S. Dwi, Setiawardani Febrianti, A. Zainul, S. Retno
{"title":"PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system","authors":"S. Dwi, Setiawardani Febrianti, A. Zainul, S. Retno","doi":"10.12991/mpj.2018.63","DOIUrl":"https://doi.org/10.12991/mpj.2018.63","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"14 1","pages":"259-266"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74542297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Due to its geographic location, variable climate and traditional culture, Turkey has a rich flora and the use of plants in folk medicine is very favorable. That practice and knowledge have been passed down from generation to generation. Ethnobotanical surveys are carried out to record traditional treatment methods of plants. In this study, which was prepared by screening of ethnobotanical researches made in Turkey, 241 taxa were recorded in the traditional treatment of hemorrhoids. Information about scientific and local names, families, used parts and usage patterns of these plants are given. According to the research results, the most commonly used plants in hemorrhoid treatment are plants belonging to Asteraceae, Lamiaceae, Rosaceae, Scrophulariaceae, Araceae, Polygonaceae and Cupressaceae families. The species commonly used in different regions of Turkey are Achillea sp., Arum sp., Cichorium intybus L., Dracunculus vulgaris Schott, Ecballium elaterium (L.) A. Rich., Ficus carica L., Hypericum perforatum L., H. scabrum L., Juglans regia L., Peganum harmala L., Rosa canina L., Rubus sp., Sambucus ebulus L., S. nigra L., Teucrium polium L., Urtica dioica L., Verbascum sp..
{"title":"Plants used in traditional treatment against hemorrhoids in Turkey","authors":"Meryem Seyda Erbay, A. Sarı","doi":"10.12991/MPJ.2018.49","DOIUrl":"https://doi.org/10.12991/MPJ.2018.49","url":null,"abstract":"Due to its geographic location, variable climate and traditional culture, Turkey has a rich flora and the use of plants in folk medicine is very favorable. That practice and knowledge have been passed down from generation to generation. Ethnobotanical surveys are carried out to record traditional treatment methods of plants. In this study, which was prepared by screening of ethnobotanical researches made in Turkey, 241 taxa were recorded in the traditional treatment of hemorrhoids. Information about scientific and local names, families, used parts and usage patterns of these plants are given. According to the research results, the most commonly used plants in hemorrhoid treatment are plants belonging to Asteraceae, Lamiaceae, Rosaceae, Scrophulariaceae, Araceae, Polygonaceae and Cupressaceae families. The species commonly used in different regions of Turkey are Achillea sp., Arum sp., Cichorium intybus L., Dracunculus vulgaris Schott, Ecballium elaterium (L.) A. Rich., Ficus carica L., Hypericum perforatum L., H. scabrum L., Juglans regia L., Peganum harmala L., Rosa canina L., Rubus sp., Sambucus ebulus L., S. nigra L., Teucrium polium L., Urtica dioica L., Verbascum sp..","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"1 1","pages":"110-132"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78369648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNAand RNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayed modest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1 Virginia/ATCC3/2009 (cytotoxicity >100 μM). Compounds 6 and 11 displayed activity against vesicular stomatitis virus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 μM) and 2 μM (cytotoxicity 20 μM), respectively). Neither of the compounds was active against HIV.
