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Rise in mobile gadgets use for school learning and health issues of children- Long-term sequelae of covid-19 pandemic 用于学校学习和儿童健康问题的移动设备使用量上升——covid-19大流行的长期后遗症
Pub Date : 2022-09-30 DOI: 10.38106/lmrj.2022.4.3-06
Nabia Shah, Ahmed Muhammad Shaikh, Fasiha Shah
COVID-19 pandemic has brought a paradigm shift in education with a trend of online learning and even schooling. During complete lockdown period schools were shifted to smartphones and computers. This study aimed to explore the pattern of smartphone use before and after the COVID-19 pandemic and the health issues of school-going children in post-COVID-19 period. There was a significant rise in the timings of mobile phone use from 2 hours to 7 hours per day. A total of 90% of student’s mothers reported behavioral change where lack of socializing was the most commonly reported change. Irritation of eyes and dryness were the most commonly reported ocular disorders.  The rise of mobile phones has brought several behavioral and ocular disorders due to long hours of use. There is a need to confirm health-related issues of smartphone use in large prospective studies and develop preventive strategies.
新冠肺炎疫情带来了教育模式的转变,在线学习甚至学校教育成为趋势。在全面封锁期间,学校转而使用智能手机和电脑。本研究旨在探讨COVID-19大流行前后的智能手机使用模式以及后COVID-19时期学龄儿童的健康问题。每天使用手机的时间从2小时显著增加到7小时。共有90%的学生母亲报告了行为上的改变,其中缺乏社交是最常见的变化。眼睛刺激和干燥是最常见的眼部疾病。由于长时间使用手机,手机的兴起带来了一些行为和眼部疾病。有必要在大型前瞻性研究中确认智能手机使用与健康相关的问题,并制定预防策略。
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引用次数: 0
Assessment of macular function in dense cataract using Maddox rod 用Maddox棒评价致密性白内障的黄斑功能
Pub Date : 2022-06-29 DOI: 10.38106/lmrj.2022.4.2-05
M. A. Memon, Ayesha Kazmi, Mehak Nazeer, Abdul Hameed Talpur, Muhammad Munawar, Humudullah
Cataract is a leading cause of blindness worldwide. However there is surgical option available for treatment with complete cure in majority of patients. For dense cataract Maddox Rod was evaluated. A total of 200 patients were recruited. Maddox Rod test for macular function appears to be useful in a great majority of patients. The assessment of macular function in dense cataract is difficult but the Psycho physiological test like Maddox rod test was found to be the reliable in patients with cataract and its quick and understandable
白内障是全世界失明的主要原因。然而,大多数患者可选择手术治疗并完全治愈。对致密性白内障行马多克斯棒检查。总共招募了200名患者。马多克斯棒试验黄斑功能似乎是有用的,在绝大多数患者。致密性白内障患者黄斑功能的评估比较困难,而心理生理试验如Maddox棒试验是一种可靠且快速易懂的方法
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引用次数: 0
Analysis of pattern of ABO Blood groups in pediatric diabetic patients – An observational study 小儿糖尿病患者ABO血型模式分析-一项观察性研究
Pub Date : 2022-06-29 DOI: 10.38106/lmrj.2022.4.2-06
N. Javed, Shazia Yasin, Javeria Fatima, T. Khan, Tooba Fateen, Nazish Saqlain, Saima Farhan
Diabetes Mellitus (DM) is the most frequently occurring metabolic disorder, caused by inadequacy in secretion of insulin or malfunction leading to chronic hyperglycemia.  Well-established corroborations have been reported in the literature suggesting association of ABO blood group with DM. The available literature focuses on adult population, with limited information of said association in children. Thus this study was aimed to determine the association of ABO blood group with Diabetes in pediatric patients having confirmed diagnosis. This was a comparative cross sectional study conducted from October 2021-January 2022 at Endocrinology Ward, Children Hospital Lahore (CHL), Pakistan. The study was approved by the local research ethics committee of CHL and conducted according to the declaration of Helsinki 2000. Blood grouping was done by forward and reverse methods. A total of 25 patients, including 18 males and 7 females were included. Frequency of blood group B (n=10;40%) was highest followed by blood group O (n=4;16%), A blood group (n=3;12%), and AB (n=1;4%) in males. In females, the blood group AB (n=3;12%) has the highest frequency followed by O (n=2;8%). Blood group A (n=1;4%) and B (n=1;4%) had the  same frequency among female diabetic patients
