/10.37360/BLACPMA.21.20.3.19","url":null,"abstract":"Essential oils from the leaves and stems of Croton adenocalyx, C. grewioides, C. heliotropiifoliusand C. blanchetianusobtained through hydrodistillation were analyzed by GC-MS. We then investigated the lethal and sublethal effects of the Croton oils and 15 major constituents against Tetranychus urticae. β-Caryophyllene was the major component in the leaf and stem oils from C. heliotropiifoliusand C. adenocalyx. Spathulenol and (E)-anethole were the major constituents identified in the leaf and stem oils of C. blanchetianusand C. grewioides, respectively. The oil with the greatest lethal and sublethal effects was those from C. adenocalyx. Among the constituents β-caryophyllene and spatulenol were the most toxic to the mite, whereas eugenol and methyl eugenol were the most repellent. The toxicity and repellency of the Croton oils, particularly the oils from C. adenocalyx, demonstrate that these oils constitute a promising alternative to synthetic acaricides for use in the control of T. urticae.","PeriodicalId":17966,"journal":{"name":"Latin American and Caribbean Bulletin of Medicinal and Aromatic Plants","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80606373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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