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Insulin analogs versus human insulins for the management of diabetes: An evidence-based review 胰岛素类似物与人胰岛素治疗糖尿病:循证综述
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_96_20
M. Eledrisi
Insulin analogs are preferred by many physicians over human insulins in the management of Type 1 diabetes and in patients with Type 2 diabetes who require insulin. Insulin analogs have a pharmacological profile that is close to the normal physiological action of insulin. There is a notion among some clinicians that insulin analogs offer advantages over human insulins, including better glucose control, less hypoglycemia, and flexibility. A large number of clinical studies, along with systematic reviews, have compared insulin analogs to human insulins in regard to glucose control, rates of hypoglycemia, quality of life, and cost-effectiveness. For Type 1 diabetes, rapid-acting insulin analogs offer better glucose control and less rates of hypoglycemia compared to regular human insulin. Long-acting basal insulins result in less nocturnal hypoglycemia compared to neutral protamine Hagedorn (NPH) insulin but no difference in glucose control in patients with Type 1 diabetes. For patients with Type 2 diabetes, rapid-acting insulins offer no advantage for glucose control or rates of hypoglycemia when compared to regular insulin. There was only a reduction in rates of nocturnal hypoglycemia with no difference in glucose control with the use of basal insulin analogs compared to NPH insulin in Type 2 diabetes. The cost of insulin analogs is considerably higher than human insulins and favorable cost-effectiveness was only demonstrated with rapid-acting insulin analogs in Type 1 diabetes. The available evidence does not support the routine use of insulin analogs over human insulins. There are only few situations where insulin analogs have shown clear benefit over human insulin. In a large percentage of patients cost consideration and lack of better glucose control would favor the use of human insulins.
在1型糖尿病和需要胰岛素治疗的2型糖尿病患者中,许多医生更喜欢胰岛素类似物而不是人胰岛素。胰岛素类似物具有接近胰岛素正常生理作用的药理学特征。一些临床医生认为胰岛素类似物比人用胰岛素更有优势,包括更好的血糖控制、更少的低血糖和灵活性。大量的临床研究和系统综述比较了胰岛素类似物与人类胰岛素在血糖控制、低血糖率、生活质量和成本效益方面的差异。对于1型糖尿病,速效胰岛素类似物与常规人用胰岛素相比,能更好地控制血糖,降低低血糖率。与中性鱼精蛋白Hagedorn (NPH)胰岛素相比,长效基础胰岛素导致较少的夜间低血糖,但在1型糖尿病患者的血糖控制方面没有差异。对于2型糖尿病患者,与常规胰岛素相比,速效胰岛素在血糖控制或低血糖率方面没有优势。在2型糖尿病患者中,使用基础胰岛素类似物与使用NPH胰岛素相比,夜间低血糖发生率只有降低,血糖控制没有差异。胰岛素类似物的成本比人用胰岛素高得多,只有在治疗1型糖尿病的速效胰岛素类似物中才显示出良好的成本效益。现有的证据不支持常规使用胰岛素类似物而不是人胰岛素。只有在少数情况下,胰岛素类似物显示出明显优于人类胰岛素。在很大比例的患者中,考虑到成本和缺乏更好的血糖控制,倾向于使用人胰岛素。
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引用次数: 1
SARS-CoV-2 infection associated-meningoencephalitis treated with acyclovir 用阿昔洛韦治疗SARS-CoV-2感染相关脑膜脑炎
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_97_20
Mohammad N. Kloub, Mousa Alhiyari, Jabeed Parengal, Elmahdi Errayes, M. Yassin
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infection is now a pandemic distributed worldwide. All age groups are susceptible to infection, the elderly population, and those with a background of chronic medical comorbidities being particularly vulnerable for severe symptoms and complicated outcome. SARS-CoV-2 infection mainly targets the respiratory system and can establish infection in the upper part of the respiratory tract as well as the lower part of the respiratory tract, presenting in a spectrum ranging from asymptomatic infection reaching up to severe acute respiratory distress syndrome; however, the viral infection is not solely confined to the respiratory system as many cases have been reported where the patients present with different bodily system symptoms without having respiratory symptoms as usual. We report a 51-year old male who presented with symptoms of fever and dry cough and was diagnosed as a case of COVID-19 pneumonia that was later complicated by meningoencephalitis. The patient underwent diagnostic neuroimaging and lumbar puncture; patient received therapy with intravenous acyclovir and intravenous ceftraixone and improved with a favorable outcome. Meningioencephalitis is a serious neurological complication of SARS-CoV-2 infection and should be suspected in patients who develop signs and symptoms suggesting this condition, and we aim from publishing this case to draw attention to this serious complication.