{"title":"Synthesis and antiviral activity evaluation of new 4-thiazolidinones bearing an imidazo[2,1-b]thiazole moiety","authors":"N. Güzeldemirci, E. Pehlivan, L. Naesens","doi":"10.12991/MPJ.2018.61","DOIUrl":"https://doi.org/10.12991/MPJ.2018.61","url":null,"abstract":"A series of new 4-thiazolidinone derivatives were synthesized and evaluated against diverse DNAand RNA-viruses in mammalian cell cultures. Some of the compounds were found to exhibit moderate antiviral activity. 3Propyl-2-[((6-(4-chlorophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-methyl-4-thiazolidinone 13, displayed modest yet consistent activity against three strains of influenza A virus, including the 2009 pandemic virus A/H1N1 Virginia/ATCC3/2009 (cytotoxicity >100 μM). Compounds 6 and 11 displayed activity against vesicular stomatitis virus in HeLa cells (antiviral EC50 values of 9 (cytotoxicity 100 μM) and 2 μM (cytotoxicity 20 μM), respectively). Neither of the compounds was active against HIV.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"6 1","pages":"237-248"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80777980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In vitro genotoxic and antigenotoxic effects of delphinidin chloride on human peripheral blood lymphocytes","authors":"Mehmet Tahir Husunet, H. B. Ila","doi":"10.12991/MPJ.2018.58","DOIUrl":"https://doi.org/10.12991/MPJ.2018.58","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"230 1","pages":"209-217"},"PeriodicalIF":0.0,"publicationDate":"2018-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84234503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Rangari, S. Killedar, S. Jadhav, Trupti Ghatage, F. Tamboli
http://doi.org/10.12991/mpj.2018.42 Marmara Pharm J 2018;22(1): 66-73 Received: 17.06.2017 / Accepted: 08.11.2017 Corresponding Author: Firoj A. Tamboli E-mail: firojtamboli143@gmail.com Phone: +91 9503709095 ORCID No: https://orcid.org/0000-0002-5809-6303 How to cite this article: Tamboli FA, Rangari VD, Killedar SG, Jadhav SU, Ghatage TS, Kore VP. Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.). Marmara Pharm J. 2018; 22 (1): 66-73. ABSTRACT: Bacopa monnieri Linn. an important medicinal plant of Scrophulariaceae family and is distributed in the wet and marshy lands throughout India, Nepal, Sri Lanka, China, Taiwan, and Hawaii. It is endangered species so it is necessary to preserve germplasm. The objective of this research work is the comparative phytochemical evaluation of natural and micro-propagated plants of Bacopa monnieri (BM). It shows the presence of various phytoconstituents namely, alkaloids, saponins, phenolics, and flavonoids. These phytoconstituents are responsible for anti-oxidant and various other activity of the plant. The protocols for tissue culture has been developed for regeneration of the BM plant from small part (nodal segment). The regenerated plant having the similar potential in terms of phytoconstituents. The protocols of Murashige and Skoog medium can be used for the clonal regeneration of plant on the large scale through which it can be protected and preserved for the long duration in small space. From the comparative phytochemical investigation by HPTLC, the phytoconstituents which occur in the micro propagated plant are similar to that of the natural plant of B. monnieri.
http://doi.org/10.12991/mpj.2018.42 Marmara Pharm, 2018;22(1): 66-73收稿日期:2017年6月17日/收稿日期:2017年11月8日通讯作者:Firoj A. Tamboli E-mail: firojtamboli143@gmail.com联系电话:+91 9503709095检索号码:https://orcid.org/0000-0002-5809-6303文章引用方式:Tamboli FA, Rangari VD, Killedar SG, Jadhav SU, Ghatage TS, korea VP。假马齿苋(Bacopa monnieri)天然植株与微繁植株的植物化学评价比较。Marmara Pharm J. 2018;22(1): 66-73。摘要:假马齿苋。一种重要的玄参科药用植物，分布于印度、尼泊尔、斯里兰卡、中国、台湾和夏威夷的潮湿和沼泽地带。它是濒危物种，有必要保存种质资源。本研究的目的是对假马齿苋(Bacopa monnieri, BM)的天然植物和微繁植物的植物化学评价进行比较。它显示了各种植物成分的存在，即生物碱、皂苷、酚类物质和类黄酮。这些植物成分负责植物的抗氧化和各种其他活性。已经制定了组织培养方案，以使BM植株从小部分(节段)再生。再生植物在植物成分方面具有相似潜力的再生植物Murashige和Skoog培养基方案可用于植物的大规模无性系再生，可在小空间内进行长期保护和保存。通过HPTLC对比植物化学研究发现，微繁植物中所含的植物成分与天然植物相似。
