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protective and therapeutic effect of omega_3 against nephrotoxicity omega - 3对肾毒性的保护和治疗作用
Pub Date : 2023-01-22 DOI: 10.21608/mvmj.2023.185092.1128
Zahra Farid
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引用次数: 0
An overview of meat composition, postmortem changes, and sources of microbial contamination in developing countries abattoirs 发展中国家屠宰场肉类成分、死后变化和微生物污染来源综述
Pub Date : 2023-01-10 DOI: 10.21608/mvmj.2023.185164.1129
H. Elshebrawy, Nahed Kasem, Khalid Sallam
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引用次数: 0
One Stage Procedure versus Two Stages Procedure in Management of Obstructed Non-Perforated Cancer Colon 一期手术与两期手术治疗梗阻性非穿孔结肠癌
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1384
Magdy Basheer, Mahmoud NeamatAllah, A. Abbas, M. Shetiwy
Background: The surgical management of large bowel emergency patients remains controversial. However, there has been an increasing trend toward primary reconstructive surgery. Objective: To evaluate one-stage procedure versus two-stage procedure in cases presented with obstructed nonperforated cancer colon in terms of operative time, hospital stay, postoperative complications, peri-operative mortality, and quality of life. Patients and methods: A prospective randomized study was conducted at Emergency Mansoura University Hospitals. A total of 50 cases diagnosed with obstructed nonperforated cancer colon were randomly allocated into two groups; the first group included 25 cases who underwent the one-stage approach, and the second one included the remaining 25 cases who underwent the two-stage approach. Results: Although the two-staged approach showed an increase in operative time compared to the single-stage approach (174.88 vs. 163.84 min, respectively), that difference was statistically insignificant (P 1⁄4 0.102). Hospital stay showed significant prolongation in the single-stage group (5.8 vs. 3.88 days in the two-stage group e P < 0.001). No significant difference was detected between the study groups regarding postoperative complications. Mortality was encountered only in one case in the one-stage group (4%) due to pulmonary embolism. The prevalence of patient dissatisfaction was significantly higher in the two-stage group (48%) compared to the single-stage group (12%). Conclusion: We concluded no significant increase in perioperative morbidity or mortality rates in the one-stage procedure compared to the staged one when applied for obstructed cancer colon patients.
背景:肠急症患者的手术治疗仍有争议。然而,有越来越多的倾向于原发性重建手术。目的:在手术时间、住院时间、术后并发症、围手术期死亡率和生活质量方面,评估梗阻性非穿孔结肠癌患者一期手术与二期手术的差异。患者和方法:在曼苏拉大学急诊医院进行了一项前瞻性随机研究。50例诊断为梗阻性非穿孔结肠癌的患者随机分为两组;第一组25例采用一期入路,第二组25例采用两期入路。结果:虽然两阶段入路手术时间较单阶段入路增加(分别为174.88 min和163.84 min),但差异无统计学意义(P < 1 / 4 0.102)。单阶段组住院时间明显延长(5.8天vs. 3.88天,两阶段组P < 0.001)。在术后并发症方面,研究组之间没有发现显著差异。在一期组中只有一例(4%)因肺栓塞而死亡。患者不满意的发生率在两阶段组(48%)明显高于单阶段组(12%)。结论:与一期手术相比,一期手术治疗梗阻性结肠癌患者围手术期的发病率和死亡率没有显著增加。
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引用次数: 0
Assessment of hypothyroidism among adult patients suffering from beta thalassemia major 重度β -地中海贫血成年患者甲状腺功能减退的评估
Pub Date : 2023-01-01 DOI: 10.21608/mjmu.2023.167025.1144
A. S. Ibrahim, A. A. E. Abd El Fatah, Ayman Abdel El Haliem, Fared F. Mohamed
Background: Although patients with beta-thalassemia major (BTM) are properly treated with blood transfusions accompanied with iron chelation therapy, they experience serious complications such as hypothyroidism. Aim: This work aims to assess hypothyroidism among adult patients with BTM and to find out its association with various parameters such as age, BMI, sex, hemoglobin, and serum ferritin levels. Patients and methods: This cross-sectional study included 200 adult patients with BTM (males 115 and females 85; mean age 24.684 ± 5.30761 years; range, 18e43 years old). Statistical data analysis was performed using IBM SPSS software package, version 26.0. Results: The overall frequency of hypothyroidism was 9.5%. The maximum frequency was 3.5% within the age group 27eless than 32 years, with serum ferritin level in the range of 2501e3500 ng/ml. Six (3%) of the patients had overt hypothyroidism, and 13 (6.5%) patients had subclinical hypothyroidism; normal values of thyroid hormone were found in 181 (90.5%) patients. No central hypothyroidism was found. Conclusion: The most common subclass of thyroid dysfunction was subclinical hypothyroidism, which was more prevalent than overt hypothyroidism. Early assessment of hypothyroidism should be followed among adult patients with BTM, especially in the age group 27eless than 32 years.
