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The Presence of Helicobacter pylori in cases of Chronic Tonsillitis in Medan 棉兰地区慢性扁桃体炎患者幽门螺杆菌的检测
Pub Date : 2020-01-29 DOI: 10.32734/SUMEJ.V3I1.2044
Rini Syahrani Harahap, Delyuzar, J. Chrestella
Background: Helicobacter pylori is a well known pathogen which is recognized as the most frequent infection of individuals. Helicobacter pylori plays important role in the etiology og gastritis, gastric and duodenal ulcers. We investigated the presence of Helicobacter pylori as an extragastric reservoir in the tonsilectomy specimens. Aim: To determine the presence of Helicobacter pylori in cases of chronic tonsillitis in tonsilectomy specimens. Methods: This is a descriptive study with cross sectional which the sample will be obtained using consecutive sampling method. We collect 43 cases with chronic tonsilitis were examined in tonsillectomy specimens for which available tissue for routin staining could be retrieved were histopathology chronic tonsillitis. The colonization of the helicobacter pylori have been evaluated with hematoxylin & Eosin and Giemsa stains under the light microscope. Results: With H&E staining, Helicobacter pylori has been detected in 23 cases (53,48%) of the tonsil-lectomy specimens in total. No colonization has been observed in the remaining 20 cases (46,51%). With giemsa staining Helicobacter pylori has been detected in 29 cases (67,74%) of the tonsillectomy specimens in total. No colonization has been observed in the remaining 14 cases (32,55%).   Keywords: Helicobacter pylori, Chronic Tonsillitis, H&E, Giemsa.
背景:幽门螺杆菌是一种众所周知的病原体,被认为是最常见的个体感染。幽门螺杆菌在胃炎、胃溃疡和十二指肠溃疡的病因学中起重要作用。我们调查了扁桃体切除标本中幽门螺杆菌作为胃外储存库的存在。目的:探讨慢性扁桃体炎患者扁桃体切除术标本中幽门螺杆菌的存在情况。方法:采用横断面描述性研究,样本采用连续抽样法获取。我们收集了43例慢性扁桃体炎患者,在扁桃体切除术标本中检查了可用于常规染色的组织,这些组织是组织病理学慢性扁桃体炎。在光镜下用苏木精&伊红染色和吉姆萨染色评价幽门螺杆菌的定植。结果:H&E染色检出幽门螺杆菌23例(53.48%)扁桃体切除标本。其余20例(46.51%)未见定植。29例扁桃体切除标本(67.74%)经吉氏染色检出幽门螺杆菌。其余14例(32.55%)未见定植。关键词:幽门螺杆菌;慢性扁桃体炎;H&E;
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引用次数: 0
Combination Therapy in Melasma with Lentigo Solaris 黄褐斑的联合治疗
Pub Date : 2020-01-29 DOI: 10.32734/SUMEJ.V3I1.690
E. W. Lumbantoruan, K. Nasution, Nelva Karmila Jusuf
Background: Melasma and lentigo solaris are common, recurrent, and refractory acquired hyperpigmentation disorder. In spite of variety of therapeutic options available for this cosmetically disfiguring condition, the treatment of this condition remains a challenge. Azelaic acid (AA) is a depigmenting agent which acts by inhibition of DNA synthesis and mitochondrial enzymes, thereby inducing direct cytotoxic effects on melanocytes. Glycolic acid (GA) peel is one of the most versatile agents in the treatment of melasma and lentigo solaris. GA peels alone or in combination with topical hypopigmenting agents has shown encouraging results. However, there is paucity of controlled trial demonstrating the efficacy of GA peels in conjunction with topical AA. Case: A 42-years-old female, works as a street vendor, came with dark brown spots on both cheeks, nose, chin and forehead that spreads to whole face since one year ago. She had a history of using contraceptives. From the dermatological examination, there were multiple well-circumscribed, irregular hyperpigmented macules that asymmetrical, with size ranging from lenticular to plaque on the maxillary, left buccalis, mentalis and frontalis region. We also found a numular dark brown hyperpigmented macules on right zygoma. She was diagnosed with melasma and lentigo solaris. The Melasma Area Severity Index (MASI) score was 25.6, which classified as moderate melasma. She was treated with 20% azaleic acid cream twice a day, broadspectrum sunscreen with SPF 50 and GA 20% peeling. Result: After 6 weeks of treatment, there were significant  improvement in both melasma and lentigo solaris.
