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Female Fertility Preservation: Current & Future Strategies 女性生育能力保存:当前和未来的策略
Pub Date : 2022-09-01 DOI: 10.21608/mjmu.2022.128323.1068
Nouran Sallam, R. Hemida
Recently, the spectacular progress in diagnosis, treatment, and prognosis of different malignancies has increased the demands on fertility preservation. Fertility impairment is considered one of the complications of radio/cytotoxic treatments in females who managed to overcome their cancer. This issue of fertility preservation also concerns those who are at risk of developing ovarian failure as well as healthy individuals who aim to overcome age-related fertility decline. Regarding female fertility preservation, there are various options that could be selected according to various factors, including the patient’s age, type of the disease, as well as type and urgency of treatment. Among these options, embryo/oocyte cryopreservation as well as ovarian tissue cryopreservation and autotransplantation are the most reliable modalities for post- and pre- pubertal patients, respectively. Moreover, novel techniques such as the artificial ovary, isolation and cryopreservation of follicles and immature oocyte, potential pharmacological gonadoprotective agents, and stem cells transplantation have the potential to be used in the future. In this article, current and future female fertility preservation strategies are highlighted .
近年来,各种恶性肿瘤的诊断、治疗和预后都取得了惊人的进展,这增加了对生育能力保存的要求。生育障碍被认为是成功战胜癌症的女性放射/细胞毒性治疗的并发症之一。保留生育能力的问题也涉及那些有卵巢功能衰竭风险的人,以及旨在克服与年龄有关的生育能力下降的健康个体。关于保留女性生育能力,可根据各种因素选择各种方案,包括患者的年龄、疾病类型以及治疗的类型和紧迫性。在这些选择中,胚胎/卵母细胞冷冻保存以及卵巢组织冷冻保存和自体移植分别是青春期后和青春期前患者最可靠的方式。此外,人工卵巢、卵泡和未成熟卵母细胞的分离和冷冻保存、潜在的药理学性腺保护剂和干细胞移植等新技术在未来也有应用的潜力。本文重点介绍了当前和未来的女性生育保护策略。
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引用次数: 0
The polyunsaturated fatty acid profile in erythrocyte cell membranes among group of Egyptian rheumatoid arthritis patients 埃及类风湿关节炎患者红细胞膜多不饱和脂肪酸谱
Pub Date : 2022-09-01 DOI: 10.21608/mjmu.2022.145254.1123
D. Elseady, E. Hafez, A. Elghaweet, A. Negm
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引用次数: 0
Assessment the effect of doramectin on female rat fertility 评价多拉菌素对雌性大鼠生育能力的影响
Pub Date : 2022-09-01 DOI: 10.21608/mvmj.2022.151764.1117
S. Elsayed, A. Elsayed, R. El-shafei, M. Gabr
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引用次数: 0
Shelf-life extension and Campylobacter jejuni inhibition by application of zinc oxide Nanoparticles in chicken fillets 氧化锌纳米颗粒在鸡块中的应用延长了货架期并抑制了空肠弯曲杆菌
Pub Date : 2022-07-24 DOI: 10.21608/mvmj.2022.149827.1116
Amina Elrais, Reyad rabea, Wlaa Abdel Megid, M. Abdallah, Walid sobhy Arab
ABSTRACT
摘要
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引用次数: 0
Potential Effects of Vitamin D and Resveratrol on Hematological and Renal Indicators Associated with Metabolic Syndrome in Rats 维生素D和白藜芦醇对代谢综合征大鼠血液学和肾脏指标的潜在影响
Pub Date : 2022-07-08 DOI: 10.21608/mvmj.2022.142976.1114
Doha Arafa, Gehad Elshobaky, E. Risha, F. Abdelhamid
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引用次数: 0
Pathotyping of Field Identified Newcastle Disease Isolated from Quail in Egypt 埃及鹌鹑野外鉴定新城疫的病原分型研究
Pub Date : 2022-06-06 DOI: 10.21608/mvmj.2022.127681.1109
M. Lebdah, S. Abdelrahman, N. Awad, Reham Karam, A. Attia, Mohamed Ibrahim El bagoury
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引用次数: 0
