Shimaa Elgamal, H. Egila, I. Kabbash, Hussien El-Ansarey, Mohamed Elshafie, O. ELShafei
Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta-blockers are widely used to prevent and reduce the frequency of these attacks. However, the use of topical beta-blockers for acute treatment is still controversial. Aims: In this randomized double-armed study, we aim to compare the efficacy of timolol 0.5% eye drops compared with other over-the-counter (OTC) medications used for the acute treatment of migraine. Patients and methods: Fifty-seven patients were randomly allocated to group A (treatment group: timolol 0.5% eye drops) and group B (control group: OTC drugs including NSAIDs, caffeine, aspirin, and acetaminophen). The primary outcome was pain reduction. Secondary outcome measures included reducing nausea, vomiting, photophobia, and phonophobia. Results: Median pain reduction for the OTC group was higher than for timolol (6, 4 prospectively) with a significant U test (P < 0.001). We found a significant correlation between pain severity and degree of pain reduction (r 1⁄4 0.480, P < 0.001). Twenty-six (89.6%) patients in the control group compared with eight (28.6%) patients in the timolol group reported pain reduction by 5 or more. Both timolol and OTC were effective on headache associations: nausea, photophobia, and phonophobia. Conclusion: Both timolol and OTC are equally effective in acute migraine attacks. But OTC drugs are still preferred due to their superior abortion effect.
背景:偏头痛表现为反复发作的头痛，具有不同的特征和相关症状。口服-受体阻滞剂被广泛用于预防和减少这些发作的频率。然而，局部β受体阻滞剂用于急性治疗仍然存在争议。目的:在这项随机的双臂研究中，我们旨在比较0.5%噻莫洛尔滴眼液与其他非处方(OTC)药物用于急性偏头痛治疗的疗效。患者与方法:将57例患者随机分为A组(治疗组:替莫洛尔0.5%滴眼液)和B组(对照组:非甾体抗炎药、咖啡因、阿司匹林、对乙酰氨基酚等非处方药)。主要结果是疼痛减轻。次要结局指标包括减少恶心、呕吐、畏光和恐音。结果:OTC组的中位疼痛减轻程度高于替莫洛尔组(预期值6,4)，U检验显著(P < 0.001)。我们发现疼痛严重程度与疼痛减轻程度之间存在显著相关性(r 1 / 4 0.480, P < 0.001)。对照组26例(89.6%)患者报告疼痛减轻5个或更多，而替莫洛尔组8例(28.6%)患者报告疼痛减轻5个或更多。替马洛尔和OTC对头痛相关:恶心、畏光和恐音均有效。结论:替马洛尔与OTC治疗急性偏头痛疗效相同。但OTC药物因其流产效果较好，仍是首选。
{"title":"Timolol as a migraine acute attack therapy: randomized, OTCs control study","authors":"Shimaa Elgamal, H. Egila, I. Kabbash, Hussien El-Ansarey, Mohamed Elshafie, O. ELShafei","doi":"10.58775/2735-3990.1370","DOIUrl":"https://doi.org/10.58775/2735-3990.1370","url":null,"abstract":"Background: Migraine is manifested by recurrent headache attacks, with variable characteristics and associated symptoms. Oral beta-blockers are widely used to prevent and reduce the frequency of these attacks. However, the use of topical beta-blockers for acute treatment is still controversial. Aims: In this randomized double-armed study, we aim to compare the efficacy of timolol 0.5% eye drops compared with other over-the-counter (OTC) medications used for the acute treatment of migraine. Patients and methods: Fifty-seven patients were randomly allocated to group A (treatment group: timolol 0.5% eye drops) and group B (control group: OTC drugs including NSAIDs, caffeine, aspirin, and acetaminophen). The primary outcome was pain reduction. Secondary outcome measures included reducing nausea, vomiting, photophobia, and phonophobia. Results: Median pain reduction for the OTC group was higher than for timolol (6, 4 prospectively) with a significant U test (P < 0.001). We found a significant correlation between pain severity and degree of pain reduction (r 1⁄4 0.480, P < 0.001). Twenty-six (89.6%) patients in the control group compared with eight (28.6%) patients in the timolol group reported pain reduction by 5 or more. Both timolol and OTC were effective on headache associations: nausea, photophobia, and phonophobia. Conclusion: Both timolol and OTC are equally effective in acute migraine attacks. But OTC drugs are still preferred due to their superior abortion effect.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81282572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara M. Khashaba, Mohammed M Elmogy, H. F. Mohamed, Mohammad El-Nablaway, A. Ismael, MSc Dermatology, St, Abbas ElAkkad
