Alaa Alsawak, O. Abdallah, A. Madian, H. Atalla, Ramadan Eldamarawy, Ahmed Eliwa, A. Khamiss, A. Sharkawy, Sadek Mostafa, A. Alaboudy, M. Maher, Ashraf Elbahrawy
Background/aim: The coronavirus disease 2019 (COVID-19) pandemic has a major impact on the clinical course of chronic diseases including inflammatory bowel disease (IBD). In the current study, we aimed to evaluate the clinical relapse and worsening of IBD activity during the COVID-19 pandemic. Patients and methods: In this study 125 patients were included and were followed up for 1 year. Of them, 98 and 27 patients had inactive and active IBD before the study, respectively. The clinical activity of IBD was assessed by Crohn's disease activity index and simplified colitis clinical activity index. Severe acute respiratory distress syndrome coronavirus 2 infection was detected by real-time PCR. Results: The mean age of included patients was 34.3 ± 11.2 years, of them 54 (43.2%) were males. Forty three (34.4%) and 82(65.6%) patients had Crohn's disease and ulcerative colitis, respectively. Forty-six (47%) patients developed a clinical relapse within 1 year. Of them, 22 (48%) patients were not adherent to treatment during the pandemic (P ≤ 0.05); 33.3% of patients with active IBD before the study had worsened activity during the pandemic. The incidence of severe acute respiratory distress syndrome coronavirus 2 infection among the included patients was 8% (n 1⁄4 10). Conclusion: The majority of relapsed IBD patients were not adherent to treatment due to the fear of COVID-19 infection.
{"title":"Impact of COVID - 19 Pandemic on The Clinical Course of Inflammatory Bowel Disease in Egyptian Tertiary Centers","authors":"Alaa Alsawak, O. Abdallah, A. Madian, H. Atalla, Ramadan Eldamarawy, Ahmed Eliwa, A. Khamiss, A. Sharkawy, Sadek Mostafa, A. Alaboudy, M. Maher, Ashraf Elbahrawy","doi":"10.58775/2735-3990.1371","DOIUrl":"https://doi.org/10.58775/2735-3990.1371","url":null,"abstract":"Background/aim: The coronavirus disease 2019 (COVID-19) pandemic has a major impact on the clinical course of chronic diseases including inflammatory bowel disease (IBD). In the current study, we aimed to evaluate the clinical relapse and worsening of IBD activity during the COVID-19 pandemic. Patients and methods: In this study 125 patients were included and were followed up for 1 year. Of them, 98 and 27 patients had inactive and active IBD before the study, respectively. The clinical activity of IBD was assessed by Crohn's disease activity index and simplified colitis clinical activity index. Severe acute respiratory distress syndrome coronavirus 2 infection was detected by real-time PCR. Results: The mean age of included patients was 34.3 ± 11.2 years, of them 54 (43.2%) were males. Forty three (34.4%) and 82(65.6%) patients had Crohn's disease and ulcerative colitis, respectively. Forty-six (47%) patients developed a clinical relapse within 1 year. Of them, 22 (48%) patients were not adherent to treatment during the pandemic (P ≤ 0.05); 33.3% of patients with active IBD before the study had worsened activity during the pandemic. The incidence of severe acute respiratory distress syndrome coronavirus 2 infection among the included patients was 8% (n 1⁄4 10). Conclusion: The majority of relapsed IBD patients were not adherent to treatment due to the fear of COVID-19 infection.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88669498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Zedan, Mai Magdy Kera, E. Khashaba, Mona El wassefy, A. Osman
Background: Asthma is a heterogenous disease with variable characteristic phenotypes. Correlating clinical asthma phenotypes with the underlying genotypes could pave the way for the development of tailored asthma medications. Objective: The purpose of this study was to describe the clinical features of wheezy and cough asthma phenotypes and to assess the frequency of CCR3 T51C gene polymorphism among Egyptian asthmatic children. Methods: A group of 60 Egyptian asthmatic children (40 wheezy phenotypes and 20 cough phenotypes) together with 100 controls were enrolled and analyzed for the genotypes of CCR3 T51C polymorphisms using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Serum IgE levels were determined by the ELISA technique. Results: Regarding clinical characteristics, associated allergic rhinitis and atopic dermatitis were found to be significantly higher among the wheezy phenotype compared with the cough phenotype. Also, most of the patients with the wheezy phenotype had moderate to severe asthma, while most of the patients with the cough phenotype had mild asthma. Regarding the frequency of CCR3 T51C genotypes, the TT homozygote genotype was the most frequent genotype among cases and controls. However, no statistically significant differences were found between the two clinical phenotypes. Conclusion: In our studied population, the wheezy asthma phenotype was characterized by a higher frequency of associated allergic march and increased asthma severity. Yet, our results deny the value of CCR3 T51C genetic polymorphism as a genetic marker for differentiating between wheezy and cough asthma phenotypes.