Serum level of Interleukin-33 and relation to disease activity in Juvenile Idiopathic Arthritis 青少年特发性关节炎患者血清白细胞介素-33水平及其与疾病活动性的关系
Pub Date : 2022-06-01 DOI: 10.21608/mjmu.2022.121843.1054
Zeinab Zeid, E. Eltoraby, A. Abdelsalam, Y. Mosaad, S. Tharwat
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引用次数: 0
Pre-attentive auditory responses in multiple sclerosis patients 多发性硬化症患者的前注意听觉反应
Pub Date : 2022-06-01 DOI: 10.21608/mjmu.2022.118801.1052
wesam eshawaf, Tamer Belal, hanan ellithy, Mohamed abeltawab, shahat elshokary
Background :MS is characterized by impairment in cognitive domains. Sensory memory is one of the cognitive domains affected in MS. MMN allows the brain to detect (via a comparator mechanism) deviant events occurring within a stream of repetitive stimuli. The amplitude and latency of the MMN has been used to elucidate the nature of the sensory memory upon which it is based. Aim: This work was designed to evaluate and measure the MMN test results as regard its amplitude and latency in MS patients and to compare the results with normal age and gender matched control group in an attempt to declare the diagnostic and prognostic value of MMN in MS patients. Methods : Forty patients with multiple sclerosis (MS) were diagnosed and referred from the Neurology department. All participants in this study (forty MS patients and forty healthy subjects' sex and age-matched with MS patients) were subjected to basic audiological evaluation, mismatch negativity (MMN) recording using oddball paradigm with frequency variation, and Expanded disability status scale (EDSS) for MS patients. MMN amplitude and latency were measured in both MS patients and control subjects. MMN results were compared to MS and healthy control. Also, EDSS was measured in MS patients. The forty MS patients are divided into two subgroups: MS patients who produced an MMN wave and MS with absent MMN compared to the demographic data of both subsets. Results: A significant difference between the two subgroups in the duration of MS diagnosis was present. Also, there was a substantial difference between groups in sex. The subgroup with absent MMS was all male. Meanwhile, no considerable difference between both groups as regards age and EDSS. There is no difference in MMN latency and amplitude between MS patients with preserved MMN and control groups. Twenty percent of our MS patients have absent MMN, which is all-male reflecting cognitive impairment, cognitive fatigue, or central processing disorders. In contrast, there is no difference in latency and amplitude between recorded MMN in the study and control groups. Conclusions: The absence of MMN in some MS patients suggests affection of the central auditory processing abilities measured by MMN in those patients which need further research
背景:多发性硬化症以认知功能障碍为特征。感觉记忆是多发性硬化症中受影响的认知领域之一。MMN允许大脑检测(通过比较机制)重复刺激流中发生的异常事件。MMN的振幅和潜伏期已被用来阐明它所基于的感觉记忆的性质。目的:本工作旨在评价和测量多发性硬化症患者MMN检测结果的幅度和潜伏期,并将结果与正常年龄和性别匹配的对照组进行比较,试图阐明MMN在多发性硬化症患者中的诊断和预后价值。方法:对40例多发性硬化症(MS)患者进行回顾性分析。本研究对所有被试(40名MS患者和40名性别、年龄与MS患者相匹配的健康受试者)进行了基本听力学评估、频率变异的错配阴性(MMN)记录和MS患者的扩展残疾状态量表(EDSS)。测量MS患者和对照组MMN振幅和潜伏期。MMN结果与MS和健康对照进行比较。此外,还测量了MS患者的EDSS。将40例多发性硬化症患者分为两个亚组:产生MMN波的多发性硬化症患者和没有MMN的多发性硬化症患者,并对这两个亚组的人口统计数据进行比较。结果:两个亚组在MS诊断时间上存在显著差异。此外,两组之间在性别上也有很大的差异。MMS缺失亚组均为男性。同时,两组在年龄和EDSS方面无显著差异。保留MMN的MS患者与对照组MMN潜伏期和振幅无差异。20%的多发性硬化症患者没有MMN,这反映了认知障碍、认知疲劳或中枢处理障碍。相比之下,实验组和对照组记录的MMN在潜伏期和振幅上没有差异。结论:部分多发性硬化症患者MMN缺失提示MMN测量的中枢听觉加工能力受到影响,值得进一步研究
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引用次数: 0