Background : Vitiligo is the most common skin depigmentation disorder. Destruction of melanocytes results in depigmented skin lesions. Pathogenesis is not fully understood and mostly is multifactorial. However, the autoimmune theory is the most widely accepted one. Interaction between genetic, environmental, biochemical, and immunologic factors contribute to the disease. Cytokines have an important role in the development of the disease and its progression. Aim : The aim of the study is to measure the blood levels of C-X-C motif chemokine ligand 10 (CXCL10) in vitiligo and to correlate it with disease activity and severity. Patients and methods : This is a case e control study that enrolled 60 vitiligo patients (30 had active vitiligo and 30 had stable vitiligo) and 30 healthy age-matched and sex-matched controls. Vitiligo extent score (VES) was calculated. CXCL10 was measured in venous blood samples using enzyme-linked immunosorbent assay. Results : CXCL10 levels were signi fi cantly higher among vitiligo patients compared with controls ( P < 0.001). Also, CXCL10 levels in vitiligo patients were signi fi cantly higher in the active group compared with the stable group ( P < 0.001). There was statistically signi fi cant positive correlation between CXCL10 levels and VES score ( P ¼ 0.003). Median CXCL10 (pg/ml) in controls was 2.38 versus 8.13 in patients. Furthermore, in vitiligo patients, the median CXCL10 (pg/ml) was 9.5 in the active group versus 7.6 in the stable group. Conclusions : Serum levels of CXCL10 were signi fi cantly higher in vitiligo patients compared with healthy controls. Furthermore, patients with active vitiligo had higher levels of CXCL10 compared with the stable group. Moreover, patients with higher VES had higher CXCL10 serum levels.
{"title":"Assessment of Serum Levels of CXCL10 in Patients with Non-Segmental Vitiligo","authors":"Sara M. Khashaba, Mohammed M Elmogy, H. F. Mohamed, Mohammad El-Nablaway, A. Ismael, MSc Dermatology, St, Abbas ElAkkad","doi":"10.58775/2735-3990.1369","DOIUrl":"https://doi.org/10.58775/2735-3990.1369","url":null,"abstract":"Background : Vitiligo is the most common skin depigmentation disorder. Destruction of melanocytes results in depigmented skin lesions. Pathogenesis is not fully understood and mostly is multifactorial. However, the autoimmune theory is the most widely accepted one. Interaction between genetic, environmental, biochemical, and immunologic factors contribute to the disease. Cytokines have an important role in the development of the disease and its progression. Aim : The aim of the study is to measure the blood levels of C-X-C motif chemokine ligand 10 (CXCL10) in vitiligo and to correlate it with disease activity and severity. Patients and methods : This is a case e control study that enrolled 60 vitiligo patients (30 had active vitiligo and 30 had stable vitiligo) and 30 healthy age-matched and sex-matched controls. Vitiligo extent score (VES) was calculated. CXCL10 was measured in venous blood samples using enzyme-linked immunosorbent assay. Results : CXCL10 levels were signi fi cantly higher among vitiligo patients compared with controls ( P < 0.001). Also, CXCL10 levels in vitiligo patients were signi fi cantly higher in the active group compared with the stable group ( P < 0.001). There was statistically signi fi cant positive correlation between CXCL10 levels and VES score ( P ¼ 0.003). Median CXCL10 (pg/ml) in controls was 2.38 versus 8.13 in patients. Furthermore, in vitiligo patients, the median CXCL10 (pg/ml) was 9.5 in the active group versus 7.6 in the stable group. Conclusions : Serum levels of CXCL10 were signi fi cantly higher in vitiligo patients compared with healthy controls. Furthermore, patients with active vitiligo had higher levels of CXCL10 compared with the stable group. Moreover, patients with higher VES had higher CXCL10 serum levels.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"347 8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80224001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-28DOI: 10.21608/mvmj.2023.184330.1126
Marwa Genedy, Mai A. M. El‐Son, R. Adawy, V. Zaki
