Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.11.242
M. Ahmad, Sathees B. C. Chandra
In cases of unsuccessful endodontic treatment, E. faecalis is commonly detected and remains popular among the scientific community for in vitro and in vivo research. The nature of the bacteria's predominance is dependent on the difficulty in cleaning the apical portion of the tooth and E. faecalis' capacity to grow deep into the dentinal tubules. The purpose of this review is to gather current research on root canal disinfection against E. faecalis. In this literature review, four databases were searched: PubMed, EBSCOhost, ScienceDirect, and Google Scholar, with explicit inclusion and exclusion criteria. The compiled review shows that a predominant multi-microbial community within a persistent root canal infection include Porphyromonas gingivalis, Fusobacterium nucleatum, and Enterococcus faecalis. E. faecalis produces moderate biofilms and causes infection through its virulence factors such as esp, cylA, ace, gelE, asa, and efaA. Several disinfecting agents and approaches have been explored for their capacity to eradicate E. faecalis and penetrate the dentinal tubules. Sodium hypochlorite (NaOCl) and chlorhexidine (CHX) gel eliminate E. faecalis and other resistant microbes such as Staphylococcus aureus, and Escherichia coli. Combing NaOCl irrigation with the following: Photon-induced photoacoustic streaming, passive ultrasonic irrigation, and diode laser irradiation, eradicates E. faecalis. The current research has shifted towards nanoparticles against E. faecalis because of its dissolution capacity, size, and antimicrobial efficacy. E. faecalis resists calcium hydroxide through its proton pump mechanism, but it is susceptible to Ca(OH)2 when applying a proton pump inhibitor or chlorhexidine.
{"title":"The microbial community of persistent endodontic infection and the use of root canal disinfectants against E. faecalis: In vitro and in vivo review","authors":"M. Ahmad, Sathees B. C. Chandra","doi":"10.5455/medscience.2022.11.242","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.242","url":null,"abstract":"In cases of unsuccessful endodontic treatment, E. faecalis is commonly detected and remains popular among the scientific community for in vitro and in vivo research. The nature of the bacteria's predominance is dependent on the difficulty in cleaning the apical portion of the tooth and E. faecalis' capacity to grow deep into the dentinal tubules. The purpose of this review is to gather current research on root canal disinfection against E. faecalis. In this literature review, four databases were searched: PubMed, EBSCOhost, ScienceDirect, and Google Scholar, with explicit inclusion and exclusion criteria. The compiled review shows that a predominant multi-microbial community within a persistent root canal infection include Porphyromonas gingivalis, Fusobacterium nucleatum, and Enterococcus faecalis. E. faecalis produces moderate biofilms and causes infection through its virulence factors such as esp, cylA, ace, gelE, asa, and efaA. Several disinfecting agents and approaches have been explored for their capacity to eradicate E. faecalis and penetrate the dentinal tubules. Sodium hypochlorite (NaOCl) and chlorhexidine (CHX) gel eliminate E. faecalis and other resistant microbes such as Staphylococcus aureus, and Escherichia coli. Combing NaOCl irrigation with the following: Photon-induced photoacoustic streaming, passive ultrasonic irrigation, and diode laser irradiation, eradicates E. faecalis. The current research has shifted towards nanoparticles against E. faecalis because of its dissolution capacity, size, and antimicrobial efficacy. E. faecalis resists calcium hydroxide through its proton pump mechanism, but it is susceptible to Ca(OH)2 when applying a proton pump inhibitor or chlorhexidine.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89922300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.11.231
E. Kahraman, M. Senturk, H. Aladag, Engin m
Gestational diabetes mellitus (GDM) is a systemic disease that has poor maternal and fetal health outcomes. Patients who are diagnosed with GDM are more likely to encounter cardiovascular system diseases during pregnancy and after birth. Carotid intima-media thickness (CIMT) is used as an early indicator of diseases such as coronary artery disease. This study aims to define the effects of hyperglycemia at an early term using CIMT, maternal and fetal doppler flows in patients diagnosed with GDM. The study included 132 pregnant women who had reached the 24th gestational week. (GDM group n=65, Control group n=67) Comparisons were performed between women with similar demographic characteristics who received a 100-gr oral glucose test (OGT) and GDM diagnosis and who did not. The participants’ routine hemograms and biochemical tests were done during OGT. Fetal biometrics, amniotic fluid index, uterine artery doppler flow, and bilateral CIMT measurements were performed during the obstetric examinations. Gravida, para, and live birth rates of the GDM group participants were higher than those of the control group (p=0.003, 0.002, 0.002 respectively). The amniotic fluid index was found to be higher in the GDM group (p<0.001). Fasting glucose values and platelet counts were higher in the GDM group (p=0.031 and p<0.001). Other laboratory data demonstrated no statistically meaningful differences between the groups (p>0.05). When the doppler measurements were compared, umbilical artery pulsatility index values were discovered to be similar between the groups (p=0.509). While the right uterine artery (UtA) pulsatility index was higher in the GDM group (p<0.001), no statistically significant differences were found between the groups in terms of the left UtA pulsatility index (p=0.485). Right and left CIMTs were higher in the GDM group (p=0.001, p<0.001, p<0.001 respectively). While in the GDM group there was a positive correlation between the thrombocyte level and uterine artery resistance (r=0.336, p=0.006; r=0.397, p=0.044 respectively), no similar correlations were found in the control group. This study found that GDM patients had inflammation, increased resistance in uterine artery flow, and increased CIMT. It has been shown, there is a correlation between CIMT and glucose levels and between thrombocytosis and UtA resistance in GDM patients. Uterine artery doppler data and CIMT measurements could be used as an indicator of systemic inflammation and cardiovascular disease in patients with GDM.
{"title":"Vascular effects of gestational diabetes can be recognized by carotid intima-media thickness: a prospective case-control study","authors":"E. Kahraman, M. Senturk, H. Aladag, Engin m","doi":"10.5455/medscience.2022.11.231","DOIUrl":"https://doi.org/10.5455/medscience.2022.11.231","url":null,"abstract":"Gestational diabetes mellitus (GDM) is a systemic disease that has poor maternal and fetal health outcomes. Patients who are diagnosed with GDM are more likely to encounter cardiovascular system diseases during pregnancy and after birth. Carotid intima-media thickness (CIMT) is used as an early indicator of diseases such as coronary artery disease. This study aims to define the effects of hyperglycemia at an early term using CIMT, maternal and fetal doppler flows in patients diagnosed with GDM. The study included 132 pregnant women who had reached the 24th gestational week. (GDM group n=65, Control group n=67) Comparisons were performed between women with similar demographic characteristics who received a 100-gr oral glucose test (OGT) and GDM diagnosis and who did not. The participants’ routine hemograms and biochemical tests were done during OGT. Fetal biometrics, amniotic fluid index, uterine artery doppler flow, and bilateral CIMT measurements were performed during the obstetric examinations. Gravida, para, and live birth rates of the GDM group participants were higher than those of the control group (p=0.003, 0.002, 0.002 respectively). The amniotic fluid index was found to be higher in the GDM group (p<0.001). Fasting glucose values and platelet counts were higher in the GDM group (p=0.031 and p<0.001). Other laboratory data demonstrated no statistically meaningful differences between the groups (p>0.05). When the doppler measurements were compared, umbilical artery pulsatility index values were discovered to be similar between the groups (p=0.509). While the right uterine artery (UtA) pulsatility index was higher in the GDM group (p<0.001), no statistically significant differences were found between the groups in terms of the left UtA pulsatility index (p=0.485). Right and left CIMTs were higher in the GDM group (p=0.001, p<0.001, p<0.001 respectively). While in the GDM group there was a positive correlation between the thrombocyte level and uterine artery resistance (r=0.336, p=0.006; r=0.397, p=0.044 respectively), no similar correlations were found in the control group. This study found that GDM patients had inflammation, increased resistance in uterine artery flow, and increased CIMT. It has been shown, there is a correlation between CIMT and glucose levels and between thrombocytosis and UtA resistance in GDM patients. Uterine artery doppler data and CIMT measurements could be used as an indicator of systemic inflammation and cardiovascular disease in patients with GDM.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83316090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.02.030
O. Ozhan, Z. Ulutas, Seray Serduman, Leyla Buyukkorkmaz, A. Yıldız, Ahmet Ulu, N. Vardı, B. Ateş, H. Parlakpınar
Atypical antidepressant mirtazapine (MIR) is primarily used to treat major depressive disorder. It has not been clarified whether cardiovascular uncertainties and mechanisms of action emerge as problems during the use of mirtazapine. Cisplatin (CIS) is an effective anti-cancer medication used to treat a variety of human malignancies. There were four groups of 32 Wistar albino male rats in all. Rats were split into 4 groups at random. 1. Control Group, 2. CIS Group, 3. MIR Group, 4. MIR+CIS Group. On the 15th day of the study, ECG, heart rate, and blood pressure were determined. Histopathological and biochemical analyses were carried out on cardiac and vascular tissue samples. Comparing the CIS group to the other groups, blood pressure was considerably lower in the CIS group (p<0.05). In vascular tissue examination, catalase and superoxide dismutase levels were substantially higher in the control, MIR, and MIR+CIS groups, similar to those of the myocardium, compared to the CIS group (p<0.05). While the CIS group had the highest malondialdehyde level, it was much lower in all other groups in both myocardial and vascular tissue (p<0.05). It was observed that the congestion persisted, but the interstitial edema's intensity was much less severe in the MIR+CIS group than in the CIS group (p=0.009). We sought to clarify the function of the oxidative system, tissue-level histological alterations, the possibility that mirtazapine protects against CIS cardiotoxicity, and the role of MIR in cardio-oncology in this study. In this study, we demonstrated the possible protective effect of MIR in CIS-mediated cardiotoxicity and its antioxidant effect mechanism.
