{"title":"Factors Affecting Career Plans of Faculty of Pharmacy Students in Ege University and Their Evaluations about Career Symposium","authors":"Elif Gizem Karaca, B. Kiran","doi":"10.12991/MPJ.2018.38","DOIUrl":"https://doi.org/10.12991/MPJ.2018.38","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"54 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89480288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Qneibi, N. Jaradat, A. Zaid, N. Abu-Khalaf, Abdel-Razzak Natsheh, Fatima Hussen
{"title":"Evaluation of Taste, Total Phenols and Antioxidant for Fresh, Roasted, Shade dried and Boiled leaves of Edible Arum palaestinum Bioss","authors":"M. Qneibi, N. Jaradat, A. Zaid, N. Abu-Khalaf, Abdel-Razzak Natsheh, Fatima Hussen","doi":"10.12991/MPJ.2018.40","DOIUrl":"https://doi.org/10.12991/MPJ.2018.40","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"22 1","pages":"52-58"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74918616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Plants used as painkiller in traditional treatment in Turkey - II HEADACHE","authors":"S. Anıl, G. Melikoğlu, Meryem Seyda Erbay","doi":"10.12991/MPJ.2018.37","DOIUrl":"https://doi.org/10.12991/MPJ.2018.37","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"161 1","pages":"29-36"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76168533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Taşkın, M. Cam, Gizem Bulut, A. Hazar‐Yavuz, L. Kabasakal, L. Bitiş
{"title":"Antioxidant and anti-inflammatory activities of Phlomis pungens and Coridothymus capitatus","authors":"T. Taşkın, M. Cam, Gizem Bulut, A. Hazar‐Yavuz, L. Kabasakal, L. Bitiş","doi":"10.12991/MPJ.2018.44","DOIUrl":"https://doi.org/10.12991/MPJ.2018.44","url":null,"abstract":"","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"53 1","pages":"80-85"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79872722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Culex pipiens L. (Diptera: Culicidae) is an important vector of West Nile virus in many parts of the world. In this research, the essential oils obtained from Nepeta cadmea Boiss. (endemic for Turkey) and Pimpinella anisum L. were examined for larvicidal activity against second-third instar larvae of Cx. pipiens. The essential oils were distilled from aerial parts of N. cadmea and seeds of P. anisum by water distillation. The chemical composition of these oils was determined by gas chromatography-mass spectrometry (GC-MS). The lethal concentration 50 and 90 values of these essential oils were 28.7 and 49.51 ppm, and 39.82 and 74.57 ppm, respectively. As a result, both essential oils were found highly toxic to larvae of Cx. pipiens. Our results showed that the essential oils obtained from N. cadmea and P. anisum may be suitable for the development of potential new botanical insecticides.
{"title":"Chemical composition and larvicidal activity of essential oils from Nepeta cadmea Boiss. and Pimpinella anisum L. on the larvae of Culex pipiens L.","authors":"Emre Oz, Samed Koc, İ. Çi̇nbi̇lgel, A. Yanıkoğlu","doi":"10.12991/mpj.2018.70","DOIUrl":"https://doi.org/10.12991/mpj.2018.70","url":null,"abstract":"Culex pipiens L. (Diptera: Culicidae) is an important vector of West Nile virus in many parts of the world. In this research, the essential oils obtained from Nepeta cadmea Boiss. (endemic for Turkey) and Pimpinella anisum L. were examined for larvicidal activity against second-third instar larvae of Cx. pipiens. The essential oils were distilled from aerial parts of N. cadmea and seeds of P. anisum by water distillation. The chemical composition of these oils was determined by gas chromatography-mass spectrometry (GC-MS). The lethal concentration 50 and 90 values of these essential oils were 28.7 and 49.51 ppm, and 39.82 and 74.57 ppm, respectively. As a result, both essential oils were found highly toxic to larvae of Cx. pipiens. Our results showed that the essential oils obtained from N. cadmea and P. anisum may be suitable for the development of potential new botanical insecticides.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"20 1","pages":"322-327"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85333478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. Madan, Shronavi Patil, D. Mathure, Santosh P. Bahirat, R. Awasthi, K. Dua
The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID® 244 FP. The poorly soluble drug atorvastatin was adsorbed on and/or into SYLOID® 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID® 244 FP is done by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carr’s index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables volume of ethanol and amount of SYLOID® 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.
{"title":"Improving dissolution profile of poorly water-soluble drug using non-ordered mesoporous silica","authors":"J. Madan, Shronavi Patil, D. Mathure, Santosh P. Bahirat, R. Awasthi, K. Dua","doi":"10.12991/MPJ.2018.62","DOIUrl":"https://doi.org/10.12991/MPJ.2018.62","url":null,"abstract":"The aim of the study was to increase dissolution rate of atorvastatin by the use of mesoporous silica SYLOID® 244 FP. The poorly soluble drug atorvastatin was adsorbed on and/or into SYLOID® 244 FP in the ratios 1:1, 1:1.1.5, 1:2, 1:2.5, 1:3 and 1:3.5 via a wetness impregnation method. The absence of crystalline form and presence of hydrogen bond interaction between atorvastatin and SYLOID® 244 FP is done by Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The atorvastatin loaded matrix lacked in the crystalline form of atorvastatin and it showed improvement in the dissolution rate of ATC. The flowability of the atorvastatin loaded matrix powder was evaluated by bulk density, Carr’s index and angle of repose. This matrix was then processed into a tablet by direct compression method. A 32 full factorial design was applied to investigate the combined effect of two formulation variables volume of ethanol and amount of SYLOID® 244 FP. The tablets were evaluated for hardness, friability, drug content and drug dissolution studies. The solubility of atorvastatin-loaded matrix was increased up to 4.28 times. Atorvastatin tablet prepared from drug-loaded silica may provide a feasible approach for development of an oral formulation for this poorly water-soluble drug.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"37 1","pages":"249-258"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84059752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Azizi, A. Ghasemi, H. Asgarian-Omran, Zohreh Zal
Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.
{"title":"Cerium oxide nanoparticles sensitize non-small lung cancer cell to ionizing radiation","authors":"S. Azizi, A. Ghasemi, H. Asgarian-Omran, Zohreh Zal","doi":"10.12991/mpj.2018.68","DOIUrl":"https://doi.org/10.12991/mpj.2018.68","url":null,"abstract":"Radiotherapy is an important strategy for cancer treatment, but resistance of tumor cells to ionizing radiation (IR) still remains a main challenging issue related to radiotherapy. The aim of this study was to evaluate the sensitizing effect of cerium oxide nanoparticles (CNPs) on non-small lung cancer (A-549) cells exposure to IR. A-549 cells were treated with CNPs and exposed to IR at dose 2 Gy. The radiosensitizing effect of CNPs was evaluated by clonogenic assay and flowcytometry. The findings of this study showed that CNPs reduced the frequencies of A-549 colony when these cells were exposed to IR. CNPs treatment prior exposure to IR significantly increased the IR-induced apoptotic incidences in A-549 cells. The present study demonstrates that CNPs to be an effective sensitizer on apoptosis and cell death induced by IR in A-549 cells.","PeriodicalId":18529,"journal":{"name":"Marmara Pharmaceutical Journal","volume":"23 1","pages":"307-313"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83707768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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