Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.01
B. Syed
Telomere length is an indicator of biological age, influenced mainly by oxidative stress and inflammatory conditions. Telomere length shortens with advancing age, however in certain situations this shortening expedites with early senile changes while in other situations it can be delayed resulting in slowing of ageing. Ageing is a factor associated with a number of diseases and also treatment decision of lethal diseases is directly influenced by the age. However, understanding the difference of chorological versus biological age is essential. It is also essential to determine cut-offs of the age by using telomere length.
{"title":"Telomere length- A biological marker of ageing","authors":"B. Syed","doi":"10.38106/lmrj.2023.5.1.01","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.01","url":null,"abstract":"Telomere length is an indicator of biological age, influenced mainly by oxidative stress and inflammatory conditions. Telomere length shortens with advancing age, however in certain situations this shortening expedites with early senile changes while in other situations it can be delayed resulting in slowing of ageing. Ageing is a factor associated with a number of diseases and also treatment decision of lethal diseases is directly influenced by the age. However, understanding the difference of chorological versus biological age is essential. It is also essential to determine cut-offs of the age by using telomere length.\u0000 ","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125712077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.05
M. Panhwar, Ambreena Qureshi, Pirya Nangdev, Qasier Ali Baig, Madiha shams, Hamna Sikandar
Pakistani population is ranked number 3rd in the prevalence of diabetes after India and China. Its self-management has been considered a keystone for the care of the disease. It is imperative to take measures that can help diabetic patients to maintain self-management. Recent advancements in the field of information technology, such as digital applications, might help to create a platform for delivering and managing self-care interventions that would be easily accessible. Thus, this study was designed to evaluate the frequency of utilization of smartphone technology for self-care. A multi-centric, cross-sectional study was conducted. The results of the study showed that most patients use smartphones but only a few users were aware of health applications for self-care of diabetes. Most patients were using health applications for their self-management only when they are in need. In conclusion, most patients in Pakistan use smart phone but they do not utilise health care mobile applications appropriately due to the lack of awareness. Given the increasing number of patients it is essential to provide public health awareness regarding use of these applications so that patients can manage their glycaemic control at home with convenience. This will also reduce burden on health care system.
{"title":"Assessment of usage of Mobile Applications for self-care in Diabetic Patients attending dental OPD A preliminary study","authors":"M. Panhwar, Ambreena Qureshi, Pirya Nangdev, Qasier Ali Baig, Madiha shams, Hamna Sikandar","doi":"10.38106/lmrj.2023.5.1.05","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.05","url":null,"abstract":"Pakistani population is ranked number 3rd in the prevalence of diabetes after India and China. Its self-management has been considered a keystone for the care of the disease. It is imperative to take measures that can help diabetic patients to maintain self-management. Recent advancements in the field of information technology, such as digital applications, might help to create a platform for delivering and managing self-care interventions that would be easily accessible. Thus, this study was designed to evaluate the frequency of utilization of smartphone technology for self-care. A multi-centric, cross-sectional study was conducted. The results of the study showed that most patients use smartphones but only a few users were aware of health applications for self-care of diabetes. Most patients were using health applications for their self-management only when they are in need. In conclusion, most patients in Pakistan use smart phone but they do not utilise health care mobile applications appropriately due to the lack of awareness. Given the increasing number of patients it is essential to provide public health awareness regarding use of these applications so that patients can manage their glycaemic control at home with convenience. This will also reduce burden on health care system.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116197615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.06
Muhammad Mubashir Shah, Abdullah Dayo, Ubed ur Rahman Mughal, Nabeela Latif, Nargis Saharan
Asthma is a common allergic reaction and a number of drugs are available. This study was conducted to evaluate the prescribing pattern and usage of anti-asthma medications at different medical setups in Hyderabad. The study was conducted from August 2017 to July 2018. A total of 1000 patients from different medical setups diagnosed with asthma were recruited. A pre-designed, detailed questionnaire was used for their data collection. Their prescriptions were collected to evaluate and compare them with the standard guidelines of GINA. The prescribing pattern of anti-asthma was assessed regarding the type of therapy, route of administration, single or multiple treatments, class of drugs, doses, and frequency. Demographically, more asthmatics were found be males (i.e 73.5%), 46.5% were adults, 58.3% from urban areas and 51.68% of the sample had outdoor jobs, while 41.5% of illiterate people were found to be asthmatic. A major type of asthma was persistent at 65.3%. A maximum prescription of 85.5% for asthma management was combined therapy. From long-term use, the monotherapy ICS group was reported in a considerable number (44.13%) (i.e. Beclomethasone in 70% and Budesonide in 7%). Prescriptions of multiple routes of administration were comparatively higher (79.5%). The study concluded that male, young, urban, illiterate and people with outdoor jobs were more likely to get asthma. Preventer drugs were prescribed more in combined therapy, in which Fluticasone + Salmeterol were preferred. The oral inhalational route was selected more. The treatment pattern was consistent with standard guidelines.
