首页 > 最新文献

Sumatera Medical Journal最新文献

英文 中文
ASSOCIATION BETWEEN SERUM ALP LEVELS AND PRE-OPERATIVE LDH TOWARDS CLINICAL PROGNOSIS OF OSTEOSARCOMA PATIENTS IN H. ADAM MALIK HOSPITAL, MEDAN 血清alp水平与术前LDH对骨肉瘤患者临床预后的关系
Pub Date : 2023-03-02 DOI: 10.32734/sumej.v6i1.8991
Gerhard Christoffel Tampubolon, Otman Siregar, Andriandi
Background: The prognosis of osteosarcoma is very unsatisfactory due to frequent tumor metastases to the lung or resistance to chemotherapy. A marker is needed to identify the prognosis of patients with osteosarcoma when diagnosed with the aim of being able to receive cancer treatment as soon as possible to improve a better prognosis. Alkaline phosphatase (ALP) and Lactate dehydrogenase (LDH) have potential in assessing the prognosis in osteosarcoma. Purpose and Objectives: The researcher wanted to investigate the relationship between preoperative serum ALP and LDH levels on the clinical prognosis of osteosarcoma patients. Methods: This research is analytic retrospective with the source of data is medical records and was conducted at the Department of Surgery FK-USU/RSUP Haji Adam Malik Medan with research code of ethics No. 426/KEPK/USU/2022. The subjects of this study were patients with osteosarcoma who were treated at Division of Orthopedic Surgery at Haji Adam Malik Hospital Medan from January 2015-December 2017 who met the inclusion criteria. Results: There was no significant relationship between ALP and LDH with five-year survival with p-values ​​of 0.557 and 0.179 (p>0.05). ALP has a weak correlation with five-year survival with an r value of -0.019 which means the higher the ALP, the lower the five-year survival of the patient. Meanwhile, LDH has a weak correlation with an r value of 0.093, which means the higher the LDH, the higher the patient's five-year survival. The ALP value in this study had a median value of 212 U/L and an LDH value of 489 U/L. ALP has sensitivity of 61.1% and specificity of 57.1% with a cut-off of 217.5 U/L. Meanwhile, LDH sensitivity was 61.2% and specificity was 51.4% with a cut-off of 488.5 U/L. Conclusion: There is no significant relationship between ALP and LDH with five-year survival.
背景:骨肉瘤的预后非常不理想,因为肿瘤经常转移到肺部或对化疗有耐药性。骨肉瘤患者在确诊时需要一个标志物来识别其预后,以便尽早接受癌症治疗,改善预后。碱性磷酸酶(ALP)和乳酸脱氢酶(LDH)在评估骨肉瘤的预后方面具有潜在的价值。目的:探讨术前血清ALP和LDH水平与骨肉瘤患者临床预后的关系。方法:本研究采用回顾性分析方法,数据来源为医疗记录,在FK-USU/RSUP Haji Adam Malik Medan外科进行,研究伦理准则为426/KEPK/USU/2022。本研究的对象是2015年1月至2017年12月在棉兰Haji Adam Malik医院骨科接受治疗的骨肉瘤患者,符合纳入标准。结果:ALP、LDH与5年生存率无显著相关性,p值分别为0.557、0.179 (p>0.05)。ALP与5年生存率相关性较弱,r值为-0.019,即ALP越高,患者5年生存率越低。同时,LDH与r值为0.093的相关性较弱,LDH越高,患者5年生存率越高。本研究ALP值中位数为212 U/L, LDH值中位数为489 U/L。ALP的敏感性为61.1%,特异性为57.1%,临界值为217.5 U/L。LDH敏感性为61.2%,特异性为51.4%,临界值为488.5 U/L。结论:ALP和LDH与5年生存率无显著关系。
{"title":"ASSOCIATION BETWEEN SERUM ALP LEVELS AND PRE-OPERATIVE LDH TOWARDS CLINICAL PROGNOSIS OF OSTEOSARCOMA PATIENTS IN H. ADAM MALIK HOSPITAL, MEDAN","authors":"Gerhard Christoffel Tampubolon, Otman Siregar, Andriandi","doi":"10.32734/sumej.v6i1.8991","DOIUrl":"https://doi.org/10.32734/sumej.v6i1.8991","url":null,"abstract":"Background: The prognosis of osteosarcoma is very unsatisfactory due to frequent tumor metastases to the lung or resistance to chemotherapy. A marker is needed to identify the prognosis of patients with osteosarcoma when diagnosed with the aim of being able to receive cancer treatment as soon as possible to improve a better prognosis. Alkaline phosphatase (ALP) and Lactate dehydrogenase (LDH) have potential in assessing the prognosis in osteosarcoma. \u0000Purpose and Objectives: The researcher wanted to investigate the relationship between preoperative serum ALP and LDH levels on the clinical prognosis of osteosarcoma patients. \u0000Methods: This research is analytic retrospective with the source of data is medical records and was conducted at the Department of Surgery FK-USU/RSUP Haji Adam Malik Medan with research code of ethics No. 426/KEPK/USU/2022. The subjects of this study were patients with osteosarcoma who were treated at Division of Orthopedic Surgery at Haji Adam Malik Hospital Medan from January 2015-December 2017 who met the inclusion criteria. \u0000Results: There was no significant relationship between ALP and LDH with five-year survival with p-values ​​of 0.557 and 0.179 (p>0.05). ALP has a weak correlation with five-year survival with an r value of -0.019 which means the higher the ALP, the lower the five-year survival of the patient. Meanwhile, LDH has a weak correlation with an r value of 0.093, which means the higher the LDH, the higher the patient's five-year survival. The ALP value in this study had a median value of 212 U/L and an LDH value of 489 U/L. ALP has sensitivity of 61.1% and specificity of 57.1% with a cut-off of 217.5 U/L. Meanwhile, LDH sensitivity was 61.2% and specificity was 51.4% with a cut-off of 488.5 U/L. \u0000Conclusion: There is no significant relationship between ALP and LDH with five-year survival.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115494260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Risk Factors Associated with Maskne in the Era of the COVID-19 Pandemic 新冠肺炎大流行时代口罩相关风险因素分析
Pub Date : 2023-03-02 DOI: 10.32734/sumej.v6i1.8015
S. Az-Zahra, N. K. Jusuf
The necessity to always use a mask in the era of the COVID-19 pandemic has given rise to a new term called maskne. Maskne is the appearance of acne that is triggered by wearing a mask. It usually occurs specifically in the area covered by the mask, focused on the cheeks, chin, and nose. This study aims to determine the risk factors associated with the occurrence of maskne. A cross-sectional study was conducted on the Faculty of Medicine students, Universitas Sumatera Utara class 2018. This study uses primary data from questionnaires and observation of respondents' face photos. Based on statistical analysis, 99 out of 221 respondents (44.8%) experienced maskne. Bivariate analysis shows p-values <0.05  for gender, duration of mask use, and previous acne history. On the other hand, it was obtained p-value >0.05 for the type of mask and mask changing habit. Based on multivariate analysis, the p-value <0.05 for gender indicates that gender is the most dominant risk factor in the incidence of maskne. Furthermore, there is a significant association between gender and the occurrence of maskne. Females are twice as likely to experience maskne.