严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)感染现已成为全球范围内的大流行。所有年龄组都易受感染,老年人和有慢性合并症背景的人特别容易出现严重症状和复杂的结果。SARS-CoV-2感染主要针对呼吸系统,可在呼吸道上半部分和下半部分建立感染,表现为从无症状感染到严重急性呼吸窘迫综合征;然而,病毒感染并不仅仅局限于呼吸系统,因为已有许多病例报告,患者表现出不同的身体系统症状,而不像通常那样有呼吸道症状。我们报告了一名51岁男性,他出现发烧和干咳症状,被诊断为COVID-19肺炎病例,后来并发脑膜脑炎。患者接受了诊断性神经影像学检查和腰椎穿刺;患者接受静脉注射阿昔洛韦和静脉注射头孢曲松治疗,病情好转,预后良好。脑膜脑炎是SARS-CoV-2感染的严重神经系统并发症,在出现体征和症状的患者中应加以怀疑,我们发表这一病例的目的是引起人们对这一严重并发症的关注。
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引用次数: 0
Medical waste management in dental clinics in Tripoli/Libya 的黎波里/利比亚牙科诊所的医疗废物管理
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_25_20
Rema Shampe, Raga A. Elzahaf, M. Al-Jaghbir, A. Battah
Background: Dental clinics are important and essential for the health and safety of individuals in the community and they are indispensable for the provision of medical and therapeutic services for the diagnosis of oral diseases, gum and teeth. As important as the other health centers, good and appropriate management of medical waste in dental clinics is very important to ensure safety for staff in the clinic. Objectives: Evaluating the level of medical waste management in dental clinics in Tripoli/ Libya. Methods: A cross-sectional study was conducted on 201 respondents: dentists, nurses, and assistants dentist chosen from 67 clinics out of 135 clinics. A questionnaire was used to two sections. The data were analyzed by using the IBM Statistical Package for Social Sciences (IBM SPSS) software, version 19.0 (SPSS Inc.). Results: 39.8% of respondents who were separating contaminated blood from non-contaminated waste and 82.1% of respondent's disposal liquid waste such as blood and saliva through the sewage network. However, there was no statistically significant difference in medical waste management between male and female dental staff in Tripoli, Libya (t = 0.376, P = 0.170). Conclusions: The methods of medical waste management practiced in the most dental clinics were inappropriate. The study demonstrated that there was lack of knowledge among workers in dental clinics regarding the disposal procedures and dealing with waste. Therefore, it is necessary to re-assess safety protocols by authorities and intervene quickly by introducing spread awareness of health and safety in dental clinics and in forcing regulations.