{"title":"Wheezy and Cough Asthma Phenotypes in a cohort of Egyptian Children: Clinical features and CCR3 T51C Gene Polymorphism","authors":"M. Zedan, Mai Magdy Kera, E. Khashaba, Mona El wassefy, A. Osman","doi":"10.58775/2735-3990.1379","DOIUrl":"https://doi.org/10.58775/2735-3990.1379","url":null,"abstract":"Background: Asthma is a heterogenous disease with variable characteristic phenotypes. Correlating clinical asthma phenotypes with the underlying genotypes could pave the way for the development of tailored asthma medications. Objective: The purpose of this study was to describe the clinical features of wheezy and cough asthma phenotypes and to assess the frequency of CCR3 T51C gene polymorphism among Egyptian asthmatic children. Methods: A group of 60 Egyptian asthmatic children (40 wheezy phenotypes and 20 cough phenotypes) together with 100 controls were enrolled and analyzed for the genotypes of CCR3 T51C polymorphisms using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Serum IgE levels were determined by the ELISA technique. Results: Regarding clinical characteristics, associated allergic rhinitis and atopic dermatitis were found to be significantly higher among the wheezy phenotype compared with the cough phenotype. Also, most of the patients with the wheezy phenotype had moderate to severe asthma, while most of the patients with the cough phenotype had mild asthma. Regarding the frequency of CCR3 T51C genotypes, the TT homozygote genotype was the most frequent genotype among cases and controls. However, no statistically significant differences were found between the two clinical phenotypes. Conclusion: In our studied population, the wheezy asthma phenotype was characterized by a higher frequency of associated allergic march and increased asthma severity. Yet, our results deny the value of CCR3 T51C genetic polymorphism as a genetic marker for differentiating between wheezy and cough asthma phenotypes.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85234867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. El-Ghaffar, Amal AF Halim, E. Abdallah, Doaa A Sharaf, S. Yussif
Objective : Breast cancer (BC) tissue is heterogeneous with a number of cellular pathways involved in cell growth and proliferation. Activation of androgen receptors (AR) signaling pathways plays a role in BC. On the other hand, cyclin is a regulatory subunit of cyclin-dependent kinases that affect cell cycle G1/S transition. This study aimed at investigating the relationship between the expression of AR and cyclin D1 and the clinicopathological details of BC patients registered in the archive of our department within a speci fi ed period and determining the prognostic impact of such expression. Methods : The study included 182 IDC patients aged from 20 to 65 whom were registered in the archive of the Clinical Oncology & Nuclear Medicine Department from January 2013 to December 2015. All clinicopathological data were obtained from patient records. Immunohistochemistry study for AR and cyclin D1 was done for the pathologic specimens. Results : The expression ratio of AR in 182 specimens was 43.4% (79/182). AR positivity was signi fi cantly associated with estrogen receptor (ER) and progesterone receptor (PR) positivity and negative HER2 status, lower tumor grade, smaller tumor size, and negative lymph node involvement ( P values < 0.05). Cyclin D1 positivity was reported in 116/182 (64%). There was positive correlation between cyclin D1 and ER, PR positivity, triple negativity, small tumor size, and negative lymph node involvement ( P value < 0.05). The