在新型冠状病毒感染症(COVID-19)大流行的时代,人们总是需要戴口罩,因此出现了“口罩”(mask)这个新名词。“面具”指的是戴上面具后出现的痤疮。它通常特别发生在口罩覆盖的区域,集中在脸颊、下巴和鼻子上。本研究旨在确定与口罩发生相关的危险因素。对苏门答腊北方大学医学院2018级学生进行了横断面研究。本研究使用问卷调查和观察受访者的面部照片的主要数据。根据统计分析,221名受访者中有99人(44.8%)戴过口罩。双变量分析显示,口罩类型和口罩更换习惯的p值为0.05。多因素分析显示,性别的p值<0.05,表明性别是影响口罩发病率的最主要危险因素。此外,性别与口罩的发生有显著的关联。女性戴口罩的可能性是男性的两倍。
{"title":"Analysis of Risk Factors Associated with Maskne in the Era of the COVID-19 Pandemic","authors":"S. Az-Zahra, N. K. Jusuf","doi":"10.32734/sumej.v6i1.8015","DOIUrl":"https://doi.org/10.32734/sumej.v6i1.8015","url":null,"abstract":"The necessity to always use a mask in the era of the COVID-19 pandemic has given rise to a new term called maskne. Maskne is the appearance of acne that is triggered by wearing a mask. It usually occurs specifically in the area covered by the mask, focused on the cheeks, chin, and nose. This study aims to determine the risk factors associated with the occurrence of maskne. A cross-sectional study was conducted on the Faculty of Medicine students, Universitas Sumatera Utara class 2018. This study uses primary data from questionnaires and observation of respondents' face photos. Based on statistical analysis, 99 out of 221 respondents (44.8%) experienced maskne. Bivariate analysis shows p-values <0.05  for gender, duration of mask use, and previous acne history. On the other hand, it was obtained p-value >0.05 for the type of mask and mask changing habit. Based on multivariate analysis, the p-value <0.05 for gender indicates that gender is the most dominant risk factor in the incidence of maskne. Furthermore, there is a significant association between gender and the occurrence of maskne. Females are twice as likely to experience maskne.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"1578 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127889404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Level of Knowledge among Medical Student Regarding The Role of Vitamin C For Skin Health in Universitas Sumatera Utara 苏门答腊北方大学医学生关于维生素C对皮肤健康作用的知识水平
Pub Date : 2022-11-10 DOI: 10.32734/sumej.v5i1.6514
Hening Yumi, Wardoyo Putri, Nova Z airina Lubis
BACKGROUND: The main function of vitamin C for skin health is as an antioxidant, combating environmental oxidative stress, which helps the natural regeneration of environmental oxidative stressors, collagen formation and brightening the skin. Humans cannot synthesize their own vitamin C, so to meet the vitamin C needs of the body, humans must consume vitamin C from fresh fruits and vegetables. In addition to oral and topical use, the practice of using vitamin C by injection has also been widely spread in major cities in Indonesia. Taking vitamin C is not something bad, but using vitamin C that is not according to the recommended dosage can have unwanted effects on health. OBJECTIVE: This study aims to determine the level of knowledge of students at the Faculty of Medicine, Universitas Sumatera Utara to regarding the role of vitamin C for skin health in 2020. METHODS: This study used a descriptive observational method with a cross sectional design. The sample size in this study was 247 people. The samples used were students of Faculty of Medicine at the Universitas Sumatera Utara class 2017, 2018, and 2019. Data on student knowledge levels collected from the results of filling out the questionnaire will be grouped using the Guttman scale and forwarded for further data processing using the Statistical Package for Social Sciences (SPSS) program 25 . RESULTS : In this study it was found that 86.3% of respondents had sufficient knowledge about the role of vitamin C for skin health, 91.2% of female respondents had sufficient knowledge, 81.5% of male respondents had sufficient knowledge. Based on how to use vitamin C, it can be seen that 41.9% of students have high knowledge about the use of vitamin C orally, 60% of respondents have sufficient knowledge about the use of vitamin C topically, and 50.4% of respondents have sufficient knowledge about its use vitamin C by injection. CONCLUSION: The level of knowledge of students at the Faculty of Medicine at the Universitas Sumatera Utara, for 2017, 2018 and 2019 regarding the role of vitamin C for skin health is sufficient. There are differences in the level of knowledge according to gender in this study, it was found that women have a better level of knowledge than men.
