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81 Multicentre real-world experience with consolidation durvalumab after chemoradiotherapy in Non-small Cell Lung Cancer: A Five-year Retrospective Study
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108191
Adeoye Femi , Jaffar Nida , Zhang Jufen , Begum Gulshad , Islam Mohammad Rafiqul
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引用次数: 0
11 ‘Cost of a lung cancer diagnosis’: a retrospective audit of the individual financial cost to patients from point of referral to diagnosis in NHS Mid Cheshire.
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108122
Cowie Lewis James , Shallard Georgina , Hughes Rebecca , Fullerton Duncan
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引用次数: 0
Rearranged during transfection (RET) lung cancer – Update on targeted therapies 转染（RET）肺癌中的重排-靶向治疗的最新进展。
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108083
W.J. Mullally , C.G. O’Leary , K.J. O’Byrne
The enhanced comprehension of the molecular pathways underpinning oncogenesis in non-small cell lung cancer (NSCLC) has led to the advancement of personalized treatment for individuals with actionable mutations using targeted therapies. The rearranged during transfection (RET) proto-oncogene, is critical in the embryonic development of various tissues, including renal, neural, and neuroendocrine tissue. RET fusions have been observed in approximately 1–2% of NSCLC cases. Targeted therapies for NSCLC with RET alterations have progressed significantly over the past decade. While multikinase inhibitors (MKIs) faced limitations in efficacy and tolerability, the introduction of selective RET inhibitors (SRIs) such as selpercatininb and pralsetinib has transformed patient outcomes, resulting in deep and durable responses. Ongoing clinical trials are exploring their potential benefits in the neoadjuvant and adjuvant setting. Early phase clinical trials endeavor to demonstrate next-generation selective RET inhibitors can effectively overcome SRI resistance mechanisms, offer improved safety profiles, and enhance patient outcomes.
对非小细胞肺癌（NSCLC）中肿瘤发生的分子通路的深入了解，促进了针对具有可操作突变的个体使用靶向治疗的个性化治疗的进展。转染（RET）过程中原癌基因的重排对包括肾、神经和神经内分泌组织在内的各种组织的胚胎发育至关重要。在大约1-2%的NSCLC病例中观察到RET融合。在过去的十年中，针对RET改变的非小细胞肺癌的靶向治疗取得了显著进展。虽然多激酶抑制剂（MKIs）在疗效和耐受性方面存在局限性，但选择性RET抑制剂（SRIs）如selpercatinb和pralsetinib的引入已经改变了患者的预后，产生了深刻而持久的反应。正在进行的临床试验正在探索它们在新辅助和辅助环境中的潜在益处。早期临床试验努力证明下一代选择性RET抑制剂可以有效克服SRI耐药机制，提供更好的安全性，并提高患者预后。
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引用次数: 0
96 Evaluation of neoadjuvant chemo-immunotherapy for operable Non-Small Cell Lung Cancer
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108206
Mcmahon David , McMahon David , Taher Abu , Hogan Nalinie , Chukwuma Nkem , Amin Nawa , kalofonou Foteini , John Alexius , Milner-Watts Charlotte , Yousaf Nadia , Tan Carol , Smelt Jeremy , Hunt Ian , Jordan Simon , Begum Sofina , Bhosle Jaishree , Minchom Anna , O'Brien Mary , Tokaca Nadza , Popat Sanjay , Davidson Michael
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引用次数: 0
58 Operator outcomes and learning for robotic-assisted bronchoscopic biopsies of pulmonary nodules
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108168
Mullin Monica L , Dunwoody Roisin , Ghattas Sandy , O'Brien Shane , Lansing Meryl , Shea Rosiland , Estenor Danielle , Khiroya Reena , Gorur Pavaan , Navani Neal , Thakrar Ricky
{"title":"58 Operator outcomes and learning for robotic-assisted bronchoscopic biopsies of pulmonary nodules","authors":"Mullin Monica L ,&nbsp;Dunwoody Roisin ,&nbsp;Ghattas Sandy ,&nbsp;O'Brien Shane ,&nbsp;Lansing Meryl ,&nbsp;Shea Rosiland ,&nbsp;Estenor Danielle ,&nbsp;Khiroya Reena ,&nbsp;Gorur Pavaan ,&nbsp;Navani Neal ,&nbsp;Thakrar Ricky","doi":"10.1016/j.lungcan.2025.108168","DOIUrl":"10.1016/j.lungcan.2025.108168","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108168"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
