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Targeted Axillary Dissection In Breast Cancer Patients After Neoadjuvant Therapy 乳腺癌患者在新辅助治疗后的腋窝清扫
Pub Date : 2022-12-01 DOI: 10.21608/mjmu.2022.129215.1088
Youssef El Sabbagh, O. Hamdy
In the last 20 years, axillary surgery for breast cancer has changed dramatically. In clinically node-positive patients, ALND is the conventional procedure. With the development of efficient neo-adjuvant chemotherapy (NACT), there is a shift toward less aggressive operation in patients who have clinical signs of excellent response and disease shrinkage. Therefore, SLN biopsy (SLNB), which offers an accurate, less morbid staging procedure that prevents complications of ALND has become the standard technique in node negative early breast cancer. In these patients, However, there has been a reluctance to perform (SLNB) after completion of NACT in patients with histologically proven axillary metastases because of false-negative rates (FNRs) greater than 10%. To deal with this problem, a new and promising technique called targeted axillary dissection (TAD) has been developed for determining axillary status in postneoadjuvant chemotherapy (NACT) node-positive breast cancer patients. It includes removal of the SLN as well as the pathologically proven positive nodes which have to be marked before starting the NACT. TAD can be considered a practical, reproducible, and valid method for ruling out metastatic axillary involvement in patients with breast cancer who have had a favourable response to NACT
在过去的20年里,腋窝手术治疗乳腺癌的方法发生了巨大的变化。在临床淋巴结阳性患者中,ALND是常规手术。随着高效的新辅助化疗(NACT)的发展,对于有良好反应和疾病缩小的临床症状的患者,有一种向低侵袭性手术的转变。因此,SLN活检(SLNB)提供了一个准确的、较少病态的分期程序,可以防止ALND的并发症,已成为淋巴结阴性早期乳腺癌的标准技术。然而,在这些患者中,由于假阴性率(FNRs)大于10%,组织学证实腋窝转移的患者在完成NACT后不愿进行SLNB。为了解决这一问题,一种新的有前途的技术被称为靶向腋窝解剖(TAD),用于确定新辅助化疗后淋巴结阳性乳腺癌患者的腋窝状态。它包括切除SLN以及在开始NACT之前必须标记的病理证实的阳性淋巴结。对于对NACT有良好反应的乳腺癌患者,TAD可以被认为是一种实用、可重复和有效的方法,用于排除转移性腋窝累及
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引用次数: 0
An Update on the Outcome of Primary Cleft Rhinoplasty 原发性鼻裂成形术疗效的最新进展
Pub Date : 2022-12-01 DOI: 10.21608/mjmu.2022.128482.1070
ِEsraa Elamli, M. E. El Fahar
Primary cleft rhinoplasty has been a topic of interest over the decades. The cleft nasal deformities challenge all plastic surgeons. There is significant variability in the anatomy of each cleft deformity, but iatrogenic changes and scarring from the previous surgeries add another layer of complexity. There are lots of techniques described to address such deformities. These techniques were further refined and modified over time, but no one protocol is reported to be entirely satisfactory. A perfect nose with no deformity is unusual, but reasonably good results are achieved when the principles of nasal repair are fully applied. Moreover, there is still paucity in the outcomes reported, which makes it harder to evaluate the results of the primary rhinoplasty. And, even the few reported results are not evaluated according to standardized methods, making the evaluation subjective. This work aims to review recent literature on long-term primary rhinoplasty outcomes of unilateral cleft lip.