背景:维生素C对皮肤健康的主要作用是作为一种抗氧化剂,对抗环境氧化应激,有助于环境氧化应激源的自然再生,胶原蛋白的形成和美白皮肤。人体自身不能合成维生素C,为了满足人体对维生素C的需要,必须从新鲜水果和蔬菜中摄取维生素C。除了口服和局部使用外,通过注射使用维生素C的做法也在印度尼西亚的主要城市广泛传播。服用维生素C并不是什么坏事,但如果不按照推荐剂量服用维生素C,就会对健康产生不良影响。目的:本研究旨在了解2020年苏门答腊北方大学医学院学生对维生素C对皮肤健康作用的认知水平。方法:采用横断面设计的描述性观察方法。这项研究的样本量是247人。使用的样本是苏门答腊北方大学医学院2017级、2018级和2019级的学生。从填写问卷的结果中收集的学生知识水平数据将使用Guttman量表进行分组,并转发给使用社会科学统计软件包(SPSS)程序进行进一步的数据处理25。结果:本研究发现,86.3%的受访者对维生素C对皮肤健康的作用有足够的了解,其中女性受访者有足够的了解的比例为91.2%,男性受访者有足够的了解的比例为81.5%。从维生素C的使用情况可以看出,41.9%的学生对口服使用维生素C有较高的知识,60%的受访者对局部使用维生素C有足够的知识,50.4%的受访者对注射使用维生素C有足够的知识。结论:2017年、2018年和2019年,苏门答腊北方大学医学院学生对维生素C对皮肤健康的作用的知识水平是足够的。在本研究中,知识水平存在性别差异,发现女性的知识水平高于男性。
{"title":"Level of Knowledge among Medical Student Regarding The Role of Vitamin C For Skin Health in Universitas Sumatera Utara","authors":"Hening Yumi, Wardoyo Putri, Nova Z airina Lubis","doi":"10.32734/sumej.v5i1.6514","DOIUrl":"https://doi.org/10.32734/sumej.v5i1.6514","url":null,"abstract":"BACKGROUND: The main function of vitamin C for skin health is as an antioxidant, combating environmental oxidative stress, which helps the natural regeneration of environmental oxidative stressors, collagen formation and brightening the skin. Humans cannot synthesize their own vitamin C, so to meet the vitamin C needs of the body, humans must consume vitamin C from fresh fruits and vegetables. In addition to oral and topical use, the practice of using vitamin C by injection has also been widely spread in major cities in Indonesia. Taking vitamin C is not something bad, but using vitamin C that is not according to the recommended dosage can have unwanted effects on health. \u0000OBJECTIVE: This study aims to determine the level of knowledge of students at the Faculty of Medicine, Universitas Sumatera Utara to regarding the role of vitamin C for skin health in 2020. \u0000METHODS: This study used a descriptive observational method with a cross sectional design. The sample size in this study was 247 people. The samples used were students of Faculty of Medicine at the Universitas Sumatera Utara class 2017, 2018, and 2019. Data on student knowledge levels collected from the results of filling out the questionnaire will be grouped using the Guttman scale and forwarded for further data processing using the Statistical Package for Social Sciences (SPSS) program 25 . \u0000RESULTS : In this study it was found that 86.3% of respondents had sufficient knowledge about the role of vitamin C for skin health, 91.2% of female respondents had sufficient knowledge, 81.5% of male respondents had sufficient knowledge. Based on how to use vitamin C, it can be seen that 41.9% of students have high knowledge about the use of vitamin C orally, 60% of respondents have sufficient knowledge about the use of vitamin C topically, and 50.4% of respondents have sufficient knowledge about its use vitamin C by injection. \u0000CONCLUSION: The level of knowledge of students at the Faculty of Medicine at the Universitas Sumatera Utara, for 2017, 2018 and 2019 regarding the role of vitamin C for skin health is sufficient. There are differences in the level of knowledge according to gender in this study, it was found that women have a better level of knowledge than men.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125999730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPARISON OF ASSESSMENT OF ABBREVIATED BURN SEVERITY INDEX (ABSI) AND BELGIAN OUTCOME OF BURN INJURY (BOBI) AT H. ADAM MALIK GENERAL HOSPITAL 亚当马利克总医院烧伤严重程度指数(absi)与比利时烧伤预后(bobi)评定的比较
Pub Date : 2022-11-10 DOI: 10.32734/sumej.v5i2.8966
Rifwanul Basir Nasution
Background: Assessment of length of stay and mortality in patients with burn injuries is essential to support clinicians in making clinical decisions. In Indonesia, there are several scoring systems used by hospital centers to assess the mortality of burn patients, such as the Belgian Outcome of Burn Injury (BOBI) and the Abbreviated Burn Severity Index (ABSI). However, different results were obtained in studies that examined the comparison of the results of the scoring system. Method: The type of research used in this research is unpaired comparative analysis research using a cross-sectional design. The data to be used is secondary data taken from medical records. Results: Respondents with death status were found in the serious, severe, and maximum ABSI categories, p=0.001 (p<0.05) and the BOBI 50% category as many as three people and 85% as many as one person, p=0.0001 (0<0.05). Length of stay based on the ABSI score for the length of stay was 23 days with an ABSI score of 12-13 (maximum), and based on the BOBI Score, the majority was 28 days with a BOBI score of 8 (85%). ABSI in this study had a sensitivity of 100% and a specificity of 86.4%, while the use of BOBI in this study had a sensitivity of 100% and a specificity of 88.1%. Discussion: The BOBI scoring system is more accurate than the ABSI. This difference may occur due to differences in demographics and quality of service in each region. Therefore, the analysis of the validity of the scoring model before the research is carried out in a new population is considered crucial to be carried out.