糖尿病(DM)是最常见的代谢紊乱,由胰岛素分泌不足或功能障碍导致慢性高血糖引起。已有文献证实ABO血型与糖尿病相关。现有文献主要集中在成人人群,关于儿童的相关信息有限。因此,本研究旨在确定ABO血型与确诊的儿科糖尿病患者的关系。这是一项比较横断面研究,于2021年10月至2022年1月在巴基斯坦拉合尔儿童医院(CHL)内分泌科病房进行。本研究经CHL当地研究伦理委员会批准,并根据2000年赫尔辛基宣言进行。采用正反两种方法进行血型分型。共纳入25例患者,其中男性18例,女性7例。男性中B型血(n=10, 40%)发病率最高,其次为O型血(n=4, 16%)、A型血(n=3, 12%)、AB型血(n=1, 4%)。在女性中,AB血型(n=3;12%)的发病率最高,其次是O血型(n=2;8%)。女性糖尿病患者中A型血(n=1;4%)与B型血(n=1;4%)发生率相同
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引用次数: 0
Hyperprolectinemia in newlyHyperprolectinemia in newly diagnosed Breast cancer in younger (<50) women diagnosed Breast cancer in younger (<50) women 新诊断乳腺癌的年轻(<50)女性高泌乳素血症
Pub Date : 2022-06-29 DOI: 10.38106/lmrj.2022.4.2-02
J. N. Qureshi, K. A. Talpur
Breast cancer is a common malignancy among women. There are a number of established risk factors for breast cancer in younger population. Hyperprolactinemia is observed to be higher in breast cancer patients. However its presentation in younger (<50 years) women is not well understood. This study was conducted to describe serum prolactin level in newly diagnosed breast cancer patients presented with nipple discharge without any apparent other cause of hyperprolactinemia. The results showed high serum prolactin levels in all these patients. There was no significant correlation observed between serum prolactin and the age of the patients.It was concluded that breast cancer patients presenting with nipple discharge show varying degree of hyperprolactinemia. It requires further studies to explore if it has a causal relationship or it is a feature of breast cancer.
乳腺癌是妇女中常见的恶性肿瘤。在年轻人群中有许多确定的乳腺癌风险因素。据观察,乳腺癌患者的高泌乳素血症更高。然而,其在年轻(<50岁)女性中的表现尚不清楚。本研究描述了新诊断的乳腺癌患者的血清催乳素水平乳头溢液没有任何明显的其他原因引起的高催乳素血症。结果显示,所有患者血清催乳素水平均较高。血清催乳素水平与患者年龄无显著相关性。结论以乳头溢液为表现的乳腺癌患者表现出不同程度的高泌乳素血症。这需要进一步的研究来探索它是否有因果关系,或者它是乳腺癌的一个特征。
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引用次数: 0
Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase 急性白血病的止血和血栓参数-缓解诱导期前后的比较
Pub Date : 2022-06-29 DOI: 10.38106/lmrj.2022.4.2-03
T. Khan, T. Masood, Z. Bashir, T. Farzana, A. Sattar, T. Shamsi
This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). A total of 110 diagnosed acute leukemia patients and 40 normal individuals were enrolled in the study. Questionnaire were filled and patients’ blood specimens were collected before the commencement and post induction chemotherapy. Prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor antigen (vWF Ag), fibrinogen level, factor VIIIc (FVIIIc), D-Dimers, fibrinogen degradation products (FDPs), anti-thrombin III (AT), lupus anticoagulant (LA), protein C (PC), protein S and diluted russel viper venom test (DRVVT) were conducted in all the participants. A significant rise was identified in post-induction levels of PT, aPTT, vWF Ag, fibrinogen and factor VIII in acute leukemia patients. Analysis of fibrinolytic markers indicated increased D-Dimers and plasminogen levels while the levels of alpha 2 anti-plasmin were reduced in pretreated patients. Thrombotic markers’ assessment showed increased levels of AT and LA while decreased level of PC in pretreated acute leukemia patients. It was concluded that remission induction chemotherapy, in acute leukemia patients, significantly affects the coagulation, fibrinolytic and thrombotic parameters.
