Pub Date : 1996-03-01DOI: 10.1128/MMBR.60.1.167-215.1996
C. Sears, J. Kaper
s of the 86th Annual Meeting of the American Society for Microbiology 1986. American Society for Microbiology, Washington, D.C. 496. Shapiro, M., J. Matthews, G. Hecht, C. Delp, and J. L. Madara. 1991. Stabilization of F-actin prevents cAMP-elicited Cl secretion in T84 cells. J. Clin. Invest. 87:1903–1909. 497. Shinagawa, K., S. Ueno, H. Konuma, N. Matsusaka, and S. Sugii. 1991. Purification and characterization of the vascular permeability factor pro- duced by Bacillus cereus. J. Vet. Med. Sci. 53:281–286. 498. Shinoda, S., H. Matsuoka, T. Tsuchie, S.-I. Miyoshi, S. Yamamoto, H. Taniguchi, and Y. Mizuguchi. 1991. Purification and characterization of a lecithin-dependent haemolysin from Escherichia coli transformed by a Vibrio parahaemolyticus gene. J. Gen. Microbiol. 137:2705–2711. 499. Shirai, H., H. Ito, T. Hirayama, Y. Nakamoto, N. Nakabayashi, K. Kuma- gai, Y. Takeda, and M. Nishibuchi. 1990. Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis. Infect. Immun. 58:3568–3573. 500. Silva, T. M. J., C. O. Tacket, J. B. Kaper, M. Schleupner, and R. L. Guerrant. New evidence for an inflammatory component in El Tor and O139 cholera and in diarrhea caused by selected new live attenuated chol- era vaccines. Submitted for publication. 501. Singh, D. V., and S. C. Sanyal. 1992. Production of haemolysis and its correlation with enterotoxicity in Aeromonas spp. J. Med. Microbiol. 37: 262–267. 502. Sjogren, R., R. Neill, D. Rachmilewitz, D. Fritz, J. Newland, D. Sharpnack, C. Colleton, J. Fondacaro, P. Gemski, and E. Boedeker. 1994. Role of Shiga-like toxin I in bacterial enteritis: comparison between isogenic Esch- erichia coli strains induced in rabbits. Gastroenterology 106:306–317. 503. Sjogren, R. W., P. M. Sherman, and E. C. Boedeker. 1989. Altered intestinal motility precedes diarrhea during Escherichia coli enteric infection. Am. J. Physiol. 257:G725–G731. 504. Skjelkvale, R., and C. L. Duncan. 1975. Enterotoxin formation by different toxigenic types of Clostridium perfringens. Infect. Immun. 11:563–575. 505. Skjelkvale, R., and C. L. Duncan. 1975. Characterization of enterotoxin VOL. 60, 1996 ENTERIC BACTERIAL TOXINS AND INTESTINAL SECRETION 213
1986年第86届美国微生物学会年会上的主席。美国微生物学会,华盛顿特区496。夏皮罗、J.马修斯、G.赫赫特、C.德尔普和J. L.马达拉。1991。稳定f -肌动蛋白可阻止camp诱导的T84细胞Cl分泌。j .中国。投资。87:1903 - 1909。497. 品川K、上野s、小沼h、松坂n、杉井S. 1991。蜡样芽孢杆菌血管通透性因子的纯化及特性研究。j .兽医。医学科学。53:281-286。498. Shinoda, S, H. Matsuoka, T. Tsuchie, S. i。Miyoshi, S. Yamamoto, H. Taniguchi和Y. Mizuguchi. 1991。由副溶血性弧菌基因转化的大肠杆菌卵磷脂依赖性溶血素的纯化和鉴定。中华微生物学杂志,37(7):557 - 557。499. 白井,H., H. Ito, T.平山,Y. Nakamoto, N. Nakabayashi, K. Kuma- gai, Y. Takeda,和M. Nishibuchi. 1990。副溶血性弧菌热稳定性直接溶血素(TDH)及TDH相关溶血素与胃肠炎相关的分子流行病学证据。感染。Immun 58:3568 - 3573。500. 席尔瓦,t.m.j., c.o.塔克特,j.b.k aper, M. Schleupner和R. L. Guerrant。新证据表明El - Tor和O139霍乱以及选定的新型减毒霍乱活疫苗引起的腹泻中存在炎症成分。已提交出版。501. 辛格,D. V.和S. C. Sanyal. 1992。[j] .中华微生物学杂志,2001,19(3):326 - 326。502. Sjogren, R. Neill, D. rachmilwitz, D. Fritz, J. Newland, D. Sharpnack, C. Colleton, J. Fondacaro, P. Gemski和E. Boedeker. 1994。志贺样毒素I在细菌性肠炎中的作用:家兔诱导的等基因大肠埃希菌的比较。胃肠病学106:306 - 317。503. 肖格伦,r.w., P. M. Sherman和E. C. Boedeker, 1989。大肠杆菌肠道感染期间,肠道蠕动改变先于腹泻。点。[j] .中国生物医学工程学报,2016(5):559 - 561。504. R. Skjelkvale和C. L. Duncan, 1975。产气荚膜梭菌不同产毒素类型形成的肠毒素。感染。Immun 11:563 - 575。505. R. Skjelkvale和C. L. Duncan, 1975。肠道细菌毒素与肠道分泌物[j]