背景:评估烧伤患者的住院时间和死亡率对于支持临床医生做出临床决策至关重要。在印度尼西亚,医院中心使用了几种评分系统来评估烧伤患者的死亡率,例如比利时烧伤结局(BOBI)和简略烧伤严重程度指数(ABSI)。然而,在检查评分系统结果比较的研究中获得了不同的结果。方法:本研究采用的研究类型是采用横断面设计的非配对比较分析研究。使用的数据是从医疗记录中获取的辅助数据。结果:重度、重度和最大ABSI类别均有死亡状态的应答者,p=0.001 (p<0.05); BOBI 50%类别最多3人,85%最多1人,p=0.0001(0<0.05)。基于ABSI评分的停留时间为23天,ABSI评分为12-13分(最大值);基于BOBI评分,大多数为28天,BOBI评分为8分(85%)。本研究中使用ABSI的敏感性为100%,特异性为86.4%,而使用BOBI的敏感性为100%,特异性为88.1%。讨论:BOBI评分系统比ABSI更准确。这种差异可能是由于每个地区的人口统计和服务质量的差异造成的。因此,在新的人群中进行研究之前,对评分模型的有效性进行分析是至关重要的。
{"title":"COMPARISON OF ASSESSMENT OF ABBREVIATED BURN SEVERITY INDEX (ABSI) AND BELGIAN OUTCOME OF BURN INJURY (BOBI) AT H. ADAM MALIK GENERAL HOSPITAL","authors":"Rifwanul Basir Nasution","doi":"10.32734/sumej.v5i2.8966","DOIUrl":"https://doi.org/10.32734/sumej.v5i2.8966","url":null,"abstract":"Background: Assessment of length of stay and mortality in patients with burn injuries is essential to support clinicians in making clinical decisions. In Indonesia, there are several scoring systems used by hospital centers to assess the mortality of burn patients, such as the Belgian Outcome of Burn Injury (BOBI) and the Abbreviated Burn Severity Index (ABSI). However, different results were obtained in studies that examined the comparison of the results of the scoring system. \u0000Method: The type of research used in this research is unpaired comparative analysis research using a cross-sectional design. The data to be used is secondary data taken from medical records. \u0000Results: Respondents with death status were found in the serious, severe, and maximum ABSI categories, p=0.001 (p<0.05) and the BOBI 50% category as many as three people and 85% as many as one person, p=0.0001 (0<0.05). Length of stay based on the ABSI score for the length of stay was 23 days with an ABSI score of 12-13 (maximum), and based on the BOBI Score, the majority was 28 days with a BOBI score of 8 (85%). ABSI in this study had a sensitivity of 100% and a specificity of 86.4%, while the use of BOBI in this study had a sensitivity of 100% and a specificity of 88.1%. \u0000Discussion: The BOBI scoring system is more accurate than the ABSI. This difference may occur due to differences in demographics and quality of service in each region. Therefore, the analysis of the validity of the scoring model before the research is carried out in a new population is considered crucial to be carried out.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"11 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120930474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASSOCIATION OF GLYCOSYLLATED HEMOGLOBIN (HbA1C) LEVELS TO THE SEVERITY OF DIABETIC FOOT ULCER IN TYPE 2 DIABETES MELLITUS PATIENTS IN RSUP. H. ADAM MALIK MEDAN 糖化血红蛋白(HbA1C)水平与RSUP中2型糖尿病患者糖尿病足溃疡严重程度的关系。亚当·马利克·梅丹
Pub Date : 2022-11-10 DOI: 10.32734/sumej.v5i1.9060
Muhammad Imran Porkas Lubis
Abstrak Introduction: Diabetic ulcers with neuropathy require amputation or time to fully heal. The worse blood sugar control, it will worsen the condition of complications such as diabetic ulcers, diabetic neuropathy, and other complications. Wound healing in diabetic ulcers is influenced by controlled HbA1c levels. Methods: This study is an observational analytic study with a retrospective design used in this study with secondary data. This study is analytical because it aims to obtain the correlation of HbA1c with the severity of diabetic ulcers in patients with diabetes mellitus at H. Adam Malik Hospital. Results: The average age of the patients was 62 with the majority of respondents being male. The dominance of respondents came with Grade IV as many as 17 people, with uncontrolled HbA1c levels as many as 39 people. Using Spearman Corelation test, the value of r = 0.735, 0.736, and 0.785, respecttively for the corelation between HbA1c, Hb and ESR levels with the severity of diabetic foot ulcers ,with a value (p = 0.0001). Conclusion: We found a strong correlation and a significant relationship between HbA1c, Hb, and ESR levels with the severity of diabetic foot ulcers.
摘要简介:伴有神经病变的糖尿病溃疡需要截肢或一定时间才能完全愈合。血糖控制越差,就会加重糖尿病溃疡、糖尿病性神经病变等并发症的情况。糖尿病溃疡的伤口愈合受控制的HbA1c水平的影响。方法:本研究为观察性分析研究,采用回顾性设计,采用二次资料。这项研究是分析性的,因为它的目的是获得HbA1c与H. Adam Malik医院糖尿病患者糖尿病溃疡严重程度的相关性。结果:患者平均年龄62岁,男性居多。IV级患者占多数,多达17人,HbA1c水平不受控制的多达39人。采用Spearman相关检验,HbA1c、Hb、ESR水平与糖尿病足溃疡严重程度的相关性r值分别为0.735、0.736、0.785,p值为0.0001。结论:我们发现HbA1c、Hb和ESR水平与糖尿病足溃疡的严重程度有很强的相关性和显著的相关性。
{"title":"ASSOCIATION OF GLYCOSYLLATED HEMOGLOBIN (HbA1C) LEVELS TO THE SEVERITY OF DIABETIC FOOT ULCER IN TYPE 2 DIABETES MELLITUS PATIENTS IN RSUP. H. ADAM MALIK MEDAN","authors":"Muhammad Imran Porkas Lubis","doi":"10.32734/sumej.v5i1.9060","DOIUrl":"https://doi.org/10.32734/sumej.v5i1.9060","url":null,"abstract":"Abstrak \u0000Introduction: Diabetic ulcers with neuropathy require amputation or time to fully heal. The worse blood sugar control, it will worsen the condition of complications such as diabetic ulcers, diabetic neuropathy, and other complications. Wound healing in diabetic ulcers is influenced by controlled HbA1c levels. \u0000Methods: This study is an observational analytic study with a retrospective design used in this study with secondary data. This study is analytical because it aims to obtain the correlation of HbA1c with the severity of diabetic ulcers in patients with diabetes mellitus at H. Adam Malik Hospital. \u0000Results: The average age of the patients was 62 with the majority of respondents being male. The dominance of respondents came with Grade IV as many as 17 people, with uncontrolled HbA1c levels as many as 39 people. Using Spearman Corelation test, the value of r = 0.735, 0.736, and 0.785, respecttively for the corelation between HbA1c, Hb and ESR levels with the severity of diabetic foot ulcers ,with a value (p = 0.0001). \u0000Conclusion: We found a strong correlation and a significant relationship between HbA1c, Hb, and ESR levels with the severity of diabetic foot ulcers.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"199 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124449921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report VP shunt in Non Communicating Hydrocephalus due to Intracerebral Hemorrhage 脑出血所致非交通性脑积水静脉分流一例报告
Pub Date : 2022-11-10 DOI: 10.32734/sumej.v5i1.9383
F. Muharam, Rully Hanafi Dahlan, Seyline Estethia Ompusunggu