原发性鼻裂成形术几十年来一直是人们感兴趣的话题。鼻裂畸形是所有整形外科医生的难题。每一种唇裂畸形的解剖结构都有很大的差异,但医源性的改变和以前手术留下的疤痕又增加了一层复杂性。有很多技术描述来解决这种畸形。随着时间的推移,这些技术被进一步改进和修改,但据报道,没有一种方案是完全令人满意的。一个没有畸形的完美鼻子是不寻常的,但是当鼻子修复的原则完全应用时,可以获得相当好的结果。此外,报告的结果仍然缺乏,这使得对初次鼻整形的结果进行评估变得更加困难。而且,即使是少数报告的结果也没有按照标准化的方法进行评估,使评估变得主观。这项工作的目的是回顾最近的文献长期初级鼻整形单侧唇裂的结果。
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引用次数: 0
Dynamics of spontaneous heart rate turbulence in patients with pure chronic aortic regurgitation 单纯慢性主动脉瓣反流患者的自发性心率乱流动力学
Pub Date : 2022-12-01 DOI: 10.21608/mjmu.2022.160761.1142
Hoda M. Sobh, maged zaghlool, insaf elnady, ahmed hataha
Background: Biphasic responses to ventricular premature contractions (VPCs) cause heart rate turbulence (HRT), which is primarily mediated by the baroreceptors. HRT is useful for cardiovascular risk stratification of different cardiac diseases. Aim and objectives: The purpose of this research was to analyze HRT in patients with chronic Aortic regurgitation (AR) and determine whether there is a correlation between HRT parameters and echocardiographic data. Subjects and methods: This case control study was carried out in Specialized Medical Hospital, Cardiology Department, Mansoura University on 30 aortic regurgitation patients and other 30 control individuals. HRT parameters were compared in both groups. Result: There was a positive correlation between turbulence slope (TS) and ejection fraction (EF), Fractional shortening (FS). There was a positive correlation between turbulence onset (TO) and min heart rate (HR), and TS with time domain SDANN. Conclusion: Patients with chronic AR had significantly impaired HRT parameters compared to normal subjects.
背景:室性早搏(VPCs)的双相反应引起心率震荡(HRT),其主要由压力感受器介导。HRT对不同心脏疾病的心血管危险分层是有用的。目的和目的:本研究的目的是分析慢性主动脉瓣反流(AR)患者的HRT治疗,并确定HRT参数与超声心动图数据之间是否存在相关性。对象与方法:选取曼苏拉大学附属专科医院心内科主动脉瓣返流患者30例,对照组30例。比较两组HRT参数。结果:湍流斜率(TS)与弹射分数(EF)、分数缩短(FS)呈正相关。湍流发作(TO)与最小心率(HR)呈正相关,TS与时域SDANN呈正相关。结论:与正常人相比,慢性AR患者HRT参数明显受损。
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引用次数: 0
Shigatoxin producing Escherichia coli in camel meat marketed in Behaira Governorate, Egypt. 埃及比赫拉省销售的驼肉中产生志贺毒素的大肠杆菌。
Pub Date : 2022-09-30 DOI: 10.21608/mvmj.2022.160381.1120
Yasmine Ibrahim, Khalid Sallam, H. Zaher, Mohamed Elgazar
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引用次数: 0
Differentiation and classification of productive efficiency of chicken farms using logistic regression and linear discriminant analysis 运用logistic回归和线性判别分析对养鸡场生产效率进行区分和分类
Pub Date : 2022-09-27 DOI: 10.21608/mvmj.2022.162138.1121
Eman A. Abo Elfadl, H. Radwan, U. Abou-Ismail
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引用次数: 0
Effects of L arginine supplementation on in-vitro maturation and cryotolerance of immature buffalo oocyte 补充L精氨酸对未成熟水牛卵母细胞体外成熟和低温耐受性的影响
Pub Date : 2022-09-24 DOI: 10.21608/mvmj.2022.120462.1102
Mohamed K. Abdeldayem, S. Zaabel, Magdy‎ Badr, Heba A Sharawy, Amira Mostagir, Fatma Adlan, R. Saleh, M. Elmetwally
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引用次数: 0
Prevalence, genetic characterization, and antibiogram of Salmonella enterica recovered from buffalo meat 从水牛肉中恢复的肠沙门氏菌的流行、遗传特征和抗生素谱
Pub Date : 2022-09-18 DOI: 10.21608/mvmj.2022.160242.1119