{"title":"Evaluation of pattern of prescription for Asthma : A multicentre prospective observational study from Pakistan","authors":"Muhammad Mubashir Shah, Abdullah Dayo, Ubed ur Rahman Mughal, Nabeela Latif, Nargis Saharan","doi":"10.38106/lmrj.2023.5.1.06","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.06","url":null,"abstract":"Asthma is a common allergic reaction and a number of drugs are available. This study was conducted to evaluate the prescribing pattern and usage of anti-asthma medications at different medical setups in Hyderabad. The study was conducted from August 2017 to July 2018. A total of 1000 patients from different medical setups diagnosed with asthma were recruited. A pre-designed, detailed questionnaire was used for their data collection. Their prescriptions were collected to evaluate and compare them with the standard guidelines of GINA. The prescribing pattern of anti-asthma was assessed regarding the type of therapy, route of administration, single or multiple treatments, class of drugs, doses, and frequency. Demographically, more asthmatics were found be males (i.e 73.5%), 46.5% were adults, 58.3% from urban areas and 51.68% of the sample had outdoor jobs, while 41.5% of illiterate people were found to be asthmatic. A major type of asthma was persistent at 65.3%. A maximum prescription of 85.5% for asthma management was combined therapy. From long-term use, the monotherapy ICS group was reported in a considerable number (44.13%) (i.e. Beclomethasone in 70% and Budesonide in 7%). Prescriptions of multiple routes of administration were comparatively higher (79.5%). The study concluded that male, young, urban, illiterate and people with outdoor jobs were more likely to get asthma. Preventer drugs were prescribed more in combined therapy, in which Fluticasone + Salmeterol were preferred. The oral inhalational route was selected more. The treatment pattern was consistent with standard guidelines.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126796035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.03
F. Shah, Fasiha Shah, Shaista Ehsan, Nabia Shah
Mother feed (i.e. Breast feeding) provides essential nutrients, antibodies and immune cells to allow infant growth and protect them from infections. Mother feed not only have short term effects but it influences brain development as well as life time effects in many organ systems. This study was conducted to compare mother feed and bottle feed children at school going age. The self-administrated questionnaire survey was conducted including parents of children between 5 to 10 years of age (n=300). There was no significant difference found in the median age of children reported for, neither there was any significant difference in the weight of the two groups. However, bottle feed children significantly showed better performance in mathematics while mother feed children were significantly better in general science and physical activities at school. The study concluded that bottle feed or breast feed both provides nutrition and overall children were doing good.
