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A Whole-Body Exercise Test to Assess Cardiorespiratory Fitness Across the Stroke Recovery Continuum. 卒中恢复连续体中评估心肺健康的全身运动试验。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003927
Kevin Moncion,Lynden Rodrigues,Bernat De Las Heras,Elise Wiley,Kira Sikorska,Jacopo Cristini,Elric Y Allison,Janice Eng,Ada Tang,Marc Roig
BACKGROUNDAccurate assessment of cardiorespiratory fitness is a critical component of cardiopulmonary exercise testing (CPET) and prescription for people with stroke. However, post-stroke disability and neuromuscular impairments are common and may disproportionately affect females throughout the continuum of recovery. There is a need to evaluate alternative whole-body CPET protocols and to characterize the sex-specific CPET responses throughout the continuum of stroke recovery.PURPOSETo characterize the sex-specific CPET responses on a whole-body recumbent stepper CPET using American College of Sports Medicine (ACSM) criteria in people with subacute (7-90 days) and chronic (≥6-60 months) stroke.METHODSParticipants underwent a whole-body recumbent stepper symptom-limited CPET. Each CPET was assessed for ventilatory threshold (VT), peak oxygen uptake (V̇O2peak) and ACSM maximal oxygen uptake V̇O2max criteria including respiratory exchange ratio [RER] ≥1.10; V̇O2 plateau, heart rate [HR] within 10 beats of HRmax, and ratings of perceived exertion [RPE] ≥17/20 or ≥7/10. Sex differences by stroke chronicity were evaluated via ttests, ranksum tests, Chi-squared, or Fisher's exact tests.RESULTSIn total, 145 participants underwent a symptom limited CPET. In subacute stroke (n=69), no sex differences were found for VT or V̇O2peak (p>0.05), but females were more likely to achieve a V̇O2 plateau (p=0.002). In chronic stroke (n=76), no sex differences were observed for VT or V̇O2max criteria (p>0.05), but females had lower V̇O2peak (p=0.002). Irrespective of sex, achieving the RPE (n=41 subacute [61%], n=38 chronic [54%]) or RER criteria (n=28 subacute [41%], n=39 [51%]) were the most commonly met ACSM criteria.CONCLUSIONSThis whole-body CPET protocol is appropriate for eliciting peak and maximal efforts in people post-stroke, however, clinicians should consider biological sex and stroke chronicity.
背景:准确评估心肺功能是心肺运动试验(CPET)和卒中患者处方的关键组成部分。然而,中风后残疾和神经肌肉损伤是常见的,并可能在整个恢复过程中不成比例地影响女性。有必要评估其他全身CPET方案,并在卒中恢复的连续过程中描述性别特异性CPET反应。目的:采用美国运动医学学院(ACSM)的标准,对亚急性(7-90天)和慢性(≥6-60个月)脑卒中患者进行全身卧位步进式CPET测试,以表征性别特异性CPET反应。方法对参与者进行了全身卧位步进症状受限的CPET检查。评估各CPET通气阈值(VT)、峰值摄氧量(V * O2peak)和ACSM最大摄氧量V * O2max标准,包括呼吸交换比[RER]≥1.10;V / O2平台,HRmax 10次内心率[HR],感知运动评分[RPE]≥17/20或≥7/10。脑卒中慢性性的性别差异通过检验、秩和检验、卡方检验或Fisher精确检验来评估。结果共有145名参与者接受了症状限制性CPET。在亚急性脑卒中(n=69)中,VT和V O2峰值无性别差异(p < 0.05),但女性更容易达到V O2平台(p=0.002)。在慢性脑卒中(n=76)患者中,VT和vo2max指标无性别差异(p < 0.05),但女性的vo2peak较低(p=0.002)。不论性别,达到RPE (n=41亚急性[61%],n=38慢性[54%])或RER标准(n=28亚急性[41%],n=39[51%])是最常见的ACSM标准。结论全身CPET方案适用于脑卒中后患者的峰值和最大努力,但临床医生应考虑生理性别和脑卒中的慢性性。
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引用次数: 0
Improved Glycemic Control in Adults with Type 2 Diabetes is More Strongly Associated with Exercise Duration Than with Volume, Frequency, or Consistency. 成人2型糖尿病患者血糖控制的改善与运动时间的关系比与运动量、运动频率或运动强度的关系更强。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003922
J L Low,K Hesketh,K Falkenhain,M E Jung,J Singer,C A Jones,C Russon,M Cocks,A McManus,J P Little,
PURPOSEExercise interventions play a pivotal role in managing type 2 diabetes (T2D), yielding significant benefits in glycemic control. Despite the recognized role of exercise duration, volume, frequency, and consistency, the literature remains discrepant on which exerts the greatest effect. The purpose of this secondary analysis was to determine the relationship between exercise duration, volume, frequency, and consistency and markers of glycemic control [HbA1c and continuous glucose monitoring (CGM) metrics] following a 26-week mHealth intervention.METHODSInactive adults with newly diagnosed (<2 years) T2D (n = 58) completed blood and 14-day CGM testing before and after a 26-week personalized exercise intervention. Raw exercise data from fitness watches were extracted for each session. Duration, volume, frequency, and consistency were calculated for the full intervention and for the first 13 weeks (greater support) and last 13 weeks (reduced support).RESULTSAverage session duration (57 ± 36 minutes) significantly predicted HbA1c (β = -0.23 (0.07), P = 0.002), 24-hour mean glucose (β = -0.03 (0.01), P = 0.01), and glycemic variability (SD; β = -0.01 (0.0), P = 0.003; Beta coefficients are reported with standard errors). Total exercise time during the first 13 weeks (2931 ± 3362 minutes) also predicted HbA1c (β = -0.001 (0.0), P = 0.01), mean glucose (β = -0.002 (0.0), P = 0.01), and glycemic variability (β = -0.005 (0.0), P = 0.03). No other exercise metrics significantly predicted outcomes.CONCLUSIONSAverage session duration and exercise time accumulated early in the intervention were the only significant predictors of improvements in HbA1c, mean glucose, and glucose variability. These findings suggest that promoting increased exercise duration, independent of type or intensity, may improve glycemic control among individuals with newly diagnosed T2D.TRIAL REGISTRATIONClinicalTrials.gov NCT04653532.