背景:黄褐斑和太阳色斑是常见的、复发的、难治性的获得性色素沉着症。尽管有各种各样的治疗选择可用于这种美容毁容的条件,这种条件的治疗仍然是一个挑战。壬二酸(Azelaic acid, AA)是一种脱色剂,通过抑制DNA合成和线粒体酶,从而对黑素细胞产生直接的细胞毒性作用。乙醇酸(GA)果皮是治疗黄褐斑和黄斑最通用的药物之一。GA剥皮单独或与局部低色素剂联合已显示出令人鼓舞的结果。然而,目前还缺乏对照试验来证明GA换肤与局部AA联合使用的有效性。病例:一名42岁的街头小贩女性,自一年前开始,双颊、鼻子、下巴和前额出现深棕色斑点,并蔓延到整个脸。她有使用避孕药的历史。皮肤病学检查:上颌、左颊、颏、额部可见多处边界清晰、不规则、不对称的色素高斑,大小从透镜状到斑块状不等。我们还在右侧颧骨上发现了一个瘤状的深棕色色素沉着斑。她被诊断为黄褐斑和太阳斑。黄褐斑面积严重指数(MASI)评分为25.6分,属于中度黄褐斑。她每天涂两次20%杜鹃花酸乳霜,涂spf50的广谱防晒霜,涂20%脱皮的GA。结果:治疗6周后,黄褐斑、黄斑均有明显改善。
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引用次数: 0
Correlation of ACE Gene Polymorphism and Hypertension in Stroke Ischemic Patients 脑卒中缺血性患者ACE基因多态性与高血压的相关性研究
Pub Date : 2020-01-20 DOI: 10.32734/SUMEJ.V3I1.3310
V. Chandra, Y. Siregar, C. A. Arina
Stroke is the third highest cerebrovascular disease in the world with high mortality and disability rate that is mostly dominated by ischemic stroke. Genetic factor that had been reported to have an indirect effect in increasing the incidence of ischemic stroke is ACE gene polymorphism. ACE gene polymorphism is characterized by the insertion marked by letter (I) or deletion marked by letter (D) on intron 16, chromosome 17. ACE gene polymorphism has drawn a lot of attention from scientists and had been reported to have an indirect effect in increasing the ischemic stroke incidence through pathogenesis of hypertension and atherosclerosis. In this study, 78 subjects of ischemic stroke consist of 43 subjects with hypertension and 35 subjects with normotension. I allele of ACE gene polymorphism was more dominant than D allele in hypertensive ischemic stroke patients (72.1% > 27,9%) and this dominance was also seen in the incidence of hypertension vs normotension (55.4% > 44.6%). However, the correlation of ACE gene polymorphism with the incidence of hypertension was not statistically significant when compared based on its genotype (p=0.280) and allele (p=0.948).