本研究旨在比较急性髓性白血病(AML)和急性淋巴性白血病(ALL)诱导化疗前后的止血、纤溶和血栓参数。共有110名确诊的急性白血病患者和40名正常人参加了这项研究。在化疗开始前和诱导化疗后分别填写问卷和采集患者血样。对所有受试者进行凝血酶原时间(PT)、活化部分凝血活素时间(aPTT)、血管性血友病因子抗原(vWF Ag)、纤维蛋白原水平、viii因子(fviii)、d -二聚体、纤维蛋白原降解产物(FDPs)、抗凝血酶III (AT)、狼疮抗凝剂(LA)、蛋白C (PC)、蛋白S和稀释russel蝰蛇毒液试验(DRVVT)。急性白血病患者诱导后PT、aPTT、vWF Ag、纤维蛋白原和因子VIII水平显著升高。纤维蛋白溶解标志物分析显示,治疗前患者的d -二聚体和纤溶酶原水平升高,而α 2抗纤溶酶水平降低。血栓标志物评估显示,在治疗前的急性白血病患者中,AT和LA水平升高,而PC水平降低。结论缓解诱导化疗对急性白血病患者凝血、纤溶及血栓参数有显著影响。
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引用次数: 0
Global disparity in breast cancer screening guidelines- Is there a need for an individualized approach for breast cancer screening? 乳腺癌筛查指南的全球差异——是否需要个体化的乳腺癌筛查方法?
Pub Date : 2022-04-01 DOI: 10.38106/lmrj.2022.4.1-01
Almas Qazi
Breast cancer screening is the key to better clinical outcomes. Cancer diagnosed at the stage where it is still within the ducts has the highest potential for best survival. A screening mammogram is a key for early detection. However, there is variation in the age guidelines for starting the screening and cessation. Given the rate of breast cancer in the region, the government's economic resources and the priority of the screening service all play a role. Developed countries have benefited from screening mammogram facilities and improved disease outcomes, but underdeveloped countries have not yet developed national screening programs. Thus nations must take the incidence of the biology of breast cancer into account and make evidence-based
乳腺癌筛查是获得更好临床结果的关键。在肿瘤仍在导管内的阶段诊断出的癌症生存率最高。乳房x光检查是早期发现的关键。然而,在开始筛查和停止筛查的年龄指南上存在差异。考虑到该地区的乳腺癌发病率,政府的经济资源和筛查服务的优先级都发挥了作用。发达国家已经从乳房x光检查设备和改善的疾病结果中受益,但不发达国家尚未制定国家筛查计划。因此,各国必须考虑到乳腺癌的生物学发生率,并以证据为基础
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引用次数: 0
COVID-19 and humoral immune response in convalescent plasma donors in Pakistani cohort. 巴基斯坦队列恢复期血浆供者的COVID-19与体液免疫反应
Pub Date : 2022-04-01 DOI: 10.38106/lmrj.2022.4.1-02
J. Hassan, Shahtaj Masood, N. Fatima, T. Khan, J. Akram, Faridoon Ahmad, Lubna Meraj, Ayesha Mahesar, Z. Malik, N. Sheikh, Irfan Ghafoor baig, M. Adil, Muhammad Asif, S. Maqsood, Mahjabeen Imam, Durenaz Jamal, Dilnasheen Safdar, T. Shamsi
Current COVID-19 pandemic has affected the entire globe. While there was no vaccine neither any specific treatment, investigational use of convalescent plasma has been explored in clinical trials. A prospective multicenter study of convalescent plasma was conducted. Donors were tested for total Anti-SARS-CoV-2 antibodies by electrochemiluminescence (ECLIA) and RT-PCR for COVID-19. Enzyme Linked Immunosorbent Assay (ELISA) was used to detect semi-quantitative and quantitative IgG anti-SARS-COV-2 antibodies. IgG Immunofluorescence-based lateral flow immunoassay (LFIA) was used to recheck seronegative donors. A total of 400 donors were enrolled. Twelve donors were SARS-CoV-2 positive by RT-PCR. Nine of 12 donors had developed SARS-CoV-2 IgG antibodies, while in 3 donors antibodies were not developed. A total of 70 donors (17.5%) were deferred due to seronegative status; 64 (16%) of them did not develop antibodies when plasma collection was planned. The IgG semiquantitative ELISA was positive in 282 and quantitative in 284 of 330 donors with a mean value of >1:160 and 44.10±39.22 IU/ml respectively. A total of 116 (29%) donors did not show IgG humoral response to COVID-19 even 28 days from the onset of illness. Subsequently, LFIA method was able to detect IgG antibodies in 20 of 48 (41.6%) seronegative donors and in 20 of 34 (58.8%) ECLIA positive ELISA negative donors. Viral RNA detection in recovered asymptomatic patients with concomitant IgG antibodies indicates recovery. Inability to detect antibodies by different testing kits may be due to their different antigenic targets or sensitivity. Significance of a positive COVID-19 RT-PCR in asymptomatic recovered patients is yet to be determined.