目的:运动干预在治疗2型糖尿病(T2D)中发挥关键作用,对血糖控制有显著益处。尽管人们认识到运动时间、运动量、频率和一致性的作用,但关于哪一种影响最大,文献仍然存在分歧。这项二级分析的目的是确定在26周的移动健康干预后,运动时间、运动量、频率和一致性与血糖控制指标[HbA1c和连续血糖监测(CGM)指标]之间的关系。方法新诊断(<2年)t2dm的不活动成人(n = 58)在26周个性化运动干预前后完成了血液和14天CGM检测。从健身手表中提取了每次锻炼的原始数据。计算全面干预、前13周(更大支持)和后13周(减少支持)的持续时间、数量、频率和一致性。结果平均疗程(57±36分钟)对HbA1c (β = -0.23 (0.07), P = 0.002)、24小时平均血糖(β = -0.03 (0.01), P = 0.01)、血糖变异性(SD, β = -0.01 (0.0), P = 0.003;贝塔系数用标准误差报告)。前13周的总运动时间(2931±3362分钟)也可预测HbA1c (β = -0.001 (0.0), P = 0.01),平均葡萄糖(β = -0.002 (0.0), P = 0.01)和血糖变异性(β = -0.005 (0.0), P = 0.03)。没有其他运动指标能显著预测结果。结论:干预早期累积的平均疗程和运动时间是HbA1c、平均葡萄糖和葡萄糖变异性改善的唯一显著预测因素。这些发现表明,促进增加运动时间,与类型或强度无关,可能改善新诊断的t2dm患者的血糖控制。临床试验注册。gov NCT04653532。
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引用次数: 0
Acute Severe Hypoxia Impacts Whole-body Fat Oxidation and Muscle Desaturation Kinetics During Exercise: Intensity Matters. 急性严重缺氧影响运动期间全身脂肪氧化和肌肉去饱和动力学:强度问题。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003919
Johan Garcia,Paul Allender,Davide Malatesta
PURPOSEThe aim of this study was to investigate the effects of acute exposure to severe normobaric hypoxia vs. normoxia on whole-body fat oxidation and muscle desaturation kinetics over a wide range of identical relative and absolute intensities.METHODSThirteen active men performed i) two maximal incremental tests to determine maximal oxygen uptake (V̇O2peak) in normobaric hypoxia [FiO2=13.2%, 3740 m] and normoxia [FiO2=20.7%, 375 m], and ii) two submaximal graded tests, after overnight fasting, to assess fat oxidation and muscle desaturation kinetics as a function of exercise intensity in each condition. Fat oxidation kinetics were measured using indirect calorimetry and characterized using a sinusoidal model. Vastus lateralis desaturation kinetics were measured using near-infrared spectroscopy and the tissue saturation index (TSI), and modeled through a double linear model.RESULTSCompared with the relative (%V̇O2peak) or absolute (%V̇O2peak,nomoxia) exercise intensity, absolute fat oxidation rates (g·min-1) were significantly higher in hypoxia than in normoxia, ranging from 55 to 85 %V̇O2peak (p≤0.023) and from 35 to 60 %V̇O2peak,normoxia (p≤0.027), respectively. The TSI was lower in hypoxia than in normoxia when compared at relative or absolute exercise intensity (p≤0.004), and muscle desaturation reached a maximal level only in hypoxia at high exercise intensity (p≤0.014).CONCLUSIONSCompared with normoxia, acute exposure to severe normobaric hypoxia enhanced fat oxidation pathways during moderate-to-high relative and low-to-moderate absolute exercise intensities while allowing greater and maximal muscle desaturation. These findings highlight the relevance of considering both relative and absolute intensities when comparing fat oxidation during exercise in hypoxia and normoxia and suggest that maximal muscle desaturation is not a limiting factor for fat oxidation during exercise.