{"title":"Effects of mirtazapine on cisplatin cardiotoxicity in rats","authors":"O. Ozhan, Z. Ulutas, Seray Serduman, Leyla Buyukkorkmaz, A. Yıldız, Ahmet Ulu, N. Vardı, B. Ateş, H. Parlakpınar","doi":"10.5455/medscience.2023.02.030","DOIUrl":"https://doi.org/10.5455/medscience.2023.02.030","url":null,"abstract":"Atypical antidepressant mirtazapine (MIR) is primarily used to treat major depressive disorder. It has not been clarified whether cardiovascular uncertainties and mechanisms of action emerge as problems during the use of mirtazapine. Cisplatin (CIS) is an effective anti-cancer medication used to treat a variety of human malignancies. There were four groups of 32 Wistar albino male rats in all. Rats were split into 4 groups at random. 1. Control Group, 2. CIS Group, 3. MIR Group, 4. MIR+CIS Group. On the 15th day of the study, ECG, heart rate, and blood pressure were determined. Histopathological and biochemical analyses were carried out on cardiac and vascular tissue samples. Comparing the CIS group to the other groups, blood pressure was considerably lower in the CIS group (p<0.05). In vascular tissue examination, catalase and superoxide dismutase levels were substantially higher in the control, MIR, and MIR+CIS groups, similar to those of the myocardium, compared to the CIS group (p<0.05). While the CIS group had the highest malondialdehyde level, it was much lower in all other groups in both myocardial and vascular tissue (p<0.05). It was observed that the congestion persisted, but the interstitial edema's intensity was much less severe in the MIR+CIS group than in the CIS group (p=0.009). We sought to clarify the function of the oxidative system, tissue-level histological alterations, the possibility that mirtazapine protects against CIS cardiotoxicity, and the role of MIR in cardio-oncology in this study. In this study, we demonstrated the possible protective effect of MIR in CIS-mediated cardiotoxicity and its antioxidant effect mechanism.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76969944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.12.277
M. Saygılı, A. Tekin, Mustafa B Ayaz, M. Bayraktar
Primary aim of this study to evaluate the functional results and complications of the patients aged 70 and over whom are treated with proximal femoral nail (PFN) because of hip fracture. 128 patients out of 223 patients were included in the study, who were aged 70 and over, to whom treated with proximal femoral nail because of hip fracture in our clinic between 2006 and 2014. Since 26 of these 128 patients who were included in this study passed away before the follow up period of 1 year, they were excluded from the study. Fractures were evaluated by AO/OTA classification. Their Singh index and morphological cortical indexes were calculated from the pre-surgery radiographies. The functional situations of the patients were evaluated by Harris hip score. Average age of the evaluated 102 patients was 81.13 (70-98), 44 of them were male, 58 of them were female. According to AO/OTA fracture classification 48 of them were 31-A1, 25 of them were 31-A2, 29 of them were 31-A3. 54 fractures were on the left hip, 48 fractures were on the right hip. Average Singh index was 2.72 (1-5), average morphological cortical index was 2.94 (2.1-3.7), average Harris hip score was 74.3 (49-88). 4 patients have had complications after surgery and revised with other treatment modalities. Since the functional results are on a satisfactory level, in our opinion as well, proximal femoral nail should be considered among the surgical treatments in the elderly patients with hip fracture.