{"title":"The prognostic value of androgen receptor and cyclin D1 in infiltrating duct carcinoma of the breast","authors":"D. El-Ghaffar, Amal AF Halim, E. Abdallah, Doaa A Sharaf, S. Yussif","doi":"10.58775/2735-3990.1387","DOIUrl":"https://doi.org/10.58775/2735-3990.1387","url":null,"abstract":"Objective : Breast cancer (BC) tissue is heterogeneous with a number of cellular pathways involved in cell growth and proliferation. Activation of androgen receptors (AR) signaling pathways plays a role in BC. On the other hand, cyclin is a regulatory subunit of cyclin-dependent kinases that affect cell cycle G1/S transition. This study aimed at investigating the relationship between the expression of AR and cyclin D1 and the clinicopathological details of BC patients registered in the archive of our department within a speci fi ed period and determining the prognostic impact of such expression. Methods : The study included 182 IDC patients aged from 20 to 65 whom were registered in the archive of the Clinical Oncology & Nuclear Medicine Department from January 2013 to December 2015. All clinicopathological data were obtained from patient records. Immunohistochemistry study for AR and cyclin D1 was done for the pathologic specimens. Results : The expression ratio of AR in 182 specimens was 43.4% (79/182). AR positivity was signi fi cantly associated with estrogen receptor (ER) and progesterone receptor (PR) positivity and negative HER2 status, lower tumor grade, smaller tumor size, and negative lymph node involvement ( P values < 0.05). Cyclin D1 positivity was reported in 116/182 (64%). There was positive correlation between cyclin D1 and ER, PR positivity, triple negativity, small tumor size, and negative lymph node involvement ( P value < 0.05). The","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78441639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maram Mohamed Rashad Ghoniem, A. Elsharabasy, Y. Shabana, E. Ismail
Background: The purpose of this study was to investigate changes in electrical evoked stapedial reflex thresholds (ESRTs) and electrodes impedance over time in children with MED-EL cochlear implants. Methods: In this study, 60 kids were included, while 15 kids were excluded because their cases did not fit the requirements. Patients who received MED-EL cochlear implants were monitored postoperatively over 5 years to determine whether or not their electrical evoked stapedial reflex thresholds (ESRT) and electrode impedance remained stable. Results: At the initial fitting, electrodes 4, 5, 6, 8, and 9 showed significantly different impedances, while electrodes 1, 2, 3, 7, 10, 11, and 12 showed no significantly different impedances. Excluding electrode 12, all electrodes showed a statistically significant difference in ESRT at three and 6 months. All electrodes, except electrodes 7 and 8, showed no difference between ESRT and the behaviorally based MAP most comfortable level (MCL). After three months, there was a highly significant difference between ESRT and the behavioral MAP for the audiometric frequencies 500, 1000, 2000, and 4000 Hz. Conclusion: Particularly at 3 and 6 months, there was a considerable decrease in electrode impedance, which stabilized throughout the course of the remaining follow-up period. Nearly all the electrodes showed a significant variation in ESRT between 3 and 6 months, but over the subsequent 5 years, ESRT essentially stabilized. Additionally, there was no difference between behavioral-based MAP and ESRT MCL; nevertheless, after 3 months, there was a highly significant difference between ESRT and the behavioral MAP at the 500, 1000, 2000, and 4000 Hz audiometric frequencies.