背景:牙科诊所对社会上个人的健康和安全至关重要,而且在提供诊断口腔疾病、牙龈和牙齿的医疗和治疗服务方面也是不可或缺的。与其他保健中心一样重要的是,对牙科诊所的医疗废物进行良好和适当的管理对于确保诊所工作人员的安全非常重要。目标:评估利比亚的黎波里牙科诊所医疗废物管理水平。方法:采用横断面研究对来自135个诊所中的67个诊所的201名受访牙医、护士和助理牙医进行调查。问卷分为两部分。采用IBM SPSS 19.0版社会科学统计软件包(IBM SPSS)软件(SPSS Inc.)进行数据分析。结果:39.8%的受访者将受污染的血液与未受污染的废物进行分离,82.1%的受访者通过污水管网处理血液、唾液等液体废物。然而,在利比亚的黎波里,男性和女性牙科工作人员在医疗废物管理方面没有统计学上的显著差异(t = 0.376, P = 0.170)。结论:大多数牙科诊所的医疗废物管理方法不合理。研究表明,牙科诊所的工作人员缺乏关于废物处置程序和处理的知识。因此,有必要重新评估当局的安全协议,并通过在牙科诊所普及健康和安全意识和强制法规迅速进行干预。
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引用次数: 0
A rare cause of hypocalcemia: Hypoparathyroidism, sensorineural deafness, and renal disease syndrome 低钙症的罕见病因:甲状旁腺功能减退症、感音神经性耳聋和肾脏疾病综合征
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_81_20
S. Benamer, P. Jennings
Hypocalcemia is a common electrolyte disturbance with a variety of causes. Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) syndrome is a rare autosomal-dominant genetic disorder characterized by hypoparathyroidism, sensorineural deafness, and renal disease. This is a case presentation of HDR syndrome that had been referred to a hospital with hypocalcemia. This case has a unique feature as it has been diagnosed in adult age because usually HDR syndrome is diagnosed in pediatric age group.
低钙血症是一种常见的电解质紊乱,有多种原因。甲状旁腺功能减退、感音神经性耳聋和肾脏疾病(HDR)综合征是一种罕见的常染色体显性遗传病,以甲状旁腺功能减退、感音神经性耳聋和肾脏疾病为特征。这是一个HDR综合征的病例,因低钙血症被转诊到医院。由于HDR综合征通常在儿童年龄组被诊断,本病例的独特之处在于它已被诊断为成人。
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引用次数: 0
Variation in the branching pattern of the anterior branches of the external carotid artery 颈外动脉前支分支形态的变化
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_53_20
M. Elsllabi, S. Garoushi, K. Aneiba, O. Tashani
Background/Aim: External carotid artery (ECA) shows a variable branching pattern of its stemming vessels. The aim of this study was to investigate the variations in the origin of the three primary anterior branches of the ECA: superior thyroid artery (STA), lingual artery (LA), and facial artery (FA). Methods: The branching pattern of the ECA was studied on 15 Thiel embalmed cadavers of Scottish population (7 males and 8 females). The carotid triangle was dissected bilaterally to uncover the common carotid artery (CCA), internal carotid artery and ECA. The level of carotid artery bifurcation (CB) was located. Variation of the branching patterns of the ECA was assessed. Moreover, the distances between the origin sites of these vessels and the site of the CB were measured. Results: The STA was found to arise more frequently from the ECA (60%) than from the CCA (40%), with no differences in distribution between sexes or sides. Regarding the assessment of the branching patterns of the ECA, the specimens where the STA, LA, and FA emerged as individual branches were 90% of cases, linguofacial trunk cases were 6.7%, and thyrolinguofacial trunk cases were 3.3%. The distances from the vessel origin site to the CB were found to be 8.11 ± 2.77 mm, 19.38 ± 8.85 mm, and 27.95 ± 10.15 mm, for the STA, LA, and FA, respectively. Conclusions: The current findings have confirmed that the ECA branching pattern is highly variable in Thiel embalmed cadavers of Scottish population. Therefore, considering some radiological imaging before conducting any invasive procedure in the neck region could be vital to prevent iatrogenic injuries.