目的:本研究的目的是研究急性暴露于严重的常压缺氧和常压缺氧对全身脂肪氧化和肌肉去饱和动力学在大范围内相同的相对和绝对强度的影响。方法13名积极运动的男性进行了1)两个最大增量试验,以确定在常氧缺氧[FiO2=13.2%, 3740 m]和常氧缺氧[FiO2=20.7%, 375 m]下的最大摄氧量(V²峰值);2)两个亚最大分级试验,在禁食过夜后,评估脂肪氧化和肌肉去饱和动力学在每一种情况下作为运动强度的函数。脂肪氧化动力学测量使用间接量热法和表征使用正弦模型。利用近红外光谱和组织饱和指数(TSI)测量股外侧肌去饱和动力学,并通过双线性模型建立模型。结果低氧组的绝对脂肪氧化率(g·min-1)明显高于无氧组的相对运动强度(%V氧峰值)和绝对运动强度(%V氧峰值,无氧),分别为55 ~ 85% V氧峰值(p≤0.023)和35 ~ 60% V氧峰值(p≤0.027)。相对运动强度和绝对运动强度下,低氧组TSI均低于常氧组(p≤0.004),肌肉去饱和只有在高运动强度缺氧时才达到最大水平(p≤0.014)。结论与常氧相比,急性暴露于严重常氧下,在中至高相对强度和低至中等绝对强度运动中,脂肪氧化途径增强,同时允许更大和最大的肌肉去饱和。这些发现强调了在比较低氧和常氧运动中脂肪氧化时考虑相对强度和绝对强度的相关性,并表明最大肌肉去饱和度并不是运动中脂肪氧化的限制因素。
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引用次数: 0
Sex-specific Lean Mass Changes during Marine Corps Officer Candidates School and Associations with Physical Health, Performance and Military Readiness. 海军陆战队军官候选人学校期间性别特异性瘦质量变化及其与身体健康、表现和军事准备的关系
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003918
Kristen J Koltun,Jennifer N Forse,Evan D Feigel,Dakota Tiede,Chris K Kargl,Elizabeth J Steele,Matthew B Bird,Mita Lovalekar,Brian J Martin,Bradley C Nindl
PURPOSEThis investigation compared changes in body composition between sexes during Marine Corps Officer Candidates School (OCS), and explored potential associations with physical health, performance, and military readiness outcomes.METHODSAt the onset of training, 55 officer candidates (n=27 female) completed body composition analyses and 28 (n=11 female) completed post-testing. Two way mixed measures ANOVAs compared changes over time between sexes and Pearson or Spearman's correlations examined associations among changes in body composition and performance outcomes.RESULTSFollowing training, lean mass (p=0.002, 7%) increased in female but not male candidates. Body fat percentage (p=0.013) decreased to a greater extent in female (p<0.001, -33%) than in male (p<0.001, -26%) candidates. Reductions in body mass and fat mass were similar between sexes. Change in body mass was negatively associated with change in physical fitness test score (p=0.038, r=-0.401), such that greater reductions in body mass would be associated with greater improvements in test score. Positive associations between change in body mass, BMI, and lean mass (p≤0.040, r≥0.414) with change in countermovement jump absolute force were observed. Increased lean mass was associated with reduced CRP concentration (p=0.004, ρ=-0.675).CONCLUSIONSReductions in fat mass and body mass as well as sex-specific changes in lean mass were demonstrated. Lean mass may also be beneficial for maintaining physical performance and health during military training.
目的:本研究比较了海军陆战队军官候选人学校(OCS)期间男女身体组成的变化,并探讨了身体健康、表现和军事准备结果之间的潜在联系。方法在培训开始时,55名警官候选人(n=27名女性)完成了身体成分分析,28名(n=11名女性)完成了事后测试。双向混合测量ANOVAs比较了性别之间随时间的变化,Pearson或Spearman相关性检查了身体成分变化与表现结果之间的关系。结果训练后,女性候选人的瘦质量增加(p= 0.002.7%),而男性候选人没有增加(p= 0.007%)。女性候选人体脂率(p<0.001, -33%)比男性候选人体脂率(p<0.001, -26%)下降的幅度更大。身体质量和脂肪量的减少在两性之间是相似的。体重的变化与体能测试分数的变化呈负相关(p=0.038, r=-0.401),因此体重的减少与测试分数的提高有关。体重、BMI和瘦体重的变化与反动作跳跃绝对力的变化呈正相关(p≤0.040,r≥0.414)。瘦体重增加与CRP浓度降低相关(p=0.004, ρ=-0.675)。结论脂肪量和体重的减少以及瘦体重的性别特异性变化得到证实。在军事训练期间,瘦质量也可能有利于保持身体表现和健康。
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引用次数: 0
Is Exercise-Induced Lactate Accumulation Associated with Changes in Acylated Ghrelin? A Systematic Review and Individual Participant Data Meta-analysis. 运动诱导的乳酸积累与乙酰化胃饥饿素的变化有关吗?系统评价与个体参与者数据荟萃分析。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003921
Seth F McCarthy,Jessica A L Tucker,Tom J Hazell
INTRODUCTIONLactate has been proposed to suppress the release and activation of the orexigenic peptide acylated ghrelin, though no study has synthesized available evidence from acute exercise trials.PURPOSETo determine if exercise-induced lactate accumulation predicts and/or is associated with changes in acylated ghrelin.METHODSA systematic search strategy was developed and conducted in four databases for studies exploring changes in acylated ghrelin and lactate during acute exercise interventions. Using Covidence, studies were identified and included if participants were between the ages of 18 and 65 y, healthy (absence of medical condition or disease), conducted an acute exercise trial, and measured both acylated ghrelin and lactate pre- and post-exercise. Corresponding authors of eligible studies were contacted for individual data and linear mixed-effect models were fitted and repeated measures correlations were conducted to determine if change in (Δ) lactate predicts and/or was associated with Δ acylated ghrelin and acylated ghrelin incremental area under the curve (iAUC).RESULTSTwelve data sets (169 participants) were included in the Δ acylated ghrelin analysis and nine data sets (105 participants) were included in the acylated ghrelin iAUC analysis. There was a significant effect of Δ lactate for both Δ acylated ghrelin (β=-8.1, SE=1.1, p<0.001) and Δ acylated ghrelin iAUC (β=-698, SE=69, p<0.001) and Δ lactate had a negative correlation with both outcomes (rm=-0.41, p<0.001; and rm=-0.59, p<0.001).CONCLUSIONSOverall, this study suggests that exercise-induced lactate accumulation significantly affects Δ acylated ghrelin and acylated ghrelin iAUC and is negatively associated, suggesting greater exercise-induced lactate accumulation would be associated with the suppression of ghrelin.