{"title":"Is the proximal femoral nail a favourable option for trochanteric femur fractures in osteopenic elderly patients?","authors":"M. Saygılı, A. Tekin, Mustafa B Ayaz, M. Bayraktar","doi":"10.5455/medscience.2022.12.277","DOIUrl":"https://doi.org/10.5455/medscience.2022.12.277","url":null,"abstract":"Primary aim of this study to evaluate the functional results and complications of the patients aged 70 and over whom are treated with proximal femoral nail (PFN) because of hip fracture. 128 patients out of 223 patients were included in the study, who were aged 70 and over, to whom treated with proximal femoral nail because of hip fracture in our clinic between 2006 and 2014. Since 26 of these 128 patients who were included in this study passed away before the follow up period of 1 year, they were excluded from the study. Fractures were evaluated by AO/OTA classification. Their Singh index and morphological cortical indexes were calculated from the pre-surgery radiographies. The functional situations of the patients were evaluated by Harris hip score. Average age of the evaluated 102 patients was 81.13 (70-98), 44 of them were male, 58 of them were female. According to AO/OTA fracture classification 48 of them were 31-A1, 25 of them were 31-A2, 29 of them were 31-A3. 54 fractures were on the left hip, 48 fractures were on the right hip. Average Singh index was 2.72 (1-5), average morphological cortical index was 2.94 (2.1-3.7), average Harris hip score was 74.3 (49-88). 4 patients have had complications after surgery and revised with other treatment modalities. Since the functional results are on a satisfactory level, in our opinion as well, proximal femoral nail should be considered among the surgical treatments in the elderly patients with hip fracture.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"287 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77014925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.05.078
Adem Bora, K. Durmuş, Selim Cam, E. Altuntaş
In the evaluation after septorhinoplasty (SRP), the surgeon's plan and the patient's expectations may not always be realised. Therefore, in our prospective case-control study, we aimed to investigate whether the Sinonasal Outcome Test (SNOT-22) and Nasal Obstruction Symptom Evaluation Scales (NOSE), which have been validated in different patient populations in Turkish, are appropriate for evaluating SRP cases and their relationship with each other. Preoperative and postoperative data of NOSE and SNOT-22 questionnaires of 125 cases diagnosed with traumatic septum deviation and external nasal deformity and decided to be operated were analyzed. It was calculated that the SNOT-22 score of those with high/low preoperative NOSE scores was also high/low with a 53.6% probability and that the SNOT-22 score of those with high/low postoperative NOSE scores was also high/low with a 69.9% probability, indicating a positive and high-level relationship between postoperative NOSE and SNOT-22 measurements. When the answers given to all questions in SNOT-22 were evaluated separately, it was observed that the most disturbing symptoms of the cases were nasal obstruction at 78.4% and the need to blow the nose at 46.4% in the preoperative period, and nasal obstruction with 64.8% and the need to blow nose with 37.6% in the postoperative period. The most dramatic changes in the answers to SNOT-22 questions were observed in the patient's feelings of frustrated/restless/irritable, sadness, and embrassed. SNOT-22 and NOSE questionnaires can be used interchangeably to evaluate the functional status of patients undergoing SRP surgery.