{"title":"Bottle-feed versus mother-feed children – Long term effects of infant feeding on congnitive development and school performance","authors":"F. Shah, Fasiha Shah, Shaista Ehsan, Nabia Shah","doi":"10.38106/lmrj.2023.5.1.03","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.03","url":null,"abstract":"Mother feed (i.e. Breast feeding) provides essential nutrients, antibodies and immune cells to allow infant growth and protect them from infections. Mother feed not only have short term effects but it influences brain development as well as life time effects in many organ systems. This study was conducted to compare mother feed and bottle feed children at school going age. The self-administrated questionnaire survey was conducted including parents of children between 5 to 10 years of age (n=300). There was no significant difference found in the median age of children reported for, neither there was any significant difference in the weight of the two groups. However, bottle feed children significantly showed better performance in mathematics while mother feed children were significantly better in general science and physical activities at school. The study concluded that bottle feed or breast feed both provides nutrition and overall children were doing good.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125033299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-27DOI: 10.38106/lmrj.2023.5.1.04
H. Khattak, Hafsah Arshad, K. Anwar
This study was a randomized controlled trial conducted at Noor Hospital Rawalpindi, Pakistan to compare muscle energy technique (MET) and conventional physiotherapy techniques in patients with confirmed diagnosis of adhesive capsulitis. This study was, conducted between March 2021 to August 2021. A total of 30 participants regardless of gender, aged between 30 to 60 years, with confirmed diagnosis of idiopathic adhesive capsulitis were included. Participants with unstable shoulder fractures and dislocation, thoracic outlet syndrome, rotator cuff injuries, reflex sympathetic syndrome, rheumatoid arthritis, extreme shoulder pain not relieved by any medication or rest were excluded from study. The patients were assigned in experimental (n=15) and control group (n=15) using sealed envelope method. Participants in both groups were assessed at baseline and after 4 weeks. The outcome of the treatment was measured in terms of numeric pain rating scale (NPRS), Shoulder Pain & Disability Index (SPADI) and goniometer for measuring shoulder ROM. The overall mean age of participants was 51.64±5.31 years. The study included 12 (40%) males and 18 (60%) females. After 4 weeks of treatment a significant difference (p-value <0.05) was seen between groups in terms of pain, disability and shoulder ROM. The study concluded that MET is a non-invasive treatment for reducing pain. The MET was also shown to improve functional ability and ROM in patients with adhesive capsulitis in comparison to conventional physical therapy treatment.
{"title":"Comparing muscle energy technique (MET) versus conventional physiotherapy in cases of adhesive capsulitis of shoulder- A randomized controlled trial","authors":"H. Khattak, Hafsah Arshad, K. Anwar","doi":"10.38106/lmrj.2023.5.1.04","DOIUrl":"https://doi.org/10.38106/lmrj.2023.5.1.04","url":null,"abstract":"This study was a randomized controlled trial conducted at Noor Hospital Rawalpindi, Pakistan to compare muscle energy technique (MET) and conventional physiotherapy techniques in patients with confirmed diagnosis of adhesive capsulitis. This study was, conducted between March 2021 to August 2021. A total of 30 participants regardless of gender, aged between 30 to 60 years, with confirmed diagnosis of idiopathic adhesive capsulitis were included. Participants with unstable shoulder fractures and dislocation, thoracic outlet syndrome, rotator cuff injuries, reflex sympathetic syndrome, rheumatoid arthritis, extreme shoulder pain not relieved by any medication or rest were excluded from study. The patients were assigned in experimental (n=15) and control group (n=15) using sealed envelope method. Participants in both groups were assessed at baseline and after 4 weeks. The outcome of the treatment was measured in terms of numeric pain rating scale (NPRS), Shoulder Pain & Disability Index (SPADI) and goniometer for measuring shoulder ROM. The overall mean age of participants was 51.64±5.31 years. The study included 12 (40%) males and 18 (60%) females. After 4 weeks of treatment a significant difference (p-value <0.05) was seen between groups in terms of pain, disability and shoulder ROM. The study concluded that MET is a non-invasive treatment for reducing pain. The MET was also shown to improve functional ability and ROM in patients with adhesive capsulitis in comparison to conventional physical therapy treatment.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121817894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-12DOI: 10.38106/lmrj.2022.4.4-01
S. Abid
Antioxidants are showing assoiation with development and progression of malignancy.