乳酸被认为可以抑制促氧肽酰化胃饥饿素的释放和激活,尽管没有研究从急性运动试验中合成可用的证据。目的确定运动诱导的乳酸积累是否预测和/或与酰化胃饥饿素的变化有关。方法在四个数据库中制定并实施了系统的搜索策略,以研究急性运动干预期间酰化胃饥饿素和乳酸的变化。如果参与者年龄在18至65岁之间,健康(没有医疗状况或疾病),进行了急性运动试验,并测量了运动前和运动后的酰化胃饥饿素和乳酸,则使用covid识别并纳入研究。联系符合条件的研究的通信作者获取个人数据,拟合线性混合效应模型,并进行重复测量相关性,以确定(Δ)乳酸的变化是否预测和/或与Δ酰化胃饥饿素和酰化胃饥饿素曲线下增量面积(iAUC)相关。结果12个数据集(169名受试者)被纳入Δ酰化胃饥饿素分析,9个数据集(105名受试者)被纳入酰化胃饥饿素iAUC分析。Δ乳酸对Δ酰化胃饥饿素(β=-8.1, SE=1.1, p<0.001)和Δ酰化胃饥饿素iAUC (β=-698, SE=69, p<0.001)均有显著影响,Δ乳酸与两者均呈负相关(rm=-0.41, p<0.001; rm=-0.59, p<0.001)。综上所述,本研究提示运动诱导乳酸积累显著影响Δ酰化胃饥饿素和酰化胃饥饿素iAUC,且呈负相关,提示运动诱导乳酸积累的增加可能与胃饥饿素的抑制有关。
{"title":"Is Exercise-Induced Lactate Accumulation Associated with Changes in Acylated Ghrelin? A Systematic Review and Individual Participant Data Meta-analysis.","authors":"Seth F McCarthy,Jessica A L Tucker,Tom J Hazell","doi":"10.1249/mss.0000000000003921","DOIUrl":"https://doi.org/10.1249/mss.0000000000003921","url":null,"abstract":"INTRODUCTIONLactate has been proposed to suppress the release and activation of the orexigenic peptide acylated ghrelin, though no study has synthesized available evidence from acute exercise trials.PURPOSETo determine if exercise-induced lactate accumulation predicts and/or is associated with changes in acylated ghrelin.METHODSA systematic search strategy was developed and conducted in four databases for studies exploring changes in acylated ghrelin and lactate during acute exercise interventions. Using Covidence, studies were identified and included if participants were between the ages of 18 and 65 y, healthy (absence of medical condition or disease), conducted an acute exercise trial, and measured both acylated ghrelin and lactate pre- and post-exercise. Corresponding authors of eligible studies were contacted for individual data and linear mixed-effect models were fitted and repeated measures correlations were conducted to determine if change in (Δ) lactate predicts and/or was associated with Δ acylated ghrelin and acylated ghrelin incremental area under the curve (iAUC).RESULTSTwelve data sets (169 participants) were included in the Δ acylated ghrelin analysis and nine data sets (105 participants) were included in the acylated ghrelin iAUC analysis. There was a significant effect of Δ lactate for both Δ acylated ghrelin (β=-8.1, SE=1.1, p<0.001) and Δ acylated ghrelin iAUC (β=-698, SE=69, p<0.001) and Δ lactate had a negative correlation with both outcomes (rm=-0.41, p<0.001; and rm=-0.59, p<0.001).CONCLUSIONSOverall, this study suggests that exercise-induced lactate accumulation significantly affects Δ acylated ghrelin and acylated ghrelin iAUC and is negatively associated, suggesting greater exercise-induced lactate accumulation would be associated with the suppression of ghrelin.","PeriodicalId":18500,"journal":{"name":"Medicine & Science in Sports & Exercise","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity Trajectories in the First Year Following ACL Reconstruction and Links to Early Markers of Osteoarthritis Development. 前交叉韧带重建后第一年的身体活动轨迹及其与骨关节炎发展早期标志物的联系。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003926
Christin Büttner,Louise Thoma,Caroline Lisee,Hyunwook Lee,Liubov Arbeeva,Natália Favoreto,Jeffrey Spang,Xiaojuan Li,Brian Pietrosimone
PURPOSEIdentify distinct MVPA trajectories between 2 and 12 months post-ACLR and compare tibiofemoral articular cartilage composition changes as well as patient reported outcomes (PROs) between trajectory groups.METHODSDevice-measured MVPA was collected at 2, 4, 6, and 12 months post-ACLR in individuals with ACLR. MVPA trajectories were identified using grouped-based trajectory modeling. Cartilage composition was measured preoperatively (preop) and at 12 months post-ACLR using change in T1ρ (ΔT1ρ) magnetic resonance imaging relaxation times in the lateral (LFC, LT) and medial (MFC, MT) femoral and tibial compartment. The Knee Injury and Osteoarthritis Outcomes Score (KOOS) was used to assess PROs at preop, 2, 4, 6, and 12 months post-ACLR. Differences in KOOS subscale scores and ΔT1ρ were compared between MVPA trajectory groups.RESULTSWe identified