背景/目的:颈外动脉(ECA)显示出其干血管的可变分支模式。本研究的目的是研究ECA的三个主要前支起源的变化:甲状腺上动脉(STA),舌动脉(LA)和面动脉(FA)。方法:对15具苏格兰蒂尔防腐尸体(男7例,女8例)进行ECA分支模式研究。双侧切开颈动脉三角,显露颈总动脉(CCA)、颈内动脉和ECA。确定颈动脉分岔水平。评估了ECA分支模式的变化。此外,测量了这些血管的起源位置与CB位置之间的距离。结果:STA发生在ECA(60%)比CCA(40%)更频繁,在性别或侧方之间的分布没有差异。对于ECA分支形态的评估,STA、LA和FA作为单个分支出现的标本占90%,舌面干占6.7%,甲状腺舌面干占3.3%。STA、LA和FA从血管起源部位到CB的距离分别为8.11±2.77 mm、19.38±8.85 mm和27.95±10.15 mm。结论:目前的研究结果证实,在苏格兰人群的Thiel防腐尸体中,ECA分支模式是高度可变的。因此,在对颈部进行任何侵入性手术之前,考虑一些放射成像对于预防医源性损伤至关重要。
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引用次数: 1
Assessment of patient safety culture in benghazi children's hospital from the viewpoint of nursing staff 从护理人员的角度评价班加西儿童医院患者安全文化
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_79_20
Ainas Eltarhuni, Hajir Tawfeeq, Jebril El-Abidi
Background: patient safety is a critical component of health-care quality, and it is considered as an important issue worldwide. This study aimed to assess patient safety culture (PSC) among nurses and to investigate the areas of deficiencies for improvement. Methods: A descriptive cross-sectional study was conducted on nurses working at Benghazi Children's Hospital. A self-administered questionnaire containing 12 dimensions was used to assess the Hospital Survey on PSC including patient safety grade and number of events reported. Results: Only 87 of the total 118 distributed questionnaires were returned, giving a response rate of 73.7%. The overall positive response rate of PSC was 47%. The dimension with the highest positive score and considered areas of strength were teamwork within units (72%). The dimension with the lowest percentage of positive response rate was nonpunitive response to error (30%). Conclusion: Improving PSC should be a priority among hospital administrators. Staff should be encouraged to report errors spontaneously and without any fear.
背景:患者安全是卫生保健质量的一个重要组成部分,在世界范围内被视为一个重要问题。本研究旨在评估护士的病人安全文化(PSC),并调查需要改进的不足之处。方法:对班加西儿童医院护士进行描述性横断面研究。一份包含12个维度的自我管理问卷用于评估医院对PSC的调查,包括患者安全等级和报告的事件数量。结果:发放问卷118份,回收问卷87份,回复率为73.7%。PSC的总阳性反应率为47%。正面得分最高的维度和被认为具有优势的领域是单位内部的团队合作(72%)。正面回应率最低的维度是错误非惩罚性回应(30%)。结论:提高PSC应成为医院管理者的首要任务。应鼓励工作人员自发地、毫无畏惧地报告错误。
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引用次数: 0
Environmental practices and serum Vitamin D deficiency 环境实践与血清维生素D缺乏
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_102_20
M. Danjuma
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引用次数: 0
Provision of pharmaceutical services in time of COVID-19 crisis: A libyan vision 在2019冠状病毒病危机期间提供药品服务:利比亚的愿景
Pub Date : 2020-10-01 DOI: 10.4103/ljms.ljms_48_20
Amal Y. Benkorah
Pharmaceutical services play a crucial role in any health system. Pharmacists are the main health professionals to ensure that people have access to good and safe medicines and to make certain that these medicines are used rationally. While the role of pharmacists in providing health-care services in Libya remains restricted, the scope of pharmacy practice is vast and encompasses a variety of roles and functions. Most of today's pharmacists' services are oriented toward clinical outcomes using medicines. Therefore, pharmacists are focusing on optimizing the use of medications, promoting health, wellness, and preventing diseases. Pharmaceutical services are currently being tailored to be event driven to fit the current COVID-19 pandemic crisis and to help combat this disease and its consequences. This article discusses different pharmaceutical services that can be provided by pharmacists in all practice settings, for the Libyan healthcare system and to the society in general during COVID-19 crisis.
