Lung Cancer最新文献

{"title":"28 Comparison of Genetic Alteration Concordance Rates: Liquid biopsy vs Conventional biopsy in Non-Small Cell Lung Cancer","authors":"Owoseni Yetunde , Jones Michael , Majmudar Hardil , Mohammad Syed , Sudhir Rajini , Ahmed Samreen , Rahman Ismail , Shaikh Jilaan , Mudiyanselage Dahami , Ganatra Eshaan","doi":"10.1016/j.lungcan.2025.108139","DOIUrl":"10.1016/j.lungcan.2025.108139","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108139"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12 Overview of Large-scale Routine Implementation of Electronic Patient-Reported Outcome Measures (ePROMs) for Patients with Lung Cancer","authors":"Nuamek Thitikorn , Liao Kuan , Taylor Sally , Yorke Janelle , Price James , Faivre-Finn Corinne","doi":"10.1016/j.lungcan.2025.108123","DOIUrl":"10.1016/j.lungcan.2025.108123","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108123"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"97 Later Lines of Chemotherapy in Lung Cancer: Single-Centre Real World Outcomes","authors":"Maynard, Alec Dr , Saxena, Aaruni Dr , Segaran, Avinash Dr , Johnson, Jessica Dr","doi":"10.1016/j.lungcan.2025.108207","DOIUrl":"10.1016/j.lungcan.2025.108207","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108207"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic relevance of inflammatory markers in surgically treated thymic epithelial tumors: An international multicenter study","authors":"Evelyn Megyesfalvi ,&nbsp;Aron Ghimessy ,&nbsp;Jonas Bauer ,&nbsp;Orsolya Pipek ,&nbsp;Kevin Saghi ,&nbsp;Aron Gellert ,&nbsp;Janos Fillinger ,&nbsp;Ozlem Okumus ,&nbsp;Vivien Teglas ,&nbsp;Erna Ganofszky ,&nbsp;Krisztina Bogos ,&nbsp;Ferenc Renyi-Vamos ,&nbsp;Zsolt Megyesfalvi ,&nbsp;Clemens Aigner ,&nbsp;Balazs Hegedus ,&nbsp;Balazs Dome ,&nbsp;Bernhard Moser","doi":"10.1016/j.lungcan.2025.108111","DOIUrl":"10.1016/j.lungcan.2025.108111","url":null,"abstract":"<div><h3>Background</h3><div>Complementary prognostic markers are needed in thymic epithelial tumors (TETs) to aid patient stratification and determine the most appropriate follow-up strategies. This study aimed to assess the diagnostic and prognostic relevance of blood-based inflammatory markers in a large cohort of surgically treated TET patients.</div></div><div><h3>Material and Methods</h3><div>A total of 743 TET patients who underwent surgical resection between 1999–2021 were included in this multicenter study. Inflammatory markers were recorded from the most recent preoperative blood cell count prior to surgery. Measured variables were rescaled and harmonized to obtain comparable values across the participating centers.</div></div><div><h3>Results</h3><div>Preoperative CRP was significantly higher in TET patients with increased tumor size (vs. those with T1 tumors, p = 0.035). Likewise, neutrophil-to-lymphocyte ratio (NLR) (p = 0.002) and platelet-to-lymphocyte ratio (PLR) (p &lt; 0.001) were both significantly higher in thymic carcinomas than in thymomas. Notably, increased NLR and PLR were mainly attributed to significantly decreased lymphocyte levels in thymic carcinoma patients. Concerning survival outcomes, we found that elevated PLR and fibrinogen influenced overall survival (OS) (p = 0.002 and p = 0.018, respectively) and cause-specific survival (CSS) (p = 0.002 and p = 0.009, respectively) independently of other variables in our multivariate models, and they constituted negative prognosticators in TETs. Elevated CRP had an independent negative impact only on OS. Although elevated NLR was linked with impaired prognosis in our univariate model (p = 0.008), its independent prognostic significance could not be validated.</div></div><div><h3>Conclusions</h3><div>Using the so-far largest cohort of surgically treated TET patients, our study demonstrates that CRP, PLR, and NLR have diagnostic significance in TETs, while elevated PLR and fibrinogen constitute independent negative prognosticators for OS and CSS. Accordingly, the current multicenter study offers additional guidance in developing personalized surveillance protocols in thymoma and thymic carcinoma.</div></div>","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108111"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143075013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"51 Staging locally advanced lung cancer using ESMO guidelines: Is it justified?","authors":"Patel Trishna ,&nbsp;Willson Francesca ,&nbsp;McNulty William ,&nbsp;Walder David","doi":"10.1016/j.lungcan.2025.108161","DOIUrl":"10.1016/j.lungcan.2025.108161","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108161"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"64 Removing inequalities in diagnosis of lung cancer with de-novo metastases in England in patients with mental health conditions could prevent almost 2,300 diagnoses with metastases","authors":"Evison Matthew ,&nbsp;Singh Jyotika ,&nbsp;Brown Kieran ,&nbsp;Thomas Stephen ,&nbsp;Fraser Andrew ,&nbsp;Wilson Jodie ,&nbsp;Donovan Lucy ,&nbsp;Coleman Stacey","doi":"10.1016/j.lungcan.2025.108174","DOIUrl":"10.1016/j.lungcan.2025.108174","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108174"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143510395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"69 Real world experience of treatment outcomes comparing ctDNA to tissue NGS in patients with advanced non-small cell lung cancer","authors":"Draicchio Daniella ,&nbsp;Adhikaree Jason ,&nbsp;O'Dowd Emma","doi":"10.1016/j.lungcan.2025.108179","DOIUrl":"10.1016/j.lungcan.2025.108179","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108179"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"13 Further Experiences with the CATCH CT Protocol: Direct Referral for Low-Dose CT Thorax for Low Risk Chest Radiographs","authors":"Khan Bushra ,&nbsp;Sharman Anna ,&nbsp;Greaves Melanie ,&nbsp;Bramley Rhidian","doi":"10.1016/j.lungcan.2025.108124","DOIUrl":"10.1016/j.lungcan.2025.108124","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108124"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"88 Real-world single centre experience of neoadjuvant nivolumab plus chemotherapy in resectable non-small cell lung cancer","authors":"Mehta Ami ,&nbsp;Achim Tabitha ,&nbsp;Su Amanda ,&nbsp;Ahmed Ridwan ,&nbsp;Mawdsley Suzannah ,&nbsp;Dickson Jeanette ,&nbsp;Basu Suprotim ,&nbsp;Denton Arshi ,&nbsp;Antoniou Georgios ,&nbsp;Xhafa-Hamiti Ernese ,&nbsp;Polychronis Andreas ,&nbsp;Dubash Suraiya R","doi":"10.1016/j.lungcan.2025.108198","DOIUrl":"10.1016/j.lungcan.2025.108198","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108198"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"80 Review of malignant pleural mesothelioma patients receiving Nivolumab and Ipilimumab in Northern Ireland (NI) 2022–2024","authors":"Ross Rebekah ,&nbsp;Scullin Paula ,&nbsp;Campbell Lynn","doi":"10.1016/j.lungcan.2025.108190","DOIUrl":"10.1016/j.lungcan.2025.108190","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108190"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143511172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}