a consistent MVPA (74.5% of cohort) and high-increasing MVPA trajectory (25.5%). The high-increasing trajectory group engaged in more MVPA at all timepoints compared to the consistent group. The high-increasing trajectory group demonstrated greater ΔT1ρ in the LFC (i.e., deleterious changes in cartilage composition, p=0.006) and higher KOOS sport compared to the consistent MVPA group (p=0.037).CONCLUSIONSIndividuals between 2 and 12 months post-ACLR most commonly engage in the consistent MVPA trajectory. The high-increasing MVPA trajectory group demonstrated worsening LFC cartilage composition. These data indicate that high MVPA in the first 12 months post-ACLR may be linked to deleterious knee tissue changes but not worse PROs.
目的:确定aclr后2 - 12个月间不同的MVPA轨迹,比较轨迹组间胫股关节软骨组成的变化以及患者报告的预后(PROs)。方法在ACLR患者ACLR后2、4、6和12个月收集设备测量的MVPA。使用基于分组的轨迹建模方法识别MVPA轨迹。术前(preop)和aclr后12个月,利用外侧(LFC, LT)和内侧(MFC, MT)股骨和胫骨间室T1ρ (ΔT1ρ)磁共振成像松弛时间的变化测量软骨组成。膝关节损伤和骨关节炎预后评分(oos)用于评估aclr术后术前、2、4、6和12个月的PROs。比较MVPA轨迹组间kos亚量表得分和ΔT1ρ的差异。结果我们确定了一致的MVPA(74.5%的队列)和高增加的MVPA轨迹(25.5%)。高增长轨迹组在所有时间点的MVPA均高于稳定轨迹组。与一致MVPA组相比,高增加轨迹组在LFC中表现出更大的ΔT1ρ(即软骨组成的有害变化,p=0.006)和更高的oos运动(p=0.037)。结论aclr术后2 - 12个月的患者最常出现一致的MVPA轨迹。高升高的MVPA轨迹组显示LFC软骨组成恶化。这些数据表明,aclr术后前12个月的高MVPA可能与有害的膝关节组织改变有关,但与更严重的pro无关。
{"title":"Physical Activity Trajectories in the First Year Following ACL Reconstruction and Links to Early Markers of Osteoarthritis Development.","authors":"Christin Büttner,Louise Thoma,Caroline Lisee,Hyunwook Lee,Liubov Arbeeva,Natália Favoreto,Jeffrey Spang,Xiaojuan Li,Brian Pietrosimone","doi":"10.1249/mss.0000000000003926","DOIUrl":"https://doi.org/10.1249/mss.0000000000003926","url":null,"abstract":"PURPOSEIdentify distinct MVPA trajectories between 2 and 12 months post-ACLR and compare tibiofemoral articular cartilage composition changes as well as patient reported outcomes (PROs) between trajectory groups.METHODSDevice-measured MVPA was collected at 2, 4, 6, and 12 months post-ACLR in individuals with ACLR. MVPA trajectories were identified using grouped-based trajectory modeling. Cartilage composition was measured preoperatively (preop) and at 12 months post-ACLR using change in T1ρ (ΔT1ρ) magnetic resonance imaging relaxation times in the lateral (LFC, LT) and medial (MFC, MT) femoral and tibial compartment. The Knee Injury and Osteoarthritis Outcomes Score (KOOS) was used to assess PROs at preop, 2, 4, 6, and 12 months post-ACLR. Differences in KOOS subscale scores and ΔT1ρ were compared between MVPA trajectory groups.RESULTSWe identified a consistent MVPA (74.5% of cohort) and high-increasing MVPA trajectory (25.5%). The high-increasing trajectory group engaged in more MVPA at all timepoints compared to the consistent group. The high-increasing trajectory group demonstrated greater ΔT1ρ in the LFC (i.e., deleterious changes in cartilage composition, p=0.006) and higher KOOS sport compared to the consistent MVPA group (p=0.037).CONCLUSIONSIndividuals between 2 and 12 months post-ACLR most commonly engage in the consistent MVPA trajectory. The high-increasing MVPA trajectory group demonstrated worsening LFC cartilage composition. These data indicate that high MVPA in the first 12 months post-ACLR may be linked to deleterious knee tissue changes but not worse PROs.","PeriodicalId":18500,"journal":{"name":"Medicine & Science in Sports & Exercise","volume":"152 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145759900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rating Of Perceived Exertion as Prescription Tool to Maximize Oxygen Uptake Response During High-Intensity Interval Training. 在高强度间歇训练中,作为处方工具最大化氧摄取反应的感知运动等级。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003917
Daniel Bok,Emma Turk,Jere Gulin,Marija Rakovac,Carl Foster