{"title":"Are the sinonasal outcome test and nasal obstruction symptom evaluation scale questionnaires suitable for assessing the quality of life after septorhinoplasty? A prospective case-control study","authors":"Adem Bora, K. Durmuş, Selim Cam, E. Altuntaş","doi":"10.5455/medscience.2023.05.078","DOIUrl":"https://doi.org/10.5455/medscience.2023.05.078","url":null,"abstract":"In the evaluation after septorhinoplasty (SRP), the surgeon's plan and the patient's expectations may not always be realised. Therefore, in our prospective case-control study, we aimed to investigate whether the Sinonasal Outcome Test (SNOT-22) and Nasal Obstruction Symptom Evaluation Scales (NOSE), which have been validated in different patient populations in Turkish, are appropriate for evaluating SRP cases and their relationship with each other. Preoperative and postoperative data of NOSE and SNOT-22 questionnaires of 125 cases diagnosed with traumatic septum deviation and external nasal deformity and decided to be operated were analyzed. It was calculated that the SNOT-22 score of those with high/low preoperative NOSE scores was also high/low with a 53.6% probability and that the SNOT-22 score of those with high/low postoperative NOSE scores was also high/low with a 69.9% probability, indicating a positive and high-level relationship between postoperative NOSE and SNOT-22 measurements. When the answers given to all questions in SNOT-22 were evaluated separately, it was observed that the most disturbing symptoms of the cases were nasal obstruction at 78.4% and the need to blow the nose at 46.4% in the preoperative period, and nasal obstruction with 64.8% and the need to blow nose with 37.6% in the postoperative period. The most dramatic changes in the answers to SNOT-22 questions were observed in the patient's feelings of frustrated/restless/irritable, sadness, and embrassed. SNOT-22 and NOSE questionnaires can be used interchangeably to evaluate the functional status of patients undergoing SRP surgery.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73753859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2022.10.218
N. Son
{"title":"Association of nutrition literacy level with sociodemographic data: Case of Afyonkarahisar","authors":"N. Son","doi":"10.5455/medscience.2022.10.218","DOIUrl":"https://doi.org/10.5455/medscience.2022.10.218","url":null,"abstract":"<jats:p />","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73989674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.06.081
Sevgi Taşolar, A. Sığırcı
Nasal obstruction is potentially severe when it affects neonates because nasal breathing is predominant during this period. An accurate assessment of nasal airway obstruction should be based on a comparison of the patient's nasal cavity dimensions with precise "normal values". For this reason, we aimed in this study to evaluate the nasal morphometry in newborns and infants with Computed Tomography (CT) in our region. CT images of 134 children who had no facial and cranial anomalies and no pathology were evaluated. In the axial section, the total choana width, right lateral width of the choana, left lateral width of the nasal cavity, the posterior width of the vomer, total aperture width (AW), right aperture width (RAW) and left aperture width were measured in all participants. The study group was divided into 4 age categories: 0-30 days, 31-90 days, 91-180 days and 181-360 days. When the choanal measurements of the groups were evaluated, there was a significant difference between the groups in the choanal measurements (p<0.05, for all), but no difference was observed between the groups in terms of vomer measurements. While there was a significant difference between the groups in terms of AW measurement, there was a significant difference only between Group 1 and Group 4 in terms of RAW value. There was also a positive correlation between age and choanal and aperture values (p<0.05 for all), while no correlation was observed with vomer measurements The normal widths of the choanal and anterior nasal aperture in infants in our region were defined according to months and gender in our study. Considering that there may be social differences, knowing the normative values in normal healthy individuals is of great importance in the evaluation of clinical and pathological conditions.
{"title":"Measurement of nasal anterior aperture and choana by computed tomography in newborns and infants","authors":"Sevgi Taşolar, A. Sığırcı","doi":"10.5455/medscience.2023.06.081","DOIUrl":"https://doi.org/10.5455/medscience.2023.06.081","url":null,"abstract":"Nasal obstruction is potentially severe when it affects neonates because nasal breathing is predominant during this period. An accurate assessment of nasal airway obstruction should be based on a comparison of the patient's nasal cavity dimensions with precise \"normal values\". For this reason, we aimed in this study to evaluate the nasal morphometry in newborns and infants with Computed Tomography (CT) in our region. CT images of 134 children who had no facial and cranial anomalies and no pathology were evaluated. In the axial section, the total choana width, right lateral width of the choana, left lateral width of the nasal cavity, the posterior width of the vomer, total aperture width (AW), right aperture width (RAW) and left aperture width were measured in all participants. The study group was divided into 4 age categories: 0-30 days, 31-90 days, 91-180 days and 181-360 days. When the choanal measurements of the groups were evaluated, there was a significant difference between the groups in the choanal measurements (p<0.05, for all), but no difference was observed between the groups in terms of vomer measurements. While there was a significant difference between the groups in terms of AW measurement, there was a significant difference only between Group 1 and Group 4 in terms of RAW value. There was also a positive correlation between age and choanal and aperture values (p<0.05 for all), while no correlation was observed with vomer measurements The normal widths of the choanal and anterior nasal aperture in infants in our region were defined according to months and gender in our study. Considering that there may be social differences, knowing the normative values in normal healthy individuals is of great importance in the evaluation of clinical and pathological conditions.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74065204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.138
Bulent Halaclar
Obesity is a global health problem, however, there is no consensus on the treatment for patients with a BMI between 30 and 35. Intragastric botulinum toxin injection (IGBT) has been proposed as a new endoscopic treatment for obesity, with the potential to delay gastric emptying and increase satiety by temporarily paralyzing the injected area. A retrospective study was conducted on 157 patients who received antral or fundus dominant IGBT and were followed up for 6 months with a diet program from January 2020 to December 2022. The patients were divided into three groups: Group 1 consisted of patients who received more injections in the fundus during IGBT, group 2 consisted of patients who received more injections in the antrum during IGBT, and group 3 consisted of patients who were only followed up with a diet program. Group 1 patients received 10 fundus and 10 antrum injections, while group 2 patients received 18 antrum and 2 fundus injections. Group 3 patients were only followed up with a diet program. Both antral and fundus dominant IGBT were effective in reducing body weight, and there was a significant difference between the two groups in terms of weight loss. Both groups 1 and 2 had significantly greater weight loss than group 3 (p<0.001). Antral and fundus dominant IGBT can be considered as a potential treatment option for obese patients with a BMI between 30 and 35 who do not meet the criteria for bariatric surgery.