92 Clinical impact and real-world UK multi-center experience of neoadjuvant chemoimmunotherapy for resectable NSCLC
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108202
Milic Marina , Cheung Maggie , Bolnykh Lakov , Newsom-Davis Thomas , Januszewski Adam , Ahmad Tanya , Papadatos-Pastos Dionysis , Lee Siow Ming , Jamal-Hanjani Mariam , Forster Martin , Benafif Sarah
{"title":"92 Clinical impact and real-world UK multi-center experience of neoadjuvant chemoimmunotherapy for resectable NSCLC","authors":"Milic Marina ,&nbsp;Cheung Maggie ,&nbsp;Bolnykh Lakov ,&nbsp;Newsom-Davis Thomas ,&nbsp;Januszewski Adam ,&nbsp;Ahmad Tanya ,&nbsp;Papadatos-Pastos Dionysis ,&nbsp;Lee Siow Ming ,&nbsp;Jamal-Hanjani Mariam ,&nbsp;Forster Martin ,&nbsp;Benafif Sarah","doi":"10.1016/j.lungcan.2025.108202","DOIUrl":"10.1016/j.lungcan.2025.108202","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108202"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
93 A regional-West Midlands audit on implementing the neo-adjuvant chemoimmunotherapy (NACIO) pathway for resectable non-small cell Cancer (NSCLC) patients
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108203
Chaudhary Prabhav , Budacan Alina , Jegannathen Apurna , Srinivasan Lakshmi , Mahendran Kajan , Ghosh Shilajith , Abah Udo , Sivaramalingam Muthiah , Jesani Hannah , Wotton Robin
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引用次数: 0
17 Multi-region patient feedback on a self-referral CXR services exploring patient behaviours and reasons for accessing the service
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108128
Choon Kon Yune Willy , Start Joanna , Grundy Seamus , Evison Matthew , Armstrong Michael , Brown Louise , Cronin Jane , Smedley Leonie , Dunn Louise , Brickhill Dianne , Taylor Sarah , Bhartia Bobby , Gibson Hayley , Mars Jane , Kennedy Martyn , Bradley Steve , Nasser Rehan
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引用次数: 0
37 Diagnostic performance across two high-volume EBUS services in Greater Manchester with and without Rapid On-Site Evaluation (ROSE)
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108147
Al-Najjar Haider , Almadhi Marwah , Rajai Azita , Narine Nadira , Rana Durgesh , Balata Haval , Evison Matthew
{"title":"37 Diagnostic performance across two high-volume EBUS services in Greater Manchester with and without Rapid On-Site Evaluation (ROSE)","authors":"Al-Najjar Haider ,&nbsp;Almadhi Marwah ,&nbsp;Rajai Azita ,&nbsp;Narine Nadira ,&nbsp;Rana Durgesh ,&nbsp;Balata Haval ,&nbsp;Evison Matthew","doi":"10.1016/j.lungcan.2025.108147","DOIUrl":"10.1016/j.lungcan.2025.108147","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108147"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
89 Why do almost half of our patients not complete 12 months of maintenance durvalumab after successful radical chemoradiotherapy?
IF 4.5 2区 医学 Q1 ONCOLOGY
Lung Cancer
Pub Date : 2025-02-01 DOI: 10.1016/j.lungcan.2025.108199
Zaman Kawish khan , Roberts Dafydd Prys , Edwards Bleddyn , Brewster Alison , Vigneswaran Vallipuram , Lester Jason Farncis
{"title":"89 Why do almost half of our patients not complete 12 months of maintenance durvalumab after successful radical chemoradiotherapy?","authors":"Zaman Kawish khan ,&nbsp;Roberts Dafydd Prys ,&nbsp;Edwards Bleddyn ,&nbsp;Brewster Alison ,&nbsp;Vigneswaran Vallipuram ,&nbsp;Lester Jason Farncis","doi":"10.1016/j.lungcan.2025.108199","DOIUrl":"10.1016/j.lungcan.2025.108199","url":null,"abstract":"","PeriodicalId":18129,"journal":{"name":"Lung Cancer","volume":"200 ","pages":"Article 108199"},"PeriodicalIF":4.5,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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