PURPOSEThe aims of the study were to (a) investigate the prescriptive validity of Borg's category-ratio 10 (CR-10) rating of perceived exertion (RPE) scale for high-intensity interval training (HIIT) using the criterion of accumulated time ≥90% of maximal oxygen uptake (VO2max); (b) determine the optimal RPE category for HIIT prescription and (c) analyze the physiological responses to RPE-prescribed HIIT sessions.METHODSSeventeen (12 male) current and former physical education students (age: 24.2 ± 5 years, height: 181.3 ± 7.3, weight: 77.5 ± 12.2 kg; % body fat: 14.3 ± 4.3%) volunteered to participate in the study. Within four visits, separated by at least 48 hours, the participants performed a maximal incremental exercise test and three HIIT sessions. The HIIT sessions included three 3-minute intervals prescribed at RPE 6, 7 or 8 interspersed with 2-minute passive rest.RESULTSTime ≥90% VO2max and ≥90% maximal heart rate (HRmax) as well as mean and peak running speed (v), HR, VO2, respiratory frequency (ƒR), peak minute ventilation (VE), and blood lactate [La] were all significantly lower in HIITRPE6 compared to HIITRPE7 and HIITRPE8, while there were no significant differences between HIITRPE7 and HIITRPE8. Mean VE was significantly different between all three HIIT sessions indicating the validity of RPE for HIIT prescription.CONCLUSIONSRPE can be used to effectively prescribe long format HIIT sessions. RPE 7 appears to be an optimal prescription category as HIITRPE7 elicited similar cardiovascular and metabolic responses to HIITRPE8 but with lower ventilatory stress. VE appeared to be the main perceptual cue for the regulation of running speed, while VO2 was mainly governed by the dynamic of running speed adjustments during HIIT intervals.
目的本研究的目的是:(a)以累积时间≥最大摄氧量(VO2max)的90%为标准,探讨Borg的感知运动强度(RPE)量表的分类比10 (CR-10)评分对高强度间歇训练(HIIT)的规定效度;(b)确定HIIT处方的最佳RPE类别,(c)分析RPE规定的HIIT疗程的生理反应。方法17名(12名男性)在校生(年龄:24.2±5岁,身高:181.3±7.3,体重:77.5±12.2 kg,体脂率:14.3±4.3%)自愿参加研究。在四次访问中,间隔至少48小时,参与者进行了最大增量运动测试和三次HIIT会话。HIIT包括三次3分钟的间歇,RPE为6,7或8,中间穿插2分钟的被动休息。结果HIITRPE6组≥90% VO2max和≥90%最大心率(HRmax)、平均和峰值跑速(v)、HR、VO2、呼吸频率(ƒR)、峰值分钟通气(VE)、血乳酸[La]均显著低于HIITRPE7和HIITRPE8组,而HIITRPE7和HIITRPE8组间差异无统计学意义。平均VE在所有三个HIIT阶段之间有显著差异,表明RPE对HIIT处方的有效性。结论srpe可有效地规定长时间HIIT训练。RPE7似乎是一个最佳处方类别,因为HIITRPE7引起了与HIITRPE8相似的心血管和代谢反应,但通气应激较低。VE似乎是跑步速度调节的主要感知线索,而VO2主要受HIIT间歇期跑步速度调节的动态影响。
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引用次数: 0
A Natural Experiment of Childhood Lifestyle on Emotional Distress Outcomes Using a Birth Cohort of Typically Developing Children. 儿童生活方式对正常发育儿童情绪困扰结果的自然实验。
Pub Date : 2025-12-16 DOI: 10.1249/mss.0000000000003923
Arianne Imbeault,Julien Morizot,Linda S Pagani
PURPOSEMany youngsters have unhealthy lifestyle. This raises risks of emotional distress (i.e. depressive and anxiety symptoms). Conversely, those with emotional distress are also at risk of having an unhealthy lifestyle. We aim to examine the association between emotional distress and lifestyle in children.METHODSData were from the Quebec Longitudinal Study of Child Development which was collected in Quebec province, Canada. Lifestyle and emotional distress were assessed by questionnaires completed by mothers, teachers, and children at ages 8 (N = 1451, 52% girls), 10 (N = 1334), and 12 years (N = 1355). Latent profile analysis was used to derive lifestyle profiles. Logistic regression and mean difference analysis were conducted to test the associations between emotional distress and lifestyle profiles.RESULTSAt age 10 years, four profiles were found: (1) healthy (43 %); fair (38 %); inactive (15 %); and sedentary (4 %). Children in the sedentary lifestyle profile had significantly more depressive symptoms at age 12 years compared to the healthy lifestyle profiles (Mean Difference [MD] = -1.618, 95% CI = -2.841, -0.396, p = .009), the fair lifestyle profile (MD = -1.399, 95% CI = -2.629, -0.170, p = .03), and the inactive lifestyle profile (MD = -1.609, 95% CI = -2.966, -0.253, p = .02). Effect sizes were large (respectively d = 1.13, d = 0.97, and d = 1.12).CONCLUSIONSParents and schools should provide more opportunities for extracurricular physical activity from an early age. The study would have benefited from including distinct type of sport and electronic devices instead of aggregated variables to evaluate differential associations with emotional distress.