中风是世界第三大脑血管疾病,死亡率和致残率高,主要以缺血性中风为主。已报道的增加缺血性脑卒中发病率的间接影响的遗传因素是ACE基因多态性。ACE基因多态性以17号染色体16号内含子上以字母(I)标记的插入或以字母(D)标记的缺失为特征。ACE基因多态性引起了科学家们的广泛关注,有报道称其通过高血压和动脉粥样硬化的发病机制间接增加了缺血性脑卒中的发病率。本研究共78例缺血性脑卒中患者,其中高血压患者43例,血压正常者35例。ACE基因多态性I等位基因在高血压缺血性脑卒中患者中比D等位基因更占优势(72.1% > 27.9%),这种优势在高血压与正常血压的发生率中也存在(55.4% > 44.6%)。然而,从ACE基因型(p=0.280)和等位基因(p=0.948)比较,ACE基因多态性与高血压发病率的相关性无统计学意义。
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引用次数: 1
The Association Between Skin Types and Acne Vulgaris 皮肤类型与寻常性痤疮之间的关系
Pub Date : 2020-01-20 DOI: 10.32734/SUMEJ.V3I1.3279
A. Tamba, N. Jusuf
The skin problem often found on adolescents is acne vulgaris. The pathogenesis of acne vulgaris is multifactorial, from increased production of sebum, hyperproliferation of pilosebaceous follicles, colonization of Cutibacterium acnes, to inflammation process. The elevated sebum production which is often linked to oily skin type could result in acne vulgaris in adolescents. According to Baumann Skin Type, one of the parameters in categorizing skin type is having either oily or dry skin. Acne vulgaris is also found on dry skin. This research aims to find the association between skin types and acne  vulgaris. It is an analitic research with cross-sectional method. The data were acquired from 93 students of SMA Santo Thomas 1 Medan who fulfilled the inclusion criteria with stratified random sampling method. The collection of data were primarily carried out with dermatology examination and Baumann Skin Type questionnaire to determine the skin types. Then, they were analyzed with Chi-square test to see the relationship between skin types and acne vulgaris.      The obtained results show that 73 (78,5%) out of 93 students suffered from acne vulgaris with predominance being female (39,8%) than male (38,7%), and those in 15-year age group (38,7%). The most commonly observed skin type on samples is oily skin (79,6%). The bivariate analysis with acquired p-value of 0,002 (p<0,05) led to a conclusion that there is a significant association between skin types and acne vulgaris.
在青少年身上经常发现的皮肤问题是寻常痤疮。寻常痤疮的发病机制是多因素的,从皮脂分泌增加、毛囊皮脂腺增生、痤疮表皮杆菌的定植到炎症过程。通常与油性皮肤类型有关的皮脂产量升高可能导致青少年患上寻常性痤疮。根据鲍曼皮肤类型,分类皮肤类型的参数之一是油性或干性皮肤。干性皮肤上也会出现寻常性痤疮。本研究旨在发现皮肤类型与寻常性痤疮之间的关系。采用横断面分析方法进行分析研究。采用分层随机抽样方法,对93名符合纳入标准的棉兰圣托马斯小学学生进行数据采集。数据收集主要通过皮肤病学检查和鲍曼皮肤类型问卷来确定皮肤类型。然后用卡方检验分析皮肤类型与寻常性痤疮的关系。结果显示,93名学生中有73人(78.5%)患有寻常性痤疮,其中女性(39.8%)多于男性(38.7%),15岁年龄组(38.7%)居多。样本中最常见的皮肤类型是油性皮肤(79.6%)。双变量分析获得的p值为0.002 (p< 0.05),得出皮肤类型与寻常痤疮之间存在显著关联的结论。
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引用次数: 1
Risk Factors Analysis of Premature Canities in Medical Students of Universitas Sumatera Utara Class 2016-2018 苏门答腊北上大学2016-2018级医学生早产危险因素分析
Pub Date : 2020-01-20 DOI: 10.32734/SUMEJ.V3I1.3543
Eka Zhaki Safira Lubis, N. Jusuf
Abstract. Background. Premature canities is a terminology to describe a premature graying of hair before the age of 25 in Asians.The ethiopathogenesis of premature canities is still not fully understood, but there are risk factors associated to premature canities such as gender, family history, obesity, smoking, alcohol consumption, other disease, micronutrients deficiencies. Aims: to evaluate risk  factors that influence the incidence of premature canities in medical students of University of Sumatera Utara class 2016-2018. Methods: This research is an analytic research with the number of subjects are  80 respondents using bivariate and multivariate analysis using logistic regression test. Results: of the 80 respondents, 57 respondents (71,2%) had premature canities. Based on bivariate analysis, it was obtained p value ≤ 0,05 for family history and stress, Based on multiavariate analysis, it was obtained p value ≤ 0,05 for family history (p value = 0,000), which means family history is the most dominants factors for premature canities. Conclusion: there is a correlation between premature canities and family history and stress and Family history is the most dominant risk factors that associated to premature canities in medical students of University of Sumatera Utara class 2016-2018. 