药品服务在任何卫生系统中都发挥着至关重要的作用。药剂师是确保人们获得良好和安全药物并确保合理使用这些药物的主要卫生专业人员。虽然药剂师在利比亚提供保健服务方面的作用仍然有限,但药房的业务范围很广,包括各种作用和职能。今天大多数药剂师的服务是面向临床结果使用药物。因此,药剂师的重点是优化药物的使用,促进健康,保健和预防疾病。目前正在根据事件驱动调整药品服务,以适应当前的COVID-19大流行危机,并帮助应对这一疾病及其后果。本文讨论了在COVID-19危机期间,药剂师可以在所有实践环境中为利比亚医疗保健系统和整个社会提供的不同药物服务。
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引用次数: 0
A challenging presentation of pyrexia and macroscopic hematuria in a kidney transplant patient 肾移植患者出现发热和肉眼可见的血尿
Pub Date : 2020-07-01 DOI: 10.4103/LJMS.LJMS_17_20
Mohamed O. Ezwaie, Hani Elgahwagi, Najat M Aloshibi, Fatma Rugrug
Kidney transplant kidney transplant (KTx) recipients have increased susceptibility to a spectrum of infections including; bacterial, viral, and fungal pathogens. Many factors contribute to their infection potential risk, in terms of their immunosuppressive state, that result in suppression of their B-and T-lymphocyte repertoire, also to consider certain donor and recipient-related factors, that make them at risk of specific type of infectious complications. In addition kidney transplant patients tolerate poorly infections, which may adversely affect their graft function, by inducing glomerular injury, hence early diagnosis, directed therapy, and careful dosing of antimicrobial agents is of paramount importance in reducing patient's morbidity and mortality. We report a kidney transplant patient, who received her live related kidney graft 7 years earlier (in 2013), she has been with stable graft function in most of her follow up period, until she presented with pyrexia, dyspnea and fatigue associated with deterioration of her graft function.
肾移植肾移植(KTx)接受者对一系列感染的易感性增加,包括;细菌、病毒和真菌病原体。许多因素导致他们感染的潜在风险,就他们的免疫抑制状态而言,这导致他们的b和t淋巴细胞库受到抑制,也考虑到某些供体和受体相关因素,使他们面临特定类型的感染并发症的风险。此外,肾移植患者对感染的耐受性较差,这可能会引起肾小球损伤,从而对移植物功能产生不利影响,因此,早期诊断、定向治疗和谨慎使用抗菌药物对降低患者的发病率和死亡率至关重要。我们报告了一位肾移植患者,她于7年前(2013年)接受了活体肾移植,在大部分随访期间,她的移植物功能稳定,直到她出现发热、呼吸困难和疲劳,并伴有移植物功能恶化。
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引用次数: 0
Self-induced anemia secondary to overvalued belief on cupping: A Case report and review of the literature 自致性贫血继发于对拔火罐的高估:1例报告及文献回顾
Pub Date : 2020-07-01 DOI: 10.4103/LJMS.LJMS_45_20
Abdulhak A Sadalla, A. Hussein, Mohammed A Amer
Bloodletting as a treatment for various diseases is an ancient belief; nowadays, it is practiced in many communities, especially in Asia and the Middle East. Among others, cupping is one form of bloodletting procedure. We are presenting a patient with overvalued belief (idea), he relied on cupping as a therapy to treat his headache. For many years, cupping was done for him every few months, then he tried doing it himself, more frequently. Thereafter; cupping sessions dominated his life in a way that he used to do it every few days and whenever he felt a headache. Over the years, the patient sustained severe anemia, although it was self-induced; however, it was not factitious as his intention was to cure himself rather than inducing self-harm. Management was a challenge as it was difficult to convince him to stop this practice and to consult psychiatrist.
放血治疗各种疾病是一种古老的信仰;如今,它在许多社区都有实践,特别是在亚洲和中东。拔火罐是其中一种放血方法。我们给一个病人提供了一个被高估的信念(想法),他依靠拔火罐来治疗他的头痛。多年来,他每隔几个月就会拔火罐一次,后来他自己试着拔火罐,次数越来越多。之后;拔火罐占据了他的生活,他过去每隔几天就会做一次,每当他感到头痛的时候。多年来,患者持续严重的贫血,尽管这是自己引起的;然而,这不是人为的,因为他的意图是治愈自己,而不是引起自残。管理是一个挑战,因为很难说服他停止这种做法并咨询精神科医生。
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引用次数: 0
期刊
Libyan Journal of Medical Sciences
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