{"title":"Enteric bacterial toxins: mechanisms of action and linkage to intestinal secretion.","authors":"C. Sears, J. Kaper","doi":"10.1128/MMBR.60.1.167-215.1996","DOIUrl":"https://doi.org/10.1128/MMBR.60.1.167-215.1996","url":null,"abstract":"s of the 86th Annual Meeting of the American Society for Microbiology 1986. American Society for Microbiology, Washington, D.C. 496. Shapiro, M., J. Matthews, G. Hecht, C. Delp, and J. L. Madara. 1991. Stabilization of F-actin prevents cAMP-elicited Cl secretion in T84 cells. J. Clin. Invest. 87:1903–1909. 497. Shinagawa, K., S. Ueno, H. Konuma, N. Matsusaka, and S. Sugii. 1991. Purification and characterization of the vascular permeability factor pro- duced by Bacillus cereus. J. Vet. Med. Sci. 53:281–286. 498. Shinoda, S., H. Matsuoka, T. Tsuchie, S.-I. Miyoshi, S. Yamamoto, H. Taniguchi, and Y. Mizuguchi. 1991. Purification and characterization of a lecithin-dependent haemolysin from Escherichia coli transformed by a Vibrio parahaemolyticus gene. J. Gen. Microbiol. 137:2705–2711. 499. Shirai, H., H. Ito, T. Hirayama, Y. Nakamoto, N. Nakabayashi, K. Kuma- gai, Y. Takeda, and M. Nishibuchi. 1990. Molecular epidemiologic evidence for association of thermostable direct hemolysin (TDH) and TDH-related hemolysin of Vibrio parahaemolyticus with gastroenteritis. Infect. Immun. 58:3568–3573. 500. Silva, T. M. J., C. O. Tacket, J. B. Kaper, M. Schleupner, and R. L. Guerrant. New evidence for an inflammatory component in El Tor and O139 cholera and in diarrhea caused by selected new live attenuated chol- era vaccines. Submitted for publication. 501. Singh, D. V., and S. C. Sanyal. 1992. Production of haemolysis and its correlation with enterotoxicity in Aeromonas spp. J. Med. Microbiol. 37: 262–267. 502. Sjogren, R., R. Neill, D. Rachmilewitz, D. Fritz, J. Newland, D. Sharpnack, C. Colleton, J. Fondacaro, P. Gemski, and E. Boedeker. 1994. Role of Shiga-like toxin I in bacterial enteritis: comparison between isogenic Esch- erichia coli strains induced in rabbits. Gastroenterology 106:306–317. 503. Sjogren, R. W., P. M. Sherman, and E. C. Boedeker. 1989. Altered intestinal motility precedes diarrhea during Escherichia coli enteric infection. Am. J. Physiol. 257:G725–G731. 504. Skjelkvale, R., and C. L. Duncan. 1975. Enterotoxin formation by different toxigenic types of Clostridium perfringens. Infect. Immun. 11:563–575. 505. Skjelkvale, R., and C. L. Duncan. 1975. Characterization of enterotoxin VOL. 60, 1996 ENTERIC BACTERIAL TOXINS AND INTESTINAL SECRETION 213","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"10 1","pages":"167-215"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90212323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-03-01DOI: 10.1128/mr.60.1.44-69.1996
P Alifano, R Fani, P Liò, A Lazcano, M Bazzicalupo, M S Carlomagno, C B Bruni
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Università degli Studi di Napoli ‘‘Federico II,’’ I-80131 Naples, and Dipartimento di Biologia Animale e Genetica, Università degli Studi di Firenze, I-50125 Firenze, Italy, and Departamento de Biologia, Faculdad de Ciencias, Universidad Nacional Autónoma de México, Mexico 04510 D.F., Mexico