背景:虽然β -地中海贫血(BTM)患者通过输血和铁螯合治疗得到了适当的治疗,但他们会出现严重的并发症,如甲状腺功能减退。目的:本研究旨在评估成年BTM患者的甲状腺功能减退,并发现其与年龄、BMI、性别、血红蛋白和血清铁蛋白水平等各种参数的关系。患者和方法:本横断面研究纳入200例成年BTM患者(男115例,女85例;平均年龄24.684±5.30761岁;年龄:18 - 43岁。采用IBM SPSS 26.0版软件包进行统计数据分析。结果:甲减总发生率为9.5%。27岁以下年龄组发生率最高,为3.5%,血清铁蛋白水平在2501e3500ng /ml之间。6例(3%)有明显的甲状腺功能减退,13例(6.5%)有亚临床甲状腺功能减退;181例(90.5%)患者甲状腺激素正常。未见中枢性甲状腺功能减退。结论:甲状腺功能障碍最常见的亚类是亚临床甲状腺功能减退,其发生率高于显性甲状腺功能减退。成年BTM患者应进行甲状腺功能减退的早期评估,特别是27岁以下32岁的患者。
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引用次数: 0
The Effect Of Hepatitis C Virus Infection On Ovarian Reserve 丙型肝炎病毒感染对卵巢储备的影响
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1388
Khaled Mahmoud Ahmed Amin Abdo, M. Abdelrazik, Eman Salah Eldin Mohamed Fadel, Ashraf A. Foda, Mohamed Abdellatif Elnegeri
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引用次数: 0
Spinal cord lipomas in children: surgical resection and outcome 儿童脊髓脂肪瘤:手术切除及预后
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1375
Ramy Omar Omar El Sakhry, Hatem Badr, Ibrahim A. Abdel-Aal, A. Khalil
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引用次数: 0
Potential Neuroprotective Effect of Artemisinin in a Rotenone-induced Mice Model of Parkinson’s Disease 青蒿素对鱼藤酮诱导的帕金森病小鼠模型的潜在神经保护作用
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1374
Nada M. Hamada, H. Eissa, Nirmeen Megahed, M. Daba, A. Elmasry
Background : Parkinson ' s disease (PD) is characterized by motor dysfunctions, including tremors, rigidity, and brady-kinesia. Medications for PD alleviate motor symptoms rather than targeting disease pathogenesis. Recently discovered features of artemisinin suggested that it might be used to treat neurodegenerative diseases. Objective : To explore the possible neuroprotective effect of artemisinin in different doses in a rotenone-induced model of PD. Materials and methods : A total of 25 mice were randomly divided into fi ve groups: group 1, negative control; group 2, positive control; and groups 3, 4, and 5, artemisinin treated (30, 40, and 50 mg/kg, respectively). For PD induction, rotenone (3 mg/kg/day) was administered intraperitoneally for 42 days (6 weeks). Behavioral assessment (open fi eld and parallel rod tests) was performed twice: after 3 weeks of induction and at the end of the study (after 6 weeks). After scari fi cation, an immunohistochemical analysis of tyrosine hydroxylase in the substantia nigra pars compacta was conducted. Results : Artemisinin administration at a dose of 50 mg/kg produced more pronounced signi fi cant protective effects compared with other diseased and treated groups as guided by behavioral assessment tests and immunostaining analysis. Conclusions : Artemisinin showed a promising protective effect in the rotenone-induced PD model. Further research studies are needed to validate this effect.