{"title":"Comparison of botulinum toxin applications in the treatment of obesity","authors":"Bulent Halaclar","doi":"10.5455/medscience.2023.08.138","DOIUrl":"https://doi.org/10.5455/medscience.2023.08.138","url":null,"abstract":"Obesity is a global health problem, however, there is no consensus on the treatment for patients with a BMI between 30 and 35. Intragastric botulinum toxin injection (IGBT) has been proposed as a new endoscopic treatment for obesity, with the potential to delay gastric emptying and increase satiety by temporarily paralyzing the injected area. A retrospective study was conducted on 157 patients who received antral or fundus dominant IGBT and were followed up for 6 months with a diet program from January 2020 to December 2022. The patients were divided into three groups: Group 1 consisted of patients who received more injections in the fundus during IGBT, group 2 consisted of patients who received more injections in the antrum during IGBT, and group 3 consisted of patients who were only followed up with a diet program. Group 1 patients received 10 fundus and 10 antrum injections, while group 2 patients received 18 antrum and 2 fundus injections. Group 3 patients were only followed up with a diet program. Both antral and fundus dominant IGBT were effective in reducing body weight, and there was a significant difference between the two groups in terms of weight loss. Both groups 1 and 2 had significantly greater weight loss than group 3 (p<0.001). Antral and fundus dominant IGBT can be considered as a potential treatment option for obese patients with a BMI between 30 and 35 who do not meet the criteria for bariatric surgery.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135651862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-01DOI: 10.5455/medscience.2023.08.133
Sevgi Kutlusoy, Erdi Koca, Mesut Oterkus
Many methods have been attempted for the treatment of severe acute respiratory failure caused by COVID-19. One of these methods is immune plasma therapy. In this study, we aimed to evaluate the efficacy of immune plasma therapy using laboratory parameters and the effect of the time of initiation of immune plasma therapy on mortality in patients with COVID-19 who developed severe acute respiratory failure. 74 patients who were diagnosed with COVID-19 during hospitalization and given immune plasma in the intensive care unit were included in our study. Demographic data, comorbid diseases, time of immune plasma administration (first 4 days and after the 4th day), and laboratory and mortality data before and 1 and 2 days after plasma administration were recorded retrospectively. Analysis of the data we obtained in our study showed no difference in mortality between immune plasma administration within the first 4 days and after 4 days. In the group that received immune plasma transfusions in the first 4 days, glucose was lower, while creatinine and AST values were higher. The urea, leukocyte, neutrophil, PO2, PCO2, PCT, and D-dimer values of the patients 1 day and 2 days after immune plasma transfusion was higher than the pre-transfusion values, while CK, albumin and CRP values were lower. Immune plasma transfusion therapy improved laboratory parameters supporting clinical improvement due to decreased viral load in patients with COVID-19 who developed severe acute respiratory failure; however, it did not affect mortality and the number of patients discharged was higher in the group given early treatment (first 4 days). We suggest that early immune plasma administration may be an adjunctive treatment option to improve clinical recovery and reduce mortality until a definitive and permanent cure is found under pandemic conditions.