{"title":"Histidine biosynthetic pathway and genes: structure, regulation, and evolution.","authors":"P Alifano, R Fani, P Liò, A Lazcano, M Bazzicalupo, M S Carlomagno, C B Bruni","doi":"10.1128/mr.60.1.44-69.1996","DOIUrl":"https://doi.org/10.1128/mr.60.1.44-69.1996","url":null,"abstract":"Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Università degli Studi di Napoli ‘‘Federico II,’’ I-80131 Naples, and Dipartimento di Biologia Animale e Genetica, Università degli Studi di Firenze, I-50125 Firenze, Italy, and Departamento de Biologia, Faculdad de Ciencias, Universidad Nacional Autónoma de México, Mexico 04510 D.F., Mexico","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"60 1","pages":"44-69"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239417/pdf/600044.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-03-01DOI: 10.1128/mr.60.1.233-249.1996
G Caponigro, R Parker
INTRODUCTION .......................................................................................................................................................233 METHODS FOR STUDYING mRNA TURNOVER IN S. CEREVISIAE ...........................................................234 Approach to Steady-State Labeling......................................................................................................................234 Inhibition of Transcription by Using Drugs .......................................................................................................234 Inhibition of Transcription by Using a Conditional Allele of RNA Polymerase II.......................................234 Inhibition of Transcription by Using Regulated Promoters.............................................................................235 Transcriptional Pulse-Chase: a Method for Examining Pathways of Decay..................................................235 Identification of Intermediates in mRNA Decay ................................................................................................235 DETERMINANTS OF mRNA STABILITY IN S. CEREVISIAE ..........................................................................236 Specific Sequences Influence mRNA Half-Lives.................................................................................................236 Nonspecific Features of mRNAs Generally Do Not Influence mRNA Half-Lives .........................................237 There is no correlation between mRNA length and stability .......................................................................237 Ribosome protection cannot account for mRNA half-lives...........................................................................237 Rare codons are not general determinants of mRNA stability ....................................................................238 A COMMON PATHWAY OF mRNA DECAY........................................................................................................238 Deadenylation Precedes the Decay of Some Yeast mRNAs ..............................................................................238 Decapping and 5*-to-3* Exonucleolytic Digestion Follow Deadenylation of Some Yeast mRNAs...............239 Deadenylation-Dependent Decapping Is a Common Pathway of mRNA Decay ............................................239 Control of mRNA Half-Lives through the Deadenylation-Dependent Decapping Pathway .........................240 Control of mRNA deadenylation ......................................................................................................................240 (i) Poly(A)-binding protein influences deadenylation................................................................................240 (ii) Poly(A)-binding protein-dependent nuclease activity from S. cerevisiae ..........................................240 (iii) Other proteins possibly involved in deadenylation............................
