The antiretroviral therapy (ART) enables an almost normal life with HIV infection. Does this also hold true for sexual intercourse, i.e. safe sex without condoms? The European PARTNER-study provides evidence for a very low risk of transmission for condomless sex under optimized conditions such as early, adherent and lasting ART (<200 RNA copies/ml) as well as stable partnerships. The risk of transmission is enhanced with non-compliance or shortlasting (< 6 months) ART, increased HIV-1 RNA load and frequent partnerships.
{"title":"Virus-free and cured? The “ART” of adherence. Current efficacy of anti-HIV therapy.","authors":"Thomas Herdegen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The antiretroviral therapy (ART) enables an almost normal life with HIV infection. Does this also hold true for sexual intercourse, i.e. safe sex without condoms? The European PARTNER-study provides evidence for a very low risk of transmission for condomless sex under optimized conditions such as early, adherent and lasting ART (<200 RNA copies/ml) as well as stable partnerships. The risk of transmission is enhanced with non-compliance or shortlasting (< 6 months) ART, increased HIV-1 RNA load and frequent partnerships.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 4","pages":"143-6"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Basic diagnostics includes inspection of the skin, palpation of leg and foot pulses and determination of the ankle-brachial-index. The hemodynamic relevance of the circulation problem is important for the therapeutic decision. For its determination several noninvasive procedures are available. Treadmill test can help to differentiate between vascular and other causes of walking limitation.
{"title":"Peripheral artery disease: diagnosis","authors":"Christine Espinola-Klein","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Basic diagnostics includes inspection of the skin, palpation of leg and foot pulses and determination of the ankle-brachial-index. The hemodynamic relevance of the circulation problem is important for the therapeutic decision. For its determination several noninvasive procedures are available. Treadmill test can help to differentiate between vascular and other causes of walking limitation.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 3","pages":"98-9"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36266482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebekka Lenssen, Ulrich Jaehde, Ronja Woltersdorf, Hanna M Seidling
For 12 years, the ‚Aktionsbündnis Patientensicherheit e.V. (APS)‘ has been developing tools for improving patient safety. Experts with different professional backgrounds are working alongside patients and self-help associations in different working groups to develop and publish problem-oriented best-practice recommendations. Since its foundation in 2005, APS has published more than 20 best-practice recommendations and is one of the most important institutions for patient safety in Germany. In this article, the aims and initiatives of one working group of the APS, i.e. the medication safety working group, are presented. The standardized concept for the development of best-practice recommendations is illustrated by the example of the recommendations for medication safety in hospitals.
{"title":"Working together to enhance medication safety: working group ‚medication safety‘ of the Aktionsbündnis Patientensicherheit e.V.","authors":"Rebekka Lenssen, Ulrich Jaehde, Ronja Woltersdorf, Hanna M Seidling","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>For 12 years, the ‚Aktionsbündnis Patientensicherheit e.V. (APS)‘ has been developing tools for improving patient safety. Experts with different professional backgrounds are working alongside patients and self-help associations in different working groups to develop and publish problem-oriented best-practice recommendations. Since its foundation in 2005, APS has published more than 20 best-practice recommendations and is one of the most important institutions for patient safety in Germany. In this article, the aims and initiatives of one working group of the APS, i.e. the medication safety working group, are presented. The standardized concept for the development of best-practice recommendations is illustrated by the example of the recommendations for medication safety in hospitals.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 3","pages":"120-3"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prevalence and incidence are measures to quantify the frequency of a certain disease. For correct interpretation of data the calculation of correct parameters, the right population under risk and the definition of cases have to be considered.
{"title":"Prevalence and incidence – what’s the difference?","authors":"Iris Hinneburg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prevalence and incidence are measures to quantify the frequency of a certain disease. For correct interpretation of data the calculation of correct parameters, the right population under risk and the definition of cases have to be considered.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 3","pages":"124-6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Endovascular therapy of peripheral artery disease is currently first-line-treatment for a lot of indications. This is based on positive outcomes of modern treatment strategies employing drug-eluting balloons and drug-eluting stents.
{"title":"Peripheral artery disease: endovascular therapy.","authors":"Michael Lichtenberg","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Endovascular therapy of peripheral artery disease is currently first-line-treatment for a lot of indications. This is based on positive outcomes of modern treatment strategies employing drug-eluting balloons and drug-eluting stents.</p>","PeriodicalId":18540,"journal":{"name":"Medizinische Monatsschrift fur Pharmazeuten","volume":"40 3","pages":"102-6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36265454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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