许多年轻人有不健康的生活方式。这增加了情绪困扰的风险(即抑郁和焦虑症状)。相反,那些有情绪困扰的人也有不健康生活方式的风险。我们的目的是研究儿童情绪困扰和生活方式之间的关系。方法数据来自加拿大魁北克省的魁北克儿童发展纵向研究。生活方式和情绪困扰通过母亲、教师和8岁(N = 1451, 52%女孩)、10岁(N = 1334)和12岁(N = 1355)儿童填写的问卷进行评估。使用潜在剖面分析得出生活方式剖面。采用Logistic回归和均值差异分析来检验情绪困扰与生活方式之间的关系。结果在10岁时,发现4种类型:(1)健康(43%);一般(38%);无活性(15%);久坐不动(4%)。与健康生活方式组相比,久坐生活方式组的儿童在12岁时明显有更多的抑郁症状(Mean Difference [MD] = -1.618, 95% CI = -2.841, -0.396, p = 0.009)、正常生活方式组(MD = -1.399, 95% CI = -2.629, -0.170, p = 0.03)和不活跃生活方式组(MD = -1.609, 95% CI = -2.966, -0.253, p = 0.02)。效应量较大(分别为d = 1.13、d = 0.97和d = 1.12)。结论家长和学校应尽早为孩子提供课外体育活动的机会。这项研究将受益于纳入不同类型的运动和电子设备,而不是汇总变量来评估与情绪困扰的不同关联。
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引用次数: 0
Longitudinal Bidirectional Associations Between Physical Activity and Cognitive Ability in Older Adults Across the UK, US, and China. 英国、美国和中国老年人身体活动与认知能力之间的纵向双向关联
Pub Date : 2025-12-15 DOI: 10.1249/mss.0000000000003911
Xinyue Zhang,Jiawei Zhao,BinBin Zhao,Li Xin
PURPOSEPhysical activity (PA) has been linked to better cognitive ability (CA), but the bidirectionality of this association and the role of activity intensity remain unclear. We aimed to examine bidirectional longitudinal associations between PA and CA across three national cohorts.METHODSWe used harmonized data from three population-based aging studies: the English Longitudinal Study of Ageing (ELSA), the US Health and Retirement Study (HRS), and the China Health and Retirement Longitudinal Study (CHARLS). Participants aged ≥50 years with three waves of data were included (n = 15,120). PA was categorized by intensity (light, moderate, vigorous) and self-reported at baseline and follow-up. CA was assessed via composite scores of memory, orientation, and numeracy. We applied linear mixed-effects models to estimate longitudinal bidirectional associations between PA (PA intensity) and CA, adjusting for sociodemographic and health-related covariates.RESULTSIn ELSA cohort, we observed modest but statistically significant bidirectional associations between PA and CA. In CHARLS cohort, the CA-PA association attenuated to non-significance after adjusting for chronic conditions, while the HRS cohort showed similar patterns to CHARLS. Notably, Moderate-intensity PA showed the most consistent longitudinal associations with subsequent cognitive outcomes across all cohorts (β = 0.024, p = 0.001). Evidence for reverse association was also observed across all cohorts (β = 0.016, p = 0.017). No systematic moderation by gender or baseline age was detected. Results were broadly comparable across cohorts, despite differences in measurement and cultural context.CONCLUSIONSRegular moderate-intensity PA may support cognitive health in later life, and cognitive function may in turn influence ongoing engagement in MPA. These findings underscore the value of reciprocal benefits of moderate-intensity PA as cognitive health strategies in aging populations.