{"title":"Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae.","authors":"G Caponigro, R Parker","doi":"10.1128/mr.60.1.233-249.1996","DOIUrl":"https://doi.org/10.1128/mr.60.1.233-249.1996","url":null,"abstract":"INTRODUCTION .......................................................................................................................................................233 METHODS FOR STUDYING mRNA TURNOVER IN S. CEREVISIAE ...........................................................234 Approach to Steady-State Labeling......................................................................................................................234 Inhibition of Transcription by Using Drugs .......................................................................................................234 Inhibition of Transcription by Using a Conditional Allele of RNA Polymerase II.......................................234 Inhibition of Transcription by Using Regulated Promoters.............................................................................235 Transcriptional Pulse-Chase: a Method for Examining Pathways of Decay..................................................235 Identification of Intermediates in mRNA Decay ................................................................................................235 DETERMINANTS OF mRNA STABILITY IN S. CEREVISIAE ..........................................................................236 Specific Sequences Influence mRNA Half-Lives.................................................................................................236 Nonspecific Features of mRNAs Generally Do Not Influence mRNA Half-Lives .........................................237 There is no correlation between mRNA length and stability .......................................................................237 Ribosome protection cannot account for mRNA half-lives...........................................................................237 Rare codons are not general determinants of mRNA stability ....................................................................238 A COMMON PATHWAY OF mRNA DECAY........................................................................................................238 Deadenylation Precedes the Decay of Some Yeast mRNAs ..............................................................................238 Decapping and 5*-to-3* Exonucleolytic Digestion Follow Deadenylation of Some Yeast mRNAs...............239 Deadenylation-Dependent Decapping Is a Common Pathway of mRNA Decay ............................................239 Control of mRNA Half-Lives through the Deadenylation-Dependent Decapping Pathway .........................240 Control of mRNA deadenylation ......................................................................................................................240 (i) Poly(A)-binding protein influences deadenylation................................................................................240 (ii) Poly(A)-binding protein-dependent nuclease activity from S. cerevisiae ..........................................240 (iii) Other proteins possibly involved in deadenylation............................","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"60 1","pages":"233-49"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239426/pdf/600233.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-03-01DOI: 10.1128/mr.60.1.250-265.1996
R B Wickner
INFECTIOUS ELEMENTS OF SACCHAROMYCES CEREVISIAE 250 BIOLOGY OF THE YEAST dsRNA VIRUSES AND THE KILLER PHENOMENON 250 L-A VIRUS STRUCTURE: T 5 1 WITH 60 ASYMMETRIC Gag DIMERS 251 VIRAL REPLICATION CYCLES 251 L-A ENCODES Gag AND Gag-Pol 252 REPLICATION AND TRANSCRIPTION OF VIRAL RNA: IN VITRO SYSTEMS 254 TRANSLATION OF VIRAL mRNA 254 The SKI2,3,8 System Blocks the Translation of Non-Poly(A) mRNA 255 M1 Propagation Depends Critically on Free 60S Ribosomal Subunit Levels 256 Do SKI2, 3, and 8 Determine 60S Subunit Interaction with Poly(A)? 257 Gag Makes Decapitated Decoys To Distract the SKI1/XRN1 Exoribonuclease 257 Lethality of ski1 ski2 and ski1 ski3 double mutants 258 Gag-Pol Fusion Protein Formed by a 21 Ribosomal Frameshift: How and Why 258 Mechanism of 21 ribosomal frameshifting 258 How critical is the efficiency of frameshifting? 259 Chromosomal genes affecting the efficiency of frameshifting 259 Can 21 ribosomal frameshifting be used as a target of antiviral drugs? 259 POSTTRANSLATIONAL PROCESSING 259 MAK3 N-Acetyltransferase Modification of Gag Is Necessary for Assembly 259 Killer Preprotoxin Is Processed To Form Mature Toxin 260 KEX1 and KEX2 Processing Proteases and Mammalian Prohormone Processing 260 RNA PACKAGING: IN VITRO AND IN VIVO 260 Evidence for cis Packaging by L-A 260 Does Packaging Control Translation? 260 L-BC IS CLOSELY RELATED TO L-A 261 CONCLUSIONS AND PROSPECTS 261 REFERENCES 262