{"title":"Long-term stability of electrical stapedial reflex and electrodes impedance in children with MED-EL cochlear implants","authors":"Maram Mohamed Rashad Ghoniem, A. Elsharabasy, Y. Shabana, E. Ismail","doi":"10.58775/2735-3990.1381","DOIUrl":"https://doi.org/10.58775/2735-3990.1381","url":null,"abstract":"Background: The purpose of this study was to investigate changes in electrical evoked stapedial reflex thresholds (ESRTs) and electrodes impedance over time in children with MED-EL cochlear implants. Methods: In this study, 60 kids were included, while 15 kids were excluded because their cases did not fit the requirements. Patients who received MED-EL cochlear implants were monitored postoperatively over 5 years to determine whether or not their electrical evoked stapedial reflex thresholds (ESRT) and electrode impedance remained stable. Results: At the initial fitting, electrodes 4, 5, 6, 8, and 9 showed significantly different impedances, while electrodes 1, 2, 3, 7, 10, 11, and 12 showed no significantly different impedances. Excluding electrode 12, all electrodes showed a statistically significant difference in ESRT at three and 6 months. All electrodes, except electrodes 7 and 8, showed no difference between ESRT and the behaviorally based MAP most comfortable level (MCL). After three months, there was a highly significant difference between ESRT and the behavioral MAP for the audiometric frequencies 500, 1000, 2000, and 4000 Hz. Conclusion: Particularly at 3 and 6 months, there was a considerable decrease in electrode impedance, which stabilized throughout the course of the remaining follow-up period. Nearly all the electrodes showed a significant variation in ESRT between 3 and 6 months, but over the subsequent 5 years, ESRT essentially stabilized. Additionally, there was no difference between behavioral-based MAP and ESRT MCL; nevertheless, after 3 months, there was a highly significant difference between ESRT and the behavioral MAP at the 500, 1000, 2000, and 4000 Hz audiometric frequencies.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73487808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kartagener ' s syndrome (KS) is a rare inherited autosomal recessive condition. It comprises the triad chronic sinusitis, bronchiectasis, and situs inversus. The symptoms are more prevalent in children in the early years of life. We describe a case of a 15-year-old child showing severe respiratory distress with a history of intermittent wet cough and rhinitis for the past 6 months. The patient was diagnosed with dextrocardia at birth and had no signi fi cant medical history since then. Based on his clinical presentation and imaging fi ndings, he was diagnosed with KS which was con fi rmed by whole-exome sequencing. The patient was managed with conventional medical therapy and noninvasive ventilation. He was discharged on a long-term intermittent prophylactic antibiotic regimen. KS should be suspected in any child with dextrocardia who has recurrent respiratory tract infections. Early detection of KS is critical for avoiding complications and improving patients ' quality of life.
{"title":"Unusual Late Presentation of Kartagener Syndrome: A Case Report","authors":"A. H. Al-Mazroea","doi":"10.58775/2735-3990.1389","DOIUrl":"https://doi.org/10.58775/2735-3990.1389","url":null,"abstract":"Kartagener ' s syndrome (KS) is a rare inherited autosomal recessive condition. It comprises the triad chronic sinusitis, bronchiectasis, and situs inversus. The symptoms are more prevalent in children in the early years of life. We describe a case of a 15-year-old child showing severe respiratory distress with a history of intermittent wet cough and rhinitis for the past 6 months. The patient was diagnosed with dextrocardia at birth and had no signi fi cant medical history since then. Based on his clinical presentation and imaging fi ndings, he was diagnosed with KS which was con fi rmed by whole-exome sequencing. The patient was managed with conventional medical therapy and noninvasive ventilation. He was discharged on a long-term intermittent prophylactic antibiotic regimen. KS should be suspected in any child with dextrocardia who has recurrent respiratory tract infections. Early detection of KS is critical for avoiding complications and improving patients ' quality of life.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87479103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sobh, Noha Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, M. H. Elnagdy, A. E. Abdulgalil
{"title":"Outcome of COVID-19 in patients with rheumatic diseases treated with immunosuppressive drugs","authors":"A. Sobh, Noha Elnagdy, Mohamed Elegezy, Mohamed Mofreh, Mohamed Tohlob, Ahmad M. Eita, Ragheed Rizk, Ola Eliwa, M. H. Elnagdy, A. E. Abdulgalil","doi":"10.58775/2735-3990.1391","DOIUrl":"https://doi.org/10.58775/2735-3990.1391","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83383663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. M. ALseoudy, Maha O. Hammad, Mohmed Elgamal, D. Abdelghany, A. Borg, Ahmed El-Mesery, Dina Elzeiny
Background : Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions in the regulation of immunity are mediated by vitamin D receptors (VDRs). Polymorphisms in the VDR gene have been associated with several health outcomes; however, their effects on COVID-19 still need more clari fi cation. This study aims to investigate the association of the VDR SNP (rs11568820, Cdx-2) with susceptibility and interindividual variability of the severity of COVID-19. Methods : A total of 100 con fi rmed COVID-19 patients and 100 age and sex-matched controls were enrolled in this study between July and September 2021. COVID-19 patients were further subdivided into severe ( n ¼ 50) and nonsevere ( n ¼ 50) cases. All participants were subjected to genotyping of Cdx-2 SNP using the allelic discrimination of the Real-time PCR technique and assay of serum 25(OH)D levels by ELISA. Results : The results showed that the homozygous “ GG ” genotype was signi fi cantly higher in patients vs. controls, whereas the heterozygous “ AG ” genotype was signi fi cantly lower in COVID-19 patients. Thus, the heterozygous “ AG ” genotype is considered the protective genotype. This protection was more signi fi cant among males vs. females ( P ¼ 0.02). However, there were no statistically signi fi cant differences in the genotype distributions of VDR Cdx-2 SNP between severe and nonsevere patients. Moreover, COVID-19 patients with the “ AG ” genotype presented higher 25(OH)D levels than the “ GG ” genotype ( P ¼ 0.02). Conclusions : VDR SNP (rs11568820, Cdx-2) might be a potential risk factor for COVID-19, particularly among male patients.