当前,新冠肺炎疫情波及全球。虽然没有疫苗,也没有任何特定的治疗方法,但已经在临床试验中探索了恢复期血浆的研究性使用。对恢复期血浆进行了前瞻性多中心研究。通过电化学发光(ECLIA)和RT-PCR检测供体的COVID-19总抗sars - cov -2抗体。采用酶联免疫吸附试验(ELISA)检测半定量和定量IgG抗sars - cov -2抗体。IgG免疫荧光侧流免疫分析法(LFIA)用于复检血清阴性供者。总共登记了400名捐赠者。12名供体经RT-PCR检测为SARS-CoV-2阳性。12名献血者中有9人产生了SARS-CoV-2 IgG抗体,3名献血者没有产生抗体。共有70名献血者(17.5%)因血清状态阴性而被推迟;其中64例(16%)在计划收集血浆时未产生抗体。330例献血者中IgG半定量ELISA阳性282例,定量284例,平均值分别为>∶160和44.10±39.22 IU/ml。116名(29%)献血者在发病后28天内未表现出对COVID-19的IgG体液反应。随后,LFIA方法能够在48例血清阴性供者中的20例(41.6%)和34例ECLIA阳性ELISA阴性供者中的20例(58.8%)中检测到IgG抗体。在无症状的康复患者中检测病毒RNA并伴有IgG抗体提示康复。不同的检测试剂盒无法检测抗体可能是由于它们不同的抗原靶点或敏感性。COVID-19 RT-PCR在无症状康复患者中的阳性意义尚未确定。
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引用次数: 0
Artificial Intelligence in Aid Efficient Mental Healthcare in context of State-of-the -art Sir Cowasjee Mental Health Institute at Hyderabad Sindh Pakistan 在巴基斯坦信德省海得拉巴最先进的Sir Cowasjee精神卫生研究所的背景下,人工智能帮助有效的精神卫生保健
Pub Date : 2022-04-01 DOI: 10.38106/lmrj.2022.4.1-09
Aijaz Patoli, Shehram Syed, Abbas Syed, Zafi Sherhan Syed
Artificial intelligence (AI), often described, as the machine simulation of human intelligence, is a branch of computer science that solves problems automatically using computational algorithms. AI systems work by first consuming massive volumes of labeled training data, analyzing it for patterns, and finally using these patterns to make predictions. On the other hand mental health issues are increasing in human thus use AI in provision of mental health aid would be a novel approach.
人工智能(AI),通常被描述为人类智能的机器模拟,是计算机科学的一个分支,它使用计算算法自动解决问题。人工智能系统的工作原理是首先消耗大量标记的训练数据,分析其模式,最后使用这些模式进行预测。另一方面,人类的心理健康问题越来越多,因此使用人工智能提供心理健康援助将是一种新颖的方法。
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引用次数: 0
Frequency of different Indications and findings for colonoscopy in a Tertiary Care Hospital 三级医院结肠镜检查的不同适应症和结果的频率
Pub Date : 2022-04-01 DOI: 10.38106/lmrj.2022.4.1-08
Jalpa Devi, N. Seerani, Amerta Bai, Rabia Farooque, Hira Laghari, Riaz Hussain Awan, Akram Bajwa, Komal Kumari, Seema Nayab
Colonoscopy is one of the most important diagnostic tools to assess the structural abnormalities of the large intestine and distal ileum. To date, there is a paucity of data in Pakistan on indications and findings of colonoscopy. Therefore, our study aimed to evaluate the indications and endoscopic findings of patients who underwent colonoscopy at a tertiary care hospital in interior Sindh, Pakistan. This prospective cross-sectional study of 125 patients who underwent lower gastrointestinal endoscopy was conducted in the Endoscopy Unit of LUMHS Civil Hospital Hyderabad / Jamshoro from April 2020 to September 2020. To be eligible participants had to be 14 years or older, of either gender and giving informed consent. Data regarding demographic characteristics, indications, and endoscopic findings were gathered on a pre-designed proforma.A total of 125 participants were recruited with a mean age of 39 ± 20, out of which 60% were males. Rectal bleeding was the most common indication (70.4%) followed by abdominal pain (9.6%), chronic diarrhea (8%), altered bowel habits (6.4%), constipation (2.4%), post-cancer surveillance (1.6%), weight loss, and anemia (0.8%) each.  The most common colonoscopy findings were hemorrhoids (29.6%),and suspected tumor/growth (14.4%), while 22.4% were normal. The most common indication in our study was per rectal bleeding with hemorrhoids as the most common endoscopic finding on colonoscopy.