{"title":"Double-stranded RNA viruses of Saccharomyces cerevisiae.","authors":"R B Wickner","doi":"10.1128/mr.60.1.250-265.1996","DOIUrl":"https://doi.org/10.1128/mr.60.1.250-265.1996","url":null,"abstract":"INFECTIOUS ELEMENTS OF SACCHAROMYCES CEREVISIAE 250 BIOLOGY OF THE YEAST dsRNA VIRUSES AND THE KILLER PHENOMENON 250 L-A VIRUS STRUCTURE: T 5 1 WITH 60 ASYMMETRIC Gag DIMERS 251 VIRAL REPLICATION CYCLES 251 L-A ENCODES Gag AND Gag-Pol 252 REPLICATION AND TRANSCRIPTION OF VIRAL RNA: IN VITRO SYSTEMS 254 TRANSLATION OF VIRAL mRNA 254 The SKI2,3,8 System Blocks the Translation of Non-Poly(A) mRNA 255 M1 Propagation Depends Critically on Free 60S Ribosomal Subunit Levels 256 Do SKI2, 3, and 8 Determine 60S Subunit Interaction with Poly(A)? 257 Gag Makes Decapitated Decoys To Distract the SKI1/XRN1 Exoribonuclease 257 Lethality of ski1 ski2 and ski1 ski3 double mutants 258 Gag-Pol Fusion Protein Formed by a 21 Ribosomal Frameshift: How and Why 258 Mechanism of 21 ribosomal frameshifting 258 How critical is the efficiency of frameshifting? 259 Chromosomal genes affecting the efficiency of frameshifting 259 Can 21 ribosomal frameshifting be used as a target of antiviral drugs? 259 POSTTRANSLATIONAL PROCESSING 259 MAK3 N-Acetyltransferase Modification of Gag Is Necessary for Assembly 259 Killer Preprotoxin Is Processed To Form Mature Toxin 260 KEX1 and KEX2 Processing Proteases and Mammalian Prohormone Processing 260 RNA PACKAGING: IN VITRO AND IN VIVO 260 Evidence for cis Packaging by L-A 260 Does Packaging Control Translation? 260 L-BC IS CLOSELY RELATED TO L-A 261 CONCLUSIONS AND PROSPECTS 261 REFERENCES 262","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"60 1","pages":"250-65"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239427/pdf/600250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-03-01DOI: 10.1128/mr.60.1.1-20.1996
M L Greenberg, J M Lopes
{"title":"Genetic regulation of phospholipid biosynthesis in Saccharomyces cerevisiae.","authors":"M L Greenberg, J M Lopes","doi":"10.1128/mr.60.1.1-20.1996","DOIUrl":"https://doi.org/10.1128/mr.60.1.1-20.1996","url":null,"abstract":"","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"60 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC239415/pdf/600001.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19821014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-03-01DOI: 10.1128/MMBR.60.1.44-69.1996
P. Alifano, R. Fani, P. Lio’, A. Lazcano, M. Bazzicalupo, M. Carlomagno, C. Bruni
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Universita degli Studi di Napoli ‘‘Federico II,’’ I-80131 Naples, and Dipartimento di Biologia Animale e Genetica, Universita degli Studi di Firenze, I-50125 Firenze, Italy, and Departamento de Biologia, Faculdad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico 04510 D.F., Mexico
{"title":"Histidine biosynthetic pathway and genes: structure, regulation, and evolution.","authors":"P. Alifano, R. Fani, P. Lio’, A. Lazcano, M. Bazzicalupo, M. Carlomagno, C. Bruni","doi":"10.1128/MMBR.60.1.44-69.1996","DOIUrl":"https://doi.org/10.1128/MMBR.60.1.44-69.1996","url":null,"abstract":"Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare ‘‘L. Califano,’’ Universita degli Studi di Napoli ‘‘Federico II,’’ I-80131 Naples, and Dipartimento di Biologia Animale e Genetica, Universita degli Studi di Firenze, I-50125 Firenze, Italy, and Departamento de Biologia, Faculdad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico 04510 D.F., Mexico","PeriodicalId":18499,"journal":{"name":"Microbiological reviews","volume":"30 1","pages":"44-69"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83598501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}