背景:帕金森病(PD)以运动功能障碍为特征,包括震颤、僵硬和运动迟缓。PD药物治疗减轻运动症状,而不是针对疾病的发病机制。最近发现的青蒿素的特征表明,它可能用于治疗神经退行性疾病。目的:探讨不同剂量青蒿素对鱼藤酮诱导的帕金森病模型可能的神经保护作用。材料与方法:将25只小鼠随机分为5组:1组为阴性对照;第二组,阳性对照;第3组、第4组和第5组采用青蒿素处理(分别为30、40和50 mg/kg)。对于PD诱导,鱼藤酮(3mg /kg/天)腹腔注射42天(6周)。行为评估(开放场和平行杆测试)进行两次:诱导3周后和研究结束时(6周后)。瘢痕化后,对黑质致密部酪氨酸羟化酶进行免疫组化分析。结果:在行为评估试验和免疫染色分析的指导下,与其他病变组和治疗组相比,50 mg/kg剂量的青蒿素具有更显著的保护作用。结论:青蒿素对鱼藤酮诱导的PD模型具有良好的保护作用。需要进一步的研究来验证这一效应。
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引用次数: 0
Evaluation of CXCL2 and autophagy genes expression in rheumatoid arthritis patients and its relation to cardiovascular diseases 类风湿关节炎患者CXCL2和自噬基因表达的评价及其与心血管疾病的关系
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1373
Mona Elhelaly, D. Nassar, M. Nassar, Khaled AbdElAlim, S. Tharwat
Background: Cardiovascular disease is among the most common comorbidity and the leading cause of mortality in patients with rheumatoid arthritis (RA). The aim of this study was to assess the levels of CXCL2 and autophagy genes such light chain (LC3) and beclin1 in patients with RA and how they relate to the clinical manifestations and carotid intimalemedial thickness. Patients and methods: This cross-sectional study included patients with RA. Sociodemographic characteristics and clinical and therapeutic data were recorded. Thorough medical and clinical examination was conducted to evaluate the disease status, including the number of swollen and tender joints, visual analog scale, and disease activity score 28. Approximately 5 ml of whole blood was collected from each participant, and CXCL2, LC3, and beclin1 expression levels were evaluated. The carotid intimaemedia thickness (CIMT) was assessed by a duplex ultrasound system. As a control group, 79 healthy individuals of matching age and sex were included. Results: A total of 79 patients with RA were included in the study, with mean ± SD age of 45.24 ± 10.07 years. Most of them were females (87.3%), and the median duration of RA was 7 years. Approximately 85% had positive rheumatoid factor, whereas 70.9% had positive anti-CCP antibody. CXCL2 and LC3 had a statistically significant positive correlation of medium strength (P 1⁄4 0.026). CXCL2 showed a significant positive correlation with presence of subcutaneous rheumatoid nodules, whereas there was a positive correlation of low strength between CXCL2 and systolic blood pressure, diastolic blood pressure, and health assessment questionnaire score. For LC3 gene expression, it was significantly correlated positively with presence of joint deformities and negatively with hypercholesterolemia. There was a statistically significant positive correlation of medium strength between LC3 and CIMT in those with disease duration more than or equal to 7 years after controlling (adjusting) for patient's age. Conclusions: CXCL2 and autophagy gene expression levels (LC3 and beclin1) are positively correlated with the clinical manifestations and CIMT in patients with RA. These genes may serve as predictors for cardiovascular disease in patients with RA.
背景:心血管疾病是类风湿性关节炎(RA)患者最常见的合并症之一,也是导致患者死亡的主要原因。本研究的目的是评估RA患者CXCL2和自噬基因如轻链(LC3)和beclin1的水平及其与临床表现和颈动脉内膜厚度的关系。患者和方法:本横断面研究包括RA患者。记录社会人口学特征及临床和治疗数据。通过全面的医学和临床检查来评估疾病状况,包括肿胀和压痛关节的数量,视觉模拟量表,疾病活动评分28。每位参与者采集约5ml全血,评估CXCL2、LC3和beclin1的表达水平。双超声系统评估颈动脉内膜中膜厚度(CIMT)。选取年龄、性别相匹配的健康个体79例作为对照组。结果:共纳入79例RA患者,平均±SD年龄45.24±10.07岁。其中以女性居多(87.3%),RA中位病程为7年。类风湿因子阳性约85%,抗ccp抗体阳性约70.9%。CXCL2与LC3中强度呈正相关(P < 1 / 4 0.026)。CXCL2与皮下类风湿结节存在显著正相关,而CXCL2低强度与收缩压、舒张压、健康评估问卷评分呈正相关。LC3基因表达与关节畸形呈显著正相关,与高胆固醇血症呈显著负相关。在控制(调整)患者年龄后,病程大于等于7年的患者中强度LC3与CIMT呈正相关,有统计学意义。结论:CXCL2及自噬基因表达水平(LC3、beclin1)与RA患者临床表现及CIMT呈正相关。这些基因可能作为类风湿关节炎患者心血管疾病的预测因子。
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引用次数: 0
Total Serum Immunoglobulin E in patients with psoriasis vulgaris 寻常型银屑病患者血清总免疫球蛋白E的变化
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1390
Sara A. Gooda
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引用次数: 0
Value of QRS fragmentation as novel electrocardiogram predictor of reperfusion in acute myocardial infarction patient QRS碎片化作为急性心肌梗死患者再灌注新的心电图预测指标的价值
Pub Date : 2023-01-01 DOI: 10.58775/2735-3990.1380
Hoda M. Sobh, N. Awad, Mohamed Adel Omar
Background: The main target of treatment of ST elevation myocardial infarction (STEMI) is to restore coronary blood flow and maintain myocardial perfusion. Several tools including electrocardiographic and coronary angiographic parameters are used to assess myocardial reperfusion. Fragmented QRS is associated with increased adverse cardiovascular events, it was proved to bea marker of ventricular dysfunction and poor prognosis in STEMI. Aim: To study the relation between QRS fragmentations and the degree of myocardial reperfusion in patients with STEMI treated with either fibrinolytic therapy or primary percutaneous coronary interventions (1ry PCI). Patients and methods: 100 subjects admitted with first attack of STEMI were included. Twelve leads ECGs were evaluated for QRS morphology, patients were randomized in two groups according to presence or absence of QRS fragmentation, fragmented QRS (F-QRS) group included 35 patients and non fragmented QRS (NF-QRS) group included 65 patients. The following parameters were used to assess the success of coronary reperfusion; ST segment resolution, thrombolysis in myocardial Infarction coronary grade flow (TIMI score), myocardial blush grades (MBG) score and cardiac enzymes resolution. Results: ST segment resolution score was significantly higher among NF-QRS t. NFQRS group had better myocardial blush grades and TIMI scores compared with patients with F-QRS group. F-QRS was significantly associated with lower EF and higher Klipp score. CKmb was significantly higher among F-QRS group. Complications were significantly higher among patients with F-QRS. Conclusion: QRS fragmentation can be a reliable predictor of coronary reperfusion in patients with acute STEMI treated with primary percutaneous coronary interventions or thrombolytic therapy.