结肠镜检查是评估大肠和远端回肠结构异常最重要的诊断工具之一。迄今为止,巴基斯坦缺乏关于结肠镜检查的适应症和结果的数据。因此,我们的研究旨在评估在巴基斯坦信德省内陆一家三级医院接受结肠镜检查的患者的适应症和内窥镜检查结果。这项前瞻性横断面研究于2020年4月至2020年9月在Hyderabad / Jamshoro LUMHS民用医院内窥镜科对125名接受下胃肠道内窥镜检查的患者进行。符合条件的参与者必须年满14岁,不分性别,并给予知情同意。有关人口统计学特征、适应症和内窥镜检查结果的数据收集在预先设计的表格上。共招募125名参与者,平均年龄39±20岁,其中60%为男性。直肠出血是最常见的适应症(70.4%),其次是腹痛(9.6%)、慢性腹泻(8%)、排便习惯改变(6.4%)、便秘(2.4%)、癌症后监测(1.6%)、体重减轻和贫血(0.8%)。最常见的结肠镜检查结果是痔疮(29.6%),疑似肿瘤/生长(14.4%),而22.4%是正常的。在我们的研究中,最常见的适应症是直肠出血合并痔疮,这是结肠镜检查中最常见的内窥镜发现。
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引用次数: 0
Awareness of mothers regarding use of natural probiotics in school going healthy children's diet 提高母亲在学校使用天然益生菌的意识,促进儿童健康饮食
Pub Date : 2022-04-01 DOI: 10.38106/lmrj.2022.4.1-07
F. Shah, Nabia Shah, Faisal Shah
Probiotics are recently getting popular as immunity enhancers, and being investigated to treat acute infections, including gastroenteritis. Commonly used probiotics have been in practice for ancient periods. This study was thus conducted to evaluate the knowledge of mothers of school-going children regarding the use of probiotics in their children's diet. Our results showed that 23% of women were aware of probiotics and their health benefits out of 200 women surveyed, while 16% had never heard of probiotics. However great majority were taking probiotic-rich food, including yogurt, buttermilk, and cheese, in their diet. The knowledge of the use of probiotics in mothers was significantly associated with mothers' level of education. We conclude that there is limited knowledge of probiotics and their health benefits in mothers, but given the anecdotal evidence and inherited dietary patterns, probiotics are part of the daily diet of the school-going children in our study population.  
最近,益生菌作为免疫增强剂越来越受欢迎,并被研究用于治疗急性感染,包括肠胃炎。常用的益生菌在古代就有实践。因此,进行这项研究是为了评估学龄儿童的母亲对在其孩子的饮食中使用益生菌的知识。我们的研究结果显示,在接受调查的200名女性中,23%的女性知道益生菌及其对健康的好处,而16%的女性从未听说过益生菌。然而,绝大多数人在饮食中摄入富含益生菌的食物,包括酸奶、酪乳和奶酪。母亲对益生菌使用的了解程度与母亲的受教育程度显著相关。我们得出的结论是,对益生菌及其对母亲健康的益处的了解有限,但鉴于坊间证据和遗传的饮食模式,益生菌是我们研究人群中学龄儿童日常饮食的一部分。
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引用次数: 0
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LIAQUAT MEDICAL RESEARCH JOURNAL
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