抗氧化剂显示与恶性肿瘤的发生和发展有关。
{"title":"ANTI-OXIDANTS AND LUNG CANCER","authors":"S. Abid","doi":"10.38106/lmrj.2022.4.4-01","DOIUrl":"https://doi.org/10.38106/lmrj.2022.4.4-01","url":null,"abstract":"Antioxidants are showing assoiation with development and progression of malignancy. ","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133140600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-12DOI: 10.38106/lmrj.2022.4.4-08
Marvi Shaikh, N. Channa, Sadia Qamar Arain, Ghulam mujtaba Junejo, A. Shahani, Mehnaz Shaikh
Corona Virus (COVID)- 19 is a pathogenic viral infection that presents as a new worldwide public health crisis. This review article aims at recapitulating waves of COVID-19, vaccination programs, treatment options, and the current scenario of COVID-19 in Pakistan. All available literature on PubMed, Scopus databases and science direct and Google scholar relating to COVID-19 published between 2019 to January 2022 was reviewed. The first wave of COVID-19 presented as severe acute respiratory syndrome. The second wave had a modest intensity, affecting only Sindh's southern province, and peaked in mid-December 2020. The third wave, which primarily disturbed the regions of Khyber Pakhtunkhwa and Punjab, peaked in the late April 2021, when a new strain of SARS-CoV-2 was discovered in over 64 countries, including Pakistan, as of January 27, 2021. Fourth wave qualifying measures was forced in May, after which cases balanced out and most of the mortality was reported in Punjab, followed by Sindh. The 5th wave with a positive ratio in Karachi had the increasing trend from 2% to 6%. In clinical trials, treatment with a combination of Azithromycin and Chloroquine shown efficacy against COVID-19. The Tocilizumab was used to treat COVID-19–related symptoms. Vaccination appeared to be vital to control the COVID-19 disease outbreak with seven licensed vaccines. Currently 72% Pakistani population is either vaccinated or have been infected at least once.
{"title":"IT’S ALL ABOUT COVID-19: A REVIEW OF PATTERN OF WAVES IN PAKISTAN, DRUGS AND VACCINATION PROGRAMS","authors":"Marvi Shaikh, N. Channa, Sadia Qamar Arain, Ghulam mujtaba Junejo, A. Shahani, Mehnaz Shaikh","doi":"10.38106/lmrj.2022.4.4-08","DOIUrl":"https://doi.org/10.38106/lmrj.2022.4.4-08","url":null,"abstract":"Corona Virus (COVID)- 19 is a pathogenic viral infection that presents as a new worldwide public health crisis. This review article aims at recapitulating waves of COVID-19, vaccination programs, treatment options, and the current scenario of COVID-19 in Pakistan. All available literature on PubMed, Scopus databases and science direct and Google scholar relating to COVID-19 published between 2019 to January 2022 was reviewed. The first wave of COVID-19 presented as severe acute respiratory syndrome. The second wave had a modest intensity, affecting only Sindh's southern province, and peaked in mid-December 2020. The third wave, which primarily disturbed the regions of Khyber Pakhtunkhwa and Punjab, peaked in the late April 2021, when a new strain of SARS-CoV-2 was discovered in over 64 countries, including Pakistan, as of January 27, 2021. Fourth wave qualifying measures was forced in May, after which cases balanced out and most of the mortality was reported in Punjab, followed by Sindh. The 5th wave with a positive ratio in Karachi had the increasing trend from 2% to 6%. In clinical trials, treatment with a combination of Azithromycin and Chloroquine shown efficacy against COVID-19. The Tocilizumab was used to treat COVID-19–related symptoms. Vaccination appeared to be vital to control the COVID-19 disease outbreak with seven licensed vaccines. Currently 72% Pakistani population is either vaccinated or have been infected at least once.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126657769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lumber Puncture (LP) can be performed for both diagnostic and therapeutic purposes. Failure to perform LP is associated with greater morbidity and mortality due to delayed diagnosis and improper management. This study was conducted to evaluate frequency of LP refusal and its associated factors among parents of children hospitalized with suspected Central Nervous System (CNS) infections. This cross-sectional study was conducted from October 2021 to April 2022 at National Institute of Child Health (NICH), Karachi, Pakistani. Parents/attendants of all pediatric patients hospitalized with suspected CNS infections and advised LP by the treating physicians were included in the study. A semi-structured questionnaire was used to assess the perception and attitude of patients’ towards the procedure and if they agreed for their child to undergo LP. Parents of 338 children were enrolled, out of which 203(60.1%) consented for LP. Majority refused because of fear of complications followed by those who believed LP was not required (29%). Common misconceptions regarding LP complications were risk of death (13%), epilepsy (11%) and paralysis (7%). Significantly lower refusals were observed when no other course was offered as alternate to LP (p-value <0.001). There was high frequency of LP refusal among parents of pediatric patients presenting with suspected CNS infections, most important cause of refusal was fear of complications.