背景:宿主遗传变异被认为是COVID-19易感性和严重程度的个体间差异的重要解释。大多数维生素D在免疫调节中的作用是由维生素D受体(vdr)介导的。VDR基因的多态性与几种健康结果有关;然而，它们对COVID-19的影响仍需要进一步阐明。本研究旨在探讨VDR SNP (rs11568820, Cdx-2)与COVID-19易感性和严重程度的个体间差异的关系。方法:在2021年7月至9月期间，共招募了100名确诊的COVID-19患者和100名年龄和性别匹配的对照组。COVID-19患者进一步细分为重症(n¼50)和非重症(n¼50)病例。所有受试者均采用Real-time PCR等位基因鉴别技术进行Cdx-2 SNP基因分型，ELISA检测血清25(OH)D水平。结果:结果显示，纯合子“GG”基因型在患者中显著高于对照组，而杂合子“AG”基因型在COVID-19患者中显著低于对照组。因此，杂合子“AG”基因型被认为是保护性基因型。这种保护作用在男性和女性之间更为显著(P < 0.05)。但VDR Cdx-2 SNP基因型分布在重症与非重症患者间无统计学差异。AG基因型患者25(OH)D水平高于GG基因型患者(P < 0.05)。结论:VDR SNP (rs11568820, Cdx-2)可能是COVID-19的潜在危险因素，尤其是在男性患者中。
{"title":"Association of vitamin D receptor Cdx-2 polymorphism with COVID-19: A case-control study","authors":"M. M. ALseoudy, Maha O. Hammad, Mohmed Elgamal, D. Abdelghany, A. Borg, Ahmed El-Mesery, Dina Elzeiny","doi":"10.58775/2735-3990.1382","DOIUrl":"https://doi.org/10.58775/2735-3990.1382","url":null,"abstract":"Background : Host genetic variability has been suggested as an important explanation for inter-individual differences in COVID-19 susceptibility and severity. Most vitamin D actions in the regulation of immunity are mediated by vitamin D receptors (VDRs). Polymorphisms in the VDR gene have been associated with several health outcomes; however, their effects on COVID-19 still need more clari fi cation. This study aims to investigate the association of the VDR SNP (rs11568820, Cdx-2) with susceptibility and interindividual variability of the severity of COVID-19. Methods : A total of 100 con fi rmed COVID-19 patients and 100 age and sex-matched controls were enrolled in this study between July and September 2021. COVID-19 patients were further subdivided into severe ( n ¼ 50) and nonsevere ( n ¼ 50) cases. All participants were subjected to genotyping of Cdx-2 SNP using the allelic discrimination of the Real-time PCR technique and assay of serum 25(OH)D levels by ELISA. Results : The results showed that the homozygous “ GG ” genotype was signi fi cantly higher in patients vs. controls, whereas the heterozygous “ AG ” genotype was signi fi cantly lower in COVID-19 patients. Thus, the heterozygous “ AG ” genotype is considered the protective genotype. This protection was more signi fi cant among males vs. females ( P ¼ 0.02). However, there were no statistically signi fi cant differences in the genotype distributions of VDR Cdx-2 SNP between severe and nonsevere patients. Moreover, COVID-19 patients with the “ AG ” genotype presented higher 25(OH)D levels than the “ GG ” genotype ( P ¼ 0.02). Conclusions : VDR SNP (rs11568820, Cdx-2) might be a potential risk factor for COVID-19, particularly among male patients.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89652659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-14DOI: 10.21608/mjmu.2022.151954.1131
N. Elsaid, Ahmed A H Mosa, A. Saied