{"title":"Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.)","authors":"V. Rangari, S. Killedar, S. Jadhav, Trupti Ghatage, F. Tamboli","doi":"10.12991/MPJ.2018.42","DOIUrl":"https://doi.org/10.12991/MPJ.2018.42","url":null,"abstract":"http://doi.org/10.12991/mpj.2018.42 Marmara Pharm J 2018;22(1): 66-73 Received: 17.06.2017 / Accepted: 08.11.2017 Corresponding Author: Firoj A. Tamboli E-mail: firojtamboli143@gmail.com Phone: +91 9503709095 ORCID No: https://orcid.org/0000-0002-5809-6303 How to cite this article: Tamboli FA, Rangari VD, Killedar SG, Jadhav SU, Ghatage TS, Kore VP. Comparative phytochemical evaluation of natural and micropropagated plants of Bacopa monnieri (L.). Marmara Pharm J. 2018; 22 (1): 66-73. ABSTRACT: Bacopa monnieri Linn. an important medicinal plant of Scrophulariaceae family and is distributed in the wet and marshy lands throughout India, Nepal, Sri Lanka, China, Taiwan, and Hawaii. It is endangered species so it is necessary to preserve germplasm. The objective of this research work is the comparative phytochemical evaluation of natural and micro-propagated plants of Bacopa monnieri (BM). It shows the presence of various phytoconstituents namely, alkaloids, saponins, phenolics, and flavonoids. These phytoconstituents are responsible for anti-oxidant and various other activity of the plant. The protocols for tissue culture has been developed for regeneration of the BM plant from small part (nodal segment). The regenerated plant having the similar potential in terms of phytoconstituents. The protocols of Murashige and Skoog medium can be used for the clonal regeneration of plant on the large scale through which it can be protected and preserved for the long duration in small space. From the comparative phytochemical investigation by HPTLC, the phytoconstituents which occur in the micro propagated plant are similar to that of the natural plant of B. monnieri.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"17 1","pages":"66-73"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81713601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Charehsaz, Etil Guzelmeric, E. Acar, E. Yeşilada, S. Helvacıoğlu
{"title":"Comparatively Investigation of Grape Molasses Produced by Conventional and Industrial Techniques","authors":"M. Charehsaz, Etil Guzelmeric, E. Acar, E. Yeşilada, S. Helvacıoğlu","doi":"10.12991/MPJ.2018.39","DOIUrl":"https://doi.org/10.12991/MPJ.2018.39","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"116 1","pages":"44-51"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87792535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kayıran, T. Taşkın, Mahmoud Abudayyak, E. Ozkan
{"title":"In Vitro Antioxidant And Cytotoxic Activity of Muscari neglectum Growing in Turkey","authors":"S. Kayıran, T. Taşkın, Mahmoud Abudayyak, E. Ozkan","doi":"10.12991/mpj.2018.43","DOIUrl":"https://doi.org/10.12991/mpj.2018.43","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"20 2","pages":"74-79"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72586418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. I. H. Khan, M. Billah, M. S. Hossain, S. K. Ahamed
http://doi.org/10.12991/mpj.2018.47 Marmara Pharm J 2018;22(1): 96-102 Corresponding Author: Mohammad Salim Hossain E-mail: Email: pharmasalim@yahoo.com Phone: +8801711200410 ORCID No: 0000-0002-5710-1115 Received: 14.05.2017 / Accepted: 03.10.2017 ABSTRACT: Roots of Solanum violaceum (S. violaceum) is used traditionally in different therapeutic applications in Bangladesh. Root extract of S. violaceum was investigated for total phenolic content (TPC), antiobesity, anti-hyperlipidemic, membrane stability and thrombolytic activity. Total phenolic content (TPC) was determined using folin-ciocalteu method. High fat diet induced obese mice were used for anti obesity and antihyperlipidemic test. Body weight gain, blood total cholesterol, triglyceride level were analyzed. Thrombolytic and membrane stability activity were evaluated by using human erythrocytes. Total phenolic content in root extract of S. violaceum was calculated as 51.26 mg gallic acid equivalent GAE/g of dry weight. The extractive supplementation with dose of 200mg/ kg and 400mg/kg were capable of lowering the level of triglyceride and total cholesterol significantly (p<0.05) in high fat diet (HFD) induced obese mice in a dose dependent manner. As a membrane stabilizing agent, crude extract was able to inhibit the erythrocyte heamolysis significantly (p< 0.05) with a value of 28.02±5.09% and 32.97± 4.12% respectively for heat and hypotonic solution induced condition. Moreover, 21.56 ±2.62 % of clot lysis was exhibited by the extract for its thrombolytic activity. The root of S. violaceum justifies its potential as anti obese agent. Further research is recommended to find out the active metabolites from this source.