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In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy/radiochemotherapy between 2010 and 2017. The effect of proposed prognostic factors on overall survival (OS) and disease-free survival (DFS) was evaluated with univariate and multivariate analyses. Median age was 56.63 (range, 24-84) years and the median Karnofsky Performance Status (KPS) at diagnosis was 89% (range, 50-100%). Most the cases (n=69; 87.1%)were histologically diagnosed as World Health Organization (WHO) grade IV. At a median follow-up of 12 months, OS and DFS were 12 and 8 months, respectively. Although age, KPS, IDH1, p53 and Ki-67 status were found to be statistically significant among the prognostic factors affecting OS in univariate analyses, only KPS, p53 and Ki-67 were statistically significant in multivariate analysis.In contrast, age, KPS, IDH1, and Ki-67 were found to be significant factors for DFS in univariate analysis, while only KPS and Ki-67 were found to be significant factors for DFS in multivariate analysis. KPS was the most important prognostic factor for OS and DFS. In the evaluation of postoperative histopathological findings, p53 and Ki-67 were found to be prognostic for OS while only Ki-67 was prognostic for DFS. However, IDH1, which is known as an important prognostic factor, did not have a significant prognostic value, which could be due to the limited number of cases in our study.
在这项研究中，我们旨在探讨影响成人高级别神经胶质肿瘤患者生存的预后因素。该回顾性研究纳入了2010年至2017年期间连续79例转介至我诊所进行辅助放疗/放化疗的患者。采用单因素和多因素分析评估预后因素对总生存期(OS)和无病生存期(DFS)的影响。中位年龄56.63岁(范围24-84岁)，诊断时的中位Karnofsky Performance Status (KPS)为89%(范围50-100%)。大多数病例(n=69;87.1%)组织学诊断为世界卫生组织(WHO) IV级。中位随访12个月时，OS和DFS分别为12个月和8个月。单因素分析发现年龄、KPS、IDH1、p53、Ki-67状态在影响OS的预后因素中有统计学意义，多因素分析中只有KPS、p53、Ki-67有统计学意义。单因素分析发现年龄、KPS、IDH1和Ki-67是影响DFS的显著因素，多因素分析发现只有KPS和Ki-67是影响DFS的显著因素。KPS是OS和DFS最重要的预后因素。在评估术后组织病理学结果时，发现p53和Ki-67是OS的预后指标，而只有Ki-67是DFS的预后指标。然而，IDH1被认为是一个重要的预后因素，但没有显著的预后价值，这可能是由于我们研究的病例数量有限。
{"title":"Correlation of IDH1, p53 and Ki-67 immunoexpression levels with morphological, clinical prognostic parameters and preoperative/postoperative radiological findings and response to treatment in high-grade glial tumor case","authors":"Murtaza Parvizi, Ulkun Unsal, Olcay Nalbant, Derya Demir, Murat Akyol, Aydin Isisag","doi":"10.5455/medscience.2023.09.186","DOIUrl":"https://doi.org/10.5455/medscience.2023.09.186","url":null,"abstract":"In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy/radiochemotherapy between 2010 and 2017. The effect of proposed prognostic factors on overall survival (OS) and disease-free survival (DFS) was evaluated with univariate and multivariate analyses. Median age was 56.63 (range, 24-84) years and the median Karnofsky Performance Status (KPS) at diagnosis was 89% (range, 50-100%). Most the cases (n=69; 87.1%)were histologically diagnosed as World Health Organization (WHO) grade IV. At a median follow-up of 12 months, OS and DFS were 12 and 8 months, respectively. Although age, KPS, IDH1, p53 and Ki-67 status were found to be statistically significant among the prognostic factors affecting OS in univariate analyses, only KPS, p53 and Ki-67 were statistically significant in multivariate analysis.In contrast, age, KPS, IDH1, and Ki-67 were found to be significant factors for DFS in univariate analysis, while only KPS and Ki-67 were found to be significant factors for DFS in multivariate analysis. KPS was the most important prognostic factor for OS and DFS. In the evaluation of postoperative histopathological findings, p53 and Ki-67 were found to be prognostic for OS while only Ki-67 was prognostic for DFS. However, IDH1, which is known as an important prognostic factor, did not have a significant prognostic value, which could be due to the limited number of cases in our study.","PeriodicalId":18541,"journal":{"name":"Medicine Science | International Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135709808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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