体育活动(PA)与更好的认知能力(CA)有关,但这种关联的双向性和活动强度的作用尚不清楚。我们的目的是在三个国家队列中检查PA和CA之间的双向纵向关联。方法我们使用了三个基于人口的老龄化研究的统一数据:英国老龄化纵向研究(ELSA)、美国健康与退休研究(HRS)和中国健康与退休纵向研究(CHARLS)。纳入年龄≥50岁的三波数据参与者(n = 15,120)。PA按强度(轻度、中度、剧烈)和基线和随访时的自我报告进行分类。CA通过记忆、取向和计算能力的综合得分来评估。我们应用线性混合效应模型来估计PA (PA强度)和CA之间的纵向双向关联,并调整了社会人口统计学和健康相关协变量。结果在ELSA队列中,我们观察到PA和CA之间存在适度但有统计学意义的双向关联。在CHARLS队列中,经过慢性疾病调整后,CA-PA关联减弱至不显著,而HRS队列显示出与CHARLS相似的模式。值得注意的是,在所有队列中,中等强度PA与随后的认知结果表现出最一致的纵向关联(β = 0.024, p = 0.001)。在所有队列中也观察到反向关联的证据(β = 0.016, p = 0.017)。没有发现性别或基线年龄的系统性调节。尽管在测量和文化背景上存在差异,但结果在队列之间具有广泛的可比性。结论有规律的中等强度PA可能支持老年认知健康,认知功能可能反过来影响持续的MPA参与。这些发现强调了中等强度PA作为老年人认知健康策略的互惠效益的价值。
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引用次数: 0
Performance Prediction and Athlete categorization using the Anaerobic Power Reserve Framework in Rowing. 使用无氧动力储备框架的赛艇运动表现预测和运动员分类。
Pub Date : 2025-12-08 DOI: 10.1249/mss.0000000000003912
Ludwig Rappelt,Lars Donath,Tim Wiedenmann,Florian Micke,Sebastian Mühlenhoff,Steffen Held
PURPOSEWith the Olympic rowing distance reduced to 1500 m for 2028, the anaerobic power reserve (APR) framework has been proposed to evaluate anaerobic performance and differentiate physiological profiles. This study investigated performance predictions and athlete profiles using the APR framework and related physical performance measures.METHODSThirty-one female (simulated 2000-m performance (P2k) = 285.1 ± 36.0 W) and 63 male (P2k = 422.8 ± 62.2 W) (sub-)elite German rowers completed tests for maximal oxygen uptake (V̇O2max), maximal lactate accumulation rate (cLamax), peak power output (PPO), power at V̇O2max (MAP), at 2 mmol·L⁻¹ (P2) and 4 mmol·L⁻¹ blood lactate (P4), and P2k. Backward stepwise regression models were used to predict P2k and models performance was evaluated via a k-fold cross-validation approach. Commonality analyses and LGM metrics were used to assess predictor contribution, while k-means clustering based on the power reserve ratio (PRR = PPOꞏMAP -1) were used to identify athlete subgroups.RESULTSFor P2k prediction, P4, PPO, and V̇O2max in females (average results from k-fold cross-validation: R 2 = 0.90, RMSE = 9.3 W, MAE = 6.3 W), and P4, MAP, and PPO in males (R 2 = 0.93, RMSE = 16.2 W, MAE = 12.6 W) showed excellent model fits. Commonality analyses revealed ~90% shared variance contributions among predictors. K-means clustering identified sprint-type (females: PRR ≥1.52; males: PRR ≥1.66) and endurance-type rowers (females: PRR ≤1.43; males: PRR ≤1.62) along the PRR continuum.CONCLUSIONSKey predictors for P2k highlight the interplay between the aerobic and anaerobic systems. Moreover, the distinct sprint- and endurance-type clusters emphasize the physiological diversity among rowers, even among athletes with similar performance outcomes. Longitudinal PRR assessments may support talent identification and tailored training strategies.
随着2028年奥运会赛艇距离减少到1500米,提出了无氧动力储备(APR)框架来评估无氧性能和区分生理特征。本研究使用APR框架和相关的身体表现测量来调查成绩预测和运动员概况。方法31名女性(模拟2000米成绩(P2k) = 285.1±36.0 W)和63名男性(P2k = 422.8±62.2 W)(亚)优秀德国赛艇运动员完成了最大摄氧量(V O2max)、最大乳酸积累率(cLamax)、峰值输出功率(PPO)、V O2max功率(MAP)、2 mmol·L毒血症(P2)和4 mmol·L毒血症(P4)和P2k的测试。采用后向逐步回归模型预测P2k,并通过k-fold交叉验证方法评估模型的性能。共性分析和LGM指标用于评估预测因子的贡献,而基于能量储备比(PRR = PPOꞏMAP -1)的k均值聚类用于确定运动员亚群。结果对于P2k的预测,女性的P4、PPO和vo2max (k-fold交叉验证的平均结果:r2 = 0.90, RMSE = 9.3 W, MAE = 6.3 W)和男性的P4、MAP和PPO (r2 = 0.93, RMSE = 16.2 W, MAE = 12.6 W)具有很好的模型拟合性。共性分析显示,预测因子之间的共同方差贡献约为90%。K-means聚类识别出沿PRR连续体的冲刺型赛艇运动员(女性:PRR≥1.52,男性:PRR≥1.66)和耐力型赛艇运动员(女性:PRR≤1.43,男性:PRR≤1.62)。结论P2k的关键预测因素强调好氧和厌氧系统之间的相互作用。此外,不同的冲刺型和耐力型集群强调了赛艇运动员之间的生理多样性,即使在成绩相似的运动员之间也是如此。纵向PRR评估可以支持人才识别和量身定制的培训策略。
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引用次数: 0
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Medicine & Science in Sports & Exercise
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