Background : Obstructive sleep apnea (OSA) is one of the risk factors for idiopathic intracranial hypertension (IIH). The Berlin questionnaire (BQ) is a validated reliable method for the identi fi cation of an increased likelihood of OSA. We aimed to screen a sample of female IIH patients for OSA using the BQ. Patients and methods : This study included 40 females; 20 newly diagnosed IIH patients and 20 healthy controls. The BQ was obtained from all of the study participants, and it was divided into high or low risk for OSA. Results : The patient and control cohorts were age-matched. The BMI was signi fi cantly higher in the IIH group (median 36, range 24 e 42) than in the control group (median 28, range 20 e 41) ( P ¼ 0.005). Of the IIH patient group, 45% had a high-risk BQ score, while only 15% of the healthy control group had a high-risk score ( P ¼ 0.038). Conclusion : Stratifying the risk of OSA in IIH may be feasible using the BQ. A high likelihood for OSA in BQ is more common in patients of IIH. Polysomnography may be warranted in IIH patients with high-risk BQ scores to reduce the morbidities associated with OSA, especially in obese patients.
{"title":"Screening for obstructive sleep apnea in a sample of Egyptian idiopathic intracranial hypertension female patients using the Berlin questionnaire","authors":"N. Elsaid, Ahmed A H Mosa, A. Saied","doi":"10.21608/mjmu.2022.151954.1131","DOIUrl":"https://doi.org/10.21608/mjmu.2022.151954.1131","url":null,"abstract":"Background : Obstructive sleep apnea (OSA) is one of the risk factors for idiopathic intracranial hypertension (IIH). The Berlin questionnaire (BQ) is a validated reliable method for the identi fi cation of an increased likelihood of OSA. We aimed to screen a sample of female IIH patients for OSA using the BQ. Patients and methods : This study included 40 females; 20 newly diagnosed IIH patients and 20 healthy controls. The BQ was obtained from all of the study participants, and it was divided into high or low risk for OSA. Results : The patient and control cohorts were age-matched. The BMI was signi fi cantly higher in the IIH group (median 36, range 24 e 42) than in the control group (median 28, range 20 e 41) ( P ¼ 0.005). Of the IIH patient group, 45% had a high-risk BQ score, while only 15% of the healthy control group had a high-risk score ( P ¼ 0.038). Conclusion : Stratifying the risk of OSA in IIH may be feasible using the BQ. A high likelihood for OSA in BQ is more common in patients of IIH. Polysomnography may be warranted in IIH patients with high-risk BQ scores to reduce the morbidities associated with OSA, especially in obese patients.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74098664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-13DOI: 10.21608/mjmu.2022.178838.1151
A. Mowafy
{"title":"Efficacy of Epidural and Intramuscular Bupivacaine Injection for Patients Undergoing Lumbar Spine Discectomy on Post-operative Pain Assessment by Visual Analogue Score (VAS)","authors":"A. Mowafy","doi":"10.21608/mjmu.2022.178838.1151","DOIUrl":"https://doi.org/10.21608/mjmu.2022.178838.1151","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81028357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-13DOI: 10.21608/mjmu.2022.176871.1150
Asmaa Ibrahim
{"title":"Clinical and biochemical parameters in obese women with polycystic ovary syndrome","authors":"Asmaa Ibrahim","doi":"10.21608/mjmu.2022.176871.1150","DOIUrl":"https://doi.org/10.21608/mjmu.2022.176871.1150","url":null,"abstract":"","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72750428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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