摘要背景。早老性龋齿是一个术语,用来描述亚洲人在25岁之前头发过早变白。龋齿的埃塞俄比亚发病机制尚不完全清楚,但存在与龋齿有关的风险因素,如性别、家族史、肥胖、吸烟、饮酒、其他疾病、微量营养素缺乏。目的:探讨影响2016-2018级苏门答腊北方大学医学生早发性龋齿发病率的危险因素。方法:本研究为分析性研究,调查对象80人,采用logistic回归检验进行双因素和多因素分析。结果:80名调查对象中,有57名(71.2%)存在龋早。基于双变量分析,家族史和压力的p值≤0.05,基于多变量分析,家族史的p值≤0.05 (p值= 0000),说明家族史是导致早产的最主要因素。结论:在2016-2018级苏门答腊北原大学医学生中,家族史与患牙过早存在相关性,家族史是与患牙过早相关的最主要危险因素。
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引用次数: 1
Description Of Bag Load With Antropometry Of Elementary School Students 小学生负重负重负重测量表的描述
Pub Date : 2020-01-20 DOI: 10.32734/sumej.v3i1.3336
Priya Darshini Krishna Moorthi, Y. Machrina, L. I. Laksmi, M. R. Yaznil
Background. Low back pain is one of the most common health problem among school students. Carrying heavy backpack to school is one of the cause of low back pain. Objectives. To identify the bag load carried by the students and antropometry of the students. Method. This research is a descriptive observasional with cross sectional method. Data used is a primer data which is from 268 students by measuring their body weight, height, bag weight and also by interviewing them using interview guidelines. Results. The results obtained from 268 elememtary school students of Siti Hajar mostly have normal nutritional status. The average bag weight at level I (6.071%), level II (8.510%) and level III (10.812%) where the majority of bag loads compared to elementary school antropometry were included in the mild category 47.6% at level I, 74.7% at level II and 84.3% at level III eventhough there were some children in the heavy category. 88.8% of children carry their school bags using two shoulders, with a duration of time <30 minutes (61.7%). Respondents who experienced back pain (4.9%) and who did not experience back pain (95.1%). Conclusions. The weight of Siti Hajar Elementary School children bag against antropometry has not exceeded the recommended load limit. Key words. Bag load, antropometry, cross-sectional, interview
背景。腰痛是在校学生中最常见的健康问题之一。背沉重的书包上学是腰痛的原因之一。目标。确定学生的负重情况和学生的负重情况。方法。本研究采用横断面法进行描述性观察。使用的数据是来自268名学生的初级数据,通过测量他们的体重,身高,书包重量,并使用访谈指南对他们进行访谈。结果。结果显示,西提哈贾尔县268名小学生营养状况基本正常。与小学测压相比,大部分儿童的平均袋重在一级(6.071%)、二级(8.510%)和三级(10.812%),其中一级(47.6%)为轻度,二级(74.7%)为轻度,三级(84.3%)为重度,尽管有部分儿童属于重度。88.8%的孩子用双肩背书包,持续时间<30分钟(61.7%)。有背痛经历的受访者(4.9%)和没有背痛经历的受访者(95.1%)。结论。Siti Hajar小学儿童抗压袋重量未超过推荐负荷限制。关键字。袋装,气压计,横断面,访谈
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引用次数: 0
Adherence to European Society of Cardiology Heart Failure Treatment Guideline in Haji Adam Malik General Hospital Medan 棉兰哈吉亚当马利克综合医院遵守欧洲心脏病学会心力衰竭治疗指南
Pub Date : 2020-01-20 DOI: 10.32734/SUMEJ.V3I1.3382
Ardy Putra Wirtanto, A. Sitepu
Background. Heart failure is a public health problem and the main cause of morbidity and mortality in the world. The goal of the therapy is to reduce symptoms, prevents rehospitalization and increases survivability. Objective. To evaluate the adherence to the European Society of Cardiology for heart failure treatment at H. Adam Malik Medan hospital. Methods. The study was descriptive observational cross sectional design with medical record data of heart failure at H. Adam Malik Hospital, using consecutive sampling method. The adherence of guidelines was assessed by: (1) drug prescribing (“yes” or “no”), and (2) guideline adherence indicator (GAI), both GAI-3 or GAI-5, by calculating the proportion as the number of drugs prescribed by number of drugs indicated to the ESC guidelines. Results. From research, the predominant GAI-3 and GAI-5 were High, which were 54.9% and 59.5%, respectively. The recommended drug used based on indications were ACE-i / ARB (89.1%), beta-blockers (83.4%), MRA (73.6%), diuretics (93.7%), and digitalis (20,8%). Conclusion. The predominant category in adherence to the ESC heart failure treatment guidelines based on GAI-3 and GAI-5 is High.