T. Fathy, Amira I. Zakaria, S. Abd-Elghany, K. Sallam
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引用次数: 0
The Value of D-Dimer Blood Concentrations in Prediction of Presence of Left Atrial Thrombus in Patients with non-valvular Atrial Fibrillation d -二聚体血药浓度对非瓣膜性心房颤动患者左房血栓存在的预测价值
Pub Date : 2022-09-01 DOI: 10.21608/mjmu.2022.132170.1094
A. bedier, Sally Teima, A. Elshal
Background: Atrial fibrillation (AF) is the most typical sustained cardiac disturbance all over the world, it increases the risk of left atrial (LA) thrombus, Plasma fibrin D-dimers seems to be a helpful parameter for assessing the degrees of hypercoagulability. Higher risk of recurrent ischemic stroke was found to be associated with baseline elevated D-dimers levels. Aim: To assess the value of D-Dimer examination in prediction of presence of LA thrombus in patients with AF instead of transesophageal echocardiography (TEE) examination. Patients and Methods: Analytical cross-sectional study was conducted. It included 250 patients divided according to presence of LA thrombus into two groups; group without LA thrombus (n=224), and group with LA thrombus (n=26), referred to cardiology department, Mansoura Specialized Medicine Hospital. History was taken, blood was collected for D-dimer testing on the same day of the TEE. Results: CHADS2-VASc, Heart failure, Diastolic dysfunction, D-dimers (ng/mL), D Dimer more than 500 ng/mL, and D Dimer more than 10×patient’s age have positive and statistically significant impact on LA thrombus formation. Similarly, Paroxysmal AF and left ventricle ejection fraction (%) had negative and statistically significant impact on LA thrombus formation. The optimal cutoff point of D-dimers was 1247.9 (ng/mL), its accuracy was 86.4%, (AUC = 0.711) with sensitivity (50%) and specificity (90.6%). Conclusion: D-dimer can be beneficial in clinical practice to exclude LA thrombus avoiding TEE, particularly in patients with low thromboembolic risk such as normal left atrial dimensions, no previous attacks of AF, no valvular heart disease, female patient, CHAD2VASC score less than 2 and no history of thromboembolic attacks.
背景:房颤(AF)是世界上最典型的持续性心脏疾患,它增加了左房血栓的发生风险,血浆纤维蛋白d -二聚体似乎是评价高凝程度的一个有用参数。研究发现,复发性缺血性卒中的高风险与基线d -二聚体水平升高有关。目的:评价d -二聚体检查替代经食管超声心动图(TEE)检查预测房颤患者LA血栓存在的价值。患者和方法:采用横断面分析研究。250例患者根据有无LA血栓分为两组;无LA血栓组(n=224)和有LA血栓组(n=26),转至曼苏拉市专科医院心内科。采集病史,于TEE当日采血进行d -二聚体检测。结果:CHADS2-VASc、心力衰竭、舒张功能不全、D-二聚体(ng/mL)、D-二聚体> 500 ng/mL、D-二聚体> 10×patient年龄对LA血栓形成有正影响,且有统计学意义。同样,阵发性房颤和左心室射血分数(%)对左室血栓形成有负的、有统计学意义的影响。d -二聚体的最佳截断点为1247.9 (ng/mL),准确度为86.4% (AUC = 0.711),灵敏度为50%,特异性为90.6%。结论:d -二聚体可用于临床排除LA血栓避免TEE,特别是对于左房尺寸正常、既往无房颤发作、无瓣膜性心脏病、女性患者、CHAD2VASC评分小于2分、无血栓栓塞发作史等血栓栓塞风险低的患者。
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引用次数: 0
Invasive Fungal Sinusitis Associated with COVID-19 与COVID-19相关的侵袭性真菌鼻窦炎
Pub Date : 2022-09-01 DOI: 10.21608/mjmu.2022.129792.1092
heba aldegla, Ali Elzar, A. Eldeeb