Stroke is one of the top three cause of death and disability globally. Approximately, only 10% to 15% of first-ever stroke are intracerebral hemorrhages (ICHs), but the rates of disability and death are significantly higher. Hydrocephalus may occur in more than 50% of patients with intraventricular hemorrhage (IVH), which is secondary to ICH.  Intraventricular hemorrhage (IVH), an accumulation of blood to ventricles that may be cause by extension of ICH, occurs in up to 50% of patients with primary ICH.  Hydrocephalus itself may serves as a predictor of poor outcome after ICH.1,2,3 A 71 years old male came to the hospital with the complaint of loss of consciousness, difficulty in communicating, and weakness of extremities on the left side of the body since 12 hours ago. The complaint was preceded by headache that did not alleviate with medication since 1 day before admission and there was history of slurred speech. A head CT scan without contrast was done and the result showed an intracerebral hemorrhage and a suggestive obstructive hydrocephalus. The patient was diagnosed noncommunicating hydrocephalus due to spontaneous intracerebral haemorrhage (ICH) at the right thalamus with intraventricular haemorrhage due to suspect hypertension with differential diagnosis of cerebral amyloid angiopathy with emergency hypertension. The patient was advised to underwent an emergency VP shunt placement. Implantation of a ventriculoperitoneal (VP) shunt is the most widely used treatment of hydrocephalus. Considered to be a major privonce of neurosurgery, it accounts for 70.000 hospital admission in the US. Even though, VP shunting of CSF reduces the morbidity and mortality of post-hemorrhagic. hydrocephalus, it is associated with potential complications requiring multiple surgical procedures, as well as shunt revision due to its failure during the patient’s lifetime.4
中风是全球死亡和残疾的三大原因之一。大约只有10%到15%的首次中风是脑出血,但致残率和死亡率要高得多。脑积水可能发生在超过50%的脑室内出血(IVH)患者,这是继发于脑出血。脑室内出血(IVH),一种血液向脑室积聚,可能是由脑出血扩大引起的,在原发性脑出血患者中发生的比例高达50%。脑积水本身可能是颅内出血后预后不良的一个预测因素。1,2,3 1名71岁男性,12小时前来医院就诊,主诉意识丧失,沟通困难,左侧肢体无力。主诉为入院前1天头痛,用药未见缓解,有口齿不清病史。头部CT扫描未做对比,结果显示脑出血和提示梗阻性脑积水。患者诊断为右丘脑自发性脑出血(ICH)所致的非交通性脑积水,合并疑似高血压所致的脑室内出血,鉴别诊断为脑淀粉样血管病合并急诊高血压。建议患者接受紧急VP分流安置。脑室-腹膜(VP)分流术是脑积水最广泛使用的治疗方法。它被认为是神经外科的一个主要领域,在美国有7万人住院。尽管如此,脑脊液的VP分流降低了出血后的发病率和死亡率。脑积水与潜在的并发症相关,需要多次外科手术,以及由于患者一生中失败而进行分流翻修
{"title":"A Case Report VP shunt in Non Communicating Hydrocephalus due to Intracerebral Hemorrhage","authors":"F. Muharam, Rully Hanafi Dahlan, Seyline Estethia Ompusunggu","doi":"10.32734/sumej.v5i1.9383","DOIUrl":"https://doi.org/10.32734/sumej.v5i1.9383","url":null,"abstract":"Stroke is one of the top three cause of death and disability globally. Approximately, only 10% to 15% of first-ever stroke are intracerebral hemorrhages (ICHs), but the rates of disability and death are significantly higher. Hydrocephalus may occur in more than 50% of patients with intraventricular hemorrhage (IVH), which is secondary to ICH.  Intraventricular hemorrhage (IVH), an accumulation of blood to ventricles that may be cause by extension of ICH, occurs in up to 50% of patients with primary ICH.  Hydrocephalus itself may serves as a predictor of poor outcome after ICH.1,2,3 \u0000A 71 years old male came to the hospital with the complaint of loss of consciousness, difficulty in communicating, and weakness of extremities on the left side of the body since 12 hours ago. The complaint was preceded by headache that did not alleviate with medication since 1 day before admission and there was history of slurred speech. A head CT scan without contrast was done and the result showed an intracerebral hemorrhage and a suggestive obstructive hydrocephalus. The patient was diagnosed noncommunicating hydrocephalus due to spontaneous intracerebral haemorrhage (ICH) at the right thalamus with intraventricular haemorrhage due to suspect hypertension with differential diagnosis of cerebral amyloid angiopathy with emergency hypertension. The patient was advised to underwent an emergency VP shunt placement. \u0000Implantation of a ventriculoperitoneal (VP) shunt is the most widely used treatment of hydrocephalus. Considered to be a major privonce of neurosurgery, it accounts for 70.000 hospital admission in the US. Even though, VP shunting of CSF reduces the morbidity and mortality of post-hemorrhagic. hydrocephalus, it is associated with potential complications requiring multiple surgical procedures, as well as shunt revision due to its failure during the patient’s lifetime.4","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124138638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RISK FACTOR ANALYSIS OF LOW BACK PAIN IN EMPLOYEES OF DRINKING WATER STORE IN MEDAN SELAYANG SUB-DISTRICT 棉兰市色阳街道饮用水商店员工腰痛危险因素分析
Pub Date : 2022-09-01 DOI: 10.32734/sumej.v5i3.8040
Andri Josua Barutu, Heru Rahmadhany
Background. Low back pain is defined as feeling of pain and discomfort in the area between the costal margin and inferior gluteal fold, with or without radiating pain. In Indonesia, LBP was fifth ranks in term of disability-adjusted life years (DALYs). Aim. This study aims to determine risk factors for LBP in employees of drinking water store in Medan Selayang sub-District, Medan. Method. This research is an observational analytic study with cross-sectional design. This study used consecutive sampling method. Minimum sample size in this study was 97 samples. Subjects in this study were employees of drinking water store in Medan Selayang sub-District. Data used in this study was primary data from samples through filling out questionnaires. Analysis used in this study was univariate analysis, bivariate with chi-square, and multivariate with logistic regression. Result. From 100 samples, 39 respondents (39%) experienced LBP. Based on bivariate analisis, p value ≤ 0.05 was found  for age, body mass index, and duration of work. P value ≥ 0.05 was obtained for years of work and lifting frequency. Based on multivariate analysis with regression logistic, p value ≤ 0.05 was obtained for body mass index (p = 0.089) and work duration (p = 0.011) which indicated that work duration was the most dominant risk factor. Conclusion. There’s a relationship between age, body mass index, and work duration with the work duration being the most dominant risk factor for the incidence of low back pain in water gallon worker. .  