{"title":"LUMBER PUNCTURE AND ASSOCIATED FACTORS AMONG PARENTS OF CHILDREN HOSPITALIZED WITH SUSPECTED CENTRAL NERVOUS SYSTEM INFECTONS","authors":"Shahzadi Dilawar Hussain, Misbah Anjum, Safia Bibi, Shazia Soomro, Shazia Lashari, Bilquis Naeem","doi":"10.38106/lmrj.2022.4.4-07","DOIUrl":"https://doi.org/10.38106/lmrj.2022.4.4-07","url":null,"abstract":" \u0000Lumber Puncture (LP) can be performed for both diagnostic and therapeutic purposes. Failure to perform LP is associated with greater morbidity and mortality due to delayed diagnosis and improper management. This study was conducted to evaluate frequency of LP refusal and its associated factors among parents of children hospitalized with suspected Central Nervous System (CNS) infections. This cross-sectional study was conducted from October 2021 to April 2022 at National Institute of Child Health (NICH), Karachi, Pakistani. Parents/attendants of all pediatric patients hospitalized with suspected CNS infections and advised LP by the treating physicians were included in the study. A semi-structured questionnaire was used to assess the perception and attitude of patients’ towards the procedure and if they agreed for their child to undergo LP. Parents of 338 children were enrolled, out of which 203(60.1%) consented for LP. Majority refused because of fear of complications followed by those who believed LP was not required (29%). Common misconceptions regarding LP complications were risk of death (13%), epilepsy (11%) and paralysis (7%). Significantly lower refusals were observed when no other course was offered as alternate to LP (p-value <0.001). There was high frequency of LP refusal among parents of pediatric patients presenting with suspected CNS infections, most important cause of refusal was fear of complications.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"158 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126756581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Venous thromboembolism (VTE) was once considered a rare finding in pediatric population but it has been increasing with recent advances in medical care and technology to diagnose it. This study was conducted to determine the clinical presentation, associated factors and outcome of VTE in hospitalized children in a tertiary care children hospital of Karachi. This descriptive cross sectional study was conducted at National Institute of Child Health, Karachi from December 2020 to January 2022. All patients hospitalized with VTE or who were diagnosed to have DVT while at hospital were included in study. Demographic characteristics, clinical presentation, medical history and laboratory workup was recorded in a semi-structured proforma. Patients were managed by treating physicians as per hospital protocol. Treatment details were recorded along with outcome. A Total of 36 children were diagnosed with VTE. Nine (25%) patients were admitted with clinical features suggestive of DVT while remaining 27 (75%) developed DVT during hospital stay. Median hospital stay of those who developed DVT at hospital was 15 days (IQR 10-30days). Infectious etiology (n=21, 58.3%) was the most common admitting diagnosis followed by central nervous system disorders (n=4, 11.1%). Common clinical features among VTE children were fever, seizures and edema of limbs. Prolonged hospital stay with immobilization and central venous catheterization particularly due to infectious etiology are common factors among children who develop VTE and such patients need to be considered for VTE prophylaxis and treatment.