According to WHO Coronavirus (COVID-19) Dashboard, as of 11 th February 2022, there have been 404,910,528 confirmed cases of COVID-19, including 5,783,776 deaths. Coronavirus-2 (SARS-CoV-2) is the causative agent. It is caused by coronavirus-2 (SARS-CoV-2), the disease may cause acute respiratory distress syndrome (ARDS), that increases the susceptibility of co-infections with fungi. Acute invasive fungal sinusitis (AIFS) is a severe infection mostly affecting immune-compromised patients and carries high risk of mortality. COVID-19 patients admitted to the ICU have risk factors for AIFS, mainly chronic diseases of the respiratory tract, treatment with corticosteroid, intubation/mechanical ventilation, and cytokine storm. Aspergillus and Mucorales are the causative fungi of most AIFS cases, but other atypical fungi can be involved especially among patients receiving azole prophylaxis. Most AIFS cases have symptoms like fever, nasal congestion, and facial swelling. Diagnosis of AIFS is made by endoscopy and radiology associated with clinical examination. The gold standard test for diagnosis of AIFS is histopathology, though pan-fungal PCR plays an important role. Therapy of AIFS includes surgery, antifungal agents, and correction of immunosuppression status
根据世卫组织冠状病毒(COVID-19)仪表板,截至2022年2月11日,已有404,910,528例COVID-19确诊病例,其中5,783,776例死亡。冠状病毒-2 (SARS-CoV-2)是病原体。它是由冠状病毒-2 (SARS-CoV-2)引起的,该疾病可引起急性呼吸窘迫综合征(ARDS),这增加了与真菌合并感染的易感性。急性侵袭性真菌鼻窦炎(AIFS)是一种严重的感染,主要影响免疫功能低下患者,具有很高的死亡率。入住ICU的COVID-19患者存在AIFS的危险因素,主要是呼吸道慢性疾病、皮质类固醇治疗、插管/机械通气和细胞因子风暴。曲霉和毛霉菌是大多数AIFS病例的致病真菌,但其他非典型真菌也可能涉及,特别是在接受唑预防的患者中。大多数AIFS病例都有发烧、鼻塞和面部肿胀等症状。AIFS的诊断是通过内窥镜和放射学结合临床检查。诊断AIFS的金标准测试是组织病理学,尽管泛真菌PCR也起着重要作用。AIFS的治疗包括手术、抗真菌药物和纠正免疫抑制状态
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引用次数: 0
Chordoid Meningioma: Clinical, Hsitopathological and Radiological Study 脊索样脑膜瘤:临床、病理及放射学研究
Pub Date : 2022-09-01 DOI: 10.21608/mjmu.2022.150095.1128
Mohamed M Elsherbini, M. Elhawary, K. Ali, A. Elmokadem, A. Khalil, M. Elshirbiny
The purpose of this study is to discuss the clinical, radiological and histopathological features of a rare grade 2 variant of meningioma. Patients and methods: A retrospective analysis of the data of 6 patients who underwent surgery for a histopathologically proven chodroid meningioma. Results: Six patients’ pathology reports showed chordoid meningioma. On imaging, four lesions (67%) were isointense in T1 while the other two were hypointense. On T2 weighted images, four patients were hyperintense (67%) and displayed non-restricted diffusion pattern with elevated values on corresponding apparent diffusion coefficient maps. Pathologically, chordoid elements varied vastly among cases, radiological characters corresponded to choroid elements in all cases. Conclusion: choirdoid meningioma, as a rare meningioma entity, should be suspected pre-operatively in cases with high signal intensity in T2, homogenous enhancement and increased apparent diffusion coefficient, gross total surgical excision is curative.
本研究的目的是讨论一种罕见的2级脑膜瘤的临床、放射学和组织病理学特征。患者和方法:回顾性分析6例经组织病理学证实的脊膜样脑膜瘤手术患者的资料。结果:6例患者病理表现为脊索样脑膜瘤。在影像学上,4个病变(67%)在T1时呈等强度,另外2个呈低强度。T2加权图像上,4例患者呈高信号(67%),呈非限制性弥散模式,相应的表观弥散系数图值升高。病理上,不同病例的脉络膜元素差异很大,放射学特征与所有病例的脉络膜元素相对应。结论:脉络膜样脑膜瘤是一种罕见的脑膜瘤实体,术前应怀疑T2高信号,均质强化,视扩散系数增高,手术切除可治愈。
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引用次数: 1
期刊
Mansoura Veterinary Medical Journal
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