背景。心力衰竭是一个公共卫生问题,也是世界上发病率和死亡率的主要原因。治疗的目标是减轻症状,防止再次住院,提高生存率。目标。评估欧洲心脏病学会对H. Adam Malik Medan医院心力衰竭治疗的依从性。方法。本研究采用描述性观察横断面设计,采用连续抽样方法,选取H. Adam Malik医院心力衰竭患者的病历资料。指南的依从性通过(1)药物处方(“是”或“否”)和(2)指南依从性指标(GAI), GAI-3或GAI-5,通过计算ESC指南指示的药物数量与处方药物数量的比例来评估。结果。研究结果表明,优势基因为GAI-3和GAI-5,分别占54.9%和59.5%。根据适应症推荐使用的药物是ACE-i / ARB(89.1%)、β受体阻滞剂(83.4%)、MRA(73.6%)、利尿剂(93.7%)和洋地黄(20.8%)。结论。遵循基于GAI-3和GAI-5的ESC心力衰竭治疗指南的主要类别是高。
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引用次数: 0
The Correlation Between Body Mass Index And Acne Vulgaris 体质指数与寻常性痤疮的相关性研究
Pub Date : 2020-01-20 DOI: 10.32734/SUMEJ.V3I1.3557
Ghinia Zati Hulwani Raditra, M. I. Sari
Skin diseases for teenagers and young adults are acne vulgaris. It occurs through various factors, such as food and obesity. Foods with a high glycemic index (IG) are associated with a high incidence of acne vulgaris. By considering the Body Mass Index, the glycemic load has a significant relationship with the occurrence of acne vulgaris. The relationship between BMI and acne vulgaris in the class of 2016 FK USU student population. This study was analytic design with cross sectional design, a sample by 2016 FK USU students. Data collected by conducting a physical examination, measurement of height, weight, determination of BMI, and nutrient intake using the Food Frequency Questioner (FFQ) questionnaire. Data is collected using SPSS program. Then, a Chi-Square test was performed. The incidence of acne vulgaris in students 2016 FK USU was 46.1%. With majority of locations arising acne vulgaris is in the face of 35.6%. The most common age suffering from acne vulgaris is 21 years (22.2%). Women (30.6%) from acne vulgaris than men (15.6%). The most BMI in the sample is underweight to normal body weight (31.7%). The results of data analysis, found no relationship between BMI and acne vulgaris p = 0.336
青少年和年轻人的皮肤病是寻常痤疮。它通过各种因素发生,比如食物和肥胖。高血糖指数(IG)的食物与寻常痤疮的高发有关。结合体质指数,血糖负荷与寻常痤疮的发生有显著关系。2016年FK USU学生体重指数与寻常痤疮的关系本研究采用横断面设计的分析设计,样本为2016年FK USU学生。收集的数据通过进行身体检查,测量身高,体重,确定BMI,并使用食物频率问卷(FFQ)营养摄入。使用SPSS程序收集数据。然后进行卡方检验。2016年FK USU学生中寻常性痤疮的发生率为46.1%。寻常性痤疮的发生部位以面部居多,占35.6%。寻常性痤疮最常见的发病年龄为21岁(22.2%)。女性(30.6%)患寻常性痤疮多于男性(15.6%)。样本中体重指数最高的是体重过轻至正常体重(31.7%)。数据分析结果显示,BMI与寻常性痤疮无相关性p = 0.336
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引用次数: 0
Relationship Between CHA2DS2-VASC Score With CIN For AMI Patients After PCI AMI患者PCI术后CHA2DS2-VASC评分与CIN的关系
Pub Date : 2019-10-17 DOI: 10.32734/sumej.v2i3.1294
Herman Wiliam Parlindungan