{"title":"VENOUS THROMBOEMBOLISM AND ITS OUTCOME IN PEDIATRIC PATIENTS AT A TER-TIARY CARE HOSPITAL OF KARACHI","authors":"Rimsha Shahid, Misbah Anjum, Safia Bibi, Shazia Soomro, Hifza Aiman, Shahzadi Dilawar","doi":"10.38106/lmrj.2022.4.4-06","DOIUrl":"https://doi.org/10.38106/lmrj.2022.4.4-06","url":null,"abstract":"Venous thromboembolism (VTE) was once considered a rare finding in pediatric population but it has been increasing with recent advances in medical care and technology to diagnose it. This study was conducted to determine the clinical presentation, associated factors and outcome of VTE in hospitalized children in a tertiary care children hospital of Karachi. This descriptive cross sectional study was conducted at National Institute of Child Health, Karachi from December 2020 to January 2022. All patients hospitalized with VTE or who were diagnosed to have DVT while at hospital were included in study. Demographic characteristics, clinical presentation, medical history and laboratory workup was recorded in a semi-structured proforma. Patients were managed by treating physicians as per hospital protocol. Treatment details were recorded along with outcome. A Total of 36 children were diagnosed with VTE. Nine (25%) patients were admitted with clinical features suggestive of DVT while remaining 27 (75%) developed DVT during hospital stay. Median hospital stay of those who developed DVT at hospital was 15 days (IQR 10-30days). Infectious etiology (n=21, 58.3%) was the most common admitting diagnosis followed by central nervous system disorders (n=4, 11.1%). Common clinical features among VTE children were fever, seizures and edema of limbs. Prolonged hospital stay with immobilization and central venous catheterization particularly due to infectious etiology are common factors among children who develop VTE and such patients need to be considered for VTE prophylaxis and treatment.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121821736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-12DOI: 10.38106/lmrj.2022.4.4-04
H. Memon, A. A. Memon, Abdul Qadir Ansari, A. Otho
Skin infections due to microbes are reported with high spread and reportedly affected one –third of the world population. Connective tissue cells produce collagen and connective tissue fibers to heal wounds of skin and white blood cells produce antibodies to fight against harmful microbes. This study presents the process of synthesis of nanofiberous dressing loaded with Aloe vera and tea tree oil. Aloe Vera and Tea tree oil contain glucomannan and terpinin-4-ol, which help in the production of collagen and kill microbes. The surface morphology of prepared dressing was studied using Scanning Electron Microscope micrographs. The average diameter of nanofibers was measured to be 137.32nm. Fourier transform infrared spectroscopy of nanofiberous dressing confirmed the loading of aloe vera and tea tree oil. Drug release profile was analyzed by UV-vis spectroscopy. It was observed that 100% drug released within 12 minutes. The antimicrobial properties of prepared fibers against Aspergillus Niger (fungi) and Escherichia coli (bacteria) were systematically evaluated. The results showed that aloe vera- tea tree oil composite fibrous dressing was found to be effective for antimicrobial activity.
{"title":"FABRICATION AND CHARACTERIZATION OF ALOE VERA AND TEA TREE OIL LOADED ANTIMICROBIAL NANOFIBEROUS DRESSING","authors":"H. Memon, A. A. Memon, Abdul Qadir Ansari, A. Otho","doi":"10.38106/lmrj.2022.4.4-04","DOIUrl":"https://doi.org/10.38106/lmrj.2022.4.4-04","url":null,"abstract":"Skin infections due to microbes are reported with high spread and reportedly affected one –third of the world population. Connective tissue cells produce collagen and connective tissue fibers to heal wounds of skin and white blood cells produce antibodies to fight against harmful microbes. This study presents the process of synthesis of nanofiberous dressing loaded with Aloe vera and tea tree oil. Aloe Vera and Tea tree oil contain glucomannan and terpinin-4-ol, which help in the production of collagen and kill microbes. The surface morphology of prepared dressing was studied using Scanning Electron Microscope micrographs. The average diameter of nanofibers was measured to be 137.32nm. Fourier transform infrared spectroscopy of nanofiberous dressing confirmed the loading of aloe vera and tea tree oil. Drug release profile was analyzed by UV-vis spectroscopy. It was observed that 100% drug released within 12 minutes. The antimicrobial properties of prepared fibers against Aspergillus Niger (fungi) and Escherichia coli (bacteria) were systematically evaluated. The results showed that aloe vera- tea tree oil composite fibrous dressing was found to be effective for antimicrobial activity.","PeriodicalId":184438,"journal":{"name":"LIAQUAT MEDICAL RESEARCH JOURNAL","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125499723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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