背景。腰痛定义为肋缘至臀下褶之间区域的疼痛和不适感,伴或不伴放射性疼痛。在印度尼西亚,LBP在残疾调整生命年(DALYs)方面排名第五。的目标。本研究旨在了解棉兰市Selayang街道饮用水商店员工LBP的危险因素。方法。本研究为横断面设计的观察性分析研究。本研究采用连续抽样方法。本研究最小样本量为97个样本。本研究以棉兰市色拉阳街道饮用水商店员工为研究对象。本研究使用的数据是通过填写问卷从样本中获得的原始数据。本研究采用单因素分析、双因素卡方分析和多因素logistic回归分析。结果。在100个样本中,39名受访者(39%)经历过LBP。基于双变量分析,年龄、体重指数和工作时间的p值≤0.05。工作年限和起重频率P值均≥0.05。多因素logistic回归分析显示,体重指数(p = 0.089)和工作时长(p = 0.011)的p值≤0.05,表明工作时长是最主要的危险因素。结论。年龄、体重指数和工作时长之间存在一定的关系,其中工作时长是影响水工腰痛发病的最主要危险因素。
{"title":"RISK FACTOR ANALYSIS OF LOW BACK PAIN IN EMPLOYEES OF DRINKING WATER STORE IN MEDAN SELAYANG SUB-DISTRICT","authors":"Andri Josua Barutu, Heru Rahmadhany","doi":"10.32734/sumej.v5i3.8040","DOIUrl":"https://doi.org/10.32734/sumej.v5i3.8040","url":null,"abstract":"Background. Low back pain is defined as feeling of pain and discomfort in the area between the costal margin and inferior gluteal fold, with or without radiating pain. In Indonesia, LBP was fifth ranks in term of disability-adjusted life years (DALYs). Aim. This study aims to determine risk factors for LBP in employees of drinking water store in Medan Selayang sub-District, Medan. Method. This research is an observational analytic study with cross-sectional design. This study used consecutive sampling method. Minimum sample size in this study was 97 samples. Subjects in this study were employees of drinking water store in Medan Selayang sub-District. Data used in this study was primary data from samples through filling out questionnaires. Analysis used in this study was univariate analysis, bivariate with chi-square, and multivariate with logistic regression. Result. From 100 samples, 39 respondents (39%) experienced LBP. Based on bivariate analisis, p value ≤ 0.05 was found  for age, body mass index, and duration of work. P value ≥ 0.05 was obtained for years of work and lifting frequency. Based on multivariate analysis with regression logistic, p value ≤ 0.05 was obtained for body mass index (p = 0.089) and work duration (p = 0.011) which indicated that work duration was the most dominant risk factor. Conclusion. There’s a relationship between age, body mass index, and work duration with the work duration being the most dominant risk factor for the incidence of low back pain in water gallon worker. .  ","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133125285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Relationship Between Diabetic Retinopathy Degree With Visual Acuity And Retinal Nerve Fiber Layer Thickness In Type 2 Diabetes Mellitus Patients 2型糖尿病视网膜病变程度与视力及视网膜神经纤维层厚度的关系
Pub Date : 2022-09-01 DOI: 10.32734/sumej.v5i3.9190
Felanda Ahsanu Nadia
Introduction: Diabetic retinopathy is an ocular complication of diabetes mellitus (DM), and is one of the leading causes of visual impairment and blindness worldwide.. More than one third of people with diabetes have signs of diabetic retinopathy.   Methods: This was an analytic observational study with cross-sectional design. The sample was type 2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University of Sumatera Utara General Hospital from September 2021-December 2021. The sample were then analyzed with the Mann-Whitney and Kruskal Wallis test to find the relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients.   Results: The sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabetic retinopathy as the control group. The mean visual acuity in subjects with mild diabetic retinopathy was 0.65+0.48. Average visual acuity in subjects with the degree of moderate diabetic retinopathy was 0.83+0.46. The mean visual acuity in subjects with a proliferative degrees diabetic retinopathy was 0.77+0.64. Mann Whitney test revealed no statistically significant relationship between the degree of diabetic retinopathy and visual acuity (p=0.734). Using the Kruskal Wallis test revealed that there was no significant relationship between the degree of retinopathy diabetic with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111), temporal RNFL (p=0.064), nasal RNFL (p=0.535).   Discussion: Controlling blood glucose levels becomes more important than the duration of diabetes in preventing the development of retinopathy. Most patients are advised to have an HbA1c of 7% or lower, and for certain patients it is recommended to be lower than6.5%. Diabetic retinopathy slowly damages the retinal blood vessels or the optic nerve layer, leading to leakage, thus resulting in accumulation of fluid containing lipid and blood in the retina which will gradually lead to visual impairment, and even blindness.   Conclusion: There is no significant relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients.