The CHA2DS2-VASC score has been reported recently to predict adverse clinical outcomes so is CIN in patients with AMI regardless of having AF. We investigated relationship between CHA2DS2-VASC score with CIN in patients who underwent PCI strategies. This is a study of 40 patients with and underwent PCI. The CHA2DS2-VASC score was calculated for each patient. From this study 16 cases(18.82%) of CIN were diagnosed. CIN was defined as rise in serum creatinine>0,5mg/dL or>25% increase in baseline within 24h after PCI. In the ROC curve analysis,the cut-off value of CHA2DS2-VASC score in the prediction of CIN was>4(sensitivity:56.25%,Specificity:87.5%)(AUC0.698,95%:CI1.460-6.163,p=0.003) and has a significant association with CIN(R20.485). We also identified Hb level<12mg/dL as an independent predictor of CIN with (RR3.44,95%:CI1.816-6.532,p<0.001). The CHA2DS2-VASC score was positively associated with CIN. Therefore,it can be used as a simple and reliable tools to predict CIN in AMI patients who underwent PCI.
最近有报道称CHA2DS2-VASC评分可以预测不良临床结果,AMI患者的CIN也可以预测不良临床结果,无论是否患有房颤。我们研究了接受PCI治疗的患者CHA2DS2-VASC评分与CIN之间的关系。这是一项针对40名接受PCI治疗的患者的研究。计算每位患者的CHA2DS2-VASC评分。本组共确诊16例(18.82%)CIN。CIN定义为PCI术后24小时内血清肌酐>升高0、5mg/dL或>基线升高25%。在ROC曲线分析中,CHA2DS2-VASC评分预测CIN的临界值为bb0.4(敏感性56.25%,特异性87.5%)(AUC0.698,95%:CI1.460-6.163,p=0.003),与CIN有显著相关性(R20.485)。我们还发现Hb水平<12mg/dL是CIN的独立预测因子(RR3.44,95%:CI1.816-6.532,p<0.001)。CHA2DS2-VASC评分与CIN呈正相关。因此,它可以作为一种简单可靠的预测AMI患者行PCI后CIN的工具。
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引用次数: 0
Management of Congenital Aural Atresia : A Case Report 先天性耳闭锁的治疗1例报告
Pub Date : 2019-09-30 DOI: 10.32734/sumej.v2i3.1263
Yuli Tetriana Sari, Delfitri Munir
Congenital Aural Atresia (CAA) is the failure of development of the external auditory canal. It usually occurs in conjunction with microtia, which is malformation of the auricle due to the failure of development of the external ear. The evaluation and treatment of aural atresia present a number of challenges to the otologic surgeon. Computed tomography also plays a pivotal role in planning the surgery and grading the outcome of the surgery in congenital aural atresia. We report a case of unilateral congenital aural atresia and microtia and did a canalplasty and tympanoplasty in this patient.
先天性耳闭锁是指外耳道发育不全。它通常与小耳畸形一起发生,小耳畸形是由于外耳发育失败导致的耳廓畸形。耳闭锁的评估和治疗对耳外科医生提出了许多挑战。计算机断层扫描在先天性耳闭锁的手术计划和手术结果分级中也起着关键作用。我们报告一例单侧先天性耳闭锁和小耳症,并对该患者进行了耳管成形术和鼓室成形术。
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引用次数: 0
期刊
Sumatera Medical Journal
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