背景:ST段抬高型心肌梗死(STEMI)治疗的主要目标是恢复冠状动脉血流,维持心肌灌注。包括心电图和冠状动脉造影参数在内的几种工具用于评估心肌再灌注。碎片化QRS与心血管不良事件增加相关,已被证明是STEMI患者心室功能障碍和预后不良的标志。目的:探讨经纤溶治疗或经皮冠状动脉介入治疗(PCI)的STEMI患者QRS片段与心肌再灌注程度的关系。患者和方法:纳入首次发作STEMI患者100例。对12例导联心电图进行QRS形态学评价,根据是否存在QRS碎片性随机分为两组,碎片性QRS (F-QRS)组35例,非碎片性QRS (NF-QRS)组65例。采用以下参数评价冠状动脉再灌注成功与否;ST段分辨率,心肌梗死溶栓冠状动脉分级血流(TIMI评分),心肌红晕分级(MBG)评分和心肌酶分辨率。结果:NF-QRS组患者ST段分辨力评分显著高于F-QRS组,NFQRS组患者心肌红度评分和TIMI评分均优于F-QRS组。F-QRS与较低的EF和较高的Klipp评分显著相关。F-QRS组CKmb明显增高。F-QRS患者的并发症明显增多。结论:QRS片段可作为急性STEMI患者经皮冠状动脉介入治疗或溶栓治疗的可靠预测指标。
{"title":"Value of QRS fragmentation as novel electrocardiogram predictor of reperfusion in acute myocardial infarction patient","authors":"Hoda M. Sobh, N. Awad, Mohamed Adel Omar","doi":"10.58775/2735-3990.1380","DOIUrl":"https://doi.org/10.58775/2735-3990.1380","url":null,"abstract":"Background: The main target of treatment of ST elevation myocardial infarction (STEMI) is to restore coronary blood flow and maintain myocardial perfusion. Several tools including electrocardiographic and coronary angiographic parameters are used to assess myocardial reperfusion. Fragmented QRS is associated with increased adverse cardiovascular events, it was proved to bea marker of ventricular dysfunction and poor prognosis in STEMI. Aim: To study the relation between QRS fragmentations and the degree of myocardial reperfusion in patients with STEMI treated with either fibrinolytic therapy or primary percutaneous coronary interventions (1ry PCI). Patients and methods: 100 subjects admitted with first attack of STEMI were included. Twelve leads ECGs were evaluated for QRS morphology, patients were randomized in two groups according to presence or absence of QRS fragmentation, fragmented QRS (F-QRS) group included 35 patients and non fragmented QRS (NF-QRS) group included 65 patients. The following parameters were used to assess the success of coronary reperfusion; ST segment resolution, thrombolysis in myocardial Infarction coronary grade flow (TIMI score), myocardial blush grades (MBG) score and cardiac enzymes resolution. Results: ST segment resolution score was significantly higher among NF-QRS t. NFQRS group had better myocardial blush grades and TIMI scores compared with patients with F-QRS group. F-QRS was significantly associated with lower EF and higher Klipp score. CKmb was significantly higher among F-QRS group. Complications were significantly higher among patients with F-QRS. Conclusion: QRS fragmentation can be a reliable predictor of coronary reperfusion in patients with acute STEMI treated with primary percutaneous coronary interventions or thrombolytic therapy.","PeriodicalId":18173,"journal":{"name":"Mansoura Veterinary Medical Journal","volume":"295 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75110230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Mansoura Veterinary Medical Journal
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