简介:糖尿病视网膜病变是糖尿病(DM)的眼部并发症,是世界范围内视力损害和失明的主要原因之一。超过三分之一的糖尿病患者有糖尿病视网膜病变的症状。方法:采用横断面设计的分析观察性研究。样本为2021年9月至2021年12月在苏门答腊北方大学总医院眼科诊所就诊的伴有糖尿病视网膜病变的2型糖尿病患者。然后用Mann-Whitney和Kruskal Wallis检验分析2型糖尿病视网膜病变程度与视力和视网膜神经纤维层厚度的关系。结果:本研究以20名糖尿病视网膜病变患者和20名非糖尿病视网膜病变患者为对照组。轻度糖尿病视网膜病变患者的平均视力为0.65+0.48。中度糖尿病视网膜病变患者的平均视力为0.83+0.46。增生性糖尿病视网膜病变患者的平均视力为0.77+0.64。Mann Whitney检验显示糖尿病视网膜病变程度与视力无统计学意义(p=0.734)。Kruskal - Wallis检验显示糖尿病视网膜病变程度与Avg RNFL (p=0.495)、高级RNFL (p=0.385)、低级RNFL (p=0.111)、颞部RNFL (p=0.064)、鼻腔RNFL (p=0.535)无显著相关。讨论:在预防视网膜病变方面,控制血糖水平比控制糖尿病病程更为重要。大多数患者建议HbA1c为7%或更低,某些患者建议低于6.5%。糖尿病性视网膜病变会缓慢损害视网膜血管或视神经层,导致渗漏,从而导致含脂和含血的液体在视网膜内积聚,逐渐导致视力受损,甚至失明。结论:2型糖尿病视网膜病变程度与视敏度、视网膜神经纤维层厚度无明显关系。
{"title":"The Relationship Between Diabetic Retinopathy Degree With Visual Acuity And Retinal Nerve Fiber Layer Thickness In Type 2 Diabetes Mellitus Patients","authors":"Felanda Ahsanu Nadia","doi":"10.32734/sumej.v5i3.9190","DOIUrl":"https://doi.org/10.32734/sumej.v5i3.9190","url":null,"abstract":"Introduction: Diabetic retinopathy is an ocular complication of diabetes mellitus (DM), and is one of the leading causes of visual impairment and blindness worldwide.. More than one third of people with diabetes have signs of diabetic retinopathy. \u0000  \u0000Methods: This was an analytic observational study with cross-sectional design. The sample was type 2 diabetes mellitus patients with diabetic retinopathy who visited the eye clinic at the University of Sumatera Utara General Hospital from September 2021-December 2021. The sample were then analyzed with the Mann-Whitney and Kruskal Wallis test to find the relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients. \u0000  \u0000Results: The sample of this study were 20 subjects with diabetic retinopathy and 20 subjects without diabetic retinopathy as the control group. The mean visual acuity in subjects with mild diabetic retinopathy was 0.65+0.48. Average visual acuity in subjects with the degree of moderate diabetic retinopathy was 0.83+0.46. The mean visual acuity in subjects with a proliferative degrees diabetic retinopathy was 0.77+0.64. Mann Whitney test revealed no statistically significant relationship between the degree of diabetic retinopathy and visual acuity (p=0.734). Using the Kruskal Wallis test revealed that there was no significant relationship between the degree of retinopathy diabetic with Avg RNFL (p=0.495), superior RNFL (p=0.385), inferior RNFL (p=0.111), temporal RNFL (p=0.064), nasal RNFL (p=0.535). \u0000  \u0000Discussion: Controlling blood glucose levels becomes more important than the duration of diabetes in preventing the development of retinopathy. Most patients are advised to have an HbA1c of 7% or lower, and for certain patients it is recommended to be lower than6.5%. Diabetic retinopathy slowly damages the retinal blood vessels or the optic nerve layer, leading to leakage, thus resulting in accumulation of fluid containing lipid and blood in the retina which will gradually lead to visual impairment, and even blindness. \u0000  \u0000Conclusion: There is no significant relationship between diabetic retinopathy degree with visual acuity and retinal nerve fiber layer thickness in type 2 diabetes mellitus patients.","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116690275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Comparison Level of Parent’s Knowledge Towards Interdigital Tinea Pedis (Athlete’s foot) in Parents with and without Interdigital Tinea Pedis in Namu Trasi Namu Trasi地区有、无趾间足癣家长对足癣(脚癣)认知水平的比较
Pub Date : 2022-09-01 DOI: 10.32734/sumej.v5i3.7925
Meirin Yustisya
Background: Tinea pedis occurs in 30-70% of the world's population. In Indonesia, some data are known, such as statistical data on the prevalence of tinea pedis in several teaching hospitals, such as RS. Dr. Soetomo, RSCM, RS. Dr. Hasan Sadikin, RS. Dr. Sardjito obtained a relative yield of 16%. Therefore, public knowledge about tinea pedis is something that is very relatively owned by the community to respond to, control, and prevents the occurrence of tinea pedis. Objective: The purpose of this study was to compare the level of parental knowledge of Interdigital Tinea Pedis (Athlete’s foot) in parents with and without Interdigital Tinea pedis in Namu Trasi. Method: This research was conducted using an analytical method of cross-sectional design with a collection technique using a questionnaire to be filled out by the respondent and then analyzed using a statistical program application.  Results: The level of knowledge of parents with and without Interdigital Tinea pedis in Namu Trasi Village was 45.8% with good knowledge, 34.7% with sufficient knowledge, and 19.4% with poor knowledge. Conclusion: There is a significant difference between the level of parental knowledge of Interdigital Tinea pedis (Athlete’s foot) in patients and non-patients with Interdigital Tinea pedis in Namu Trasi
背景:全世界30-70%的人口患有足癣。在印度尼西亚,一些数据是已知的,例如几家教学医院的足癣患病率统计数据,如RS. Soetomo博士、RSCM、RS. Dr. Hasan Sadikin博士、RS. Dr. Sardjito博士获得了16%的相对收益。因此,公众对足癣的认识是一个非常相对属于社会的事情,去应对、去控制、去预防足癣的发生。目的:本研究的目的是比较在Namu Trasi有和没有趾间足癣的父母对足癣(脚癣)的知识水平。方法:本研究采用横断面设计的分析方法和收集技术,采用问卷调查,由被调查者填写,然后使用统计程序应用程序进行分析。结果:纳木特拉西村家长对足趾间癣和非足趾间癣的了解程度为:良好的占45.8%,充分的占34.7%,较差的占19.4%。结论:纳木特拉西地区足趾间癣患者与非足趾间癣患者父母对足趾间癣(脚癣)的认知水平存在显著差异