{"title":"Prevalence, virulence genes, and antibiogram profile of Aeromonas hydrophila isolated from diseased Oreochromis niloticus and Clarias gariepinus in Dakahlia province, Egypt","authors":"Marwa Genedy, Mai A. M. El‐Son, R. Adawy, V. Zaki","doi":"10.21608/mvmj.2023.184330.1126","DOIUrl":"https://doi.org/10.21608/mvmj.2023.184330.1126","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85499981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-12DOI: 10.21608/mvmj.2023.186736.1131
E. Risha
{"title":"Naringenin attenuates Hematobiochemical and histopathological alterations induced by lead intoxication in rats","authors":"E. Risha","doi":"10.21608/mvmj.2023.186736.1131","DOIUrl":"https://doi.org/10.21608/mvmj.2023.186736.1131","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88234956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-07DOI: 10.21608/mvmj.2023.190298.1133
Verginia M. Farag, Yasser F. Elnaker, Mohamed Saad, Hydar Abou-Saleh, S. Atwa
{"title":"Comparative immunological changes in cattle vaccinated with sheep pox virus (RM-65) or sheep and goat pox virus (KSGP-0240) vaccines","authors":"Verginia M. Farag, Yasser F. Elnaker, Mohamed Saad, Hydar Abou-Saleh, S. Atwa","doi":"10.21608/mvmj.2023.190298.1133","DOIUrl":"https://doi.org/10.21608/mvmj.2023.190298.1133","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82649424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-06DOI: 10.21608/mvmj.2023.190788.1134
Abdelaziz Rabea, I. Ibrahim, Hebatallah A. Mahgoub, Ahmed Elshaieb
{"title":"Pathological, ultrastructural and hematological studies on single and combined effect of dietary supplementation with lauric and benzoic acids on Nile tilapia","authors":"Abdelaziz Rabea, I. Ibrahim, Hebatallah A. Mahgoub, Ahmed Elshaieb","doi":"10.21608/mvmj.2023.190788.1134","DOIUrl":"https://doi.org/10.21608/mvmj.2023.190788.1134","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78379516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-02-06DOI: 10.21608/mvmj.2023.118019.1100
Mohamed Salah Masoud, M. Badr, H. El-Sheikh Ali
{"title":"The effect of season and ovarian storage time on oocytes recovery and quality in dromedary camel","authors":"Mohamed Salah Masoud, M. Badr, H. El-Sheikh Ali","doi":"10.21608/mvmj.2023.118019.1100","DOIUrl":"https://doi.org/10.21608/mvmj.2023.118019.1100","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87321863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-28DOI: 10.21608/mvmj.2023.185869.1130
Seham Gomma
{"title":"Evaluating the potential use of resveratrol in alleviating biochemical alterations, immune responses, and tissue pathology-associated with subacute malathion toxicity in Nile tilapia.","authors":"Seham Gomma","doi":"10.21608/mvmj.2023.185869.1130","DOIUrl":"https://doi.org/10.21608/mvmj.2023.185869.1130","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"107 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85691783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-22DOI: 10.21608/mvmj.2023.181997.1125
Amal Awad, W. Mohamed, G. Younis
{"title":"Phylotypes, antimicrobial susceptibility phenotypes and virulence determinants of Escherichia coli isolates from broiler chickens infected with colibacillosis","authors":"Amal Awad, W. Mohamed, G. Younis","doi":"10.21608/mvmj.2023.181997.1125","DOIUrl":"https://doi.org/10.21608/mvmj.2023.181997.1125","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82199962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-22DOI: 10.21608/mvmj.2023.164547.1122
Sara Youssef, S. Salem, Rania A. Ahmed, Tarek Ibrahim
{"title":"Effect of protein reduction with indispensable amino acid supplementation at different levels in practical diets of Nile tilapia (Oreochromis niloticus) fish.","authors":"Sara Youssef, S. Salem, Rania A. Ahmed, Tarek Ibrahim","doi":"10.21608/mvmj.2023.164547.1122","DOIUrl":"https://doi.org/10.21608/mvmj.2023.164547.1122","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80974988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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