Application of HACCP system to food preparation and services kitchens in Mansoura University hostels HACCP系统在曼苏拉大学宿舍食品准备和服务厨房的应用
Pub Date : 2022-06-01 DOI: 10.21608/mvmj.2022.123579.1106
Radwa assy
Objective: to assess to what extent the food safety principles of the Hazard Analysis Critical Control Points (HACCP) were applied at all Mansoura university hostels. Design : Descriptive study. Procedures: This was carried out through using a food safety checklist (49 attributes covering receiving, storing, preparation, cooking, holding and serving processes) and also through determining the microbiol quality of 100 samples from sterile milk, yoghurt, tabled egg and processed cheese (25 each) that were collected haphazardly from breakfast and dinner meals in Mansoura University hostels, with special reference to total bacterial and coliform count and isolation of Escherichia coli, Salmonella and Staphylococcus aureus which were identified by conventional bacteriological techniques and further confirmed microscopically and serologically. Results: The finding of the observation checklist revealed that El Gomhoria city achieved the highest score (75.51%) in all investigated dimensions. On the contrary Al Amal was (55.1%), Gehan was (55.1%) and Al Zahraa was (54.42%) obtained the lowest score. The highest total bacterial count was in plain yogurt samples, followed by processed cheese samples then table egg samples, while the lowest total bacterial count was in sterile milk samples. On the other hand, the highest total coliform count was found in processed cheese samples, followed by table egg samples then plain yogurt samples, and sterile milk samples. These results were not compatible with the Egyptian standard (2005). Also, E. coli was found in 40% of the table egg samples which represent the highest percentage, Salmonella was found in 32% of processed cheese samples, and S. aureus was found in 40% of table egg samples. While sterile milk samples were free from E. coli, Salmonella species, and S. aureus . Conclusion and clinical relevance: T he general sanitary conditions concerning the production and handling of milk, dairy products and table eggs frequently introduced to the resident in Mansoura University hostels should be monitored.
目的:评价危害分析关键控制点(HACCP)食品安全原则在曼苏拉所有大学宿舍的应用程度。设计:描述性研究。程序:这是通过使用食品安全清单(包括接收、储存、准备、烹饪、保存和服务过程的49个属性)以及通过确定从曼苏拉大学宿舍的早餐和晚餐中随机收集的100个无菌牛奶、酸奶、鸡蛋和加工奶酪样品(各25个)的微生物质量来进行的,特别参考了细菌总数和大肠菌群计数以及大肠杆菌的分离。沙门氏菌和金黄色葡萄球菌经常规细菌学方法鉴定,镜检和血清学进一步证实。结果:观察表显示,El Gomhoria市在所有调查维度中得分最高(75.51%)。Al Amal(55.1%)、Gehan(55.1%)和Al Zahraa(54.42%)得分最低。细菌总数最高的是纯酸奶样品,其次是加工奶酪样品,然后是食用鸡蛋样品,而细菌总数最低的是无菌牛奶样品。另一方面,大肠菌群总数最高的是加工奶酪样品,其次是食用鸡蛋样品,然后是原味酸奶样品,最后是无菌牛奶样品。这些结果不符合埃及标准(2005)。此外,在40%的食用鸡蛋样本中发现了大肠杆菌,这是最高的比例,在32%的加工奶酪样本中发现了沙门氏菌,在40%的食用鸡蛋样本中发现了金黄色葡萄球菌。而无菌牛奶样品则不含大肠杆菌、沙门氏菌和金黄色葡萄球菌。结论和临床意义:应监测曼苏拉大学宿舍居民经常接触的牛奶、乳制品和食用鸡蛋的生产和处理的一般卫生条件。
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引用次数: 0
Apilot study Impact of glucocorticoid receptor gene polymorphism on the metabolic profile of child patients with classical form of 21-hydroxylase deficiency 糖皮质激素受体基因多态性对经典21-羟化酶缺乏症儿童患者代谢谱的影响
Pub Date : 2022-06-01 DOI: 10.21608/mjmu.2022.126765.1057
Karema ali, M. Shokeir, N. Salem
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引用次数: 0
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Mansoura Veterinary Medical Journal
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