{"title":"The Comparison Level of Parent’s Knowledge Towards Interdigital Tinea Pedis (Athlete’s foot) in Parents with and without Interdigital Tinea Pedis in Namu Trasi","authors":"Meirin Yustisya","doi":"10.32734/sumej.v5i3.7925","DOIUrl":"https://doi.org/10.32734/sumej.v5i3.7925","url":null,"abstract":"Background: Tinea pedis occurs in 30-70% of the world's population. In Indonesia, some data are known, such as statistical data on the prevalence of tinea pedis in several teaching hospitals, such as RS. Dr. Soetomo, RSCM, RS. Dr. Hasan Sadikin, RS. Dr. Sardjito obtained a relative yield of 16%. Therefore, public knowledge about tinea pedis is something that is very relatively owned by the community to respond to, control, and prevents the occurrence of tinea pedis. Objective: The purpose of this study was to compare the level of parental knowledge of Interdigital Tinea Pedis (Athlete’s foot) in parents with and without Interdigital Tinea pedis in Namu Trasi. Method: This research was conducted using an analytical method of cross-sectional design with a collection technique using a questionnaire to be filled out by the respondent and then analyzed using a statistical program application.  Results: The level of knowledge of parents with and without Interdigital Tinea pedis in Namu Trasi Village was 45.8% with good knowledge, 34.7% with sufficient knowledge, and 19.4% with poor knowledge. Conclusion: There is a significant difference between the level of parental knowledge of Interdigital Tinea pedis (Athlete’s foot) in patients and non-patients with Interdigital Tinea pedis in Namu Trasi","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115094306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case Report The Evaluation of Malondialdehyde Level on Acne Vulgaris Treatment 丙二醛水平对寻常性痤疮治疗效果的评价1例
Pub Date : 2022-09-01 DOI: 10.32734/sumej.v5i2.6633
Muhammad Ridlo, N. Jusuf
Abstract: Acne vulgaris (AV) is a multifactorial disease of the pilosebaceous unit with varying degrees of severity, recurrent and characterized by polymorphic lesions. Recent studies have found that the etiopathogenesis of AV is caused by oxidative stress. Each factor that causes AV is interrelated and is under the control of hormones and immunity. Measurement of malondialdehyde (MDA) level in the blood becomes a biological marker or an indicator of cell and tissue damage caused by oxidative stress. Case: A 23-years-old female private employee visited the clinic for multiple comedones and papulopustular lesions scattered over cheeks, nose, and chin that spread to the whole face four months ago. There were multiple comedones, papules, pustules, nodules on the maxillary, nasalis, left and right zigomatic, mentalis and frontalis region. We also found multiple scars on the left and right buccal. She was diagnosed with Severe AV. Serum MDA level was measured according to the enzyme-linked immunosorbent assay (ELISA) method before and after therapy. She was treated with doxycycline 100 mg, 0.025% tretinoin cream, 5% benzoyl peroxide, 1.2% clindamycin gel, and broadspectrum sunscreen with SPF 50. Result: After eight weeks of treatment, there were noticeable improvements in acne lesions and overall healthier-looking skin. Serum MDA levels are decreased (22.6 nmol/ml  to 17.9 nmol/ml) as the impact of the therapy. Keyword: Acne Vulgaris, Malondialdehyde, Oxidative Stress
摘要寻常痤疮(Acne vulgaris, AV)是一种多因素的皮脂腺单位疾病,具有不同程度的严重程度、复发性和多形态病变特征。最近的研究发现,AV的发病机制是由氧化应激引起的。导致AV的每个因素都是相互关联的,并受激素和免疫的控制。血液中丙二醛(MDA)水平的测量成为氧化应激引起的细胞和组织损伤的生物学标记或指标。病例:一名23岁女性私人雇员于4个月前来就诊,因多发粉刺及丘疹性病变分布于脸颊、鼻子及下巴,并扩散至全脸。上颌、鼻肌、左右颏肌、额肌区多发粉刺、丘疹、脓疱、结节。我们还在左颊和右颊发现了多处伤疤。采用酶联免疫吸附试验(ELISA)检测治疗前后血清丙二醛(MDA)水平。给予强力霉素100 mg、0.025%维甲酸乳膏、5%过氧化苯甲酰、1.2%克林霉素凝胶、SPF 50的广谱防晒霜。结果:经过八周的治疗,痤疮病变明显改善,整体皮肤看起来更健康。由于治疗的影响,血清MDA水平降低(22.6 nmol/ml至17.9 nmol/ml)。关键词:寻常痤疮,丙二醛,氧化应激
{"title":"A Case Report The Evaluation of Malondialdehyde Level on Acne Vulgaris Treatment","authors":"Muhammad Ridlo, N. Jusuf","doi":"10.32734/sumej.v5i2.6633","DOIUrl":"https://doi.org/10.32734/sumej.v5i2.6633","url":null,"abstract":"Abstract: Acne vulgaris (AV) is a multifactorial disease of the pilosebaceous unit with varying degrees of severity, recurrent and characterized by polymorphic lesions. Recent studies have found that the etiopathogenesis of AV is caused by oxidative stress. Each factor that causes AV is interrelated and is under the control of hormones and immunity. Measurement of malondialdehyde (MDA) level in the blood becomes a biological marker or an indicator of cell and tissue damage caused by oxidative stress. Case: A 23-years-old female private employee visited the clinic for multiple comedones and papulopustular lesions scattered over cheeks, nose, and chin that spread to the whole face four months ago. There were multiple comedones, papules, pustules, nodules on the maxillary, nasalis, left and right zigomatic, mentalis and frontalis region. We also found multiple scars on the left and right buccal. She was diagnosed with Severe AV. Serum MDA level was measured according to the enzyme-linked immunosorbent assay (ELISA) method before and after therapy. She was treated with doxycycline 100 mg, 0.025% tretinoin cream, 5% benzoyl peroxide, 1.2% clindamycin gel, and broadspectrum sunscreen with SPF 50. Result: After eight weeks of treatment, there were noticeable improvements in acne lesions and overall healthier-looking skin. Serum MDA levels are decreased (22.6 nmol/ml  to 17.9 nmol/ml) as the impact of the therapy. \u0000Keyword: Acne Vulgaris, Malondialdehyde, Oxidative Stress","PeriodicalId":184699,"journal":{"name":"Sumatera Medical Journal","volume":"17 15-16","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133170529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Sumatera Medical Journal
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1