http://doi.org/10.12991/mpj.2018.47 Marmara Pharm J 2018;22(1): 96-102通讯作者:Mohammad Salim Hossain E-mail: Email: pharmasalim@yahoo.com电话:+8801711200410 ORCID No: 0000-0002-5710-1115收稿日期:14.05.2017 /接受日期:03.10.2017摘要:在孟加拉国，violaceum (S. violaceum)的根传统上用于不同的治疗应用。研究了堇菜根提取物的总酚含量(TPC)、抗肥胖、抗高脂血症、膜稳定性和溶栓活性。用folin-ciocalteu法测定总酚含量(TPC)。采用高脂饮食诱导肥胖小鼠进行抗肥胖和抗高脂血症试验。分析体重增加、血总胆固醇、甘油三酯水平。用人红细胞评价溶栓活性和膜稳定性。计算出堇菜根提取物中总酚含量为51.26 mg没食子酸当量GAE/g干重。添加200mg/ kg和400mg/kg提取物可显著降低高脂饮食诱导肥胖小鼠的甘油三酯和总胆固醇水平(p<0.05)，且呈剂量依赖性。作为一种膜稳定剂，粗提物对热、低渗条件下红细胞溶血的抑制作用显著(p< 0.05)，分别为28.02±5.09%和32.97±4.12%。其溶栓率为21.56±2.62%。紫罗兰的根证明了它作为抗肥胖剂的潜力。建议进一步研究从该来源中发现活性代谢物。
{"title":"Methanol extract of Solanum violaceum root possesess antiobesity, hypolipidemic, thrombolytic and membrane stabilizing activity","authors":"M. I. H. Khan, M. Billah, M. S. Hossain, S. K. Ahamed","doi":"10.12991/mpj.2018.47","DOIUrl":"https://doi.org/10.12991/mpj.2018.47","url":null,"abstract":"http://doi.org/10.12991/mpj.2018.47 Marmara Pharm J 2018;22(1): 96-102 Corresponding Author: Mohammad Salim Hossain E-mail: Email: pharmasalim@yahoo.com Phone: +8801711200410 ORCID No: 0000-0002-5710-1115 Received: 14.05.2017 / Accepted: 03.10.2017 ABSTRACT: Roots of Solanum violaceum (S. violaceum) is used traditionally in different therapeutic applications in Bangladesh. Root extract of S. violaceum was investigated for total phenolic content (TPC), antiobesity, anti-hyperlipidemic, membrane stability and thrombolytic activity. Total phenolic content (TPC) was determined using folin-ciocalteu method. High fat diet induced obese mice were used for anti obesity and antihyperlipidemic test. Body weight gain, blood total cholesterol, triglyceride level were analyzed. Thrombolytic and membrane stability activity were evaluated by using human erythrocytes. Total phenolic content in root extract of S. violaceum was calculated as 51.26 mg gallic acid equivalent GAE/g of dry weight. The extractive supplementation with dose of 200mg/ kg and 400mg/kg were capable of lowering the level of triglyceride and total cholesterol significantly (p<0.05) in high fat diet (HFD) induced obese mice in a dose dependent manner. As a membrane stabilizing agent, crude extract was able to inhibit the erythrocyte heamolysis significantly (p< 0.05) with a value of 28.02±5.09% and 32.97± 4.12% respectively for heat and hypotonic solution induced condition. Moreover, 21.56 ±2.62 % of clot lysis was exhibited by the extract for its thrombolytic activity. The root of S. violaceum justifies its potential as anti obese agent. Further research is recommended to find out the active metabolites from this source.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"10 1","pages":"96-102"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78490657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mastura Ibrahim, S. Azziz, Chee Fah Wong, Wan Mustaffa Wan Din, W. Mahamod, Yuhanis Mhd Bakri, M. S. Ahmad, Rozita Yahaya, N. Ismail, Wan Mohd Nuzul Hakimi Wan Salleh
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